Kyle J. Norton
Scientists may have found a natural alternative for the treatment of asthma, according to studies.
Asthma is a chronic inflammation of the airway of the lung with recurring symptoms. Asthma, attacks triggered by the stimuli can induce airway swelling and inflamed, leading to muscle constriction.
During asthma attacks, patients may experience symptoms of difficulty breathing, severe wheezing in the breath, and coughs that won't stop.
According to the statistics provided by the Centers for Disease Control and Prevention (CDC), 1 in 13 people in the US has asthma.
In other words, more than 26 million Americans have asthma, with half of the patients being children.
If you experience symptoms of a cough which is often worse at night or early in the morning, wheezing in your breath, accompanied by chest tightness and shortness of breath, you may be at the early stage of asthma. Please check with your doctor to rule out the possibility.
Genetic and environmental factors are the most common risk factors associated with the onset of asthma. Some researchers suggested that the widespread obesity over the past few decades may also have a strong implication on the onset of the disease.
Dr. David A. Beuthe r, the lead scientist in the concern of the association of asthma and obesity said, "Cross-sectional and prospective cohort studies of humans have shown a modest overall increase in asthma incidence and prevalence in the obese, although body mass index does not appear to be a significant modifier of asthma severity".
And, "Studying the obesity-asthma relationship in large cohorts, in which self-reports are frequently used to ascertain the diagnosis of asthma, has been complicated by alterations in pulmonary physiology caused by obesity, which may lead to dyspnea or other respiratory symptoms but do not fulfill accepted physiologic criteria for asthma".
These results strongly suggested that if you are obese, your risk of asthma is increased substantially.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners many people.
Scientists on finding a natural remedy for the treatment of asthma investigated the effect of aerosolized honey on airway tissues in a rabbit model of ovalbumin (OVA)-induced asthma.
The study included 40 New Zealand white rabbits sensitized twice with a mixture of OVA and aluminum hydroxide on days 1 and 14.
Honey treatments were given from day 23 to day 25 at two different doses (25% (v/v) and 50% (v/v) of honey diluted in sterile phosphate buffer saline.
During the study, the aerosolized honey treatment group restored the epithelium, mucosa, and submucosal regions of the airway infected by the application of OVA.
Furthermore, the aerosolized honey treatment was also found to reduce the number of airway inflammatory cells present in bronchoalveolar lavage fluid and inhibit goblet cell hyperplasia, an indication of airway remodeling in asthma.
The findings strongly suggested that aerosolized honey has a significant effect on the treatment and management of asthma in animal models.
Additional differentiation of the modulatory effect of honey, royal jelly, and propolis extract on peripheral blood leukocytes and lung inflammation in a mouse conalbumin-induced asthma model in mice model divided into* The mice in group I that were not sensitized or treated; they were kept as controls.
* The mice in group II were sensitized and challenged with conalbumin. Twenty-four hours after the first challenge with antigen.
* The mice in group III received 0.5 mg/kg of dexamethasone intraperitoneally per day for 18 consecutive days and were kept as positive controls.
* The mice in groups IV, V, and VI received 650, 1000, and 30 mg/kg of honey, royal jelly, and propolis (aqueous and ethanolic extract), respectively, once per day for 18 consecutive days.
At the end of the experiment, by comparing the blood samples before and after treatment, researchers showed
* The groups treated with propolis extract exhibited considerable ameliorative effects against asthma, probably due to the expression of flavonoids and phenolics that exert antioxidative effects
* Honey- or royal jelly-treated groups exhibited an increased incidence of asthma cascade events due to increased inflammatory cells, probably due to the antagonist to bronchial asthma cases.
The results clearly indicated that not all honey is the same. Some can be used for asthma while others can not, probably due to types of chemical compounds found in the pollen
Taken together, honey and other bee products may be considered functional remedies for the prevention and treatment of asthma, pending the confirmation of the types of honey in a large and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Inhalation of honey reduces airway inflammation and histopathological changes in a rabbit model of ovalbumin-induced chronic asthma by Kamaruzaman NA, Sulaiman SA, Kaur G, Yahaya B1. (PubMed)
(2) Evaluation of propolis, honey, and royal jelly in amelioration of peripheral blood leukocytes and lung inflammation in mouse conalbumin-induced asthma model by El-Aidy WK1, Ebeid AA1, Sallam Ael-R1, Muhammad IE2, Abbas AT3, Kamal MA4, Sohrab SS. (PubMed)
(3) Obesity and Asthma by David A. Beuther, Scott T. Weiss, and E. Rand Sutherland. (PMC)
Sunday, 3 September 2023
#Turmeric #Extract Inhibits Hepatic (Liver) Stress Associated with the Risk of Liver Injury, Researchers Say
Kyle J. Norton
The liver is the largest internal organ that not only filters the blood from the digestive system before passing them to other parts of the body but also plays a critical role in the production cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.
