Kyle J. Norton
Recent studies suggested that coffee and coffee caffeine may have a potential effect in reducing the risk and treatment of breast cancer, selectively.
Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.
The review of literature from the database of PubMed with selection of 37 published articles, involving 59,018 breast cancer cases and 966,263 participants, suggested that
1. There is no significant association between coffee and coffee caffeine intake and breast cancer risk
2. Post menopause women drinking coffee daily and regularly have a reduced risk of breast cancer developing.
3. Women who are BRCA1 mutation carriers showed a positive risk of breast cancer from coffee intake
The study also indicated that for an additional cup of coffee consumed risk of breast cancer decreased by 2% and 1% for every 200mg/day increment in caffeine intake.
Contrastively, in a case-control analysis on 1,690 women with a BRCA1 or BRCA2 mutation from 40 centers in 4 countries.to determine coffee and coffee caffeine intake against the risk of breast cancer, returned self-administered questionnaire. showed a significant correlation of coffee intake in the elevated breast caner risk.
Women with breast cancer in BRCA carriers who habitually drank 0, 1-3, 4-5 and 6 or more cups of coffee showed a relative risk odds ratio of 1.00, 0.90, 0.75, and 0.31, respectively.
The finding evidence of a relatively odd ratio suggested that the risk of breast cancer was reduced in this group of women linearly to the number of coffee and coffee caffeine consumed daily.
Dr, Jiang W, lead author said, " (According to the findings) women with BRCA gene mutation, coffee consumption is unlikely to be harmful and that high levels of consumption may in fact be related to reduced breast cancer risk"
Interesting, in the investigated the common A to C polymorphism in the CYP1A2 gene associated with decreased enzyme inducibility and impaired caffeine metabolism of caffeine to examine the risk of breast cancer in BRCA1 mutation carriers of 411 BRCA1 mutation carriers (170 cases and 241 controls) researchers at the University of Toronto found that risk of breast cancer decrease significantly by 64% in BRCA1 mutation carriers with at least one C polymorphism in the CYP1A2 gene but not in CYP1A2 AA group in compared to women who never consumed coffee.
Collectively, coffee and coffee caffeine may only benefit certain ages and gene expression but are harmful to others. Further cohort studies are necessary to clarify these controversies.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Coffee and caffeine intake and breast cancer risk: an updated dose-response meta-analysis of 37 published studies by Jiang W1, Wu Y, Jiang X.(PubMed)
(2) Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers by Nkondjock A1, Ghadirian P, Kotsopoulos J, Lubinski J, Lynch H, Kim-Sing C, Horsman D, Rosen B, Isaacs C, Weber B, Foulkes W, Ainsworth P, Tung N, Eisen A, Friedman E, Eng C, Sun P, Narod SA.(PubMed)
(3) The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers by Kotsopoulos J1, Ghadirian P, El-Sohemy A, Lynch HT, Snyder C, Daly M, Domchek S, Randall S, Karlan B, Zhang P, Zhang S, Sun P, Narod SA.(PubMed)
Tuesday, 12 September 2023
#Fennel Inhibits Proteins and Expression Associated with Liver Against Toxicity and Diseases Through Its Antioxidant Activities, Scientists Suggest
Kyle J. Norton
Fennel may be considered a functional food in exhibited liver protective effect against toxicity, some scientists suggested.
Liver protection is an action that prevents injury and damage to the liver, regardless of the causes.
Researchers do not know the exact cause of liver disease. However, they do know that genes inherited from the parents, aging, and viral and bacterial infection are associated with the increased risk of liver disease.
Additionally, long-term excessive alcohol drinking and obesity are also some prevalent risk factors for the onset of liver disease.
Untreated liver disease or liver disease that is not treated properly over time can increase the risk of cirrhosis, a leading cause of liver failure and a life-threatening condition.
Dr. William Nseir, the lead author in the assessment of the role of diet and lifestyle changes in nonalcoholic fatty liver disease wrote, "A combination of dietary modifications and increased physical activity remains the mainstay of NAFLD management. It is hard to maintain this mode of management; however, it seems to have significant long-term benefits" "Furthermore, NAFLD patients, whether obese or not, should be educated that a healthy diet and physical activity have benefits beyond weight reduction".
These results suggested that a change in diet and lifestyle with moderate exercise may have a strong effect on the prevention of liver disease.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
In the evaluation of the liver protective effect against acute hepatotoxicity induced by carbon tetrachloride (CLL4) in the rat model, researchers found that oral administration of essential oil isolated from the fennel exerts a strong activity in the decrease of levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and bilirubin, the potential causes of liver damage through their toxic effects.
Further analysis insisted that the hepatoprotective activity of the essential oil was attributed to the expression of phytochemical constituents d-limonene and β-myrcene in the inhibition of the levels of carbon tetrachloride in catalyzing liver toxicity and initiating liver lesion and liver fibrosis.
Additional differentiation of the hepatic fibrosis model in rats induced by subcutaneous injection with 40% CCl4 olive oil mixture with 94 male SD rats given high lipoid-low protein animal feeds for 5 weeks then randomly divided into six groups, including blank control group (A-group), 8 rats were feed in normal, prevention model control group (B-group), 10 rats given saline solution by intragastric administration during the make of hepatic fibrosis model and FVM prevention group (C-group), 10 rats given FVM by intragastric administration during make of hepatic fibrosis model; model control group (D-group), FVM treatment group (E-group) and Fuzhenghuayu treatment group (F-group), after assessing the results from the 5-th weekend, A, B, C- group rats sacrificed at the 6-th, 7-th, 8-th, 9-th weekend and 4-6 rats in D, E, F-group sacrificed., researchers indicated that
* The expression of alpha-smooth muscle actin(a-SMA) associated with liver damage and correlated positively in the recurrent HCV hepatitis group are significantly higher in the HBV cirrhosis detected by immunohistochemical staining assay.
