#Brassica Oleracea Vegetable's #Isothiocyanates (ITCs) Isolated from Purple Cabbage Extract Inhibit the Risk of #ColorectalCancer, Researchers Say

Kyle J. Norton

The colon-rectum formed as a part of the digestive system is involved in the absorption of water from the small bowel contents and breaks down certain materials in the feces into substances, some of them to be reabsorbed and reused by the body.

Cancer is a class of diseases characterized by irregular cell growth on the body tissue, due to the alternation of cell DNA.

Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells' DNA.

According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.

The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. Colorectal Cancer also causes the death of over 50, 000 people, representing 8.3% of total cancer death.

Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, the increase in age, family and personal history, and genetic preposition are some of the prevalent risks of the disease.

Overall, the lifetime risk of colorectal cancer developing is 1 in 22 (4.49%) in men and 1 in 24 (4.15%) in women.

In finding a potential whole for the treatment of cancer, researchers examined the effect of principal bioactive compounds, isothiocyanates (ITCs) on a colorectal cancer cell line (HT-29).


According to the chemicals analysis, purple cabbage extract showed the highest ITC concentration per gram, fresh weight, followed by black cabbage and Romanesco cauliflower.

ITC at the concentrations of 7.08 microg/mL decreased cancer cell viability by inducing the caspase-3 associated with cell death and DNA fragmentation at 48h.

Brussels sprouts showed the strongest effects on cell viability and caspase-3 activity.

Furthermore, all varieties of Brassica Oleracea with rich sources of ITCs potently inhibit the growth of colon cancer cells by inducing apoptosis.

All the extracts showed anticancer activity at ITC concentrations of between 3.54 to 7.08 mg/mL,

Based on the findings, researchers said, " ITC concentration and the chemopreventive responses of plant extracts vary among the varieties of Brassica Oleracea studied and among their cultivars".

Taken altogether, Brassica Oleracea vegetables may be considered functional foods for the prevention and treatment of colorectal cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Induction of apoptosis in HT-29 cells by extracts from isothiocyanates-rich varieties of Brassica oleracea by Mas S1, Crescenti A, Gassó P, Deulofeu R, Molina R, Ballesta A, Kensler TW, Lafuente A. (PubMed)

#GreenTea Improves #InsulinSensitivity and Glycaemic Control in #Diabetes, According to Studies

Kyle J. Norton

Green with a ton of phytochemicals has been found to process various health benefits reported by large numbers of research and studies. However, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" according to traditional Chinese medicine's Yin-Yang theory. It is recommended to add a slice of ginger to your drink for the purpose of neutralization.

Recently study by a renowned institute postulated that regular green tea intake may be associated with reduced risk of developed hyperglycemia in a healthy individual and prevented the early onset of diabetes in people with hyperglycemia.


According to the Third Military Medical University, regular consumption of green tea or green tea extract improved insulin sensitivity and glycaemic control in populations with diabetics.

In the review of the literature found in a database of PUBMED, The Cochrane Library, EMBASE, ISI Web of Knowledge, Chinese Biomedical Literature Database and Chinese Scientific Journals Fulltext of 17 trials comprising a total of 1133 subjects suggested that green tea consumption significantly reduced the fasting glucose and hemoglobin A1c (Hb A1c) concentrations by -0.09 mmol/L and -0.30%, respectively.

In the trials with high Jadad score studies, green tea significantly reduced fasting insulin concentrations by -1.16 μIU/mL compared to the nongreen tea drinker group.

Other, in the mice study to evaluate green tea drink (T2 and T3) prepared by adding catechins and epigallocatechin gallate, major constituents isolated from green tea (EGCG) @ 550 mg/500 mL against non-drinker group acted as control (T1), mice fed with T2 and T3 expressed a significant reduced cholesterol and LDL levels and serum glucose and insulin levels with no difference in all functional drink groups but control.

Dr. Ahmad RS, the lead author said, "In contrast to lipid profile, an experimental drink containing EGCG reduced the trait better than catechins-based functional drink".

