#Phytochemical #Tartaricacid Shows a Strong Anti-bacterial Activity, Scientists Say

Kyle J. Norton

Phytochemicals may be the next potential source of new medications for the treatment of diseases with little or no side effects.

Tartaric acid, a phytochemical of the organic acid may be considered an alternative antibiotic remedy to replace conventional medicine for the treatment of infectious diseases caused by harmful bacteria, some studies suggested.

Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer color.

Out of millions of bacteria present in this world, only a hundred of them cause infectious diseases. And, most bacteria that cause large-scale disease in human history may be closed to extinction.

In contrast to general belief, most bacteria live as independent cells, they share the basic characteristics of all living things, they breathe, metabolize, produce waste, and maintain a membrane potential.

However, bacteria do not process a nucleus in which their DNA is separated from the rest of the cell.

In the differentiation of bacteria, one must know that not all bacteria are bad. Some bacteria found in the digestive tract have been found to aid digestion and prevent the imbalance of bad and good bacteria. In other words, most bacteria are harmless.

Bacteria can enter our body to cause infection through an open wound, drinking bacterially contaminated water, close contact with infectious patients, or breathing in the exhaled droplets of an infected person.

In order to protect the body against bacterial invasion, the immune white blood cells after sensing the presence of harmful pathogens stimulate the production of pro-inflammatory cytokines to the site of infection with an aim to destroy the bacteria before causing damage to the body.

However, overproduction of proinflammatory cytokines in some cases can also cause the death of healthy cells, leading to improper healing with the formation of scars.


Tartaric acid is a phytochemical of the organic acid found abundantly in nuts, apricots, apples, sunflower, avocado, grapes, etc.

In the finding natural antibiotics without inducing side effects as of those in conventional medicine, researchers at the Mississippi State University conducted an experiment to examine the anti-bacterial effects of the water-soluble extracts prepared from purple (cultivar Ison) and bronze (cultivar Carlos) muscadine seeds with or without heating.


Application of the Ison extracts displayed a strong antimicrobial activity against a cocktail of three strains of Escherichia coli O157: H7.

Chemical analysis suggested the extract had a higher acidity (pH 3.39 to 3.43) compared to normal extract.

The major chemical compounds associated with the antibacterial activity include total phenolics (2.21 to 3.49 mg/ml), tartaric acid (5.6 to 10.7 mg/ml), tannic acid (5.7 to 8.1 mg/ml), and gallic acid (0.33 to 0.59 mg/ml), are also higher than those of the Carlos extracts.

Furthermore, heat treatment on both extracts increased antimicrobial activity, possibly because of increased acidity of the tartaric acid, total phenolics, and individual phenolics.

Heating of Ison extracts increased ellagic acid up to 83%. higher than the minimum of 10.7 mg/ml tartaric acid used alone exerted a strong effect against E. coli O157:H7.

However, up to 10.7 mg/ml tartaric acid alone was not as effective against E. coli O157:H7 as were water-soluble seed extracts.

The ingredients that are responsible for the antibacterial efficacy of the purple (cultivar Ison) and bronze (cultivar Carlos) muscadine seeds are tannic and gallic acids, which process the property of inactivation of pathogens.

Dr. Kim TJ, the lead author, on the final phase of the study, wrote, "Water-soluble muscadine seed extracts may be useful for incorporation into juice and other beverage products as natural preservatives"

Taken together, tartaric acid exerted a significant effect in the inhibition of bacterium may be considered a functional phytochemical for the prevention and an adjunct therapy combined with the primary medicine for the treatment of bacterial infection.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Reference
(1) Antimicrobial effect of water-soluble muscadine seed extracts on Escherichia coli O157:H7.

#Turmeric's #Curcumin Inhibit the Risk of Thyroid Cancer by Increasing the Expression of Tumor Suppressor and Decreasing Overexpression of Vimentin, Scientists Suggest

Kyle J. Norton

Cancer is a group of medical and chronic diseases characterized by cell growth disorderly and uncontrollably in the tissue of specific organs in the body.

Over time, the alternative cells-induced tumor may become progressively worse and damage other healthy tissues, depending on the grade of the tumor.

At the later stage, the most invasive tumor can induce secondary metastasis by spreading to other organs in the body via lymph or blood.

According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes, according to the data from 2013–2015.

In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer, and 1,790 died of the disease.

The thyroid, one of the largest endocrine glands found in the neck, below the Adam's Apple plays an essential role in regulating the use of energy, making proteins, and producing hormones.