* Serum alanine aminotransferase (ALT), an amino acid found in proteins and intermediate in cellular energy production presented in the blood of tested subjects may be an indication of liver damage.
Low levels of ALT are found in the blood profiles of healthy individuals.
* Similar to ALT, aspartate aminotransferase (AST) is an enzyme associated with the liver parenchymal cell and presented in low levels in the blood of healthy individuals but significantly higher in liver damage-tested rats.
* Hyaluronic acid (HA) is distributed widely throughout connective, epithelial, and neural tissues, the prediction of liver damage, particularly in the risk of liver fibrosis.
* Increased levels of Laminin (LN), a protein of the extracellular matrix, are also associated with a substantial risk of the development of liver fibrosis.
* Overexpression of levels of 8 - hydroxy-2-deoxyguanosine (8-OHdG) is another indication of oxidative stress and is also considered a critical biomarker of carcinogenesis.
The increased levels of the above expressions suggested substantial damage to the liver caused by ingestion of CCL4 in the non-fennel treatment group.
However, the application of fennel in such groups inhibited the overexpression of toxicity caused by the injection of CCL4 by restoring the normal levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), laminin (LN), and 8 - hydroxy-2-deoxyguanosine (8-OHdG).
Further analysis also showed that oral administration of fennel inhibited the levels of malondialdehyde (MDA) in precipitated oxidative stress through lipid peroxidation.
Some researchers suggested that levels of MDA may be used as a biomarker in the assessment of oxidative stress status in patients with liver disease or cancer.
Moreover, injection of fennel exerted liver protective and anti-inflammatory effects through its antioxidants overexpression and improved production of natural antioxidants in the host tissue such as superoxide dismutase (SOD), glutathione peroxidase levels in inhibited oxidative stress initiated by CCL4
Precisely, fennel significantly decreased expression serums of ALT, AST, HA, LN and MDA, 8-OHdG, fiber, and a-SMA expression in the FVM group and lowered inflammation grade and fibrosis stage compared to the control group.
Dr. Zhang ZG, the lead author, after taking into account other co-founders said, "Foeniculum Vulgare Mill declines liver inflammation response, and prevents the hepatic fibrosis progression,, this may be due to its effects of antioxidative results".
The findings suggested that fennel with abundant bioactive anethole may be considered a functional food in exhibited hepatoprotective effect through its anti-inflammatory and antioxidant activities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatoprotective effect of Foeniculum vulgare essential oil by Ozbek H1, Uğraş S, Dülger H, Bayram I, Tuncer I, Oztürk G, Oztürk A.(PubMed)
(2) [Antioxidant effects of the Uygur herb, Foeniculum Vulgare Mill, in a rat model of hepatic fibrosis].[Article in Chinese] by Zhang ZG1, Lu XB, Xiao L, Tang L, Zhang LJ, Zhang T, Zhan XY, Ma XM, Zhang YX(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
Fennel may be considered a functional food in exhibited liver protective effect against toxicity, some scientists suggested.
Liver protection is an action that prevents injury and damage to the liver, regardless of the causes.
Researchers do not know the exact cause of liver disease. However, they do know that genes inherited from the parents, aging, and viral and bacterial infection are associated with the increased risk of liver disease.
Additionally, long-term excessive alcohol drinking and obesity are also some prevalent risk factors for the onset of liver disease.
Untreated liver disease or liver disease that is not treated properly over time can increase the risk of cirrhosis, a leading cause of liver failure and a life-threatening condition.
Dr. William Nseir, the lead author in the assessment of the role of diet and lifestyle changes in nonalcoholic fatty liver disease wrote, "A combination of dietary modifications and increased physical activity remains the mainstay of NAFLD management. It is hard to maintain this mode of management; however, it seems to have significant long-term benefits" "Furthermore, NAFLD patients, whether obese or not, should be educated that a healthy diet and physical activity have benefits beyond weight reduction".
These results suggested that a change in diet and lifestyle with moderate exercise may have a strong effect on the prevention of liver disease.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
In the evaluation of the liver protective effect against acute hepatotoxicity induced by carbon tetrachloride (CLL4) in the rat model, researchers found that oral administration of essential oil isolated from the fennel exerts a strong activity in the decrease of levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and bilirubin, the potential causes of liver damage through their toxic effects.
Further analysis insisted that the hepatoprotective activity of the essential oil was attributed to the expression of phytochemical constituents d-limonene and β-myrcene in the inhibition of the levels of carbon tetrachloride in catalyzing liver toxicity and initiating liver lesion and liver fibrosis.
Additional differentiation of the hepatic fibrosis model in rats induced by subcutaneous injection with 40% CCl4 olive oil mixture with 94 male SD rats given high lipoid-low protein animal feeds for 5 weeks then randomly divided into six groups, including blank control group (A-group), 8 rats were feed in normal, prevention model control group (B-group), 10 rats given saline solution by intragastric administration during the make of hepatic fibrosis model and FVM prevention group (C-group), 10 rats given FVM by intragastric administration during make of hepatic fibrosis model; model control group (D-group), FVM treatment group (E-group) and Fuzhenghuayu treatment group (F-group), after assessing the results from the 5-th weekend, A, B, C- group rats sacrificed at the 6-th, 7-th, 8-th, 9-th weekend and 4-6 rats in D, E, F-group sacrificed., researchers indicated that
* The expression of alpha-smooth muscle actin(a-SMA) associated with liver damage and correlated positively in the recurrent HCV hepatitis group are significantly higher in the HBV cirrhosis detected by immunohistochemical staining assay.