Furthermore, the compared diabetic effects of 3 selected tea water extracts (TWE) and tea pomace extracts (TPE) and by on rat intestinal α-glucosidase activity in vitro as well as hypoglycemic effects in vivo, insisted that in male Sprague-Dawley (SD) rats fed with tea extracts improved levels of blood glucose level at 30 min after oral intake (0.5 g/kg body wt) in compared to the control in sucrose-loaded SD rat, probably through activation of antioxidants properties in free radical scavenging.


Indeed, tea pomace extract in the study exerted a significant inhibition of intestinal α-glucosidase, in delayed glucose absorption resulting in suppressing postprandial hyperglycemia.

No doubtfully, green tea processed bioactive may be used as a potential nutraceutical product to prevent the risk of hyperglycemia in healthy people and early onset of in people with prediabetes.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized controlled trials by Liu K1, Zhou R, Wang B, Chen K, Shi LY, Zhu JD, Mi MT.(PubMed)
(2) Preventive role of green tea catechins from obesity and related disorders especially hypercholesterolemia and hyperglycemia by Ahmad RS1, Butt MS2, Sultan MT3, Mushtaq Z4, Ahmad S5, Dewanjee S6, De Feo V7, Zia-Ul-Haq M8.(PubMed)
(3) Selected tea and tea pomace extracts inhibit intestinal α-glucosidase activity in vitro and postprandial hyperglycemia in vivo by Oh J1, Jo SH2, Kim JS3, Ha KS4, Lee JY5, Choi HY6, Yu SY7, Kwon YI8, Kim YC9(PubMed)

#Phytochemical #Tartaricacid Shows a Strong Anti-bacterial Activity, Scientists Say

Kyle J. Norton

Phytochemicals may be the next potential source of new medications for the treatment of diseases with little or no side effects.

Tartaric acid, a phytochemical of the organic acid may be considered an alternative antibiotic remedy to replace conventional medicine for the treatment of infectious diseases caused by harmful bacteria, some studies suggested.

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer color.

Out of millions of bacteria present in this world, only a hundred of them cause infectious diseases. And, most bacteria that cause large-scale disease in human history may be closed to extinction.

In contrast to general belief, most bacteria live as independent cells, they share the basic characteristics of all living things, they breathe, metabolize, produce waste, and maintain a membrane potential.

However, bacteria do not process a nucleus in which their DNA is separated from the rest of the cell.

In the differentiation of bacteria, one must know that not all bacteria are bad. Some bacteria found in the digestive tract have been found to aid digestion and prevent the imbalance of bad and good bacteria. In other words, most bacteria are harmless.

Bacteria can enter our body to cause infection through an open wound, drinking bacterially contaminated water, close contact with infectious patients, or breathing in the exhaled droplets of an infected person.

In order to protect the body against bacterial invasion, the immune white blood cells after sensing the presence of harmful pathogens stimulate the production of pro-inflammatory cytokines to the site of infection with an aim to destroy the bacteria before causing damage to the body.

However, overproduction of proinflammatory cytokines in some cases can also cause the death of healthy cells, leading to improper healing with the formation of scars.


Tartaric acid is a phytochemical of the organic acid found abundantly in nuts, apricots, apples, sunflower, avocado, grapes, etc.

In the finding natural antibiotics without inducing side effects as of those in conventional medicine, researchers at the Mississippi State University conducted an experiment to examine the anti-bacterial effects of the water-soluble extracts prepared from purple (cultivar Ison) and bronze (cultivar Carlos) muscadine seeds with or without heating.


Application of the Ison extracts displayed a strong antimicrobial activity against a cocktail of three strains of Escherichia coli O157: H7.

Chemical analysis suggested the extract had a higher acidity (pH 3.39 to 3.43) compared to normal extract.

The major chemical compounds associated with the antibacterial activity include total phenolics (2.21 to 3.49 mg/ml), tartaric acid (5.6 to 10.7 mg/ml), tannic acid (5.7 to 8.1 mg/ml), and gallic acid (0.33 to 0.59 mg/ml), are also higher than those of the Carlos extracts.

