#Intake of RAW Fruits and Vegetables Regularly are Associated with a Reduced Risk of #PancreaticCancer, Researchers Suggest

Kyle J. Norton

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, the pancreas aids the digestive system in breaking down carbohydrates, proteins, and lipids.
Traditional Chinese medicine suggests that the pancreas is a vital organ responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our bodies.

Pancreatic cancer is a chronic condition characterized by cell growth irregularly in the tissues of the pancreas.


At the early stage, patients with pancreatic cancer may be asymptomatic. However, at the later stage, besides the common symptoms shared by all types of cancer such as unintended weight loss, loss of appetite, fatigue, and gastrointestinal discomforts, patients with the condition may also experience localized symptoms such as internal bleeding and severe pain due to the oversize tumor which suppresses the nerve cells and blood vessels.

According to statistics, every year, approximately, over 55,000 adults in the United States are diagnosed with pancreatic cancer, accounting for 3% of all cancers and 7% of all cancer deaths.

The survival rate of pancreatic cancer even if diagnosed early is very low compared to other types of cancer. The 5-year survival rate for stage IA pancreatic cancer is only14%.

Researchers do not know what causes pancreatic cancer. Scientists do not know the exact causes of pancreatic cancers, but they do know several risk factors that can make a person more likely to get the disease, including the genetic and acquired genetic mutation of p16 and TP53 and KRAS, BRAF, and DPC4 (SMAD4).

Other prevalent risk factors, including long-term use of tobacco, exposure to certain chemicals, overweight, and obesity, and unpreventable risk factors of family history, gender, the increase of age, and ethnicity are associated with the early onset of pancreatic cancer.

Researchers at the Johns Hopkins Medical Center suggested an unhealthy diet high in meats, cholesterol, fried foods, and nitrosamines may increase risk, while diets high in fruits and vegetables reduce the risk of pancreatic cancer.

However, most people with some of the above risk factors do not get the disease.

In finding a potent ingredient for the treatment of diseases associated with abnormal cell growth, researchers investigated the consumption of raw fruits and vegetables' effects on pancreatic cancer.

According to the dietary habits and medical history variables in a prospective study of fatal pancreas cancer among 34,000 California Seventh-day Adventists between 1976 and 1983. Forty deaths from pancreas cancer occurred during the follow-up period,

* Compared to all US whites, Adventists experienced a decreased risk of pancreas cancer death (standardized mortality ratio [SMR] = 72 for men; 90 for women),

* Furthermore, increasing consumption of vegetarian protein products, beans, lentils, and peas, as well as dried fruit, was associated with highly significant protective relationships to pancreas cancer risk compared to increased risk in increasing meat, egg, and coffee consumption.

In other words, regular consumption of raw fruits and vegetables exerted protective relationships associated with a protease-inhibitor content that decreases the risk of pancreas cancer in high-risk patients.

Taken together, fruits and vegetables may be considered a functional food for the prevention of pancreas cancer, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary habits and past medical history as related to fatal pancreas cancer risk among Adventists by Mills PK1, Beeson WL, Abbey DE, Fraser GE, Phillips RL.(PubMed)

#Ethanolic #Extract Found in #CynometraCauliflora Leaves Inhibits Parameters Associated with the Onset of Obesity, Scientists Say

Kyle J. Norton

Obesity is a chronic and medical condition caused by excess body fat accumulated to some extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.

According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.

Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.


In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.

According to the BMI index, a person is considered overweight, if he/she has a BMI between 25 to 29.9 kg/m2. A BMI of 30 kg/m2 or more is an indication of obesity.

In other words, obesity is a progressive chronic disease characterized by abnormal fat accumulation in the body tissues that may impair health.

Similar to other chronic medical conditions including diabetes, cardiovascular disease or high blood pressure, obesity has recently become a serious health problem in the US as nearly 35% of Americans are obese accompanied by a similar percentage of overweight adults.

Obesity and overweight in the U.S. economy have eclipsed $1.7 trillion, equivalent to 9.3 percent of the nation's gross domestic product, according to a new overweight report on chronic diseases.