Thyroid cancer, the medical condition caused by alternation of the cells in the thyroid gland found 3 times more common in women compared to men, can be classified into 4 most common types
* Papillary thyroid cancer
Papillary thyroid cancer is the most common type of thyroid cancer, accounting for over 80 percent of all cases. It tends to develop in the women's age group between 30-40 years with the tendency to grow slowly.
Papillary thyroid cancer can be treated successfully if diagnosed early.


* Follicular thyroid cancer
Follicular thyroid cancer, the second most common thyroid cancer, accounts for over 15 % of all cases. It is a low-growing cancer with peak onset from ages 40 through 60.
Follicular thyroid cancer can be treated successfully if diagnosed early.

* Medullary thyroid cancer
Medullary thyroid cancer, the third most common thyroid cancer that makes up only 3 percent of all cases, arises from thyroid hormone-producing cells with abnormally high levels of calcitonin. Medullary thyroid cancer tends to grow slowly but it can spread to distant parts of the body, if not treated early.

* Anaplastic thyroid cancer
Anaplastic thyroid cancer is a rare case of thyroid cancer, accounting for less than 2 percent of all cases. It tends to grow and spread very quickly.
Anaplastic thyroid cancer is deadly, with only a 10% survival rate, 3 years after being diagnosed.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In finding a potential ingredient for the treatment of cancer, researchers examined the effect of curcumin on the invasion and metastasis of thyroid cancers.


According to the tested differentiation, curcumin inhibited the multiple metastasis steps of the K1 papillary thyroid cancer cell line.

In a dose-dependent manner, curcumin also suppressed K1 cell viability, attachment, spreading, migration, and invasion abilities.

Furthermore, curcumin could also inhibit the expression and activity of an enzyme associated with cancer cell proliferation.

Based on the findings, researchers said, "Curcumin might be an effective humouristic agent for the treatment of aggressive papillary thyroid carcinomas".

Moreover, in human papillary thyroid carcinoma BCPAP cells, curcumin exerted an anti-thyroid cancer effect by increasing the expression of the tumor suppressor E-cadherin and decreasing the overexpression of vimentin found in various epithelial cancers.

Additionally, curcumin also blocked the activated transforming growth factor -β1 associated with the expression and activity of an enzyme associated with cancer cell proliferation.

Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of thyroid cancer, pending the confirmation of the larger sample size and multicenter human study.


Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin inhibits metastasis in human papillary thyroid carcinoma BCPAP cells via down-regulation of the TGF-β/Smad2/3 signaling pathway by Zhang L1, Cheng X2, Gao Y2, Zhang C3, Bao J2, Guan H4, Yu H2, Lu R5, Xu Q6, Sun Y. (PubMed)
(2) Curcumin inhibits invasion and metastasis in K1 papillary thyroid cancer cells by Zhang CY1, Zhang L, Yu HX, Bao JD, Sun Z, Lu RR. (PubMed)
(3) Thyroid Cancer by Kyle J. Norton

#Sulforaphane (SFN) Isolated from Collard Greens Inhibit Pro-Inflammatory Cytokines Associated with Neuropathic Pain, Researchers Reveal

Kyle J. Norton

Neurological disorders are a class of diseases of the nervous system characterized by structural damage, and biochemical or electrical abnormalities in the brain, spinal cord, or nerves.

Neurodegenerative disease is a type of neurological disorder associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Neuropathic pain is a type of pain that affects the somatosensory nervous system due to damage or disease. Abnormal sensations called dysesthesia or pain from normally non-painful stimuli (allodynia) are some of the most common forms of neuropathic pain found in patients.

There are no obvious causes of neuropathic pain. However, medical conditions such as alcoholism, amputation, diabetes, nerve problems, HIV infection or AIDS, multiple myeloma, multiple sclerosis and shingles, and chemotherapy are some prevalent factors of neuropathic pain.

According to the joint study conducted by the Health Outcomes Practice, there are no published data on the broad prevalence of neuropathic pain (NeP) in the US. However, the 15,751 respondents reported pain (63.7%), of 2,548 data suggested that 10% of Americans may suffer from neuropathic pain (NeP). The rate of NeP in Blacks and Hispanics ethnicity was consistently higher compared to White


Most common treatments of NeP are the use of nonsteroidal anti-inflammatory drugs (44.2%), followed by weak opioids (31.7%), antiepileptics (10.9%), and strong opioids (10.9%).

The most common therapies used for neuropathic pain treatment are physical therapy, relaxation therapy, massage therapy, psychological therapy, and acupuncture accompanied by pain counseling.

