Kyle J. Norton
The liver is the largest internal organ that not only filters the blood from the digestive system before passing it to other parts of the body but also plays a critical role in the production of cholesterol, a waxy substance that aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.
Hepatic stress is a condition in which the function of the liver is partly reduced. Hepatic stress can be observed by the levels of liver stress-makers.
Liver function tests (LFTs or LFs) are used to measure the levels of liver transaminases aspartate transaminase (AST) and alanine transaminase (ALT) in patients with liver injury, particularly, in a patient with some degree of intact liver function.
Abnormal high levels of transaminases aspartate transaminase (AST) and alanine transaminase (ALT) are early indications of liver damage or injury.
Oxidative stress in the liver caused by a toxic substance such as an overdose of the supplement has been found to constitute most cases of acute liver damage.
Lauren Cooper, the author of the examines the toxic effects of an overdose of green tea extract and bodybuilding pills wrote, "Many herbal remedies and dietary supplements can also harm the liver, including some that you can easily buy online or over-the-counter in drug or health food stores".
And, "Researchers looked at cases of liver damage reported to the Drug-Induced Liver Injury Network, a program funded by the National Institutes of Health. Roughly 700 cases of liver damage were reported to the program during the period of the study; 130 of those cases were linked to dietary supplements".
The results strongly suggested although green tea extract is considered a functional supplement for the treatment of various diseases, overdose and abusive use of such supplements also have a negative impact on human health, particularly liver health.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential compound for the improvement of liver functioning, researchers examined the effect of Curcuma longa L. (CLL) rhizome on hepatic dysfunction.
On acute carbon tetrachloride (CCl4)-induced liver stress rats, researchers compared the activity of CLL extract administered once a day for 3 days at three dose levels (100, 200, and 300 mg/kg/day) and curcumin administered once a day at the 200 mg/kg/day.
Before treatment, CCl4 rats showed a significant induced increased serum AST and ALT levels by 2.1- and 1.2-fold, respectively, compared with the control.
CLL- and curcumin-treated rats inhibited the levels of AST but not ALT elevation induced by CCl4.
Furthermore, according to the tested assays, the peroxidation of membrane lipids in the liver was significantly prevented by CLL (100, 200, and 300 mg/kg/day) on liver tissues.
Moreover, both CLL extract and curcumin exhibited significant protection against liver injury by improving the levels of hepatic antioxidant enzymes such as superoxide dismutase and glutathione peroxidase, and glutathione against free radicals expression in the CCl4 treated rats.
More precisely, both CLL extract and curcumin protected the liver cells against the onset of liver cellular stress by reducing the liver damage markers and inhibiting the liver oxidative stress via increased production of liver antioxidant enzymes.
Dr. Lee GH, the lead scientist said, "Our data suggested that CLL extract and curcumin protect the liver from acute CCl4-induced injury in a rodent model by suppressing hepatic oxidative stress. Therefore, CLL extract and curcumin are potential therapeutic antioxidant agents against acute hepatotoxicity".
Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the improvement of liver functioning against liver damage, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin and Curcuma longa L. extract ameliorates lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress by Lee HY1, Kim SW2, Lee GH1, Choi MK1, Chung HW1, Lee YC3, Kim HR4, Kwon HJ5, Chae HJ. (PubMed)
(2) Protective effect of Curcuma longa L. extracts on CCl4-induced acute hepatic stress by Lee GH1, Lee HY1, Choi MK1, Chung HW1, Kim SW2,3, Chae HJ. (PubMed)
(3) Liver Damage From Supplements Is on the Rise. Green tea extract and bodybuilding pills pose a particular risk, study finds By Lauren Cooper. (CR)
Tuesday, 5 September 2023
#Ginger Intake Orally Rduces Pain and Disability of Patients with #Osteoarthritis, According to Studies
Kyle J. Norton
Ginger may have a potential and positive effect in ameliorating the symptoms of pain and complications of reduced quality of life in patients with osteoarthritis, some scientists suggested.
Osteoarthritis (OA) is a chronic condition a type of joint disease characterized by the breaking down of joint cartilage and underlying bone due to the “wear and tear” of joints over time.
Some researchers suggested that OA is a degenerative disease characterized by “low-grade inflammation” in the cartilage and synovium, affecting the joint structure and progressive deterioration of cartilage.
According to the statistics from the NIH, osteoarthritis (OA) is the most common joint disorder in the US. Among adults, 60 years of age or older the prevalence of symptomatic knee and sadly OA affects approximately 10% of men and 13% of women.
Epidemiological strongly suggest that obesity and overweight which have a strong impact on weight-bearing joints, the genetic preposition of a patient can make such a patient more susceptible to the disease compared to others who do not, people with a joint injury that did heal properly at a younger age and people with occupations that require standing for long periods of time, repetitive bending, heavy lifting or other movements and the increase in age are associated to the increased risk of the onset of the disease.
The most common symptoms of osteoarthritis are joint pain and stiffness.
Dr. Giuseppe Musumeci, the lead author in the study "Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression" suggested that besides the risk factors mentioned above, dietary factors also play an important role in the onset of the disease.
In the dietary aspect in the induction of OA, the research team wrote, "This diet (The Western diet) is mainly constituted by preservative and harmful substances, such as animal fat and glucose excessive concentration and lack of nutritional factors, such as vitamins and nutrient minerals essential for our body. Moreover, bad dietary habits may predispose people to obesity, which is responsible for both metabolic destroying processes affecting the cartilage and overload of the joints, especially hips and knees".