* Serum alanine aminotransferase (ALT), an amino acid found in proteins and intermediate in cellular energy production presented in the blood of tested subjects may be an indication of liver damage.
Low levels of ALT are found in the blood profiles of healthy individuals.
* Similar to ALT, aspartate aminotransferase (AST) is an enzyme associated with the liver parenchymal cell and presented in low levels in the blood of healthy individuals but significantly higher in liver damage-tested rats.
* Hyaluronic acid (HA) is distributed widely throughout connective, epithelial, and neural tissues, the prediction of liver damage, particularly in the risk of liver fibrosis.
* Increased levels of Laminin (LN), a protein of the extracellular matrix, are also associated with a substantial risk of the development of liver fibrosis.
* Overexpression of levels of 8 - hydroxy-2-deoxyguanosine (8-OHdG) is another indication of oxidative stress and is also considered a critical biomarker of carcinogenesis.
The increased levels of the above expressions suggested substantial damage to the liver caused by ingestion of CCL4 in the non-fennel treatment group.
However, the application of fennel in such groups inhibited the overexpression of toxicity caused by the injection of CCL4 by restoring the normal levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), laminin (LN), and 8 - hydroxy-2-deoxyguanosine (8-OHdG).
Further analysis also showed that oral administration of fennel inhibited the levels of malondialdehyde (MDA) in precipitated oxidative stress through lipid peroxidation.
Some researchers suggested that levels of MDA may be used as a biomarker in the assessment of oxidative stress status in patients with liver disease or cancer.
Moreover, injection of fennel exerted liver protective and anti-inflammatory effects through its antioxidants overexpression and improved production of natural antioxidants in the host tissue such as superoxide dismutase (SOD), glutathione peroxidase levels in inhibited oxidative stress initiated by CCL4
Precisely, fennel significantly decreased expression serums of ALT, AST, HA, LN and MDA, 8-OHdG, fiber, and a-SMA expression in the FVM group and lowered inflammation grade and fibrosis stage compared to the control group.
Dr. Zhang ZG, the lead author, after taking into account other co-founders said, "Foeniculum Vulgare Mill declines liver inflammation response, and prevents the hepatic fibrosis progression,, this may be due to its effects of antioxidative results".
The findings suggested that fennel with abundant bioactive anethole may be considered a functional food in exhibited hepatoprotective effect through its anti-inflammatory and antioxidant activities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hepatoprotective effect of Foeniculum vulgare essential oil by Ozbek H1, Uğraş S, Dülger H, Bayram I, Tuncer I, Oztürk G, Oztürk A.(PubMed)
(2) [Antioxidant effects of the Uygur herb, Foeniculum Vulgare Mill, in a rat model of hepatic fibrosis].[Article in Chinese] by Zhang ZG1, Lu XB, Xiao L, Tang L, Zhang LJ, Zhang T, Zhan XY, Ma XM, Zhang YX(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
#Enzyme #Bromelain Inhibits Proteins Associated with Anti Apoptotic and Proliferative Signaling Against #Cholangiocarcinoma (CC), Researchers Say
Kyle J. Norton
Cholangiocarcinoma, also known as bile duct cancer, is a medical condition that originated from irregular cell growth in the bile ducts.
Most cases of cholangiocarcinoma are caused by the alternation of cell DNA in the cell on the surface of the inner lining of the bile duct.
At the advanced stage, cancer cells in the bile duct may travel a distance away to infect other healthy tissues and organs through the circulation of blood and fluids.
Primary bile duct cancer has been found to spread to the regional lymph nodes and adjacent organs.
According to statistics, cholangiocarcinoma is a rare cancer that occurs in approximately 2,500 Americans each year compared to 5,000 cases of gallbladder cancer and 15,000 cases of hepatocellular cancer.
Believe it or not, the 5-year survival rate diagnosed with early-stage extrahepatic bile duct cancer is only 30%. If cancer has spread to the regional lymph nodes, the 5-year survival rate is 24%.
The most common type of cholangiocarcinoma found in the bile duct is perihilar cholangiocarcinoma, followed by the distal extra-hepatic and then the intrahepatic forms.
Epidemiologically parasitic infections, primary sclerosing cholangitis, biliary-duct cysts, hepatolithiasis, and toxins are some prevalent factors that cause the onset of cholangiocarcinoma.
Dr. Gia L. Tyson, the lead scientist wrote, "Cholangiocarcinoma is the second most common primary hepatic malignancy after hepatocellular cancer. It accounts for approximately 10–25% of all hepatobiliary malignancies".
And, "Other less-established, potential risk factors include inflammatory bowel disease, hepatitis C virus, hepatitis B virus, cirrhosis, diabetes, obesity, alcohol drinking, tobacco smoking, and host genetic polymorphisms".
However, most people with some of the above risk factors do not develop cholangiocarcinoma.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient against Cholangiocarcinoma (CC), researchers investigated the anticancer effect of bromelain and papain in intra- and extrahepatic human CC cell lines.
According to the medical assays, bromelain and papain showed a similar effect inhibition of human CC cell growth, migration, and invasion.
Furthermore, according to cell proliferative assays, bromelain and papain resulted in a decrease in the proliferation, invasion, and migration of CC cells.