Furthermore, in neuropathic pain caused by medical conditions such as diabetes, treatment may emphasize the management of the condition and improvement of quality of life by preventing further nerve damage.

In some cases, an invasive or implantable device may be used to manage the pain.

Collard Green is a species of Brassica Oleracea, belonging to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

With an aim to find a potential compound for the treatment of neuropathic pain, researchers investigated sulforaphane (SFN), a derivative of glucoraphanin present in cruciferous vegetables on inflammation-related diseases.

According to the tested analysis, SFN showed an anti-nociceptive effect in a neuropathic pain mouse model, sciatic nerve chronic constriction injury (CCI).

Furthermore, SFN injected intraperitoneally for 7 days inhibited pain behaviors, including mechanical allodynia and thermal hyperalgesia in CCI mice.

Moreover, SFN at a dose-dependently also attenuated CCI-induced pain behavioral hypersensitivity, by inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6 that cause neuropathic pain in mice and exhibiting the production of an anti-inflammatory cytokine such as IL-10 associated with pain relief.

More importantly, CCI enhancement of COX2 and iNOS in the induction of nerve injury were also counteracted by the administration of SFN.

Additionally, SFN treatment also increased the CCI-induced increase in µ-opioid receptors that are responsible for the analgesics, in injured sciatic nerves.

Based on the results, researchers said, "SFN has both anti-nociceptive and anti-inflammatory actions"

Taken altogether, collard green processed a high amount of SFN may be considered supplements for the prevention and treatment of neuropathic pain, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-nociceptive and anti-inflammatory actions of sulforaphane in chronic constriction injury-induced neuropathic pain mice by Wang C1, Wang C. (PubMed)
(2) The prevalence of probable neuropathic pain in the US: results from a multimodal general-population health survey by Marco D DiBonaventura,1 Alesia Sadosky,2 Kristen Concialdi,1 Markay Hopps,2 Ian Kudel,1Bruce Parsons,2 Joseph C Cappelleri,3 Patrick Hlavacek,2 Andrea H Alexander,2Brett R Stacey,4 John D Markman,5 and John T Farrar. (PMC)

Risk of Melanoma is Reduced by 3% for Every Cup of Coffee Intake Per Day, Scientists Say

Kyle J. Norton

Intake of coffee regularly may have a positive effect in reducing the risk of Melanoma, particularly in healthy people with alternated genes GSTM1 and GSTT1 expression, a renowned institute study suggested.
Melanoma is a type of malignant skin cancer caused by DNA damage, most often caused by ultraviolet radiation from sunshine or tanning beds inducing irregular growth of skin cells.

Coffee, becoming a popular and social beverage worldwide, particularly in the West, is a drink made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.

According to the Istituto Dermopatico dell Immacolata, in comparison to low coffee intake, high frequency of coffee drinking (>once daily) with ≤7 times weekly, showed a significantly lower risk of melanoma.

Interestingly, in the group of people with GSTM1 and GSTT1 null polymorphisms(altered gene expression) subjects, coffees showed an extremely high protective effect against the forming of Melanoma.


Also in the searching of PubMed and EMBASE databases from the earliest available online indexing year to March 2017 for a dose-response meta-analysis on prospective cohort studies, researchers at the Jagiellonian University Medical College, insisted that linear dose-dependent are associated with the development of melanoma risk and total coffee consumption.

The risk of melanoma is reduced by 3% for every cup of coffee intake per day.

Dr. Micek A, the lead author in the joint study said, "(According to) a total of seven studies eligible for meta-analysis were identified that comprised 1,418,779 participants and 9211 melanoma cases,......coffee intake may be inversely associated with the incidence of melanoma".

Further in the demonstration of 2 case-control studies (846 MM patients and 843 controls) and five cohort studies (including 844,246 participants and 5,737 MM cases), compared to the lower and higher caffeine intake daily, caffeinated coffee showed a pooled relative risk (RR) of 0.81.

Risk of an additional cup of coffee caffeine consumption, the relative odds ratio of the risk of melanoma decreased by 0.955
Importantly, the study found no correlated and linear dose-dependent of decaffeinating coffee and risk of melanoma regardless of the volume of daily intake in teasing subjects.


