Kyle J. Norton
Kidneys are 2 bean-shaped organs found on the left and right side of the retroperitoneal space in the body.
The function of the kidneys is to filter blood and control fluids. They are the second detoxed organs besides the liver and skin.
Due to millions of tiny filters called nephrons in each kidney, people may not experience any kidney dysfunction symptoms at an early stage.
Kidney diseases are a class of medical conditions associated with reduced function of the kidney, in cases, complete loss of kidney function such as kidney failure.
Believe it or not, in the US, the leading causes of kidney failure and the end stage of chronic kidney diseases are diabetes and high blood pressure.
Nephrotoxicity or acute kidney failure is a condition of toxicity in the kidneys.
The disease is caused by the poisonous effect of prolonged use of certain medications and the accumulation of harmful chemicals.
According to the American Physician Association, long-term use of penicillins, cephalosporins, sulfonamides, thiazide diuretics, furosemide, NSAIDs, and rifampicin are associated with increased damage to the kidney.
And people aged over 60 are at increased risk of nephrotoxicity if the above medicines are prescribed for prolonged periods.
Oxidative stress is a condition caused by an imbalance of the ratio of free radicals and antioxidants in the body.
In other words, oxidative stress is either caused by overexpression of free radicals or depletion of antioxidant enzymes in the body.
Long-term oxidative stress in the body can cause protein and lipid damage and alternation of cell DNA, leading to chronic diseases, including cardiovascular disease, diabetes, cancer, and nephrotoxicity.
Brassica rapa is a species of plant including turnip, napa cabbage, and bok choy.
On finding a potential plant that protects the kidney against damage, researchers compared the effects of ethanol extract from the roots of Brassica rapa (EBR) on cisplatin-induced nephrotoxicity associated with oxidative stress.
Before treatment with EBR, cisplatin decreased the antioxidant enzyme activity such as glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) in the cells.
Furthermore, A single dose of cisplatin (7 mg/kg, i.p.) causes kidney damage manifested by an elevation in blood urea nitrogen (BUN), serum creatinine, and urine lactate dehydrogenase (LDH) levels and oxidative stress malondialdehyde (MDA) production, and activities of aldehyde oxidase (AO) and xanthine oxidase (XO) in the kidney.
In vitro, LLC-PK1 cells pretreated by EBR prevented cisplatin-induced decreases in cell viability and cellular antioxidant GSH content.
Pretreatment of EBR, not only inhibited all parameters associated with the side effect caused by injection of cisplatin but also protected the kidney against damage induced by oxidative stress.
Based on the experimental results, researchers said, "This extract also recovered the reduced activities of GPx, SOD, and CAT. Taken together, our data indicate that the ethanol extract of the roots of Brassica rapa (EBR) has a protective effect against cisplatin-induced nephrotoxicity because it attenuates oxidative stress".
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of the ethanol extract of the roots of Brassica rapa on cisplatin-induced nephrotoxicity in LLC-PK1 cells and rats by Kim YH1, Kim YW, Oh YJ, Back NI, Chung SA, Chung HG, Jeong TS, Choi MS, Lee KT. (PubMed)
Tuesday, 5 September 2023
#Tomato's #Lycopene, a Non-Provitamin A #Carotenoid, Inhibits the Risk of Non-alcoholic Steatohepatitis NASH, Researchers Say
Kyle J. Norton
Nonalcoholic steatohepatitis (NASH), is a type of inflammatory non-alcoholic fatty liver disease caused by a buildup of fat in the liver.
Most cases of NASH if untreated can lead to liver scars or building up of scars over time, a condition of liver cirrhosis, and one of the most common causes of liver cancer.
Most people with non-inflammatory-alcoholic fatty liver disease are asymptomatic, however, the inflammation caused by non-alcoholic steatohepatitis may induce liver damage, leading to a reduced function of the liver that orchestrates the onset of liver symptoms.
The most common symptoms are abdominal swelling, enlarged blood vessels just beneath the skin's surface, enlarged spleen, red palms, and jaundice.
If you have experienced some of the aforementioned symptoms that do not recede in a short period of time, you may have some forms of liver disease. Please check with your doctor to rule out the possibility.
Out of many prevalent factors associated with increased risk of non-alcoholic steatohepatitis, some researchers suggested the rise of the condition in the US population may be correlated to the promotion of the Western diet over the past few decades.
Dr. H. Cortez-Pinto, the lead scientist said, " Comparison of their diet history with control data (C) revealed that carbohydrate consumption was lower in patients (P): P—243.6±5.7g vs. C—261.5±1.6g, P<0.05, and most patients had very low fiber intake. Conversely, total fat consumption was higher in patients: P—79.7±1.7g vs. 73.0±0.4, P<0.01. A significantly higher intake of n-6 fatty acids (P=0.003) and the then-6/n-3 ratio was found in patients, P<0.001".
And, "Our results suggest that the quality and combination of carbohydrates and fat intake may be more relevant than their isolated amount; an increased fat intake with an excessive amount of n-6 fatty acids can be implicated in promoting necro-inflammation, and provides further grounds for individualized dietary therapy".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for the treatment of liver disease, researchers examined the effect of lycopene, a non-provitamin A carotenoid, and the pigment principally responsible for the characteristic deep-red color of ripe tomato and tomato products on subjects with non-alcoholic steatohepatitis.
According to the review of the epidemiological study, tomato extract supplementation showed a significant protective effect against HFD-induced hepatic inflammation compared to supplementation of lycopene.
In patients with NASH, increased levels of plasma lycopene may have a strong impact on the progression of NASH as patients have been shown to have significantly reduced plasma lycopene.
In vivo, dietary lycopene inhibits liver carcinogen-induced preneoplastic lesions in the rat liver which was effective in reducing NASH-promotion in rats.
