Kyle J. Norton
The bioactive compound Sinigrin may be used as antibiotic for the treatment of fungal infection, studies suggested.
Antibiotics are conventional medicines used for the treatment of microbial infections except for viruses.
Fungi are a kind of living organism, including molds, molds, and mushrooms.
Most cases of fungal infections start in the lungs or on the skin. People with a weakened immune system or long-term use of antibiotics and immune-suppressive medicine are prone to getting a fungal infection.
Histoplasmosis, which is the most common fungal infection in the US, is caused by the dimorphic fungus Histoplasma capsulatum var. capsulatum.
However, invasive candidiasis is a common infection, approximately 46,000 cases of invasive candidiasis are diagnosed in the US each year.
Believe it or not, there are millions of different fungal species on the Earth, but only about 300 of those make people sick.
Most cases of fungal infection are treated with antibiotics topically or orally.
The untreated fungal infection may cause the spread of fungi to the bloodstream, leading to serious complications including death depending on type of fungal infection.
Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Researchers with an aim to find a natural ingredient used by traditional medicine for the treatment of fungal infection investigated the effect of sinigrin in the form of isothiocyanates (ITCs)against Alternaria brassicicola.
Exposure of the fungus to ICTs led to apoptosis through the decreased oxygen consumption rate, intracellular accumulation of reactive oxygen species (ROS), and mitochondrial membrane depolarization.
The effects of fungal-induced infection on the activation of the mitogen-activated protein (MAP) kinase signaling pathway involved in directing cellular responses to a diverse array of stimuli, were inhibited by the presence of ICTs.
The injection of ICTs also induced the expression of oxygen-reactive species in killing the fungi through cytotoxicity.
However, ICT-derived ROS was also countered by the expression of different oxidative-response genes stimulated by the Alternaria brassicicola.
The findings strongly suggested that ITCs exert their toxicity on fungal cells.
Taken together, sinigrin in the form of isothiocyanates (ITCs) may be considered a supplement for the prevention and treatment of fungal infection, pending the confirmation of a larger sample size and multicenter human study.
Intake of sinigrin as a supplement should be taken with extreme care to prevent overdose-induced liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Glucosinolate-derived isothiocyanates impact mitochondrial function in fungal cells and elicit an oxidative stress response necessary for growth recovery by Benoit Calmes,1,† Guillaume N’Guyen,1,† Jérome Dumur,1 Carlos A. Brisach,1Claire Campion,1 Béatrice Iacomi,2 Sandrine Pigné,2 Eva Dias,1 David Macherel,1Thomas Guillemette,1 and Philippe Simoneau. (PMC)
Monday, 4 September 2023
#Cucurbitacin B Found in #Cuccumber Inhibits Non Small Lung Cancer Cells through G2/M Cell-Cycle Arrest and Mitochondrial Apoptosis
Kyle J. Norton
Lung cancer is a medical condition that causes abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells.
Non-small lung cancer is the most common type of lung cancer that accounts for 80% to 85% of all cases of lung cancers, usually grows and spreads methodically and predictably.
The most common types of lung cancers include
* Squamous-cell carcinoma often found in an outer area of the lung
* Large-cell carcinoma found in the center of the lung by an air tube
* Adenocarcinoma is found in any part of the lung.
According to the statistics provided by the American Cancer Society, lung cancer is a leading cause of death among both men and women. Most people diagnosed with lung cancer are 65 or older, compared to a very small number of people diagnosed who are younger than 45.
The most common prevalent factors of non-small cell lung cancer include
1. Smoking
Smoking is a major cause of lung cancer by enhancing oxidation stress by combining the inhaled air with cancer-causing chemical substances (carcinogens) in the cigarette.
Normally, our body can withstand and repair this damage, but prolonged exposure your lung to these dangerous carcinogens can result in lung cancer development.
2. Second-hand smoke
Prolonged exposure to second-hand smoke can also increase the risk of lung cancer.
3. Exposure to certain chemicals
There is an increased risk of lung cancer for people who inhale or are exposed to certain industrial chemicals such as radon gas, arsenic, chromium, nickel, etc. in the workplace.
4. Family history
The risk of lung cancer increases if one of the members of your direct family has lung cancer.
5. Lung disease
The risk of ling can caner increase if you have or previously had certain types of lung disease
6. Excessive drinking
According to the study by Freudenheim et al., R. Curtis Ellison MD suggested that alcohol intake of more than 2 drinks per day is associated with a small increased risk of lung cancer. This study, like others, suggests a weak, positive association with consuming larger amounts of alcohol (>2 drinks a day) and lung cancer risk.
Out of many risk factors, some researchers aging may be one of the major condition as most patients with lung cancer was diagnosed at the age of 65 and over.
Dr. Federico Venuta, the lead researcher wrote, "The respiratory system undergoes a number of structural, physiological, and immunological changes with age. For this reason, at this stage of our life, it is not always easy to differentiate disease from a normal state".
, "From the epidemiological point of view, early-stage lung cancer is observed more frequently in elderly patients; in fact, stage I disease increases from 79% in patients younger than 65 years to 87% in those above 75 years (25). Also, resectability obviously increases with age (1,26): from 15.3% in those younger than 54 years to 25% above 75 years".
The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural and potential compound for the treatment of non-small lung cancer (NSCLC) with no side effects, researchers investigated Cucurbitacin B (CuB), a natural compound isolated from cucumber and other vegetables anti-NSCLC in vitro.