Furthermore, heat treatment on both extracts increased antimicrobial activity, possibly because of increased acidity of the tartaric acid, total phenolics, and individual phenolics.

Heating of Ison extracts increased ellagic acid up to 83%. higher than the minimum of 10.7 mg/ml tartaric acid used alone exerted a strong effect against E. coli O157:H7.

However, up to 10.7 mg/ml tartaric acid alone was not as effective against E. coli O157:H7 as were water-soluble seed extracts.

The ingredients that are responsible for the antibacterial efficacy of the purple (cultivar Ison) and bronze (cultivar Carlos) muscadine seeds are tannic and gallic acids, which process the property of inactivation of pathogens.

Dr. Kim TJ, the lead author, on the final phase of the study, wrote, "Water-soluble muscadine seed extracts may be useful for incorporation into juice and other beverage products as natural preservatives"

Taken together, tartaric acid exerted a significant effect in the inhibition of bacterium may be considered a functional phytochemical for the prevention and an adjunct therapy combined with the primary medicine for the treatment of bacterial infection.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To ProfessionalsPrediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Reference
(1) Antimicrobial effect of water-soluble muscadine seed extracts on Escherichia coli O157:H7.

#Turmeric's #Curcumin Inhibit the Risk of Thyroid Cancer by Increasing the Expression of Tumor Suppressor and Decreasing Overexpression of Vimentin, Scientists Suggest

Kyle J. Norton

Cancer is a group of medical and chronic diseases characterized by cell growth disorderly and uncontrollably in the tissue of specific organs in the body.

Over time, the alternative cells-induced tumor may become progressively worse and damage other healthy tissues, depending on the grade of the tumor.

At the later stage, the most invasive tumor can induce secondary metastasis by spreading to other organs in the body via lymph or blood.

According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes, according to the data from 2013–2015.

In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer, and 1,790 died of the disease.

The thyroid, one of the largest endocrine glands found in the neck, below the Adam's Apple plays an essential role in regulating the use of energy, making proteins, and producing hormones.

Thyroid cancer, the medical condition caused by alternation of the cells in the thyroid gland found 3 times more common in women compared to men, can be classified into 4 most common types
* Papillary thyroid cancer
Papillary thyroid cancer is the most common type of thyroid cancer, accounting for over 80 percent of all cases. It tends to develop in the women's age group between 30-40 years with the tendency to grow slowly.
Papillary thyroid cancer can be treated successfully if diagnosed early.


* Follicular thyroid cancer
Follicular thyroid cancer, the second most common thyroid cancer, accounts for over 15 % of all cases. It is a low-growing cancer with peak onset from ages 40 through 60.
Follicular thyroid cancer can be treated successfully if diagnosed early.

* Medullary thyroid cancer
Medullary thyroid cancer, the third most common thyroid cancer that makes up only 3 percent of all cases, arises from thyroid hormone-producing cells with abnormally high levels of calcitonin. Medullary thyroid cancer tends to grow slowly but it can spread to distant parts of the body, if not treated early.

* Anaplastic thyroid cancer
Anaplastic thyroid cancer is a rare case of thyroid cancer, accounting for less than 2 percent of all cases. It tends to grow and spread very quickly.
Anaplastic thyroid cancer is deadly, with only a 10% survival rate, 3 years after being diagnosed.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In finding a potential ingredient for the treatment of cancer, researchers examined the effect of curcumin on the invasion and metastasis of thyroid cancers.


According to the tested differentiation, curcumin inhibited the multiple metastasis steps of the K1 papillary thyroid cancer cell line.

In a dose-dependent manner, curcumin also suppressed K1 cell viability, attachment, spreading, migration, and invasion abilities.

Furthermore, curcumin could also inhibit the expression and activity of an enzyme associated with cancer cell proliferation.

Based on the findings, researchers said, "Curcumin might be an effective humouristic agent for the treatment of aggressive papillary thyroid carcinomas".

