#Phytochemical #Alliin Inhibits Metabolic Syndrome Against the Risk of #Cardiovasculardisease

Kyle J. Norton

Metabolic syndrome is a cluster of conditions that increase the risk of cardiovascular disease and diabetes, including too much fat around the waist, high blood pressure, triglycerides, and blood sugar, and low HDL cholesterol.

In other words, if you process 3 of the aforementioned conditions, you are at a higher risk of heart disease, stroke, and diabetes. However, most people with metabolic syndrome have never developed
CVD and diabetes.

Other than high blood glucose, induced thirst and urination, fatigue, and blurred vision, most patients with other metabolic conditions are asymptomatic.

Epidemiologically, aging, ethnicity, obesity, medical conditions such as diabetes, nonalcoholic fatty liver disease, and polycystic ovary syndrome are the most common risk factors found in patients with the syndrome.

Some researchers suggested that the promotion of the Western diet in the US over the past few decades may have a strong effect in inducing the widespread metabolic syndrome.

Dr. Drake I, the lead scientist wrote, "The 'Western' dietary pattern was inversely associated with HDL-cholesterol and positively with all other response variables (both at baseline and follow-up), but there was no association with LDL at follow-up".

And, " In conclusion, this study supports current food-based dietary guidelines suggesting that a 'Western' dietary pattern with high intakes of sugar-sweetened beverages and red and processed meats and low intakes of wine, cheese, vegetables, and high-fiber foods is associated with detrimental effects on cardio-metabolic health".

The results clearly suggested that if you are following a traditional diet with high fruits and vegetables and fewer processed foods, saturated and trans fat, and red meat accompanied with moderate exercise daily, you are at substantially decreased risk of metabolic syndrome, compared to those who follow the Western diet.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

In the urgency to find a potential compound for the treatment of metabolic syndrome, researchers examined pure allicin, prepared biosynthetically by reacting synthetic alliin with an immobilized alliinase enzyme the protect against cardiovascular disease.

S-ally-mercapto captopril (CPSSA), a new stable synthetic compound produced by a chemical reaction between allicin and the angiotensin-converting enzyme inhibitor captopril was tested in a fructose-induced metabolic syndrome rat model.

Allicin (8 mg/(kg day)) used alone significantly reduced insulin, triglycerides, and homocysteine concentrations, and had a slight effect on SBP associated with the risk of metabolic syndrome.

On the other hand, Captopril (50mg/(kg per day)) only improved blood pressure and homocysteine.

Treatment with a low dose of CPSSA (5mg/(kg day)) lowered SBP but did not improve any other measured parameter, while treatment with a higher dose of Captopril (50mg/(kg day)) significantly decreased blood pressure, triglycerides, and homocysteine concentrations.


In other words, CPSSA exerted a strong anti-metabolic syndrome better than those of individual compounds in a dose-dependent manner.


Based on the findings, researchers wrote, " the combined molecule CPSSA integrates the anti-hypertensive, lipid-lowering, and homocysteine-reducing effects of both allicin and captopril, making it a potential cardiovascular protective agent".

Taken together, alliin may be considered a supplement for the prevention and treatment of metabolic syndrome, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The effects of S-ally-mercapto captopril, the synthetic product of allicin and captopril, on cardiovascular risk factors associated with the metabolic syndrome by Oron-Herman M1, Rosenthal T, Mirelman D, Miron T, Rabinkov A, Wilchek M, Sela BA. (PubMed)
(2) Role of phytochemicals in the management of metabolic syndrome by Cicero AF1, Colletti A. (PubMed)
(3) A Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic syndrome by Drake I1, Sonestedt E1, Ericson U1, Wallström P2, Orho-Melander M. (PubMed)

#Phytochemical #Lycopene Is Inversely Associated with the Risk of HIV Injecting Drug Users (IDUs), Researchers Say

Kyle J. Norton

Infection is a condition that causes the invasion of stimuli and micropathogens, including viral infection.
A viral infection is a disease caused by the successful entering and multiplying of a virus in the body.

Anti-viral effects are an act in which certain substances are used to cause the destruction of a virus.

In the acute phase of viral infection, depending on the types of viruses, the viruses after entering the body start to attack the specific host cells.

