#Cranberry Powders, a Potential Hyperglycemia Management Agent Against Diabetics Complications

Kyle J. Norton


Diabetes is a medical and chronic disease characterized by insufficient insulin entering the bloodstream to regulate glucose.

The disease is either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol, such as type 2 diabetes.

Most cases of type 1 diabetes are associated with a gene mutation that causes the immune to attack the insulin-producing beta cells in the pancreas.

Acquired diabetes in most cases is caused by unhealthy lifestyle choices, including a high-fat diet and physical inactivity.

According to the statistics provided by the CDC, approximately 23.1 million people in the United States are living with diagnosed diabetes, costing the healthcare system more than $245 billion per year.

Sadly, there is an estimation that another 7.2 million people have diabetes but remain undiagnosed, accompanied by another 84.1 million adults 18 years and older with prediabetes.

Hyperglycemia, a hallmark of diabetes is a condition of abnormally high blood glucose in the blood.

Most cases of hyperglycemia are a result of poor management of blood glucose including uncontrolled diet, physical inactivity, miss-medication, and improper use of insulin injection.

Uncontrolled diabetes or hyperglycemia over the long term can lead to diabetic complications, including coronary heart disease, stroke, hypertension, depression, pain, polypharmacy, and functional disability.

Long-term elevated glucose values above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11 millimoles per liter (mmol/L) have been found to induce symptoms of frequent urination, increased thirst, blurred vision, fatigue, and headache.

In severe cases, some patients may also experience life-threatening complications such as fruity-smelling breath, shortness of breath, weakness, confusion, and coma.

Dr in the study of hyperglycemia in the aging population wrote, "Higher levels of Sirt1 and PGC-1α and increased expression of gluconeogenesis pathway genes are found in the hyperglycemic NOD mice. Increased Sirt6 abundance is found in the hyperglycemic NOD mice, which might increase DNA damage repair".

And, "With aging, lower Sirt1 abundance and activity increased acetylated histone modifications and Sirt7 levels, and NOR methylation is found. Thus, whereas in normal aging cell metabolism is reduced, in the diabetic mice a compensatory mechanism may elevate Sirt1 and Sirt6 levels, increasing gluconeogenesis and DNA repair from the oxidative damage caused by hyperglycemia".

The onion is a plant in the genus Allium, belonging to the family Alliaceae, closely related to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of diabetes complications, researchers examined the effect of aqueous solutions of two different cranberry powders (CP and CP-SAB) on hyperglycemia.

In vitro, in vitro CP and CP-SAB administration showed a significant inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) associated with the management of hyperglycemia linked to type 2 diabetes.


Low levels of α-amylase have been found in patients with diabetes.

α-glucosidase is associated with the digestion of carbohydrates and is elevated in patients with diabetes

According to the chemical analysis, the efficacy of CP and CP-SAB that inhibits hyperglycemia was probably attributed to the chemical constituents p-Coumaric acid and quercetin derivatives, the main phenolic compounds identified in the cranberry powders.


Furthermore, increased with increased doses (1-5 mg/mL) of CP-SAB exerted the increased α-glucosidase inhibitory activity from 60% to 100%.

At 5 mg/mL, CP-SAB exerted a maximum of 40% inhibition against α-amylase.

Levels of ACE were also significantly inhibited by CP-SAB at the concentration of 100 and 200 mg/mL sample concentrations.

Based on the results, researchers wrote, "These in vitro results indicate the potential of cranberry powders as a dietary supplement and food-based strategies for potential hyperglycemia management".

Taken altogether, cranberry may be considered a remedy for the management of hyperglycemia, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Potential of cranberry powder for management of hyperglycemia using in vitro models by Pinto Mda S1, Ghaedian R, Shinde R, Shetty K. (PubMed)
(2) Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes by Flávia Gerelli Ghiraldini,1 Ana Carolina Vitolo Crispim, and Maria Luiza Silveira Mello. (PMC)

#Herbal #Angelica Inhibits Pathways and Pro-Inflammatory Cyrokines Induced-OxidativeInjury, According to Studies

Kyle J. Norton

The expression of oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.

