#Diphenylhydantoin and #Valproicacid Isolated From Chaste Tree Berry Process Anticonvulsant Activity, Researchers Show

Kyle J. Norton

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.

In a study using an animal model of maximal electroshock seizures (MES) and induced seizures (MES) by administrated pentylenetetrazole (PTZ), intake of ethanolic leaf extract of Vitex-negundo, at doses of 250, 500, and 1000 mg/kg p.o, exerted a significant of postictal depression, an altered state of consciousness after an epileptic seizure in the dose of 1000 mg/kg body weight in comparison to control but no effects in other applications.

At doses of (1000 mg/kg, PO), the ethanolic leaf extract exhibited a 50% half-life protection in chronic seizures after a 24-hour injection against PTZ-induced seizures. Researchers also found that the efficacy of the extract at that dose is the result of valproic acid, a major ingredient found in Chaste tree berries.

Dr. Tandon VR and co-author Dr. Gupta RK. of the study said, " The anticonvulsant activity of Vitex-negundo has not been found quite effective with standard drugs".


Furthermore, because the potentiation of diphenylhydantoin and valproic acid isolated Vitex-negundo displayed a significant effect in treating animal models, the extract may be used as an adjuvant therapy along with standard anticonvulsants.

Additionally, according to the Baqiyatallah University of Medical Sciences, hydrophilic extract of Vitex agnus castus fruit (Vitex) administered doses (60, 120, or 180 mg/kg) showed a strong anticonvulsant activity even at low doses (60 mg/kg) of Vitex by increasing the afterdischarge(AD) threshold and decrease the afterdischarge duration ( ADD) and stage 5 duration (S5D).


Promisingly, at the highest dose, the extract inhibited significantly the seizure stage (P<0.01) and reduced or prevented epileptic activity as demonstrated by the reduction of ADD and S5D (length of convulsion) in a dose-dependent manner.

More importantly, methanolic extract (ME) of the leaves of V. negundo also showed to process the analgesic properties and potentiated analgesia demonstrated by morphine and pethidine in protection against strychnine and leptazole-induced convulsions.

Taking together, Chaste Tree Berry may be one of the next-generation therapeutic herbal medicines that have a strong effect on the prevention and treatment of seizures as a result of abundant phytochemicals, but intake of the large amount should be taken with care to reduce the risk of toxicity.


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Sources
(1) An experimental evaluation of anticonvulsant activity of Vitex-negundo by Tandon VR1, Gupta RK.(PubMed)
(2) The antiepileptic activity of Vitex agnus castus extract on amygdala kindled seizures in male rats by Saberi M1, Rezvanizadeh A, Bakhtiarian A.(PubMed)
(2) CNS activity of Vitex negundo Linn. in mice by Gupta M1, Mazumder UK, Bhawal SR.(PubMed)

#Herbal #Angelica Improves #Hyperglycemia, Glucose Tolerance and Plasma Insulin Levels in #Diabetes in Vivos, Researchers Say

Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

The most common symptoms of diabetes are excessive thirst and hunger, frequent urination, unintended weight loss or gain, frequent fatigue, irritability, and gastrointestinal symptoms such as nausea.

Some patients may also experience symptoms of blurred vision and slow wound healing or ulcer.

Prediabetes is caused by unhealthy diets with high saturated fat, smoking, and excessive alcohol drinking. Therefore, understanding prediabetes is a very important issue for prediabetics, because with proper diets, quit smoking, control alcohol intake, and exercises, prediabetes can be reversed or delayed.

People with a glucose level between 111mg/dl-125 mg/dl are considered pre-diabetics

Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occur in patients who do not manage their diabetes properly.

Hyperglycemia, a hallmark of diabetes has been found to induce diabetics complications, including neuropathy, nephropathy, and retinopathy).

According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million who are undiagnosed and unaware of their condition.

About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.

The immune system is the set of cells and their activity against antigens or infectious agents that comprise the body's defense system against diseases.

Immunomodulatory activity is an action that improves the underactive immune function that is susceptible to the invasion of foreign microorganisms and inhibits the overactive immune system that causes autoimmune diseases.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

In finding an herbal medicine for the prevention and treatment of diabetes, researchers investigated the effects of the decoction HemoHIM on hyperglycemia and the immune response in diabetic mice.