The efficacy of lycopene in the inhibition of NASH and another chronic disease may be associated with the body's lycopene metabolism involved in both the chemical and enzymatic modifications.
Furthermore, in vivo synthesis of ACR from lycopene was shown to attenuate hepatic steatosis, by decreasing the macrophage-conditioned medium-induced and TNFα-mediated induction of pro-inflammatory cytokine and chemokines.
Taken together, tomatoes processed with a high amount of lycopene may be considered dietary supplements for the prevention and treatment of NASH, pending to large sample size and multicenter human study.
Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention by Ip BC1, Wang XD. (PubMed)
(2) How different is the dietary pattern in non-alcoholic steatohepatitis patients? by H. Cortez-Pintoa, L. Jesusa, H. Barrosc, C. Lopesc, M.C. Mourab, and M.E. Camiloa. (Clinical Nutrition)
Nonalcoholic steatohepatitis (NASH), is a type of inflammatory non-alcoholic fatty liver disease caused by a buildup of fat in the liver.
Most cases of NASH if untreated can lead to liver scars or building up of scars over time, a condition of liver cirrhosis, and one of the most common causes of liver cancer.
Most people with non-inflammatory-alcoholic fatty liver disease are asymptomatic, however, the inflammation caused by non-alcoholic steatohepatitis may induce liver damage, leading to a reduced function of the liver that orchestrates the onset of liver symptoms.
The most common symptoms are abdominal swelling, enlarged blood vessels just beneath the skin's surface, enlarged spleen, red palms, and jaundice.
If you have experienced some of the aforementioned symptoms that do not recede in a short period of time, you may have some forms of liver disease. Please check with your doctor to rule out the possibility.
Out of many prevalent factors associated with increased risk of non-alcoholic steatohepatitis, some researchers suggested the rise of the condition in the US population may be correlated to the promotion of the Western diet over the past few decades.
Dr. H. Cortez-Pinto, the lead scientist said, " Comparison of their diet history with control data (C) revealed that carbohydrate consumption was lower in patients (P): P—243.6±5.7g vs. C—261.5±1.6g, P<0.05, and most patients had very low fiber intake. Conversely, total fat consumption was higher in patients: P—79.7±1.7g vs. 73.0±0.4, P<0.01. A significantly higher intake of n-6 fatty acids (P=0.003) and the then-6/n-3 ratio was found in patients, P<0.001".
And, "Our results suggest that the quality and combination of carbohydrates and fat intake may be more relevant than their isolated amount; an increased fat intake with an excessive amount of n-6 fatty acids can be implicated in promoting necro-inflammation, and provides further grounds for individualized dietary therapy".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for the treatment of liver disease, researchers examined the effect of lycopene, a non-provitamin A carotenoid, and the pigment principally responsible for the characteristic deep-red color of ripe tomato and tomato products on subjects with non-alcoholic steatohepatitis.
According to the review of the epidemiological study, tomato extract supplementation showed a significant protective effect against HFD-induced hepatic inflammation compared to supplementation of lycopene.
In patients with NASH, increased levels of plasma lycopene may have a strong impact on the progression of NASH as patients have been shown to have significantly reduced plasma lycopene.
In vivo, dietary lycopene inhibits liver carcinogen-induced preneoplastic lesions in the rat liver which was effective in reducing NASH-promotion in rats.
The efficacy of lycopene in the inhibition of NASH and another chronic disease may be associated with the body's lycopene metabolism involved in both the chemical and enzymatic modifications.
Furthermore, in vivo synthesis of ACR from lycopene was shown to attenuate hepatic steatosis, by decreasing the macrophage-conditioned medium-induced and TNFα-mediated induction of pro-inflammatory cytokine and chemokines.
Taken together, tomatoes processed with a high amount of lycopene may be considered dietary supplements for the prevention and treatment of NASH, pending to large sample size and multicenter human study.
Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention by Ip BC1, Wang XD. (PubMed)
(2) How different is the dietary pattern in non-alcoholic steatohepatitis patients? by H. Cortez-Pintoa, L. Jesusa, H. Barrosc, C. Lopesc, M.C. Mourab, and M.E. Camiloa. (Clinical Nutrition)
#ManukaHoney (MH) and #TualangHoney (TH) Process a Strong Anti-Bacterial Infection Activity, According to Studies
Kyle J. Norton
Scientists may have found natural alternative antibiotics for the treatment of diseases caused by a bacterial infection, some studies found.
Infection is a medical condition caused by bacteria multiplication after entering the body.
Most bacteria are killed off by the white blood cells of the first line of defense of the immune system before they can enter the body.
In this stage, the immune systematic response stimulates the production of proteins associated with the production of coagulation to seal the wound and damage and pro-inflammatory cytokines to destroy the invaded bacteria, leading to symptoms of fever, and skin redness in the infected area.
However, if they enter the body successfully, they can initiate infection through the stage of incubation where bacteria multiply in the specific tissues and organs, leading to colonization and facilitating disease development.
Patients with acute bacterial infection usually recover in a short period of time within 3 weeks.
Some bacterial pathogens can establish life-long chronic infections in the host by the persistent establishment after an acute infection period.
Dr. Young D, the lead scientist, at the Technology and Medicine, said," Bacteria have evolved specific pathogenic mechanisms and harbor sets of genes that contribute to the establishment of a persistent lifestyle that leads to chronic infection"
" Persistent bacterial infection may involve occupation of a particular tissue type or organ or modification of the intracellular environment within eukaryotic cells".
"Bacteria appear to adapt their immediate environment to favor survival and may hijack essential immunoregulatory mechanisms designed to minimize immune pathology or the inappropriate activation of immune effectors".
These results firmly suggested that if you have a weakened immune system you are at a higher risk to the onset of chronic bacterial infection.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.
