#Manuka and Clover Honey Exerts a Strong Exert Anti Varicella Zoster Virus (VZV) Activity, Researchers Suggest

Kyle J. Norton

Honey may have a profound effect in reducing the risk and treatment of varicella-zoster virus (VZV), some scientists suggested.
Varicella-zoster virus is a member of the herpes viruses that cause chickenpox in children, teens, and young adults, and shingles and recurrent shingles in adults.

The disease has been found worldwide and is highly contagious.

Chickenpox is usually caused by exposure either through direct contact with a skin lesion or airborne spread from respiratory droplets from infected patients.


In the initial stage of infection, the symptoms usually resolve within 7 to 10 days.

After initial infection, VZV establishes lifelong latency in the cranial nerve and dorsal root ganglia and can reactivate years to decades later.


Reactivation of the dormant virus results in the later years can lead to a painful dermatomal rash followed by pain in the distribution of the rash.

In some cases, the diseases can cause infrequently complications of hepatitis, pancreatitis, pneumonitis, and encephalitis and be life-threatening.

However, some adults and children are more likely to develop such complications from primary infection

According to the statistics, in the US, more than 90% of adults acquired the disease in childhood, due to being vaccinated with the live virus vaccine.

Dr. Maria A. Nagel and colleagues in the summary of the disease associated with the Varicella zoster virus (VZV), said, "With advancing age or immunosuppression, cell-mediated immunity to VZV declines and virus reactivates to cause zoster (shingles), which can occur anywhere on the body"

" Skin lesions resolve within 1-2 weeks, while complete cessation of pain usually takes 4-6 weeks" and "Zoster can be followed by chronic pain (postherpetic neuralgia), cranial nerve palsies, zoster paresis, meningoencephalitis, cerebellitis, myelopathy, multiple ocular disorders and vasculopathy that can mimic giant cell arteritis. All of the neurological and ocular disorders listed above may also develop without rash".

These results clearly suggested that the elderly due to the increase in age and weakened immune system, are considered to be the risk group for the development of serious and even life-threatening complications.

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.

With an aim to find a natural ingredient ]or whole food for the prevention and treatment of varicella-zoster virus (VZV) infection, researchers at the University of Colorado Denver evaluated the anti-viral effect of honey on the varicella-zoster virus in vitro.

The tested VZV was obtained from a zoster vesicle.
Manuka and clover kinds of honey were used at concentrations ranging from 0-6% wt/vol in the study.
During the experiment, various concentrations of manuka and clover honey were added to the tissue culture medium of the VZV-infected human malignant melanoma (MeWo) cell.


According to the assay, both types of honey demonstrated significant antiviral activity against the varicella-zoster virus with an approximate EC50 = 4.5 % (wt/vol).


In the final report, researchers suggested honey can be considered an anti-varicella-zoster virus agent because it is an inexpensive product that can be bought at any grocery store and convenient for skin application.

Dr. Shahzad A, said, "Honey may be an excellent remedy to treat zoster rash in developing countries where antiviral drugs are expensive or not easily available".

Taken altogether, honey may be used as a topical function food for the prevention of varicella-zoster virus (VZV) infection and combined with primary therapy for the treatment of chickenpox in children and shingles and recurrent shingles in adults with no side effects.

However, further data collection large example size, and multi-center studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of honey anti chickenpox and anti shingles possibilities.

.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) In vitro antiviral activity of honey against varicella zoster virus (VZV): A translational medicine study for potential remedy for shingles by Shahzad A1, Cohrs RJ. (PubMed)
(2) Varicella Zoster Complications by Maria A. Nagel, MDa, and Don Gilden, MD. (PubMed)

#Intake of RAW Fruits and Vegetables Regularly are Associated with a Reduced Risk of #PancreaticCancer, Researchers Suggest

Kyle J. Norton

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, the pancreas aids the digestive system in breaking down carbohydrates, proteins, and lipids.
Traditional Chinese medicine suggests that the pancreas is a vital organ responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our bodies.

Pancreatic cancer is a chronic condition characterized by cell growth irregularly in the tissues of the pancreas.