The white blood cells in the systematic immune response in the acute phase of infection stimulate the production of the proinflammatory cytokines to the site of infection with an aim to protect our body by killing off the invaders.

The cold and flu virus will attack the cells in the respiratory system and the human immunodeficiency virus (HIV), which causes AIDS, attacks the white blood cells of the immune system,

The viral infection has been known to carry over some different stages, after successfully attaching to the host cell, the virus releases its mRNA into the host cell, leading to the recruitment of the host cell's enzymes to accelerate the viral multiplying, then breaking free from the host cell to start the cycle all over again.

The battle between the immune white blood cell and viral invaders in most cases an in the flavor of the side of the immune system, the invaders are killed and the infection is healed.

However, if the immune system can not kill off the invaders within 3 - 8 weeks, it then will adapt to the change, leading to chronic inflammatory and infectious diseases.

HIV infection left untreated will weaken the host immune system, leading to AIDs, a major cause of life-threatening infections and disease.

According to the statistics from the US government, approximately 1.1 million people in the U.S. are living with HIV today. About 15 percent of them (1 in 7) are unaware they are infected. In approximately38,700 Americans were newly infected with HIV.

Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas.

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In finding a potential compound for the treatment of cardiovascular diseases (HIV), researchers examined the serum antioxidant levels in 175 HIV-positive and 210 HIV-negative injecting drug users (IDUs) in Baltimore, Maryland.

According to the results of data collection of 30 HIV-positive IDUs who were receiving antiretroviral therapies (ART), mean serum levels of lycopene and lutein/zeaxanthin were significantly lower in HIV-positive IDUs than in HIV-negative IDUs.

In other words, lycopene and lutein/zeaxanthin an inversely associated with the risk of HIV injecting drug users (IDUs).

Furthermore, serum alpha-tocopherol levels were significantly higher in HIV-positive IDUs than HIV-negative IDUs (medians = 744 microg/dl and 718 microg/dl, respectively; p = 04).

Levels of antioxidant levels by ART regimen are lower among HIV-positive study subjects, comapred to the HIV-negative group.

After adjusting to other factors such as injecting drug use, dietary intake, supplement intake, gender, and alcohol intake, levels of alpha-tocopherol, beta-carotene, and beta-cryptoxanthin significant overall differences by ART regimen.

The protease inhibitor (PI) treatment group showed significant levels of three antioxidants comapred to the other three ART groups combined.

In other words, the protease inhibitor (PI) blocked the HIV replication for the production of infectious viral particles by exerting a significant antioxidant effect against oxidative stress levels in HIV-positive IDUs.

Based on the findings, researchers said, "circulating levels of lycopene, a biomarker of tomato-rich food, may play a role in early stages of atherogenesis and may have clinical and public health relevance".

Taken altogether, lycopene found in tomatoes combined with conventional medicine may be considered supplements for the prevention and treatment of HIV infection, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The potential role of lycopene for human health by Gerster H. (PubMed)
(2) Improved antioxidant status among HIV-infected injecting drug users on potent antiretroviral therapy by Tang AM1, Smit E, Semba RD, Shah N, Lyles CM, Li D, Vlahov D. (PubMed)

#BrassicaOleraceaVegetablesJuices Inhibit the Onset of Breast Cancer through Its Anti-Proliferative Activity, Researchers Say

Kyle J. Norton

Cancer is a class of diseases in which a group of cells grow and multiply disorderly and uncontrollably in our body.

The prevalence of breast cancer has been acknowledged in the scientific community worldwide. Breast cancer widespread in women in Southeast Asia as a result of over 2 decades of economic prosperity caused by an unhealthy diet is a major concern.

The women's breasts are made up of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of a woman's breast is totally determined by the amount of fat.

Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.

Most cases of breast cancer start in the cells on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.

Breast cancer is first noticed as a painless lump in the breast or armpit and is most often discovered by the women themselves.

Breast skin irritation or dimpling, nipple pain, nipple retraction (turning inward), redness, and scaliness that cannot be healed within 3 weeks are also the signs and symptoms of breast cancer.

According to statistics, the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

People who inherited the genetic preposition of BRCA1 and 2 are associated with over 60% of the risk of breast cancer.

However, an unhealthy diet and lifestyle are some of the preventable risk factors that form a major cause of breast cancer onset.