Hepatic stress is a condition in which the function of the liver is partly reduced. Hepatic stress can be observed by the levels of liver stress-makers.
Liver function tests (LFTs or LFs) are used to measure the levels of liver transaminases aspartate transaminase (AST) and alanine transaminase (ALT) in patients with liver injury, particularly, in a patient with some degree of intact liver function.
Abnormal high levels of transaminases aspartate transaminase (AST) and alanine transaminase (ALT) are early indications of liver damage or injury.
Oxidative stress in the liver caused by a toxic substance such as an overdose of the supplement has been found to constitute most cases of acute liver damage.
Lauren Cooper, the author in the examine the toxic effects of an overdose of green tea extract and bodybuilding pills wrote, "Many herbal remedies and dietary supplements can also harm the liver, including some that you can easily buy online or over-the-counter in drug or health food stores".
And, "Researchers looked at cases of liver damage reported to the Drug-Induced Liver Injury Network, a program funded by the National Institutes of Health. Roughly 700 cases of liver damage were reported to the program during the period of the study; 130 of those cases were linked to dietary supplements".
The results strongly suggested although green tea extract is considered a functional supplement for the treatment of various diseases, overdose and abusive use of such supplements also have a negative impact on human health, particularly in liver health.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an antioxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential compound for the improvement of liver functioning, researchers examined the effect of Curcuma longa L. (CLL) rhizome on hepatic dysfunction.
In acute carbon tetrachloride (CCl4)-induced liver stress rats, researchers compared the activity of CLL extract administered once a day for 3 days at three dose levels (100, 200, and 300 mg/kg/day) and curcumin administered once a day at the 200 mg/kg/day.
Before treatment, CCl4 rats showed a significant induced increased serum AST and ALT levels by 2.1- and 1.2-fold, respectively, compared with the control.
CLL- and curcumin-treated rats inhibited the levels of AST but not ALT elevation induced by CCl4.
Furthermore, according to the tested assays, the peroxidation of membrane lipids in the liver was significantly prevented by CLL (100, 200, and 300 mg/kg/day) on liver tissues.
Moreover, both CLL extract and curcumin exhibited significant protection against liver injury by improving the levels of hepatic antioxidant enzymes such as superoxide dismutase and glutathione peroxidase, and glutathione against free radicals expression in the CCl4 treated rats.
More precisely, both CLL extract and curcumin protected the liver cells against the onset of liver cellular stress through reducing the liver damage markers and inhibiting the liver oxidative stress via increased production of liver antioxidant enzymes.
Dr. Lee GH, the lead scientist said, "Our data suggested that CLL extract and curcumin protect the liver from acute CCl4-induced injury in a rodent model by suppressing hepatic oxidative stress. Therefore, CLL extract and curcumin are potential therapeutic antioxidant agents against acute hepatotoxicity".
Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the improvement of liver functioning against liver damage, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin and Curcuma longa L. extract ameliorates lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress by Lee HY1, Kim SW2, Lee GH1, Choi MK1, Chung HW1, Lee YC3, Kim HR4, Kwon HJ5, Chae HJ. (PubMed)
(2) Protective effect of Curcuma longa L. extracts on CCl4-induced acute hepatic stress by Lee GH1, Lee HY1, Choi MK1, Chung HW1, Kim SW2,3, Chae HJ. (PubMed)
(3) Liver Damage From Supplements Is on the Rise. Green-tea extract and bodybuilding pills pose a particular risk, study finds By Lauren Cooper. (CR)
The liver is the largest internal organ that not only filters the blood from the digestive system before passing them to other parts of the body but also plays a critical role in the production cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.
Hepatic stress is a condition in which the function of the liver is partly reduced. Hepatic stress can be observed by the levels of liver stress-makers.
Liver function tests (LFTs or LFs) are used to measure the levels of liver transaminases aspartate transaminase (AST) and alanine transaminase (ALT) in patients with liver injury, particularly, in a patient with some degree of intact liver function.
Abnormal high levels of transaminases aspartate transaminase (AST) and alanine transaminase (ALT) are early indications of liver damage or injury.
Oxidative stress in the liver caused by a toxic substance such as an overdose of the supplement has been found to constitute most cases of acute liver damage.
Lauren Cooper, the author in the examine the toxic effects of an overdose of green tea extract and bodybuilding pills wrote, "Many herbal remedies and dietary supplements can also harm the liver, including some that you can easily buy online or over-the-counter in drug or health food stores".