On finding natural sources as a new antibiotic with no side effects, researchers examine the Manuka honey (MH) antibacterial effect in bioactive wound dressings.
Epidemiological studies suggested that MH provides unique antibacterial activity compared to conventional kinds of honey, due to its constituents, methylglyoxal (MGO).
In the evaluation of the antibacterial activity of both MH and MGO (at equivalent MGO concentrations) when applied as a physical coating to a nonwoven fabric wound dressing, researchers found that* Application of concentrations of 0.0054 mg cm-2 of MGO in the form of MH and MGO is sufficient to achieve a 100 colony-forming unit % bacteria reduction against gram-positive Staphylococcus aureus and gram-negative Klebsiella pneumonia.
* However, a 3- to 20-fold increase in MGO concentration (0.0170-0.1 mg cm-2) was required to facilitate a good antibacterial effect.
These results suggested that Manuka honey antibacterial activity is processed a linearly and MGO concentration-dependent manner.
Dr. Bulman SEL, the lead scientist said, "The results presented in this study, therefore, demonstrate the relevance of an MGO-based coating as an environmentally friendly strategy for the design of functional dressings with antibiotic-free antimicrobial chemistries".
Additionally, in the investigation of the traditional use of Tualang honey (TH) for the treatment of bacterial infection against various microorganisms, including those from burn-related diagnoses, compared the anti-antibacterial activity of Aquacel-Tualang honey, Aquacel-Manuka honey, Aquacel-Ag, and Aquacel- plain dressings against bacteria isolated from patients.
Four types of Gram-negative bacteria, namely Enterobacter cloacae, Klebsiella pneumonia, Pseudomonas spp., and Acinetobacter spp., and three Gram-positive bacteria, namely Staphylococcus aureus, coagulase-negative Staphylococcus aureus (CONS), and Streptococcus spp. were included in the study.
All tested agents showed a significant effect inhibiting the total bacterial count on day 6 and onwards.
Aquacel-Ag and Aquacel-Manuka honey dressings gave a better zone of inhibition for Gram-positive bacteria compared to Aquacel-Tualang honey dressing.
The comparable results were also found in the Aquacel-Manuka honey and Aquacel-Tualang honey dressing against Gram-negative bacteria.
Researchers after taking into account co and confounders suggested that Tualang honey has a bactericidal as well as bacteriostatic effect and is easier to apply and less sticky compared to Manuka honey.
Taken together, there is no doubt that Manuka honey (MH) and Tualang honey (TH) may be considered a functional remedy for the prevention and treatment of bacterial infection. However, before they can be used as antibiotics similar to those of conventional medicine, a larger and multicenter human study is necessary to reconfirm the viability.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antibacterial Properties of Nonwoven Wound Dressings Coated with Manuka Honey or Methylglyoxal by Bulman SEL1, Tronci G2, Goswami P3, Carr C4, Russell SJ5.(PubMed)
(2) Antibacterial properties of tualang honey and its effect in burn wound management: a comparative study by Nasir NA1, Halim AS, Singh KK, Dorai AA, Haneef MN.(PubMed)
(3) The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey by Tan HT1, Rahman RA, Gan SH, Halim AS, Hassan SA, Sulaiman SA, Kirnpal-Kaur B.(PubMed)
(4) Chronic bacterial infections: living with unwanted guests by Young D1, Hussell T, Dougan G.(PubMed)
Scientists may have found natural alternative antibiotics for the treatment of diseases caused by a bacterial infection, some studies found.
Infection is a medical condition caused by bacteria multiplication after entering the body.
Most bacteria are killed off by the white blood cells of the first line of defense of the immune system before they can enter the body.
In this stage, the immune systematic response stimulates the production of proteins associated with the production of coagulation to seal the wound and damage and pro-inflammatory cytokines to destroy the invaded bacteria, leading to symptoms of fever, and skin redness in the infected area.
However, if they enter the body successfully, they can initiate infection through the stage of incubation where bacteria multiply in the specific tissues and organs, leading to colonization and facilitating disease development.
Patients with acute bacterial infection usually recover in a short period of time within 3 weeks.
Some bacterial pathogens can establish life-long chronic infections in the host by the persistent establishment after an acute infection period.
Dr. Young D, the lead scientist, at the Technology and Medicine, said," Bacteria have evolved specific pathogenic mechanisms and harbor sets of genes that contribute to the establishment of a persistent lifestyle that leads to chronic infection"
" Persistent bacterial infection may involve occupation of a particular tissue type or organ or modification of the intracellular environment within eukaryotic cells".
"Bacteria appear to adapt their immediate environment to favor survival and may hijack essential immunoregulatory mechanisms designed to minimize immune pathology or the inappropriate activation of immune effectors".
These results firmly suggested that if you have a weakened immune system you are at a higher risk to the onset of chronic bacterial infection.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered of healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.
On finding natural sources as a new antibiotic with no side effects, researchers examine the Manuka honey (MH) antibacterial effect in bioactive wound dressings.
Epidemiological studies suggested that MH provides unique antibacterial activity compared to conventional kinds of honey, due to its constituents, methylglyoxal (MGO).
In the evaluation of the antibacterial activity of both MH and MGO (at equivalent MGO concentrations) when applied as a physical coating to a nonwoven fabric wound dressing, researchers found that* Application of concentrations of 0.0054 mg cm-2 of MGO in the form of MH and MGO is sufficient to achieve a 100 colony-forming unit % bacteria reduction against gram-positive Staphylococcus aureus and gram-negative Klebsiella pneumonia.
* However, a 3- to 20-fold increase in MGO concentration (0.0170-0.1 mg cm-2) was required to facilitate a good antibacterial effect.
These results suggested that Manuka honey antibacterial activity is processed a linearly and MGO concentration-dependent manner.