Mice selected for the study were divided into nondiabetic and diabetic mice induced by a single injection of streptozotocin (STZ, 200 mg/kg, i.p.) orally administered HemoHIM (100 mg/kg) once a day for 4 weeks.
Diabetic mice with HemoHIM showed improved hyperglycemia and glucose tolerance as well as elevated plasma insulin levels with the preservation of insulin staining in pancreatic β-cells, compared to the diabetic control group.

Furthermore, HemoHIM treatment restored parameters associated with the onset of diabetes including thymus weight, white blood cells, lymphocyte numbers, and splenic lymphocyte populations (CD4(+) T and CD8(+) T), which were reduced in diabetic mice.

Moreover, HemoHIM also animalized the IFN-γ production associated with innate and adaptive immunity in response to Con A stimulation in facilitating mediated T cell proliferation.

Based on the results, researchers said, "HemoHIM may have potential as a glucose-lowering and immunomodulatory agent by enhancing the immune function of pancreatic β-cells in STZ-induced diabetic mice".

Taken altogether, Herbal Angelica is used in combination with other herbal medicines for the treatment of diabetes, pending to larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Immunomodulatory and Antidiabetic Effects of a New Herbal Preparation (HemoHIM) on Streptozotocin-Induced Diabetic Mice by Kim JJ1, Choi J1, Lee MK2, Kang KY3, Paik MJ3, Jo SK4, Jung U4, Park HR4, Yee ST. (PubMed)

#GreenBeans Process A Strong Anti-Platelet Aggregation Activity, According to Studies

Kyle J. Norton


Platelet aggregation refers to the platelet-to-platelet adhesion in the blood that forms a clot.
Platelet aggregation plays a critical role in the protection of the body against blood loss due to injury or tissue damage.

However, activated platelets that stimulate blood clot formation have also been found to induce atherothrombotic disease.

Antiplatelet aggregation medicines, also known as platelet agglutination inhibitors are the types of medicine that process blood thinning properties.

In other words, antiplatelet aggregation medicines reduce the risk of blood clotting used in patients who have a high risk of cardiovascular disease such as aspirin.

Coagulation disorders or bleeding disorders are medical conditions that affect blood clotting activities. The most common diseases associated with coagulation disorders are Hemophilia, Von Willebrand disease, clotting factor deficiencies, hypercoagulable states, and deep venous thrombosis.
The most common causes of the bleeding disorder are found in patients with a lower red blood cell count
and vitamin K deficiency.

However, long-term use of certain medications has also been found to have side effects of bleeding disorders.

The most common symptoms of blessing disorder are unexplained and easy bruising, heavy menstrual bleeding in women, frequent nose bleeding, excessive bleeding from small cuts or an injury
and bleeding into joints.

Dr. Copplestone JA in investigating the bleeding and coagulation disorders in the elderly wrote, "Ageing does not bring with it any major changes in the coagulation or fibrinolytic proteins or platelets. It does bring a greater burden of disease, with fewer reserves, and so when hemorrhage occurs in the elderly it has more serious consequences".


And, " Drugs are a significant and potentially preventable cause of bleeding in the elderly. The most frequent problems arise with anticoagulants. The risk of interactions increases with the number of other medications that are prescribed".

Green bean is a genus of Phaseolus Sensu Stricto, containing 55 different species, belongs to the family Fabaceae, and is native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.

In finding the natural compound that processes anti-thrombosis, researchers examined the antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables.

The study compared the effect of extracts prepared from each sample including an aqueous (juice or pressed solubles) and/or methanol-soluble fraction. at a final concentration of 1 mg/ml from samples of 19 fruits and 26 vegetables, including green beans representative of the local diet.

Extracts of green beans showed an inhibited platelet aggregation induced by ADP and arachidonic acid, in a concentration-dependent manner, compared to other extracts.

Compared to methanolic extracts of grapes prolonged activated partial thromboplastin time (APTT) and diluted prothrombin time (dPT) and raspberry prolonged APTT are higher compared to those of green beans.