In some cases, this reaction also causes the long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, oxidative burst from activated macrophages, particularly, the free radicals chain reaction.

Sadly, a prolonged period of oxidative stress present in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibit the onset of free radicals before they can cause a chain reaction in facilitating protein, lipid, and cell damage.

Apoptosis refers to the death of cells which occurs as a normal and controlled part of an organism's growth or development associated with the limited cycle division.

Anti-apoptotic activity found in cancer is associated with the proliferation and unlimited cell cycle division for the growth of cancer.

Chemo drugs used for the treatment of cancer can also cause cancer cell death by inducing toxicity. However, the treatment also leads to the death of healthy cells and weakened immune functioning.


Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

In finding a natural compound for the treatment of malignant tumors, the researchers examined the effects of Angelica Sinensis' polysaccharide (ASP) anti-apoptotic activity.

Based on the experimental differentiation, IN H9c2 cell, treated with hydrogen peroxide (H2O2), A. Sinensis exerted protective effects against oxidative injury through its various active ingredients on the regulation of multiple pathways associated with pro-inflammatory cytokines induced by oxidative stress.

Furthermore, ASP pretreatment significantly decreased H2O2-induced cytotoxicity and apoptosis in H9c2 cells.

Moreover, H2O2-induced oxidative stress observed by the expression of oxidative stress and ER stress markers such as malondialdehyde production and lactic dehydrogenase release was also inhibited by the antioxidant activity of ASP.


Collectively, researchers said, " Conclusions Our findings indicate that ASP, a major water-soluble component of A. Sinensis, exerts protective effects against H2O2-induced injury in H9c2 cells by activating the ATF6 pathway, thus ameliorating ER and oxidative stress".


Taken altogether, Herbal Angelica may be considered a remedy that protects the cell against oxidative stress, pending to larger sample size and multicenter human study.

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway by Niu X1, Zhang J2, Ling C3, Bai M4,5, Peng Y4,5, Sun S6, Li Y6, Zhang Z. (PubMed)
(2) Apoptosis in cancer: from pathogenesis to treatment by Rebecca SY Wong. (PMC)

#Ligustilide (LIG) Found in #Angelica Improves all Paraneters Associated with D-gal-Induced Cognitive Dysfunction and Brain Toxicity, Researchers Say

Kyle J. Norton

A neuroprotective effect is an event that protects the central nervous system (CNS) by relatively preserving the neuronal structure and/or function.

Neurological diseases are the medical conditions of CNS disorders. Anything that involves structural, biochemical, or electrical abnormalities in the brain, spinal cord, or other nerves, including brain damage is considered as neuro disease.

The most common neurodegenerative diseases in the elderly are dementia. Depending on the brain regions that are damaged or dysfunctional, dementia can be Parkinson's, Alzheimer's, and Huntington's disease.

There are many risk factors involved in the incidence of neurological disorders, including unhealthy lifestyle, infections, genetic preposition, and physical injury.

Genetic mutation inherited from parents such as the NOTCH3 gene is the most common autosomal dominant inherited that causes stroke and vascular dementia.

Oxidative stress is a result of an imbalance of the ratio of levels of free radicals and antioxidants caused either by overexpression of free radicals depletion of antioxidant enzymes or both.

Free radicals can be produced internally by normal cellular metabolism or from external sources such as the air we breathe, and smoking. Free radicals are unstable molecules with unpaired electrons on the outer ring.

In order for them to maintain stability, free radicals must either donate an electron or intercept an electron from other atoms, leading to a chain reaction that can not be stopped until the outer ring electron is paired or inhibited by antioxidants.

Oxidative stress has been found to be a major risk for the onset of neurological disorders in the Western world, particularly in North America.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

In finding a natural compound for the treatment of neurological diseases, the researchers examined the effects of Ligustilide (LIG) a principal active ingredient of Radix Angelica Sinensis on neuroprotective activity/

The aging model mice induced by subcutaneous (S.C.) injection of d-gal once daily for 8 weeks followed by LIG (80 mg/kg) were simultaneously administered orally.

