Kyle J. Norton
Oxidative stress is a medical condition caused by the unbalanced ratio of the levels of free radical and antioxidant enzymes produced by the host.
In fact, free radicals exist everywhere including the airs we breathe, the thing we eat and the environment we contact, particularly, cell metabolism in the body.
Epidemiologically, overexpression of free radicals has been found to induce damage to the cell, lipid, proteins, and alternation of cell DNA, leading to chronic diseases, such as cardiovascular diseases, diabetes, and particularly, cancer.
Other diseases such as hypertension, dyslipidemia, peripheral artery disease, metabolic syndrome, diabetes, and obesity are also found in patients with oxidative stress.
In spite of free radicals' harmful effects, one must understand that cellular oxygen species (ROS), are necessary with a moderate amount to protect our body in the mediation of antimicrobial infection, detoxification of potentially toxic compounds, and elimination of cancerous and other life-threatening cells through cytotoxicity.
Free radicals are unstable atoms with an unpair of electrons on the outer ring of molecules. Therefore, in order for them to become stable, they constantly seek to donate or intercept the electron from other stable atoms, leading to a chain reaction that can not be stopped until all unpaired electrons are paired or inhibited by antioxidants.
Antioxidants are stable molecules that inhibit free radicals.
Free radicals such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, myeloperoxidase, superoxide dismutase, and glutathione peroxidase and antioxidants such as glutathione peroxidase, catalase, and superoxide dismutase (SOD) also act on specific oxidative pathways involving both pro-oxidant and antioxidant enzymes to maintain the healthy ratio in the body.
Normally, in a healthy individual, antioxidant enzymes produced by the liver are more than enough to counter levels of free radicals in the body. However, for people with weakened immune systems intake of dietary antioxidants or antioxidant supplements may be necessary.
Dr. Pignatelli P. the lead scientist in the investigation of the relationship between oxidative stress and antioxidants in CVD wrote, " 1) the most relevant enzyme systems involved in the formation and detoxification of ROS, 2) the relationship between oxidative stress and cardiovascular risk, and 3) therapeutic implications to modulate oxidative stress".
In other words, by understanding the interaction of free radicals and antioxidant, diseases associated with oxidative stress may be preventable.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the treatment of diseases associated with oxidative stress, researchers assessed the antioxidant capacity of betacyanins as indole-derived plant pigments, such as betanin, phyllocactin, and betanidin.
According to the test from the peroxyl radical generating system, betacyanins exerted a significant peroxyl radical scavenging capacity at a dose-dependent in the low concentration range (25-100 nM).
In chemical analysis, betanidin, betanin, and phyllocactin demonstrated antioxidant capacity at the order of 10.70, 3.31, and 2.83 mol-TEA/mol-compound respectively.
The IC₅₀ values (μM) of nitrogen radical scavenging activity of betanin, phyllocactin, and betanidin.was 24.48, 17.51, and 6.81, respectively.
In other words, betanidin was the strongest antioxdant that exerted radical scavenging activity compared to those of betanin, and phyllocactin.
Furthermore, the expression of free radical NO was reduced by the administration of betacyanin in the low concentration range of 2.5-20 μM.
Based on the results, researchers said, "These results indicated that betacyanins have a strong antioxidant capacity, particularly betanidin with a catechol group had higher activity than those of the glycoside of betacyanins".
And, "This study demonstrated that the betacyanins will be useful as natural pigments to provide defense against oxidative stress".
Taken together, betacyanins may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betacyanins from Portulaca oleracea L. ameliorate cognition deficits and attenuate oxidative induced by D-galactose in the brains of senescent mice by Chang-Quan Wang, and Gui-Qin Yang. (Research Gate)
(2) Antioxidant capacity of betacyanins as radical scavengers for peroxyl radical and nitric oxide by Taira J1, Tsuchida E2, Katoh MC2, Uehara M2, Ogi T. (PubMed)
(3) Oxidative stress and cardiovascular disease: new insights by Pignatelli P1, Menichelli D, Pastori D, Violi F. (PubMed)
Saturday, 9 September 2023
#Cranberry, a Promising Gingipain and Periodontitis inhibitor, Researchers Find
Kyle J. Norton
Periodontitis is a serious case of gingivitis associated with gum infection that damages the soft tissue and destroys the bone that supports your teeth as a result of long-term poor oral hygiene
Periodontitis is preventable if the progression of gingivitis stages is stopped
Gingivitis is a common and mild form of periodontal disease caused by inflammation of the gingiva, leading to symptoms of irritation, redness, and swelling of the gum that lines the base of the teeth.
Gingivitis dental plaques formed around the base of the teeth are sticky biofilms of bacteria associated with the interaction of the food intake and bacteria in the mouth. Over time, if untreated, the condition can lead to periodontitis and advanced periodontitis.
At this early stage, the bone and connective tissue that hold the teeth in place are not yet affected. The problems can be reversed by more frequent and proper brushing and flossing.
Epidemiologically, risk factors that induce the onset of gingivitis are smoking or chewing tobacco. diabetes and long-term use of certain medications including oral contraceptives, steroids, anticonvulsants, and calcium channel blockers.
Some people under the treatment of chemotherapy may also experience symptoms of gingivitis.
