#Phytochemical Alliin Exerts Antioxidant Activity Against the Onset of Hyperglycemia and #DiabeticComplications, Researchers Say

Kyle J. Norton

Diabetes is a medical condition characterized by the failure of the body to utilize the insulin in converting glucose to energy, leading to high levels of glucose in the bloodstream.

Most cases of diabetes are associated with either beta cells of the pancreas died-off or insulin receptor site clogged-up by fat and cholesterol.

Diabetic complications in most cases are caused by long-term unmanaged hyperglycemia, a hallmark of diabetes.

Hyperglycemia occurs in diabetics due to uncontrolled diet, skip diabetes medication and improper use of insulin injection.


The most common complication of diabetes is associated with the damage of tiny blood vessels that nourish the related organ and tissues, leading to the risk for developing microvascular and macrovascular complications. includes
* Cardiovascular disease
* Nerve damage
* Kidney damage
* Eye damage
* Foot damage
And skin problems



Dr. Waqas Sami, in the evaluation of the effect of diet and type 2 diabetes wrote, "Dietary habits and sedentary lifestyle are the major factors for the rapidly rising incidence of DM among developing countries".

And, "In type 2 diabetics, recently, elevated HbA1c level has also been considered as one of the leading risk factors for developing microvascular and macrovascular complications. Improvement in the elevated HbA1c level can be achieved through diet management; thus, the patients could be prevented from developing diabetes complications".

In other words, by following a healthy diet to normalize the levels of HbA1c level, accompanied by moderate exercise, the risk of diabetic complications can be manageable.


Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

On finding a potential compound for the prevention of diabetic complications, researchers examined the effect of alliin, the most abundant sulfur compound in garlic antidiabetic complications against glycation.

Where advanced glycation is considered one of the major pathways associated with the development and progression of a number of diabetic complications including nephropathy, retinopathy, and neuropathy.


Based on the results, alliin exerted a significant effect on glucose and methylglyoxal (MG)-induced by glycation of superoxide dismutase (SOD), which leads to decreased antioxidant enzyme activity, fragmentation/cross-linking in fragment ion association with impaired cross-link, and reduced cross-reactivity with anti-SOD antibodies.

Moreover, the expression of glycation of SOD also leads to the formation of AGEs and fibrils.

In other words, alliin offered protection against elevated levels of glucose or MG-induced glycation of SOD.

Additionally, alliin efficacy against the onset of hyperglycemia was comparable with that of quercetin which is reported to be a potent natural inhibitor of glycation.


Based on the findings, researchers wrote, "Alliin has a good antiglycation effect and hence is expected to have therapeutic potential in the prevention of glycation-mediated diabetic complications".

Taken together, alliin may be considered a supplement for the prevention of glycation-mediated diabetic complications, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Characterization of antioxidant activity of sulfur compounds in black garlic by Wang WD1, Sun YE1, Chen HW. (PubMed)
(2) Inhibitory effect of alliin from Allium sativum on the glycation of superoxide dismutase by Anwar S1, Younus H. (PubMed)
(3) Effect of diet on type 2 diabetes mellitus: A review by Waqas Sami,1,2 Tahir Ansari,3 Nadeem Shafique Butt,4 and Mohd Rashid Ab Hamid. (PMC)

#Phytochemical Betacyanins Exhibit Cytotoxic Effects on #ProstateCancer and #BreastCancer, Researchers Reveal

Kyle J. Norton

The cytotoxic effect is the process of killing cells through toxic substances, particularly in cancer cells.
Chemotherapy is a treatment that uses drugs to treat any disease, including cancer.

Chemo drug also has been used to shrink the tumor before surgery or combined radiotherapy to remove, kill, or damage cancer cells in a certain area,
Chemo travels along the bloodstream to kill cancer cells throughout the whole body.

There are over 100 different types of chemodrugs, including
* Docetaxel (Taxotere), is a type of chemo drug used for the treatment of a chemotherapy drug. It is used to treat many types of cancer including breast, prostate, stomach, head and neck, and non-small cell lung cancer (NSCLC).

* Eribulin (Halaven) is used mostly for the treatment of breast cancer by interfering with cancer cell division and growth.

* Ixabepilone (Ixempra) is used in patients with locally advanced or metastatic breast cancer.


* Paclitaxel (Taxol) has been used for the treatment of used to treat a number of types of cancers, including ovarian cancer, breast cancer, lung cancer, Kaposi sarcoma, cervical cancer, and pancreatic cancer.

* Vinblastine is most commonly used for the treatment of Hodgkin's lymphoma, non-small cell lung cancer, bladder cancer, brain cancer, melanoma, and testicular cancer.