In postmenopause, weight control is the major factor throughout life that appears to prevent breast cancer after menopause.

Daily physical activity and reduced intake of alcohol throughout life are associated with reduced risk of developing pre- and postmenopausal breast cancer, however, smoking during adolescence or early adulthood increases later risk of breast cancer.

Interestingly, in the depth discussion of the diet pattern in the risk of breast cancer, researchers do not find a direct link to breast cancer risk.

These results suggested by actively following a healthy lifestyle and moderate exercise, the risk of breast cancer can be decreased substantially.

Kale is a species of Brassica Oleracea, belonging to the family Brassicaceae, native to coastal southern and western Europe. The veggie leaf is highly nutritious and cultivated as a food in most parts of Europe.

In finding a potent compound for the prevention and treatment of cancers, researchers examined the antiproliferative activity of juice obtained from leaves of several varieties of Brassica oleracea on both estrogen receptor (ER)-positive (ER+; MCF-7 and BT474) and ER-negative (ER-; MDA-MB-231 and BT20) human breast cancer cell lines.

At low concentrations to a final concentration 5-15 mL/L,
* All cauliflower varieties tested suppressed cell proliferation in a dose-dependent manner.

* Although no evidence of apoptosis was found, cancer cell growth inhibition was accompanied by significant cell death at the higher juice concentrations.

* All juices showed a preference in the inhibition of breast cancer cells compared with other mammalian cell lines, such as ECV304, VERO, Hep2, 3T3, and MCF-10A.

In the cell levels, all juices exerted the inhibition of proliferation associated with significantly reduced CDK6 expression, and an increased level of p27 involved cell division and cell cycle arrest, respectively, in ER+ cells but not in ER- cells.

Based on the results, researchers said, "the edible part of Brassica oleracea contains substances that can markedly inhibit the growth of both ER+ and ER- human breast cancer cells, although through different mechanisms".

Taken together, kale, a member of cruciferous vegetables may be considered a functional food for the treatment of breast cancer, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Mechanisms of action and antiproliferative properties of Brassica oleracea juice in human breast cancer cell lines by Brandi G1, Schiavano GF, Zaffaroni N, De Marco C, Paiardini M, Cervasi B, Magnani M. (PubMed)

#Phytochemical #Betanin Inhibits the Risk of Acute Kidney Injury Associated with Overexpression of Oxidativestress, Scientists Suggest

Kyle J. Norton

Acute inflammation is a condition that lasts in the short term caused by an immune system response to the injury.
Symptoms of pain, redness, immobility (loss of function), swelling, and heat may occur within minutes or hours, depending on the size and penetration of the wound.

Overproduction of proinflammatory cytokines induced by the immune response may cause damage or death of nearby healthy cells, leading to the formation of scars.

The symptoms may disappear sooner in people with a stronger immune system compared to the elderly and the wound is covered quickly in a few days.


However, if the wound is quite large, then some stitches may be needed and the wound recovery will go through 4 overlapped stages, including

* The stage of hemostasis is the process of the wound being closed by clotting.
* The second stage is involved in the production of inflammatory cytokines in the prevention of infection.
* The third stage is proliferation in which the wound is rebuilt with new tissues made up of collagen and extracellular matrix.
and
* The masturbating stage in which collagens are converted, the recovery is completed, and the wound is fully closed.

Any interruption of the overlapped stage may induce the formation of scars similar to those of overproduction of inflammatory cytokines.

Unfortunately, if the immune system can not kill off all invaders over a short period of time normally between 3 to 8 weeks, it will compromise, leading to chronic inflammation in facilitating several chronic diseases such as cardiovascular disease and diabetes.

Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to discover a potential ingredient for the treatment of diseases associated with inflammation, researchers investigated the effects of the natural pigment betanin on oxidative stress and inflammation in the kidneys of paraquat-treated rats.

Selected rats were injected with Paraquat intraperitoneally to induce renal damage, then randomly divided into four groups: a control group, a paraquat group, and two paraquat groups that were treated with betanin at 25 and 100 mg/kg/d three days before and two days after paraquat administration.

Betanin treated group showed a significant effect in alleviating the paraquat-incurred acute kidney injury, evidenced by histological improvement, reducing serum and urine markers for kidney injury compared to the untreated group.