Four NSCLC cells (H1299, A549, HCC-827, and H661) in vitro and the highly aggressive H1299 xenograft in vivo were included in the study.
According to the tested assays, CuB significantly induced G2/M cell-cycle arrest and mitochondrial apoptosis.
Injection by the thiol antioxidant N-acetylcysteine (NAC) in the experiment showed to attenuate all cellular effects of CuB completely.
Interestingly, pretreatment with glutathione synthesis inhibitor glutathione-sulfoxide (BSO), significantly exacerbated CuB's cytotoxic effects against the tested cancer cells in both vitro and vivo.
Further analysis of the anti-NSCLC efficacy of CuB, researchers found that CuB induces cell death via rapidly and significantly decrease the levels of protein thiols and GSH/GSSG ratio by disrupting cellular redox balance induced cytotoxicity.
Dr. Kausar H, the lead scientist said, "CuB interacts with and modulates cellular thiols to mediate its anti-cancer effects. Collectively, our data shed new light on the working mechanisms of CuB and demonstrate its therapeutic potential against NSCLC".
Furthermore, CuB also exerted anti-NSCLC in vitro and vivo CuB by exhibiting a strong anti-migratory and anti-invasive ability against metastatic NSCLC at nanomolar concentrations.
In other words, CuB showed significant tumor angiogenesis-inhibitory effects by the inhibition of migratory, invasive, and tube-forming capacities of human umbilical vein endothelial cells.
Moreover, in experimental EMT model CuB also suppressed the overexpression of protein associated with the production of proinflammatory cytokines in the initiation of cellular change and Wnt/β-catenin signaling axis in stimulating the production of formation of new blood vessels to facilitate cancer proliferation.
Taken altogether, cucumber processed with a high amount of CuB may be considered supplements for the prevention and treatment of non-small cell lung cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets by Kausar H1, Munagala R, Bansal SS, Aqil F, Vadhanam MV, Gupta RC. (PubMed)
(2) Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis by Shukla S1, Sinha S1, Khan S1, Kumar S2, Singh K3, Mitra K3, Maurya R2, Meeran SM. (PubMed)
(3) Lung cancer in elderly patients by Federico Venuta,
Daniele Diso, Ilaria Onorati, Marco Anile, Sara Mantovani, and Erino A. Rendina. (PMC)
Lung cancer is a medical condition that causes abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells.
Non-small lung cancer is the most common type of lung cancer that accounts for 80% to 85% of all cases of lung cancers, usually grows and spreads methodically and predictably.
The most common types of lung cancers include
* Squamous-cell carcinoma often found in an outer area of the lung
* Large-cell carcinoma found in the center of the lung by an air tube
* Adenocarcinoma is found in any part of the lung.
According to the statistics provided by the American Cancer Society, lung cancer is a leading cause of death among both men and women. Most people diagnosed with lung cancer are 65 or older, compared to a very small number of people diagnosed who are younger than 45.
The most common prevalent factors of non-small cell lung cancer include
1. Smoking
Smoking is a major cause of lung cancer by enhancing oxidation stress by combining the inhaled air with cancer-causing chemical substances (carcinogens) in the cigarette.
Normally, our body can withstand and repair this damage, but prolonged exposure your lung to these dangerous carcinogens can result in lung cancer development.
2. Second-hand smoke
Prolonged exposure to second-hand smoke can also increase the risk of lung cancer.
3. Exposure to certain chemicals
There is an increased risk of lung cancer for people who inhale or are exposed to certain industrial chemicals such as radon gas, arsenic, chromium, nickel, etc. in the workplace.
4. Family history
The risk of lung cancer increases if one of the members of your direct family has lung cancer.
5. Lung disease
The risk of ling can caner increase if you have or previously had certain types of lung disease
6. Excessive drinking
According to the study by Freudenheim et al., R. Curtis Ellison MD suggested that alcohol intake of more than 2 drinks per day is associated with a small increased risk of lung cancer. This study, like others, suggests a weak, positive association with consuming larger amounts of alcohol (>2 drinks a day) and lung cancer risk.
Out of many risk factors, some researchers aging may be one of the major condition as most patients with lung cancer was diagnosed at the age of 65 and over.
Dr. Federico Venuta, the lead researcher wrote, "The respiratory system undergoes a number of structural, physiological, and immunological changes with age. For this reason, at this stage of our life, it is not always easy to differentiate disease from a normal state".
, "From the epidemiological point of view, early-stage lung cancer is observed more frequently in elderly patients; in fact, stage I disease increases from 79% in patients younger than 65 years to 87% in those above 75 years (25). Also, resectability obviously increases with age (1,26): from 15.3% in those younger than 54 years to 25% above 75 years".
The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural and potential compound for the treatment of non-small lung cancer (NSCLC) with no side effects, researchers investigated Cucurbitacin B (CuB), a natural compound isolated from cucumber and other vegetables anti-NSCLC in vitro.
Four NSCLC cells (H1299, A549, HCC-827, and H661) in vitro and the highly aggressive H1299 xenograft in vivo were included in the study.
According to the tested assays, CuB significantly induced G2/M cell-cycle arrest and mitochondrial apoptosis.
Injection by the thiol antioxidant N-acetylcysteine (NAC) in the experiment showed to attenuate all cellular effects of CuB completely.
