Coffee and #Coffee #Caffeine Inhibit Gene and Protein Expression Associated with a Reduced Risk of #Obesity, Researchers Say

Kyle J. Norton


In comparison to herbal medicine, food therapy even takes longer to ease symptoms, depending on the stages of the treatment that directly address the cause of the disease.

Coffee, second to green tea is a popular and social beverage all over the world, particularly in the West, made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.

Obesity is a medical condition of excess body fat accumulated over time. According to the Body Mass Index(BMI), a BMI of over 30 is an indication of obesity.

Good news for coffee lovers, bioactive components found in coffee may have a potential effect in reduced risk and management of obesity, a renowned institute study opinionated.

According to the joint study led by the National Taiwan University, the efficacy of coffee in reduced risk and management of obesity over the last 10 years of research, may be attributed to
1. decrease lipid accumulation in cells via the regulation of the cell cycle in fat tissue
2. improved fat metabolic formation in both protein and transcription factor expression

According to animal studies.
In humans, it is the result of decreased body weight and visceral fat stored within the abdominal cavity.

Furthermore, the study also expressed the importance of coffee intake in influencing the gut microbiota in obese animals and humans.

Additionally, in the evaluation of possible lipid catabolism and body fat regulation effects of 3-caffeoylquinic acid in Green coffee bean extract (GCBE) in high-fat diet (HFD)-induced obese mice fed with only HFD or HFD with GCBE at 50, 100, and 200 mg/kg, respectively, researchers filed the following results
1. The treated group showed a significantly decreased body weight gain, and liver and white adipose tissue weights, but importantly intake of coffee also regulated adipose tissue lipolysis hormones in breaking down fat accumulation.

2. The efficacy of the treatment group in reduced obesity risk may also benefit the decreased mRNA expression levels of adipogenesis and adipocyte metabolism in both gene and protein expression.

3. Compared to other treated groups, GCBE-treated mice displayed a lower fat mass and relative body weight and decreased fat mass.

More importantly, in the review of papers from in vivo, ex vivo, and in vitro experimental studies in animals and human tissues as well as wide population-based epidemiological studies in the last 10 years, researchers at the joint study led by the South University School of Pharmacy said, " there is mounting evidence of the reduced risk of developing type 2 diabetes by regular coffee drinkers of 3-4 cups a day. The effects are likely due to the presence of chlorogenic acids and caffeine, the two constituents of coffee in higher concentration after the roasting process".

Taken together, there is no doubt that coffee and coffee caffeine have a significant and potential effect in reducing risk and management of obesity, through various active biochemicals in dose deepening manner.


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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee by Pan MH1, Tung YC2, Yang G3, Li S3, Ho CT4.(PubMed)
(2) Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice by Choi BK1, Park SB2, Lee DR1, Lee HJ2, Jin YY3, Yang SH4, Suh JW5.(PubMed)
(3) Coffee consumption, obesity, and type 2 diabetes: a mini-review by Santos RM1, Lima DR2.(PubMed)

#Herbal #Angelica Inhibits #IntrinsicPathway Associated with #Apoptosis of Neuroblastoma Cells, Reseachers Find

Kyle J. Norton

The brain formed part of the central nervous system is the most complex organ made up of more than billions of nerve cells or neurons.

The functions of the brain are associated with the communication of trillions of connections called synapses and many specialized regions.
A neuron or nerve cell made of a cell body (also called soma), dendrites, and an axon, is a cell in the nervous system that carries electrical impulses.

Neurons are core components of the brain, spinal cord, and peripheral nerves that play an essential role in processing and transmitting information.
Neuroblastoma is cancer developed by the immature nerve cells found in several areas of the body, mostly in and around the adrenal glands.

Cancer most commonly affects children age 5 or younger compared to less often in older children.

According to the statistics provided by the Cancer Net, approximately 800 children are diagnosed with neuroblastoma in the United States.

And 90% of children affected by neuroblastoma are younger than 5.

Sadly, the five-year survival rate of cancer is less than 50%.

Most common symptoms totally depend on the area that has been affected
* Neuroblastoma in the abdomen can induce symptoms of pains, a mass under the skin that isn't tender when touched, and changes in bowel habits, such as diarrhea or constipation.

