#Dried Cranberries Inhibit Parameters Associated a Reduced Symptoms of #InflammatoryBowelDiseases (IBD), Researchers Reveal

Kyle J. Norton

Colitis is a medical condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.

Most cases of colitis are caused by infection, such as bacteria like C. difficile, viruses, and parasites, and inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis (UC).

However, according to the study by the Catholic University of the Sacred Heart, depending on the causes, colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis.

The most common symptoms of colitis are abdominal pain and diarrhea, bleeding per rectum, distention with bloody diarrhea, abdominal bloating and flatulence, and changes in bowel habits.

In severe cases, patients may also experience symptoms of elevated liver enzymes, leukopenia, thrombocytopenia, severe peripheral arthralgias, and chronic watery diarrhea.

Believe it or not, fifty-five percent of patients stated that UC symptoms over the past year had affected their quality of life, while physicians and nurses estimated that 35% to 37% of patients would have a reduced quality of life.

Conventionally, treatments for colitis are totally dependent on the type and severity of the condition. For example, in patients with inflammatory bowel disease (IBD), Self-care at home through home tele-management, Web-guided therapy, and pain management are the most common approaches accompanied by biological therapy, if necessary.

Some researchers suggested the promotion of the Western diet over the past few decades may be the leading cause of colitis in patients with IBD.

Dr. Jimmy K. Limdi wrote, "The parallelism between “westernization” and particularly high dietary intakes of total fat (particularly animal fats, ω-6 polyunsaturated fatty acids (PUFA), milk fats), refined sugars, meat and lower intakes of fruit and vegetables, implicates diet in the great risk of developing IBD".

And, "Diet may influence intestinal inflammation through several biologically plausible mechanisms including dietary antigen presentation, alterations in the gut microbiome, the mucosal immune system and epithelial barrier function among others".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry is cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine for the treatment of wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of IBD, researchers examined the effects of cranberry products on preventing dextran sulfate sodium-induced murine colitis.

According to the tested differentiation, both cranberry extract and dried cranberries-fed groups had significant activity against the disease index.

However, dried cranberries were more effective in preventing colitis compared to that of cranberry extract.

Moreover, both cranberry applications also showed a significant effect in preventing the shortening of colon length,

Biomarkers associated with inflammatory bowel diseases (IBD) such as colonic myeloperoxidase activity were attenuated in animals fed dried cranberries compared to the controls.


Additionally, dried cranberries also inhibited much better results against the production of pro-inflammatory cytokines caused by the injection of dextran sulfate sodium, compared to the controls.

Based on the findings, researchers wrote, "The current report suggests that cranberries can be applied to prevent and reduce the symptoms of IBD".

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of colitis in IBD patients, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Diets enriched with cranberry beans alter the microbiota and mitigate colitis severity and associated inflammation by Monk JM1, Lepp D2, Zhang CP1, Wu W2, Zarepoor L1, Lu JT1, Pauls KP3, Tsao R2, Wood GA4, Robinson LE5, Power KA. (PubMed)
(2) Preventive effects of cranberry products on experimental colitis induced by dextran sulfate sodium in mice by Xiao X1, Kim J1, Sun Q1, Kim D2, Park CS3, Lu TS4, Park Y. (PubMed)
(3) Colitides by Tortora A1, Purchiaroni F, Scarpellini E, Ojetti V, Gabrielli M, Vitale G, Giovanni G, Gasbarrini A. (PubMed)
(4) Dietary practices and inflammatory bowel disease by Jimmy K. Limdi. (PMC)

#Carotenoids Inhibit the Risk of #Liverdiseases through Its Antioxidant Activity, Researchers Find

Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.
The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by the partial or complete function of the liver, including liver failure.

The most common types of liver disease in the US are
* Hepatitis C (26%) is a liver disease caused by liver inflammation caused by viral Hepatitis C, leading to irreversible liver scars. Over time, the condition can also induce liver cancer.