And, "Researchers looked at cases of liver damage reported to the Drug-Induced Liver Injury Network, a program funded by the National Institutes of Health. Roughly 700 cases of liver damage were reported to the program during the period of the study; 130 of those cases were linked to dietary supplements".
The results strongly suggested although green tea extract is considered a functional supplement for the treatment of various diseases, overdose and abusive use of such supplements also have a negative impact on human health, particularly in liver health.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an antioxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential compound for the improvement of liver functioning, researchers examined the effect of Curcuma longa L. (CLL) rhizome on hepatic dysfunction.
In acute carbon tetrachloride (CCl4)-induced liver stress rats, researchers compared the activity of CLL extract administered once a day for 3 days at three dose levels (100, 200, and 300 mg/kg/day) and curcumin administered once a day at the 200 mg/kg/day.
Before treatment, CCl4 rats showed a significant induced increased serum AST and ALT levels by 2.1- and 1.2-fold, respectively, compared with the control.
CLL- and curcumin-treated rats inhibited the levels of AST but not ALT elevation induced by CCl4.
Furthermore, according to the tested assays, the peroxidation of membrane lipids in the liver was significantly prevented by CLL (100, 200, and 300 mg/kg/day) on liver tissues.
Moreover, both CLL extract and curcumin exhibited significant protection against liver injury by improving the levels of hepatic antioxidant enzymes such as superoxide dismutase and glutathione peroxidase, and glutathione against free radicals expression in the CCl4 treated rats.
More precisely, both CLL extract and curcumin protected the liver cells against the onset of liver cellular stress through reducing the liver damage markers and inhibiting the liver oxidative stress via increased production of liver antioxidant enzymes.
Dr. Lee GH, the lead scientist said, "Our data suggested that CLL extract and curcumin protect the liver from acute CCl4-induced injury in a rodent model by suppressing hepatic oxidative stress. Therefore, CLL extract and curcumin are potential therapeutic antioxidant agents against acute hepatotoxicity".
Taken together, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the improvement of liver functioning against liver damage, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin and Curcuma longa L. extract ameliorates lipid accumulation through the regulation of the endoplasmic reticulum redox and ER stress by Lee HY1, Kim SW2, Lee GH1, Choi MK1, Chung HW1, Lee YC3, Kim HR4, Kwon HJ5, Chae HJ. (PubMed)
(2) Protective effect of Curcuma longa L. extracts on CCl4-induced acute hepatic stress by Lee GH1, Lee HY1, Choi MK1, Chung HW1, Kim SW2,3, Chae HJ. (PubMed)
(3) Liver Damage From Supplements Is on the Rise. Green-tea extract and bodybuilding pills pose a particular risk, study finds By Lauren Cooper. (CR)
#Cucumber Potentially Used in the Management of Knee Pain, Stiffness, and Physical Functions Related to #Osteoarthritis
Kyle J. Norton
Osteoarthritis (OA) is a chronic condition affecting the joints in the hands, knees, hips, and spine mostly occurring in older adults.
More precisely, OA is a result in which the protective cartilage on the ends of your bones wears down over time due to repetitive movement of the same joints that cause the thinning cartilage, leading to bone rubbing on bone.
According to the statistics, in the US, over 25 million people are living with OA.
The precisive characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in a change of weather, at night, and in advanced diseases, the pain can occur even at rest(8).
Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments(4).
Believe it or not, other causes of OA also include
1. Process of wear and repair
Osteoarthritis (OA), is a widespread degenerative disease of skeletal joints(34) and is often associated with senescence invertebrates. arising from long-term wear and tear, heavy long-term use, or specific injuries(35).
The improper repair process of injuring joints can also result in symptoms of Osteoarthritis (OA)(36) in old age(37), according to TCM.
2. Nutrient deficiency and overload
Poor nutritional conditions experienced early in life are linked to the greater prevalence of osteoarthritis (OA)(35)(38), such as vitamin D.
On the other hand, nutrient overload and metabolic surplus, such as obesity may contribute to the early onset of osteoarthritis (OA)(38).
3. Cartilage
Cartilage is a flexible connective tissue that cushions the ends of bones in your joints and allows the joints to move smoothly. Rough or worn down cartilage due to aging or damage can cause pain due to the bone in the joint rubbing against another bone(39)(40).
In other words, osteoarthritis (OA) may also be the result of injury (35), overuse(15)(16), Rheumatoid Arthritis(41), etc.
The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae, native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
With an aim to find a potential compound for the treatment of osteoarthritis, researchers evaluated the efficacy of Q-Actin™, an aqueous extract of Cucumis sativus (cucumber; CSE) against glucosamine-chondroitin (GC) in the management of moderate knee OA.