Interestingly, pretreatment with glutathione synthesis inhibitor glutathione-sulfoxide (BSO), significantly exacerbated CuB's cytotoxic effects against the tested cancer cells in both vitro and vivo.
Further analysis of the anti-NSCLC efficacy of CuB, researchers found that CuB induces cell death via rapidly and significantly decrease the levels of protein thiols and GSH/GSSG ratio by disrupting cellular redox balance induced cytotoxicity.
Dr. Kausar H, the lead scientist said, "CuB interacts with and modulates cellular thiols to mediate its anti-cancer effects. Collectively, our data shed new light on the working mechanisms of CuB and demonstrate its therapeutic potential against NSCLC".
Furthermore, CuB also exerted anti-NSCLC in vitro and vivo CuB by exhibiting a strong anti-migratory and anti-invasive ability against metastatic NSCLC at nanomolar concentrations.
In other words, CuB showed significant tumor angiogenesis-inhibitory effects by the inhibition of migratory, invasive, and tube-forming capacities of human umbilical vein endothelial cells.
Moreover, in experimental EMT model CuB also suppressed the overexpression of protein associated with the production of proinflammatory cytokines in the initiation of cellular change and Wnt/β-catenin signaling axis in stimulating the production of formation of new blood vessels to facilitate cancer proliferation.
Taken altogether, cucumber processed with a high amount of CuB may be considered supplements for the prevention and treatment of non-small cell lung cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets by Kausar H1, Munagala R, Bansal SS, Aqil F, Vadhanam MV, Gupta RC. (PubMed)
(2) Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis by Shukla S1, Sinha S1, Khan S1, Kumar S2, Singh K3, Mitra K3, Maurya R2, Meeran SM. (PubMed)
(3) Lung cancer in elderly patients by Federico Venuta,
Daniele Diso, Ilaria Onorati, Marco Anile, Sara Mantovani, and Erino A. Rendina. (PMC)
#Fennel #Extract Processes Cyto-Protection and Antitumor Activity By Inhibiting the Onset of Oxidativestress, Researchers Reveal
Kyle J. Norton
Fennel may have a potential and positive effect that induces cytoprotection and antitumor activity against cancer expression, scientists suggested.
The results of fennel efficacy were reported by several respectable institutes including the National Cancer Institute and the National Institute of Health.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the study to evaluate the efficacy of fennel seed methanolic extract (FSME) for its antioxidant, cytotoxic, and antitumor activities and for its capacity to serve as a nontoxic radioprotector in Swiss albino mice through injection of FSME, 100 mg/kg intraperitoneally into mice bearing EAC before exposed to three 2-Gy doses of gamma irradiation, researchers found at after 30 days, the application exerted a strong effect at the C50 (mean standard deviation 50% inhibitory concentrations) at a dose of 50 μg/mL for the MCF7 breast cancer cell line and 48 μg/mL for the Hepg-2 liver cancer cell line.
The treatment group also displayed a decreased level of MDA and improved natural antioxidants produced by the tissues of the host compared to the elevation of MDA and significantly reduced levels of catalase and GSH contents.
These results suggested that fennel seed methanolic extract (FSME) inhibited the overproduction of ROS caused by ingestion of doses of gamma irradiation through its antioxidant and enhanced antioxidant production of the mice tissue via the ratio of ROS and Antioxidants.
In other words, the application of the fennel extract may have the potential in
* Reduced oxidative stress and protected mouse cells from damage caused by reactive oxygen species.
* Improved natural antioxidants and the oxidative stability of fatty foods during storage.
* Exhibited an antitumor effect by modulating lipid peroxidation and augmenting the antioxidant defense system in EAC-bearing mice with or without exposure to radiation.
Further illustration of the effect of herbal medicine in treatment of cancers and examine the cytoprotective effects, researchers at the National Institute of Health conducted a comparison of five herbal supplements, designated FB, FM, PP, HF, and FBL101, which contain different combinations of various natural herbs such as licorice, black cohosh, Dong Quai, false unicorn and vitex berry root against mice bearing CWR22R and PC3 prostate cancer xenografts.
According to the results of the experiment,
* All herbal medicine, FB, FM, PP, HF, and FBL101 inhibited PC3 tumor growth by 53%, 75%, 80%, 81%, and 87%, respectively.
* In CWR22R tumors, applications of supplements exerted a similar effect in suppressing the cancer cells.
* All applications did not show inhibitory activity against levels of testosterone compared to untreated mice. However, supplements PP and FBL101 exerted significantly reduced VEGF levels, a potent angiogenic factor with function in stimulated production of new blood vessels to ensure cell proliferation, in PC3 and CWR22R tumors.
* Intratumoral microvessel density was decreased in PC3 tumors treated with all five supplements but only in CWR22R tumors treated with HF.
Dr. Ng SS, the lead author said, "Herbal supplements containing the aforementioned extracts inhibit the growth of prostate tumor xenografts, possibly in part by antiangiogenic mechanisms".
The above differentiation was supported by Quaid-i-Azam University in the analysis of the antibacterial potential of some medicinal plants against multi-drug resistant (MDR) pathogens and anticancer effect against the MCF-7 cell line.
