#MonofloralHoney Process Anti- Human immunodeficiency Virus HIV-1 Through Inhibiting Effect of Methylglyoxal, Researchers Say

Kyle J. Norton

Honey may have a profound effect in reducing the risk and treatment of HIV-1, some scientists suggested.
Human immunodeficiency virus HIV-1 is the most widespread type worldwide that can lead to acquired immunodeficiency syndrome (AIDS).

Acquired immunodeficiency syndrome (AIDS) is a chronic condition caused by the infection of the human immunodeficiency virus (HIV).

According to epidemiological studies, people who serval sexual partners are the most at risk of HIV infection.

However, the virus can also be transmitted through infected blood transfusion, and infected mother to children.

Most people infected by the HIV virus may experience symptoms of fever, muscle aches, and joint pain similar to those of influenza in the early stage of the viral attacks.


At the final stage of the infection, the virus can weaken the immune system to the point that causes the onset of AIDS and induces more severe symptoms including the general symptoms of cancers accompanied by soaking night sweats, recurring fever, and persistent white spots or unusual lesions on your tongue or in your mouth.

Dr. Seth C Kalichman and colleagues in the infectious team, concerned about the risk of HIV in people with multiple sexual partners in the examining the 209 HIV-positive men and 291 HIV-positive women recruited conveniently from HIV/AIDS support groups and antiretroviral clinics found that 63% and 309 (62%) participants were currently sexually active, of whom 247 (80%) reported only one sex partner in the previous 3 months and 62 (20%) reported two or more partners during that time".


Although the use of a condom may have some protective effects in the prevention of HIV transmitting disease, however, the team said, "Steady sex partners of participants with multiple partnerships were significantly less likely to be protected by condoms than steady partners of individuals with only one sex partner".


Dangerously, in the final report, the team wrote, "Individuals with multiple sex partners were also significantly less likely to have disclosed their HIV status".

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.

In finding a natural ingredient or whole food for the inhibition of human immunodeficiency virus HIV-1 before they can cause acquired immunodeficiency syndrome (AIDS), researchers evaluated the anti-HIV-1 activity of eight different kinds of honey.

The tested Monofloral Iranian honey from eight floral sources was analyzed to determine their anti-HIV-1 activities as well as their effects on lymphocyte proliferation.

According to the quantitative polymerase chain reaction (PCR) assay and high pure viral nucleic acid kit, 6 out of 8 monofloral kinds of honey from Petro selinum sativum, Nigella sativa, Citrus sinensis, Zataria multiflora, Citrus aurantium, and Zizyphus mauritiana flowers exerted a significantly inhibitory HIV-1 activity at different doses.

The half-maximal effective concentration (EC50) values of 6 out of 8 monofloral kinds of honey are 37.5, 88, 70, 88, 105, and 5 µg/ml respectively.

The monofloral Iranian kinds of honey from Astragalus gummier and Chamaemelum Nobile flowers had a weak anti-HIV-1 activity, compared to others.

The frequency and intensity of cluster of differentiation CD4 expression on Peripheral blood mononuclear cells (PBMC) increased in the presence of all honey types, an indication of immune activity.

Peripheral blood mononuclear cells (PBMC) are round nucleus peripheral blood cells consisting of lymphocytes (T cells, B cells, NK cells), and CD4 cells or T4 helpers play critical roles to send signals to other types of immune cells with a function to destroy invasive pathogens.

Treatment with monofloral kinds of honey from Z. multiflora and N. Sativa also increased the CD19 markers for normal and neoplastic B cells.

According to the spectroscopic analysis, monofloral kinds of honey from P. sativum, N. sativa, Z. multiflora, and Z. mauritiana flowers processed a potency to be anti-HIV-1 agents.

In in-depth differentiation, researchers showed that the inhibitory effect of methylglyoxal is higher in the late stage of HIV-1 infection.


The chemical compound found to exert anti-HIV-1 activity was methylglyoxal.

Taken together, monofloral kinds of honey containing high amounts bioactive compound methylglyoxal may be considered a functional food for the prevention of HIV-1 infection and combined with the primary therapy for the treatment of AIDs.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Anti-HIV-1 activity of eight monofloral Iranian honey types by Behbahani M1. (PubMed)
(2) Recent multiple sexual partners and HIV transmission risks among people living with HIV/AIDS in Botswana by Seth C Kalichman, Dolly Ntseane, Keitseope Nthomang, Mosarwa Segwabe, Odireleng Phorano, and Leickness C Simbayi. (PMC)

#Herbal #Angelica Sinensis (RAS) Supplementation Inhibits Gene Expression Associated with an Increased Weight Loss in Obesity, Researchers Find

Kyle J. Norton

Obesity is a medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.
The most common causes of obesity are associated with
* An increased intake of energy-dense foods that are high in saturated and trans fat, processed foods, and red meat.