Based on the experimental results,* LIG administration markedly improved the behavioral performance of d-gal-treated mice.

* LIG reduced the level of neuron stress markers MDA and increased the activity of Na(+)-K(+)-ATPase in the promotion of neurophysiology in the brain of d-gal-induced aging mice.


* Moreover, LIG significantly raised the expression of GAP-43 associated with the development and axonal regeneration and reduced cleaved caspase-3 to promote cell death and GFAP levels in brain injury in the brain of d-gal-treated mice.

Collectively, researchers said, "These results demonstrated that LIG improves d-gal-induced cognitive dysfunction and brain toxicity, which suggests that LIG may be developed as a new medicine for the treatment of age-related conditions".

Taken altogether, Herbal Angelica may be considered a neuroprotective remedy, pending a larger sample size and multicenter human study.

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How To Get Rid Of Eye Floaters
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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Ligustilide prevents cognitive impairment and attenuates neurotoxicity in D-galactose-induced aging mice brain by Li JJ1, Zhu Q2, Lu YP3, Zhao P3, Feng ZB3, Qian ZM4, Zhu L. (PubMed)

#Cranberry Improves Metabolic Syndrome throught its Antioxidant Activity, Researchers Find

Kyle J. Norton

Homocysteine produced in the bloodstream is a common amino acid in the blood from eating meat.
High levels of homocysteine in the blood have increased the risk of heart disease and stroke.

In other words, homocysteine induced atherosclerosis by causing arterial damage, leading to the accumulation and formation of the plaque and blood clot.

Believe it or not, overexpression of homocysteine accompanied by the low levels of vitamins B6, B12, and folate, also have been found in some patients with renal disease.


Dr. Bradley A. Maron, the lead scientist in the examination of the disease associated with hyperhomocysteinemia wrote, "The unique biochemical profile of homocysteine is characterized by chemical reactivity supporting a wide range of molecular effects, and a tendency to promote oxidant stress-induced cellular toxicity".


And, "Numerous epidemiological reports have established hyperhomocysteinemia as an independent risk factor for cardiovascular disease, cerebrovascular disease, dementia-type disorders, and osteoporosis-associated fractures".


Adiponectin is a type of protein associated with the function that regulates glucose levels and fatty acid breakdown.

The protein also plays a critical role in the development of insulin resistance and atherosclerosis. Low levels of adiponectin levels increase the risk of insulin resistance and type 2 diabetes.

In type 2 diabetes, and administration of adiponectin not only lowers plasma glucose levels but also increases insulin sensitivity.

More precisely, in patients with type 2 diabetes, increased levels of adiponectin involved in the enhancement of insulin sensitivity were attributed to the increase of fatty acid oxidation and inhibition of hepatic glucose production.

Dr. Lihn AS in the examining the effects of administration of adiponectin in type 2 diabetes wrote, "adiponectin in addition to possible anti-inflammatory and anti-atherogenic effects appears to be an insulin enhancer, with potential as a new pharmacologic treatment modality of the metabolic syndrome and type 2 diabetes".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the inhibition of cardiovascular risk factors, researchers examined the effects of cranberry juice concomitantly on homocysteine and adiponectin levels in patients with the MetS.

The study included a total of 36 individuals with the MetS divided into two groups: the control group (n 36) and cranberry-treated group(n 20) received cranberry juice (0·7 liters/d) containing 0·4mg folic acid for 60 days.

According to tested analysis, the cranberry-treated group showed an increase in adiponectin involved in regulating glucose levels as well as fatty acid breakdown and a decrease in homocysteine associated with a risk for heart disease comapred to baseline values and the controls.

However, the cranberry-treated group improved MetS without affecting the production of pro-inflammatory cytokines TNF-a, IL-1, and IL-6.