* Neuroblastoma in the chest may cause symptoms including wheezing, chest pain, and changes to the eyes, including drooping eyelids and unequal pupil size

Some patients with neuroblastoma may also experience symptoms of back pain, fever, unexplained weight loss, and bone pain.


On finding a natural ingredient for the prevention and treatment of brain cancer, scientists examined the effects of Angelica polymorpha Maxim root extract (APRE) cytotoxicity on neuroblastoma cells (NB).

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the final results of the experiment,
* APRE reduced cell viability in NB to a greater extent than in fibroblast cells.
* APRE could inhibit proteins and down-regulated pathways associated with cancer cell proliferation and survival.

* Furthermore, APRE promoted pro-apoptotic protein and inhibited the expression of proteins associated with anti-apoptosis.
* Moreover, APRE depolarized the mitochondria membrane potential and activation of caspase-3 associated with cell death in the SH-SY5Y cells.

Additional differentiation, researchers said, "APRE, the intrinsic pathway was solely responsible for inducing apoptosis as we also showed that the non-caspase autophagy pathway or ER stress-ROS mediated pathways were not involved".


Taken together, herbal angelica may be considered a remedy for the treatment of neuroblastoma, pending the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica polymorpha Maxim Induces Apoptosis of Human SH-SY5Y Neuroblastoma Cells by Regulating an Intrinsic Caspase Pathway by Rahman MA1, Bishayee K1, Huh SO. (PubMed)

Chaste Tree Berry 's #Extract Inhibits Parameters Associated with Liver Damage and Injury, Scientists Suggest

Kyle J. Norton

Chaste tree berry is found to associate with reduced risk of liver damage and diseases through various mechanisms, the recent study suggested
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.

In acetaminophen-induced hepatotoxicity in mice study, oral administration of chaste tree berry increased significantly the expression of levels of antioxidants in inhibition of free radicals domino' effect and levels of ferric ion in induced hepatotoxicity caused by acetaminophen.


According to Al-Hikmah University, the Hepatoprotective effects of chaste tree berries may also mediate the alternative effects of acetaminophen in serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, albumin, and total bilirubin levels which can also contribute to hepatoxicity.

Dr. Ajiboye TO said, " Vitex doniana fruits possess antioxidant properties and halted acetaminophen-mediated oxidative rout on cellular proteins, lipids and DNA, made possible by β-sitosterol, platycodin D, apigenin, saikosaponin, chrysin and ellagitanin, (the antioxidants) in the extract".

Furthermore, ethanol extract Vitex glabrata (EEVG) on carbon tetrachloride-induced liver damage in rats, .displayed also antioxidant activity in inhibited superoxide dismutase, GSH, lipid peroxidation (LPO), catalase, and peroxidase levels in liver homogenate.

Pre-treatment of the extract illustrated a strong inhibited effect against levels of LPO in CCl(4)-intoxicated livers and reduced the elevated serum levels of chemical compounds which can cause liver damage

In fact, the extract displays an enormous hepaprotective effect similar to those of silymarin through enhancing the antioxidant mechanisms of its components, predominantly artemetin.

According to the Vinayaka Mission’s College of Pharmacy study, in the CCl4-induced hepatic injury in albino rats, vitex extracts not only comparable to the standard drug, silymarin (100 mg/kg, p.o.), but also altered serum biomarker enzyme levels which were damaged through injection of CCI4, to near normal in treated rats.

Taking together, there is no doubt that Chaste tree berries may process a protective effect in reducing the risk of harmful chemicals and drug-induced liver damage, but the injection of a large amount should be taken with care.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Standardized extract of Vitex doniana Sweet stalls protein oxidation, lipid peroxidation, and DNA fragmention in acetaminophen-induced hepatotoxicity by Ajiboye TO1.(PubMed)
(2) Antioxidant and hepatoprotective effects of ethanol extract of Vitex glabrata on carbon tetrachloride-induced liver damage in rats by Sridevi VK1, Chouhan HS, Singh NK, Singh SK.(PubMed)
(3) Effect of ethanol extract of flowers of Vitex trifolia Linn. on CCL4 induced hepatic injury in rats by Anandan R1, Jayakar B, Karar B, Babuji S, Manavalan R, Kumar RS.(PubMed)

#EthanolExtract (EE) #Dandelion Porcess a Strong Gastric Emptying and Smooth Muscle Motility Activity, Researchers Find

Kyle J. Norton

The digestive system including the gastrointestinal (GI) tract, the liver, pancreas, and gallbladder processes the function to digest foods and transfer the nutrients and fluids to the body's needs.
There is no single cause of the gastrointestinal disorder. Researchers suggested that the cause of the disorder can be attributed directly to the digestive system, or other systemic problems that facilitate the onset of disease.