The randomized double-blind, parallel-group clinical trial took place in three different centers. included 122 patients (56 males and 66 females) aged between 40 and 75 years and diagnosed with moderate knee OA assigned to 2 groups (n= 61).
Among the groups, the GC group received orally the generally prescribed dose of 1,350 mg of GC twice daily and the CSE group received orally 10 mg twice daily of CSE.
According to the assays, on days 30, 60, 90, 120, 150, and 180 compared to the baseline (Day 0), the WOMAC score in the CSE group was decreased by 22.44% and 70.29% on days 30 and 180, respectively, compared to a 14.80% and 32.81% respectively decrease in the GC group.
The pain scores also showed similar trends in flavor to the CSE group. There was no adverse effect on the course of the experiment.
In other words, CSE is more effective for the treatment of OA compared to that of GC.
Dr. the lead scientists wrote, "The use of 10 mg CSE, twice daily, was effective in reducing pain related to moderate knee OA and can be potentially used in the management of knee pain, stiffness, and physical functions related to OA".
Taken together, cucumber extract may be used for the treatment of OA, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial by Nash RJ1, Azantsa BK2, Sharp H1, Shanmugham V. (PubMed)
(2) Most Common Disease of elder: The Clinical Trials and Studies of Musculoskeletal Disorders (MSDs) - Osteoarthritis: The Causes and Risk Factors by Kyle J. Norton
Osteoarthritis (OA) is a chronic condition affecting the joints in the hands, knees, hips, and spine mostly occurring in older adults.
More precisely, OA is a result in which the protective cartilage on the ends of your bones wears down over time due to repetitive movement of the same joints that cause the thinning cartilage, leading to bone rubbing on bone.
According to the statistics, in the US, over 25 million people are living with OA.
The precisive characteristics of osteoarthritis are aching pain(5), stiffness(6), or difficulty of moving the joint or joints(7). The pain usually gets worse in a change of weather, at night, and in advanced diseases, the pain can occur even at rest(8).
Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments(4).
Believe it or not, other causes of OA also include
1. Process of wear and repair
Osteoarthritis (OA), is a widespread degenerative disease of skeletal joints(34) and is often associated with senescence invertebrates. arising from long-term wear and tear, heavy long-term use, or specific injuries(35).
The improper repair process of injuring joints can also result in symptoms of Osteoarthritis (OA)(36) in old age(37), according to TCM.
2. Nutrient deficiency and overload
Poor nutritional conditions experienced early in life are linked to the greater prevalence of osteoarthritis (OA)(35)(38), such as vitamin D.
On the other hand, nutrient overload and metabolic surplus, such as obesity may contribute to the early onset of osteoarthritis (OA)(38).
3. Cartilage
Cartilage is a flexible connective tissue that cushions the ends of bones in your joints and allows the joints to move smoothly. Rough or worn down cartilage due to aging or damage can cause pain due to the bone in the joint rubbing against another bone(39)(40).
In other words, osteoarthritis (OA) may also be the result of injury (35), overuse(15)(16), Rheumatoid Arthritis(41), etc.
The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae, native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
With an aim to find a potential compound for the treatment of osteoarthritis, researchers evaluated the efficacy of Q-Actin™, an aqueous extract of Cucumis sativus (cucumber; CSE) against glucosamine-chondroitin (GC) in the management of moderate knee OA.
The randomized double-blind, parallel-group clinical trial took place in three different centers. included 122 patients (56 males and 66 females) aged between 40 and 75 years and diagnosed with moderate knee OA assigned to 2 groups (n= 61).
Among the groups, the GC group received orally the generally prescribed dose of 1,350 mg of GC twice daily and the CSE group received orally 10 mg twice daily of CSE.
According to the assays, on days 30, 60, 90, 120, 150, and 180 compared to the baseline (Day 0), the WOMAC score in the CSE group was decreased by 22.44% and 70.29% on days 30 and 180, respectively, compared to a 14.80% and 32.81% respectively decrease in the GC group.
The pain scores also showed similar trends in flavor to the CSE group. There was no adverse effect on the course of the experiment.
In other words, CSE is more effective for the treatment of OA compared to that of GC.
Dr. the lead scientists wrote, "The use of 10 mg CSE, twice daily, was effective in reducing pain related to moderate knee OA and can be potentially used in the management of knee pain, stiffness, and physical functions related to OA".
