#Phytochemicals Phytic Acid Inhibits Markers and Expressions Associated with Proliferation of #ColorectalCancer, Researchers Suggest

Kyle J. Norton

Colorectal cancer also known as bowel cancer, is a medical and chronic condition characterized by the abnormal proliferation of cells in the colon, rectum, or vermiform appendix due to the alternation of DNA with unidentified origin.

Colorectal cancer (CRC) is a relatively very common cancer in the Western world. The cancer is considered a slowly growing and progressing cancer in a predictable way.

The bowel is divided into 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food, and the 2nd part, the large bowel which consists the the colon and rectum, is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.


Why colorectal cancer is more susceptible to the West than other parts of the world. Some researchers suggested it may be a result of the Western diet. People who the diet with high saturated and trans fats, red meat, processed foods, and fewer fruits and vegetables, whole grain are associated with a substantially higher risk to colorectal cancer, compared to traditional diet.

Dr. Alan Moss, the lead author in the cancer program at The University of Melbourne, a diet that contains high levels of red meat is associated with the risk of CRC.

The risk of colorectal is increased proportionally to the increased intake of red meat. In other words, the redder consumed the higher the risk of CRC.

And, processed meats result from salting, smoking, fermenting, or curing the meat, and common examples include ham, bacon, and sausage are also in the list of elevated the risk of colorectal cancer.


In the comparison of the “Western” and “prudent” dietary patterns on the incidence of CRC, researchers showed that people who follow the Western diet have a 31% increased risk of the disease onset, compared to a 14% reduced risk of CRC in people who follow the prudent diet with high fruits and vegetables, fewer red meat and processed foods.

These results suggested, that regardless to present the colorectal cancer risk, the change of diet pattern today, your risk the cancer is continuously lower, compared to before the change.

Dr., Shafie NH, the lead scientist in the researchers at the cancer program team at the Universiti Putra Malaysia the examined whether phytic acid, a natural dietary ingredient and an essential component of nutritional diets affects colorectal cancer risk showed
* Phytic acid exerted a strongly inhibitory colorectal cancer activity by increasing the function of proteins (up-regulation of Bax)associated with program cell death and (down-regulation of Bcl-xl) anti-cancer cell proliferation.
* Furthermore, when exposed to IP6 (phytic acid), the phytochemical up-regulates of caspase-3 and -8 expressions and activation of both caspases may also contribute to the apoptotic cell death of human colorectal adenocarcinoma HT-29 cells.

Phytic acid, an organic compound found much in healthy food sources may have a potential effect in reducing the risk and treatment of colorectal cancer, some studies suggested.

Foods containing high levels of phytic acid including nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds,...

The results suggested, combined with t rice bran IP6 (phytic acid) induced apoptosis, by regulating the pro- and anti-apoptotic markers.

Moreover, in reaffirming the significant role of phytic acid in the inhibition of colorectal cancer, Dr. Saad N, the team leader, and colleagues launched an investigation of expression changes of β-catenin and cyclooxygenase-2 (COX-2) and cell proliferation in the adenoma-carcinoma sequence after treatment with rice bran PA by immunocytochemistry.

The experiment includes a total of 72 male Sprague-Dawley rats divided into 6 equal groups with 12 rats in each group.

Cancer induction by two intraperitoneal injections of azoxymethane (AOM) was given at 15 mg/kg body weight over a 2-week period. During the post-initiation phase, two different concentrations of PA, 0.2% (w/v) and 0.5% (w/v) were administered in the diet.

Before treatment with PA, rats-induced cancer showed that β-catenin, a marker of alternation of gene transcription, COX-2 expressions associated with cancer cell proliferation, and cell proliferation of Ki-67 associated with a significant contribution in colonic cancer progression.

And, a significant positive expression and correlation were found between COX-2 expression and proliferation and the total β-catenin also demonstrated a significant positive linear relationship with total COX-2.