And, " Quantity and quality of nutrient intake. Low intake of vitamin D and vitamin C is a possible risk factor for knee OA, while certain food groups, such as milk and dairy products, meat, and poultry are beneficial for knee OA. Thus we could affirm that nutritional imbalance, combined with endocrine abnormalities, may be involved in the pathogenesis of OA".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to reaffirm the traditional use of ginger for the treatment of osteoarthritis, a joint review led by the Copenhagen University Hospital, Bispebjerg, and Frederiksberg was conducted to assess the clinical efficacy and safety of oral ginger for the symptomatic treatment of osteoarthritis (OA).
The study was carried out by searching the randomized controlled trials (RCTs) comparing oral ginger treatment with placebo in OA patients aged >18 years satisfied the predetermined guidelines and criteria, including the outcomes of the reduction in pain and disability.
Out of 122 retrieved references, 117 were discarded, and only 5 five trials (593 patients) were selected for meta-analyses.
All 5 remaining studies suggested that ginger intake scored a statistically significant pain reduction.
Furthermore, the application of ginger in subjects with osteoarthritis demonstrates a statistically significant reduction in disability compared to the control.
However, according to the returned questionnaires from the participants, researchers surprisingly found that patients given ginger are more than twice as likely to discontinue treatment compared to placebo.
Dr. Mozaffari-Khosravi H, the lead author, launched a joint study to determine ginger powder's effects in relieving pain and inflammation in patients with osteoarthritis.
120 participants selected for the randomized double-blind placebo-controlled 3-month clinical trial for knee osteoarthritis were randomly assigned to one of two groups: the ginger group (GG) or the placebo group (PG).
Ginger selected group was given capsules containing 500 mg of ginger powder, while the PG group was given capsules filled with 500 mg starch.
At the baseline, proinflammatory cytokine concentrations did not differ by group, as observed by the participant's blood sample.
After 3 months, GG showed a significant reduction of cytokines compared to the PG.
In the final report, the research team wrote, "Ginger supplementation may have promising benefits for knee osteoarthritis".
These results reconfirming the use of ginger for the treatment of osteoarthritis in traditional medicine with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials by Bartels EM1, Folmer VN2, Bliddal H2, Altman RD3, Juhl C4, Tarp S2, Zhang W5, Christensen R. (PubMed)
(2) Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial by Mozaffari-Khosravi H1,2, Naderi Z1, Dehghan A3, Nadjarzadeh A1, Fallah Huseini H. (PubMed)
(3) Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression by Giuseppe Musumeci,1,* Flavia Concetta Aiello,1 Marta Anna Szychlinska,1Michelino Di Rosa,2 Paola Castrogiovanni,1 and Ali Mobasheri. (PubMed)
Ginger may have a potential and positive effect in ameliorating the symptoms of pain and complications of reduced quality of life in patients with osteoarthritis, some scientists suggested.
Osteoarthritis (OA) is a chronic condition a type of joint disease characterized by the breaking down of joint cartilage and underlying bone due to the “wear and tear” of joints over time.
Some researchers suggested that OA is a degenerative disease characterized by “low-grade inflammation” in the cartilage and synovium, affecting the joint structure and progressive deterioration of cartilage.
According to the statistics from the NIH, osteoarthritis (OA) is the most common joint disorder in the US. Among adults, 60 years of age or older the prevalence of symptomatic knee and sadly OA affects approximately 10% of men and 13% of women.
Epidemiological strongly suggest that obesity and overweight which have a strong impact on weight-bearing joints, the genetic preposition of a patient can make such a patient more susceptible to the disease compared to others who do not, people with a joint injury that did heal properly at a younger age and people with occupations that require standing for long periods of time, repetitive bending, heavy lifting or other movements and the increase in age are associated to the increased risk of the onset of the disease.
The most common symptoms of osteoarthritis are joint pain and stiffness.
Dr. Giuseppe Musumeci, the lead author in the study "Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression" suggested that besides the risk factors mentioned above, dietary factors also play an important role in the onset of the disease.
In the dietary aspect in the induction of OA, the research team wrote, "This diet (The Western diet) is mainly constituted by preservative and harmful substances, such as animal fat and glucose excessive concentration and lack of nutritional factors, such as vitamins and nutrient minerals essential for our body. Moreover, bad dietary habits may predispose people to obesity, which is responsible for both metabolic destroying processes affecting the cartilage and overload of the joints, especially hips and knees".
And, " Quantity and quality of nutrient intake. Low intake of vitamin D and vitamin C is a possible risk factor for knee OA, while certain food groups, such as milk and dairy products, meat, and poultry are beneficial for knee OA. Thus we could affirm that nutritional imbalance, combined with endocrine abnormalities, may be involved in the pathogenesis of OA".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to reaffirm the traditional use of ginger for the treatment of osteoarthritis, a joint review led by the Copenhagen University Hospital, Bispebjerg, and Frederiksberg was conducted to assess the clinical efficacy and safety of oral ginger for the symptomatic treatment of osteoarthritis (OA).
The study was carried out by searching the randomized controlled trials (RCTs) comparing oral ginger treatment with placebo in OA patients aged >18 years satisfied the predetermined guidelines and criteria, including the outcomes of the reduction in pain and disability.
Out of 122 retrieved references, 117 were discarded, and only 5 five trials (593 patients) were selected for meta-analyses.
All 5 remaining studies suggested that ginger intake scored a statistically significant pain reduction.
Furthermore, the application of ginger in subjects with osteoarthritis demonstrates a statistically significant reduction in disability compared to the control.
However, according to the returned questionnaires from the participants, researchers surprisingly found that patients given ginger are more than twice as likely to discontinue treatment compared to placebo.
Dr. Mozaffari-Khosravi H, the lead author, launched a joint study to determine ginger powder's effects in relieving pain and inflammation in patients with osteoarthritis.
120 participants selected for the randomized double-blind placebo-controlled 3-month clinical trial for knee osteoarthritis were randomly assigned to one of two groups: the ginger group (GG) or the placebo group (PG).