* An increase in physical inactivity.

That leads to the accumulation of visceral fat in the body

Visceral fat in obesity is associated with 90% of patients with ischemic heart disease. In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.

Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.

However, in non-obese subjects, visceral fat accumulation is correlated with glucose intolerance, hyperlipidemia, and hypertension.

Obesity rates have increased for all age groups in the US over the last several decades, coincidently with the periods that promoted the Western diet.

The WHO in the explanation of the causes of obesity wrote, "Changes in dietary and physical activity patterns are often the result of environmental and societal changes associated with the development and lack of supportive policies in sectors such as health, agriculture, transport, urban planning, environment, food processing, distribution, marketing, and education".

Certain medical conditions such as hypothyroidism, polycystic ovary syndrome, Cushing's syndrome,..., genetic preposition, and use of certain medications that can cause weight gain or water retention, such as corticosteroids, antidepressants or some seizure medications, also increase the risk of overweight and obesity.

In finding a natural ingredient for the prevention of overweight, scientists examined the root of Angelica sinensis (RAS) supplementation effects on FTO gene expression and methylation status in body weight on an animal model,

Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to tested analysis, high-fat-diet (HFD) induced obese female mouse that was divided into groups according to RAS dosage in the diet as follows: normal diet, HFD diet (HC), HFD with low-dosage RAS (DL), HFD with medium-dosage RAS (DM), and HFD with high-dosage RAS (DH). After RAS supplementation for 4 weeks,
* Bodyweight suppression and FTO expression associated with reduced weight in DH mice were significantly higher compared to HC mice and no significant change in FTO expression was detected between DM and DL mice or in their offspring.

* Furthermore, CpG island (the regions with a high frequency of CpG sites) in the FTO promoter was hypermethylated up to 95.44% in the HC group, 91.67% in the DH group, and 90.00% in the normal diet group.

* Most importantly, the adipocyte expression in the DH group was smaller than those in the HC group.


These results strongly suggested that RAS may have a potential role in the inhibition of obesity.

Based on the results, researchers suggest, that "RAS could ameliorate obesity induced by HFD and that the molecular mechanism might be associated with the expression of the FTO gene".

Taken altogether, Dandelion may be considered a remedy for the treatment of obesity, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica sinensis Suppresses Body Weight Gain and Alters Expression of the FTO Gene in High-Fat-Diet Induced Obese Mice by Zhong T1, Duan XY1, Zhang H1, Li L1, Zhang HP1, Niu L. (PubMed).

#CruciferousVegetables Inhibit the Risk of #HeartAttack on Glutathione S-Transferases (GSTs) Against #CoronaryHeartDisease, Researchers Say

Kyle J. Norton

Stroke is the third leading cause of death. Approximately 1/4 of all stroke victims die as a direct result of the stroke or its complications.

Stroke is caused by the accumulation of cholesterol and other substances that build up the arterial walls. In other words, if cholesterol building up in the arteries is blocking the circulation of blood in any part of the body causing oxygen not to be delivered to the brain, leading to the death of some cells in the brain.

According to the statistics, every year, more than 790,000 people suffer a stroke, including 600,000 of these are first attacks, and 185,000 are recurrent attacks. Most cases of stroke occur in people over the age of 65.

Myocardial infarction is a severe medical emergency characterized by the obstruction of the blood supply to the brain, causing local brain neurons to die. Prompt treatment can minimize brain damage and potential post-disease complications.

The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.

In other words, brain infarction can be classified into myocardial infarction due to plaque rupture and myocardial oxygen supply-demand imbalance secondary to other acute illnesses.


Depending on the severity of the acute infarction, in serious cases, patients may also experience symptoms, paralysis of the face, arm, or leg, and trouble with seeing in one or both eyes.

Although, there are many factors associated with the risk of acute infarction. some researchers suggested an unhealthy diet may have a strong and negative implication on the onset of the condition.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, and species, and cultivated all over the world in suitable climates for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.


In finding a potential remedy for the management of post-stroke, researchers examined the association between cruciferous vegetable intake and the risk of myocardial infarction (MI) on glutathione S-transferases (GSTs) against coronary heart disease.