After application phytic acid, researchers found that the expression changes of β-catenin and cyclooxygenase-2 (COX-2) and cell proliferation in the adenoma-carcinoma sequence were totally inhibited by rice bran PA.

Taken together, there is no doubt that phytic acid can be considered a functional supplement in the prevention of colorectal cancer and combined with primary therapy for the treatment of the disease without inducing any side effects.

However, further data collection large example size and multi-center studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of phytic acid anti-colorectal cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Pro-Apoptotic Effect of Rice Bran Inositol Hexaphosphate (IP6) on HT-29 Colorectal Cancer Cells by Shafie NH, Esa NM, Ithnin H, Saad N, Pandurangan AK. (PubMed)
(2) Suppression of β-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice branphytic acid (PA) by Saad N, Esa NM, Ithnin H.(PubMed)
(3) The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations by Alan Moss and Kumanan Nalankilli (Gastroenterology)

#Carotenoids Exert Preventive and Therapeutic Benefits Against Age-Related Eye Disease, According to Studies

Kyle J. Norton

Age-related eye disease is a class of medical conditions associated with vision impairment due to aging.
Most common types of age-related eye disease are
* Age-related macular degeneration (AMD) is a medical condition that causes irreversible blurring of the central vision in people over age 60.

The most common symptoms of AMM are slightly blurred central vision. Most cases of the early stage of AMD were diagnosed during routine eye health examinations.

Over time, age-related macular degeneration may affect the vision including the reading as the blurred area increases in size.

The risk factor associated with AMD is shadowy areas in your central vision or unusually fuzzy or distorted vision, particularly in seeing wavy or blurred, with some dark areas at the center.

* Cataract
A cataract occurring in one or both eyes is a condition characterized by the clouding of the lens in the eye that affects vision. Most cases of cataracts are found in older adults.

Believe it or not, by age 80, more than half of all Americans either have a cataract or have had cataract surgery.

The risk factors associated with cataracts are aging, a lifetime of exposure to ultraviolet radiation contained in sunlight, cigarette smoking, a poor diet, and alcohol consumption are some of the prevalent factors associated with cataract developing.


* Diabetic eye disease
Diabetic eye disease is a severe complication of diabetes, a leading cause of blindness as a result of damage to the tiny blood vessels inside the retina.

The risk factor associated with diabetic eye disease is an uncontrol diet and poor management of blood glucose.

* Glaucoma
Glaucoma is a medical condition of eye disease as a result of the damage of the nerves of the eyes over time. If left untreated, it can lead to permanent vision impairment and blindness.

The risk factor associated AMD are abnormal intraocular pressure (IOP), history of coronary artery bypass or vascular surgery, moderate-to-high myopia, medical conditions such as diabetes, heart diseases, high blood pressure, and hypothyroidism and long-term use of certain medication such as a corticosteroid.

Conventionally, there is no cure for the disease, treatment of age-related eye disease focuses on the improvement of quality of life, reducing symptoms, and slowing down the progression.

Carotenoids are a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomatoes, pumpkins, carrots, corn, and daffodils.

With an aim to find a natural ingredient for the prevention and treatment of eye diseases, researchers the antioxidant and anti-inflammatory activities of carotenoids and polyphenols.

The study included the search of medical literature on PubMed and Web of Science databases for original studies that investigate the benefits of different carotenoids and polyphenols in age-related ophthalmic diseases.


According to the differentiation of the selected studies, carotenoids (such as lutein, zeaxanthin, and neoxanthin) exerted significant preventive and therapeutic benefits against the aforementioned age-related eye diseases.

The efficacy of carotenoids in the protection of the age-related vision was attributed to the phytochemicals in
* Mitigating the production of reactive oxygen species, through its antioxidant activity.

* Inhibiting the tumor necrosis factor-α and vascular endothelial growth factor pathways involved in the stimulation of the formation of blood vessels in age-related ocular diseases.