According to the results of the report, the application of Ethanol extract of Foeniculum vulgare exhibited significant inhibition of cancer cell proliferation and induction of cancer cell apoptosis and reduction of growth of Klebsiella pneumonia, Serratia marcescens, and Methicillin-resistant S. aureus. Pseudomonas aeruginosa
Taken together, fennel and its extracts may be used as a functional food in the exertion of cytoprotection and antitumor activity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Antioxidant and anticarcinogenic effects of methanolic extract and volatile oil of fennel seeds (Foeniculum vulgare) by Mohamad RH1, El-Bastawesy AM, Abdel-Monem MG, Noor AM, Al-Mehdar HA, Sharawy SM, El-Merzabani MM. (PubMed)
(2) Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice by Ng SS1, Figg WD. (PubMed)
(3) Study of anticancer and antibacterial activities of Foeniculum vulgare, Justicia adhatoda, and Urtica dioica as natural curatives by Batool R1, Salahuddin H1, Mahmood T1, Ismail M2. (PubMed)
#Phytochemical #Betanin Inhibits Diseases Associated with Oxidative Stress, Researchers Say
Kyle J. Norton
Oxidative stress is a condition caused by an imbalance of the ratio of free radicals and antioxidants in the body.
In other words, oxidative stress is either caused by overexpression of free radicals or depletion of antioxidant enzymes in the body.
Some researchers suggested that oxidative stress may also arise due to the chain reaction of free radicals in which free radicals donate or intercept an electron from other stable molecules.
Long-term oxidative stress present in the body can cause protein and lipid damage and alternation of cell DNA, leading to the onset of chronic diseases, including cardiovascular disease, diabetes, and cancer.
More precisely, exogenous factors, such as cigarette smoke, and endogenous factors, such as the oxidative burst from activated macrophages are some of the factors involved in the risk of oxidative stress.
The Liver Pathophysiology, 2017 in the explanation of the cause of oxidative stress, wrote, " (1) the presence of xenobiotics, (2) the activation of the immune system in response to invading microorganisms (inflammation), and (3) radiation, which makes oxidative stress a common denominator of toxicity or stress".
In other words, oxidative stress may be preventable by following a diet rich in antioxidants such as a diet with higher fruit and vegetable consumption accompanied by moderate exercise and reduced intake of saturated and trans fat and processed foods.
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the prevention of diseases associated with oxidative stress, researchers examined the effects of natural pigment betanin on oxidative stress in the kidney of paraquat-treated rats.
Paraquat injected intraperitoneally induced renal damage rats were randomly divided into four groups: a control group, a paraquat group, and two paraquat groups that were treated with betanin at 25 and 100 mg/kg/d three days before and two days after paraquat administration.
Betanin-treated rats showed strong activity in alleviating the paraquat-incurred acute kidney injury, observed by the improvement, and reduced serum and urine markers that indicate a kidney injury.
Betanin also decreased oxidative stress elicited by paraquat by increasing the expression of antioxidant enzymes produced by the host accompanied by inhibiting the levels of free radicals.
These results suggested that betanin protects the tested rats against kidney damage due to oxidative stress in the induction of chronic inflammation.
In streptozotocin (STZ) induced diabetes (DN) in rats, researchers examined the betanin anti-fibrotic mechanisms in rat kidneys.
Betanin at a dose of 25, 50 and 100mg/kg/day and lisinopril (5mg/kg/day, reference compound) orally administered for 8 weeks after the induction of DN, not only significantly inhibited proteinuria, blood glucose, serum creatinine and blood urea nitrogen (BUN) levels involved in kidney injury, but also restored antioxidant enzyme activities in kidney tissue.
Additionally, betanin treatment also protects kidney integrity by reducing the glomerular surface area, glomerulosclerosis, and tubulointerstitial fibrosis.
In other words, betanin demonstrated the kidney protective activity against streptozotocin (STZ) induced diabetes (DN) in rats through regulation of transforming growth factor beta (TGF-β) in facilitating anti-oxidative and anti-inflammatory activity.
Taken altogether, betanin may be considered a supplement for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat by Tan D1, Wang Y2, Bai B1, Yang X2, Han J. (PubMed)
(2) Betanin, isolated from fruits of Opuntia elatior Mill attenuates renal fibrosis in diabetic rats through regulating oxidative stress and TGF-β pathway by Sutariya B1, Saraf M2.(PubMed)
(3) Oxidative Stress, From Liver Pathophysiology, 2017. (Science Direct)
Oxidative stress is a condition caused by an imbalance of the ratio of free radicals and antioxidants in the body.
In other words, oxidative stress is either caused by overexpression of free radicals or depletion of antioxidant enzymes in the body.
Some researchers suggested that oxidative stress may also arise due to the chain reaction of free radicals in which free radicals donate or intercept an electron from other stable molecules.
Long-term oxidative stress present in the body can cause protein and lipid damage and alternation of cell DNA, leading to the onset of chronic diseases, including cardiovascular disease, diabetes, and cancer.
More precisely, exogenous factors, such as cigarette smoke, and endogenous factors, such as the oxidative burst from activated macrophages are some of the factors involved in the risk of oxidative stress.
The Liver Pathophysiology, 2017 in the explanation of the cause of oxidative stress, wrote, " (1) the presence of xenobiotics, (2) the activation of the immune system in response to invading microorganisms (inflammation), and (3) radiation, which makes oxidative stress a common denominator of toxicity or stress".
In other words, oxidative stress may be preventable by following a diet rich in antioxidants such as a diet with higher fruit and vegetable consumption accompanied by moderate exercise and reduced intake of saturated and trans fat and processed foods.
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the prevention of diseases associated with oxidative stress, researchers examined the effects of natural pigment betanin on oxidative stress in the kidney of paraquat-treated rats.