The Colgate Professional the examined the symptoms and advised that if you have experienced some of the symptoms that do not heal themselves in a short time, such as puffy or swollen, or tender, bleeding during brushing or flossing,... and constant bad breath or a bad taste in your mouth, you may have gingivitis.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of periodontitis, researchers examined the effect of cranberry and rice extracts as a potent gingipain inhibitor.
Based on the tested analysis, cranberry and rice extracts interfere with gingipain activity that causes the slowing down the progression of adult periodontitis.
Furthermore, the extracts prevented the growth and biofilm formation of periodontal pathogens and induced the onset of periodontitis.
Moreover, the extracts also inhibited a broad spectrum of host proteases in the induction of undesirable side effects
As of today, the ideal gingipain inhibitor has yet to be discovered, however, cranberry and rice extracts may be a promising gingipain inhibitor compared to gingipain N-terminal pro domains, synthetic compounds, antibiotics, antiseptics, antibodies, and bacteria which may induce undesirable side effects
The results strongly suggested that cranberry promotes oral health by inhibiting the onset and progression of periodontitis through its anti-bacterial activity
Taken together, cranberry may be considered a remedy for the prevention and treatment of periodontitis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases by Olsen I1, Potempa J. (PubMed)
Periodontitis is a serious case of gingivitis associated with gum infection that damages the soft tissue and destroys the bone that supports your teeth as a result of long-term poor oral hygiene
Periodontitis is preventable if the progression of gingivitis stages is stopped
Gingivitis is a common and mild form of periodontal disease caused by inflammation of the gingiva, leading to symptoms of irritation, redness, and swelling of the gum that lines the base of the teeth.
Gingivitis dental plaques formed around the base of the teeth are sticky biofilms of bacteria associated with the interaction of the food intake and bacteria in the mouth. Over time, if untreated, the condition can lead to periodontitis and advanced periodontitis.
At this early stage, the bone and connective tissue that hold the teeth in place are not yet affected. The problems can be reversed by more frequent and proper brushing and flossing.
Epidemiologically, risk factors that induce the onset of gingivitis are smoking or chewing tobacco. diabetes and long-term use of certain medications including oral contraceptives, steroids, anticonvulsants, and calcium channel blockers.
Some people under the treatment of chemotherapy may also experience symptoms of gingivitis.
The Colgate Professional the examined the symptoms and advised that if you have experienced some of the symptoms that do not heal themselves in a short time, such as puffy or swollen, or tender, bleeding during brushing or flossing,... and constant bad breath or a bad taste in your mouth, you may have gingivitis.
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of periodontitis, researchers examined the effect of cranberry and rice extracts as a potent gingipain inhibitor.
Based on the tested analysis, cranberry and rice extracts interfere with gingipain activity that causes the slowing down the progression of adult periodontitis.
Furthermore, the extracts prevented the growth and biofilm formation of periodontal pathogens and induced the onset of periodontitis.
Moreover, the extracts also inhibited a broad spectrum of host proteases in the induction of undesirable side effects
As of today, the ideal gingipain inhibitor has yet to be discovered, however, cranberry and rice extracts may be a promising gingipain inhibitor compared to gingipain N-terminal pro domains, synthetic compounds, antibiotics, antiseptics, antibodies, and bacteria which may induce undesirable side effects
The results strongly suggested that cranberry promotes oral health by inhibiting the onset and progression of periodontitis through its anti-bacterial activity
Taken together, cranberry may be considered a remedy for the prevention and treatment of periodontitis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases by Olsen I1, Potempa J. (PubMed)
#Phytochemical #Beetroot Extract Normalizes Your High Blood Pressure Induced by Dexamethasone, Researchers Say
Kyle J. Norton
Hypertension is a medical condition caused by abnormally high pressure that presses against the wall of the arteries, affecting the heart's function in pumping blood to the body.
Hypertension is a member of the cluster of metabolic syndrome that facilitates the risk of cardiovascular disease and type 2 diabetes
Epidemiologically, uncontrolled high blood pressure has been found to induce the risk of heart attack and stroke.
Most patients with high blood pressure are asymptomatic. However, the long-term elevated force of the blood against your artery walls may result in symptoms of headache, dizziness, shortness of breath, early signs of heart disease, and stroke.
According to the statistics provided by the CDC, approximately 75 million American adults (32%) have high blood pressure. In other words, 1 in every 3 American adults is affected by high blood pressure.
Believe it or not, the actual numbers of high blood pressure are substantially higher if people with the stage of prehypertension are also taken into account.
Sadly, only half of the people with high blood pressure in the US are under control.
There are 2 types of hypertension, including primary hypertension which takes years to develop, and secondary hypertension associated with other medical conditions, such as kidney and thyroid disease.
Out of many prevalent factors, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a direct implication on the onset of hypertension in American adults.
Dr.Dixon W. Wilde, the lead scientist wrote, "Dietary fat contributes to the elevation of blood pressure and increases the risk of stroke and coronary artery disease".
And, "an elevation of plasma FAs may contribute to the development of hypertension via a process involving the elevation of Ca2+ current density and alteration of channel kinetics in the vascular smooth muscle membrane".
The results strongly suggested the high-fat diet-induced elevated FAs associated with the alternation of vascular smooth muscle membrane in the initiation of hypertension.
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In finding a potential ingredient for the treatment of hypertension, researchers examined the effect of betanin against a hypertensive animal model.
The study included animals divided into six main groups with each group containing 5 animals.