The bioactive compound also attenuated the inflammation induced by the injection of Paraquat observed by the reduced expression of inflammatory proteins.

Furthermore, betanin also inhibits the kidney's oxidative stress through its antioxidant activity.


Based on the findings, researchers said, "betanin may have a protective effect against paraquat-induced acute kidney damage. The mechanisms of the protection appear to be the inhibition of oxidative stress and inflammation".

Taken altogether, betanin may be considered a supplement for the prevention and treatment of diseases associated with inflammation, pending the confirmation of a larger sample size and multicenter human study.

Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Betanin attenuates oxidative stress and inflammatory reaction in kidneys of paraquat-treated rats by Tan D1, Wang Y2, Bai B1, Yang X2, Han J. (PubMed)
(2) Mechanism of interaction of betanin and indicaxanthin with human myeloperoxidase and hypochlorous acid by Allegra M1, Furtmüller PG, Jantschko W, Zederbauer M, Tesoriere L, Livrea MA, Obinger C. (PubMed)

#Brassicarapa (EBR) Inhibits the Onset of #Cisplatin-induced #Nephrotoxicity Associated with Oxidative stress, Reserachers Show

Kyle J. Norton

Kidneys are 2 bean-shaped organs found on the left and right side of the retroperitoneal space in the body.
The function of the kidneys is to filter blood and control fluids. They are the second detoxed organs besides the liver and skin.

Due to millions of tiny filters called nephrons in each kidney, people may not experience any kidney dysfunction symptoms at an early stage.

Kidney diseases are a class of medical conditions associated with reduced function of the kidney, in cases, complete loss of kidney function such as kidney failure.

Believe it or not, in the US, the leading causes of kidney failure and the end stage of chronic kidney diseases are diabetes and high blood pressure.

Nephrotoxicity or acute kidney failure is a condition of toxicity in the kidneys.

The disease is caused by the poisonous effect of prolonged use of certain medications and the accumulation of harmful chemicals.

According to the American Physician Association, long-term use of penicillins, cephalosporins, sulfonamides, thiazide diuretics, furosemide, NSAIDs, and rifampicin are associated with increased damage to the kidney.

And people aged over 60 are at increased risk of nephrotoxicity if the above medicines are prescribed for prolonged periods.

Oxidative stress is a condition caused by an imbalance of the ratio of free radicals and antioxidants in the body.

In other words, oxidative stress is either caused by overexpression of free radicals or depletion of antioxidant enzymes in the body.

Long-term oxidative stress in the body can cause protein and lipid damage and alternation of cell DNA, leading to chronic diseases, including cardiovascular disease, diabetes, cancer, and nephrotoxicity.

Brassica rapa is a species of plant including turnip, napa cabbage, and bok choy.
On finding a potential plant that protects the kidney against damage, researchers compared the effects of ethanol extract from the roots of Brassica rapa (EBR) on cisplatin-induced nephrotoxicity associated with oxidative stress.

Before treatment with EBR, cisplatin decreased the antioxidant enzyme activity such as glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) in the cells.

Furthermore, A single dose of cisplatin (7 mg/kg, i.p.) causes kidney damage manifested by an elevation in blood urea nitrogen (BUN), serum creatinine, and urine lactate dehydrogenase (LDH) levels and oxidative stress malondialdehyde (MDA) production, and activities of aldehyde oxidase (AO) and xanthine oxidase (XO) in the kidney.

In vitro, LLC-PK1 cells pretreated by EBR prevented cisplatin-induced decreases in cell viability and cellular antioxidant GSH content.

Pretreatment of EBR, not only inhibited all parameters associated with the side effect caused by injection of cisplatin but also protected the kidney against damage induced by oxidative stress.

Based on the experimental results, researchers said, "This extract also recovered the reduced activities of GPx, SOD, and CAT. Taken together, our data indicate that the ethanol extract of the roots of Brassica rapa (EBR) has a protective effect against cisplatin-induced nephrotoxicity because it attenuates oxidative stress".