Moreover, in human papillary thyroid carcinoma BCPAP cells, curcumin exerted an anti-thyroid cancer effect by increasing the expression of the tumor suppressor E-cadherin and decreasing the overexpression of vimentin found in various epithelial cancers.

Additionally, curcumin also blocked the activated transforming growth factor -β1 associated with the expression and activity of an enzyme associated with cancer cell proliferation.

Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of thyroid cancer, pending the confirmation of the larger sample size and multicenter human study.


Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin inhibits metastasis in human papillary thyroid carcinoma BCPAP cells via down-regulation of the TGF-β/Smad2/3 signaling pathway by Zhang L1, Cheng X2, Gao Y2, Zhang C3, Bao J2, Guan H4, Yu H2, Lu R5, Xu Q6, Sun Y. (PubMed)
(2) Curcumin inhibits invasion and metastasis in K1 papillary thyroid cancer cells by Zhang CY1, Zhang L, Yu HX, Bao JD, Sun Z, Lu RR. (PubMed)
(3) Thyroid Cancer by Kyle J. Norton

#Sulforaphane (SFN) Isolated from Collard Greens Inhibit Pro-Inflammatory Cytokines Associated with Neuropathic Pain, Researchers Reveal

Kyle J. Norton

Neurological disorders are a class of diseases of the nervous system characterized by structural damage, and biochemical or electrical abnormalities in the brain, spinal cord, or nerves.

Neurodegenerative disease is a type of neurological disorder associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Neuropathic pain is a type of pain that affects the somatosensory nervous system due to damage or disease. Abnormal sensations called dysesthesia or pain from normally non-painful stimuli (allodynia) are some of the most common forms of neuropathic pain found in patients.

There are no obvious causes of neuropathic pain. However, medical conditions such as alcoholism, amputation, diabetes, nerve problems, HIV infection or AIDS, multiple myeloma, multiple sclerosis and shingles, and chemotherapy are some prevalent factors of neuropathic pain.

According to the joint study conducted by the Health Outcomes Practice, there are no published data on the broad prevalence of neuropathic pain (NeP) in the US. However, the 15,751 respondents reported pain (63.7%), of 2,548 data suggested that 10% of Americans may suffer from neuropathic pain (NeP). The rate of NeP in Blacks and Hispanics ethnicity was consistently higher compared to White


Most common treatments of NeP are the use of nonsteroidal anti-inflammatory drugs (44.2%), followed by weak opioids (31.7%), antiepileptics (10.9%), and strong opioids (10.9%).

The most common therapies used for neuropathic pain treatment are physical therapy, relaxation therapy, massage therapy, psychological therapy, and acupuncture accompanied by pain counseling.

Furthermore, in neuropathic pain caused by medical conditions such as diabetes, treatment may emphasize the management of the condition and improvement of quality of life by preventing further nerve damage.

In some cases, an invasive or implantable device may be used to manage the pain.

Collard Green is a species of Brassica Oleracea, belonging to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

With an aim to find a potential compound for the treatment of neuropathic pain, researchers investigated sulforaphane (SFN), a derivative of glucoraphanin present in cruciferous vegetables on inflammation-related diseases.

According to the tested analysis, SFN showed an anti-nociceptive effect in a neuropathic pain mouse model, sciatic nerve chronic constriction injury (CCI).

Furthermore, SFN injected intraperitoneally for 7 days inhibited pain behaviors, including mechanical allodynia and thermal hyperalgesia in CCI mice.

Moreover, SFN at a dose-dependently also attenuated CCI-induced pain behavioral hypersensitivity, by inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6 that cause neuropathic pain in mice and exhibiting the production of an anti-inflammatory cytokine such as IL-10 associated with pain relief.

More importantly, CCI enhancement of COX2 and iNOS in the induction of nerve injury were also counteracted by the administration of SFN.

Additionally, SFN treatment also increased the CCI-induced increase in µ-opioid receptors that are responsible for the analgesics, in injured sciatic nerves.