Dr. Bulman SEL, the lead scientist said, "The results presented in this study, therefore, demonstrate the relevance of an MGO-based coating as an environmentally friendly strategy for the design of functional dressings with antibiotic-free antimicrobial chemistries".
Additionally, in the investigation of the traditional use of Tualang honey (TH) for the treatment of bacterial infection against various microorganisms, including those from burn-related diagnoses, compared the anti-antibacterial activity of Aquacel-Tualang honey, Aquacel-Manuka honey, Aquacel-Ag, and Aquacel- plain dressings against bacteria isolated from patients.
Four types of Gram-negative bacteria, namely Enterobacter cloacae, Klebsiella pneumonia, Pseudomonas spp., and Acinetobacter spp., and three Gram-positive bacteria, namely Staphylococcus aureus, coagulase-negative Staphylococcus aureus (CONS), and Streptococcus spp. were included in the study.
All tested agents showed a significant effect inhibiting the total bacterial count on day 6 and onwards.
Aquacel-Ag and Aquacel-Manuka honey dressings gave a better zone of inhibition for Gram-positive bacteria compared to Aquacel-Tualang honey dressing.
The comparable results were also found in the Aquacel-Manuka honey and Aquacel-Tualang honey dressing against Gram-negative bacteria.
Researchers after taking into account co and confounders suggested that Tualang honey has a bactericidal as well as bacteriostatic effect and is easier to apply and less sticky compared to Manuka honey.
Taken together, there is no doubt that Manuka honey (MH) and Tualang honey (TH) may be considered a functional remedy for the prevention and treatment of bacterial infection. However, before they can be used as antibiotics similar to those of conventional medicine, a larger and multicenter human study is necessary to reconfirm the viability.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antibacterial Properties of Nonwoven Wound Dressings Coated with Manuka Honey or Methylglyoxal by Bulman SEL1, Tronci G2, Goswami P3, Carr C4, Russell SJ5.(PubMed)
(2) Antibacterial properties of tualang honey and its effect in burn wound management: a comparative study by Nasir NA1, Halim AS, Singh KK, Dorai AA, Haneef MN.(PubMed)
(3) The antibacterial properties of Malaysian tualang honey against wound and enteric microorganisms in comparison to manuka honey by Tan HT1, Rahman RA, Gan SH, Halim AS, Hassan SA, Sulaiman SA, Kirnpal-Kaur B.(PubMed)
(4) Chronic bacterial infections: living with unwanted guests by Young D1, Hussell T, Dougan G.(PubMed)
Monday, 4 September 2023
#Sinigrin Inhibits Parameters Associated with #FungalInfection, Scientists Say
Kyle J. Norton
The bioactive compound Sinigrin may be used as antibiotic for the treatment of fungal infection, studies suggested.
Antibiotics are conventional medicines used for the treatment of microbial infections except for viruses.
Fungi are a kind of living organism, including molds, molds, and mushrooms.
Most cases of fungal infections start in the lungs or on the skin. People with a weakened immune system or long-term use of antibiotics and immune-suppressive medicine are prone to getting a fungal infection.
Histoplasmosis, which is the most common fungal infection in the US, is caused by the dimorphic fungus Histoplasma capsulatum var. capsulatum.
However, invasive candidiasis is a common infection, approximately 46,000 cases of invasive candidiasis are diagnosed in the US each year.
Believe it or not, there are millions of different fungal species on the Earth, but only about 300 of those make people sick.
Most cases of fungal infection are treated with antibiotics topically or orally.
The untreated fungal infection may cause the spread of fungi to the bloodstream, leading to serious complications including death depending on type of fungal infection.
Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Researchers with an aim to find a natural ingredient used by traditional medicine for the treatment of fungal infection investigated the effect of sinigrin in the form of isothiocyanates (ITCs)against Alternaria brassicicola.
Exposure of the fungus to ICTs led to apoptosis through the decreased oxygen consumption rate, intracellular accumulation of reactive oxygen species (ROS), and mitochondrial membrane depolarization.
The effects of fungal-induced infection on the activation of the mitogen-activated protein (MAP) kinase signaling pathway involved in directing cellular responses to a diverse array of stimuli, were inhibited by the presence of ICTs.
The injection of ICTs also induced the expression of oxygen-reactive species in killing the fungi through cytotoxicity.
However, ICT-derived ROS was also countered by the expression of different oxidative-response genes stimulated by the Alternaria brassicicola.
The findings strongly suggested that ITCs exert their toxicity on fungal cells.
Taken together, sinigrin in the form of isothiocyanates (ITCs) may be considered a supplement for the prevention and treatment of fungal infection, pending the confirmation of a larger sample size and multicenter human study.
Intake of sinigrin as a supplement should be taken with extreme care to prevent overdose-induced liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Glucosinolate-derived isothiocyanates impact mitochondrial function in fungal cells and elicit an oxidative stress response necessary for growth recovery by Benoit Calmes,1,† Guillaume N’Guyen,1,† Jérome Dumur,1 Carlos A. Brisach,1Claire Campion,1 Béatrice Iacomi,2 Sandrine Pigné,2 Eva Dias,1 David Macherel,1Thomas Guillemette,1 and Philippe Simoneau. (PMC)
The bioactive compound Sinigrin may be used as antibiotic for the treatment of fungal infection, studies suggested.
Antibiotics are conventional medicines used for the treatment of microbial infections except for viruses.
Fungi are a kind of living organism, including molds, molds, and mushrooms.
Most cases of fungal infections start in the lungs or on the skin. People with a weakened immune system or long-term use of antibiotics and immune-suppressive medicine are prone to getting a fungal infection.
Histoplasmosis, which is the most common fungal infection in the US, is caused by the dimorphic fungus Histoplasma capsulatum var. capsulatum.