However, according to the epidemiological studies, bacterial infection, viral infection, inflammation, muscle dysfunction, gallstones, stress, and intake of certain anti-inflammatory drugs are associated with the onset of the acute and chronic digestive disorders.

Dietary factors also play an important in the reduction and promotion of digestive dysfunction. People who are overeating, eating too much fatty food, not consuming enough fiber, and consuming too much alcohol and smoking are at a higher risk of digestive diseases, including ulcers and gastric acid reflux.

Gastric emptying is a test that measures the time that takes for food to empty from the stomach and enter the small intestine. The test is used to find out why your child is vomiting, having stomach pain, or not gaining weight.

Gastrointestinal motility is the contraction of the smooth muscles of the gastrointestinal tract.

The gastroprotective effect is a process involved enhancing the function of the digestive system against the harmful organisms in induced chronic digestive disorder.

People with digestive problems may experience certain stomach discomfort, including bloating. constipation. diarrhea. heartburn, nausea and vomiting,......., and belly pain.

Untreated digestive problems over the long term can induce serious ailments of chronic illnesses, as the digestive system no longer performs its functions in provided nutrients and fluids to the needs of the body's cells and tissue.

The results of malnutriments over a long period of time can lead to weakened immune defense and reduced levels of antioxidants produced by tissues of the body in fighting against pathogens,

Dandelion is a herbaceous perennial plant, genus Taraxacum, belonging to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

In finding a natural ingredient for the improvement of digestive functioning, scientists examined the effects of Taraxacum officinale (TO) is a traditional herbal medicine on gastric emptying (GE) and smooth muscle motility.

According to the administration of ethyl acetate fraction (EA), n-butanol fraction (BF), and aqueous fraction (AF) prepared in succession from 70% ethanol extract (EE) of TO in phenol red meal adopt mice,
* The percentage of GE was 48.8 ± 6.1% (vehicle control), 75.3 ± 6.5% (cisapride positive control), 68.0±6.7% (EE), 53.3±6.0% (EA), 54.1±6.3% (AF), and 86.0±6.5% (BF).

* Furthermore, BF was most effective in accelerating GE, compared to others.

* Moreover, the stimulatory effect of BF on GE was also supported by the observation that BF increased spontaneous contraction of the gastric fundus and antrum and decreased the spontaneous motility of pyloric sphincter in vitro.

Based on the findings, researchers said, "BF seems to be a promising prokinetic agent. BF-induced increase in the contraction of fundus and antrum contributes to an increase in the intra-gastric pressure. BF-induced decrease in the motility of pyloric sphincter contributes to a decrease in the resistance of food from the stomach to the small intestine"

And "The acceleration of GE by BF is likely to be exerted through cholinergic stimulation".

Taken together, Dandelion that processed the aforementioned chemical compounds may be considered a gastric emptying and smooth muscle motility remedy, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The effect of Taraxacum officinale on gastric emptying and smooth muscle motility in Rodents by Jin YR1, Jin J, Piao XX, Jin NG. (PubMed)

#Cranberry #Anthocyanidins in the Promotion of Gut Microbiota in the Flavor of the Good Bacteria, According to Studies

Kyle J. Norton

The digestive system including the gastrointestinal tract, the liver, pancreas, and gallbladder plays a critical role in maintaining the body's normal function by providing nutrients and fluids to the body and removing waste through the secretary system.

Digestion is a process of the digestive system by breaking down food for nutrients through mechanical and enzymatic action.

Gut Microbiota is a community of microorganisms living in the gastrointestinal tract.

Under normal conditions, gut microbiota plays a critical role in overall health, including improving the absorption of dietary nutrients in the digestive system, and protecting the body against xenobiotics and drug toxicity by facilitating the excretion.