The study included a total of 2042 patients with a first acute nonfatal MI and population-based controls (n = 2042) living in Costa Rica, the area of residence, were genotyped for a deletion polymorphism in GSTM1 and GSTT1 and an Ile105Val substitution in GSTP1.


According to the food questionnaire returned
* Compared with the lowest tertile of cruciferous vegetable intake, the highest tertile was associated with a lower risk of MI among persons with the functional GSTT1*1 allele (OR: 0.70; 95% CI: 0.58, 0.84) but not among those with the GSTT1*0*0 genotype (OR: 1.23; 95% CI: 0.83, 1.82) (P = 0.006 for interaction).
* Furthermore, the protective effect of cruciferous vegetable intake among those with the GSTT1*1 allele was greater for current smokers (OR: 0.54; 95% CI: 0.36, 0.79) than for nonsmokers.


* More importantly, GSTP1 and GSTM1 did not modify the association between cruciferous vegetable intake and MI.

Based on the results, researchers said, "Consumption of cruciferous vegetables was associated with a lower risk of MI among those with a functional GSTT1*1 allele, which suggests that compounds that are detoxified by this enzyme contribute to the risk of MI.".

Taken altogether, cruciferous vegetables may be considered functional remedies for the management of myocardial infarction in patients with the GSTT1*1 allele, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight


How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How to Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) GSTT1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction by Cornelis MC1, El-Sohemy A, Campos H. (PubMed)

#Phytochemical #Sulforaphane Inhibits #CervicalCancer through Its Anti-Proliferative, Cytotoxic and Apoptotic Activities According to Studies

Kyle J. Norton

Scientists may have found a bioactive compound isolated from cruciferous vegetables for the prevention and treatment of cervical cancer with no side effects, according to studies.

The cervix is an opening passage in the center of the ectocervix, that connects the uterus to the vagina in female reproductive organs. The cervix acts as a transition area for the vaginal lining (squamous epithelium) to change to the uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.

Cervical cancer is a medical condition caused by irregular and disordered cell growth in the tissue of the cervix.

Most cases of cervical cancer start in the cells on the surface of the inner lining of the cervix. At the early stage, most patients do not experience any symptoms.


However, at the later stage, the overgrowth tumor may suppress the nearby blood vessels and nerve tissue, leading to abnormal bleeding and severe abdominal pain.

At this stage, cancerous cells from the cervix also can travel a distance away to infect other healthy tissue and organ, through lymph and blood circulation, causing secondary metastasis.

Most common cervical metastasis includes the vagina, the uterus, the uterus, tissue nearby lymph nodes in the pelvis, the back of the abdomen tissue, and ligaments around the cervix and uterus

According to the statistic, cervical cancer is most often diagnosed between the ages of 35 and 44 and only 15% of cervical cancers are diagnosed in women over age 65.

The five-year survival rate of invasive cervical cancer is 92% if diagnosed in the early stages.

What causes cervical cells' DNA alternation? Researchers do not know. However, researchers do know that immune system deficiency, smoking, the increase in age, long-term use of oral contraceptives, and exposure to diethylstilbestrol are some of the prevalent risk factors associated with the onset of the disease.

Some researchers also suggested women who have several sexual partners or often change sexual partners are at increased risk of being infected by the Human papillomavirus (HPV), one of the major causes of cervical cancer.

Dr. Diane Cooper, the lead scientist in cancer research in the examination the sexual activity in the risk of cervical cancer among South African women wrote, "cervical cancer risk is associated with increased sexual activity. Initiatives to encourage later commencement of sex, and limiting the number of sexual partners would have a favorable impact on the risk of cancer of the cervix and other sexually transmitted infections".

These results clearly suggested that women who are sexually active and have a number of sexual partners should take extreme precautions to protect themselves against HPV infection.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

In finding natural chemoprevention that holds great potential for cancer management as lower, clinically tolerable doses of individual agents for the treatment of cervical cancer, the cancer team at the Manipal University examined the effect of combination treatment of sulforaphane (SFN) and eugenol on HeLa cells.

Injection with variable dose combinations of SFN and eugenol showed a significant effect in inducing cell cytotoxicity and apoptosis at the lower and synergistic effect at higher sub-lethal doses to the cancer cells.

Furthermore, the application of chemo drugs gemcitabine combined with the low- and high-dose SFN combinations showed no significant cell death at lower doses compared to that of cell cytotoxicity in gemcitabine alone.