However, invasive candidiasis is a common infection, approximately 46,000 cases of invasive candidiasis are diagnosed in the US each year.
Believe it or not, there are millions of different fungal species on the Earth, but only about 300 of those make people sick.
Most cases of fungal infection are treated with antibiotics topically or orally.
The untreated fungal infection may cause the spread of fungi to the bloodstream, leading to serious complications including death depending on type of fungal infection.
Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Researchers with an aim to find a natural ingredient used by traditional medicine for the treatment of fungal infection investigated the effect of sinigrin in the form of isothiocyanates (ITCs)against Alternaria brassicicola.
Exposure of the fungus to ICTs led to apoptosis through the decreased oxygen consumption rate, intracellular accumulation of reactive oxygen species (ROS), and mitochondrial membrane depolarization.
The effects of fungal-induced infection on the activation of the mitogen-activated protein (MAP) kinase signaling pathway involved in directing cellular responses to a diverse array of stimuli, were inhibited by the presence of ICTs.
The injection of ICTs also induced the expression of oxygen-reactive species in killing the fungi through cytotoxicity.
However, ICT-derived ROS was also countered by the expression of different oxidative-response genes stimulated by the Alternaria brassicicola.
The findings strongly suggested that ITCs exert their toxicity on fungal cells.
Taken together, sinigrin in the form of isothiocyanates (ITCs) may be considered a supplement for the prevention and treatment of fungal infection, pending the confirmation of a larger sample size and multicenter human study.
Intake of sinigrin as a supplement should be taken with extreme care to prevent overdose-induced liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Glucosinolate-derived isothiocyanates impact mitochondrial function in fungal cells and elicit an oxidative stress response necessary for growth recovery by Benoit Calmes,1,† Guillaume N’Guyen,1,† Jérome Dumur,1 Carlos A. Brisach,1Claire Campion,1 Béatrice Iacomi,2 Sandrine Pigné,2 Eva Dias,1 David Macherel,1Thomas Guillemette,1 and Philippe Simoneau. (PMC)
#Cucurbitacin B Found in #Cuccumber Inhibits Non Small Lung Cancer Cells through G2/M Cell-Cycle Arrest and Mitochondrial Apoptosis
Kyle J. Norton
Lung cancer is a medical condition that causes abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells.
Non-small lung cancer is the most common type of lung cancer that accounts for 80% to 85% of all cases of lung cancers, usually grows and spreads methodically and predictably.
The most common types of lung cancers include
* Squamous-cell carcinoma often found in an outer area of the lung
* Large-cell carcinoma found in the center of the lung by an air tube
* Adenocarcinoma is found in any part of the lung.
According to the statistics provided by the American Cancer Society, lung cancer is a leading cause of death among both men and women. Most people diagnosed with lung cancer are 65 or older, compared to a very small number of people diagnosed who are younger than 45.
The most common prevalent factors of non-small cell lung cancer include
1. Smoking
Smoking is a major cause of lung cancer by enhancing oxidation stress by combining the inhaled air with cancer-causing chemical substances (carcinogens) in the cigarette.
Normally, our body can withstand and repair this damage, but prolonged exposure your lung to these dangerous carcinogens can result in lung cancer development.
2. Second-hand smoke
Prolonged exposure to second-hand smoke can also increase the risk of lung cancer.
3. Exposure to certain chemicals
There is an increased risk of lung cancer for people who inhale or are exposed to certain industrial chemicals such as radon gas, arsenic, chromium, nickel, etc. in the workplace.
4. Family history
The risk of lung cancer increases if one of the members of your direct family has lung cancer.
5. Lung disease
The risk of ling can caner increase if you have or previously had certain types of lung disease
6. Excessive drinking
According to the study by Freudenheim et al., R. Curtis Ellison MD suggested that alcohol intake of more than 2 drinks per day is associated with a small increased risk of lung cancer. This study, like others, suggests a weak, positive association with consuming larger amounts of alcohol (>2 drinks a day) and lung cancer risk.
Out of many risk factors, some researchers aging may be one of the major condition as most patients with lung cancer was diagnosed at the age of 65 and over.
Dr. Federico Venuta, the lead researcher wrote, "The respiratory system undergoes a number of structural, physiological, and immunological changes with age. For this reason, at this stage of our life, it is not always easy to differentiate disease from a normal state".
, "From the epidemiological point of view, early-stage lung cancer is observed more frequently in elderly patients; in fact, stage I disease increases from 79% in patients younger than 65 years to 87% in those above 75 years (25). Also, resectability obviously increases with age (1,26): from 15.3% in those younger than 54 years to 25% above 75 years".
The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural and potential compound for the treatment of non-small lung cancer (NSCLC) with no side effects, researchers investigated Cucurbitacin B (CuB), a natural compound isolated from cucumber and other vegetables anti-NSCLC in vitro.
Four NSCLC cells (H1299, A549, HCC-827, and H661) in vitro and the highly aggressive H1299 xenograft in vivo were included in the study.
According to the tested assays, CuB significantly induced G2/M cell-cycle arrest and mitochondrial apoptosis.
Injection by the thiol antioxidant N-acetylcysteine (NAC) in the experiment showed to attenuate all cellular effects of CuB completely.
Interestingly, pretreatment with glutathione synthesis inhibitor glutathione-sulfoxide (BSO), significantly exacerbated CuB's cytotoxic effects against the tested cancer cells in both vitro and vivo.
Further analysis of the anti-NSCLC efficacy of CuB, researchers found that CuB induces cell death via rapidly and significantly decrease the levels of protein thiols and GSH/GSSG ratio by disrupting cellular redox balance induced cytotoxicity.