Conventionally, chemo drugs have been found to induce serious side effects, including fatigue due to the loss of healthy cells, hair loss associated with the damage of hair follicles, easy bruising, and bleeding, infection due to the weakened immune system, anemia is caused by the loss of red blood cells, digestive symptoms such as nausea and vomiting, appetite changes, and constipation.

Some of the symptoms may be going away as soon as the treatment stops. However, some symptoms may take months or years after the treatment stops before disappearing

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

In finding a natural compound for the treatment of cancer, researchers examined the extract of red beetroot (Beta vulgaris L.), the FDA-approved red food color E162, cytotoxic effect.
Compared to the chemo drug doxorubicin (adriamycin), betanin, the major betacyanin constituent has been shown to exhibit a dose-dependent cytotoxic effect on human prostate cancer cells (PC-3) and in the well-established estrogen receptor-positive human breast cancer cells (MCF-7), comparable to those of doxorubicin.

In time analysis, although the cytotoxicity of the beetroot extract was significantly lower compared to doxorubicin which completely inhibits the growth of the PC-3 cells in three days, the extract continued to decrease the growth rate of the PC-3 cells (3.7% in 3 days vs. 12.5% in 7 days) at the concentration of 29 µg/ml.

Furthermore, in the normal human skin FC and liver HC cell lines, the extract showed a significantly lower cytotoxic effect compared to doxorubicin (8.6% vs. 100%, respectively, at 29 µg/ml concentration of each, three-day test period).


In chemical differentiation, the efficacy of beetroot extract was attributed to the chemical compound betanin, the major betacyanin constituent in exerting the cytotoxicity.

Based on the finding, researchers said, "Further studies are needed to evaluate the chemopreventive potentials of the beetroot extract when used alone or in combination with doxorubicin to mitigate the toxic side-effects of the latter".

Taken altogether, betacyanins processed as the major bioactive ingredient betanin may be considered a remedy for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer-cell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)

#BrusselsSprouts Inhibit Overexpression of Oxidative Stress Accumulation, Inflammation, Renal Damage, and Proteinuria, Researchers Say

Kyle J. Norton

Hypertension is a condition of abnormally high blood pressure in the bloodstream. Hypertension a member of the cluster conditions of metabolic syndrome associated with an increased risk of cardiovascular disease and diabetes.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

According to the statistics provided by the American Heart Association, approximately, 103 million U.S. adults have high blood pressure, or 1 in 2 adults in the US have the syndrome.


The kidneys are two bean-shaped organs located just below the rib cage, one on each side of your spine.

The kidneys formed a second detoxed organ in the body after the liver not only plays an essential role in regulating electrolytes, and blood pressure, maintains acid-base balance, and produces hormone calcitriol, renin, and erythropoietin,... but also filters blood that passes into the tubules. In the Urinary system, kidneys reabsorb some necessary substances back into the blood, while waste, such as urea and ammonium is deposited into the pelvis and then into the ureter to the bladder for secretion.

Kidney disease is a condition that reduces the function of the kidney acutely or gradually.

Kidney damage is a condition that causes the reduced function of the kidney. Over time untreated kidney damage can induce the formation of scars. Over-expression of kidney scars can lead to kidney disease and kidney failure in severe cases.

According to the statistics, approximately 14 percent of the US population suffers some form of chronic kidney disease (CKD), including 661,000 cases of kidney failure.

Believe it or not, almost half of the individuals with CKD also have diabetes and/or self-reported cardiovascular disease (CVD).


Blood in urine, protein in the urine, kidney stones, kidney infection, kidney pain, hepatitis C, and other forms of kidney diseases are signs of kidney disease that can lead to CKD.

With an aim to find a natural food for the prevention of stroke, researchers examined the effect of Brussels sprouts on the high-sodium/low-potassium-fed stroke-prone spontaneously hypertensive animal model.

Stroke-prone spontaneously hypertensive rat (SHRSP) received the Japanese diet for 4 weeks included in the study was divided into

* Nontreatment group.

* The SHRSP group received a Japanese diet and B. oleracea.

* A third group received a Japanese diet, B. oleracea, and PPARα inhibitor (GW6471).

* A group of SHRSPs fed with a regular diet served as control.


According to the tested analysis, compared to a regular diet, the group treated with a Japanese diet (high-sodium/low-potassium) showed induced increases in oxidative stress, inflammation, and proteinuria, along with glomerular and tubular damage.

The (AMPK/UCP2) pathway associated with the inhibition of ROS production and palmitate-induced apoptosis in endothelial cells was significantly suppressed by the Japanese diet.