Based on the results, researchers said, "SFN has both anti-nociceptive and anti-inflammatory actions"

Taken altogether, collard green processed a high amount of SFN may be considered supplements for the prevention and treatment of neuropathic pain, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-nociceptive and anti-inflammatory actions of sulforaphane in chronic constriction injury-induced neuropathic pain mice by Wang C1, Wang C. (PubMed)
(2) The prevalence of probable neuropathic pain in the US: results from a multimodal general-population health survey by Marco D DiBonaventura,1 Alesia Sadosky,2 Kristen Concialdi,1 Markay Hopps,2 Ian Kudel,1Bruce Parsons,2 Joseph C Cappelleri,3 Patrick Hlavacek,2 Andrea H Alexander,2Brett R Stacey,4 John D Markman,5 and John T Farrar. (PMC)

Risk of Melanoma is Reduced by 3% for Every Cup of Coffee Intake Per Day, Scientists Say

Kyle J. Norton

Intake of coffee regularly may have a positive effect in reducing the risk of Melanoma, particularly in healthy people with alternated genes GSTM1 and GSTT1 expression, a renowned institute study suggested.
Melanoma is a type of malignant skin cancer caused by DNA damage, most often caused by ultraviolet radiation from sunshine or tanning beds inducing irregular growth of skin cells.

Coffee, becoming a popular and social beverage worldwide, particularly in the West, is a drink made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.

According to the Istituto Dermopatico dell Immacolata, in comparison to low coffee intake, high frequency of coffee drinking (>once daily) with ≤7 times weekly, showed a significantly lower risk of melanoma.

Interestingly, in the group of people with GSTM1 and GSTT1 null polymorphisms(altered gene expression) subjects, coffees showed an extremely high protective effect against the forming of Melanoma.


Also in the searching of PubMed and EMBASE databases from the earliest available online indexing year to March 2017 for a dose-response meta-analysis on prospective cohort studies, researchers at the Jagiellonian University Medical College, insisted that linear dose-dependent are associated with the development of melanoma risk and total coffee consumption.

The risk of melanoma is reduced by 3% for every cup of coffee intake per day.

Dr. Micek A, the lead author in the joint study said, "(According to) a total of seven studies eligible for meta-analysis were identified that comprised 1,418,779 participants and 9211 melanoma cases,......coffee intake may be inversely associated with the incidence of melanoma".

Further in the demonstration of 2 case-control studies (846 MM patients and 843 controls) and five cohort studies (including 844,246 participants and 5,737 MM cases), compared to the lower and higher caffeine intake daily, caffeinated coffee showed a pooled relative risk (RR) of 0.81.

Risk of an additional cup of coffee caffeine consumption, the relative odds ratio of the risk of melanoma decreased by 0.955
Importantly, the study found no correlated and linear dose-dependent of decaffeinating coffee and risk of melanoma regardless of the volume of daily intake in teasing subjects.


Taken together, there is no doubt that caffeine coffee has a significant effect in reducing the risk of melanoma in healthy and altered GSTM1 and GSTT1 expression subjects in linearly dose-dependent
manner.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before It's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) The protective effect of coffee consumption on cutaneous melanoma risk and the role of GSTM1 and GSTT1 polymorphisms by Fortes C1, Mastroeni S, Boffetta P, Antonelli G, Pilla MA, Bottà G, Anzidei P, Venanzetti F.(PubMed)
(2) Caffeinated and decaffeinated coffee consumption and melanoma risk: a dose-response meta-analysis of prospective cohort studies by Micek A1, Godos J2, Lafranconi A3, Marranzano M2, Pajak A1(PubMed).

#BroccoliSprout #Extract Sulforaphane Inhibits #Oxidativestress Associated with A Decreased Risk of Cognitive Deficits, Researchers Find

Kyle J. Norton

Cognition is the process of the brain functioning associated with the attention of working memory, producing and comprehending language, learning, reasoning, problem-solving, and decision-making.
Cognitive deficit is a medical condition, that affects a person's thinking, communication, understanding, or memory. The cognitive deficit can be acute or chronic.