These results clearly suggested that SFN can only elevate the efficiency and lower the dose of certain chemo drugs which act on certain pathways in inducing cytotoxicity and cell death with decreasing side effects.

Additional examination of the effect of SFN and eugenol combinations researchers found that SFN significantly inhibits the expression of the proteins associated with cell proliferation and the production of inflammatory cytokines.

Dr. Hussain A, the lead scientist in the final report wrote, "2 (or more) chemopreventive agents can act antagonistically or synergistically necessitating elucidation of possible mechanistic interactions for favorable and reliable outcomes of dietary components in the field of cancer prevention".

Compared to chemo drugs, injection of sulforaphane alone exerted a strong effect in inducing dose-dependent selective cytotoxicity in HeLa cells without causing harm to the normal cells.

The finding emphasized that the bioactive compound processes a safe cytotoxicity profile compared to conventional chemomedicine.

Also, sulforaphane alone was found to express its efficacy through analysis of genes similar to that of SFN and eugenol combination.

In human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells, SFN inhibited the viability of both HeLa and HepG2 cells by inducing apoptosis, observed by the formation of apoptotic bodies and the accumulation of the sub-G1 phase.

In in-depth differentiation of SFN activity, researchers discovered that SFN not only induces cell death through the cancer cell cycle arrest but also activates the genes associated with the programming cell death and cell apoptosis by blocking the expression of cell proliferative proteins.

Taken altogether, sulforaphane SFN may be considered chemo and natural medicine for the prevention and combined with certain primary medicines for the treatment of cervical cancer with a reduced side effect through lowering the dose of the applied chemo drug.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Concurrent sulforaphane and eugenol induce differential effects on human cervical cancer cells by Hussain A1, Priyani A, Sadrieh L, Brahmbhatt K, Ahmed M, Sharma C.(PubMed)
(2) Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells by Sharma C1, Sadrieh L, Priyani A, Ahmed M, Hassan AH, Hussain A.(PubNed)
(3) Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3 by Park SY1, Kim GY, Bae SJ, Yoo YH, Choi YH.(PubMed)
(4) Determinants of sexual activity and its relation to cervical cancer risk among South African Women by Diane Cooper,1 Margaret Hoffman,1 Henri Carrara,1 Lynn Rosenberg,2 Judy Kelly,2Ilse Stander,3 Lynnette Denny,4 Anna-Lise Williamson,5,6 and Samuel Shapiro. (PMC)

#Protein Stem Bromelain (SBM) Inhibits Genes and Proteins Associated with the Onset of Obesity and #ObeseComplications, Researchers Find

Kyle J. Norton

Obesity is a chronic medical condition associated with excessive fat accumulation over time.
According to the BMI index, a person is considered overweight, if he/she has a BMI between 25 to 29.9 kg/m2. A BMI of 30 kg/m2 or more is an indication of obesity.

In other words, obesity is a progressive chronic disease characterized by abnormal fat accumulation in the body tissues that may impair health.


Similar to other chronic medical conditions including diabetes, cardiovascular disease, or high blood pressure, obesity has recently become a serious health problem in the US as nearly 35% of Americans are obese accompanied by a similar percentage of overweight adults.


Epidemiologically, obesity does not only have serious effects on physical and psychological health but also has a strongly negative impact on the patient's quality of life.

Today, the widespread obesity in the U.S. population has caused a significant economic impact on the U.S. healthcare system, including direct and indirect costs.


The Milken Institute wrote, "The burden of obesity, and the chronic diseases for which it is a contributing factor, has reached record economic heights. In 2016, chronic diseases driven by the risk factor of obesity and overweight accounted for $480.7 billion in direct healthcare costs in the U.S., with an additional $1.24 trillion in indirect costs due to lost economic productivity. The total cost of chronic diseases due to obesity and overweight was $1.72 trillion — equivalent to 9.3 percent of the U.S. gross domestic product (GDP). Obesity as a risk factor is by far the greatest contributor to the burden of chronic diseases in the U.S., accounting for 47.1 percent of the total cost of chronic diseases nationwide".


Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

In the concern of the rise of obesity incidence in the world, researchers examined the phytotherapeutic protein stem bromelain (SBM) anti-obesity activity.

At the cellular levels, SBM irreversibly inhibited 3T3-L1 adipocyte differentiation in the expression of the obese gene product (leptin) in white adipose and induced apoptosis and lipolysis in mature adipocytes.