Dr. Kausar H, the lead scientist said, "CuB interacts with and modulates cellular thiols to mediate its anti-cancer effects. Collectively, our data shed new light on the working mechanisms of CuB and demonstrate its therapeutic potential against NSCLC".
Furthermore, CuB also exerted anti-NSCLC in vitro and vivo CuB by exhibiting a strong anti-migratory and anti-invasive ability against metastatic NSCLC at nanomolar concentrations.
In other words, CuB showed significant tumor angiogenesis-inhibitory effects by the inhibition of migratory, invasive, and tube-forming capacities of human umbilical vein endothelial cells.
Moreover, in experimental EMT model CuB also suppressed the overexpression of protein associated with the production of proinflammatory cytokines in the initiation of cellular change and Wnt/β-catenin signaling axis in stimulating the production of formation of new blood vessels to facilitate cancer proliferation.
Taken altogether, cucumber processed with a high amount of CuB may be considered supplements for the prevention and treatment of non-small cell lung cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets by Kausar H1, Munagala R, Bansal SS, Aqil F, Vadhanam MV, Gupta RC. (PubMed)
(2) Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis by Shukla S1, Sinha S1, Khan S1, Kumar S2, Singh K3, Mitra K3, Maurya R2, Meeran SM. (PubMed)
(3) Lung cancer in elderly patients by Federico Venuta,
Daniele Diso, Ilaria Onorati, Marco Anile, Sara Mantovani, and Erino A. Rendina. (PMC)
Lung cancer is a medical condition that causes abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells.
Non-small lung cancer is the most common type of lung cancer that accounts for 80% to 85% of all cases of lung cancers, usually grows and spreads methodically and predictably.
The most common types of lung cancers include
* Squamous-cell carcinoma often found in an outer area of the lung
* Large-cell carcinoma found in the center of the lung by an air tube
* Adenocarcinoma is found in any part of the lung.
According to the statistics provided by the American Cancer Society, lung cancer is a leading cause of death among both men and women. Most people diagnosed with lung cancer are 65 or older, compared to a very small number of people diagnosed who are younger than 45.
The most common prevalent factors of non-small cell lung cancer include
1. Smoking
Smoking is a major cause of lung cancer by enhancing oxidation stress by combining the inhaled air with cancer-causing chemical substances (carcinogens) in the cigarette.
Normally, our body can withstand and repair this damage, but prolonged exposure your lung to these dangerous carcinogens can result in lung cancer development.
2. Second-hand smoke
Prolonged exposure to second-hand smoke can also increase the risk of lung cancer.
3. Exposure to certain chemicals
There is an increased risk of lung cancer for people who inhale or are exposed to certain industrial chemicals such as radon gas, arsenic, chromium, nickel, etc. in the workplace.
4. Family history
The risk of lung cancer increases if one of the members of your direct family has lung cancer.
5. Lung disease
The risk of ling can caner increase if you have or previously had certain types of lung disease
6. Excessive drinking
According to the study by Freudenheim et al., R. Curtis Ellison MD suggested that alcohol intake of more than 2 drinks per day is associated with a small increased risk of lung cancer. This study, like others, suggests a weak, positive association with consuming larger amounts of alcohol (>2 drinks a day) and lung cancer risk.
Out of many risk factors, some researchers aging may be one of the major condition as most patients with lung cancer was diagnosed at the age of 65 and over.
Dr. Federico Venuta, the lead researcher wrote, "The respiratory system undergoes a number of structural, physiological, and immunological changes with age. For this reason, at this stage of our life, it is not always easy to differentiate disease from a normal state".
, "From the epidemiological point of view, early-stage lung cancer is observed more frequently in elderly patients; in fact, stage I disease increases from 79% in patients younger than 65 years to 87% in those above 75 years (25). Also, resectability obviously increases with age (1,26): from 15.3% in those younger than 54 years to 25% above 75 years".
The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural and potential compound for the treatment of non-small lung cancer (NSCLC) with no side effects, researchers investigated Cucurbitacin B (CuB), a natural compound isolated from cucumber and other vegetables anti-NSCLC in vitro.
Four NSCLC cells (H1299, A549, HCC-827, and H661) in vitro and the highly aggressive H1299 xenograft in vivo were included in the study.
According to the tested assays, CuB significantly induced G2/M cell-cycle arrest and mitochondrial apoptosis.
Injection by the thiol antioxidant N-acetylcysteine (NAC) in the experiment showed to attenuate all cellular effects of CuB completely.
Interestingly, pretreatment with glutathione synthesis inhibitor glutathione-sulfoxide (BSO), significantly exacerbated CuB's cytotoxic effects against the tested cancer cells in both vitro and vivo.
Further analysis of the anti-NSCLC efficacy of CuB, researchers found that CuB induces cell death via rapidly and significantly decrease the levels of protein thiols and GSH/GSSG ratio by disrupting cellular redox balance induced cytotoxicity.
Dr. Kausar H, the lead scientist said, "CuB interacts with and modulates cellular thiols to mediate its anti-cancer effects. Collectively, our data shed new light on the working mechanisms of CuB and demonstrate its therapeutic potential against NSCLC".
Furthermore, CuB also exerted anti-NSCLC in vitro and vivo CuB by exhibiting a strong anti-migratory and anti-invasive ability against metastatic NSCLC at nanomolar concentrations.
In other words, CuB showed significant tumor angiogenesis-inhibitory effects by the inhibition of migratory, invasive, and tube-forming capacities of human umbilical vein endothelial cells.
Moreover, in experimental EMT model CuB also suppressed the overexpression of protein associated with the production of proinflammatory cytokines in the initiation of cellular change and Wnt/β-catenin signaling axis in stimulating the production of formation of new blood vessels to facilitate cancer proliferation.