Paraquat injected intraperitoneally induced renal damage rats were randomly divided into four groups: a control group, a paraquat group, and two paraquat groups that were treated with betanin at 25 and 100 mg/kg/d three days before and two days after paraquat administration.
Betanin-treated rats showed strong activity in alleviating the paraquat-incurred acute kidney injury, observed by the improvement, and reduced serum and urine markers that indicate a kidney injury.
Betanin also decreased oxidative stress elicited by paraquat by increasing the expression of antioxidant enzymes produced by the host accompanied by inhibiting the levels of free radicals.
These results suggested that betanin protects the tested rats against kidney damage due to oxidative stress in the induction of chronic inflammation.
In streptozotocin (STZ) induced diabetes (DN) in rats, researchers examined the betanin anti-fibrotic mechanisms in rat kidneys.
Betanin at a dose of 25, 50 and 100mg/kg/day and lisinopril (5mg/kg/day, reference compound) orally administered for 8 weeks after the induction of DN, not only significantly inhibited proteinuria, blood glucose, serum creatinine and blood urea nitrogen (BUN) levels involved in kidney injury, but also restored antioxidant enzyme activities in kidney tissue.
Additionally, betanin treatment also protects kidney integrity by reducing the glomerular surface area, glomerulosclerosis, and tubulointerstitial fibrosis.
In other words, betanin demonstrated the kidney protective activity against streptozotocin (STZ) induced diabetes (DN) in rats through regulation of transforming growth factor beta (TGF-β) in facilitating anti-oxidative and anti-inflammatory activity.
Taken altogether, betanin may be considered a supplement for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of a larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat by Tan D1, Wang Y2, Bai B1, Yang X2, Han J. (PubMed)
(2) Betanin, isolated from fruits of Opuntia elatior Mill attenuates renal fibrosis in diabetic rats through regulating oxidative stress and TGF-β pathway by Sutariya B1, Saraf M2.(PubMed)
(3) Oxidative Stress, From Liver Pathophysiology, 2017. (Science Direct)
#Phytochemical Alliin Exerts Antioxidant Activity Against the Onset of Hyperglycemia and #DiabeticComplications, Researchers Say
Kyle J. Norton
Diabetes is a medical condition characterized by the failure of the body to utilize the insulin in converting glucose to energy, leading to high levels of glucose in the bloodstream.
Most cases of diabetes are associated with either beta cells of the pancreas died-off or insulin receptor site clogged-up by fat and cholesterol.
Diabetic complications in most cases are caused by long-term unmanaged hyperglycemia, a hallmark of diabetes.
Hyperglycemia occurs in diabetics due to uncontrolled diet, skip diabetes medication and improper use of insulin injection.
The most common complication of diabetes is associated with the damage of tiny blood vessels that nourish the related organ and tissues, leading to the risk for developing microvascular and macrovascular complications. includes
* Cardiovascular disease
* Nerve damage
* Kidney damage
* Eye damage
* Foot damage
And skin problems
Dr. Waqas Sami, in the evaluation of the effect of diet and type 2 diabetes wrote, "Dietary habits and sedentary lifestyle are the major factors for the rapidly rising incidence of DM among developing countries".
And, "In type 2 diabetics, recently, elevated HbA1c level has also been considered as one of the leading risk factors for developing microvascular and macrovascular complications. Improvement in the elevated HbA1c level can be achieved through diet management; thus, the patients could be prevented from developing diabetes complications".
In other words, by following a healthy diet to normalize the levels of HbA1c level, accompanied by moderate exercise, the risk of diabetic complications can be manageable.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
On finding a potential compound for the prevention of diabetic complications, researchers examined the effect of alliin, the most abundant sulfur compound in garlic antidiabetic complications against glycation.
Where advanced glycation is considered one of the major pathways associated with the development and progression of a number of diabetic complications including nephropathy, retinopathy, and neuropathy.
Based on the results, alliin exerted a significant effect on glucose and methylglyoxal (MG)-induced by glycation of superoxide dismutase (SOD), which leads to decreased antioxidant enzyme activity, fragmentation/cross-linking in fragment ion association with impaired cross-link, and reduced cross-reactivity with anti-SOD antibodies.
Moreover, the expression of glycation of SOD also leads to the formation of AGEs and fibrils.
In other words, alliin offered protection against elevated levels of glucose or MG-induced glycation of SOD.
Additionally, alliin efficacy against the onset of hyperglycemia was comparable with that of quercetin which is reported to be a potent natural inhibitor of glycation.
Based on the findings, researchers wrote, "Alliin has a good antiglycation effect and hence is expected to have therapeutic potential in the prevention of glycation-mediated diabetic complications".
Taken together, alliin may be considered a supplement for the prevention of glycation-mediated diabetic complications, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Characterization of antioxidant activity of sulfur compounds in black garlic by Wang WD1, Sun YE1, Chen HW. (PubMed)
(2) Inhibitory effect of alliin from Allium sativum on the glycation of superoxide dismutase by Anwar S1, Younus H. (PubMed)
(3) Effect of diet on type 2 diabetes mellitus: A review by Waqas Sami,1,2 Tahir Ansari,3 Nadeem Shafique Butt,4 and Mohd Rashid Ab Hamid. (PMC)
Diabetes is a medical condition characterized by the failure of the body to utilize the insulin in converting glucose to energy, leading to high levels of glucose in the bloodstream.