Taken together, there is no doubt that caffeine coffee has a significant effect in reducing the risk of melanoma in healthy and altered GSTM1 and GSTT1 expression subjects in linearly dose-dependent
manner.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before It's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) The protective effect of coffee consumption on cutaneous melanoma risk and the role of GSTM1 and GSTT1 polymorphisms by Fortes C1, Mastroeni S, Boffetta P, Antonelli G, Pilla MA, Bottà G, Anzidei P, Venanzetti F.(PubMed)
(2) Caffeinated and decaffeinated coffee consumption and melanoma risk: a dose-response meta-analysis of prospective cohort studies by Micek A1, Godos J2, Lafranconi A3, Marranzano M2, Pajak A1(PubMed).

#BroccoliSprout #Extract Sulforaphane Inhibits #Oxidativestress Associated with A Decreased Risk of Cognitive Deficits, Researchers Find

Kyle J. Norton

Cognition is the process of the brain functioning associated with the attention of working memory, producing and comprehending language, learning, reasoning, problem-solving, and decision-making.
Cognitive deficit is a medical condition, that affects a person's thinking, communication, understanding, or memory. The cognitive deficit can be acute or chronic.

Acute cognitive deficit is a short-term health problem caused by drug toxicity and withdrawal, electrolyte disturbance, lack of drugs, liver disease, infection, reduced sensor input, intracranial urinary retention/fecal impaction, or myocardial/metabolic/pulmonary. An acute cognitive deficit may be recovered if the cause is found.

Chronic cognitive deficit is a permanent medical condition caused by the gradual or permanent loss of neurons, leading to problems with language, ideomotor and constructive praxis, visual gnosis, spatial attention, learning abilities, and executive functions.

There is no single cause of the chronic cognitive deficit. An increase in age, genetic preposition, certain medical conditions, such as diabetes, high blood cholesterol, and pressure, obesity and lack of exercise are some prevalent factors found in patients with chronic cognitive deficits.


Some researchers suggested that depending on the locations of the brain that were affected, patients may be at risk of Alzheimer's disease such as brain change caused by the abnormal clumps of beta-amyloid protein (plaques).


Small strokes or reduced blood flow through the brain can also cause a chronic cognitive deficit.

According to the observation of the patient's MRI, the patient's brain with cognitive impairment also showed shrinkage of the hippocampus, a brain region important for memory, enlargement of the brain's fluid-filled spaces (ventricles), and reduced use of glucose, the sugar that's the primary source of energy for cells.

Out of many risk factors associated with the onset of the condition, obesity is also one of the major risk factors for cognitive impairment in the Western world.

Dr. Jason C. D. Nguyen, the lead author on the neurological team wrote in the final report, "The incidence of obesity in middle age is increasing markedly, and in parallel, the prevalence of metabolic disorders including cardiovascular disease and type II diabetes is also rising. Numerous studies have demonstrated that both obesity and metabolic disorders are associated with poorer cognitive performance, cognitive decline, and dementia".

Brussels sprout is a species of wild cabbage (Brassica oleracea), belong to the family of Brassicaceae and has been cultivated since ancient Rome.


With an aim to find a potential compound for the treatment of cognitive impairment, researchers examined the effects of dietary intake of sulforaphane-rich broccoli sprout extracts against parameters associated with the risk of cognitive dysfunction in patients with schizophrenia.

According to the results of the experiment, sulforaphane (SFN) derived from broccoli showed a strong effect in the activation of the transcription factor Nrf2 regulated by Keap1, a cytoplasmic protein that plays a central role against the stimulation of oxidative stress.


Moreover, pretreatment with SFN attenuated cognitive deficit, the increase in 8-oxo-dG-positive cells, and the decrease in PV-positive cells in the medial prefrontal cortex and hippocampus found in patients with a neurodegenerative disease caused by oxidative stress induced by administration of phencyclidine (PCP).


In other words, PCP-induced cognitive deficits were inhibited by the subsequent subchronic administration of SFN.

Believe it or not, chronic dietary intake of glucoraphanin (a glucosinolate precursor of SFN) during juvenile and adolescence not only prevented the onset of PCP-induced cognitive deficit but also increased in 8-oxo-dG-positive cells and the decrease in PV-positive cells in the brain at adulthood.


The results strongly suggested the NRF2 gene and the KEAP1 gene had an epistatic effect in gene reaction on cognitive impairment (e.g., working memory and processing speed) in patients with schizophrenia.

Based on the findings, researchers said, "SFN may have prophylactic and therapeutic effects on cognitive impairment in schizophrenia. Therefore, the dietary intake of SFN-rich broccoli sprouts during juvenile and adolescence may prevent the onset of psychosis in adulthood".