* Group I received the vehicle,
* Group II received dexamethasone injection (20 µg/kg/day, s.c.) for 14 days,
* Group III received an extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days,
* Group IV received an extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days,
* Group V received dexamethasone injection (20 ugs/kg/day, s.c.) and extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days and
* Group VI received dexamethasone (DEXA) injection (20 µg/kg/day, s.c.) and extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days.
At the end of the experiment after 14 days, the group treated with a combination of dexamethasone and beta vulgaris (100 and 300 mg/kg p.o. for 14 days) showed a significant decrease in heart rate compared to the Dexamethasone group.
According to the tested assays, the dexamethasone-treated group showed a significant elevation (p<0.05) in systolic blood pressure (SBP), and vascular reactivity changes to Catecholamine, compared to the control group.
Injection of beta vulgaris extract (100, 300 mg/kg/day, p.o.) for 14 days in dexamethasone-administered rats significantly (p<0.05) demonstrated a significant reversal of such change.
Based on the finding, researchers wrote, "The methanolic-HCl extract of Beta vulgaris has antihypertensive activity in Dexamethasone models".
In other words, betanin detected by phytochemical analysis from beta vulgaris extract protected the heart function and blood vessels through its antihypertensive properties.
Taken altogether, betanin may be considered a supplement for the prevention and treatment of hypertension, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antihypertensive activity of Beta vulgaris on dexamethasone-induced hypertension in rats by Dignesh Patel, Rupali A Patil, and Alkesh Patel. (Research Gate)
(2) High-Fat Diet Elevates Blood Pressure and Cerebrovascular Muscle Ca2+Current
Dixon W. Wilde, Kenneth D. Massey, Glenn K. Walker, Alan Vollmer, and Roger J. Grekin. (Hypertension)
Hypertension is a medical condition caused by abnormally high pressure that presses against the wall of the arteries, affecting the heart's function in pumping blood to the body.
Hypertension is a member of the cluster of metabolic syndrome that facilitates the risk of cardiovascular disease and type 2 diabetes
Epidemiologically, uncontrolled high blood pressure has been found to induce the risk of heart attack and stroke.
Most patients with high blood pressure are asymptomatic. However, the long-term elevated force of the blood against your artery walls may result in symptoms of headache, dizziness, shortness of breath, early signs of heart disease, and stroke.
According to the statistics provided by the CDC, approximately 75 million American adults (32%) have high blood pressure. In other words, 1 in every 3 American adults is affected by high blood pressure.
Believe it or not, the actual numbers of high blood pressure are substantially higher if people with the stage of prehypertension are also taken into account.
Sadly, only half of the people with high blood pressure in the US are under control.
There are 2 types of hypertension, including primary hypertension which takes years to develop, and secondary hypertension associated with other medical conditions, such as kidney and thyroid disease.
Out of many prevalent factors, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a direct implication on the onset of hypertension in American adults.
Dr.Dixon W. Wilde, the lead scientist wrote, "Dietary fat contributes to the elevation of blood pressure and increases the risk of stroke and coronary artery disease".
And, "an elevation of plasma FAs may contribute to the development of hypertension via a process involving the elevation of Ca2+ current density and alteration of channel kinetics in the vascular smooth muscle membrane".
The results strongly suggested the high-fat diet-induced elevated FAs associated with the alternation of vascular smooth muscle membrane in the initiation of hypertension.
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In finding a potential ingredient for the treatment of hypertension, researchers examined the effect of betanin against a hypertensive animal model.
The study included animals divided into six main groups with each group containing 5 animals.
* Group I received the vehicle,
* Group II received dexamethasone injection (20 µg/kg/day, s.c.) for 14 days,
* Group III received an extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days,
* Group IV received an extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days,
* Group V received dexamethasone injection (20 ugs/kg/day, s.c.) and extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days and
* Group VI received dexamethasone (DEXA) injection (20 µg/kg/day, s.c.) and extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days.
At the end of the experiment after 14 days, the group treated with a combination of dexamethasone and beta vulgaris (100 and 300 mg/kg p.o. for 14 days) showed a significant decrease in heart rate compared to the Dexamethasone group.
According to the tested assays, the dexamethasone-treated group showed a significant elevation (p<0.05) in systolic blood pressure (SBP), and vascular reactivity changes to Catecholamine, compared to the control group.
Injection of beta vulgaris extract (100, 300 mg/kg/day, p.o.) for 14 days in dexamethasone-administered rats significantly (p<0.05) demonstrated a significant reversal of such change.
Based on the finding, researchers wrote, "The methanolic-HCl extract of Beta vulgaris has antihypertensive activity in Dexamethasone models".
In other words, betanin detected by phytochemical analysis from beta vulgaris extract protected the heart function and blood vessels through its antihypertensive properties.
Taken altogether, betanin may be considered a supplement for the prevention and treatment of hypertension, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antihypertensive activity of Beta vulgaris on dexamethasone-induced hypertension in rats by Dignesh Patel, Rupali A Patil, and Alkesh Patel. (Research Gate)
(2) High-Fat Diet Elevates Blood Pressure and Cerebrovascular Muscle Ca2+Current
Dixon W. Wilde, Kenneth D. Massey, Glenn K. Walker, Alan Vollmer, and Roger J. Grekin. (Hypertension)
#Phytochemical #Betanin Inhibits #LungCancer Through Its #Antioxidant and Anti-Inflammatory Mechanisms, According to Studies
Kyle J. Norton
Antioxidants are stable atoms that inhibit oxidation induced by free radicals.