* Alcoholic liver disease (21%) is a condition that causes long-term excessive alcohol drinking. It is known that years of alcohol abuse can cause the liver to become inflamed and swollen. Over time, it has been found to induce the formation of liver scars, known as cirrhosis. Cirrhosis is the final stage of liver disease.

* Hepatitis C plus alcoholic liver disease (15%)

* Cryptogenic causes (18%) is a condition with no apparent underlying reason. However, most researchers suggested that many cases of cryptogenic cirrhosis are likely caused by non-alcoholic fatty liver disease (NAFLD), a condition of fat accumulated in the liver.

* Hepatitis B and D (15%) are liver diseases caused by liver inflammation caused by viral Hepatitis C, leading to irreversible liver scars. Over time, the condition can also induce liver cancer.

The most common symptoms of liver disease are jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine color, pale stool color, bloody or tar-colored stool, chronic fatigue, and nausea or vomiting.

Carotenoids are a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.

On finding a natural ingredient for the treatment of chronic liver diseases, researchers examined the effects of carotenoids against reactive oxygen species and oxidative damage associated with the onset of liver damage.

Overexpression of free radical-induced oxidative stress in the liver not only induced lipid and protein oxidation but also caused the alternation of the liver cell DNA, leading to reduced function of the liver.

Dietary carotenoids as antioxidants not only protected the liver's cellular metabolism but also balance the ratio of free radicals in the liver, thus preventing the onset of liver oxidative stress, the major cause of chronic liver disease, including cancer.

In other words, carotenoids enhance liver functioning by inactivating reactive oxygen species and obstructing lipid and protein oxidative damage, the vital prophylactic strategic molecules.

In chemical differentiation,
* β-Carotene supplementation enhanced the levels of antioxidants in the tested subject that act as free radical scavengers such as vitamin C, glutathione, and glutathione-related enzymes against liver toxicity caused by the administration of aflatoxin-B1.

Furthermore, β-Carotene also inhibited liver disease associated with both HBV and HCV by suppressing the elevation of inflammatory and oxidative conditions in hepatocytes.

* Lycopene found abundantly in tomato and products of tomato possesses antioxidant, and detoxification abilities in many epidemiological and animal studies, thus preventing liver oxidative stress-induced chronic diseases.

* Lutein, another phytochemical and bioactive compound found in carotenoids has been found epidemiologically to possess a strong antioxidant activity by promoting the production liver antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione, against diseases associated with oxidative stress including antiviral activity against hepatitis B.

* Other carotenoids such as β-Cryptoxanthin, α-carotene, fucoxanthin, and zeaxanthin also show promising effects against chronic liver injury through their antioxidant activity.

Taken together, betacyanins used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of adjuvant rheumatic diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination,
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Role of Dietary Carotenoids in Different Etiologies of Chronic Liver Diseases By Uzma Latief and Riaz Ahmad

#Turmeric's #Curcuminoid (CUR) and #Extracts Exert #AntiAging Effects through Their Antioxidant Activities, Researchers Say

Kyle J. Norton

Aging is a natural and biological process that cannot be prevented. Skin aging is one of the most visible processes that occurs constantly in our skin organs.

However, actively engaging healthy living lifestyle by increasing the intake of good healthy food such as whole grains, fruits, vegetables, beans, and legumes, etc., and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc. accompanied with moderate exercise has been found to delay aging progression.

In other words, it is possible that a person is physiologically younger than his or her biological age.

There are many theory that explains the aging process. According to the free radical theory, oxidative damage to the enzymes, other proteins, unsaturated fatty acids, phospholipids, DNA and RNA, etc., caused by free radical chain reaction can lead to aging of the organisms by attacking the lipid bilayers of the cell walls.

You can view other theories of aging by clicking this link.

There are many risk factors associated with aging and premature aging processes. Dr. Bhatt N in the assessment of the risk factors and self-perception for facial aging among the Nepalese population wrote, "Around 50% of attendees were conscious about facial health, 53% perceived their facial age as their chronological age, 39% used some facial care products, and 68% were aware of the risk factors for facial aging".