However, Japanese diet-induced overexpression of oxidative stress accumulation, inflammation, renal damage, and proteinuria was totally prevented by the administration of Brussels sprouts.

Additionally, injection of Brussels sprouts also promoted the expression of antioxidant enzymes produced by the host observed by the increased level of a gene associated with drug toxicity without affecting the systolic blood pressure (SBP).


Taken together, Brussels sprouts may be considered supplements for the prevention of renal damage progression in hypertension, pending the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP: role of AMPK/PPARα/UCP2 axis by Rubattu S1, Di Castro S, Cotugno M, Bianchi F, Mattioli R, Baima S, Stanzione R, Madonna M, Bozzao C, Marchitti S, Gelosa P, Sironi L, Pignieri A, Maldini M, Giusti AM, Nardini M, Morelli G, Costantino P, Volpe M. (PubMed)

#Honey Inhibits the Growth of Bacteria, Researchers Say

Kyle J. Norton

Scientists may have found a natural alternative for the treatment of bad breath, according to studies. Bad breath also known as halitosis, is a condition caused by an unpleasant odor of the mouth.

The causes of bad breath may result from a combination of food, tobacco products, poor dental hygiene, health problems, dry mouth, oral infections, dental problems, or medications.

However, chemicals produced by some diseases, such as some cancers, and metabolic disorders, can cause a distinctive breath odor.

Chronic reflux of stomach acids (gastroesophageal reflux disease, or GERD) may be considered a major cause of bad breath in older adults.

The most common treatment for bad breath in the Western world is the use of mouth rinses and toothpaste if the bad breath is the result of bacterial infection.


People with bad breath due to loss dentures may need to see their dentists for correction.

However, if bad breath is associated with dental diseases such as gum disease then seeing a related field specialist may be necessary.

Some researchers suggested that obesity is also tied to bad breath. The Tel Aviv University in examining the risk of bad breath in obese wrote, " the more overweight you are, the more likely your breath will smell unpleasant to those around you".

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.

Researchers with an aim to find a natural remedy for the treatment of bad breath examined the Manuka honey anti-oral halitosis activity.

Manuka honey contains the typical antibacterial substance methylglyoxal (MGO) which has been found to process a strong antibacterial activity against oral bacteria.

The study to compare the before and after intake of Manuka honey or Acacia honey and their halitosis effect included 10 healthy subjects (average age: 36 years old, 5 men and 5 women).


The concentrations of volatile sulfur compounds (VSCs) produced by the oral bacteria and anaerobic bacteria in the mouth decreased after intake of both honey, but faster in the Manuka honey compared to those of Acacia honey.

Manuka honey showed a 127 times higher amount of MGO than acacia honey, according to analysis.

These results clearly suggested that the efficacy of honey in the inhibition of bad breath was attributed to the strong antibacterial activity of MGO.

In order to reveal more information about honey's anti-bad breath activity, researchers investigated the effect of honey in preventing gingivitis and dental caries.

In a total of 20 female orthodontic patients between the ages from12–and 18 participated in this randomized controlled study, Researchers compared the effect of honey with either 10% sucrose or 10% sorbitol that served as positive and negative controls.

Honey injection showed significant differences in pH compared to the pH observed in the sorbitol group. The maximum pH drop occurred at 5 min in both the honey and sucrose groups and the pH following sucrose exposure fell <5.5 and was associated with a 30 min recovery time.

Furthermore, bacterial counts were in the honey treatment group significantly reduced compared to the other treatment groups.


Moreover, honey also significantly inhibited the growth of all studied strains compared to the inhibition observed with antibiotics.

Taken together, honey, particularly, Manuka honey or Acacia honey may be considered functional remedies for the prevention and treatment of bad breath, pending the confirmation of a larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Decrease of halitosis by intake of manuka honey by H. SHIGA, A. JO, Keiji Terao Kobe University. (Research Gate)
(2) Effect of honey in preventing gingivitis and dental caries in patients undergoing orthodontic treatment by AL-Dany A. Atwa, a Ramadan Y. AbuShahba, a Marwa Mostafa,b and Mohamed I. Hashemc. (PMC)
(3) Overweight People More Likely To Have Bad Breath, Study Finds by the Tel Aviv University

#Tomato Balances Gut Microbiota For the Improvement of #DigestiveHealth, Researchers Show

Kyle J. Norton

Gut Microbiota is a community of microorganisms living in the gastrointestinal tract.

Under normal conditions, gut microbiota plays a critical role in overall health, including the impacts of
* In nutrient metabolism, gut microbiota improves the absorption of dietary nutrients in the digestive system

* In xenobiotic and drug metabolism, gut microbiota protects the body against xenobiotics and drug toxicity by facilitating the excretion.