Taken together, cucumber extract may be used for the treatment of OA, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial by Nash RJ1, Azantsa BK2, Sharp H1, Shanmugham V. (PubMed)
(2) Most Common Disease of elder: The Clinical Trials and Studies of Musculoskeletal Disorders (MSDs) - Osteoarthritis: The Causes and Risk Factors by Kyle J. Norton
#Carotenoids Reduce the Implication of the Toxic ROS Expression that Causes #CysticFibrosis (CF), Researchers Find
Kyle J. Norton
Cystic fibrosis (CF) is the most common fatal genetic disease affecting mostly the lung in Canadian children and young adults, leading to difficulty breathing and coughing up mucus and frequent lung infections.
However, the condition has also been found in the pancreas, liver, kidneys, and intestine.
According to the Cystic Fibrosis Foundation Patient Registry, more than 30,000 people are living with cystic fibrosis in the US.
Believe it or not, most cases of CF are diagnosed by age 2.
The most common symptoms depend on the location of cystic fibrosis including
sinus infections, poor growth, fatty stool, and clubbing of the fingers and toes.
In male adults, the condition also induces infertility as a result of the blockage or absence of the sperm canal.
Conventionally, as of today, there is no cure for CF. Most cases of CF caused by lung infection are treated intravenously, inhaled, or by mouth.
In severe cases, a lung transplant may be the only option.
Although most cases of CF are associated with a genetic preposition, environment, lifestyle, and age are also 2 main factors that increase the risk of CF.
Cystic Fibrosis Canada in the investigation of the risk of CF in older adults wrote, "Today, the estimated median age of survival of CF patients in Canada is over 50 years, and the majority of patients are over 18 years of age. CF patients enjoy an improved quality of life, pursuing careers, and starting families of their own".
Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
In finding a potential compound for the treatment of lung disease researchers examined the effects of carotenoids, the potent antioxidants on singlet oxygen and other toxic oxygen species in patients with cystic fibrosis (CF).
The study included a total of 17 patients with cystic fibrosis (CF) and 10 normal children,
According to the assessment of plasma levels of four carotenoids, beta-carotene, alpha-carotene, lutein, and lycopene, levels of carotenoids in children with CF were significantly lower compared to normal control participants.
There was no significant difference in total cholesterol and total carotene between groups. Furthermore, there was no correlation between fat absorption or measures of adiposity in children with CF compared to control.
However, levels of selected carotenoids were correlated negatively with serum IgG levels associated with the measurement of inflammation.
More importantly, researchers also found that the differences in plasma carotenoid levels between children with CF and normal children were involved in the rapid turnover of carotenoids, by quenching of toxic oxygen species in inflammatory states of CF.
The results strongly suggested that improving the concentration of carotenoids that reduces the implication of the toxic ROS expression may have an impact on the prevention and treatment of CF.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Carotenoid levels in normal children and in children with cystic fibrosis by Homnick DN1, Cox JH, DeLoof MJ, Ringer TV. (PubMed)
(2) Living Longer WITH CYSTIC FIBROSIS by The Cystic Fibrosis Canada
Cystic fibrosis (CF) is the most common fatal genetic disease affecting mostly the lung in Canadian children and young adults, leading to difficulty breathing and coughing up mucus and frequent lung infections.
However, the condition has also been found in the pancreas, liver, kidneys, and intestine.
According to the Cystic Fibrosis Foundation Patient Registry, more than 30,000 people are living with cystic fibrosis in the US.
Believe it or not, most cases of CF are diagnosed by age 2.
The most common symptoms depend on the location of cystic fibrosis including
sinus infections, poor growth, fatty stool, and clubbing of the fingers and toes.
In male adults, the condition also induces infertility as a result of the blockage or absence of the sperm canal.
Conventionally, as of today, there is no cure for CF. Most cases of CF caused by lung infection are treated intravenously, inhaled, or by mouth.
In severe cases, a lung transplant may be the only option.
Although most cases of CF are associated with a genetic preposition, environment, lifestyle, and age are also 2 main factors that increase the risk of CF.
Cystic Fibrosis Canada in the investigation of the risk of CF in older adults wrote, "Today, the estimated median age of survival of CF patients in Canada is over 50 years, and the majority of patients are over 18 years of age. CF patients enjoy an improved quality of life, pursuing careers, and starting families of their own".
Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
In finding a potential compound for the treatment of lung disease researchers examined the effects of carotenoids, the potent antioxidants on singlet oxygen and other toxic oxygen species in patients with cystic fibrosis (CF).
The study included a total of 17 patients with cystic fibrosis (CF) and 10 normal children,
According to the assessment of plasma levels of four carotenoids, beta-carotene, alpha-carotene, lutein, and lycopene, levels of carotenoids in children with CF were significantly lower compared to normal control participants.
There was no significant difference in total cholesterol and total carotene between groups. Furthermore, there was no correlation between fat absorption or measures of adiposity in children with CF compared to control.
However, levels of selected carotenoids were correlated negatively with serum IgG levels associated with the measurement of inflammation.