"The major perceived risk factors were unhealthy eating habits, stress, less exercise, dehydration, diseased state, and sleeping habits. A significant association was found between increasing age, place of birth in hills or mountains, and sun exposure with high wrinkling score".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

In finding a better compound for the treatment of skin aging, researchers determined the antiaging activity of Curcuma heyneana to prove its traditional use as skincare, for cosmetic and body freshness.

In vitro, according to the tested assay, the extracts showed a dose-dependent manner in the final concentration range from 62.5 to 500 µg/mL in the inhibition of free radical expression and 31.25 to 250 µg/mL for tyrosinase and collagenase.

The extract containing a high amount of curcuminoid (CUR), the active principle of Curcuma is the best antioxidant, that acts as a tyrosinase inhibitor, and collagenase inhibitor, compared to those with a low concentration of CUR.

The topical application of the crude extract also induced significant improvement effects on the UV-induced skin structure damage.


By examining the efficacy of constituents of the extracts, researchers found that total CUR content was correlated with the anti-aging activity.

Based on the findings, researchers said, "The results show that C. heyneana contains antioxidant compounds and has potent anti-aging activity, indicating that it can be used as an anti-aging drug candidate or as a photo-cosmeceutical".

Taken altogether, turmeric in the form of an extract may be considered a supplement used for the treatment of skin aging, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-aging properties of Curcuma heyneana Valeton & Zipj: A scientific approach to its use in Javanese tradition by Kusumawati I1, Kurniawan KO2, Rullyansyah S2, Prijo TA3, Widyowati R2, Ekowati J4, Hestianah EP5, Maat S6, Matsunami K7. (PubMed)
(2) Development and evaluation of topical films containing phytoestrogenic diaryheptanoids from Curcuma comosa extract by Tuntiyasawasdikul S1, Limpongsa E1, Jaipakdee N1, Sripanidkulchai B. (PubMed)
(3) Risk factors and self-perception for facial aging among Nepalese population by Bhatt N1, Agrawal S1, Mehta K. (PubMed)

#Cranberry In the Promotion of #CardiometabolicHealth, Researchers Suggest

Kyle J. Norton

Cardiometabolic risk is a condition that estimates the possibility of developing atherosclerotic cardiovascular (CV) disease and diabetes mellitus.

Cardioprotection is a process including the use of substances associated with the preservation of the function and viability of cardiac muscle tissue by the reintroduction of oxygenic blood flow back to the tissues.

Cardiovascular disease (CVD) is a group of conditions caused by the underlying damage of blood vessels and the heart.

More precisely, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack), or stroke, depending on the location of the blockage or disruption,

According to the statistics provided by the American Heart Association, approximately 84 million people in the US live with some form of cardiovascular disease. The condition has also been found to cause the death of about 2,200 people a day.

Atherosclerosis is a medical condition caused by plaque accumulated on the wall of arteries, leading to the narrowing of the artery and reducing oxygen risk blood flow to the heart and brain.

Depending on the location of the blockage, if the reduced blood flow occurs in the brain, it will cause the death of the brain cells, leading to stroke.

However, if the reduced blood flow occurs in the heart, it will cause damage to the heart tissues, leading to heart disease.

The most common disease associated with atherosclerosis is coronary artery disease. Plaques are made up of cholesterol, calcium, and other chemical substances in the artery

Most people with atherosclerosis are asymptomatic at the early stage.

Diabetes is a medical condition characterized by insufficient insulin in the bloodstream. or insulins in the bloodstream are not used properly to convert glucose to energy.

Epidemiologically, diabetes is caused by either the beta cells in the pancreas died-off or insulin receptors with a function that uses insulin to convert glucose to energy clogged up by fat or cholesterol.

In a healthy individual, after eating, the rise of blood glucose triggers the production of insulin by the pancreas into bloodstream After you eat, your blood sugar (glucose) rises. This rise in glucose triggers your pancreas to release insulin into the bloodstream that travels through the blood to your body's cells before converting glucose into energy or storing it for use later.