Most cases of diabetes are associated with either beta cells of the pancreas died-off or insulin receptor site clogged-up by fat and cholesterol.
Diabetic complications in most cases are caused by long-term unmanaged hyperglycemia, a hallmark of diabetes.
Hyperglycemia occurs in diabetics due to uncontrolled diet, skip diabetes medication and improper use of insulin injection.
The most common complication of diabetes is associated with the damage of tiny blood vessels that nourish the related organ and tissues, leading to the risk for developing microvascular and macrovascular complications. includes
* Cardiovascular disease
* Nerve damage
* Kidney damage
* Eye damage
* Foot damage
And skin problems
Dr. Waqas Sami, in the evaluation of the effect of diet and type 2 diabetes wrote, "Dietary habits and sedentary lifestyle are the major factors for the rapidly rising incidence of DM among developing countries".
And, "In type 2 diabetics, recently, elevated HbA1c level has also been considered as one of the leading risk factors for developing microvascular and macrovascular complications. Improvement in the elevated HbA1c level can be achieved through diet management; thus, the patients could be prevented from developing diabetes complications".
In other words, by following a healthy diet to normalize the levels of HbA1c level, accompanied by moderate exercise, the risk of diabetic complications can be manageable.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
On finding a potential compound for the prevention of diabetic complications, researchers examined the effect of alliin, the most abundant sulfur compound in garlic antidiabetic complications against glycation.
Where advanced glycation is considered one of the major pathways associated with the development and progression of a number of diabetic complications including nephropathy, retinopathy, and neuropathy.
Based on the results, alliin exerted a significant effect on glucose and methylglyoxal (MG)-induced by glycation of superoxide dismutase (SOD), which leads to decreased antioxidant enzyme activity, fragmentation/cross-linking in fragment ion association with impaired cross-link, and reduced cross-reactivity with anti-SOD antibodies.
Moreover, the expression of glycation of SOD also leads to the formation of AGEs and fibrils.
In other words, alliin offered protection against elevated levels of glucose or MG-induced glycation of SOD.
Additionally, alliin efficacy against the onset of hyperglycemia was comparable with that of quercetin which is reported to be a potent natural inhibitor of glycation.
Based on the findings, researchers wrote, "Alliin has a good antiglycation effect and hence is expected to have therapeutic potential in the prevention of glycation-mediated diabetic complications".
Taken together, alliin may be considered a supplement for the prevention of glycation-mediated diabetic complications, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Characterization of antioxidant activity of sulfur compounds in black garlic by Wang WD1, Sun YE1, Chen HW. (PubMed)
(2) Inhibitory effect of alliin from Allium sativum on the glycation of superoxide dismutase by Anwar S1, Younus H. (PubMed)
(3) Effect of diet on type 2 diabetes mellitus: A review by Waqas Sami,1,2 Tahir Ansari,3 Nadeem Shafique Butt,4 and Mohd Rashid Ab Hamid. (PMC)
#Phytochemical Betacyanins Exhibit Cytotoxic Effects on #ProstateCancer and #BreastCancer, Researchers Reveal
Kyle J. Norton
The cytotoxic effect is the process of killing cells through toxic substances, particularly in cancer cells.
Chemotherapy is a treatment that uses drugs to treat any disease, including cancer.
Chemo drug also has been used to shrink the tumor before surgery or combined radiotherapy to remove, kill, or damage cancer cells in a certain area,
Chemo travels along the bloodstream to kill cancer cells throughout the whole body.
There are over 100 different types of chemodrugs, including
* Docetaxel (Taxotere), is a type of chemo drug used for the treatment of a chemotherapy drug. It is used to treat many types of cancer including breast, prostate, stomach, head and neck, and non-small cell lung cancer (NSCLC).
* Eribulin (Halaven) is used mostly for the treatment of breast cancer by interfering with cancer cell division and growth.
* Ixabepilone (Ixempra) is used in patients with locally advanced or metastatic breast cancer.
* Paclitaxel (Taxol) has been used for the treatment of used to treat a number of types of cancers, including ovarian cancer, breast cancer, lung cancer, Kaposi sarcoma, cervical cancer, and pancreatic cancer.
* Vinblastine is most commonly used for the treatment of Hodgkin's lymphoma, non-small cell lung cancer, bladder cancer, brain cancer, melanoma, and testicular cancer.
Conventionally, chemo drugs have been found to induce serious side effects, including fatigue due to the loss of healthy cells, hair loss associated with the damage of hair follicles, easy bruising, and bleeding, infection due to the weakened immune system, anemia is caused by the loss of red blood cells, digestive symptoms such as nausea and vomiting, appetite changes, and constipation.
Some of the symptoms may be going away as soon as the treatment stops. However, some symptoms may take months or years after the treatment stops before disappearing
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In finding a natural compound for the treatment of cancer, researchers examined the extract of red beetroot (Beta vulgaris L.), the FDA-approved red food color E162, cytotoxic effect.
Compared to the chemo drug doxorubicin (adriamycin), betanin, the major betacyanin constituent has been shown to exhibit a dose-dependent cytotoxic effect on human prostate cancer cells (PC-3) and in the well-established estrogen receptor-positive human breast cancer cells (MCF-7), comparable to those of doxorubicin.