More importantly, researchers also found that the differences in plasma carotenoid levels between children with CF and normal children were involved in the rapid turnover of carotenoids, by quenching of toxic oxygen species in inflammatory states of CF.
The results strongly suggested that improving the concentration of carotenoids that reduces the implication of the toxic ROS expression may have an impact on the prevention and treatment of CF.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Carotenoid levels in normal children and in children with cystic fibrosis by Homnick DN1, Cox JH, DeLoof MJ, Ringer TV. (PubMed)
(2) Living Longer WITH CYSTIC FIBROSIS by The Cystic Fibrosis Canada
#Cucumber #Extract Induces Gastric/#StomachCancer Cell Apoptosis, Researchers Say
Kyle J. Norton
Gastric or mouth cancer is a chronic medical condition characterized by abnormal cells growing in the tissues of the stomach.
The stomach-formed part of the digestive system is located between the esophagus and the small intestine and is a muscular, hollow of the digestive tract.
Most cases of gastric or mouth cancer start in the mucus-producing cells of the inside lining of the stomach due to the alternation of DNA. Adenocarcinoma is the most common type of gastric cancer.
At the early stage, due to the small size of the tumor, most patients with gastric cancer are asymptomatic.
However, as cancer continues to grow, it may induce general symptoms shared by all cancers and specific symptoms such as mild aches in the upper part of the body, difficulty swallowing, feeling full or bloated after a small meal, vomiting blood, or having blood in the stool.
At this stage, gastric cancer also induces secondary metastasis, by infecting other healthy tissues and organs far away from the original site.
Out of many risk factors associated with the onset of gastric cancer including diet, long-term inflammation of the stomach, smoking, and obesity, some researchers suggested low levels of gastric acid production by the stomach may have a strong implication in facilitating the onset of the condition.
Dr. Helge L. Waldum, the lead scientist in the analysis of the correlation between Helicobacter pylori and gastric acid, wrote, "Helicobacter pylori (Hp) is the main cause of gastritis, peptic ulcer disease, and gastric cancer. There are still unanswered questions related to the interaction between HP and man, like what determines the susceptibility for the initial infection and the mechanisms for the carcinogenic effect".
And, "The initial infection seems to require a temporal gastric hypoacidity. For HP to survive in the gastric mucous layer, some acidity is necessary. HP itself is probably not directly carcinogenic. Only when inducing oxyntic mucosal inflammation and atrophy with hypoacidity, Hp predisposes for gastric cancer. Gastrin most likely plays a central role in the Hp pathogenesis of duodenal ulcer and gastric cancer".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is also a creeping vine with roots in the ground and grows with the support of frames.
With an aim to find a potential compound for the treatment of gastric cancer, researchers examined the effect of Ecballium elaterium (L.) A. Rich (Cucurbitaceae) (squirting cucumber) on cell lines of gastric and esophageal origin namely called AGS (human gastric carcinoma) and KYSE30 (human esophageal squamous cell carcinoma).
The study included AGS and KYSE30 cancer cell lines incubated for 24, 48, and 72 h with an aqueous extract of the fruits of E. elaterium prepared and freeze-dried.
In AGS, at the IC(50) values of 2.5, 0.7, and 0.7 μg/ml, the aqueous extract for the cell line after 24, 48, and 72 h, respectively showed significant induction of cell apoptosis.
Similarly, KYSE30 cell line-induced apoptosis was found at IC(50) values for the KYSE30 cell line in doses of 500, 150, and 125 μg/ml after 24, 48, and 72 h, respectively.
Furthermore, the injection of the extract also showed a significant increase in cell density at the G2/M phase, according to cell cycle analysis.
Moreover, the efficacy of the extract against gastric cancer cell lines was attributed to several compounds in the induction of cytotoxicity.
Based on the findings, researchers said, "The results of the current study showed that the freeze-dried aqueous extract of E. elaterium fruit has a cytotoxic effect on gastric and esophageal cancer cell lines by means of apoptosis".
In order to reveal more information of cucumber anti-gastric cancer activity, researchers investigated the effects of Cucurbitacin B (CuB), a natural compound found in Cucurbitaceae in cisplatin (DDP)-resistant human GC cell line SGC7901/DDP.
According to the tested assays, CuB treatment significantly suppressed SGC7901/DDP cell proliferation and induced caspase-dependent apoptosis, and autophagy.
Interestingly, the activation of autophagy was mediated through CuB- inhibition of the protein (TORC1) involved in the regulation of cancer cell growth and survival.
In order to reveal more information about CuB anti-gastric cancer potency, scientists examined the CuB activity as a cancerous inhibitor of protein phosphatase 2A (CIP2A), a human oncoprotein that is overexpressed in multiple kinds of tumors including gastric cancer (GC).