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effect of the ethanol extract of the roots of Brassica rapa on cisplatin-induced nephrotoxicity in LLC-PK1 cells and rats by Kim YH1, Kim YW, Oh YJ, Back NI, Chung SA, Chung HG, Jeong TS, Choi MS, Lee KT. (PubMed)

#Tomato's #Lycopene, a Non-Provitamin A #Carotenoid, Inhibits the Risk of Non-alcoholic Steatohepatitis NASH, Researchers Say

Kyle J. Norton

Nonalcoholic steatohepatitis (NASH), is a type of inflammatory non-alcoholic fatty liver disease caused by a buildup of fat in the liver.

Most cases of NASH if untreated can lead to liver scars or building up of scars over time, a condition of liver cirrhosis, and one of the most common causes of liver cancer.

Most people with non-inflammatory-alcoholic fatty liver disease are asymptomatic, however, the inflammation caused by non-alcoholic steatohepatitis may induce liver damage, leading to a reduced function of the liver that orchestrates the onset of liver symptoms.

The most common symptoms are abdominal swelling, enlarged blood vessels just beneath the skin's surface, enlarged spleen, red palms, and jaundice.

If you have experienced some of the aforementioned symptoms that do not recede in a short period of time, you may have some forms of liver disease. Please check with your doctor to rule out the possibility.

Out of many prevalent factors associated with increased risk of non-alcoholic steatohepatitis, some researchers suggested the rise of the condition in the US population may be correlated to the promotion of the Western diet over the past few decades.

Dr. H. Cortez-Pinto, the lead scientist said, " Comparison of their diet history with control data (C) revealed that carbohydrate consumption was lower in patients (P): P—243.6±5.7g vs. C—261.5±1.6g, P<0.05, and most patients had very low fiber intake. Conversely, total fat consumption was higher in patients: P—79.7±1.7g vs. 73.0±0.4, P<0.01. A significantly higher intake of n-6 fatty acids (P=0.003) and the then-6/n-3 ratio was found in patients, P<0.001".

And, "Our results suggest that the quality and combination of carbohydrates and fat intake may be more relevant than their isolated amount; an increased fat intake with an excessive amount of n-6 fatty acids can be implicated in promoting necro-inflammation, and provides further grounds for individualized dietary therapy".

Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods for the treatment of liver disease, researchers examined the effect of lycopene, a non-provitamin A carotenoid, and the pigment principally responsible for the characteristic deep-red color of ripe tomato and tomato products on subjects with non-alcoholic steatohepatitis.


According to the review of the epidemiological study, tomato extract supplementation showed a significant protective effect against HFD-induced hepatic inflammation compared to supplementation of lycopene.

In patients with NASH, increased levels of plasma lycopene may have a strong impact on the progression of NASH as patients have been shown to have significantly reduced plasma lycopene.


In vivo, dietary lycopene inhibits liver carcinogen-induced preneoplastic lesions in the rat liver which was effective in reducing NASH-promotion in rats.


The efficacy of lycopene in the inhibition of NASH and another chronic disease may be associated with the body's lycopene metabolism involved in both the chemical and enzymatic modifications.


Furthermore, in vivo synthesis of ACR from lycopene was shown to attenuate hepatic steatosis, by decreasing the macrophage-conditioned medium-induced and TNFα-mediated induction of pro-inflammatory cytokine and chemokines.

Taken together, tomatoes processed with a high amount of lycopene may be considered dietary supplements for the prevention and treatment of NASH, pending to large sample size and multicenter human study.

Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention by Ip BC1, Wang XD. (PubMed)
(2) How different is the dietary pattern in non-alcoholic steatohepatitis patients? by H. Cortez-Pintoa, L. Jesusa, H. Barrosc, C. Lopesc, M.C. Mourab, and M.E. Camiloa. (Clinical Nutrition)

#ManukaHoney (MH) and #TualangHoney (TH) Process a Strong Anti-Bacterial Infection Activity, According to Studies

Kyle J. Norton

Scientists may have found natural alternative antibiotics for the treatment of diseases caused by a bacterial infection, some studies found.

Infection is a medical condition caused by bacteria multiplication after entering the body.

Most bacteria are killed off by the white blood cells of the first line of defense of the immune system before they can enter the body.

In this stage, the immune systematic response stimulates the production of proteins associated with the production of coagulation to seal the wound and damage and pro-inflammatory cytokines to destroy the invaded bacteria, leading to symptoms of fever, and skin redness in the infected area.

However, if they enter the body successfully, they can initiate infection through the stage of incubation where bacteria multiply in the specific tissues and organs, leading to colonization and facilitating disease development.