Ginger selected group was given capsules containing 500 mg of ginger powder, while the PG group was given capsules filled with 500 mg starch.
At the baseline, proinflammatory cytokine concentrations did not differ by group, as observed by the participant's blood sample.
After 3 months, GG showed a significant reduction of cytokines compared to the PG.
In the final report, the research team wrote, "Ginger supplementation may have promising benefits for knee osteoarthritis".
These results reconfirming the use of ginger for the treatment of osteoarthritis in traditional medicine with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials by Bartels EM1, Folmer VN2, Bliddal H2, Altman RD3, Juhl C4, Tarp S2, Zhang W5, Christensen R. (PubMed)
(2) Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial by Mozaffari-Khosravi H1,2, Naderi Z1, Dehghan A3, Nadjarzadeh A1, Fallah Huseini H. (PubMed)
(3) Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression by Giuseppe Musumeci,1,* Flavia Concetta Aiello,1 Marta Anna Szychlinska,1Michelino Di Rosa,2 Paola Castrogiovanni,1 and Ali Mobasheri. (PubMed)
#BrassicaFood Plants Regulate Parameters Associated with a Reduced Risk of Cardiac Hypertrophy, Researchers Say
Kyle J. Norton
Hypertrophy is a process or condition that increases and growth of muscle cells by increasing the muscular size achieved through exercise.
Lifting weights is the most common way to increase hypertrophy.
In other words, hypertrophy is the enlargement of an organ or tissue from the increase in the size of its cells by increasing the number of contractile proteins in each muscle fiber.
There are two types of muscular hypertrophy including the growth of muscle contraction parts or myofibrillar and the increased muscle glycogen storage or sarcoplasmic.
Myofibrillar training improves strength and speed, compared to sarcoplasmic growth that sustains more energy in endurance athletic events.
Cardiac hypertrophy is a medical condition associated with the abnormal enlargement, or thickening, of the heart muscle.
The most common causes of cardiac hypertrophy are the results of hypertension or valvular disease.
The condition can also be caused by athletic hypertrophy (a condition related to exercise), valve disease, hypertrophic cardiomyopathy (HOCM), and congenital heart disease.
The most common symptoms are shortness of breath, chest pain, and palpitation, especially during exercise.
In finding a potential compound that attenuates cardiac H9c2 cell hypertrophy, researchers examined the effects of 3,3'-Diindolylmethane (DIM) is the major product of the acid-catalyzed condensation of indole-3-carbinol (I3C), a component of extracts of Brassica food plants.
The study was conducted using an in vitro model with 1 µM angiotensin II (Ang II) in cultured rat cardiac H9c2 cells, to observe the effects of DIM on cardiac hypertrophy.
According to the tested analysis, the optimal concentration of DIM for 6, 12, and 24 h. showed a significant effect on the atrial natriuretic peptide, brain natriuretic peptide, and myosin heavy chain β mRNA expression induced by Ang II in H9c2 cells.
In other words, DIM lowers the blood pressure, promotes diuresis, natriuresis, vasodilation of the systemic and pulmonary vasculature, and reduction of circulating levels of endothelin and aldosterone and cardiac muscle contraction induced by Ang II in H9c2 cells.
Furthermore, H9c2 cells treated with DIM for 0, 15, 30, and 60 min induced by Ang II also improve the function of 5'-AMP-activated protein kinase catalytic subunit alpha-1 that regulates the activities of a number of key metabolic enzymes in protecting the cardiac cells from stresses in response to hypertrophic stimuli.
Based on the findings, Brassica food plants consist of DIM that may be used for the prevention of cardiac hypertrophy, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane attenuates cardiac H9c2 cell hypertrophy through 5'-adenosine monophosphate-activated protein kinase-α by Zong J1, Wu QQ1, Zhou H1, Zhang JY1, Yuan Y1, Bian ZY1, Deng W1, Dai J1, Li FF1, Xu M1, Fang Y1, Tang QZ. (PubMed)
Hypertrophy is a process or condition that increases and growth of muscle cells by increasing the muscular size achieved through exercise.
Lifting weights is the most common way to increase hypertrophy.
In other words, hypertrophy is the enlargement of an organ or tissue from the increase in the size of its cells by increasing the number of contractile proteins in each muscle fiber.
There are two types of muscular hypertrophy including the growth of muscle contraction parts or myofibrillar and the increased muscle glycogen storage or sarcoplasmic.
Myofibrillar training improves strength and speed, compared to sarcoplasmic growth that sustains more energy in endurance athletic events.
Cardiac hypertrophy is a medical condition associated with the abnormal enlargement, or thickening, of the heart muscle.
The most common causes of cardiac hypertrophy are the results of hypertension or valvular disease.
The condition can also be caused by athletic hypertrophy (a condition related to exercise), valve disease, hypertrophic cardiomyopathy (HOCM), and congenital heart disease.
The most common symptoms are shortness of breath, chest pain, and palpitation, especially during exercise.
In finding a potential compound that attenuates cardiac H9c2 cell hypertrophy, researchers examined the effects of 3,3'-Diindolylmethane (DIM) is the major product of the acid-catalyzed condensation of indole-3-carbinol (I3C), a component of extracts of Brassica food plants.
The study was conducted using an in vitro model with 1 µM angiotensin II (Ang II) in cultured rat cardiac H9c2 cells, to observe the effects of DIM on cardiac hypertrophy.
According to the tested analysis, the optimal concentration of DIM for 6, 12, and 24 h. showed a significant effect on the atrial natriuretic peptide, brain natriuretic peptide, and myosin heavy chain β mRNA expression induced by Ang II in H9c2 cells.