At the early stage, patients with pancreatic cancer may be asymptomatic. However, at the later stage, besides the common symptoms shared by all types of cancer such as unintended weight loss, loss of appetite, fatigue, and gastrointestinal discomforts, patients with the condition may also experience localized symptoms such as internal bleeding and severe pain due to the oversize tumor which suppresses the nerve cells and blood vessels.

According to statistics, every year, approximately, over 55,000 adults in the United States are diagnosed with pancreatic cancer, accounting for 3% of all cancers and 7% of all cancer deaths.

The survival rate of pancreatic cancer even if diagnosed early is very low compared to other types of cancer. The 5-year survival rate for stage IA pancreatic cancer is only14%.

Researchers do not know what causes pancreatic cancer. Scientists do not know the exact causes of pancreatic cancers, but they do know several risk factors that can make a person more likely to get the disease, including the genetic and acquired genetic mutation of p16 and TP53 and KRAS, BRAF, and DPC4 (SMAD4).

Other prevalent risk factors, including long-term use of tobacco, exposure to certain chemicals, overweight, and obesity, and unpreventable risk factors of family history, gender, the increase of age, and ethnicity are associated with the early onset of pancreatic cancer.

Researchers at the Johns Hopkins Medical Center suggested an unhealthy diet high in meats, cholesterol, fried foods, and nitrosamines may increase risk, while diets high in fruits and vegetables reduce the risk of pancreatic cancer.

However, most people with some of the above risk factors do not get the disease.

In finding a potent ingredient for the treatment of diseases associated with abnormal cell growth, researchers investigated the consumption of raw fruits and vegetables' effects on pancreatic cancer.

According to the dietary habits and medical history variables in a prospective study of fatal pancreas cancer among 34,000 California Seventh-day Adventists between 1976 and 1983. Forty deaths from pancreas cancer occurred during the follow-up period,

* Compared to all US whites, Adventists experienced a decreased risk of pancreas cancer death (standardized mortality ratio [SMR] = 72 for men; 90 for women),

* Furthermore, increasing consumption of vegetarian protein products, beans, lentils, and peas, as well as dried fruit, was associated with highly significant protective relationships to pancreas cancer risk compared to increased risk in increasing meat, egg, and coffee consumption.

In other words, regular consumption of raw fruits and vegetables exerted protective relationships associated with a protease-inhibitor content that decreases the risk of pancreas cancer in high-risk patients.

Taken together, fruits and vegetables may be considered a functional food for the prevention of pancreas cancer, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary habits and past medical history as related to fatal pancreas cancer risk among Adventists by Mills PK1, Beeson WL, Abbey DE, Fraser GE, Phillips RL.(PubMed)

#Ethanolic #Extract Found in #CynometraCauliflora Leaves Inhibits Parameters Associated with the Onset of Obesity, Scientists Say

Kyle J. Norton

Obesity is a chronic and medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.

According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.

Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.


In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.

According to the BMI index, a person is considered overweight, if he/she has a BMI between 25 to 29.9 kg/m2. A BMI of 30 kg/m2 or more is an indication of obesity.

In other words, obesity is a progressive chronic disease characterized by abnormal fat accumulation in the body tissues that may impair health.

Similar to other chronic medical conditions including diabetes, cardiovascular disease or high blood pressure, obesity has recently become a serious health problem in the US as nearly 35% of Americans are obese accompanied by a similar percentage of overweight adults.

Obesity and overweight in the U.S. economy have eclipsed $1.7 trillion, equivalent to 9.3 percent of the nation's gross domestic product, according to a new overweight report on chronic diseases.

Dr. Maximilian Tremmel, the lead scientist in a systematic literature review of the economic burden of obesity, wrote, " almost half of the world’s adult population will be overweight or obese by 2030 if the prevalence continues on the current trend [6] and consequently also the costs attributable to obesity will increase".

And, "A useful example for rapidly rising costs attributable to obesity from these selected studies are the two mentioned studies from Germany [44,46]. The results of the two papers together show that total societal costs in Germany due to obesity have increased from €9.8 million to €12.2 million between 2002 and 2008. Therefore, public health interventions should focus on the prevention of obesity as soon as possible, ideally at a young age".