There are 2 types of antioxidants found in the human body, including
* Internally, antioxidant enzymes produced by the liver
* Externally, antioxidants are produced by the intake of antioxidants-rich food.
Free radicals, in fact, are everywhere, any atoms with oxygen molecules that have an unpaired electron on the outermost ring are considered free radicals.
Free radicals are unstable atoms. Therefore, in order to maintain stable, free radicals are ready to donate or intercept an electron from other stable atoms, leading to a chain of reaction that can not be stopped until all outermost ring electrons are paired or inhibited by antioxidants.
An unbalanced ratio of the levels of free radicals and antioxidants over the long-term can induce oxidative stress, a condition that causes protein and lipid damage and alternation of cell DNA.
In a healthy individual, antioxidants produced by the body are normally good enough to neutralize free radicals produced by the body in support of cellular metabolism and by external sources, such as the air we breathe and the foods we eat.
Diseases associated with oxidative stress including cardiovascular disease, type II diabetes, and cancer.
However, for people with a weakened immune system such as the elderly, the intake of antioxidants may be necessary.
Dr. wrote, "Oxidant-mediated tissue injury is a particular hazard to the immune system since phagocytic cells produce reactive oxygen species as part of the body's defense against infection".
And, " Although more striking effects have been observed in the elderly, there is also evidence that antioxidant nutrients can modify cell-mediated immune responses in younger individuals".
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound associated with the reduced risk of oxidative stress, researchers examined the antioxidant activity of betanin on a rat paraquat-induced acute lung injury (ALI) model.
The study included paraquat injected intraperitoneally at a single dose of 20 mg/kg body weight, and betanin (25 and 100 mg/kg/d) following the orally administered 3 days before and 2 days after paraquat administration in selected rats.
According to the results of tested assays on rats sacrificed 24 hours after the last betanin dosage, and lung tissue and bronchoalveolar lavage fluid (BALF) collected, rats treated only with paraquat showed an extensive lung injury characteristic of ALI, including increased malondialdehyde (MDA) and myeloperoxidase (MPO) levels, lung oxidative stress markers, reduced antioxidant activity and increased expression of pro-inflammatory proteins in the lung.
Rat treated with betanin attenuated all such changes, in a dose-dependent manner.
In other words, betanin ameliorated the effects of paraquat-induced ALI probably via antioxidant and anti-inflammatory mechanisms.
In order to maintain the release of betanin, researchers incorporated red beetroot (RB) powder into starch-based bio-elastomers to obtain flexible biocomposites with tunable antioxidant properties.
According to free radical assays, betanin released by the corporation demonstrated highly efficient antioxidant scavenging activity against 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS(+)) compared to the application of red beetroot (RB) powder.
More precisely, red beetroot (RB) powder incorporated into starch-based bio-elastomers is more effective in inhibiting oxidation caused by free radicals compared to red beetroot (RB) powder.
Based on the results, Dr. Tran TN, the lead scientist wrote, "Hence, as a simple but intelligent biomaterial consisting of mainly edible starch and RB powder the present bio-elastomers can be used (to provide antioxidation) in the active packaging for a variety of pharmaceutical, medical, and food applications".
Taken altogether, betanin may be considered a supplement to improve the antioxidant profile of patients, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Natural antioxidant betanin protects rats from paraquat-induced acute lung injury interstitial pneumonia by Han J1, Ma D1, Zhang M1, Yang X1, Tan D. (PubMed)
(2) Starch-based bio-elastomers functionalized with red beetroot natural antioxidant by Tran TN1, Athanassiou A2, Basit A3, Bayer IS. (PubMed)
(3) Effects of dietary antioxidants on the immune function of middle-aged adults by Hughes DA. (PubMed)
Antioxidants are stable atoms that inhibit oxidation induced by free radicals.
There are 2 types of antioxidants found in the human body, including
* Internally, antioxidant enzymes produced by the liver
* Externally, antioxidants are produced by the intake of antioxidants-rich food.
Free radicals, in fact, are everywhere, any atoms with oxygen molecules that have an unpaired electron on the outermost ring are considered free radicals.
Free radicals are unstable atoms. Therefore, in order to maintain stable, free radicals are ready to donate or intercept an electron from other stable atoms, leading to a chain of reaction that can not be stopped until all outermost ring electrons are paired or inhibited by antioxidants.
An unbalanced ratio of the levels of free radicals and antioxidants over the long-term can induce oxidative stress, a condition that causes protein and lipid damage and alternation of cell DNA.
In a healthy individual, antioxidants produced by the body are normally good enough to neutralize free radicals produced by the body in support of cellular metabolism and by external sources, such as the air we breathe and the foods we eat.
Diseases associated with oxidative stress including cardiovascular disease, type II diabetes, and cancer.
However, for people with a weakened immune system such as the elderly, the intake of antioxidants may be necessary.
Dr. wrote, "Oxidant-mediated tissue injury is a particular hazard to the immune system since phagocytic cells produce reactive oxygen species as part of the body's defense against infection".
And, " Although more striking effects have been observed in the elderly, there is also evidence that antioxidant nutrients can modify cell-mediated immune responses in younger individuals".