According to the measurement of oxidative stress, the cranberry-treated group also showed decreased lipoperoxidation and protein oxidation levels, compared to the control group.

The results strongly suggested that chronic consumption of cranberry juice for 60 d improves some cardiovascular risk factors.

Based on the findings, researchers concluded. "The present data reinforce the importance of the inverse association between homocysteine and adiponectin and the need for more specifically designed studies on MetS patients.".

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of MetS, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Reduced-energy cranberry juice increases folic acid and adiponectin and reduces homocysteine and oxidative stress in patients with the metabolic syndrome by Simão TN1, Lozovoy MA, Simão AN, Oliveira SR, Venturini D, Morimoto HK, Miglioranza LH, Dichi I. (PubMed)
(2) The Treatment of Hyperhomocysteinemia by Bradley A. Maron, M.D. and Joseph Loscalzo, M.D., Ph.D. (PMC)
(3) Adiponectin: action, regulation, and association to insulin sensitivity by Lihn AS1, Pedersen SB, Richelsen B. (PubMed)

#ChasteTreeBerries Process Both Extrogenic and Anti-Estrogenic Activties Depending on the Levels of Estrogen in the Body

Kyle J. Norton

Chaste tree berries possess both estrogenic and anti-estrogenic properties may be considered a functional food for women with delayed aging progression, restored hormone balance in ameliorated menstrual disorders, and alleviated menopausal symptoms, and more........

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belongings to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.


Estrogenic Property
Chaste tree berry (Vitex agnus-castus L.) displaced estrogenic ability induced the reaction of estrogen from the binding site of estrogen receptors alpha (ERalpha) and beta (ERbeta), in ameliorated the deregulation of 17β-Estradiol (E2) in exhibited the initiation and progression of cell malignancies, affecting various aspect in women body, a study by respectable Institute suggested.

According to the University of Illinois at Chicago, linoleic acid isolated from the extract of Vitex agnus-castus exerted estrogenic activity in binding to estrogen receptors, inducing certain estrogen-inducible gene expression in preserving the integrity of the genome, presented in a cell or organism.

Dr. Jarry H, the lead author in the study of "evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones" found that besides linoleic acid, flavones derivative vitexin and Pendleton. isolated from Vitex agnus-castus (VAC) also expressed estrogenic effect as most active ERss-selective phytoestrogens.

Anti-estrogen Property
Chaste tree berry(Vitex agnus-castus), also processes anti-estrogenic properties in binding the estrogen receptors for a balance between the activities of estrogen receptor ERα or ERβ.

Anti-estrogenic effects are the action of binding the estrogen receptor(ERα ) and/ERβ in inhibiting the excessive levels of estrogen circulating in the body.

According to the University of Alabama in Huntsville, in the study of the potential effect of estrogen mimics or anti-estrogens in phytochemicals of popular dietary herbal supplements, researchers found that almost all herbal supplements containing phytochemical components showed a capability in binding to the human estrogen receptor and exhibit selective estrogen receptor modulation, including chaste tree berry.

Casticin, a flavonoid isolated from Vitex rotundifolia, significantly expressed an anti-estrogenic effect in reduced the prolactin release stimulated by E2 in induced inhibition of ERα mRNA expression in a concentration-dependent manner, through its anti-estrogenic effect.

In hyperprolactinemia (MIHP) induced by administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, for 10 d) in SD rats, application of casticin (10, 20, and 40 mg/kg, ip, for 7 d) reduced serum prolactin levels by 33.9%, 54.3%, and 64.7% and at(1 and 10 micromol/L) inhibited E2-induced pituitary cell proliferation by 27.7% and 42.1%, respectively through reduced levels of 17β-Estradiol (E2) significantly.