In other words, DIM lowers the blood pressure, promotes diuresis, natriuresis, vasodilation of the systemic and pulmonary vasculature, and reduction of circulating levels of endothelin and aldosterone and cardiac muscle contraction induced by Ang II in H9c2 cells.
Furthermore, H9c2 cells treated with DIM for 0, 15, 30, and 60 min induced by Ang II also improve the function of 5'-AMP-activated protein kinase catalytic subunit alpha-1 that regulates the activities of a number of key metabolic enzymes in protecting the cardiac cells from stresses in response to hypertrophic stimuli.
Based on the findings, Brassica food plants consist of DIM that may be used for the prevention of cardiac hypertrophy, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane attenuates cardiac H9c2 cell hypertrophy through 5'-adenosine monophosphate-activated protein kinase-α by Zong J1, Wu QQ1, Zhou H1, Zhang JY1, Yuan Y1, Bian ZY1, Deng W1, Dai J1, Li FF1, Xu M1, Fang Y1, Tang QZ. (PubMed)
#Fennel Powder, Extract, and Oil Inhibit Nephrotoxicity through Their Antioxidant Activity, According to Studies
Kyle J. Norton
Fennel may have a potential and positive effect on excess water and toxins from the body, some scientists suggested.
The result was reported on online medical literature conducted by some respectable institutes, including John Wiley & Sons, Ltd . and UFR Physiologie-Pharmacologie over different aspects via a number of mechanisms.
Diuresis is a medicine for the stimulation of increased production of urine.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In animal models, according to John Wiley & Sons, Ltd. in the evaluation of the toxic effect of hydroalcoholic extracts of Foeniculum vulgare var dulce (D.C) root, application of the extract exerted significant activities in flushing out of excess water and toxin from the body through increased kidney function in secretion of the urine.
The result of these properties was observed by an increase in urine flow and urinary sodium excretion.
The efficacy in cleansing the body was also found linearly in dose dose-dependent manner.
Continuously, in further examination of the efficacy of fennel powder, extract, and oil on gentamicin-induced nephrotoxicity through a study of a total of 35 adult female Sprague Dawley rats classified into five groups with the first group kept on a standard diet all over the period of the experiment. and the other groups were administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either the control (+ve) group or treated groups with fennel powder, extract, and oil for 45 days, At the end of study, Researchers found that
* The injected gentamicin group served as control and exhibited strong nephrotoxicity manifested by increased levels of kidney function indicator, serum nitric oxide (NO), and kidney malondialdehyde (MDA) however, this group of rats also exerted a significant decrease in weight gain.
Increased expression of serum nitric oxide (NO) and kidney malondialdehyde (MDA) is an indicator of severed oxidative stress caused by an imbalanced ratio of ROS and antioxidants in the host.
* Gentamicin groups treated with fennel powder, extract and oil demonstrated an improved level of urea and uric acid in comparison to control (+ve) and displayed an improvement of antioxidant enzymes as the increase of serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.
These results addressed the important antioxidant effect of fennel extracts. Applications not only inhibited the levels of free radicals and their' chain reactive activities but also stimulated the production of antioxidants found in the host tissue.
* Moreover, the group treated with fennel oil restored the normal values of kidney antioxidant enzymes compared with a normal group and other treatment groups.
Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account other co and confounders said, "fennel powder, extract, and oil have a potent antioxidant and ameliorate in rats gentamicin induced nephrotoxicity in rats".
Clearly, fennel oil exhibited the greatest effect in stimulating kidney function in detoxing the body toxins through increased secretion of urine in comparison to another experimental group.
The results of this study clearly indicate that fennel powder, extract, and oil have a potent antioxidant and ameliorate in rats gentamicin-induced nephrotoxicity in rats. [Soheir Ahamed Al-Masri and Waffa, Sh. Ali. The Ameliorating
Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduced hypertension through Foeniculum increased water, sodium and potassium excretion in compared to non effect of Marrubium treated group.
Additionally, compared to Marrubium extract in reduced hypertension through inhibited contractile responses, fennel restored the normal; blood pressure by increased urine secretion and ameliorated the overexpression of ROS and increased antioxidant status in the host.
Surely, one can say that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity.
Taken together, fennel and its extracts may be considered a detox functional food in getting rid of body toxins through its diuretic activities.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's News, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin, and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N.(PubMed)
Fennel may have a potential and positive effect on excess water and toxins from the body, some scientists suggested.
The result was reported on online medical literature conducted by some respectable institutes, including John Wiley & Sons, Ltd . and UFR Physiologie-Pharmacologie over different aspects via a number of mechanisms.
Diuresis is a medicine for the stimulation of increased production of urine.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In animal models, according to John Wiley & Sons, Ltd. in the evaluation of the toxic effect of hydroalcoholic extracts of Foeniculum vulgare var dulce (D.C) root, application of the extract exerted significant activities in flushing out of excess water and toxin from the body through increased kidney function in secretion of the urine.
The result of these properties was observed by an increase in urine flow and urinary sodium excretion.
The efficacy in cleansing the body was also found linearly in dose dose-dependent manner.
Continuously, in further examination of the efficacy of fennel powder, extract, and oil on gentamicin-induced nephrotoxicity through a study of a total of 35 adult female Sprague Dawley rats classified into five groups with the first group kept on a standard diet all over the period of the experiment. and the other groups were administered gentamicin (100 mg/kg/day for 7 days i.p), followed by either the control (+ve) group or treated groups with fennel powder, extract, and oil for 45 days, At the end of study, Researchers found that
* The injected gentamicin group served as control and exhibited strong nephrotoxicity manifested by increased levels of kidney function indicator, serum nitric oxide (NO), and kidney malondialdehyde (MDA) however, this group of rats also exerted a significant decrease in weight gain.