Dr. Maximilian Tremmel, the lead scientist in a systematic literature review of the economic burden of obesity, wrote, " almost half of the world’s adult population will be overweight or obese by 2030 if the prevalence continues on the current trend [6] and consequently also the costs attributable to obesity will increase".

And, "A useful example for rapidly rising costs attributable to obesity from these selected studies are the two mentioned studies from Germany [44,46]. The results of the two papers together show that total societal costs in Germany due to obesity have increased from €9.8 million to €12.2 million between 2002 and 2008. Therefore, public health interventions should focus on the prevention of obesity as soon as possible, ideally at a young age".

Cynometra cauliflora is a species of the genus Cynometra, native to Malaysia, and found mainly in northern Peninsular Malaysia.

In finding a potential phytochemical for the prevention and treatment of chronic diseases, researchers examined the anti-obesity and lipid-lowering effects of ethanolic extract of C. cauliflora leaves and its major compound (vitexin) in C57BL/6 obese mice induced by a high-fat diet (HFD).

The study included male C57BL/6 mice induced obesity by feeding with HFD (60% fat) for 16 weeks followed by the treatment that starts during the last 8 weeks of HFD feeding with C. cauliflora leaf extract at 200 and 400 mg/kg/day, orlistat (10 mg/kg) and vitexin (10 mg/kg).

According to the chemical analysis,
* The oral administration of C. cauliflora (400 and 200 mg/kg) and vitexin significantly reduced body weight, adipose tissue and liver weight, and lipid accumulation in the liver compared to the control HFD group.

* Both doses of C. cauliflora also significantly (P ≤ 0.05) decreased serum triglyceride, LDL, lipase, IL-6, peptide YY, resistin levels, hyperglycemia, hyperinsulinemia, and hyperleptinemia compared to the control HFD group.

* C. cauliflora significantly up-regulated the expression of adiponectin, Glut4, Mtor, IRS-1 and InsR genes associated with the sustaining weight loss and significantly decreased the expression of Lepr in white adipose tissue involved in stimulating weight gain.

Based on the findings, researchers said, "This study shows interesting outcomes of C. cauliflora against HFD-induced obesity and associated metabolic abnormalities".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of bacterial infectious diseases, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cynometra cauliflora Linn. Attenuates metabolic abnormalities in high-fat diet-induced obese mice by Seyedan A1, Mohamed Z2, Alshagga MA3, Koosha S4, Alshawsh MA. (PubMed)
(2) Economic Burden of Obesity: A Systematic Literature Review by Maximilian Tremmel,1,* Ulf-G. Gerdtham,2,3,4 Peter M. Nilsson,5 and Sanjib Saha. (PMC)

#Betacyanins Process a Strong #Antioxidant Capacity According to Studies

Kyle J. Norton

Oxidative stress is a medical condition caused by the unbalanced ratio of the levels of free radical and antioxidant enzymes produced by the host.
In fact, free radicals exist everywhere including the airs we breathe, the thing we eat and the environment we contact, particularly, cell metabolism in the body.

Epidemiologically, overexpression of free radicals has been found to induce damage to the cell, lipid, proteins, and alternation of cell DNA, leading to chronic diseases, such as cardiovascular diseases, diabetes, and particularly, cancer.

Other diseases such as hypertension, dyslipidemia, peripheral artery disease, metabolic syndrome, diabetes, and obesity are also found in patients with oxidative stress.

In spite of free radicals' harmful effects, one must understand that cellular oxygen species (ROS), are necessary with a moderate amount to protect our body in the mediation of antimicrobial infection, detoxification of potentially toxic compounds, and elimination of cancerous and other life-threatening cells through cytotoxicity.

Free radicals are unstable atoms with an unpair of electrons on the outer ring of molecules. Therefore, in order for them to become stable, they constantly seek to donate or intercept the electron from other stable atoms, leading to a chain reaction that can not be stopped until all unpaired electrons are paired or inhibited by antioxidants.
Antioxidants are stable molecules that inhibit free radicals.

Free radicals such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, myeloperoxidase, superoxide dismutase, and glutathione peroxidase and antioxidants such as glutathione peroxidase, catalase, and superoxide dismutase (SOD) also act on specific oxidative pathways involving both pro-oxidant and antioxidant enzymes to maintain the healthy ratio in the body.