In other words, insulin is released by the pancreas joints with the Insulin receptors on the outer part of a cell that binds insulin in the blood to convert glucose to energy.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of cardiometabolic health, researchers examined the effect of Vaccinium berry fruit in modulating gut microbiota function and cardiometabolic risk factors.

In cardiometabolic health, cranberry constituents and their bioactive catabolites improved the
serum lipid profiles reduced the levels of blood pressure.


Furthermore, the endothelial functions associated with vascular relaxation contraction, and glucoregulation are involved in the regulation of glucose metabolism. and a variety of biomarkers associated with inflammation and oxidative stress in the induction of CVD and diabetes were also inhibited by the cranberry constituents and their bioactive catabolites

Based on the findings, researchers said, " These results warrant further research, particularly studies dedicated to the elucidation of dose-response relations, pharmacokinetic/metabolomics profiles, and relevant biomarkers of action with the use of fully characterized cranberry products.".

Taken altogether, cranberry may be considered a remedy for the improvement of cardiometabolic health, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015 by Blumberg JB1, Basu A2, Krueger CG3, Lila MA4, Neto CC5, Novotny JA6, Reed JD3, Rodriguez-Mateos A7, Toner CD. (PubMed)

Serum Levels of #Carotenoid Are Not Associated with the Risk of #SkinCancer, Researchers Say

Kyle J. Norton

The skin is a large outer layer organ of the human body that not only protects the internal tissues and organ against the invasion of foreign pathogens but also serve as the third detoxified organ after the liver and kidney.

Furthermore, the skin also plays an essential role in regulating body temperature and permits the sensations of touch, heat, and cold.

The skin contains 3 layers
* The epidermis, the outermost layer of skin.

* The dermis, beneath the epidermis.

* The deeper subcutaneous tissue (hypodermis).

Skin cancer is a medical condition caused by the uncontrolled growth of abnormal skin cells and often detected at an early stage.

According to the statistics, every year, approximately 4.3 million cases of basal cell cancer (BCC) are diagnosed in the U.S. compared to over 1 million cases of Squamous cell carcinoma (SCC) which is the second most common form of skin cancer.

There are three most common skin cancers, depending on the cancer cells originated
* Basal cell cancer (BCC)
Basal cell cancer is the most common type of skin cancer caused by abnormal growth of the cells in the lowest layer of the epidermis, accounting for more than 90% of all skin cancer in the U.S. Basal cell cancer rarely spreads and kills but can cause significant destruction and disfigurement to the affected skin area.

* Squamous cell cancer
Squamous cell cancer arises from the uncontrolled multiplication of transformed malignant cells in the middle layer of the epidermis.


*Melanoma
Melanoma, a kind of skin cancer but less common than other skin cancers is a result of malignancy of melanocytes, which produce dark pigment for your skin.

Epidemiologically, long-term exposure to sunlight, family history, age, gender, chemical exposure, exposure to radiation, smoking, and history of sunburns are some prevalent factors associated with the risk of the disease.


Carotenoids are a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomatoes, pumpkins, carrots, corn, and daffodils.

In concern to the overexpression of carotenoids enhancing the risk of skin cancer, researchers investigated the associations of several carotenoids and alpha-tocopherol with the risk of nonmelanoma skin cancer.

The study included serum carotenoids and alpha-tocopherol collected at baseline from 302 subjects who had at least two BCCs in the 5 years prior to randomization in the Isotretinoin-Basal Cell Carcinoma Prevention Trial.

During 5 years of follow-up, 70 subjects did not develop nonmelanoma skin cancer, 221 developed a BCC, and 85 developed a squamous cell carcinoma (SCC).

In chemical analysis, researchers found that* Serum levels of any of the carotenoids measured or to alpha-tocopherol are not associated with the risk of developing a subsequent BCC.