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound associated with the reduced risk of oxidative stress, researchers examined the antioxidant activity of betanin on a rat paraquat-induced acute lung injury (ALI) model.
The study included paraquat injected intraperitoneally at a single dose of 20 mg/kg body weight, and betanin (25 and 100 mg/kg/d) following the orally administered 3 days before and 2 days after paraquat administration in selected rats.
According to the results of tested assays on rats sacrificed 24 hours after the last betanin dosage, and lung tissue and bronchoalveolar lavage fluid (BALF) collected, rats treated only with paraquat showed an extensive lung injury characteristic of ALI, including increased malondialdehyde (MDA) and myeloperoxidase (MPO) levels, lung oxidative stress markers, reduced antioxidant activity and increased expression of pro-inflammatory proteins in the lung.
Rat treated with betanin attenuated all such changes, in a dose-dependent manner.
In other words, betanin ameliorated the effects of paraquat-induced ALI probably via antioxidant and anti-inflammatory mechanisms.
In order to maintain the release of betanin, researchers incorporated red beetroot (RB) powder into starch-based bio-elastomers to obtain flexible biocomposites with tunable antioxidant properties.
According to free radical assays, betanin released by the corporation demonstrated highly efficient antioxidant scavenging activity against 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS(+)) compared to the application of red beetroot (RB) powder.
More precisely, red beetroot (RB) powder incorporated into starch-based bio-elastomers is more effective in inhibiting oxidation caused by free radicals compared to red beetroot (RB) powder.
Based on the results, Dr. Tran TN, the lead scientist wrote, "Hence, as a simple but intelligent biomaterial consisting of mainly edible starch and RB powder the present bio-elastomers can be used (to provide antioxidation) in the active packaging for a variety of pharmaceutical, medical, and food applications".
Taken altogether, betanin may be considered a supplement to improve the antioxidant profile of patients, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Natural antioxidant betanin protects rats from paraquat-induced acute lung injury interstitial pneumonia by Han J1, Ma D1, Zhang M1, Yang X1, Tan D. (PubMed)
(2) Starch-based bio-elastomers functionalized with red beetroot natural antioxidant by Tran TN1, Athanassiou A2, Basit A3, Bayer IS. (PubMed)
(3) Effects of dietary antioxidants on the immune function of middle-aged adults by Hughes DA. (PubMed)
Serums of #BetaCarotene and #Lycopene Levels Are Associated with a Reduced Risk of #LungCancer, Reserachers Find
Kyle J. Norton
The lung is one of the vital organs in humans located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting it to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.
Lung cancer is a chronic medical condition characterized by abnormal growth of the cells in the lung's tissue.
The most common form of primary lung cancer is derived from epithelial cells.
The exact cause of lung cancer is not identified. However, epidemiologically, smoking, second smoke, exposure to certain chemicals, family history, people who have lung disease, and excessive drinking are some prevalent factors associated with lung cancer developing.
According to the statistics provided by the American Cancer Society, Lung cancer accounts for 14% of all new cancers diagnosed in the US. In 2018, there were about 234,030 new cases of lung cancer (121,680 in men and 112,350 in women). Lung cancer also causes the death of 83,550 in men and 70,500 in women in the same year.
Lung cancer can be classified into 2 major types
* Non-small cell lung cancer
Non-small cell lung cancer is the most common type of lung cancer that usually grows and spreads methodically and predictably. The most common types of Non-small cell lung cancer lung cancers include
**Squamous-cell carcinoma often is found in an outer area of the lung.
** Large-cell carcinoma is found in the center of the lung by an air tube.
** Adenocarcinoma is found in any part of the lung.
* Small cell lung cancer
Small cell lung cancer is a fast-growing type of lung cancer, that can spread to distant parts of the body in a relatively early stage. The most common types of small cell lung cancer include
* Small cell carcinoma is small, round, and resembles oats.
*Mixed small cell/large cell carcinoma is found in combining components of small cell lung carcinoma with large cell lung carcinoma.
*Combined small cell carcinoma is found in combining a component of small cell lung carcinoma with components of non-small cell lung carcinoma.
Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
In finding a potential compound for the treatment of lung cancer, researchers compared the dietary intake and serum levels of some selected carotenoids of lung cancer patients with healthy subjects.
The case-control study included 35 lung cancer patients and 33 healthy people with a daily intake of nutrients estimated by using a semiquantitative food frequency questionnaire and a 3-day 24-hour food recall questionnaire.
According to the tested analysis,
* The beta-carotene and lycopene intake of the case subjects was 96% and 195% higher in the lung participants compared to those of the control.
* Daily intake of fruits and vegetables in the cancer group was higher compared to the control group.
However, the serum concentrations of beta-carotene and lycopene were 118% and 60% higher in the control group compared to the lung cancer group.
These results suggested that there must be some unknown mechanisms associated with the reduced levels of beta-carotene and lycopene in the blood of lung cancer patients.
In other words, the intake of beta-carotene and lycopene daily reduces the risk of lung cancer in healthy individuals.
Dr. Asbaghi S, the lead scientist after taking other factors such as age, gender, smoking habits, weight, body mass index, mean daily energy intake, and mean daily fat intake into account wrote, "Despite a higher daily dietary intake of beta-carotene and lycopene by lung cancer patients, serum beta-carotene and lycopene concentrations were significantly lower than the group without cancer".