At the molecular level, SBM suppressed adipogenesis by inhibiting gene expression of PPARγ in developing obesity.

Furthermore, SBM also reduced the secretion of adipocyte fatty acid-binding protein (ap2) associated with obese glucose and lipid metabolism, and fatty acid synthase (FAS) involved in food intake and body weight.

Lipoprotein lipase (LPL) which leads to increased lipid partitioning to other tissues, insulin resistance, and obesity, and gene CD36 CD36 associated with a number of metabolic pathways with relevance to obesity and enzyme acetyl-CoA carboxylase (ACC) involved in the biosynthesis and metabolism of fatty acids also inhibited by the injection of SBM.

Moreover, SBM was found to augment the expression of TNFα(tumor necrosis factor-alpha) -induced lipolysis and apoptosis in mature adipocytes, another indication of anti-obesity properties.

Where TNFα(tumor necrosis factor-alpha) has been proposed as a link between obesity and insulin resistance.

The results strongly supported the use of SBM for the prevention of obesity in an animal model.


Additionally, according to a study led by the University of British Columbia, bromelain from papaya and pineapple may be used to control obesity and obesity complications such as hypertension, and diabetes.


Taken together, bromelain used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of neurodegeneration, pending the confirmation of the larger sample size and multicenter human study.


Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of adipogenesis and induction of apoptosis and lipolysis by stem bromelain in 3T3-L1 adipocytes by Dave S1, Kaur NJ, Nanduri R, Dkhar HK, Kumar A, Gupta P. (PubMed)
(2) Plant proteases for bioactive peptides release A review by Mazorra-Manzano MA1, Ramírez-Suarez JC2, Yada RY. (PubMed)
(3) The economic burden of obesity and diabetes by November 6, 2018, by Jennifer Calihan. (Diet Doctor)

#Tussilagonone (TGN) Found in #Herbal #Coltsfoot Promotes #SkinHealth Through Its Antioxidant Activity, Scientists Suggest

Kyle J. Norton

Skin, a large external organ in the human body is the outer layer, with a total area of about 20 square feet which protects the internal organs, bones, and tissues against damage.
The skin processes 3 main layers
* The epidermis is the outermost layer of the skin providing a barrier against infection from environmental pathogens. The outer layers also regulate the amount of water released from the body through transepidermal water loss.

* Dermis is the second layer of skin, containing blood capillaries, nerve endings, sweat glands, hair follicles, and other structures.

* The bottom layer is the subcutaneous fat which has been found to process the protective effect against the dangers of visceral fat.

Skin inflammation is a condition that occurs when your immune system responds to a stimulus or triggers inflammation on the skin.
Inflammation is a natural process of the immune system that tries to protect our body against the invasion of stimuli and pathogens.

This process has been found to involve several stages after the bodily injury caused by physical impact or internal damage.

In the acute phase of infection, the white blood cells of the first line of immune defense stimulate the production of blood coagulation to cover the wound and activate the protein associated with the production of inflammatory cytokines to kill off the invaders before they can enter the body.

However, overproduction of proinflammatory cytokines can lead to damage and death of the healthy cells, causing irreversible scars as in liver hepatitis infection.

Chronic inflammation (CI) is a result in which the immune system can not destroy the invasive pathogens in the acute phase of infection within 3- 8 weeks, leading to the immune adaptation of the new change in facilitating low-grade inflammatory diseases, including arthritis and diabetes.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used for thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches obstruction in the nasal passage, etc.

In finding a potential compound for the treatment of skin disease, researchers examined the effect of tussilagonone (TGN), a sesquiterpene compound isolated from T. farfara's anti-inflammatory activity.

In RAW 264.7 cells, based on the tested analysis, administration of TGN enhanced the HO-1 expression associated with reducing inflammatory stress, oxidative stress, and ER stress and nuclear factor-E2-related factor 2 (Nrf2), associated with the antioxidant defense in a time- and dose-dependent manner.

Furthermore, TGN also suppressed the proteins associated with the production of proinflammatory cytokines such as nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) by reducing the mRNA expression of proinflammatory cytokines.


In vivo, TGN also reduced iNOS and COX-2 expression in a mouse model of skin inflammation induced by the injection of 12-O-tetradecanoylphorbol-13-acetate (TPA).

Based on the findings, researchers said, "These findings suggest an important role for TGN-induced HO-1 activation in regulating inflammatory responses.".