Futhermore, the gut microbiota is also involved in the maintenance of the structural integrity of the gut mucosal barrier, gut microbiota enhances the epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of the intestine in nutrient adsorption.

In immunomodulation, gut microbiota interacts with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

However, an imbalance in the ratio of gut microbiota may have a negative on human health and diseases.

Dr. Yu-Jie Zhang wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function".

, "However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of digestive health, researchers examined the effect of Vaccinium berry fruit in modulating gut microbiota function.

According to the tested differentiation, cranberry anthocyanidins only interfered with the colonization of the gut by Escherichia coli in vitro but also attenuated gut barrier dysfunction caused by dietary insults in vivo.

The efficacy of cranberry anthocyanidins in the promotion of gut microbiota in the flavor of the good bacterias was attributed by the synergic activity between these proanthocyanidins, other cranberry components such as isoprenoids and xyloglucans.

Furthermore, cranberry constituents and their bioactive catabolites also have a strong effect on bacterial adhesion, coaggregation, and biofilm formation that may contribute clinical benefits on gastrointestinal and urinary tract infections,

Additionally, cranberry constituents and their bioactive catabolites also processed strong anti-inflammatory actions by mediating the gut microbiome.

Taken altogether, cranberry may be considered a remedy for the improvement of digestive health, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015 by Blumberg JB1, Basu A2, Krueger CG3, Lila MeseaNeto CC5, Novotny JA6, Reed JD3, Rodriguez-Mateos A7, Toner CD. (PubMed)
(2) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang, Sha Li and Ren-You Gan. (Research Gate)

#Herbal #Bilberry Decreases Lipoprotein Profiles in Clinical Trials, Researchers Find

Kyle J. Norton

The lipoprotein profiles or lipoprotein parameters are a general term comprised of the traditional lipoprotein profile including total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride.
Total cholesterol is the total amount of cholesterol in your blood, including the low-density lipoprotein (LDL, or “bad”) cholesterol and high-density lipoprotein (HDL, or “good”) cholesterol.


The healthy ratio of blood cholesterol is less than 4 of the low-density lipoprotein to 1 of the high-density lipoprotein.


Where low-density lipoprotein is produced by the liver or from food sources needed for the cells to build strong membranes, and produce steroid hormones, vitamin D, and bile to aid the digestive system in absorbing nutrients and fluids.

And high-density lipoprotein produced by the liver or from external sources is needed to return the low-density lipoprotein back to the liver.

Triglycerides, an important measure of heart health is the fat in the blood caused by the over-consumption of foods containing fat, carbohydrates, and simple sugars.

Factors that affect your lipoprotein profiles can be unpreventable including age, gender, race, and genetic preposition and preventable such as diet, weight, physical activity, and smoking.


Some researchers suggested that people who are obese are at a substantially higher risk of poor lipoprotein profiles.


Dr. Pandolfi C, the lead scientist wrote, "Lipid pattern has resulted in overlapping both in the two studied populations and in the two subgroups of pre-and postmenopausal women, while greater concentrations of Lp(a), (p < 0.001) and t-PA (p < 0.05) have been found in obese populations vs controls".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

In the urgency of finding natural sources of plant-based compound for the prevention of cardiovascular disease (CVD), researchers investigated regular consumption of bilberries in CVD risk reduction.

Women (n=25) and men (n=11) selected for the study received 150 g of frozen stored bilberries 3 times a week for 6 weeks. All parameters associated with the risk of CVD were measured by standard assays.

In both sexes, the consumption of bilberries led to a decrease in the parameters of lipoprotein profiles, including total cholesterol, LDL-C, TG, and a positive increase in HDL-C.

However, in men, additionally, favorable changes were observed in total cholesterol (P=.004), reduced oxidative stress, and HDL-C, but an increase in LDL-C compared to the women group.


In other words, the regular intake of bilberries can be important to reduce CVD risk, by promoting a decrease of LDL-C/TG and an increase of HDL-C.

Furthermore, in order to reveal more information about bilberry against CVD risk, researchers compared consumed dried sea buckthorn berries (SBs), sea buckthorn oil (SBo), sea buckthorn phenolics ethanol extract mixed with maltodextrin (SBe+MD, 1:1), or frozen bilberries on metabolic profiles.