Bromelain and papain-induced CC death by inhibiting protein-associated anti-apoptotic signaling as well as their downstream signaling proteins associated with CC proliferation.
Interestingly, compared to papain, bromelain showed an overall more effective inhibition of CC.
In additional differentiation of the anti-cancer activity, researchers found that bromelain and papain have cytotoxic effects on human CC cells.
Based on the findings, Dr. Müller A the lead scientist said, "Bromelain and papain have cytotoxic effects on human CC cell lines, and bromelain and partially papain in comparison impair tumor growth by NFκB/AMPK signaling".
And, " Especially bromelain can evolve as a promising, potential therapeutic option that might open new insights for the treatment of human CC".
Taken altogether, bromelain may be considered a supplement for the prevention and treatment of cholangiocarcinoma, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines by Müller A1, Barat S1, Chen X1, Bui KC1, Bozko P1, Malek NP1, Plentz RR. (PubMed)
(2) Risk Factors of Cholangiocarcinoma by Gia L. Tyson, MD and Hashem B. El-Serag, MD, MPH. (PMC)
Cholangiocarcinoma, also known as bile duct cancer, is a medical condition that originated from irregular cell growth in the bile ducts.
Most cases of cholangiocarcinoma are caused by the alternation of cell DNA in the cell on the surface of the inner lining of the bile duct.
At the advanced stage, cancer cells in the bile duct may travel a distance away to infect other healthy tissues and organs through the circulation of blood and fluids.
Primary bile duct cancer has been found to spread to the regional lymph nodes and adjacent organs.
According to statistics, cholangiocarcinoma is a rare cancer that occurs in approximately 2,500 Americans each year compared to 5,000 cases of gallbladder cancer and 15,000 cases of hepatocellular cancer.
Believe it or not, the 5-year survival rate diagnosed with early-stage extrahepatic bile duct cancer is only 30%. If cancer has spread to the regional lymph nodes, the 5-year survival rate is 24%.
The most common type of cholangiocarcinoma found in the bile duct is perihilar cholangiocarcinoma, followed by the distal extra-hepatic and then the intrahepatic forms.
Epidemiologically parasitic infections, primary sclerosing cholangitis, biliary-duct cysts, hepatolithiasis, and toxins are some prevalent factors that cause the onset of cholangiocarcinoma.
Dr. Gia L. Tyson, the lead scientist wrote, "Cholangiocarcinoma is the second most common primary hepatic malignancy after hepatocellular cancer. It accounts for approximately 10–25% of all hepatobiliary malignancies".
And, "Other less-established, potential risk factors include inflammatory bowel disease, hepatitis C virus, hepatitis B virus, cirrhosis, diabetes, obesity, alcohol drinking, tobacco smoking, and host genetic polymorphisms".
However, most people with some of the above risk factors do not develop cholangiocarcinoma.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient against Cholangiocarcinoma (CC), researchers investigated the anticancer effect of bromelain and papain in intra- and extrahepatic human CC cell lines.
According to the medical assays, bromelain and papain showed a similar effect inhibition of human CC cell growth, migration, and invasion.
Furthermore, according to cell proliferative assays, bromelain and papain resulted in a decrease in the proliferation, invasion, and migration of CC cells.
Bromelain and papain-induced CC death by inhibiting protein-associated anti-apoptotic signaling as well as their downstream signaling proteins associated with CC proliferation.
Interestingly, compared to papain, bromelain showed an overall more effective inhibition of CC.
In additional differentiation of the anti-cancer activity, researchers found that bromelain and papain have cytotoxic effects on human CC cells.
Based on the findings, Dr. Müller A the lead scientist said, "Bromelain and papain have cytotoxic effects on human CC cell lines, and bromelain and partially papain in comparison impair tumor growth by NFκB/AMPK signaling".
And, " Especially bromelain can evolve as a promising, potential therapeutic option that might open new insights for the treatment of human CC".
Taken altogether, bromelain may be considered a supplement for the prevention and treatment of cholangiocarcinoma, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines by Müller A1, Barat S1, Chen X1, Bui KC1, Bozko P1, Malek NP1, Plentz RR. (PubMed)
(2) Risk Factors of Cholangiocarcinoma by Gia L. Tyson, MD and Hashem B. El-Serag, MD, MPH. (PMC)
Monday, 11 September 2023
#Bromelain Inhibits Free Radicals Associated with a Reduced Risk of #Oxidativestress, According to Studies
Kyle J. Norton
Antioxidants are stable molecules that play an essential role in the inhibition of oxidation caused by free radicals.
Free radicals are unstable and highly reactive molecules with a single electron in the outermost ring. Therefore, in order to maintain stability, free radicals either donate or intercept an electron from other stable molecules, leading to a chain of reaction that can not be stopped until all single electron in the outermost ring is paired or inhibited by antioxidants.
Overexpression of free radicals and reduced production of antioxidant enzymes by the body induce oxidative stress. Over time, oxidative stress can cause protein, lipid, and cell damage, leading to chronic diseases, including cardiovascular disease and diabetes.
There are 2 types of antioxidants. antioxidants enzymes produced by the liver and the dietary sources, including
* Antioxidant enzymes from dietary protein and minerals, including superoxide dismutase (SOD), glutathione peroxidase, glutathione reductase, and catalases.
* Antioxidant vitamins found in supplements or daily intake of food. such as vitamins A, C, E, folic acid, and beta-carotene. Most antioxidant vitamins process a free radical scavenging activity.
In other words, they gobble up free radicals before they can cause a chain of reaction.