In cisplatin (DDP)-resistant human GC cell line SGC7901/DDP, CuB treatment exerted a similar effect as of that of the aforementioned study in the inhibition of SGC7901/DDP cell proliferation, induced caspase-dependent apoptosis, and autophagy.
Moreover, CuB inhibited mTORC1 as showed in the previous study via the inhibition of CIP2A which activates the protein phosphatase 2A (PP2A) in the induction of cancer cell proliferation.
Based on the results, researchers said, "CuB can inhibit the proliferation, induce caspase-dependent apoptosis, and autophagy of SGC7901/DDP cells by suppressing CIP2A/PP2A/mTORC1 signaling axis".
Taken together, cucumber processed with a high amount of Cucurbitacin B (CuB) as the main ingredient may be considered supplements for the prevention and treatment of gastric cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of Cucurbitacin B (CuB) in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytotoxic effect of freeze-dried extract of Ecballium elaterium fruit on gastric adenocarcinoma (AGS) and esophageal squamous cell carcinoma (KYSE30) cell lines by Bohlooli S1, Jafari N, Jahed S. (PubMed)
(2) Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancercells by Liu X1, Duan C1, Ji J1, Zhang T1, Yuan X1, Zhang Y1, Ma W1, Yang J2, Yang L2, Jiang Z2, Yu H2, Liu Y1. (PubMed)
(3) Helicobacter pylori and gastric acid: an intimate and reciprocal relationship by Helge L. Waldum, Per M. Kleveland, and Øystein F. Sørdal. (PMC)
Gastric or mouth cancer is a chronic medical condition characterized by abnormal cells growing in the tissues of the stomach.
The stomach-formed part of the digestive system is located between the esophagus and the small intestine and is a muscular, hollow of the digestive tract.
Most cases of gastric or mouth cancer start in the mucus-producing cells of the inside lining of the stomach due to the alternation of DNA. Adenocarcinoma is the most common type of gastric cancer.
At the early stage, due to the small size of the tumor, most patients with gastric cancer are asymptomatic.
However, as cancer continues to grow, it may induce general symptoms shared by all cancers and specific symptoms such as mild aches in the upper part of the body, difficulty swallowing, feeling full or bloated after a small meal, vomiting blood, or having blood in the stool.
At this stage, gastric cancer also induces secondary metastasis, by infecting other healthy tissues and organs far away from the original site.
Out of many risk factors associated with the onset of gastric cancer including diet, long-term inflammation of the stomach, smoking, and obesity, some researchers suggested low levels of gastric acid production by the stomach may have a strong implication in facilitating the onset of the condition.
Dr. Helge L. Waldum, the lead scientist in the analysis of the correlation between Helicobacter pylori and gastric acid, wrote, "Helicobacter pylori (Hp) is the main cause of gastritis, peptic ulcer disease, and gastric cancer. There are still unanswered questions related to the interaction between HP and man, like what determines the susceptibility for the initial infection and the mechanisms for the carcinogenic effect".
And, "The initial infection seems to require a temporal gastric hypoacidity. For HP to survive in the gastric mucous layer, some acidity is necessary. HP itself is probably not directly carcinogenic. Only when inducing oxyntic mucosal inflammation and atrophy with hypoacidity, Hp predisposes for gastric cancer. Gastrin most likely plays a central role in the Hp pathogenesis of duodenal ulcer and gastric cancer".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is also a creeping vine with roots in the ground and grows with the support of frames.
With an aim to find a potential compound for the treatment of gastric cancer, researchers examined the effect of Ecballium elaterium (L.) A. Rich (Cucurbitaceae) (squirting cucumber) on cell lines of gastric and esophageal origin namely called AGS (human gastric carcinoma) and KYSE30 (human esophageal squamous cell carcinoma).
The study included AGS and KYSE30 cancer cell lines incubated for 24, 48, and 72 h with an aqueous extract of the fruits of E. elaterium prepared and freeze-dried.
In AGS, at the IC(50) values of 2.5, 0.7, and 0.7 μg/ml, the aqueous extract for the cell line after 24, 48, and 72 h, respectively showed significant induction of cell apoptosis.
Similarly, KYSE30 cell line-induced apoptosis was found at IC(50) values for the KYSE30 cell line in doses of 500, 150, and 125 μg/ml after 24, 48, and 72 h, respectively.
Furthermore, the injection of the extract also showed a significant increase in cell density at the G2/M phase, according to cell cycle analysis.
Moreover, the efficacy of the extract against gastric cancer cell lines was attributed to several compounds in the induction of cytotoxicity.