Taken altogether, carotenoids processed abundantly beta-carotene and lycopene may be considered a remedy for the prevention of lung cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Intake and Serum Level of Carotenoids in Lung Cancer Patients: A Case-Control Study by Asbaghi S1, Saedisomeolia A, Hosseini M, Honarvar NM, Khosravi A, Azargashb E. (PubMed)
(2) Blood concentrations of carotenoids and retinol and lung cancer risk: an update of the WCRF-AICR systematic review of published prospective studies by Abar L1, Vieira AR1, Aune D1,2, Stevens C1, Vingeliene S1, Navarro Rosenblatt DA1, Chan D1, Greenwood DC3, Norat T. (PubMed)
(3) Lung Cancer by Kyle J. Norton
The lung is one of the vital organs in humans located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting it to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.
Lung cancer is a chronic medical condition characterized by abnormal growth of the cells in the lung's tissue.
The most common form of primary lung cancer is derived from epithelial cells.
The exact cause of lung cancer is not identified. However, epidemiologically, smoking, second smoke, exposure to certain chemicals, family history, people who have lung disease, and excessive drinking are some prevalent factors associated with lung cancer developing.
According to the statistics provided by the American Cancer Society, Lung cancer accounts for 14% of all new cancers diagnosed in the US. In 2018, there were about 234,030 new cases of lung cancer (121,680 in men and 112,350 in women). Lung cancer also causes the death of 83,550 in men and 70,500 in women in the same year.
Lung cancer can be classified into 2 major types
* Non-small cell lung cancer
Non-small cell lung cancer is the most common type of lung cancer that usually grows and spreads methodically and predictably. The most common types of Non-small cell lung cancer lung cancers include
**Squamous-cell carcinoma often is found in an outer area of the lung.
** Large-cell carcinoma is found in the center of the lung by an air tube.
** Adenocarcinoma is found in any part of the lung.
* Small cell lung cancer
Small cell lung cancer is a fast-growing type of lung cancer, that can spread to distant parts of the body in a relatively early stage. The most common types of small cell lung cancer include
* Small cell carcinoma is small, round, and resembles oats.
*Mixed small cell/large cell carcinoma is found in combining components of small cell lung carcinoma with large cell lung carcinoma.
*Combined small cell carcinoma is found in combining a component of small cell lung carcinoma with components of non-small cell lung carcinoma.
Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
In finding a potential compound for the treatment of lung cancer, researchers compared the dietary intake and serum levels of some selected carotenoids of lung cancer patients with healthy subjects.
The case-control study included 35 lung cancer patients and 33 healthy people with a daily intake of nutrients estimated by using a semiquantitative food frequency questionnaire and a 3-day 24-hour food recall questionnaire.
According to the tested analysis,
* The beta-carotene and lycopene intake of the case subjects was 96% and 195% higher in the lung participants compared to those of the control.
* Daily intake of fruits and vegetables in the cancer group was higher compared to the control group.
However, the serum concentrations of beta-carotene and lycopene were 118% and 60% higher in the control group compared to the lung cancer group.
These results suggested that there must be some unknown mechanisms associated with the reduced levels of beta-carotene and lycopene in the blood of lung cancer patients.
In other words, the intake of beta-carotene and lycopene daily reduces the risk of lung cancer in healthy individuals.
Dr. Asbaghi S, the lead scientist after taking other factors such as age, gender, smoking habits, weight, body mass index, mean daily energy intake, and mean daily fat intake into account wrote, "Despite a higher daily dietary intake of beta-carotene and lycopene by lung cancer patients, serum beta-carotene and lycopene concentrations were significantly lower than the group without cancer".
Taken altogether, carotenoids processed abundantly beta-carotene and lycopene may be considered a remedy for the prevention of lung cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Intake and Serum Level of Carotenoids in Lung Cancer Patients: A Case-Control Study by Asbaghi S1, Saedisomeolia A, Hosseini M, Honarvar NM, Khosravi A, Azargashb E. (PubMed)
(2) Blood concentrations of carotenoids and retinol and lung cancer risk: an update of the WCRF-AICR systematic review of published prospective studies by Abar L1, Vieira AR1, Aune D1,2, Stevens C1, Vingeliene S1, Navarro Rosenblatt DA1, Chan D1, Greenwood DC3, Norat T. (PubMed)
(3) Lung Cancer by Kyle J. Norton
#Herbal Turmeric Extract Inhibits Human Papillomavirus-Positive and Negative HPV+, HPV- Cells, Through Its Cell Cycle Arrest, Researchers Find
Kyle J. Norton
Cancer is a group of chronic diseases associated with cell growth disorderly in the tissue of some specific organ. Depending on the grade and stage, most cases of cancer in the advanced stage have been found to induce a higher mortality rate compared to cancer diagnosed in the localized stage.
Head and neck cancer is a group of cancers that starts in the cell on the surface of the inner lining of the mouth, nose, throat, larynx, sinuses, or salivary glands.
Squamous cell carcinoma is cancer arising from the squamous cells found in the outer layer of skin and in the mucous membranes, which are the moist tissues that line body cavities.
Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat.
Head and neck squamous cell carcinoma (HNSCC) epidemiologically has been found to spread to the lymph nodes or lungs. More than 90% of the head and neck cancer diagnosed are squamous carcinomas.
Symptoms of head and neck cancer may include a lump or sore that does not heal, a sore throat that does not go away, trouble swallowing, or a change in the voice.