* Antioxidant phytochemicals are found mostly in the plant's second metabolites including fruits and vegetables, carotenoids, flavonoids, allyl sulfides, and polyphenols.
Believe it or not, in a healthy individual, antioxidants produced by the liver are more than enough to balance the production of free radicals. However, in people with a weakened immune system, intake of antioxidants from dietary sources and supplements may be necessary.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential ingredient for the treatment of disease associated with oxidative stress, researchers evaluated the ameliorative efficacy of bacoside A and bromelain on oxidative stress biomarkers in the serum of dichlorvos-intoxicated mice.
The experiment included mice were allocated into six groups. The first group received saline as a vehicle; the second group was administered with dichlorvos (40 mg/kg b.w.); the third group was administered with bromelain (70 mg/kg b.w.), the fourth group received a dose of bacoside A (5 mg/kg b.w.), the fifth group was given concomitant exposure of bacoside A and bromelain both and mice of the sixth group were exposed to bacoside A, bromelain and dichlorvos for 21 days consecutively.
The group treated with dichlorvos showed a significant increase in oxidative stress biomarkers thiobarbituric acid reactive substances (TBARS) and protein carbonyl content (PCC).
The results suggested that dichlorvos stimulates the production of free radicals in mice.
Bromelain and dichlorvos treated group showed a strong effect in the inhibition of the free radical expression induced by dichlorvos.
Furthermore, co-administration of bromelain and bacoside A in dichlorvos-exposed mice also displayed a significant effect in reversing the level of CAT, SOD, GPx, and GSH (p < 0.05) which was decreased due to the dichlorvos administration.
Based on the findings, researchers said, "Findings of research conclude that concomitant exposure of bacoside A and bromelain was much effective in combating oxidative stress induced by dichlorvos".
Taken together, bromelain may be considered a supplement for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bacoside A and bromelain relieve dichlorvos induced changes in oxidative responses in mice serum by Agarwal S1, Chaudhary B2, Bist R. (PubMed)
Antioxidants are stable molecules that play an essential role in the inhibition of oxidation caused by free radicals.
Free radicals are unstable and highly reactive molecules with a single electron in the outermost ring. Therefore, in order to maintain stability, free radicals either donate or intercept an electron from other stable molecules, leading to a chain of reaction that can not be stopped until all single electron in the outermost ring is paired or inhibited by antioxidants.
Overexpression of free radicals and reduced production of antioxidant enzymes by the body induce oxidative stress. Over time, oxidative stress can cause protein, lipid, and cell damage, leading to chronic diseases, including cardiovascular disease and diabetes.
There are 2 types of antioxidants. antioxidants enzymes produced by the liver and the dietary sources, including
* Antioxidant enzymes from dietary protein and minerals, including superoxide dismutase (SOD), glutathione peroxidase, glutathione reductase, and catalases.
* Antioxidant vitamins found in supplements or daily intake of food. such as vitamins A, C, E, folic acid, and beta-carotene. Most antioxidant vitamins process a free radical scavenging activity.
In other words, they gobble up free radicals before they can cause a chain of reaction.
* Antioxidant phytochemicals are found mostly in the plant's second metabolites including fruits and vegetables, carotenoids, flavonoids, allyl sulfides, and polyphenols.
Believe it or not, in a healthy individual, antioxidants produced by the liver are more than enough to balance the production of free radicals. However, in people with a weakened immune system, intake of antioxidants from dietary sources and supplements may be necessary.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential ingredient for the treatment of disease associated with oxidative stress, researchers evaluated the ameliorative efficacy of bacoside A and bromelain on oxidative stress biomarkers in the serum of dichlorvos-intoxicated mice.
The experiment included mice were allocated into six groups. The first group received saline as a vehicle; the second group was administered with dichlorvos (40 mg/kg b.w.); the third group was administered with bromelain (70 mg/kg b.w.), the fourth group received a dose of bacoside A (5 mg/kg b.w.), the fifth group was given concomitant exposure of bacoside A and bromelain both and mice of the sixth group were exposed to bacoside A, bromelain and dichlorvos for 21 days consecutively.
The group treated with dichlorvos showed a significant increase in oxidative stress biomarkers thiobarbituric acid reactive substances (TBARS) and protein carbonyl content (PCC).
The results suggested that dichlorvos stimulates the production of free radicals in mice.
Bromelain and dichlorvos treated group showed a strong effect in the inhibition of the free radical expression induced by dichlorvos.
Furthermore, co-administration of bromelain and bacoside A in dichlorvos-exposed mice also displayed a significant effect in reversing the level of CAT, SOD, GPx, and GSH (p < 0.05) which was decreased due to the dichlorvos administration.
Based on the findings, researchers said, "Findings of research conclude that concomitant exposure of bacoside A and bromelain was much effective in combating oxidative stress induced by dichlorvos".
Taken together, bromelain may be considered a supplement for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bacoside A and bromelain relieve dichlorvos induced changes in oxidative responses in mice serum by Agarwal S1, Chaudhary B2, Bist R. (PubMed)
#Herbal #Angelica Sinensis Inhibits #Liverstress Maekers Associated with LiverToxicity and Injury, Researchers Show
Kyle J. Norton
The liver is the largest internal organ in the human body and the only organ that can regenerate itself. The liver is the first line of the bodily toxin defense by filtering the blood that comes from the digestive tract, before passing it to the rest of the body.
The liver also produces cholesterol that plays a critical role in building strong cell membranes, producing steroid hormones and vitamin D, and aiding the digestive function in food absorption and detoxifying chemicals, and metabolizing drugs.