Normally, in a healthy individual, antioxidant enzymes produced by the liver are more than enough to counter levels of free radicals in the body. However, for people with weakened immune systems intake of dietary antioxidants or antioxidant supplements may be necessary.

Dr. Pignatelli P. the lead scientist in the investigation of the relationship between oxidative stress and antioxidants in CVD wrote, " 1) the most relevant enzyme systems involved in the formation and detoxification of ROS, 2) the relationship between oxidative stress and cardiovascular risk, and 3) therapeutic implications to modulate oxidative stress".

In other words, by understanding the interaction of free radicals and antioxidant, diseases associated with oxidative stress may be preventable.

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a potential compound for the treatment of diseases associated with oxidative stress, researchers assessed the antioxidant capacity of betacyanins as indole-derived plant pigments, such as betanin, phyllocactin, and betanidin.

According to the test from the peroxyl radical generating system, betacyanins exerted a significant peroxyl radical scavenging capacity at a dose-dependent in the low concentration range (25-100 nM).

In chemical analysis, betanidin, betanin, and phyllocactin demonstrated antioxidant capacity at the order of 10.70, 3.31, and 2.83 mol-TEA/mol-compound respectively.

The IC₅₀ values (μM) of nitrogen radical scavenging activity of betanin, phyllocactin, and betanidin.was 24.48, 17.51, and 6.81, respectively.

In other words, betanidin was the strongest antioxdant that exerted radical scavenging activity compared to those of betanin, and phyllocactin.

Furthermore, the expression of free radical NO was reduced by the administration of betacyanin in the low concentration range of 2.5-20 μM.


Based on the results, researchers said, "These results indicated that betacyanins have a strong antioxidant capacity, particularly betanidin with a catechol group had higher activity than those of the glycoside of betacyanins".

And, "This study demonstrated that the betacyanins will be useful as natural pigments to provide defense against oxidative stress".

Taken together, betacyanins may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Betacyanins from Portulaca oleracea L. ameliorate cognition deficits and attenuate oxidative induced by D-galactose in the brains of senescent mice by Chang-Quan Wang, and Gui-Qin Yang. (Research Gate)
(2) Antioxidant capacity of betacyanins as radical scavengers for peroxyl radical and nitric oxide by Taira J1, Tsuchida E2, Katoh MC2, Uehara M2, Ogi T. (PubMed)
(3) Oxidative stress and cardiovascular disease: new insights by Pignatelli P1, Menichelli D, Pastori D, Violi F. (PubMed)

#Cranberry, a Promising Gingipain and Periodontitis inhibitor, Researchers Find

Kyle J. Norton


Periodontitis is a serious case of gingivitis associated with gum infection that damages the soft tissue and destroys the bone that supports your teeth as a result of long-term poor oral hygiene
Periodontitis is preventable if the progression of gingivitis stages is stopped


Gingivitis is a common and mild form of periodontal disease caused by inflammation of the gingiva, leading to symptoms of irritation, redness, and swelling of the gum that lines the base of the teeth.

Gingivitis dental plaques formed around the base of the teeth are sticky biofilms of bacteria associated with the interaction of the food intake and bacteria in the mouth. Over time, if untreated, the condition can lead to periodontitis and advanced periodontitis.

At this early stage, the bone and connective tissue that hold the teeth in place are not yet affected. The problems can be reversed by more frequent and proper brushing and flossing.

Epidemiologically, risk factors that induce the onset of gingivitis are smoking or chewing tobacco. diabetes and long-term use of certain medications including oral contraceptives, steroids, anticonvulsants, and calcium channel blockers.

Some people under the treatment of chemotherapy may also experience symptoms of gingivitis.

The Colgate Professional the examined the symptoms and advised that if you have experienced some of the symptoms that do not heal themselves in a short time, such as puffy or swollen, or tender, bleeding during brushing or flossing,... and constant bad breath or a bad taste in your mouth, you may have gingivitis.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of periodontitis, researchers examined the effect of cranberry and rice extracts as a potent gingipain inhibitor.

Based on the tested analysis, cranberry and rice extracts interfere with gingipain activity that causes the slowing down the progression of adult periodontitis.