Taken together, green beans may be used as an adjunct therapy for the prevention and treatment of platelet aggregation, pending the confirmation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables by Torres-Urrutia C1, Guzmán L, Schmeda-Hirschmann G, Moore-Carrasco R, Alarcón M, Astudillo L, Gutierrez M, Carrasco G, Yuri JA, Aranda E, Palomo I. (PubMed)
(2) Bleeding and coagulation disorders in the elderly by Copplestone JA. (PubMed)

#BrassicaVegetables Process #Probiotic Activity for the Promotion of Digestive Functioning, Researchers Suggest

Kyle J. Norton


The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing it to other parts of the body.
The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by reducing partly or completely the function of the liver, including liver failure.

Liver cancer is a medical condition characterized by cell growth irregularly in the liver tissue.

The causes of liver cancer are associated with the alternation of cells' DNA which normally begins in the cells on the surface of the inner lining.

Liver cancer at the early stage no not cause any symptoms. However, at the advanced stage, liver cancer cells can cause a wide range of symptoms including jaundice, abdominal swelling and pain, and dark urine and white stool accompanied by the general symptoms of cancers such as unintended weight loss, loss of appetite, chronic fatigue and tiredness and gastrointestinal discomforts.

The most common cause of liver cancer is infected by the hepatitis virus. However, in North America, due to the overexpression of the overweight and obese population, liver cancer may slowly progress from nonalcoholic fatty liver disease through cirrhosis to liver cancer.


In 2017, 2,500 Canadians were diagnosed with liver cancer and 1,200 Canadians died from liver cancer.

Compared to the early stage of other cancer, the 5 years survival rate in the early stage diagnosis is only 31%, and 43% of people with liver cancer diagnosed at stages 0 and 1.

Cabbage is a species of Brassica oleracea belonging to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem of which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find a natural food that inhibits cancer, researchers examined the bioactivity of synthetic and plant-derived 1-cyano-2,3-epithiopropane (CETP) - the predominant epithionitrile in Brassica vegetables in three human hepatocellular carcinomas (HCC) cell lines.

According to the formazan dye assays, the concentrations of 380-1500 nM CETP isolated from Brassica vegetables inhibited the mitochondrial dehydrogenase activity-induced cytotoxicity of human HCC cells without impairment of cell growth.

Furthermore, at 100-fold higher CETP concentrations, the bioactive induced cell death.

The presence of a plant matrix associated with oxidative stress increased CETP-based toxicity without exhibiting the epithionitriles in human health.


Taken together, Brassica vegetables may be considered probiotics for the promotion of digestive functioning, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Brassica epithionitrile 1-cyano-2,3-epithiopropane triggers cell death in human liver cancer cells in vitro by Hanschen FS1, Herz C2, Schlotz N2, Kupke F2,3, Bartolomé Rodríguez MM4, Schreiner M1, Rohn S3, Lamy E. (PubMed)

#GreenPlant Membrane Processes An Inhibition of the Risk of #Hypertriglyceridemia, Researchers Say

Kyle J. Norton

Triglycerides are accumulated in the blood for future use by converting any unused calories.
In other words, triglycerides are an ester derived from glycerol and three fatty acids (from tri- and glyceride).

Overexpression of hyperglyceridemia is found in patients with atherosclerosis even without the presence of high cholesterol levels, and predispose.

Hypertriglyceridemia is a condition characterized by high levels of triglycerides in the blood.

Hypertriglyceridemia can also accumulate in the arterial wall or combine with other substances to form plaque that narrows the arteries in transporting rich oxygenated blood to the heart and other parts of the body, leading to the onset of atherosclerosis.

Primary hypertriglyceridemia is found in 5% of patients associated with genetic preposition compared to 95% of secondary hypertriglyceridemia found in obese metabolic syndrome, diabetes,... patients.

Treating hypertriglyceridemia is difficult, as the condition frequently coexistence with other conditions that affect cardiovascular disease risks, such as high levels of low-density lipoprotein, obesity, metabolic syndrome, and type 2 diabetes.

In severe cases of hypertriglyceridemia, patients may also experience the complication of acute pancreatitis, independent of the risk of CVD.

On finding a potential whole food for the treatment of diabetes, researchers examined the effects of the once-daily intake of the green-plant membrane with dietary oil on postprandial hypertriglyceridemia in vitro and in vivo.