Cynometra cauliflora is a species of the genus Cynometra, native to Malaysia, and found mainly in northern Peninsular Malaysia.

In finding a potential phytochemical for the prevention and treatment of chronic diseases, researchers examined the anti-obesity and lipid-lowering effects of ethanolic extract of C. cauliflora leaves and its major compound (vitexin) in C57BL/6 obese mice induced by a high-fat diet (HFD).

The study included male C57BL/6 mice induced obesity by feeding with HFD (60% fat) for 16 weeks followed by the treatment that starts during the last 8 weeks of HFD feeding with C. cauliflora leaf extract at 200 and 400 mg/kg/day, orlistat (10 mg/kg) and vitexin (10 mg/kg).

According to the chemical analysis,
* The oral administration of C. cauliflora (400 and 200 mg/kg) and vitexin significantly reduced body weight, adipose tissue and liver weight, and lipid accumulation in the liver compared to the control HFD group.

* Both doses of C. cauliflora also significantly (P ≤ 0.05) decreased serum triglyceride, LDL, lipase, IL-6, peptide YY, resistin levels, hyperglycemia, hyperinsulinemia, and hyperleptinemia compared to the control HFD group.

* C. cauliflora significantly up-regulated the expression of adiponectin, Glut4, Mtor, IRS-1 and InsR genes associated with the sustaining weight loss and significantly decreased the expression of Lepr in white adipose tissue involved in stimulating weight gain.

Based on the findings, researchers said, "This study shows interesting outcomes of C. cauliflora against HFD-induced obesity and associated metabolic abnormalities".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of bacterial infectious diseases, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cynometra cauliflora Linn. Attenuates metabolic abnormalities in high-fat diet-induced obese mice by Seyedan A1, Mohamed Z2, Alshagga MA3, Koosha S4, Alshawsh MA. (PubMed)
(2) Economic Burden of Obesity: A Systematic Literature Review by Maximilian Tremmel,1,* Ulf-G. Gerdtham,2,3,4 Peter M. Nilsson,5 and Sanjib Saha. (PMC)

#Betacyanins Process a Strong #Antioxidant Capacity According to Studies

Kyle J. Norton

Oxidative stress is a medical condition caused by the unbalanced ratio of the levels of free radical and antioxidant enzymes produced by the host.
In fact, free radicals exist everywhere including the airs we breathe, the thing we eat and the environment we contact, particularly, cell metabolism in the body.

Epidemiologically, overexpression of free radicals has been found to induce damage to the cell, lipid, proteins, and alternation of cell DNA, leading to chronic diseases, such as cardiovascular diseases, diabetes, and particularly, cancer.

Other diseases such as hypertension, dyslipidemia, peripheral artery disease, metabolic syndrome, diabetes, and obesity are also found in patients with oxidative stress.

In spite of free radicals' harmful effects, one must understand that cellular oxygen species (ROS), are necessary with a moderate amount to protect our body in the mediation of antimicrobial infection, detoxification of potentially toxic compounds, and elimination of cancerous and other life-threatening cells through cytotoxicity.

Free radicals are unstable atoms with an unpair of electrons on the outer ring of molecules. Therefore, in order for them to become stable, they constantly seek to donate or intercept the electron from other stable atoms, leading to a chain reaction that can not be stopped until all unpaired electrons are paired or inhibited by antioxidants.
Antioxidants are stable molecules that inhibit free radicals.

Free radicals such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, myeloperoxidase, superoxide dismutase, and glutathione peroxidase and antioxidants such as glutathione peroxidase, catalase, and superoxide dismutase (SOD) also act on specific oxidative pathways involving both pro-oxidant and antioxidant enzymes to maintain the healthy ratio in the body.


Normally, in a healthy individual, antioxidant enzymes produced by the liver are more than enough to counter levels of free radicals in the body. However, for people with weakened immune systems intake of dietary antioxidants or antioxidant supplements may be necessary.