Furthermore, the extracts prevented the growth and biofilm formation of periodontal pathogens and induced the onset of periodontitis.

Moreover, the extracts also inhibited a broad spectrum of host proteases in the induction of undesirable side effects

As of today, the ideal gingipain inhibitor has yet to be discovered, however, cranberry and rice extracts may be a promising gingipain inhibitor compared to gingipain N-terminal pro domains, synthetic compounds, antibiotics, antiseptics, antibodies, and bacteria which may induce undesirable side effects

The results strongly suggested that cranberry promotes oral health by inhibiting the onset and progression of periodontitis through its anti-bacterial activity


Taken together, cranberry may be considered a remedy for the prevention and treatment of periodontitis, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases by Olsen I1, Potempa J. (PubMed)

#Phytochemical #Beetroot Extract Normalizes Your High Blood Pressure Induced by Dexamethasone, Researchers Say

Kyle J. Norton

Hypertension is a medical condition caused by abnormally high pressure that presses against the wall of the arteries, affecting the heart's function in pumping blood to the body.

Hypertension is a member of the cluster of metabolic syndrome that facilitates the risk of cardiovascular disease and type 2 diabetes

Epidemiologically, uncontrolled high blood pressure has been found to induce the risk of heart attack and stroke.

Most patients with high blood pressure are asymptomatic. However, the long-term elevated force of the blood against your artery walls may result in symptoms of headache, dizziness, shortness of breath, early signs of heart disease, and stroke.


According to the statistics provided by the CDC, approximately 75 million American adults (32%) have high blood pressure. In other words, 1 in every 3 American adults is affected by high blood pressure.


Believe it or not, the actual numbers of high blood pressure are substantially higher if people with the stage of prehypertension are also taken into account.


Sadly, only half of the people with high blood pressure in the US are under control.

There are 2 types of hypertension, including primary hypertension which takes years to develop, and secondary hypertension associated with other medical conditions, such as kidney and thyroid disease.


Out of many prevalent factors, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a direct implication on the onset of hypertension in American adults.

Dr.Dixon W. Wilde, the lead scientist wrote, "Dietary fat contributes to the elevation of blood pressure and increases the risk of stroke and coronary artery disease".


And, "an elevation of plasma FAs may contribute to the development of hypertension via a process involving the elevation of Ca2+ current density and alteration of channel kinetics in the vascular smooth muscle membrane".

The results strongly suggested the high-fat diet-induced elevated FAs associated with the alternation of vascular smooth muscle membrane in the initiation of hypertension.


Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

In finding a potential ingredient for the treatment of hypertension, researchers examined the effect of betanin against a hypertensive animal model.

The study included animals divided into six main groups with each group containing 5 animals.

* Group I received the vehicle,

* Group II received dexamethasone injection (20 µg/kg/day, s.c.) for 14 days,

* Group III received an extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days,

* Group IV received an extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days,

* Group V received dexamethasone injection (20 ugs/kg/day, s.c.) and extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days and

* Group VI received dexamethasone (DEXA) injection (20 µg/kg/day, s.c.) and extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days.

At the end of the experiment after 14 days, the group treated with a combination of dexamethasone and beta vulgaris (100 and 300 mg/kg p.o. for 14 days) showed a significant decrease in heart rate compared to the Dexamethasone group.

According to the tested assays, the dexamethasone-treated group showed a significant elevation (p<0.05) in systolic blood pressure (SBP), and vascular reactivity changes to Catecholamine, compared to the control group.


Injection of beta vulgaris extract (100, 300 mg/kg/day, p.o.) for 14 days in dexamethasone-administered rats significantly (p<0.05) demonstrated a significant reversal of such change.

Based on the finding, researchers wrote, "The methanolic-HCl extract of Beta vulgaris has antihypertensive activity in Dexamethasone models".


In other words, betanin detected by phytochemical analysis from beta vulgaris extract protected the heart function and blood vessels through its antihypertensive properties.

Taken altogether, betanin may be considered a supplement for the prevention and treatment of hypertension, pending the confirmation of a larger sample size and multicenter human study.

Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihypertensive activity of Beta vulgaris on dexamethasone-induced hypertension in rats by Dignesh Patel, Rupali A Patil, and Alkesh Patel. (Research Gate)
(2) High-Fat Diet Elevates Blood Pressure and Cerebrovascular Muscle Ca2+Current
Dixon W. Wilde, Kenneth D. Massey, Glenn K. Walker, Alan Vollmer, and Roger J. Grekin. (Hypertension)

#Phytochemical #Betanin Inhibits #LungCancer Through Its #Antioxidant and Anti-Inflammatory Mechanisms, According to Studies

Kyle J. Norton

Antioxidants are stable atoms that inhibit oxidation induced by free radicals.
There are 2 types of antioxidants found in the human body, including
* Internally, antioxidant enzymes produced by the liver

* Externally, antioxidants are produced by the intake of antioxidants-rich food.

Free radicals, in fact, are everywhere, any atoms with oxygen molecules that have an unpaired electron on the outermost ring are considered free radicals.

Free radicals are unstable atoms. Therefore, in order to maintain stable, free radicals are ready to donate or intercept an electron from other stable atoms, leading to a chain of reaction that can not be stopped until all outermost ring electrons are paired or inhibited by antioxidants.

An unbalanced ratio of the levels of free radicals and antioxidants over the long-term can induce oxidative stress, a condition that causes protein and lipid damage and alternation of cell DNA.

In a healthy individual, antioxidants produced by the body are normally good enough to neutralize free radicals produced by the body in support of cellular metabolism and by external sources, such as the air we breathe and the foods we eat.

Diseases associated with oxidative stress including cardiovascular disease, type II diabetes, and cancer.


However, for people with a weakened immune system such as the elderly, the intake of antioxidants may be necessary.

Dr. wrote, "Oxidant-mediated tissue injury is a particular hazard to the immune system since phagocytic cells produce reactive oxygen species as part of the body's defense against infection".

And, " Although more striking effects have been observed in the elderly, there is also evidence that antioxidant nutrients can modify cell-mediated immune responses in younger individuals".

Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a potential compound associated with the reduced risk of oxidative stress, researchers examined the antioxidant activity of betanin on a rat paraquat-induced acute lung injury (ALI) model.

The study included paraquat injected intraperitoneally at a single dose of 20 mg/kg body weight, and betanin (25 and 100 mg/kg/d) following the orally administered 3 days before and 2 days after paraquat administration in selected rats.

According to the results of tested assays on rats sacrificed 24 hours after the last betanin dosage, and lung tissue and bronchoalveolar lavage fluid (BALF) collected, rats treated only with paraquat showed an extensive lung injury characteristic of ALI, including increased malondialdehyde (MDA) and myeloperoxidase (MPO) levels, lung oxidative stress markers, reduced antioxidant activity and increased expression of pro-inflammatory proteins in the lung.

Rat treated with betanin attenuated all such changes, in a dose-dependent manner.

In other words, betanin ameliorated the effects of paraquat-induced ALI probably via antioxidant and anti-inflammatory mechanisms.

In order to maintain the release of betanin, researchers incorporated red beetroot (RB) powder into starch-based bio-elastomers to obtain flexible biocomposites with tunable antioxidant properties.


According to free radical assays, betanin released by the corporation demonstrated highly efficient antioxidant scavenging activity against 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS(+)) compared to the application of red beetroot (RB) powder.

More precisely, red beetroot (RB) powder incorporated into starch-based bio-elastomers is more effective in inhibiting oxidation caused by free radicals compared to red beetroot (RB) powder.


Based on the results, Dr. Tran TN, the lead scientist wrote, "Hence, as a simple but intelligent biomaterial consisting of mainly edible starch and RB powder the present bio-elastomers can be used (to provide antioxidation) in the active packaging for a variety of pharmaceutical, medical, and food applications".
Taken altogether, betanin may be considered a supplement to improve the antioxidant profile of patients, pending the confirmation of a larger sample size and multicenter human study.