Taken altogether, broccoli sprouts processed abundantly SFN may be considered a functional food for the promotion of cognitive deficit, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood by Shirai Y1, Fujita Y1, Hashimoto R2, Ohi K3, Yamamori H3, Yasuda Y3, Ishima T1, Suganuma H4, Ushida Y4, Takeda M3, Hashimoto K. (PubMed)
(2) Obesity and cognitive decline: role of inflammation and vascular changes by Jason C. D. Nguyen,1 A. Simon Killcross,2 and Trisha A. Jenkins. (PMC)

#Asparagus Root #Extract Processes #Antidepression Activity by Inhibiting Free Radical Over-Expression Researchers Say

Kyle J. Norton

Scientists may have found a dietary vegetable that processes a strong and profound impact in ameliorating psychological depression, a recent study suggested.
Depression is a common psychological disease that affects your normal feelings, thinking, and reactions to events that occur daily in your life.

People with depression may feel ashamed or afraid to ask for help. others suffer in silence.

According to the statistics of the World Health Organization, 300 million people around the world have depression. The number of Americans who suffer from depression is increasing at an alarming rate. As of today, 16.2 million adults in the United States, or 6.7% of all adults have depression in the country.

Women are more susceptible to developing depression than men and fewer than half of those affected by depression in the world are seeking professional treatment.

The disease is the leading cause of disability worldwide and a major contributor to the overall global burden of diseases.

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness. Over 30 million

Contrary to some misconceptions, depression can be treated and avoidable.

What causes depression? is debatable, however, genetic predisposition, personality, stress and brain chemistry are found to be associated with the onset of the disease.

Chronic medical conditions also can trigger the development of depression. According to the study by the Shanghai University of Sport in the review of 60 articles with a total of 4311 patients, chronic diseases are highly correlated to the expression of depression and reduced quality of life(5).

The study also suggested that increasing the SF-36 physical function subscale in such patients in the short and long term may have a profound and positive effect in ameliorated depression and improved quality of life.

The use of antidepressants by conventional medicine may be effective. However, they can induce side effects of an upset stomach, insomnia, sexual problems, anxiety, dizziness,....., and fatigue.

In severe cases, the intake of depressants may cause serotonin syndrome, seizures, irregular heartbeat, and unconsciousness and some people in the group under the age of 25 may experience suicidal thoughts, according to the BBC report By Lesley Ashmall(6).

Asparagus is a flowering plant, belonging to the species genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, northwest Germany, northern Africa, and Western Asia.

The vegetable has been used from early times as a food and medicine, because of its delicate flavor and diuretic properties.

In an oral administration of methanolic extract of roots of AR (MAR) of the doses of 100, 200, and 400 mg/kg daily for 7 days and then subjected to a forced swim test(FST) in mice, researchers found that application of the extract decreases immobility in FST and increases avoidance response in learned helplessness test (LH), an indication of antidepressant activity.

Dr. Singh GK, the lead author said, " MAR had an insignificant effect on l-DOPA-induced aggressive behavior indicating the absence of activity on the dopaminergic system" and "MAR has significant antidepressant activity and this effect is probably mediated through the serotonergic and the noradrenergic systems and augmentation of antioxidant defenses".

Furthermore, the injection of extracts of Asparagus cochinchinensis (AC) also expressed antidepressive effects, through inhibited oxidative stress that causes neuron cell damage and improved cell signal response and signal transmission.

Total saponin isolated from AC significantly is found to inhibit the free radical of H2O2 in the induction of cell death in cultured cortical neurons.

Additional analysis suggested that AC antidepressant-like and neuroprotective (reducing infarct size) effects are associated with the activation of Shp-2 pathways which are associated with the inhibition of depression in an animal model.

Some researchers suggested that the antidepression activity of Asparagus racemosus (AR) may also be mediated by the neurotransmitter system, and cognitive activities possibly through the cholinergic system involved neuromuscular junctions, preganglionic neurons of the sympathetic nervous system...

Moreover, the study also showed that AR may be used as food and have potential drug-drug, drug-food, and food-food interactions with drugs and foods, sharing the cholinergic and monoaminergic pathways in sending a message between neurons, induced protective activities against the development of depression.

These results suggested that asparagus ameliorated depression with its neuroprotective effect by inhibited free radicals that cause neuro-cell damage and improved cell signal response.