The hepatoprotective or liver protective effect is an action that maintains the liver's healthy functioning against any harmful toxins, including detoxification which is a natural process of our body to maintain the proper function and protect our organs and tissues against toxicity by eliminating toxins accumulated.
When they fail, the toxic accumulations cause a disruption of hormone production, damage the body's detoxification organs, and weaken the immune system, leading to hormone imbalance and chronic illness consequently.
Symptoms of liver diseases include jaundice, abdominal pain, swelling, swelling in the legs and ankles, itchy skin, dark urine, pale stool color, and a tendency to bruise easily.
There are no exact causes of liver disease. viruses, toxins, genetics, alcohol, and unknown causes are some prevalent factors found in patients with chronic liver disease, including cancer.
In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.
Furthermore, in recent years, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.
In finding a natural ingredient for the prevention and treatment of liver diseases, scientists examined the hepatoprotective effects of polysaccharides-enriched fractions from the root of Angelica sinensis in rodents.
Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to the tested analysis,
* Intra-gastric administration of Angelica sinensis polysaccharides-enriched fraction (AP) at the doses of 50 or 75 mg/kg dose-dependently prevented liver toxicity induced by acetaminophen in mice but did not affect the serum acetaminophen concentration.
* AP inhibited the liver stress markers alanine transferase (ALT), malondialdehyde (MDA) hepatic nitric oxide synthase (NOS) activities, and glutathione level in the liver.
* In the carbon tetrachloride (CCl4) induced liver damage animals, AP showed weak protective activity.
* However, a higher dose of AP inhibited the MDA level without affecting the serum ALT level, the hepatic glutathione level instead while the NOS activity in CCl4 induced liver damage in rats.
Based on the results, researchers suggest, "These findings suggest that the pathogenic mechanisms of both acetaminophen and CCl4 are different. AP is more effective in the protection against liver damage induced by acetaminophen, which is associated with glutathione depletion and nitric oxide synthase activation in the liver".
Taken together, Dandelion may be considered a remedy for the protection against liver damage, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury by Ye YN1, Liu ES, Li Y, So HL, Cho CC, Sheng HP, Lee SS, Cho CH. (PubMed)
(2) Protection of Angelica sinensis (Oliv) Diels against hepatotoxicity induced by Dioscorea bulbifera L. and its mechanism by Niu C1, Wang J, Ji L, Wang Z. (PubMed)
The liver is the largest internal organ in the human body and the only organ that can regenerate itself. The liver is the first line of the bodily toxin defense by filtering the blood that comes from the digestive tract, before passing it to the rest of the body.
The liver also produces cholesterol that plays a critical role in building strong cell membranes, producing steroid hormones and vitamin D, and aiding the digestive function in food absorption and detoxifying chemicals, and metabolizing drugs.
The hepatoprotective or liver protective effect is an action that maintains the liver's healthy functioning against any harmful toxins, including detoxification which is a natural process of our body to maintain the proper function and protect our organs and tissues against toxicity by eliminating toxins accumulated.
When they fail, the toxic accumulations cause a disruption of hormone production, damage the body's detoxification organs, and weaken the immune system, leading to hormone imbalance and chronic illness consequently.
Symptoms of liver diseases include jaundice, abdominal pain, swelling, swelling in the legs and ankles, itchy skin, dark urine, pale stool color, and a tendency to bruise easily.
There are no exact causes of liver disease. viruses, toxins, genetics, alcohol, and unknown causes are some prevalent factors found in patients with chronic liver disease, including cancer.
In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.
Furthermore, in recent years, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.
In finding a natural ingredient for the prevention and treatment of liver diseases, scientists examined the hepatoprotective effects of polysaccharides-enriched fractions from the root of Angelica sinensis in rodents.
Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to the tested analysis,
* Intra-gastric administration of Angelica sinensis polysaccharides-enriched fraction (AP) at the doses of 50 or 75 mg/kg dose-dependently prevented liver toxicity induced by acetaminophen in mice but did not affect the serum acetaminophen concentration.
* AP inhibited the liver stress markers alanine transferase (ALT), malondialdehyde (MDA) hepatic nitric oxide synthase (NOS) activities, and glutathione level in the liver.
* In the carbon tetrachloride (CCl4) induced liver damage animals, AP showed weak protective activity.
* However, a higher dose of AP inhibited the MDA level without affecting the serum ALT level, the hepatic glutathione level instead while the NOS activity in CCl4 induced liver damage in rats.
Based on the results, researchers suggest, "These findings suggest that the pathogenic mechanisms of both acetaminophen and CCl4 are different. AP is more effective in the protection against liver damage induced by acetaminophen, which is associated with glutathione depletion and nitric oxide synthase activation in the liver".
Taken together, Dandelion may be considered a remedy for the protection against liver damage, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury by Ye YN1, Liu ES, Li Y, So HL, Cho CC, Sheng HP, Lee SS, Cho CH. (PubMed)
(2) Protection of Angelica sinensis (Oliv) Diels against hepatotoxicity induced by Dioscorea bulbifera L. and its mechanism by Niu C1, Wang J, Ji L, Wang Z. (PubMed)
#Herbal #Angelica Sinensis Inhibits Genes Associated With Weight Gain, According to Studies
Kyle J. Norton
Obesity is a medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.
According to the Body Mass Index(BMI), people who have a BMI between 25 to 29.9 are considered overweight and a BMI of over 30 is an indication of obesity.
The formula of the BMI indexBMI= weight (kg)/ height (m2)
According to the statistics, 68% of the American population is either overweight or obese. However,
In 2016, more than 1.9 billion adults, 18 years and older, were overweight, including over 650 million who were obese worldwide.