Patients with acute bacterial infection usually recover in a short period of time within 3 weeks.

Some bacterial pathogens can establish life-long chronic infections in the host by the persistent establishment after an acute infection period.


Dr. Young D, the lead scientist, at the Technology and Medicine, said," Bacteria have evolved specific pathogenic mechanisms and harbor sets of genes that contribute to the establishment of a persistent lifestyle that leads to chronic infection"

" Persistent bacterial infection may involve occupation of a particular tissue type or organ or modification of the intracellular environment within eukaryotic cells".

"Bacteria appear to adapt their immediate environment to favor survival and may hijack essential immunoregulatory mechanisms designed to minimize immune pathology or the inappropriate activation of immune effectors".

These results firmly suggested that if you have a weakened immune system you are at a higher risk to the onset of chronic bacterial infection.


Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.

On finding natural sources as a new antibiotic with no side effects, researchers examine the Manuka honey (MH) antibacterial effect in bioactive wound dressings.
Epidemiological studies suggested that MH provides unique antibacterial activity compared to conventional kinds of honey, due to its constituents, methylglyoxal (MGO).

In the evaluation of the antibacterial activity of both MH and MGO (at equivalent MGO concentrations) when applied as a physical coating to a nonwoven fabric wound dressing, researchers found that* Application of concentrations of 0.0054 mg cm-2 of MGO in the form of MH and MGO is sufficient to achieve a 100 colony-forming unit % bacteria reduction against gram-positive Staphylococcus aureus and gram-negative Klebsiella pneumonia.

* However, a 3- to 20-fold increase in MGO concentration (0.0170-0.1 mg cm-2) was required to facilitate a good antibacterial effect.

These results suggested that Manuka honey antibacterial activity is processed a linearly and MGO concentration-dependent manner.


Dr. Bulman SEL, the lead scientist said, "The results presented in this study, therefore, demonstrate the relevance of an MGO-based coating as an environmentally friendly strategy for the design of functional dressings with antibiotic-free antimicrobial chemistries".

Additionally, in the investigation of the traditional use of Tualang honey (TH) for the treatment of bacterial infection against various microorganisms, including those from burn-related diagnoses, compared the anti-antibacterial activity of Aquacel-Tualang honey, Aquacel-Manuka honey, Aquacel-Ag, and Aquacel- plain dressings against bacteria isolated from patients.

Four types of Gram-negative bacteria, namely Enterobacter cloacae, Klebsiella pneumonia, Pseudomonas spp., and Acinetobacter spp., and three Gram-positive bacteria, namely Staphylococcus aureus, coagulase-negative Staphylococcus aureus (CONS), and Streptococcus spp. were included in the study.

All tested agents showed a significant effect inhibiting the total bacterial count on day 6 and onwards.


Aquacel-Ag and Aquacel-Manuka honey dressings gave a better zone of inhibition for Gram-positive bacteria compared to Aquacel-Tualang honey dressing.

The comparable results were also found in the Aquacel-Manuka honey and Aquacel-Tualang honey dressing against Gram-negative bacteria.

Researchers after taking into account co and confounders suggested that Tualang honey has a bactericidal as well as bacteriostatic effect and is easier to apply and less sticky compared to Manuka honey.

Taken together, there is no doubt that Manuka honey (MH) and Tualang honey (TH) may be considered a functional remedy for the prevention and treatment of bacterial infection. However, before they can be used as antibiotics similar to those of conventional medicine, a larger and multicenter human study is necessary to reconfirm the viability.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Antibacterial Properties of Nonwoven Wound Dressings Coated with Manuka Honey or Methylglyoxal by Bulman SEL1, Tronci G2, Goswami P3, Carr C4, Russell SJ5.(PubMed)
(2) Antibacterial properties of tualang honey and its effect in burn wound management: a comparative study by Nasir NA1, Halim AS, Singh KK, Dorai AA, Haneef MN.(PubMed)
(3) The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey by Tan HT1, Rahman RA, Gan SH, Halim AS, Hassan SA, Sulaiman SA, Kirnpal-Kaur B.(PubMed)
(4) Chronic bacterial infections: living with unwanted guests by Young D1, Hussell T, Dougan G.(PubMed)