In vitro, green-plant membrane-bound hydrophobic bile acids but did not inhibit pancreatic lipase activity.

The green-plant membrane in rats, oral fat tolerance tests, and increased serum triglyceride levels were significantly reduced.


Moreover, fecal total lipid and bile acid volumes were significantly increased in rats that were administered 200 mg/mL green-plant membrane.

Based on the evidence, researchers said, "...green-plant membrane with dietary oil inhibits dietary fat absorption via promotion of bile acid excretion in feces and the effectiveness of eating green-plant membrane, such as green leafy vegetables, with meals".

Taken altogether, the green-plant membrane may be considered a functional food for the prevention of hypertriglyceridemia, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Intake of green-plant membrane with dietary oil suppresses postprandial hypertriglyceridemia in rats via promoting excretion of bile acids by Matsuda H1, Ooi S1, Otokozawa R1, Kumazaki K1, Udagawa E1, Asakura M1, Suzuki D1, Shirai T. (PubMed)

#Photocomposition (PC-1) Extract Processes a Strong Anti-Lipid Peroxidation (LPO)O and Antihemolytic Effect, Researchers Suggest

Kyle J. Norton

The liver is the largest internal and only organ in the human body that can regenerate itself.
The liver is the first line of detoxing defense by filtering the blood that comes from the digestive tract, before passing them to other organs and tissues in the body.

The liver also produces cholesterol that plays a critical role in building strong cell membranes, producing steroid hormones and vitamin D, and aiding the digestive function in food absorption and detoxifying chemicals and metabolizing drugs.

The hepatoprotective or liver protective effect is an action that maintains the healthy function of the liver against any harmful toxins.


Symptoms of liver diseases include jaundice, abdominal pain, swelling, swelling in the legs and ankles, itchy skin, dark urine, pale stool color, and a tendency to bruise easily.

There are no exact causes of liver disease. Viruses, toxins, genetics, alcohol, and unknown causes are some prevalent factors found in patients with chronic liver disease, including cancer.

In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.

Furthermore, in recent years, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used for thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches obstruction in the nasal passage, etc.

In finding a potential compound which processes a liver protective effect, researchers examined the highly active photocomposition (PC-1) containing oregano (Origanum vulgare), wild thyme (Thymus serpyllum) and coltsfoot (Tussilago farfara) aerial parts, valerian (Valeriana officinalis) leaves and little-leaf linden (Tilia cordata) flowers and PC-1 extract exhibited the strongest anti-lipid peroxidation (LPO)O and antihemolytic effects.

According to the tested results, PC-1 extract activated the Nrf2/antioxidant response is more effective compared to the extracts of other photocomposition.

Furthermore, oral administration of PC-1 extract (100-200 mg/kg) markedly protected the rat liver injury acutely or chronically against intoxication by carbon tetrachloride.

The liver protective activity of PC-1 was attributed to the activation of the levels of antioxidant enzymes in the host and the improvement of liver histology, blood chemistry parameters.

Moreover, the osmotic fragility test (OFT) also addressed that PC-1 extract inhibited the destruction of red blood cells in carbon tetrachloride intoxicated rats.

Based on the findings, researchers said, "These data support the strategy of in-vitro plant selection for developing efficacious tissue-protective photocomposition".

Taken together, coltsfoot may be considered a liver protective remedy, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A composition of medicinal plants with an enhanced ability to suppress microsomal lipid peroxidation and a protective activity against carbon tetrachloride-induced hepatotoxicity by Aralbaeva AN1, Mamataeva AT1, Zhaparkulova NI2, Utegalieva RS1, Khanin M3, Danilenko M4, Murzakhmetova MK. (PubMed)

#Phytochemical I3C and 3,3'-#Diindolylmethane Process Anti-Proliferative and #Anticancer Activities, Scientists Say

Kyle J. Norton

3,3'-Diindolylmethane or DIM may have a p[otential effect on the treatment of cancer with no side effects, according to studies.

Cancer is a group of diseases characterized by the cell growth uncontrollably in the tissue of certain organs, due to the alternation of cell DNA.