* Maintenance of the structural integrity of the gut mucosal barrier, gut microbiota enhances the epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of intestine in nutrients adsorption.

* In immunomodulation, gut microbiota interact with the immune system against inflammatory immune disorders and inhibit the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

However, an imbalanced ratio of gut microbiota may have a negative on human health and diseases.

Dr. Yu-Jie Zhang wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function".

, "However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".

Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods for enhancing the ratio of dut microbiota composition researchers examined the effect of consuming tomato products and lycopene on chronic inflammatory disorders associated with intestinal bacteria in an animal model.

The study included Winnie mice as a model of spontaneous ulcerative colitis treated with or without chow enriched with 1% Bronze tomato.

At week 2, the Bronze-enriched chow-treated group showed no macroscopic effect on the IBD symptoms.

However, levels of pro-inflammatory cytokines found in the treated mice were significantly reduced, as observed by the levels of IL17A and IFNγ.


According to the analysis of the microbial composition, two weeks of Bronze enriched diet demonstrated a strong effect in the improvement of the gut microbiota ratio in the tested mice.


In additional differentiation of the results, researchers found that the efficacy of Bronze tomato in the promotion of gut health was attributed to the phytochemical polyphenols presented in the tomato.

Taken altogether, tomatoes processed with a high amount of lycopene may be considered a dietary supplement for gut health, pending to large sample size and multicenter human study.

Intake of polyphenols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)
(2) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions.
Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(3) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang,1 Sha Li,2 Ren-You Gan,3 Tong Zhou,1 Dong-Ping Xu,1 and Hua-Bin Li. (PMC)

#Herbal #Ginger #Extract Processes Anti Hyperlipidemic Property, Researchers Find

Kyle J. Norton

Hyperlipidemia is abnormally high levels of cholesterol in the bloodstream. The syndrome is a member of the cluster conditions of metabolic syndrome, a leading cause of cardiovascular disease.
Cholesterol, a waxy substance produced either by the liver or food intake plays a critical role in the production of vitamin D, steroid hormones, and the building of the cell walls.


Overexpression cholesterol is a medical condition that causes plaque to accumulate on the arterial wall, leading to the narrowing of the arteries in transport the of oxygenated blood to the parts of the body.

In severe cases, it can cause blood flow blockage, leading to chronic ailments depending on the location of the blood clot.

There are 2 types of blood cholesterol, low-density lipoprotein (LDL) which carries the aforementioned functions, and high-density cholesterol (HDL) which carries cholesterol from the blood back to the liver for future re-use.

The healthy ratio of total blood cholesterol is less than 4 LDL/ 1 HDL.

Most people are diagnosed with high blood cholesterol substantially higher total cholesterol ratio.


Some researchers suggested that the widespread high blood cholesterol in North America is associated with the promotion of the Western diet over the past few decades.


Dr. Kamilah Ali, the lead scientist in the assessment of the Western diet risk of high blood cholesterol in an animal model, wrote, "mice on a C57BL/6 background after receiving a high fat-high cholesterol diet for 12 weeks. ApoD−/− mice had higher HDL-cholesterol levels (61±13-apoD−/− vs. 52±10-WT-males; 37±11-apoD−/− vs. 22±2 WT-female) than WT mice with sex-specific changes in total plasma levels of cholesterol and other lipids".

And, "Compared to WT, the HDL of apoD−/− mice showed an increase in large, lipid-rich HDL particles and according to size various quantities and sizes of LDL particles".

The results suggested that long-term users of the Western diet may be associated with the risk of hyperlipidemia.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.


Researchers on finding a natural compound for the treatment of hyperlipidemia investigated the effect of ginger extracts on alcohol-induced hyperlipidemia and associated myocardial damage.

The study included 24 Wistar male albino rats (250 ± 20 g) divided into four groups including, normal control (NC) (0.9% NaCl), ginger treated (Gt) (200 mg/Kg b.w.), alcohol-treated (At) (20% of 6g/kg b.w. alcohol), and alcohol along with Ginger treatment (At+Gt).
Before ginger administration, alcohol-induced myocardial damage rats showed an increased lipid profile except for high-density lipoprotein compared with control.

Ginger treatment significantly inhibited the alcohol-induced lipid profiles caused by the injection of alcohol except for high-density lipoproteins.

Furthermore, the ginger treatment also inhibited the elevated cardiac biomarkers activity with alcohol intoxication. In other words, ginger treatment for 7 weeks significantly minimized the alcohol-induced myocardial damage.

Dr. Subbaiah GV, the lead scientist said, "Ginger could protect alcohol-induced myocardial damage by suppression of hyperlipidemia and cardiac biomarkers".