However, further data collection on large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of asparagus anti-depression possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antidepressant activity of Asparagus racemosus in rodent models by Singh GK1, Garabadu D, Muruganandam AV, Joshi VK, Krishnamurthy S.(PubMed)
(2) The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies by Jalsrai A1, Numakawa T2, Kunugi H2, Dieterich DC3, Becker A4. (PubMed)
(3) Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes by Meena J1, Ojha R, Muruganandam AV, Krishnamurthy S.(PubMed)
(4) Behavioural and neurochemical evaluation of Perment an herbal formulation in chronic unpredictable mild stress induced depressive model by Ramanathan M1, Balaji B, Justin A.(PubMed)
(5) Effect of traditional Chinese exercise on the quality of life and depression for chronic diseases: a meta-analysis of randomised trials by Wang X1,2, Pi Y3, Chen B1, Chen P1, Liu Y4, Wang R4, Li X1, Zhu Y5, Yang Y6, Niu Z(PubMed)
(6) The 'extreme' side-effects of antidepressants By Lesley Ashmall

#Herbal #Turmeric's #Curcumin Inhibits Kidney Inflammation and the Onset of #LupusNephritis, Researchers Suggest

Kyle J. Norton

Lupus nephritis is a condition of kidneys an inflammation caused by systemic lupus erythematosus (SLE), an autoimmune disease.
It is a type of glomerulonephritis in which the glomeruli become inflamed.

Kidneys are a pair of bean-shaped organs, located just below the rib cage, one on each side of your spine with a function to filter out blood toxins through urinary secretion.

Believe it or not, every day, the blood passes the kidneys many times. Some people with only 10% of kidney function showed no symptoms of toxin accumulation.


However, if the kidney fails to cleanse the blood due to kidney failure, patients may experience symptoms of decreased urine output, and fluid retention in their legs, ankles, or feet.


Depending on the severity of toxins accumulation, some patients may also experience symptoms of shortness of breath and confusion.

Lupus nephritis reduced kidney function may cause symptoms of sudden and unexplained swelling of feet, ankles, legs, fingers, arms or eyes, foamy appearance in urine, and frequent urination.

In severe cases, patients may also have symptoms of blood in urine and elevated blood pressure.

Out of many risk factors associated with the risk of lupus nephritis, some researchers suggested genetic preposition may have a strong impact that leads to the early onset of the disease.

Dr. the lead scientist wrote, " Although many SLE susceptibility genes have been identified, the genetic basis of LN is not as well understood".


And, "some of the established general SLE susceptibility genes are associated with LN, recent discoveries highlight a number of genes with renal functions that are specifically associated with LN. Some of these genes associated with LN help to explain the disparity in the prevalence of nephritis between individuals with SLE, and also partially explain differences in LN between ancestral backgrounds".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In finding a potential ingredient for the treatment of lupus nephritis, researchers investigated the effects of curcumin on lupus nephritis (LN) induced animal model.

LN established New Zealand Black/White (NZB/W) F1 female mice, at 18 weeks of age were fed a standard diet or a diet containing 1 % curcumin until the end of the study.

During the study, infection of curcumin decreased the proteinuria level and serum levels of IgG1, IgG2a which were elevated in LN mice.


Where proteinuria is the ratio of a protein/creatinine greater than 45 mg/mmol and high levels of IgG1, IgG2a is an indication of immune defect.

Additionally, curcumin also protected the kidneys against inflammation by reducing the anti-dsDNA IgG antibodies which were also elevated in NZB/W F1 female mice.


Where elevated levels of anti-dsDNA IgG antibodies are associated with ongoing inflammation and damage to the kidneys.

Furthermore, IgG immune complex deposition in the glomeruli was also reduced in curcumin-treated mice.

In other words, curcumin suppressed the pro-inflammatory expression in the kidney glomeruli.

Moreover, according to the kidney-tested assays, kidney inflammation was also decreased after curcumin treatment.

More importantly, researchers discovered that treatment with anti-CD25 antibody injection that causes Treg depletion also affects the therapeutic effects of curcumin.

The anti-CD25 antibody is a conventional medicine used for enhancing the immune response.

More precisely, curcumin cannot be used in combination with anti-CD25 antibody daclizumab that
targets the T cells for the treatment of lupus nephritis.

Based on the findings, researchers said, "Curcumin exerted a protective effect against LN in NZB/W F1 mice. We speculate that the protective effects of curcumin in LN may involve, at least in part, its interaction with Treg cells".

Taken together, turmeric-processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of lupus nephritis, pending the confirmation of the larger sample size and multicenter human study.


Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice by Lee H1, Kim H, Lee G, Chung HS, Bae H. (PubMed)
(2) Genetics of human lupus nephritis by Iwamoto T1, Niewold TB. (PubMed)