In a total of 80 women selected to complete this randomized crossover study for 30 d, all interventions induced a significant effect on the overall metabolic profiles, particularly in lipid parameters observed both in participants who had a metabolic profile that reflected higher cardiometabolic risk at baseline (group B) and in participants who had a lower-risk profile (group A).

However, the bilberries treatment group caused beneficial changes in serum lipids and lipoproteins in group B, whereas the opposite was true in group A.

The finding clearly suggested bilberries modulated the parameters of lipids and lipoproteins depending on the risk of CVD.

Dr. Larmo PS, after taking into account co and confounders wrote, "Berry intake has overall metabolic effects, which depend on the cardiometabolic risk profile at baseline (including bilberry)".

Taken together, bilberry may be considered a functional remedy for the promotion of lipid-protein profiles in reducing the risk of CVD, pending the validation of a larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(2) Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial by Larmo PS1, Kangas AJ, Soininen P, Lehtonen HM, Suomela JP, Yang B, Viikari J, Ala-Korpela M, Kallio HP. (PubMed)
(3) [Lipoprotein(a), parameters of lipid metabolism and hemostasis in obese patients].[Article in Italian] by Pandolfi C1, Pellegrini L, Dedè A, Lo Vecchio M, Mercantini F. (PubMed)

#Sodium Ferulate and #Polysaccharides Fraction Found in Herbal #Angelica Induce a Strong and Positive Effect on #Osteoarthritis

Kyle J. Norton


Osteoarthritis (OA) is a form of arthritis, found in the general term of musculoskeletal disorders (MSDs) characterized by wear and tear on joints.

The chronic and medical condition affects over 25 million people in the United States alone.

The characteristics of osteoarthritis are aching pain, stiffness, or difficulty in moving the joint or joints. Therefore one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), compared to other types of arthritis.

Furthermore, the pain usually gets worse in a change of weather, at night, and in advanced diseases, and the pain can occur even at rest.

In contrast to the general belief, osteoarthritis only damages the joints of the hands and knees, but also causes inflammation of the joints in your hips and spine.

The condition is a slow development disease, often starting in the 40s and 50s, and affects almost all people to some degree by age 80.

The common risk factors of osteoarthritis are aging, gender, improper healing of injured joints at a young age, obesity, and bone deformity. However, people who have a job with tasks that place repetitive stress on a particular joint are associated with the onset of osteoarthritis in most industrial countries.


According to the statistics from the NIH, osteoarthritis (OA) is the most common joint disorder in the US. Among adults, 60 years of age or older the prevalence of symptomatic knee and sadly OA affects approximately 10% of men and 13% of women.

Epidemiological strongly suggest that obese and overweight have a strong impact on the weight-bearing joints, the genetic preposition of a patient can make such a patient more susceptible to the disease compared to others who do not. People with a joint injury that did heal properly in a younger age and people with occupations that require standing for long periods of time, repetitive bending, heavy lifting, or other movements, and the increase in age are associated with the increased risk of the onset of the disease.

In finding a natural ingredient for the prevention and treatment of aging-related diseases, scientists examined the angelica phytochemical, sodium ferulate, and a polysaccharide fraction on osteoarthritis animal models or in human chondrocytes stimulated by the proinflammatory cytokine, Interleukine-1β.


Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.


According to the results of the experiment,* Sodium ferulate found in angelica exhibited marked anti-inflammatory and anti-apoptotic properties by inhibiting the TNF/TNFR signal transduction pathway associated with inflammation and autoimmunity.

* On another hand, the polysaccharide fraction which contains a mixture of various carbohydrates was found to promote proteoglycan biosynthesis in the cartilage matrix by stimulating the activity of the UDP-glycosyltransferases that synthesize the chondroitin sulfate chains of aggrecans.


In other words, both chemical compounds demonstrated strong protective effects against osteoarthritis through different mechanisms.

based on the findings, researchers said, "the combined action of sodium ferulate and polysaccharides fraction would prevent cartilage destruction in osteoarthritis and favor cartilage repair".


Taken together, herbal angelica may be considered an antioxidant remedy for the treatment of osteoarthritis, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica sinensis and osteoarthritis: a natural therapeutic link? by Magdalou J1, Chen LB2, Wang H3, Qin J2, Wen Y2, Li XJ3, Shang L3, Li J. (PubMed)