In time analysis, although the cytotoxicity of the beetroot extract was significantly lower compared to doxorubicin which completely inhibits the growth of the PC-3 cells in three days, the extract continued to decrease the growth rate of the PC-3 cells (3.7% in 3 days vs. 12.5% in 7 days) at the concentration of 29 µg/ml.
Furthermore, in the normal human skin FC and liver HC cell lines, the extract showed a significantly lower cytotoxic effect compared to doxorubicin (8.6% vs. 100%, respectively, at 29 µg/ml concentration of each, three-day test period).
In chemical differentiation, the efficacy of beetroot extract was attributed to the chemical compound betanin, the major betacyanin constituent in exerting the cytotoxicity.
Based on the finding, researchers said, "Further studies are needed to evaluate the chemopreventive potentials of the beetroot extract when used alone or in combination with doxorubicin to mitigate the toxic side-effects of the latter".
Taken altogether, betacyanins processed as the major bioactive ingredient betanin may be considered a remedy for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer-cell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)
The cytotoxic effect is the process of killing cells through toxic substances, particularly in cancer cells.
Chemotherapy is a treatment that uses drugs to treat any disease, including cancer.
Chemo drug also has been used to shrink the tumor before surgery or combined radiotherapy to remove, kill, or damage cancer cells in a certain area,
Chemo travels along the bloodstream to kill cancer cells throughout the whole body.
There are over 100 different types of chemodrugs, including
* Docetaxel (Taxotere), is a type of chemo drug used for the treatment of a chemotherapy drug. It is used to treat many types of cancer including breast, prostate, stomach, head and neck, and non-small cell lung cancer (NSCLC).
* Eribulin (Halaven) is used mostly for the treatment of breast cancer by interfering with cancer cell division and growth.
* Ixabepilone (Ixempra) is used in patients with locally advanced or metastatic breast cancer.
* Paclitaxel (Taxol) has been used for the treatment of used to treat a number of types of cancers, including ovarian cancer, breast cancer, lung cancer, Kaposi sarcoma, cervical cancer, and pancreatic cancer.
* Vinblastine is most commonly used for the treatment of Hodgkin's lymphoma, non-small cell lung cancer, bladder cancer, brain cancer, melanoma, and testicular cancer.
Conventionally, chemo drugs have been found to induce serious side effects, including fatigue due to the loss of healthy cells, hair loss associated with the damage of hair follicles, easy bruising, and bleeding, infection due to the weakened immune system, anemia is caused by the loss of red blood cells, digestive symptoms such as nausea and vomiting, appetite changes, and constipation.
Some of the symptoms may be going away as soon as the treatment stops. However, some symptoms may take months or years after the treatment stops before disappearing
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In finding a natural compound for the treatment of cancer, researchers examined the extract of red beetroot (Beta vulgaris L.), the FDA-approved red food color E162, cytotoxic effect.
Compared to the chemo drug doxorubicin (adriamycin), betanin, the major betacyanin constituent has been shown to exhibit a dose-dependent cytotoxic effect on human prostate cancer cells (PC-3) and in the well-established estrogen receptor-positive human breast cancer cells (MCF-7), comparable to those of doxorubicin.
In time analysis, although the cytotoxicity of the beetroot extract was significantly lower compared to doxorubicin which completely inhibits the growth of the PC-3 cells in three days, the extract continued to decrease the growth rate of the PC-3 cells (3.7% in 3 days vs. 12.5% in 7 days) at the concentration of 29 µg/ml.
Furthermore, in the normal human skin FC and liver HC cell lines, the extract showed a significantly lower cytotoxic effect compared to doxorubicin (8.6% vs. 100%, respectively, at 29 µg/ml concentration of each, three-day test period).
In chemical differentiation, the efficacy of beetroot extract was attributed to the chemical compound betanin, the major betacyanin constituent in exerting the cytotoxicity.
Based on the finding, researchers said, "Further studies are needed to evaluate the chemopreventive potentials of the beetroot extract when used alone or in combination with doxorubicin to mitigate the toxic side-effects of the latter".
Taken altogether, betacyanins processed as the major bioactive ingredient betanin may be considered a remedy for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer-cell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)
#BrusselsSprouts Inhibit Overexpression of Oxidative Stress Accumulation, Inflammation, Renal Damage, and Proteinuria, Researchers Say
Kyle J. Norton
Hypertension is a condition of abnormally high blood pressure in the bloodstream. Hypertension a member of the cluster conditions of metabolic syndrome associated with an increased risk of cardiovascular disease and diabetes.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
According to the statistics provided by the American Heart Association, approximately, 103 million U.S. adults have high blood pressure, or 1 in 2 adults in the US have the syndrome.
The kidneys are two bean-shaped organs located just below the rib cage, one on each side of your spine.
The kidneys formed a second detoxed organ in the body after the liver not only plays an essential role in regulating electrolytes, and blood pressure, maintains acid-base balance, and produces hormone calcitriol, renin, and erythropoietin,... but also filters blood that passes into the tubules. In the Urinary system, kidneys reabsorb some necessary substances back into the blood, while waste, such as urea and ammonium is deposited into the pelvis and then into the ureter to the bladder for secretion.
Kidney disease is a condition that reduces the function of the kidney acutely or gradually.
Kidney damage is a condition that causes the reduced function of the kidney. Over time untreated kidney damage can induce the formation of scars. Over-expression of kidney scars can lead to kidney disease and kidney failure in severe cases.
According to the statistics, approximately 14 percent of the US population suffers some form of chronic kidney disease (CKD), including 661,000 cases of kidney failure.