*Protecting the cells in the eye against the overexpression of pro-inflammatory cytokines

* Suppressing the gene associated with cell apoptosis

Based on the findings, researchers wrote, "This review discusses the role and mechanisms of ...carotenoids and their possible synergistic effects on the prevention and treatment of age-related eye diseases that are induced or augmented by oxidative stress and inflammation".

Taken altogether, carotenoids may be considered a remedy for the prevention and treatment of age-related eye diseases, pending the confirmation of the larger sample size and multicenter human study.

Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Health Benefits of Polyphenols and Carotenoids in Age-Related Eye Diseases by Bungau S1, Abdel-Daim MM2,3, Tit DM1, Ghanem E4, Sato S3, Maruyama-Inoue M3, Yamane S3, Kadonosono K. (PubMed)
(2) The role of the carotenoids, lutein and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence by Maneli Mozaffarieh,1 Stefan Sacu,1 and Andreas Wedrich. (PMC)

#Kale Supplement Inhibits Hyperactive Parameters Agaisnt the Risk of #CardiovascularDisease, Researchers Suggest

Kyle J. Norton

Hypertension or high blood pressure, a condition associated with the cluster of metabolic syndrome is a medical condition associated with abnormally high blood pressure.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood and changes constantly depending on activity. However, persistent hypertension due to poor management over time can lead to cardiovascular disease.

According to the statistics provided by the American Heart Association., nearly half of all adults in the United States are living with high blood pressure, or 1 in 3 Americans are hypertensive.

Hypertension is the leading risk factor of heart disease and stroke in the US.

Cardiovascular diseases (CVD) including heart disease and stroke are a class of conditions associated with the dysfunction of the arteries and heart, affecting the heart functioning.

According to the statistics provided by the CDC, heart disease is the leading cause of death for both men and women. Men are associated with 1/2 of the deaths due to heart disease in 2015 were in men, comapred to women.

Believe it or not, more than 63,000 Americans die from heart disease each year or 1 in every 4 deaths are caused by heart disease.

The most common prevalent factors associated with hypertension onset are family history, aging, being male, being overweight or obese, ethnicity, physical inactivity, unhealthy diet, and medical conditions such as chronic kidney disease.

Excessive alcohol drinking is also one of the major causes besides obesity in elevating the syndrome onset.

Depending on blood pressure levels, most people with mild hypertension are asymptomatic. However, unmanaged high blood pressure can induce complications of heart attack or stroke, heart failure, weakened and narrowed blood vessels, metabolic syndrome, and trouble with memory or understanding,

Conventionally, blood pressure medications have been found to prevent many deaths from heart disease and stroke over the past 30 years, however, long-term intake of such medications has caused many side effects such as damaging the kidney.

Some researchers suggested by making changes to lifestyle, maintaining an ideal weight, and diet with low salt, you could do just fine without the drugs.

Dr. L. J. Beilin wrote, "Lifestyle factors are critical determinants of blood pressure levels operating against a background of genetic susceptibility. Excess body fat is a predominant cause of hypertension with additive effects of dietary salt, alcohol, and physical inactivity."

And "Controlled trials in hypertensives show blood pressure lowering effects of supplemental potassium, fiber, n-3 fatty acids, and diets rich in fruit and vegetables and low in saturated fats".

With an aim to find a natural food for the prevention and treatment of hypertension, researchers examined the effect of daily supplementation of kale juice in modulating blood pressure (BP).

The study included 84 subclinical hypertensive patients with systolic BP over 130 mmHg or diastolic BP over 85 mmHg who received 300 ml/day of kale juice for 6 weeks.

According to the blood samples obtained on 0-week and 6-week, kale supplements showed a significantly decreased systolic and diastolic blood pressure in all patients regardless of their GSTM1 or GSTT1 polymorphisms.

According to the joint study led by the Isfahan University of Medical Sciences, the GSTT1 and GSTM1 gene increases arterial pressure; hence, it can predict susceptibility to cardiovascular disease.