Intake of betanin in supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Natural antioxidant betanin protects rats from paraquat-induced acute lung injury interstitial pneumonia by Han J1, Ma D1, Zhang M1, Yang X1, Tan D. (PubMed)
(2) Starch-based bio-elastomers functionalized with red beetroot natural antioxidant by Tran TN1, Athanassiou A2, Basit A3, Bayer IS. (PubMed)
(3) Effects of dietary antioxidants on the immune function of middle-aged adults by Hughes DA. (PubMed)

Serums of #BetaCarotene and #Lycopene Levels Are Associated with a Reduced Risk of #LungCancer, Reserachers Find

Kyle J. Norton

The lung is one of the vital organs in humans located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting it to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.
Lung cancer is a chronic medical condition characterized by abnormal growth of the cells in the lung's tissue.

The most common form of primary lung cancer is derived from epithelial cells.

The exact cause of lung cancer is not identified. However, epidemiologically, smoking, second smoke, exposure to certain chemicals, family history, people who have lung disease, and excessive drinking are some prevalent factors associated with lung cancer developing.


According to the statistics provided by the American Cancer Society, Lung cancer accounts for 14% of all new cancers diagnosed in the US. In 2018, there were about 234,030 new cases of lung cancer (121,680 in men and 112,350 in women). Lung cancer also causes the death of 83,550 in men and 70,500 in women in the same year.

Lung cancer can be classified into 2 major types
* Non-small cell lung cancer
Non-small cell lung cancer is the most common type of lung cancer that usually grows and spreads methodically and predictably. The most common types of Non-small cell lung cancer lung cancers include
**Squamous-cell carcinoma often is found in an outer area of the lung.

** Large-cell carcinoma is found in the center of the lung by an air tube.

** Adenocarcinoma is found in any part of the lung.

* Small cell lung cancer
Small cell lung cancer is a fast-growing type of lung cancer, that can spread to distant parts of the body in a relatively early stage. The most common types of small cell lung cancer include
* Small cell carcinoma is small, round, and resembles oats.

*Mixed small cell/large cell carcinoma is found in combining components of small cell lung carcinoma with large cell lung carcinoma.

*Combined small cell carcinoma is found in combining a component of small cell lung carcinoma with components of non-small cell lung carcinoma.

Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.

In finding a potential compound for the treatment of lung cancer, researchers compared the dietary intake and serum levels of some selected carotenoids of lung cancer patients with healthy subjects.

The case-control study included 35 lung cancer patients and 33 healthy people with a daily intake of nutrients estimated by using a semiquantitative food frequency questionnaire and a 3-day 24-hour food recall questionnaire.

According to the tested analysis,
* The beta-carotene and lycopene intake of the case subjects was 96% and 195% higher in the lung participants compared to those of the control.
* Daily intake of fruits and vegetables in the cancer group was higher compared to the control group.


However, the serum concentrations of beta-carotene and lycopene were 118% and 60% higher in the control group compared to the lung cancer group.

These results suggested that there must be some unknown mechanisms associated with the reduced levels of beta-carotene and lycopene in the blood of lung cancer patients.

In other words, the intake of beta-carotene and lycopene daily reduces the risk of lung cancer in healthy individuals.


Dr. Asbaghi S, the lead scientist after taking other factors such as age, gender, smoking habits, weight, body mass index, mean daily energy intake, and mean daily fat intake into account wrote, "Despite a higher daily dietary intake of beta-carotene and lycopene by lung cancer patients, serum beta-carotene and lycopene concentrations were significantly lower than the group without cancer".


Taken altogether, carotenoids processed abundantly beta-carotene and lycopene may be considered a remedy for the prevention of lung cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of carotenoids in supplements should be taken with extreme care to prevent overdose acute liver toxicity.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Intake and Serum Level of Carotenoids in Lung Cancer Patients: A Case-Control Study by Asbaghi S1, Saedisomeolia A, Hosseini M, Honarvar NM, Khosravi A, Azargashb E. (PubMed)
(2) Blood concentrations of carotenoids and retinol and lung cancer risk: an update of the WCRF-AICR systematic review of published prospective studies by Abar L1, Vieira AR1, Aune D1,2, Stevens C1, Vingeliene S1, Navarro Rosenblatt DA1, Chan D1, Greenwood DC3, Norat T. (PubMed)
(3) Lung Cancer by Kyle J. Norton