Taken together, coltsfoot may be considered a remedy for the improvement of skin conditions caused by inflammation, pending the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Heme oxygenase-1-mediated anti-inflammatory effects of tussilagonone on macrophages and 12-O-tetradecanoylphorbol-13-acetate-induced skininflammation in mice by Lee J1, Kang U2, Seo EK2, Kim YS. (PubMed)

#Herbal #Trmeric Reduces Crohn's disease Symptoms and Inhibits Parameters Associated with an Increased Risk of #ColorectalCancer, Scientists Say, Studies Show

Kyle J. Norton

Crohn's disease is a type of inflammatory bowel disease caused by inflammation in the gastrointestinal tract.
The exact cause of Crohn's disease is not identified. However, some researchers suggested that people with a compromised immune system and genetic preposition are prone to the disease onset compared to people who do not

The most common symptoms of Crohn's disease are abdominal pain, severe diarrhea, fatigue, weight loss, and malnutrition.

If you are experiencing symptoms of severe abdominal pain accompanied by blood in the stool and persistent diarrhea, please check with your doctor right away.


Risk factors of Crohn's disease include aging, family and personal history, ethnicity, smoking, and long-term use of Nonsteroidal anti-inflammatory medications.
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Out of many risk factors that cause the onset of the condition, some researchers suggested that your risk of Crohn's disease depends on where you live.

Dr. Pascal Michel wrote, "Crohn's disease (CD) is clinically expressed as a chronic affection of the gastrointestinal tract currently known to have a multifactorial etiology involving a complex pathophysiological host response modulated by genetic susceptibilities, demographic determinants, and environmental factors. With more than 20 cases per 100,000 person-years, the province of Quebec, Canada is among regions of the world with the highest reported occurrence of CD in relation to other places where comparable estimates are available".


And, "These findings suggest that known populational and regional factors derived through census information only explain a limited fraction of the geographical variation of CD incidence and lead to speculate that the effects of these factors may be incompletely captured (imperfect construction of proxy variables) or that other important factors remain unmeasured".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

In finding a natural ingredient for the treatment of Crohn's disease (CD), researchers at the Grand Valley State University compared the effects of Remicade to curcumin for the treatment of the condition.

The review study includes a search in electronic databases (ProQuest Medical Library, CINAHL Complete, and PUBMED) to locate and identify articles to meet a predetermined set of inclusion criteria, including articles published after 2007 in human participants 18 years or older.


Compared to Remicade in reducing TNF-a, the protein associated with inflammation in adults with CD, curcumin induced a 55 points mean reduction in the Crohn's Disease Activity Index, reduced the expression of IL-1 and levels of C-reactive protein (CRP), associated with elevated levels of proinflammatory cytokines in the colon, particularly in the reduced levels of TNF-a and PPMTase involved in the improvement of colorectal cancer outcomes.

Based on the findings, researchers said, "...Preliminary data would suggest using both would reduce LOR. Curcumin, even by itself, was found to be a cheap and safe way to reduce CD symptoms and inflammatory markers"


Furthermore, according to the study conducted by the Medical School of Marília in the search for articles associating curcuminoids and CD and UC on the database of MEDLINE-PubMed, curcumin demonstrated an intestinal protective effect on reducing oxidative stress and inhibiting the migration of neutrophils and inducible nitric oxide synthase in the intestine.

Moreover, curcumin also improved micro and macroscopic lesions in the gut, prevented apoptosis of intestinal cells, and induced the restoration of immune reaction.

Dr. Cunha Neto F, after taking into account co and confounders wrote, "The use of curcumin is cheap, efficient and associated with no side effects, and may become an alternative to the IBD treatment".

Taken altogether, turmeric processed with a high amount of bioactive compound curcumin may be considered as upplement for the prevention and treatment of Crohn's disease (CD), pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Comparison of remicade to curcumin for the treatment of Crohn's disease: A systematic review by Schneider A1, Hossain I1, VanderMolen J2, Nicol K. (PubMed)
(2) Curcuminoids from Curcuma Longa: New adjuvants for the treatment of Crohn's disease and ulcerative colitis? by Cunha Neto F1, Marton LT1, de Marqui SV1, Lima TA1, Barbalho SM. (PubMed)
(3) Geographical variation of Crohn's disease residual incidence in the Province of Quebec, Canada by Pascal Michel,1,2 Laurie St-Onge,1 Anne-Marie Lowe,3 Michel Bigras-Poulin,2 and Paul Brassard. (PMC)