Increased expression of serum nitric oxide (NO) and kidney malondialdehyde (MDA) is an indicator of severed oxidative stress caused by an imbalanced ratio of ROS and antioxidants in the host.
* Gentamicin groups treated with fennel powder, extract and oil demonstrated an improved level of urea and uric acid in comparison to control (+ve) and displayed an improvement of antioxidant enzymes as the increase of serum superoxide dismutase(SOD), catalase, and glutathione transferase (GST) and decrease of serum NO in compared to control (+ve) group.
These results addressed the important antioxidant effect of fennel extracts. Applications not only inhibited the levels of free radicals and their' chain reactive activities but also stimulated the production of antioxidants found in the host tissue.
* Moreover, the group treated with fennel oil restored the normal values of kidney antioxidant enzymes compared with a normal group and other treatment groups.
Dr. Soheir Ahamed Al-Masri, the lead author, after taking into account other co and confounders said, "fennel powder, extract, and oil have a potent antioxidant and ameliorate in rats gentamicin induced nephrotoxicity in rats".
Clearly, fennel oil exhibited the greatest effect in stimulating kidney function in detoxing the body toxins through increased secretion of urine in comparison to another experimental group.
The results of this study clearly indicate that fennel powder, extract, and oil have a potent antioxidant and ameliorate in rats gentamicin-induced nephrotoxicity in rats. [Soheir Ahamed Al-Masri and Waffa, Sh. Ali. The Ameliorating
Interestingly, in spontaneously hypertensive rats (SHR) treated with either water extract of Marrubium vulgare L. or Foeniculum vulgare L. in normotensive Wistar-Kyoto rats (WKY), researchers showed that application of fennel water extract reduced hypertension through Foeniculum increased water, sodium and potassium excretion in compared to non effect of Marrubium treated group.
Additionally, compared to Marrubium extract in reduced hypertension through inhibited contractile responses, fennel restored the normal; blood pressure by increased urine secretion and ameliorated the overexpression of ROS and increased antioxidant status in the host.
Surely, one can say that Foeniculum acts mainly as a diuretic and a natriuretic while Marrubium displays vascular relaxant activity.
Taken together, fennel and its extracts may be considered a detox functional food in getting rid of body toxins through its diuretic activities.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's News, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Diuretic action of hydroalcohol extracts oilFoeniculum vulgare var dulce (D.C.) roots in rats by
D. Beaux, J. Fleurentin, and F. Mortier(Wiley Online Library)
(2) The Ameliorating Effects of Fennel Powder, Extract and Oil on Gentamicin Induced Nephrotoxicity in Rats 1 Soheir Ahamed Al-Masri and 2 Waffa, Sh. Ali( Journal of American Science)
(3) Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat by El Bardai S1, Lyoussi B, Wibo M, Morel N.(PubMed)
#Healthy Food #Onion Inhibit of Angiogenesis Associated with #CancerCell Migration, Apoptosis and Invasion, According to Studies
Kyle J. Norton
Angiogenesis is the process that promotes the formation of new blood vessels involving many factors including the migration, growth, and differentiation of endothelial cells.
In normal cells, angiogenesis is important for the cells to obtain nutrients and metabolites through the small blood vessels. Angiogenesis has been found to process a therapeutic effect for the treatment of ischemic heart disease, peripheral arterial disease, and wound healing.
Dr. Papetti M, the lead scientist at the Tufts University School of Medicine said, "Normal angiogenesis ensures that developing or healing tissues receive an adequate supply of nutrients".
In cancers, angiogenesis stimulated by the tumor cells has been associated with tumor proliferation and metastasis.
More precisely, the angiogenesis process is a function of a double sword, on one hand, the process provides an ideal condition for the treatment of diseases and wound healing. On the other hand, it promotes invasive and overgrowth tumor.
Dr. Papetti M continued, "Tumor cells induce the formation of new blood supply from the preexisting vasculature, and this affords tumor cells the ability to survive and propagate in a hostile environment"
Collectively, " both normal and tumor-induced neovascularization fulfill the essential role of satisfying the metabolic demands of tissue".
Based on the findings some researchers suggested, that by inhibiting the process of blood vessel formation of the tumor, cancer may be curable.
Dr. Dai X, the lead researchers in the study of "Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis" showed, "trichosanthin TCS, ( an immunosuppressive and anti-tumor protein) inhibits murine B-cell lymphoma growth by anti-angiogenesis was reported. First, TCS inhibit tumor growth and prolonged survival significantly in vivo, and TCS depressed the formation of new blood vessels around the tumor in a dose-dependent manner".
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
In finding a potent ingredient that processes anti-cancer activity researchers studied the antiangiogenic activity of quercetin isolated from onion, using ex vivo, in vivo, and in vitro models.
According to the tested differentiation, quercetin at non-toxic concentrations significantly inhibited the microvessel sprouting associated with cancer cell proliferation.
Furthermore, the activity of cancer cell migration, invasion, and tube formation of endothelial cells involved in the process of angiogenesis.was also significantly decreased by the administration of quercetin.
Quercetin treatment inhibited ex vivo angiogenesis observed by chicken egg chorioallantoic membrane assay (CAM) and matrigel plug assay.
Moreover, quercetin suppressed vascular endothelial growth factor (VEGF) which has been found to induce the formation of a blood vessel for the progression of the tumor.
Additionally, downstream pathways associated with the promotion of survival and growth in response to extracellular signals that induce angiogenesis were also inhibited by quercetin in HUVECs.
Quercetin at the concentration of 20 mg/kg/d significantly reduced the volume and the weight of solid tumors in a prostate xenograft mouse model by targeting angiogenesis.
Quercetin was also found to inhibit the cancer cell viability and induce apoptosis in prostate cancer cells.