Acute cognitive deficit is a short-term health problem caused by drug toxicity and withdrawal, electrolyte disturbance, lack of drugs, liver disease, infection, reduced sensor input, intracranial urinary retention/fecal impaction, or myocardial/metabolic/pulmonary. An acute cognitive deficit may be recovered if the cause is found.

Chronic cognitive deficit is a permanent medical condition caused by the gradual or permanent loss of neurons, leading to problems with language, ideomotor and constructive praxis, visual gnosis, spatial attention, learning abilities, and executive functions.

There is no single cause of the chronic cognitive deficit. An increase in age, genetic preposition, certain medical conditions, such as diabetes, high blood cholesterol, and pressure, obesity and lack of exercise are some prevalent factors found in patients with chronic cognitive deficits.


Some researchers suggested that depending on the locations of the brain that were affected, patients may be at risk of Alzheimer's disease such as brain change caused by the abnormal clumps of beta-amyloid protein (plaques).


Small strokes or reduced blood flow through the brain can also cause a chronic cognitive deficit.

According to the observation of the patient's MRI, the patient's brain with cognitive impairment also showed shrinkage of the hippocampus, a brain region important for memory, enlargement of the brain's fluid-filled spaces (ventricles), and reduced use of glucose, the sugar that's the primary source of energy for cells.

Out of many risk factors associated with the onset of the condition, obesity is also one of the major risk factors for cognitive impairment in the Western world.

Dr. Jason C. D. Nguyen, the lead author on the neurological team wrote in the final report, "The incidence of obesity in middle age is increasing markedly, and in parallel, the prevalence of metabolic disorders including cardiovascular disease and type II diabetes is also rising. Numerous studies have demonstrated that both obesity and metabolic disorders are associated with poorer cognitive performance, cognitive decline, and dementia".

Brussels sprout is a species of wild cabbage (Brassica oleracea), belong to the family of Brassicaceae and has been cultivated since ancient Rome.


With an aim to find a potential compound for the treatment of cognitive impairment, researchers examined the effects of dietary intake of sulforaphane-rich broccoli sprout extracts against parameters associated with the risk of cognitive dysfunction in patients with schizophrenia.

According to the results of the experiment, sulforaphane (SFN) derived from broccoli showed a strong effect in the activation of the transcription factor Nrf2 regulated by Keap1, a cytoplasmic protein that plays a central role against the stimulation of oxidative stress.


Moreover, pretreatment with SFN attenuated cognitive deficit, the increase in 8-oxo-dG-positive cells, and the decrease in PV-positive cells in the medial prefrontal cortex and hippocampus found in patients with a neurodegenerative disease caused by oxidative stress induced by administration of phencyclidine (PCP).


In other words, PCP-induced cognitive deficits were inhibited by the subsequent subchronic administration of SFN.

Believe it or not, chronic dietary intake of glucoraphanin (a glucosinolate precursor of SFN) during juvenile and adolescence not only prevented the onset of PCP-induced cognitive deficit but also increased in 8-oxo-dG-positive cells and the decrease in PV-positive cells in the brain at adulthood.


The results strongly suggested the NRF2 gene and the KEAP1 gene had an epistatic effect in gene reaction on cognitive impairment (e.g., working memory and processing speed) in patients with schizophrenia.

Based on the findings, researchers said, "SFN may have prophylactic and therapeutic effects on cognitive impairment in schizophrenia. Therefore, the dietary intake of SFN-rich broccoli sprouts during juvenile and adolescence may prevent the onset of psychosis in adulthood".

Taken altogether, broccoli sprouts processed abundantly SFN may be considered a functional food for the promotion of cognitive deficit, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood by Shirai Y1, Fujita Y1, Hashimoto R2, Ohi K3, Yamamori H3, Yasuda Y3, Ishima T1, Suganuma H4, Ushida Y4, Takeda M3, Hashimoto K. (PubMed)
(2) Obesity and cognitive decline: role of inflammation and vascular changes by Jason C. D. Nguyen,1 A. Simon Killcross,2 and Trisha A. Jenkins. (PMC)