Epidemiologically, researchers do not the exact causes of cancer. They cannot explain why people with the same health conditions in the same family, are prone to the disease while others do not.

Most cases of cancer start in the cells on the surface of the inner lining tissue of an organ and at the advanced stage, cancer cells can travel a distance away from the original site to infect other tissues and organs through the circulation of blood and fluids, leading to secondary metastasis.

Cancer diagnosed at the early stage can have a survival rate of up to 100%, depending on the type of cancer.

All cancers share the general symptoms of unintended weight loss, loss of appetite, fatigue, tiredness, and gastrointestinal discomfort.

Furthermore, most cancers at the early stage do not induce any symptoms, however, at the later stage, the overgrowth tumor may press on the nearby blood vessels and nerve cells, leading to severe bleeding and pain.

Although there are several risk factors associated with the onset of cancer, some researchers suggest the increase in aging that leads to a number of abnormal alternations may be one of the major causes.

Dr. Jan R. Aunan, the lead scientist wrote in the study of the biological role of age and cancer, "Aging is the inevitable time-dependent decline in physiological organ function and is a major risk factor for cancer development".

And, "Mechanisms of aging are also found to occur in carcinogenesis, albeit with shared or divergent end-results. It is now clear that aging and cancer development either share or diverge in several disease mechanisms. Such mechanisms include the role of genomic instability, telomere attrition, epigenetic changes, loss of proteostasis, decreased nutrient sensing and altered metabolism, but also cellular senescence and stem cell function".

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.

Scientists concerned about the side effects of chemotherapy for the treatment of cancer examined the effects of I3C and its dimeric product, 3, 3'-diindolylmethane (DIM) anti-proliferative and anticancer activities against human cancer cells.

Application of I3C and its dimeric product, 3, 3'-diindolylmethane (DIM) exerted a strong activity in the inhibition of altered expression and exhibition of the functions of proteins associated with cell cycle arrest.

I3C and its dimeric product, 3, 3'-diindolylmethane (DIM) deactivated the signal transduction pathways in the stimulation of cancer cell growth.

Furthermore, the phytochemicals suppressed the genes associated with cancer cell survival and proliferation and the protein involved in the generation of new blood vessels for the tumor.

Furthermore, the tested bioactive compound also activated the protein associated with the pro-apoptosis against the gene involved in anti-apoptosis of the cancer cells.


Additionally, I3C and its dimeric product, 3, 3'-diindolylmethane (DIM) also overexpressed the gene involved in cell cycle arrest against the progression of cancer.

Dr.Noroozi MK and colleagues wrote at the end of the experiment, "I3C and its dimeric product, 3, 3'-diindolylmethane (DIM), have been widely investigated for their importance against a number of human cancers both in vitro and in vivo".

In the microRNA-21 analysis, researchers found that DIM inhibits the microRNA (miRNAs) expression against colon cancer (CAC) pathogenesis.

MicroRNAs (miRNAs) are a class of small noncoding RNAs of ∼22nt in length involved in the regulation of gene expression including inflammation and angiogenesis.

In mesothelioma, injection of DIM exerted anti-mesothelioma potentials, by lowering the expression of microRNA regulatory activities by suppressing macrophage infiltration and pro-inflammatory cytokines.

In other words, DIM modulated the immune response against the onset and progression of mesothelioma in stimulating the production of oxidative stress due to the overexpression of inflammatory cytokines in the initiation of the disease.

Taken altogether, DIM may be considered a supplement for the prevention and combined with primary medicine for the treatment of cancer, pending the confirmation of a large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Molecular targets, anti-cancer properties, and potency of synthetic indole-3-carbinol derivatives by Noroozi MK1, Mahmoodi M1, Jafarzadeh A1, Darekordi A2, Hajizadeh MR1, Hassanshahi G. (PubMed)
(2) Enhancing miR-132 expression by aryl hydrocarbon receptor attenuates tumorigenesis associated with chronic colitis by Alzahrani AM1, Hanieh H2, Ibrahim HM2, Mohafez O3, Shehata T4, Bani Ismail M2, Alfwuaires M. (PubMed)
(3) The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks by Jan R. Aunan,1,2,* William C Cho,3 and Kjetil Søreide. (PubMed)