According to the statistics provided by the Western General Hospital, squamous cell cancer of the head and neck is common worldwide accounting for 4% of all cancers in the United States and 5% in the United Kingdom.
The exact causes of head and neck squamous cell carcinoma (HNSCC) are unknown. However, geographically, smoking tobacco, drinking alcohol, and long term poor diet is important to risk factors in the West compared to risk factors of chewing betel or areca nuts, smoking bidis, and taking snuff are important in the Indian subcontinent.
More importantly, the genetic preposition of genome 9p21, which may indicate the loss of a gene that suppresses tumors accounts for a total of 70% of all cases.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential ingredient for the treatment of head and neck cancer, researchers examined the effect of curcumin on head and neck squamous cell carcinoma (HNSCC) using a panel of cell lines with and without human papillomavirus (HPV+, HPV-).
According to the tested differentiation, curcumin treatment of HNSCC cell lines not only interfered with RNA of Skp2, which causes cancer tumorigenesis and radiation tolerance but also induced concomitant accumulation of p21 and p27 associated with a cell cycle arrest in HPV+, HPV- cells.
Furthermore, curcumin inhibits cell viability and induces apoptosis in a dose-dependent manner in the tested cell line with and without human papillomavirus (HPV+, HPV-).
Moreover, curcumin treatment of HPV+ and HPV- cells resulted in apoptosis via the mitochondrial pathway of apoptosis and activation of caspases that play a critical role in programmed cell death.
Additionally, the inhibition of HPV+ and HPV- cells by curcumin was also found to suppress the expression of poor prognostic markers such as XIAP, and cancer survival such as cIAP1, and cIAP2.
More importantly, co-treatment of HNSCC cells with curcumin and cisplatin potentiated inhibition of cell viability and apoptotic effects.
Based on the findings, researchers wrote in the final report, "These data suggest an important function for curcumin, acting as a suppressor of oncoprotein Skp2 in squamous cell carcinoma cells in both HPV+ and HPV- cells".
Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of HNSCC, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells by Khan AQ1, Siveen KS1, Prabhu KS1, Kuttikrishnan S1, Akhtar S1, Shaar A1, Raza A2, Mraiche F3, Dermime S2, Uddin S. (PubMed)
(2) TriCurin, a novel formulation of curcumin, epicatechin gallate, and resveratrol, inhibits the tumorigenicity of human papillomavirus-positive head and neck squamous cell carcinoma by Piao L1,2, Mukherjee S3,4, Chang Q4,5, Xie X1,2, Li H6, Castellanos MR7, Banerjee P3,4, Iqbal H1,2, Ivancic R1,2, Wang X1,2, Teknos TN1,2, Pan Q. (PubMed)
(3) Squamous cell carcinomas of the head and neck by R J Sanderson, consultant otolaryngologist and J A D Ironside, consultant clinical oncologist. (PMC)
Cancer is a group of chronic diseases associated with cell growth disorderly in the tissue of some specific organ. Depending on the grade and stage, most cases of cancer in the advanced stage have been found to induce a higher mortality rate compared to cancer diagnosed in the localized stage.
Head and neck cancer is a group of cancers that starts in the cell on the surface of the inner lining of the mouth, nose, throat, larynx, sinuses, or salivary glands.
Squamous cell carcinoma is cancer arising from the squamous cells found in the outer layer of skin and in the mucous membranes, which are the moist tissues that line body cavities.
Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat.
Head and neck squamous cell carcinoma (HNSCC) epidemiologically has been found to spread to the lymph nodes or lungs. More than 90% of the head and neck cancer diagnosed are squamous carcinomas.
Symptoms of head and neck cancer may include a lump or sore that does not heal, a sore throat that does not go away, trouble swallowing, or a change in the voice.
According to the statistics provided by the Western General Hospital, squamous cell cancer of the head and neck is common worldwide accounting for 4% of all cancers in the United States and 5% in the United Kingdom.
The exact causes of head and neck squamous cell carcinoma (HNSCC) are unknown. However, geographically, smoking tobacco, drinking alcohol, and long term poor diet is important to risk factors in the West compared to risk factors of chewing betel or areca nuts, smoking bidis, and taking snuff are important in the Indian subcontinent.
More importantly, the genetic preposition of genome 9p21, which may indicate the loss of a gene that suppresses tumors accounts for a total of 70% of all cases.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential ingredient for the treatment of head and neck cancer, researchers examined the effect of curcumin on head and neck squamous cell carcinoma (HNSCC) using a panel of cell lines with and without human papillomavirus (HPV+, HPV-).
According to the tested differentiation, curcumin treatment of HNSCC cell lines not only interfered with RNA of Skp2, which causes cancer tumorigenesis and radiation tolerance but also induced concomitant accumulation of p21 and p27 associated with a cell cycle arrest in HPV+, HPV- cells.
Furthermore, curcumin inhibits cell viability and induces apoptosis in a dose-dependent manner in the tested cell line with and without human papillomavirus (HPV+, HPV-).
Moreover, curcumin treatment of HPV+ and HPV- cells resulted in apoptosis via the mitochondrial pathway of apoptosis and activation of caspases that play a critical role in programmed cell death.
Additionally, the inhibition of HPV+ and HPV- cells by curcumin was also found to suppress the expression of poor prognostic markers such as XIAP, and cancer survival such as cIAP1, and cIAP2.