In other words, kale supplements inhibited the hyperactive parameters without being affected by the gene expression of GSTM1 or GSTT1 polymorphisms.

Furthermore, kale supplements exerted no effect on the plasma lipid profiles of patients with GSTM1-null and GSTM1-present genotypes.

More importantly, the supplement also increased plasma HDL-C and lowered LDL-C in the GSTT1-present type, while blood glucose was decreased only in the GSTT1-null genotype.

Based on the findings, researchers suggested, that kale processes a strong effect in lowering blood pressure through other mechanisms, regardless of GSTT1 and GSTM1 gene types.

Taken together, kale juice may be considered a supplement for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) The effect of glutathione S-transferase M1 and T1 polymorphisms on blood pressure, blood glucose, and lipid profiles following the supplementation of kale (Brassica oleracea acephala) juice in South Korean subclinical hypertensive patients by Han JH1, Lee HJ1, Kim TS2, Kang MH. (PubMed)
(2) Association of GSTT1 and GSTM1 polymorphisms with blood pressure: A Bayesian modeling of continuous data by Laleh Rafee, Mahsa Abedini,1 Shaghayegh Haghjooy Javanmard, Nizal Sarrafzadegan,2 and Marjan Mansourian. (PubMed)
(3) Lifestyle and hypertension by L. J. Beilin, I. B. Puddey, V. Burke. (the American Journal of Hypertension)

#Phytochemical Piperine Inhibits Angiogenesis of #Cancer Cells, Scientists Say

Kyle J. Norton

Piperine, a phytochemical alkaloid in the class of organosulfur compound may have a significant effect in blocking the energy that is necessary for cancer cells proliferation and survival, some scientists suggested.
Angiogenesis is the formation of new blood vessels in the body for healing and reproduction.

However, in invasive cancers, the formation of a new blood vessel from pre-existing vessels stimulated by cancer chemicals may be deadly to the host.

These new blood vessels provide the nutrients and fluids for cancer growth and metastasis.

Cancer is a class of diseases, characterized by cell growth irregularly that starts in the surface of the inner lining of tissue or organs. Patients at the beginning of cancer onset do not experience any symptoms.

At the later stage of the progression, the cancerous cell may travel a distance away from the primary site to infect other healthy tissues and organs. If cancer has grown large enough, it may affect other nearby healthy tissue and nerve cells, causing localized symptoms and persistently severe pain.

Angiogenesis occurs totally depends on a net balance of angiogenic factors and antiangiogenic factors, which are secreted by both tumor cells and host-infiltrating cells. If the tumor's angiogenic factors win, the new blood vessels are formed.

Some researchers suggested if we can produce a drug that cuts off the forming of the new blood vessel which supplies energy to cancer, we may cure cancer.

However, according to the epidemiological studies, antiangiogenic therapy in the inhibition of the growth of the tumor works best in combination with conventional cytotoxic chemotherapy.


Dr. Roberta WC Pang, the lead author in the investigation "Clinical Implications of Angiogenesis in Cancers" wrote, "Recently, a monoclonal antibody against vascular endothelial growth factor, which is one of the most potent angiogenic factors, has been approved for clinical use in colorectal cancer patients after a clinical trial confirmed that combining the antibody with standard chemotherapy regimen could prolong patient survival".


We can only hope that in a distant future, a single miracle drug can have an antiangiogenic potency to block off all cancers proliferation.

Piperine is a phytochemical alkaloid in the class of organosulfur compounds, found abundantly in white and black pepper, long pepper, etc.

A research team at the Dalhousie University in the investigation of piperine, a major alkaloid constituent of black pepper physiological actions in inhibition of cancer cell proliferation including the killing of cancer cells launched a study to examine the angiogenetic effect of piperine in tumor progression.

Injection of piperine inhibited the proliferation and G(1)/S transition of human umbilical vein endothelial cells (HUVECs) without causing cell death.