Dr. Pignatelli P. the lead scientist in the investigation of the relationship between oxidative stress and antioxidants in CVD wrote, " 1) the most relevant enzyme systems involved in the formation and detoxification of ROS, 2) the relationship between oxidative stress and cardiovascular risk, and 3) therapeutic implications to modulate oxidative stress".

In other words, by understanding the interaction of free radicals and antioxidant, diseases associated with oxidative stress may be preventable.

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a potential compound for the treatment of diseases associated with oxidative stress, researchers assessed the antioxidant capacity of betacyanins as indole-derived plant pigments, such as betanin, phyllocactin, and betanidin.

According to the test from the peroxyl radical generating system, betacyanins exerted a significant peroxyl radical scavenging capacity at a dose-dependent in the low concentration range (25-100 nM).

In chemical analysis, betanidin, betanin, and phyllocactin demonstrated antioxidant capacity at the order of 10.70, 3.31, and 2.83 mol-TEA/mol-compound respectively.

The IC₅₀ values (μM) of nitrogen radical scavenging activity of betanin, phyllocactin, and betanidin.was 24.48, 17.51, and 6.81, respectively.

In other words, betanidin was the strongest antioxdant that exerted radical scavenging activity compared to those of betanin, and phyllocactin.

Furthermore, the expression of free radical NO was reduced by the administration of betacyanin in the low concentration range of 2.5-20 μM.


Based on the results, researchers said, "These results indicated that betacyanins have a strong antioxidant capacity, particularly betanidin with a catechol group had higher activity than those of the glycoside of betacyanins".

And, "This study demonstrated that the betacyanins will be useful as natural pigments to provide defense against oxidative stress".

Taken together, betacyanins may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Betacyanins from Portulaca oleracea L. ameliorate cognition deficits and attenuate oxidative induced by D-galactose in the brains of senescent mice by Chang-Quan Wang, and Gui-Qin Yang. (Research Gate)
(2) Antioxidant capacity of betacyanins as radical scavengers for peroxyl radical and nitric oxide by Taira J1, Tsuchida E2, Katoh MC2, Uehara M2, Ogi T. (PubMed)
(3) Oxidative stress and cardiovascular disease: new insights by Pignatelli P1, Menichelli D, Pastori D, Violi F. (PubMed)

#Cranberry, a Promising Gingipain and Periodontitis inhibitor, Researchers Find

Kyle J. Norton


Periodontitis is a serious case of gingivitis associated with gum infection that damages the soft tissue and destroys the bone that supports your teeth as a result of long-term poor oral hygiene
Periodontitis is preventable if the progression of gingivitis stages is stopped


Gingivitis is a common and mild form of periodontal disease caused by inflammation of the gingiva, leading to symptoms of irritation, redness, and swelling of the gum that lines the base of the teeth.

Gingivitis dental plaques formed around the base of the teeth are sticky biofilms of bacteria associated with the interaction of the food intake and bacteria in the mouth. Over time, if untreated, the condition can lead to periodontitis and advanced periodontitis.

At this early stage, the bone and connective tissue that hold the teeth in place are not yet affected. The problems can be reversed by more frequent and proper brushing and flossing.

Epidemiologically, risk factors that induce the onset of gingivitis are smoking or chewing tobacco. diabetes and long-term use of certain medications including oral contraceptives, steroids, anticonvulsants, and calcium channel blockers.

Some people under the treatment of chemotherapy may also experience symptoms of gingivitis.

The Colgate Professional the examined the symptoms and advised that if you have experienced some of the symptoms that do not heal themselves in a short time, such as puffy or swollen, or tender, bleeding during brushing or flossing,... and constant bad breath or a bad taste in your mouth, you may have gingivitis.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of periodontitis, researchers examined the effect of cranberry and rice extracts as a potent gingipain inhibitor.

Based on the tested analysis, cranberry and rice extracts interfere with gingipain activity that causes the slowing down the progression of adult periodontitis.

Furthermore, the extracts prevented the growth and biofilm formation of periodontal pathogens and induced the onset of periodontitis.