Visceral fat obesity is associated with 90% of patients with ischemic heart disease. In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.
Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.
However, in non-obese subjects, visceral fat accumulation is correlated with glucose intolerance, hyperlipidemia, and hypertension.
Obesity rates have increased for all age groups in the US over the last several decades, coincidently with the periods that promoted the Western diet.
Weight gain is an increase in body weight associated with some parameters, including increased muscle mass, fat deposits, excess fluids such as water, or other factors.
However, weight gain has also been found to be induced by serious medical conditions.
In finding a natural ingredient for the prevention and treatment of obesity, scientists examined the radix Angelica sinensis (RAS) suppressed body weight by altering the expression of the fat mass and obesity-associated (FTO) gene in an animal model.
Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to tested analysis in mice fed with high-fat diet (HFD)-induced obesity,
* 36 differentially expressed genes (DEGs) associated with the increased onset of obesity were found in adipose tissues from the RAS supplementation group (DH) and control group (HC).
* Six out of the 36 DEGs identified to be involved in lipid metabolism, with the APOA2 gene a potential anti-obesogenic influence were inhibited by the injection of RAS compared to control.
In other words, RAS supplementation in HFD-induced obese mice was associated with an anti-obesogenic global transcriptomic response.
Based on the results, researchers suggest, "This study provides insight into potential applications of RAS in obesity therapy".
Taken altogether, Dandelion may be considered a remedy for the treatment of weight gain in obese, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-obesity effect of radix Angelica sinensis and candidate causative genes in transcriptome analyses of adipose tissues in high-fat diet-induced mice by Zhong T1, Zhang H1, Duan X1, Hu J1, Wang L1, Li L1, Zhang H1, Niu L. (PubMed)
Obesity is a medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.
According to the Body Mass Index(BMI), people who have a BMI between 25 to 29.9 are considered overweight and a BMI of over 30 is an indication of obesity.
The formula of the BMI indexBMI= weight (kg)/ height (m2)
According to the statistics, 68% of the American population is either overweight or obese. However,
In 2016, more than 1.9 billion adults, 18 years and older, were overweight, including over 650 million who were obese worldwide.
Visceral fat obesity is associated with 90% of patients with ischemic heart disease. In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.
Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.
However, in non-obese subjects, visceral fat accumulation is correlated with glucose intolerance, hyperlipidemia, and hypertension.
Obesity rates have increased for all age groups in the US over the last several decades, coincidently with the periods that promoted the Western diet.
Weight gain is an increase in body weight associated with some parameters, including increased muscle mass, fat deposits, excess fluids such as water, or other factors.
However, weight gain has also been found to be induced by serious medical conditions.
In finding a natural ingredient for the prevention and treatment of obesity, scientists examined the radix Angelica sinensis (RAS) suppressed body weight by altering the expression of the fat mass and obesity-associated (FTO) gene in an animal model.
Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to tested analysis in mice fed with high-fat diet (HFD)-induced obesity,
* 36 differentially expressed genes (DEGs) associated with the increased onset of obesity were found in adipose tissues from the RAS supplementation group (DH) and control group (HC).
* Six out of the 36 DEGs identified to be involved in lipid metabolism, with the APOA2 gene a potential anti-obesogenic influence were inhibited by the injection of RAS compared to control.
In other words, RAS supplementation in HFD-induced obese mice was associated with an anti-obesogenic global transcriptomic response.
Based on the results, researchers suggest, "This study provides insight into potential applications of RAS in obesity therapy".
Taken altogether, Dandelion may be considered a remedy for the treatment of weight gain in obese, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-obesity effect of radix Angelica sinensis and candidate causative genes in transcriptome analyses of adipose tissues in high-fat diet-induced mice by Zhong T1, Zhang H1, Duan X1, Hu J1, Wang L1, Li L1, Zhang H1, Niu L. (PubMed)
#Xuebijing Supplemention Injection (XBJ) Including #Angelica Reduces the Mortality Rate in Patients with Sepsis, Researchers Find
Kyle J. Norton
Sepsis is a condition caused by chemicals released into the bloodstream to fight the infection that triggers inflammation throughout the body as a result of severe infection(a)(b). According to a study by the University of Utah, sepsis is the commonest cause of admission to medical ICUs across the world.
Mortality from sepsis continues to be high. Besides shock and multi-organ dysfunction occurring following the intense inflammatory reaction to sepsis, complications arising from sepsis-related immunoparalysis contribute to the morbidity and mortality from sepsis(c).
The most common risk factors associated with the prevalent factors of sepsis, term infants, while very low birth weight (VLBW) and preterm infants, obesity, operative vaginal delivery and age <25 years, elderly, patients in intensive care and with the weakened immune system, invasive devices, and alcoholism.
Diseases associated with Sepsis are
* Staphylococcal infections
Preterm infants are especially susceptible to late-onset sepsis which is often due to Gram-positive bacterial infections resulting in substantial morbidity and mortality(24).
* Elevated central venous pressure
Elevated central venous pressure is associated with impairment of microcirculatory blood flow in sepsis(25).
* Neonatal cellulitis
There is a report of a case of late-onset neonatal invasive group A streptococcal disease characterized by rapidly progressing cellulitis and development of sepsis(26).
* Methicillin-resistant Staphylococcus aureus
There is a report of the spectrum of community-acquired S. aureus infections and to compare the patients infected with methicillin-susceptible or methicillin-resistant strains among patients aged <20 years. Overall, 90 cases of community-acquired S. aureus were detected in an 11-year period(27).