In other words, quercetin inhibits tumor growth and angiogenesis by targeting the proteins and signaling pathways that initiate the growth of new blood vessels.
Taken altogether, onion processed with a higher amount of quercetin may be considered a remedy for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways by Poyil Pratheeshkumar, Amit Budhraja, Young-Ok Son, Xin Wang, Zhuo Zhang, Songze Ding, Lei Wang, Andrew Hitron, Jeong-Chae Lee, Mei Xu, Gang Chen, Jia Luo, and Xianglin Shi. (Plos One)
(2) Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis by Dai X1,2, Jiang P2, Ji Y3, Zhu X2, Sun X. (PubMed)
Angiogenesis is the process that promotes the formation of new blood vessels involving many factors including the migration, growth, and differentiation of endothelial cells.
In normal cells, angiogenesis is important for the cells to obtain nutrients and metabolites through the small blood vessels. Angiogenesis has been found to process a therapeutic effect for the treatment of ischemic heart disease, peripheral arterial disease, and wound healing.
Dr. Papetti M, the lead scientist at the Tufts University School of Medicine said, "Normal angiogenesis ensures that developing or healing tissues receive an adequate supply of nutrients".
In cancers, angiogenesis stimulated by the tumor cells has been associated with tumor proliferation and metastasis.
More precisely, the angiogenesis process is a function of a double sword, on one hand, the process provides an ideal condition for the treatment of diseases and wound healing. On the other hand, it promotes invasive and overgrowth tumor.
Dr. Papetti M continued, "Tumor cells induce the formation of new blood supply from the preexisting vasculature, and this affords tumor cells the ability to survive and propagate in a hostile environment"
Collectively, " both normal and tumor-induced neovascularization fulfill the essential role of satisfying the metabolic demands of tissue".
Based on the findings some researchers suggested, that by inhibiting the process of blood vessel formation of the tumor, cancer may be curable.
Dr. Dai X, the lead researchers in the study of "Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis" showed, "trichosanthin TCS, ( an immunosuppressive and anti-tumor protein) inhibits murine B-cell lymphoma growth by anti-angiogenesis was reported. First, TCS inhibit tumor growth and prolonged survival significantly in vivo, and TCS depressed the formation of new blood vessels around the tumor in a dose-dependent manner".
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a closely related of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
In finding a potent ingredient that processes anti-cancer activity researchers studied the antiangiogenic activity of quercetin isolated from onion, using ex vivo, in vivo, and in vitro models.
According to the tested differentiation, quercetin at non-toxic concentrations significantly inhibited the microvessel sprouting associated with cancer cell proliferation.
Furthermore, the activity of cancer cell migration, invasion, and tube formation of endothelial cells involved in the process of angiogenesis.was also significantly decreased by the administration of quercetin.
Quercetin treatment inhibited ex vivo angiogenesis observed by chicken egg chorioallantoic membrane assay (CAM) and matrigel plug assay.
Moreover, quercetin suppressed vascular endothelial growth factor (VEGF) which has been found to induce the formation of a blood vessel for the progression of the tumor.
Additionally, downstream pathways associated with the promotion of survival and growth in response to extracellular signals that induce angiogenesis were also inhibited by quercetin in HUVECs.
Quercetin at the concentration of 20 mg/kg/d significantly reduced the volume and the weight of solid tumors in a prostate xenograft mouse model by targeting angiogenesis.
Quercetin was also found to inhibit the cancer cell viability and induce apoptosis in prostate cancer cells.
In other words, quercetin inhibits tumor growth and angiogenesis by targeting the proteins and signaling pathways that initiate the growth of new blood vessels.
Taken altogether, onion processed with a higher amount of quercetin may be considered a remedy for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways by Poyil Pratheeshkumar, Amit Budhraja, Young-Ok Son, Xin Wang, Zhuo Zhang, Songze Ding, Lei Wang, Andrew Hitron, Jeong-Chae Lee, Mei Xu, Gang Chen, Jia Luo, and Xianglin Shi. (Plos One)
(2) Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis by Dai X1,2, Jiang P2, Ji Y3, Zhu X2, Sun X. (PubMed)
#Phytochemical 3,3'-#Diindolylmethane Inhibits Pro-Inflammatory Cytokines Against #OxidativeStress-Induced Cardiac Injury
Kyle J. Norton
The heart muscle or myocardium is one of three types of muscles in humans, that build the walls of the heart.
The most common diseases of heart muscle include angina pectoris myocardial infarction, and other heart muscle disease caused by restricting blood supply to the muscle.
The most common symptoms of heart muscle diseases include tightness, pain, or swelling of the legs, ankles, and feet
Some patients may also experience symptoms of gastrointestinal discomforts include bloating, abdominal pain and shortness of breath caused by the reduced blood supply.
The most common risk factors associated with heart muscle disease include high blood pressure, heart tissue damage, heart problems, metabolic syndrome, nutritional deficiencies, excessive alcohol drinking.
Some researchers suggested that genetic preposition may have a strong effect on the induction of heart muscle disease.
The Genetics Home Reference wrote, " mutations in more than 30 genes have been found to cause familial dilated cardiomyopathy. These genes provide instructions for making proteins that are found in cardiac muscle cells called cardiomyocytes.
And, "Mutations in one gene, TTN, account for approximately 20 percent of cases of familial dilated cardiomyopathy".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.
In finding a natural ingredient that protects the heart muscle against the onset of cardiovascular disease researchers examined the 3, 3'-Diindolylmethane (DIM) effects on cardiomyocytes.
Tested cell lines H9C2 used in the study were evaluated by DIM's influence on inflammation and apoptosis of cardiomyocytes induced by LPS. H9C2 cells incubated with DIM (10, 20, and 30 μM) with or without LPS for 24 h.