In vitro, piperine also inhibited HUVEC migration and tubule formation and collagen-induced angiogenic activity in rat aorta explants and breast cancer cell-induced angiogenesis in chick embryos.

Importantly, piperine inhibited phosphorylation of Ser 473 and Thr 308 residues of Akt (protein kinase B), which is a key regulator in the induction of cancer cells survival and angiogenetic proliferation.

The findings reconfirmed the function of piperine as an angiogenesis inhibitor for use in cancer treatment.

Additionally, the finding of the phytochemical which processes a strong effect in improving the function of curcumin, in the suppression of angiogenesis by inhibiting the curcumin's lack of water solubility, and relatively low bioavailability.

After multiple approaches were sought to overcome these limitations, researchers finally discovered natural curcumin analogs, namely piperine.

Piperine in the co-administration with curcumin enhanced the functions of curcumin in the suppression of angiogenesis without reducing the antitumor activity.


Taken together, piperine may be considered a functional supplement used for the prevention of cancers and an adjunction therapy by cutting the supply of energy of cancer that is life and death for cancer colonization, depending on the further study of large sample size and multi-center in human consumption.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Piperine, a dietary phytochemical, inhibits angiogenesis by Doucette CD, Hilchie AL, Liwski R, Hoskin DW.(PubMed)
(3) Clinical Implications of Angiogenesis in Cancers by Roberta WC Pang1 and Ronnie TP Poon. (PMC)

#Herbal #Bilberry Combined with Other Antioxidants or Conventional Medicines in theTreatment for Peyronie's Disease #PD, According to Studies

Kyle J. Norton

Peyronie's disease is a rare condition caused by plaque, that forms inside the penis, leading to a bent erect penis, depending on where the plaque is located.

Patients with Peyronie's disease has been found to affect sexual desire due to a physical condition associated with painful sexual intercourse and erectile dysfunction.

Researchers do not know the exact causes of Peyronie's disease. However, according to the epidemiological studies, researchers suggested that injury that causes bleeding inside the penis may induce the built-up of scars, particularly in men with the genetic preposition of certain genes.

Most cases of pain in Peyronie’s disease are mild and often do not require treatment, however, over counter medicine may be needed occasionally.

Believe or not, most mild cases of men with Peyronie's disease do not require treatment as the condition has been found to go away within a year. In severe cases, surgery may be necessary to remove the scar tissues in the penis that cause the condition.


Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as an herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

Researchers to find a natural compound for the treatment of Peyronie's disease investigated various antioxidants, including bilberry in PD treatment which significantly increase the likelihood of therapeutic success.

By comparing the effects of silymarin, ginkgo biloba, vitamin E, bilberry, topical diclofenac sodium, and pentoxifylline (PTX) in patients with PD, researchers found that by administration of a single oral antioxidant; two oral antioxidants; and three oral antioxidants; five oral antioxidants + local diclofenac; and five oral antioxidants + local diclofenac + PTX achieve better results when combining more than one agent.

According to the tested assays, the combination of more than a single compound reduced the symptoms in patients with PD, including the improvement and disappearance of penile pain; percentage of reduction in the volume of penile plaque; reduction in penile curvature; recovery of erectile function in patients with erectile dysfunction; increase in the International Index of Erectile Function score; and reduction of psychosexual impact.

Particularly, treatment of combined therapy including oral treatment with more than one antioxidant is greater when topical use of diclofenac gel and perilesional injection of PTX, compared to those of single conventional medicine.

In other words, combined natural or dietary antioxidants such as bilberry into the diet of patients with PD are more effective in inhibiting the symptoms compared to the use alone of any single ingredient therapy.


The final outcome of 6 months of treatment showed that combined antioxidant therapy is effective in treating PD.

Dr. Paulis G, the lead scientist, after taking other factors into account wrote in the final report, " Although several articles have already been published reporting the effectiveness of combined treatment in PD, this is the first study clearly proving how, as the number of substances used in treatment rises, a proportionally greater therapeutic effect is achieved."