Taken altogether, cucumber processed with a high amount of CuB may be considered supplements for the prevention and treatment of non-small cell lung cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets by Kausar H1, Munagala R, Bansal SS, Aqil F, Vadhanam MV, Gupta RC. (PubMed)
(2) Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis by Shukla S1, Sinha S1, Khan S1, Kumar S2, Singh K3, Mitra K3, Maurya R2, Meeran SM. (PubMed)
(3) Lung cancer in elderly patients by Federico Venuta,
Daniele Diso, Ilaria Onorati, Marco Anile, Sara Mantovani, and Erino A. Rendina. (PMC)
#Fennel #Extract Processes Cyto-Protection and Antitumor Activity By Inhibiting the Onset of Oxidativestress, Researchers Reveal
Kyle J. Norton
Fennel may have a potential and positive effect that induces cytoprotection and antitumor activity against cancer expression, scientists suggested.
The results of fennel efficacy were reported by several respectable institutes including the National Cancer Institute and the National Institute of Health.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the study to evaluate the efficacy of fennel seed methanolic extract (FSME) for its antioxidant, cytotoxic, and antitumor activities and for its capacity to serve as a nontoxic radioprotector in Swiss albino mice through injection of FSME, 100 mg/kg intraperitoneally into mice bearing EAC before exposed to three 2-Gy doses of gamma irradiation, researchers found at after 30 days, the application exerted a strong effect at the C50 (mean standard deviation 50% inhibitory concentrations) at a dose of 50 μg/mL for the MCF7 breast cancer cell line and 48 μg/mL for the Hepg-2 liver cancer cell line.
The treatment group also displayed a decreased level of MDA and improved natural antioxidants produced by the tissues of the host compared to the elevation of MDA and significantly reduced levels of catalase and GSH contents.
These results suggested that fennel seed methanolic extract (FSME) inhibited the overproduction of ROS caused by ingestion of doses of gamma irradiation through its antioxidant and enhanced antioxidant production of the mice tissue via the ratio of ROS and Antioxidants.
In other words, the application of the fennel extract may have the potential in
* Reduced oxidative stress and protected mouse cells from damage caused by reactive oxygen species.
* Improved natural antioxidants and the oxidative stability of fatty foods during storage.
* Exhibited an antitumor effect by modulating lipid peroxidation and augmenting the antioxidant defense system in EAC-bearing mice with or without exposure to radiation.
Further illustration of the effect of herbal medicine in treatment of cancers and examine the cytoprotective effects, researchers at the National Institute of Health conducted a comparison of five herbal supplements, designated FB, FM, PP, HF, and FBL101, which contain different combinations of various natural herbs such as licorice, black cohosh, Dong Quai, false unicorn and vitex berry root against mice bearing CWR22R and PC3 prostate cancer xenografts.
According to the results of the experiment,
* All herbal medicine, FB, FM, PP, HF, and FBL101 inhibited PC3 tumor growth by 53%, 75%, 80%, 81%, and 87%, respectively.
* In CWR22R tumors, applications of supplements exerted a similar effect in suppressing the cancer cells.
* All applications did not show inhibitory activity against levels of testosterone compared to untreated mice. However, supplements PP and FBL101 exerted significantly reduced VEGF levels, a potent angiogenic factor with function in stimulated production of new blood vessels to ensure cell proliferation, in PC3 and CWR22R tumors.
* Intratumoral microvessel density was decreased in PC3 tumors treated with all five supplements but only in CWR22R tumors treated with HF.
Dr. Ng SS, the lead author said, "Herbal supplements containing the aforementioned extracts inhibit the growth of prostate tumor xenografts, possibly in part by antiangiogenic mechanisms".
The above differentiation was supported by Quaid-i-Azam University in the analysis of the antibacterial potential of some medicinal plants against multi-drug resistant (MDR) pathogens and anticancer effect against the MCF-7 cell line.
According to the results of the report, the application of Ethanol extract of Foeniculum vulgare exhibited significant inhibition of cancer cell proliferation and induction of cancer cell apoptosis and reduction of growth of Klebsiella pneumonia, Serratia marcescens, and Methicillin-resistant S. aureus. Pseudomonas aeruginosa
Taken together, fennel and its extracts may be used as a functional food in the exertion of cytoprotection and antitumor activity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Antioxidant and anticarcinogenic effects of methanolic extract and volatile oil of fennel seeds (Foeniculum vulgare) by Mohamad RH1, El-Bastawesy AM, Abdel-Monem MG, Noor AM, Al-Mehdar HA, Sharawy SM, El-Merzabani MM. (PubMed)
(2) Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice by Ng SS1, Figg WD. (PubMed)
(3) Study of anticancer and antibacterial activities of Foeniculum vulgare, Justicia adhatoda, and Urtica dioica as natural curatives by Batool R1, Salahuddin H1, Mahmood T1, Ismail M2. (PubMed)
#Phytochemical #Betanin Inhibits Diseases Associated with Oxidative Stress, Researchers Say
Kyle J. Norton
Oxidative stress is a condition caused by an imbalance of the ratio of free radicals and antioxidants in the body.
In other words, oxidative stress is either caused by overexpression of free radicals or depletion of antioxidant enzymes in the body.
Some researchers suggested that oxidative stress may also arise due to the chain reaction of free radicals in which free radicals donate or intercept an electron from other stable molecules.
Long-term oxidative stress present in the body can cause protein and lipid damage and alternation of cell DNA, leading to the onset of chronic diseases, including cardiovascular disease, diabetes, and cancer.
More precisely, exogenous factors, such as cigarette smoke, and endogenous factors, such as the oxidative burst from activated macrophages are some of the factors involved in the risk of oxidative stress.
The Liver Pathophysiology, 2017 in the explanation of the cause of oxidative stress, wrote, " (1) the presence of xenobiotics, (2) the activation of the immune system in response to invading microorganisms (inflammation), and (3) radiation, which makes oxidative stress a common denominator of toxicity or stress".