Moreover, the extracts also inhibited a broad spectrum of host proteases in the induction of undesirable side effects

As of today, the ideal gingipain inhibitor has yet to be discovered, however, cranberry and rice extracts may be a promising gingipain inhibitor compared to gingipain N-terminal pro domains, synthetic compounds, antibiotics, antiseptics, antibodies, and bacteria which may induce undesirable side effects

The results strongly suggested that cranberry promotes oral health by inhibiting the onset and progression of periodontitis through its anti-bacterial activity


Taken together, cranberry may be considered a remedy for the prevention and treatment of periodontitis, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases by Olsen I1, Potempa J. (PubMed)

#Phytochemical #Beetroot Extract Normalizes Your High Blood Pressure Induced by Dexamethasone, Researchers Say

Kyle J. Norton

Hypertension is a medical condition caused by abnormally high pressure that presses against the wall of the arteries, affecting the heart's function in pumping blood to the body.

Hypertension is a member of the cluster of metabolic syndrome that facilitates the risk of cardiovascular disease and type 2 diabetes

Epidemiologically, uncontrolled high blood pressure has been found to induce the risk of heart attack and stroke.

Most patients with high blood pressure are asymptomatic. However, the long-term elevated force of the blood against your artery walls may result in symptoms of headache, dizziness, shortness of breath, early signs of heart disease, and stroke.


According to the statistics provided by the CDC, approximately 75 million American adults (32%) have high blood pressure. In other words, 1 in every 3 American adults is affected by high blood pressure.


Believe it or not, the actual numbers of high blood pressure are substantially higher if people with the stage of prehypertension are also taken into account.


Sadly, only half of the people with high blood pressure in the US are under control.

There are 2 types of hypertension, including primary hypertension which takes years to develop, and secondary hypertension associated with other medical conditions, such as kidney and thyroid disease.


Out of many prevalent factors, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a direct implication on the onset of hypertension in American adults.

Dr.Dixon W. Wilde, the lead scientist wrote, "Dietary fat contributes to the elevation of blood pressure and increases the risk of stroke and coronary artery disease".


And, "an elevation of plasma FAs may contribute to the development of hypertension via a process involving the elevation of Ca2+ current density and alteration of channel kinetics in the vascular smooth muscle membrane".

The results strongly suggested the high-fat diet-induced elevated FAs associated with the alternation of vascular smooth muscle membrane in the initiation of hypertension.


Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

In finding a potential ingredient for the treatment of hypertension, researchers examined the effect of betanin against a hypertensive animal model.

The study included animals divided into six main groups with each group containing 5 animals.

* Group I received the vehicle,

* Group II received dexamethasone injection (20 µg/kg/day, s.c.) for 14 days,

* Group III received an extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days,

* Group IV received an extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days,

* Group V received dexamethasone injection (20 ugs/kg/day, s.c.) and extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days and

* Group VI received dexamethasone (DEXA) injection (20 µg/kg/day, s.c.) and extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days.

At the end of the experiment after 14 days, the group treated with a combination of dexamethasone and beta vulgaris (100 and 300 mg/kg p.o. for 14 days) showed a significant decrease in heart rate compared to the Dexamethasone group.

According to the tested assays, the dexamethasone-treated group showed a significant elevation (p<0.05) in systolic blood pressure (SBP), and vascular reactivity changes to Catecholamine, compared to the control group.


Injection of beta vulgaris extract (100, 300 mg/kg/day, p.o.) for 14 days in dexamethasone-administered rats significantly (p<0.05) demonstrated a significant reversal of such change.

Based on the finding, researchers wrote, "The methanolic-HCl extract of Beta vulgaris has antihypertensive activity in Dexamethasone models".


In other words, betanin detected by phytochemical analysis from beta vulgaris extract protected the heart function and blood vessels through its antihypertensive properties.

Taken altogether, betanin may be considered a supplement for the prevention and treatment of hypertension, pending the confirmation of a larger sample size and multicenter human study.

Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihypertensive activity of Beta vulgaris on dexamethasone-induced hypertension in rats by Dignesh Patel, Rupali A Patil, and Alkesh Patel. (Research Gate)
(2) High-Fat Diet Elevates Blood Pressure and Cerebrovascular Muscle Ca2+Current
Dixon W. Wilde, Kenneth D. Massey, Glenn K. Walker, Alan Vollmer, and Roger J. Grekin. (Hypertension)

#Phytochemical #Betanin Inhibits #LungCancer Through Its #Antioxidant and Anti-Inflammatory Mechanisms, According to Studies

Kyle J. Norton

Antioxidants are stable atoms that inhibit oxidation induced by free radicals.
There are 2 types of antioxidants found in the human body, including
* Internally, antioxidant enzymes produced by the liver

* Externally, antioxidants are produced by the intake of antioxidants-rich food.

Free radicals, in fact, are everywhere, any atoms with oxygen molecules that have an unpaired electron on the outermost ring are considered free radicals.

Free radicals are unstable atoms. Therefore, in order to maintain stable, free radicals are ready to donate or intercept an electron from other stable atoms, leading to a chain of reaction that can not be stopped until all outermost ring electrons are paired or inhibited by antioxidants.

An unbalanced ratio of the levels of free radicals and antioxidants over the long-term can induce oxidative stress, a condition that causes protein and lipid damage and alternation of cell DNA.

In a healthy individual, antioxidants produced by the body are normally good enough to neutralize free radicals produced by the body in support of cellular metabolism and by external sources, such as the air we breathe and the foods we eat.

Diseases associated with oxidative stress including cardiovascular disease, type II diabetes, and cancer.


However, for people with a weakened immune system such as the elderly, the intake of antioxidants may be necessary.

Dr. wrote, "Oxidant-mediated tissue injury is a particular hazard to the immune system since phagocytic cells produce reactive oxygen species as part of the body's defense against infection".

And, " Although more striking effects have been observed in the elderly, there is also evidence that antioxidant nutrients can modify cell-mediated immune responses in younger individuals".

Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a potential compound associated with the reduced risk of oxidative stress, researchers examined the antioxidant activity of betanin on a rat paraquat-induced acute lung injury (ALI) model.

The study included paraquat injected intraperitoneally at a single dose of 20 mg/kg body weight, and betanin (25 and 100 mg/kg/d) following the orally administered 3 days before and 2 days after paraquat administration in selected rats.

According to the results of tested assays on rats sacrificed 24 hours after the last betanin dosage, and lung tissue and bronchoalveolar lavage fluid (BALF) collected, rats treated only with paraquat showed an extensive lung injury characteristic of ALI, including increased malondialdehyde (MDA) and myeloperoxidase (MPO) levels, lung oxidative stress markers, reduced antioxidant activity and increased expression of pro-inflammatory proteins in the lung.

Rat treated with betanin attenuated all such changes, in a dose-dependent manner.

In other words, betanin ameliorated the effects of paraquat-induced ALI probably via antioxidant and anti-inflammatory mechanisms.

In order to maintain the release of betanin, researchers incorporated red beetroot (RB) powder into starch-based bio-elastomers to obtain flexible biocomposites with tunable antioxidant properties.


According to free radical assays, betanin released by the corporation demonstrated highly efficient antioxidant scavenging activity against 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS(+)) compared to the application of red beetroot (RB) powder.

More precisely, red beetroot (RB) powder incorporated into starch-based bio-elastomers is more effective in inhibiting oxidation caused by free radicals compared to red beetroot (RB) powder.


Based on the results, Dr. Tran TN, the lead scientist wrote, "Hence, as a simple but intelligent biomaterial consisting of mainly edible starch and RB powder the present bio-elastomers can be used (to provide antioxidation) in the active packaging for a variety of pharmaceutical, medical, and food applications".
Taken altogether, betanin may be considered a supplement to improve the antioxidant profile of patients, pending the confirmation of a larger sample size and multicenter human study.

Intake of betanin in supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Natural antioxidant betanin protects rats from paraquat-induced acute lung injury interstitial pneumonia by Han J1, Ma D1, Zhang M1, Yang X1, Tan D. (PubMed)
(2) Starch-based bio-elastomers functionalized with red beetroot natural antioxidant by Tran TN1, Athanassiou A2, Basit A3, Bayer IS. (PubMed)
(3) Effects of dietary antioxidants on the immune function of middle-aged adults by Hughes DA. (PubMed)