In order to reveal more information about ginger's anti-hypolipidemic effects, researchers examined the hypolipidemic effects of a hydroethanolic ginger extract (GE) in the liver of rats fed a high-fat diet (HFD).

The study included male Wistar rats divided into the following 3 groups: (i) Rats fed a standard diet (3.5% fat), the control group; (ii) rats fed an HFD (33.5% fat); and (iii) rats fed an HFD treated with GE (250 mg·kg-1·day-1) for 5 weeks (HFD+GE).

GE improved lipid profile and attenuated the increase of plasma levels of glucose, insulin, and leptin in HFD rats.

In the in-depth analysis, researchers found that ginger antihyperlipidemic activity was attributed to the induction of a higher liver expression of proteins associated with a variety of metabolic processes including lipid and enhanced levels of adiponectin which plays a critical role in preventing dyslipidemia.

Taken together, ginger may be considered a functional remedy for the prevention and treatment of hyperlipidemia with no side effects, pending the confirmation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, Best Before It's News,  Karate and GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
NominShorty Awardrty award over the last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Ginger Treatment Ameliorates Alcohol-induced Myocardial Damage by Suppression of Hyperlipidemia and Cardiac Biomarkers in Rats by Subbaiah GV1, Mallikarjuna K2, Shanmugam B1, Ravi S1, Taj PU1, Reddy KS1. (PubMed)
(2) Molecular factors involved in the hypolipidemic- and insulin-sensitizing effects oa ginger (Zingiber officinale Roscoe) extract in rats fed a high-fat diet by de Las Heras N1, Valero-Muñoz M1, Martín-Fernández B1, Ballesteros S1, López-Farré A2, Ruiz-Roso B3, Lahera V1. (PubMed)
(3) A Western-Fed Diet Increases Plasma HDL and LDL-Cholesterol Levels in ApoD–/– Mice by Kamilah Ali, Ehab M. Abo-Ali, M. D. Kabir, 1 Bethany Riggins, 1 Susanna Nguy, 1Lisa Li, 1 Ujala Srivastava, 1 and Su Mya Mya Thinn. (PMC)

#CranberryJuice improves Rheumatoid Arthritis Symptoms and Decreases the Disease Activity, Researchers Say

Kyle J. Norton

Rheumatoid Arthritis is a chronic disorder characterized by inflammation of the flexible (synovial) joints tissues and organs in the body.
The disease affects more women than men and generally occurs after the age of 40, causing the diminished quality of life of many elders.

According to the statistics provided by the CDC, musculoskeletal disorders (MSDs) affect over 52 million of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.

Rheumatoid arthritis was found to induce bone loss through elevating bone resorption without increasing bone formation.

Patients with rheumatoid arthritis (RA) often associate with valgus deformities of the feet and deformities of gait due to body function due to an effort to support the collapsing longitudinal arch of the foot.

Long-term bone damage and the prolonged onset of the disease can induce deformities of the hand and wrist and small peripheral joints (such as fingers and wrist) due to chronic inflammation.

The effects of muscle strength in patients with RA may contribute to the prevalence of physical functional limitations that can affect daily living and quality of life.

Furthermore, rheumatoid nodules, lumps on the skin, and closed to joint have been found to affect the joints of patients with RA.

Moreover, morning stiffness, a marker of inflammatory activity that reflects functional disability and pain is a very common symptom of patients in the early stage of rheumatoid arthritis.


In finding a potential compound for the treatment of inflammatory disease, researchers examined the effect of cranberry juice consumption on several inflammatory biomarkers and on the disease activity of patients with RA.

The prospective study included 41 women diagnosed with RA.randomly divided into a control group (n = 18) that maintained their usual diet and the cranberry group (n = 23) received 500 mL/d of low-calorie cranberry juice.

Compared to baseline values, the cranberry group showed a decrease in the values of Disease Activity Score 28 (DAS28) (P = 0.048) and anti-cyclic citrullinated peptide (anti-CCP), the antibody present in most rheumatoid arthritis patients (P = 0.034) after 90 d of treatment without affecting the inflammatory biomarkers.

The results strongly suggested that cranberry juice improves rheumatoid arthritis symptoms and decreases the disease activity that benefits RA patients.

Taken together, cranberry may be considered a remedy for the improvement of rheumatoid arthritis, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberry juice decreases disease activity in women with rheumatoid arthritis by Thimóteo NSB1, Iryioda TMV1, Alfieri DF1, Rego BEF1, Scavuzzi BM1, Fatel E2, Lozovoy MAB3, Simão ANC3, Dichi I. (PubMed)