Taken together, bilberry combined with other antioxidants or conventional medicines may be considered function remedies for the treatment of Peyronie's disease (PD), pending the validation of a larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Rationale of combination therapy with antioxidants in the medical management of Peyronie's disease: results of clinical application by Paulis G1,2, Paulis A3, Romano G4, Barletta D5, Fabiani A. (PubMed)

Indole-3-carbinol Cyclic Tetrameric Derivative (#CTet) Processes Anti #BreastCancer Activity, Researchers Reveal

Kyle J. Norton

Indole-3-carbinol may be the pharmaceutical target in the search for a chemo drug doe the treatment of breast cancer, some scientists suggested.

As a phytochemical in the class of Indoles, Indole-3-carbinol processes a unique function by the breaking down of the glucosinolate glucobrassicin found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.

Breast cancer is a medical and chronic condition caused by cell growth irregularly and uncontrollably in the breast tissue. At the early stage, in most cases, breast cancer starts in the cells of the inner lining tissue of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

At the advanced stage, breast cancer cells caused by the alternation of DNA can travel far away from the primary site to infect other healthy tissue and organs.

Most patients at the early may have a lump when touching with no symptoms.

Patients who inherited the genetic preposition of BRCA1 and 2 are associated with over 60% of the risk of breast cancer.

However, an unhealthy diet and lifestyle are some of the preventable risk factors that form a major cause of breast cancer onset.

Dr. Harvie M, the lead scientist on the breast cancer program team at the University Hospital of South Manchester NHS Foundation Trust, said, " The World Cancer Research Fund (WCRF) and American Cancer Society (ACS) cancer prevention guidelines recommend maintaining a healthy weight, undertaking at least 150 minutes of moderate-intensity exercise per week, limiting alcohol consumption, and eating a plant-based" and "Lifestyle factors appear to modify risk among high-risk women with a family history and those with typical risk of the general population".

In Postmenopause, weight control is the major factor throughout life that appears to prevent breast cancer after menopause.

Daily physical activity and reduced intake of alcohol throughout life are associated with reduced risk of developing pre- and postmenopausal breast cancer, however, smoking during adolescence or early adulthood increases later risk of breast cancer.

Interestingly, in the depth discussion of the diet pattern in the risk of breast cancer, researchers do not find a direct link to breast cancer risk.

These results suggested by actively following a healthy lifestyle and moderate exercise, the risk of breast cancer can be decreased substantially.

The team on the final report said, "Recent expert reports estimate that successful lifestyle changes could prevent 25% to 30% of cases of breast cancer".

According to the statistics, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.

Dr. the lead author in the research team of the cancer program in the investigation to examine the effect of indole-3-carbinol cyclic tetrameric derivative (CTet) in breast cancer cell proliferation by endoplasmic reticulum stress and autophagy-related cell death induction conducted an experiment to evaluate the synergistic activity of CTet in combination with cisplatin and doxorubicin in triple-negative breast cancer cell lines.

In MDA included -MB-231 and BT-20 triple-negative breast cancer cells, CTet in combination with both cisplatin and doxorubicin synergistically inhibits cell viability and induces autophagy.

The efficacy of the CTet and combination exerted a strong anti-cancer effect as seen in the MAP1LC3B gene that is responsible for a normal physiological process in the body in dealing with the destruction of cells.

Pre-treated with cisplatin and doxorubicin demonstrated a strong cytotoxic activity of CTet in cells in the tested cancer cell lines.

The findings reaffirmed the potential of CTet as a chemopreventive agent or chemotherapeutic in combination with standard approaches for triple-negative breast cancer.

Furthermore, indole-3-carbinol cyclic tetrameric derivative CTet induces autophagy and inhibits breast cancer cell proliferation, researchers at the University of Urbino Carlo Bo conducted an investigation to examine the antitumoral activity of a mixture of tri- and tetrameric cyclic I3C derivatives (CTr/CTet) both in vitro (MCF-7 and MDA-MB-231 breast cancer cell lines.