* Furthermore, serum levels of alpha-carotene, beta-carotene, lycopene, and alpha-tocopherol found in carotenoids also were not independently related to the risk of a subsequent SCC.

* However, serum lutein, zeaxanthin, and beta-cryptoxanthin were positively related to SCC risk with a risk ratio for subjects in the highest versus lowest tertiles of these micronutrients were 1.63.

In other words, overexpression of lutein, zeaxanthin, and beta-cryptoxanthin increased the risk SCC compared to no risk of carotenoids.

Based on the findings, researchers said, "Additional research is needed on the relationship of carotenoids to SCC risk in the general population and in subsets of the population who are at increased risk".

Taken together, dietary carotenoids do not increase the risk of skin cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Serum carotenoids and alpha-tocopherol and risk of nonmelanoma skin cancer by Dorgan JF1, Boakye NA, Fears TR, Schleicher RL, Helsel W, Anderson C, Robinson J, Guin JD, Lessin S, Ratnasinghe LD, Tangrea JA. (PubMed)
(2) Association of Vitamin A and Carotenoid Intake with Melanoma Risk in a Large Prospective Cohort by Maryam M. Asgari, MD MPH,1,2 Theodore M. Brasky, Ph.D.,3,4 and Emily White, Ph.D. (PMC)
(3) Skin Cancer (Excluding Melanoma) by Kyle J. Norton

#Herbal #Turmeric's #Curcumin Nanoformulations Inhobit Pathways and Receptors Associated with the Risk of #ColorectalCancer, According to Studies

Kyle J. Norton

The colorectum including the large intestine and the rectum is the second part of the digestive system involved in the absorption of water from the small bowel contents and the breaking down of certain materials in the feces into substances some of which are reabsorbed and reused by the body.
Colorectal cancer is a medical condition caused by irregular cell growth in the tissue of the colon or rectum.

Most cases of colorectal cancer start in the cells on the surface of the inner lining of the colon and rectum, before penetrating into deeper layers to form a tumor through proliferation.

Colorectal cancer is relatively very common and slowly growing and progresses cancer in a predictable way.

According to the statistics provided by the American Cancer Society, excluding skin cancers, colorectal cancer is the third most common cancer diagnosed in both men and women in the United States.

In 2019, approximately 101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in the US.


The 5-year survival rate of colorectal cancer diagnosed at the localized stage is 90%. Sadly, only 39% of patients are diagnosed at this early stage.

The exact causes of colorectal cancer are unknown. Epidemiologically, the most common risk factors associated with the onset of the disease are
* Age
The disease is more common in people over the age of 50. Regular colonoscopy after the age of 50 is valuable to detect the disease in the early stage.

* Bowl inflammatory diseases
A prolonged period of inflammatory diseases of the colon, such as ulcerative colitis and Crohn’s disease, can increase your risk of colon cancer due to long term inflammation of the lining of the colon.

* Family History of colorectal cancer
People with parents, siblings, children who have had colorectal cancer are more likely to develop colon cancer.

* Inherited Syndromes
Genetic syndromes passed through generations can increase the risk of developing colon cancer.

However, most people with some of the aforementioned prevalent factors have never developed colorectal cancer.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, etc.

With an aim to find a potential compound for the treatment of colorectal cancer, researchers investigated the effects of curcumin nanoformulations anti-cancer activity by overcoming the limitations of the compound.

Application of the nanoformulations not only displayed a greater anticancer activity compared to free curcumin but also extended at the same time non-toxic to the normal cells.

Furthermore, curcumin also demonstrated a strong colorectal cancer effect in the regulation of multiple cell signaling pathways associated with tumor growth and anti-apoptosis.

Moreover, curcumin also promoted the expression of tumor suppressor gene which is crucial in cancer development and progression.

The joint study led by the Ahvaz Jundishapur University of Medical Sciences in the examination of curcumin, a bioactive substance originating from turmeric root anticancer properties showed that curcumin inhibited the expression of a gene associated with involved in tumor initiation and progression. In other words, through inhibition of this gene, curcumin reduced the risk of tumor metastasis.