More importantly, co-treatment of HNSCC cells with curcumin and cisplatin potentiated inhibition of cell viability and apoptotic effects.
Based on the findings, researchers wrote in the final report, "These data suggest an important function for curcumin, acting as a suppressor of oncoprotein Skp2 in squamous cell carcinoma cells in both HPV+ and HPV- cells".
Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of HNSCC, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells by Khan AQ1, Siveen KS1, Prabhu KS1, Kuttikrishnan S1, Akhtar S1, Shaar A1, Raza A2, Mraiche F3, Dermime S2, Uddin S. (PubMed)
(2) TriCurin, a novel formulation of curcumin, epicatechin gallate, and resveratrol, inhibits the tumorigenicity of human papillomavirus-positive head and neck squamous cell carcinoma by Piao L1,2, Mukherjee S3,4, Chang Q4,5, Xie X1,2, Li H6, Castellanos MR7, Banerjee P3,4, Iqbal H1,2, Ivancic R1,2, Wang X1,2, Teknos TN1,2, Pan Q. (PubMed)
(3) Squamous cell carcinomas of the head and neck by R J Sanderson, consultant otolaryngologist and J A D Ironside, consultant clinical oncologist. (PMC)
#Green Peas Extract and Its Phytochemical Lectin Exert Potential Chemopreventive Activity, Researchers Say
Kyle J. Norton
Cancer is a group of cell-mutated diseases caused by the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of an organ. At early, most people with cancer are asymptomatic.
At the later stage, due to the size and the tumor, patients may experience general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort, and loss of appetite, and localized symptoms such as severe pain and bleeding.
The exact causes of cancer are not identified. However, the most prevalent factors associated with the cancer onset include age, family history, long-term exposure to certain cancer-induced chemicals, use of tobacco and excessive alcohol drinking,..... the list goes on and on, depending on the type of cancer.
Some researchers suggested that the most common risk factor that causes cancer in the Western world may be associated with widespread obesity.
Dr. Karen Basen-Engquist, in the evaluation of the obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".
And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".
The findings strongly indicated the risk of cancer is increased substantially in obese.
Green peas are a species of Pisum Sativum belonging to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalayan Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.
In finding a potent ingredient for the treatment of cancer, researchers investigated the impact of green pea (GP) extracts anti-DNA alternative activity.
According to the studies,
* The extracts of P. sativum have been found to be pharmacologically active inducing anticancer effects.
* Compared to the effect of Bowman-Birk trypsin-chymotrypsin inhibitor, a potential cancer chemopreventive agent, with the protease inhibitors, rTl1B and rTl2B, P. sativum seed showed similar significant activity.
* In human colorectal adenocarcinoma HT-29, P. sativum extracted lectins from Egypt exhibited antiproliferative properties to liver cancer cell line.
* In MCF-7 (breast), HepG-2 (liver), HEP-2 (larynx), and HCT-116 (colon). An extracted lectin from the leaves and buds of P. sativum demonstrated cytotoxic properties.
* Recently, the seed extracts also showed cytotoxic effects on LS174 (colon), MDA-MB-453 (breast), A594 (lung), and K562 (blood) cell lines.
Taken together, green peas may be considered a functional food for the prevention of cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Pea, Pisum sativum, and Its Anticancer Activity by Runchana Rungruangmaitree and Wannee Jiraungkoorskul. (PMC)
Cancer is a group of cell-mutated diseases caused by the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of an organ. At early, most people with cancer are asymptomatic.
At the later stage, due to the size and the tumor, patients may experience general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort, and loss of appetite, and localized symptoms such as severe pain and bleeding.
The exact causes of cancer are not identified. However, the most prevalent factors associated with the cancer onset include age, family history, long-term exposure to certain cancer-induced chemicals, use of tobacco and excessive alcohol drinking,..... the list goes on and on, depending on the type of cancer.
Some researchers suggested that the most common risk factor that causes cancer in the Western world may be associated with widespread obesity.
Dr. Karen Basen-Engquist, in the evaluation of the obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".
And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".
The findings strongly indicated the risk of cancer is increased substantially in obese.
Green peas are a species of Pisum Sativum belonging to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalayan Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.
In finding a potent ingredient for the treatment of cancer, researchers investigated the impact of green pea (GP) extracts anti-DNA alternative activity.
According to the studies,
* The extracts of P. sativum have been found to be pharmacologically active inducing anticancer effects.
* Compared to the effect of Bowman-Birk trypsin-chymotrypsin inhibitor, a potential cancer chemopreventive agent, with the protease inhibitors, rTl1B and rTl2B, P. sativum seed showed similar significant activity.
* In human colorectal adenocarcinoma HT-29, P. sativum extracted lectins from Egypt exhibited antiproliferative properties to liver cancer cell line.
* In MCF-7 (breast), HepG-2 (liver), HEP-2 (larynx), and HCT-116 (colon). An extracted lectin from the leaves and buds of P. sativum demonstrated cytotoxic properties.
* Recently, the seed extracts also showed cytotoxic effects on LS174 (colon), MDA-MB-453 (breast), A594 (lung), and K562 (blood) cell lines.
Taken together, green peas may be considered a functional food for the prevention of cancer, pending the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Pea, Pisum sativum, and Its Anticancer Activity by Runchana Rungruangmaitree and Wannee Jiraungkoorskul. (PMC)
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