More importantly, oral administration of capsaicin, a flavonoid isolated from Vitex rotundifolia displayed an anti-estrogenic activity in decrease excessive levels of 17β-Estradiol (E2) significantly


Chaste tree berry(Vitex agnus-castus) exerts estrogenic components of plant extracts may constitute a potential use for some dietary supplements in humans for the treatment of various estrogen-related syndromes and diseases, including breast and prostate cancers, menopausal symptoms, osteoporosis, atherosclerosis and stroke, and neurodegeneration and anti-estrogenic effects in binding estrogen receptor site to preserve the balancing of hormone expression of estrogen through ER-alpha and ERBeta inhibition and exhibition by regulating the function of some estrogen-inducible genes.

In other words, chaste tree berry stimulated estrogen receptors in the release of estrogen into the blood in case of deficiency or inhibited extra levels of estrogen in case of excess in maintenance hormone balancing with other sex hormones.


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Sources

(1) Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry) by Liu J1, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR.(PubMed)
(2) Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones by Jarry H1, Spengler B, Porzel A, Schmidt J, Wuttke W, Christoffel V.(PubMed)
(3) Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms by Liu J1, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL.(PubMed)
(4) Health effects of phytoestrogens by Branca F1, Lorenzetti S.(PubMed)
(5) A molecular docking study of phytochemical estrogen mimics from dietary herbal supplements by Powers CN1, Setzer WN1.(PubMed)
(6) Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro by YE Q1, ZHANG QY, ZHENG CJ, WANG Y, QIN LP.(PubMed)

#EthanolicExtract of #ChasteTreeBerry Intake Increases Progesterone Levels and Decreases Levels of #Estrogen and Testosterone in Women

Kyle J. Norton

A renowned institute study suggested that Chaste tree berries may be a functional food for the treatment of female sex hormone deficiency.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.

According to a joint study led by the Ahvaz Jundishapur University of Medical Sciences, orally administrated Vitex agnus-castus fruit improved hypothalamic-pituitary-gonadal axis in the regulation of the reproductive system and immune system in free radical scavenger activities involved natural aging, in a d-galactose induced aging model in female mice.

Mice injected with d-galactose (500 mg/kg/d for 45 days) in seventy-two female NMRI mice (48 3-month-old normal mice and 24 18-24-month-old mice), weighing 30-35 g randomly divided into six groups: control, Vitex, d-galactose, Vitex + d-galactose, Aging, and Vitex + Aging, groups treated with Chaste tree berry or combination with herbal medicine showed a strong effect in increased the levels of malondialdehyde (MDA), follicle-stimulating hormone, and luteinizing hormone.


Dr. Ahangarpour A, the lead researcher said, " Vitex can be suitable for some aging problems such as oxidative stress, female sex hormone deficiency, and an atrophic endometrium".

Furthermore, the testing of flavonoid glycosides, orientin and apigenin 3, 8-di-C-glycosides and iridoid compound, aucubin isolated from the ethanolic extract of Vitex agnus-castus fruits, also showed a significant increase in plasma progesterone and total estrogens levels and reduction in luteinizing and plasma prolactin hormones in two dose levels 0.6 and 1.2 g kg(-1) per body weight (b.w.).

Additionally, the study also found that the ethanolic extract induced a significant increase in the uterine weight which showed an interaction of the sexual hormone of progesterone and estrogen of ovariectomized rats at two dose levels comparable to that of a control group.


Dr. Jillian Stansbury, not the author of the above studies said, "Consumption of Vitex fruits by female chimpanzees as part of their natural diets has been found to dramatically increase progesterone levels in the urine, indicating an overall progesterone effect.34 One hypothesis is that reduced LH allows the follicle-stimulating hormone to dominate and can lead to decreased estrogen and testosterone and a relative increase in progesterone".