Additionally, by inhibiting the insulin and insulin-like growth factor-1 receptor curcumin showed a greater decrease in the proliferation and migration of chemoresistant colorectal cancer cells.

Based on the results, Dr. Hosseini SA, the lead scientist said, "These results suggest the possible therapeutic effects of curcumin in adjuvant therapy in metastatic colorectal cancer".

Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of colorectal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A Possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells by Hosseini SA1, Zand H2, Cheraghpour M. (PubMed)
(2) Curcumin Nanoformulations for Colorectal Cancer: A Review by Wong KE1,2, Ngai SC3, Chan KG4,5, Lee LH1,2,6, Goh BH1,2,6, Chuah LH. (PubMed)
(3) Bowel (Colorectal ) Cancer by Kyle J. Norton

#Brassica rapa Inhibits Liver Oxidativestress Markers and Pathways Associated with the Onset of #Liverdieases, Researchers Find

Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by the reduction of partly or completely the function of the liver, including liver failure.

The most common types of liver disease in the US are
* Hepatitis C (26%) is a liver disease caused by liver inflammation caused by viral Hepatitis C, leading to irreversible liver scars. Over time, the condition can also induce liver cancer.

* Alcoholic liver disease (21%) is a condition that caused long-term excessive alcohol drinking. It is known that years of alcohol abuse can cause the liver to become inflamed and swollen. Over time, it has been found to induce the formation of liver scars, known as cirrhosis. Cirrhosis is the final stage of liver disease.

* Hepatitis C plus alcoholic liver disease (15%).

* Cryptogenic causes (18%) is a condition with no apparent underlying reason. However, most researchers suggested that many cases of cryptogenic cirrhosis are likely caused by non-alcoholic fatty liver disease (NAFLD), a condition of fat accumulated in the liver.

* Hepatitis B and D (15%) are liver diseases caused by liver inflammation caused by viral Hepatitis C, leading to irreversible liver scars. Over time, the condition can also induce liver cancer.


Human toxicity is a general term that refers to any substance which causes harm to human health if inhaled, ingested, or absorbed through the skin.

Liver toxicity is a process that causes liver damage by reducing the function of the liver.

Liver oxidative stress caused by a toxic substance such as an overdose of the supplement has been found to constitute most cases of acute liver damage.

Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of liver diseases, researchers examined the hepatoprotective effects of B. Rapa polysaccharides (BRPs) on acute liver injury induced by carbon tetrachloride (CCl4 ) in mice.

According to the results of Mice treated with CCl4 after the oral administration of BRPs (55, 110, and 220 mg/kg) or bifendate (100 mg/kg) for 7 days,

* BRP pre-treatment significantly decreased the enzymatic activities of liver oxidative stress markers ALT, ALP, and AST in the serum, by increasing the activities of antioxidant enzymes SOD and GSH-Px in the liver and reduced the MDA concentration in the liver.

* BRPs alleviated hepatocyte injury and markedly inhibited the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6.

* Furthermore, BRPs downregulated the CCl4 -induced hepatic tissue expression of caspase-3 involved in cell apoptosis.

* Moreover, BRPs inhibited the JAK2/STAT3 signaling pathway associated with the inhibition of cell division and stimulation of inflammation in a dose-dependent manner in the liver.


Based on the results, researchers wrote, " BRPs exert hepatoprotective effect against the CCl4 -induced liver injury via modulating the apoptotic and inflammatory responses and downregulating the JAK2/STAT3 signaling pathway".

Taken together, Brassica rapa may be considered supplementation for the prevention of acute liver damage, pending the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Brassica rapa Polysaccharides Ameliorate CCl4 -Induced Acute Liver Injury in Mice through Inhibiting Inflammatory Apoptotic Response and Oxidative Stress by Li Q1, Yang H1, Wang W2, Li N1, Zou X1, Li Y2, Fan G1, Zhang Y1,2, Kuang T. (PubMed)