In other words, oxidative stress may be preventable by following a diet rich in antioxidants such as a diet with higher fruit and vegetable consumption accompanied by moderate exercise and reduced intake of saturated and trans fat and processed foods.
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the prevention of diseases associated with oxidative stress, researchers examined the effects of natural pigment betanin on oxidative stress in the kidney of paraquat-treated rats.
Paraquat injected intraperitoneally induced renal damage rats were randomly divided into four groups: a control group, a paraquat group, and two paraquat groups that were treated with betanin at 25 and 100 mg/kg/d three days before and two days after paraquat administration.
Betanin-treated rats showed strong activity in alleviating the paraquat-incurred acute kidney injury, observed by the improvement, and reduced serum and urine markers that indicate a kidney injury.
Betanin also decreased oxidative stress elicited by paraquat by increasing the expression of antioxidant enzymes produced by the host accompanied by inhibiting the levels of free radicals.
These results suggested that betanin protects the tested rats against kidney damage due to oxidative stress in the induction of chronic inflammation.
In streptozotocin (STZ) induced diabetes (DN) in rats, researchers examined the betanin anti-fibrotic mechanisms in rat kidneys.
Betanin at a dose of 25, 50 and 100mg/kg/day and lisinopril (5mg/kg/day, reference compound) orally administered for 8 weeks after the induction of DN, not only significantly inhibited proteinuria, blood glucose, serum creatinine and blood urea nitrogen (BUN) levels involved in kidney injury, but also restored antioxidant enzyme activities in kidney tissue.
Additionally, betanin treatment also protects kidney integrity by reducing the glomerular surface area, glomerulosclerosis, and tubulointerstitial fibrosis.
In other words, betanin demonstrated the kidney protective activity against streptozotocin (STZ) induced diabetes (DN) in rats through regulation of transforming growth factor beta (TGF-β) in facilitating anti-oxidative and anti-inflammatory activity.
Taken altogether, betanin may be considered a supplement for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat by Tan D1, Wang Y2, Bai B1, Yang X2, Han J. (PubMed)
(2) Betanin, isolated from fruits of Opuntia elatior Mill attenuates renal fibrosis in diabetic rats through regulating oxidative stress and TGF-β pathway by Sutariya B1, Saraf M2.(PubMed)
(3) Oxidative Stress, From Liver Pathophysiology, 2017. (Science Direct)
Oxidative stress is a condition caused by an imbalance of the ratio of free radicals and antioxidants in the body.
In other words, oxidative stress is either caused by overexpression of free radicals or depletion of antioxidant enzymes in the body.
Some researchers suggested that oxidative stress may also arise due to the chain reaction of free radicals in which free radicals donate or intercept an electron from other stable molecules.
Long-term oxidative stress present in the body can cause protein and lipid damage and alternation of cell DNA, leading to the onset of chronic diseases, including cardiovascular disease, diabetes, and cancer.
More precisely, exogenous factors, such as cigarette smoke, and endogenous factors, such as the oxidative burst from activated macrophages are some of the factors involved in the risk of oxidative stress.
The Liver Pathophysiology, 2017 in the explanation of the cause of oxidative stress, wrote, " (1) the presence of xenobiotics, (2) the activation of the immune system in response to invading microorganisms (inflammation), and (3) radiation, which makes oxidative stress a common denominator of toxicity or stress".
In other words, oxidative stress may be preventable by following a diet rich in antioxidants such as a diet with higher fruit and vegetable consumption accompanied by moderate exercise and reduced intake of saturated and trans fat and processed foods.
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the prevention of diseases associated with oxidative stress, researchers examined the effects of natural pigment betanin on oxidative stress in the kidney of paraquat-treated rats.
Paraquat injected intraperitoneally induced renal damage rats were randomly divided into four groups: a control group, a paraquat group, and two paraquat groups that were treated with betanin at 25 and 100 mg/kg/d three days before and two days after paraquat administration.
Betanin-treated rats showed strong activity in alleviating the paraquat-incurred acute kidney injury, observed by the improvement, and reduced serum and urine markers that indicate a kidney injury.
Betanin also decreased oxidative stress elicited by paraquat by increasing the expression of antioxidant enzymes produced by the host accompanied by inhibiting the levels of free radicals.
These results suggested that betanin protects the tested rats against kidney damage due to oxidative stress in the induction of chronic inflammation.
In streptozotocin (STZ) induced diabetes (DN) in rats, researchers examined the betanin anti-fibrotic mechanisms in rat kidneys.
Betanin at a dose of 25, 50 and 100mg/kg/day and lisinopril (5mg/kg/day, reference compound) orally administered for 8 weeks after the induction of DN, not only significantly inhibited proteinuria, blood glucose, serum creatinine and blood urea nitrogen (BUN) levels involved in kidney injury, but also restored antioxidant enzyme activities in kidney tissue.
Additionally, betanin treatment also protects kidney integrity by reducing the glomerular surface area, glomerulosclerosis, and tubulointerstitial fibrosis.
In other words, betanin demonstrated the kidney protective activity against streptozotocin (STZ) induced diabetes (DN) in rats through regulation of transforming growth factor beta (TGF-β) in facilitating anti-oxidative and anti-inflammatory activity.
Taken altogether, betanin may be considered a supplement for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat by Tan D1, Wang Y2, Bai B1, Yang X2, Han J. (PubMed)
(2) Betanin, isolated from fruits of Opuntia elatior Mill attenuates renal fibrosis in diabetic rats through regulating oxidative stress and TGF-β pathway by Sutariya B1, Saraf M2.(PubMed)
(3) Oxidative Stress, From Liver Pathophysiology, 2017. (Science Direct)
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