Believe it or not, almost half of the individuals with CKD also have diabetes and/or self-reported cardiovascular disease (CVD).
Blood in urine, protein in the urine, kidney stones, kidney infection, kidney pain, hepatitis C, and other forms of kidney diseases are signs of kidney disease that can lead to CKD.
With an aim to find a natural food for the prevention of stroke, researchers examined the effect of Brussels sprouts on the high-sodium/low-potassium-fed stroke-prone spontaneously hypertensive animal model.
Stroke-prone spontaneously hypertensive rat (SHRSP) received the Japanese diet for 4 weeks included in the study was divided into
* Nontreatment group.
* The SHRSP group received a Japanese diet and B. oleracea.
* A third group received a Japanese diet, B. oleracea, and PPARα inhibitor (GW6471).
* A group of SHRSPs fed with a regular diet served as control.
According to the tested analysis, compared to a regular diet, the group treated with a Japanese diet (high-sodium/low-potassium) showed induced increases in oxidative stress, inflammation, and proteinuria, along with glomerular and tubular damage.
The (AMPK/UCP2) pathway associated with the inhibition of ROS production and palmitate-induced apoptosis in endothelial cells was significantly suppressed by the Japanese diet.
However, Japanese diet-induced overexpression of oxidative stress accumulation, inflammation, renal damage, and proteinuria was totally prevented by the administration of Brussels sprouts.
Additionally, injection of Brussels sprouts also promoted the expression of antioxidant enzymes produced by the host observed by the increased level of a gene associated with drug toxicity without affecting the systolic blood pressure (SBP).
Taken together, Brussels sprouts may be considered supplements for the prevention of renal damage progression in hypertension, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP: role of AMPK/PPARα/UCP2 axis by Rubattu S1, Di Castro S, Cotugno M, Bianchi F, Mattioli R, Baima S, Stanzione R, Madonna M, Bozzao C, Marchitti S, Gelosa P, Sironi L, Pignieri A, Maldini M, Giusti AM, Nardini M, Morelli G, Costantino P, Volpe M. (PubMed)
Hypertension is a condition of abnormally high blood pressure in the bloodstream. Hypertension a member of the cluster conditions of metabolic syndrome associated with an increased risk of cardiovascular disease and diabetes.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
According to the statistics provided by the American Heart Association, approximately, 103 million U.S. adults have high blood pressure, or 1 in 2 adults in the US have the syndrome.
The kidneys are two bean-shaped organs located just below the rib cage, one on each side of your spine.
The kidneys formed a second detoxed organ in the body after the liver not only plays an essential role in regulating electrolytes, and blood pressure, maintains acid-base balance, and produces hormone calcitriol, renin, and erythropoietin,... but also filters blood that passes into the tubules. In the Urinary system, kidneys reabsorb some necessary substances back into the blood, while waste, such as urea and ammonium is deposited into the pelvis and then into the ureter to the bladder for secretion.
Kidney disease is a condition that reduces the function of the kidney acutely or gradually.
Kidney damage is a condition that causes the reduced function of the kidney. Over time untreated kidney damage can induce the formation of scars. Over-expression of kidney scars can lead to kidney disease and kidney failure in severe cases.
According to the statistics, approximately 14 percent of the US population suffers some form of chronic kidney disease (CKD), including 661,000 cases of kidney failure.
Believe it or not, almost half of the individuals with CKD also have diabetes and/or self-reported cardiovascular disease (CVD).
Blood in urine, protein in the urine, kidney stones, kidney infection, kidney pain, hepatitis C, and other forms of kidney diseases are signs of kidney disease that can lead to CKD.
With an aim to find a natural food for the prevention of stroke, researchers examined the effect of Brussels sprouts on the high-sodium/low-potassium-fed stroke-prone spontaneously hypertensive animal model.
Stroke-prone spontaneously hypertensive rat (SHRSP) received the Japanese diet for 4 weeks included in the study was divided into
* Nontreatment group.
* The SHRSP group received a Japanese diet and B. oleracea.
* A third group received a Japanese diet, B. oleracea, and PPARα inhibitor (GW6471).
* A group of SHRSPs fed with a regular diet served as control.
According to the tested analysis, compared to a regular diet, the group treated with a Japanese diet (high-sodium/low-potassium) showed induced increases in oxidative stress, inflammation, and proteinuria, along with glomerular and tubular damage.
The (AMPK/UCP2) pathway associated with the inhibition of ROS production and palmitate-induced apoptosis in endothelial cells was significantly suppressed by the Japanese diet.
However, Japanese diet-induced overexpression of oxidative stress accumulation, inflammation, renal damage, and proteinuria was totally prevented by the administration of Brussels sprouts.
Additionally, injection of Brussels sprouts also promoted the expression of antioxidant enzymes produced by the host observed by the increased level of a gene associated with drug toxicity without affecting the systolic blood pressure (SBP).
Taken together, Brussels sprouts may be considered supplements for the prevention of renal damage progression in hypertension, pending the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP: role of AMPK/PPARα/UCP2 axis by Rubattu S1, Di Castro S, Cotugno M, Bianchi F, Mattioli R, Baima S, Stanzione R, Madonna M, Bozzao C, Marchitti S, Gelosa P, Sironi L, Pignieri A, Maldini M, Giusti AM, Nardini M, Morelli G, Costantino P, Volpe M. (PubMed)
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