* Bladder infection
Bladder bacteria is a common but unique cause of sepsis(28).
* Urinary tract infection
In the study to evaluate the effectiveness of Lactobacillus GG supplementation in reducing the incidence of urinary tract infections (UTIs), bacterial sepsis, and necrotizing enterocolitis (NEC) in preterm infants, found that seven days of Lactobacillus GG supplementation starting with the first feed is not effective in reducing the incidence of UTIs, NEC, and sepsis in preterm infants. Further studies are required to confirm our results in lower birth weight populations(29).
In finding a natural ingredient for the prevention and treatment of infectious diseases, scientists examined the effects of Xuebijing injection (XBJ), a Chinese patent medicine on sepsis.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to the search of medical literature in Embase, PubMed, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Journal Database (VIP), and the Wanfang database from inception to June 6, 2017, including relevant RCTs comparing XBJ combined with RT and RT alone for sepsis, * 1602 records and 16 RCTs (1144 patients) identified suggested that the combined therapy reduced 28-day mortality and body temperature.
* WBC count improved with combined medication at high dosages (one study included, 40/1144, MD -8.00, 95% CI -10.18 to -5.82) with no reduction at moderate dosages.
* However, moderate-quality evidence indicated positive results with low dosages.
Based on the results, researchers suggest, "This study suggested that supplementation with XBJ in addition to regular treatment may improve the 28-day mortality rate, APACHE Ⅱ scores, WBC count, and body temperature of sepsis patients without serious adverse events".
Taken together, angelica used combined with other herbal medicines may be considered a remedy for the treatment of sepsis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy and safety of Xuebijing injection (a Chinese patent) for sepsis: A meta-analysis of randomized controlled trials by Li C1, Wang P2, Zhang L3, Li M4, Lei X5, Liu S6, Feng Z7, Yao Y8, Chang B9, Liu B10, Shang H. (PubMed)
(2) Thyroid disease: Euthyroid sick syndrome as a result of Sepsis - Diseases associated with Sepsis by Kyle J. Norton
Sepsis is a condition caused by chemicals released into the bloodstream to fight the infection that triggers inflammation throughout the body as a result of severe infection(a)(b). According to a study by the University of Utah, sepsis is the commonest cause of admission to medical ICUs across the world.
Mortality from sepsis continues to be high. Besides shock and multi-organ dysfunction occurring following the intense inflammatory reaction to sepsis, complications arising from sepsis-related immunoparalysis contribute to the morbidity and mortality from sepsis(c).
The most common risk factors associated with the prevalent factors of sepsis, term infants, while very low birth weight (VLBW) and preterm infants, obesity, operative vaginal delivery and age <25 years, elderly, patients in intensive care and with the weakened immune system, invasive devices, and alcoholism.
Diseases associated with Sepsis are
* Staphylococcal infections
Preterm infants are especially susceptible to late-onset sepsis which is often due to Gram-positive bacterial infections resulting in substantial morbidity and mortality(24).
* Elevated central venous pressure
Elevated central venous pressure is associated with impairment of microcirculatory blood flow in sepsis(25).
* Neonatal cellulitis
There is a report of a case of late-onset neonatal invasive group A streptococcal disease characterized by rapidly progressing cellulitis and development of sepsis(26).
* Methicillin-resistant Staphylococcus aureus
There is a report of the spectrum of community-acquired S. aureus infections and to compare the patients infected with methicillin-susceptible or methicillin-resistant strains among patients aged <20 years. Overall, 90 cases of community-acquired S. aureus were detected in an 11-year period(27).
* Bladder infection
Bladder bacteria is a common but unique cause of sepsis(28).
* Urinary tract infection
In the study to evaluate the effectiveness of Lactobacillus GG supplementation in reducing the incidence of urinary tract infections (UTIs), bacterial sepsis, and necrotizing enterocolitis (NEC) in preterm infants, found that seven days of Lactobacillus GG supplementation starting with the first feed is not effective in reducing the incidence of UTIs, NEC, and sepsis in preterm infants. Further studies are required to confirm our results in lower birth weight populations(29).
In finding a natural ingredient for the prevention and treatment of infectious diseases, scientists examined the effects of Xuebijing injection (XBJ), a Chinese patent medicine on sepsis.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
According to the search of medical literature in Embase, PubMed, the Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Journal Database (VIP), and the Wanfang database from inception to June 6, 2017, including relevant RCTs comparing XBJ combined with RT and RT alone for sepsis, * 1602 records and 16 RCTs (1144 patients) identified suggested that the combined therapy reduced 28-day mortality and body temperature.
* WBC count improved with combined medication at high dosages (one study included, 40/1144, MD -8.00, 95% CI -10.18 to -5.82) with no reduction at moderate dosages.
* However, moderate-quality evidence indicated positive results with low dosages.
Based on the results, researchers suggest, "This study suggested that supplementation with XBJ in addition to regular treatment may improve the 28-day mortality rate, APACHE Ⅱ scores, WBC count, and body temperature of sepsis patients without serious adverse events".
Taken together, angelica used combined with other herbal medicines may be considered a remedy for the treatment of sepsis, pending the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy and safety of Xuebijing injection (a Chinese patent) for sepsis: A meta-analysis of randomized controlled trials by Li C1, Wang P2, Zhang L3, Li M4, Lei X5, Liu S6, Feng Z7, Yao Y8, Chang B9, Liu B10, Shang H. (PubMed)
(2) Thyroid disease: Euthyroid sick syndrome as a result of Sepsis - Diseases associated with Sepsis by Kyle J. Norton
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