Taking together, in women, Chaste Tree Berry may have a strong effect in influencing sex hormones
production in an expression of antioxidant, anti-aging, and normalized hormone activities.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Effects of Vitex agnus-castus fruit on sex hormones and antioxidant indices in a d-galactose-induced aging female mouse model by Ahangarpour A1, Najimi SA2, Farbood Y3.(PubMed)
(2) Gynecological efficacy and chemical investigation of Vitex agnus-castus L. fruit-growing in Egypt by Ibrahim NA1, Shalaby AS, Farag RS, Elbaroty GS, Nofal SM, Hassan EM. (PubMed)
(3) WOMEN’S HERBS” FOR MEN By Editor1 Posted November 8, 2010
In Botanical Medicine, Endocrinology, Fertility, Men's Health, Nature Cure, Oncology, Dr Jillian Stansbury

Indole-3-Carbinol (I3C) Found in Brassica Genus Induces Apoptosis of Epstein-Barr Virus (EBV)-Positive Burkitt's Lymphoma, According to Studies

Kyle J. Norton

Herpesvirus is a large family of DNA viruses that cause diseases, depending on the types of viral infection.
According to viral classification, there are 8 types of herpes virus, including human herpesvirus 1 which causes cold sores around the mouth. and 2 that causes genital herpes, herpes zoster that causes chickenpox and shingles, Epstein-Barr virus that causes infectious mononucleosis, cytomegalovirus (CMV) that causes mononucleosis, Human herpesvirus 6 and 7(HHV6 - 7) that causes roseola and Human herpesvirus 8 (HHV8) that causes cancer, such as Kaposi's Sarcoma.

According to statistics, in the United States, half of teens and adults under age 50 are still infected with the oral herpes virus, and about 1 in 8 have an infection with the genital herpes virus.

All herpes viruses like other viruses are nuclear-replicating, infecting healthy cell nuclei through replication of viral DNA and transcription of viral mRNA.

People infected may experience symptoms of painful sores in the genital area, anus, buttocks, thighs, itching, painful urination, vaginal discharge,..... and tender lumps in the groin.

Epstein-Barr virus (EBV)-positive is early in the course of the illness associated with VCA-IgM antibodies caused by EBV infection.

The Epstein–Barr virus (EBV), is also known as human gammaherpesvirus 4, one of the nine known human herpesvirus types in the herpes family.

Unlike other types of the herpes virus, symptoms of EBV may vary, including extreme fatigue, fever, sore throat, and swollen lymph nodes.

Conventionally, there is no specific treatment for EBV. The most common treatment is to improve quality of life by targeting symptoms such as reducing swelling of tissues with corticosteroids


In finding a potential plant with infectious diseases, researchers compared the effects of indole-3-Carbinol (I3C) a natural product found in broadly consumed plants of the Brassica genus, such as broccoli, cabbage, and cauliflower, effects on the various vegetablesEpstein-Barr virus (EBV)-positive

Based on the tested results, I3C efficiently induced apoptosis in cell lines derived from EBV-positive Burkitt's lymphomas (virus latency I/II).

However, I3C did not have any cytotoxic activity against EBV-negative Burkitt's lymphomas and immortalized EBV-infected lymphoblastoid cell lines (virus latency III).

Furthermore, The effect of I3C on cell viability. in EBV-positive Burkitt's lymphoma was attributed to C6-methylated derivative, but not other 3-substituted indoles.

Moreover, 3C treatment caused apoptosis characterized by loss of cancer cell mitochondria membrane potential and caspase activation by alternating the expression of proteins involved in the control of apoptosis and transcription regulation in EBV-positive Burkitt's lymphoma cell lines.

Particularly, I3C derivative 3,3'-diindolylmethane (DIM) prolonged survival and reduced tumor burden of mice xenotransplanted with EBV-positive Burkitt's lymphoma Daudi cells.

Based on the results, researchers said, "These results, together with previous reports from clinical trials indicating the lack of toxicity in humans of I3C and derivatives, support the use of these compounds as a new therapeutic approach for treating patients with endemic (EBV-positive) Burkitt's lymphoma".

Taken together, the Brassica Genus may be considered the Epstein-Barr virus (EBV)-positive induced cancer remedy, pending the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Indole-3-carbinol induces cMYC and IAP-family downmodulation and promotes apoptosis of Epstein-Barr virus (EBV)-positive but not of EBV-negative Burkitt's lymphoma cell lines by Perez-Chacon G1, de Los Rios C2, Zapata JM. (PubMed)