Treatment with various concentrations of DIM (10, 20, and 30 μM) inhibited the overabundance of pro-inflammatory cytokines (TNF-α and IL-6 mRNA expression) induced by LPS.
In other words, DIM normalized the levels of impaired TNF-α and IL-6 mRNA expression, in the LPS + DIM30(μM) group.
According to the tested assays, DIM treatment significantly blocked LPS-induced oxidative stress and inhibited LPS-induced apoptosis in H9C2 cardiomyocytes.
Furthermore, DIM significantly inhibited the LPS-induced expression of a protein associated with proapoptosis and enhanced the expression of a protein involved in anti-apoptosis.
Dr. Luo Q, the lead scientist, wrote in the final report, "DIM may have a protective effect for H9C2 cardiomyocytes against LPS-induced inflammatory response and apoptosis. DIM may be a new insight into the treatment of septic cardiomyopathy".
In order to find out more information about DIM anti-cardiovascular disease activity, researchers evaluated the function of DIM on hypoxia‑induced cardiac injury.
The study included H9c2 cells pretreated with DIM (1, 5 and 10 µM) for 12 h and exposed to hypoxia for 12 h.
DIM with different doses extended markedly attenuated the increased transcription of pro-inflammatory cytokines (interleukin (IL)‑1β, IL‑6, and tumor necrosis factor‑α) induced by hypoxia.
DIM also modulated the genes associated with transcription of autophagy, compared with the hypoxia group.
DIM also protected the cells against apoptosis by inhibiting and exhibiting the proteins associated with anti-apoptosis and pro-apoptosis, respectively.
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the protection of heart muscle against the risk of heart disease, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane protects cardiomyocytes from LPS-induced inflammatory response and apoptosis by Luo Q1,2,3, Yang A1,2,3, Cao Q1,2,3, Guan H. (PubMed)
(2) 3,3'‑Diindolylmethane attenuates cardiomyocyte hypoxia by modulating autophagy in H9c2 cells by Liang K1, Qian WH1, Zong J. (PubMed)
(3) Familial dilated cardiomyopathy by The Genetics Home Reference. (NIH)
The heart muscle or myocardium is one of three types of muscles in humans, that build the walls of the heart.
The most common diseases of heart muscle include angina pectoris myocardial infarction, and other heart muscle disease caused by restricting blood supply to the muscle.
The most common symptoms of heart muscle diseases include tightness, pain, or swelling of the legs, ankles, and feet
Some patients may also experience symptoms of gastrointestinal discomforts include bloating, abdominal pain and shortness of breath caused by the reduced blood supply.
The most common risk factors associated with heart muscle disease include high blood pressure, heart tissue damage, heart problems, metabolic syndrome, nutritional deficiencies, excessive alcohol drinking.
Some researchers suggested that genetic preposition may have a strong effect on the induction of heart muscle disease.
The Genetics Home Reference wrote, " mutations in more than 30 genes have been found to cause familial dilated cardiomyopathy. These genes provide instructions for making proteins that are found in cardiac muscle cells called cardiomyocytes.
And, "Mutations in one gene, TTN, account for approximately 20 percent of cases of familial dilated cardiomyopathy".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.
In finding a natural ingredient that protects the heart muscle against the onset of cardiovascular disease researchers examined the 3, 3'-Diindolylmethane (DIM) effects on cardiomyocytes.
Tested cell lines H9C2 used in the study were evaluated by DIM's influence on inflammation and apoptosis of cardiomyocytes induced by LPS. H9C2 cells incubated with DIM (10, 20, and 30 μM) with or without LPS for 24 h.
Treatment with various concentrations of DIM (10, 20, and 30 μM) inhibited the overabundance of pro-inflammatory cytokines (TNF-α and IL-6 mRNA expression) induced by LPS.
In other words, DIM normalized the levels of impaired TNF-α and IL-6 mRNA expression, in the LPS + DIM30(μM) group.
According to the tested assays, DIM treatment significantly blocked LPS-induced oxidative stress and inhibited LPS-induced apoptosis in H9C2 cardiomyocytes.
Furthermore, DIM significantly inhibited the LPS-induced expression of a protein associated with proapoptosis and enhanced the expression of a protein involved in anti-apoptosis.
Dr. Luo Q, the lead scientist, wrote in the final report, "DIM may have a protective effect for H9C2 cardiomyocytes against LPS-induced inflammatory response and apoptosis. DIM may be a new insight into the treatment of septic cardiomyopathy".
In order to find out more information about DIM anti-cardiovascular disease activity, researchers evaluated the function of DIM on hypoxia‑induced cardiac injury.
The study included H9c2 cells pretreated with DIM (1, 5 and 10 µM) for 12 h and exposed to hypoxia for 12 h.
DIM with different doses extended markedly attenuated the increased transcription of pro-inflammatory cytokines (interleukin (IL)‑1β, IL‑6, and tumor necrosis factor‑α) induced by hypoxia.
DIM also modulated the genes associated with transcription of autophagy, compared with the hypoxia group.
DIM also protected the cells against apoptosis by inhibiting and exhibiting the proteins associated with anti-apoptosis and pro-apoptosis, respectively.
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the protection of heart muscle against the risk of heart disease, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane protects cardiomyocytes from LPS-induced inflammatory response and apoptosis by Luo Q1,2,3, Yang A1,2,3, Cao Q1,2,3, Guan H. (PubMed)
(2) 3,3'‑Diindolylmethane attenuates cardiomyocyte hypoxia by modulating autophagy in H9c2 cells by Liang K1, Qian WH1, Zong J. (PubMed)
(3) Familial dilated cardiomyopathy by The Genetics Home Reference. (NIH)
#Herbal #Turmeric Inhibits Kidney Damage and Injury Associated with Drugs, Heavy Metals and Substances Toxicity, Researchers Say
Kyle J. Norton
The kidneys are a pair of kidney-shaped organs located on either side of your spine with a function to filter out the wastes from the blood before passing the wastes through urinary secretion.