Observation of the application on the tested cancer cell line suggested CTr/CTet mixture inhibits breast cancer cell proliferation (IC50 = 1.3 and 1.6 μg/ml in MCF-7 and MDAMB- 231, respectively) inducing the G0/1 cell cycle phase accumulation.

The efficacy was attributed to the mixture in activating the overexpression of p21, p27 and GADD45A, which are the cell cycle regulators, nuclear translocation of FOXO3ain the induction of cell apoptosis and inhibition of Akt activity, and downregulation of estrogen receptor.in stimulating cancer cell proliferation.

Moreover, in Vivo, the tumor growth of xenotransplanted was also inhibited by reducing the function of Cyclin E and its low molecular weight which is important in the transition from G1 to the S phase of the cell cycle that determines the initiation of DNA duplication.


Taken together, Indole-3-carbinol processed apoptotic and antiproliferative activity can be considered a functional supplement for the prevention and combined with primary medicine for the treatment of breast cancer.

However, further data collection large example size, and multi-center studies performed with human consumption of the phytochemical during the course of the disease will be necessary to complete the picture of Indole-3-carbinol anti-breast cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The Indole-3-carbinol cyclic tetrameric derivative CTet synergizes with cisplatin and doxorubicin in triple-negative breast cancer cell lines by De Santi M1, Galluzzi L, Duranti A, Magnani M, Brandi G.(PubMed)
(2) Antitumoral activity of indole-3-carbinol cyclic tri- and tetrameric derivatives mixture in human breast cancer cells: in vitro and in vivo studies by Brandi G1, Fraternale A, Lucarini S, Paiardini M, De Santi M, Cervasi B, Paoletti MF, Galluzzi L, Duranti A, Magnani M.(PubMed).
(3) Can diet and lifestyle prevent breast cancer: what is the evidence? by Harvie M1, Howell A1, Evans DG. (PubMed)

#Phytochemical #Polysulfides Inhibit Pathways Associated with the Onset of #SkinCancer, Reserachers Suggest

Kyle J. Norton


Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belonging to the group of Organosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.
Skin cancer is a medical condition of uncontrolled growth of abnormal skin cells and is often detected at an early stage.

In skin cancer progression, diallyl trisulfide (DATS) is more potent than mono- and disulfides against skin cancer, through inhibited cell growth of human melanoma A375 cells and basal cell carcinoma (BCC) cells by increasing the levels of intracellular reactive oxygen species (ROS) and DNA damage and by inducing G2/M arrest, endoplasmic reticulum (ER) stress, and mitochondria-mediated apoptosis(1).

The study by the National Taiwan University, also showed that Diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS), extracted from crushed garlic, inhibited skin cancer cell growth through involvement in G(2)/M arrest and apoptosis via activation of the p53 pathway in response to the oxidative DNA damage(2).


The Chung Shan Medical University Hospital, study also insisted that DAS protects against ultraviolet B (UVB)-induced skin tumor formation through anti photocarcinogenesis effect accompanied by the down-regulation of cell-proliferative controls, involving thymine dimer, PCNA, apoptosis, transcription factors NF-κB, and of inflammatory responses involving COX-2, PGE2, and NO, and up-regulation of p53, p21/Cip1 to prevent DNA damage and facilitate DNA repair in hairless mice(3).


References
(1) Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression by Wang HC1, Pao J, Lin SY, Sheen LY. (PubMed)
(2) Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis By Wang HC1, Yang JH, Hsieh SC, Sheen LY. (PubMed)
(3) Diallyl sulfide protects against ultraviolet B-induced skin cancers in SKH-1 hairless mouse: analysis of early molecular events in carcinogenesis by Cherng JM1, Tsai KD, Perng DS, Wang JS, Wei CC, Lin JC.(PubMed)