More than a detoxed organ, the kidneys also maintain the body fluid balance and regulate the production of red blood cells and high blood pressure.
Kidney damage can be acute such as an overdose of toxin or chronic. Acute kidney diseases can be cured if the underlying cause is found.
Chronic kidney disease (CKD) is a slow and progressive disease that can lead to kidney failure over time.
The advance of CKD can cause dangerous levels of fluid, electrolytes, and waste build-up in the body.
According to statistics, approximately 14 percent of the US general population suffers from CKD. Believe it or not, more than 661,000 Americans have kidney failure. Of these, 468,000 individuals are on dialysis, and roughly 193,000 live with a functioning kidney transplant.
Out of many risk factors associated with CKD, some researchers suggest high blood pressure is one most prevalent risk factors found in most patients.
The Natural Kidney Foundation wrote, "More than half the people with chronic kidney disease (CKD) have high blood pressure. High blood pressure increases the chance that kidney disease will get worse"
And "Following your treatment plan carefully and keeping your blood pressure under control can help to prevent these complications".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In finding a potential compound with kidney protective properties, researchers investigated curcumin, a major phenolic compound the rhizome of the Curcuma species kidney toxicity.
In glucose, tartrazine-induced toxicity, curcumin protected the kidney against DNA damage in leucocytes.
In a streptozotocin-induced diabetes rat model, curcumin protected the kidney against overexpression of free radicals to cause kidney cell damage through its antioxidant activity.
In the long-term heavy metal model, curcumin inhibited the toxic effect caused by the accumulation of the metal in the induction of kidney cell damage.
In an animal model induced cisplatin-induced acute kidney injury by injection of cisplatin, curcumin enhanced the function of cisplatin-resistant cancer cells and decreased its unwanted side effects.
More interestingly, curcumin inhibited the nicotine receptors on kidney cells that link nicotine to accelerated kidney damage in cigarette smokers
In other words. if the kidneys are less able to excrete nicotine, in the long term, accumulated extracellular fluid and blood volumes increase, which can lead to severe kidney damage.
In other studies, kidney damage caused by maleate, malathion, nicotine, cisplatin, gentamicin, and methotrexate was also reversed by the injection of curcumin, similar to those of the aforementioned substances.
Taken altogether, turmeric and its bioactive compound curcumin may be considered remedies for the prevention and treatment of kidney damage, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(2) Protective effects of curcumin against toxic agents-induced renal failure: a review by Farkhondeh T1, Samarghandian S2, Azimi-Nezhad M2, Shahri AMP. (PubMed)
(3) High Blood Pressure and Chronic Kidney Disease by The Natural Kidney Foundation
The kidneys are a pair of kidney-shaped organs located on either side of your spine with a function to filter out the wastes from the blood before passing the wastes through urinary secretion.
More than a detoxed organ, the kidneys also maintain the body fluid balance and regulate the production of red blood cells and high blood pressure.
Kidney damage can be acute such as an overdose of toxin or chronic. Acute kidney diseases can be cured if the underlying cause is found.
Chronic kidney disease (CKD) is a slow and progressive disease that can lead to kidney failure over time.
The advance of CKD can cause dangerous levels of fluid, electrolytes, and waste build-up in the body.
According to statistics, approximately 14 percent of the US general population suffers from CKD. Believe it or not, more than 661,000 Americans have kidney failure. Of these, 468,000 individuals are on dialysis, and roughly 193,000 live with a functioning kidney transplant.
Out of many risk factors associated with CKD, some researchers suggest high blood pressure is one most prevalent risk factors found in most patients.
The Natural Kidney Foundation wrote, "More than half the people with chronic kidney disease (CKD) have high blood pressure. High blood pressure increases the chance that kidney disease will get worse"
And "Following your treatment plan carefully and keeping your blood pressure under control can help to prevent these complications".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In finding a potential compound with kidney protective properties, researchers investigated curcumin, a major phenolic compound the rhizome of the Curcuma species kidney toxicity.
In glucose, tartrazine-induced toxicity, curcumin protected the kidney against DNA damage in leucocytes.
In a streptozotocin-induced diabetes rat model, curcumin protected the kidney against overexpression of free radicals to cause kidney cell damage through its antioxidant activity.
In the long-term heavy metal model, curcumin inhibited the toxic effect caused by the accumulation of the metal in the induction of kidney cell damage.
In an animal model induced cisplatin-induced acute kidney injury by injection of cisplatin, curcumin enhanced the function of cisplatin-resistant cancer cells and decreased its unwanted side effects.
More interestingly, curcumin inhibited the nicotine receptors on kidney cells that link nicotine to accelerated kidney damage in cigarette smokers
In other words. if the kidneys are less able to excrete nicotine, in the long term, accumulated extracellular fluid and blood volumes increase, which can lead to severe kidney damage.
In other studies, kidney damage caused by maleate, malathion, nicotine, cisplatin, gentamicin, and methotrexate was also reversed by the injection of curcumin, similar to those of the aforementioned substances.
Taken altogether, turmeric and its bioactive compound curcumin may be considered remedies for the prevention and treatment of kidney damage, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(2) Protective effects of curcumin against toxic agents-induced renal failure: a review by Farkhondeh T1, Samarghandian S2, Azimi-Nezhad M2, Shahri AMP. (PubMed)
(3) High Blood Pressure and Chronic Kidney Disease by The Natural Kidney Foundation
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