Based on the findings, researchers said, "The results of the current study showed that the freeze-dried aqueous extract of E. elaterium fruit has a cytotoxic effect on gastric and esophageal cancer cell lines by means of apoptosis".
In order to reveal more information of cucumber anti-gastric cancer activity, researchers investigated the effects of Cucurbitacin B (CuB), a natural compound found in Cucurbitaceae in cisplatin (DDP)-resistant human GC cell line SGC7901/DDP.
According to the tested assays, CuB treatment significantly suppressed SGC7901/DDP cell proliferation and induced caspase-dependent apoptosis, and autophagy.
Interestingly, the activation of autophagy was mediated through CuB- inhibition of the protein (TORC1) involved in the regulation of cancer cell growth and survival.
In order to reveal more information about CuB anti-gastric cancer potency, scientists examined the CuB activity as a cancerous inhibitor of protein phosphatase 2A (CIP2A), a human oncoprotein that is overexpressed in multiple kinds of tumors including gastric cancer (GC).
In cisplatin (DDP)-resistant human GC cell line SGC7901/DDP, CuB treatment exerted a similar effect as of that of the aforementioned study in the inhibition of SGC7901/DDP cell proliferation, induced caspase-dependent apoptosis, and autophagy.
Moreover, CuB inhibited mTORC1 as showed in the previous study via the inhibition of CIP2A which activates the protein phosphatase 2A (PP2A) in the induction of cancer cell proliferation.
Based on the results, researchers said, "CuB can inhibit the proliferation, induce caspase-dependent apoptosis, and autophagy of SGC7901/DDP cells by suppressing CIP2A/PP2A/mTORC1 signaling axis".
Taken together, cucumber processed with a high amount of Cucurbitacin B (CuB) as the main ingredient may be considered supplements for the prevention and treatment of gastric cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of Cucurbitacin B (CuB) in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytotoxic effect of freeze-dried extract of Ecballium elaterium fruit on gastric adenocarcinoma (AGS) and esophageal squamous cell carcinoma (KYSE30) cell lines by Bohlooli S1, Jafari N, Jahed S. (PubMed)
(2) Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancercells by Liu X1, Duan C1, Ji J1, Zhang T1, Yuan X1, Zhang Y1, Ma W1, Yang J2, Yang L2, Jiang Z2, Yu H2, Liu Y1. (PubMed)
(3) Helicobacter pylori and gastric acid: an intimate and reciprocal relationship by Helge L. Waldum, Per M. Kleveland, and Øystein F. Sørdal. (PMC)
#Cucumber #Cucurbitacin B, Eliminates the Apoptosis Resistance of Burkitt's lymphoma Ramos Cells in Vitro, According to Studies
Kyle J. Norton
Lymphoma is a medical and chronic condition associated with abnormal growth of lymphocytes, a type of white blood cells of the immune system that fight infection.
Lymphocytes included natural killer cells T cells and B cells are found in the lymph nodes, spleen, thymus, bone marrow, and other parts of the body.
The condition can be classified into 2 types
* Non-Hodgkin is the common form of lymphoma found in most patients.
* Hodgkin
According to the statistics, in the US, this year, approximately, 8,000 people will be diagnosed with Hodgkin lymphoma, leading to the death of 1,000 patients with the disease.
Believe it or not, Hodgkin's lymphoma is treatable, especially in its early stages. The 5-year survival rate for all patients diagnosed with Hodgkin's lymphoma is 92%.
Most cases of non-Hodgkin lymphoma are found in adults 65 years of age and over compared to the age of 15 and 40 or older than 55 in Hodgkin lymphoma.
People with a weakened immune system, autoimmunity, viral infectious disease, family history, exposure to benzene and radiotherapy, and past history of Hodgkin or non-Hodgkin lymphoma are some factors that may increase the risk of the disease.
Some researchers suggested that genetic proposition may have a strong implication with the onset of lymphoma.
Dr. Robert E. Ferrell, the lead scientist wrote, "Hereditary or primary lymphedema is a developmental disorder of the lymphatic system which leads to a disabling and disfiguring swelling of the extremities"
And, " Hereditary lymphedema generally shows an autosomal dominant pattern of inheritance with reduced penetrance, variable expression and variable age at onset".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
In finding a natural and potential compound for the treatment of lymphoma, researchers examined the effect of Cucurbitacin B (CuB) as an ATO and STAT3 inhibitor against lymphoma.
Where Arsenic trioxide (ATO) is a chemotherapy drug used for the treatment of acute myeloid leukemia.
And STAT3 is a protein that regulates genes involved in cell growth and division.
Injection of CuB was shown to eliminate the apoptosis resistance of Burkitt's lymphoma Ramos cells to ATO synergistically.
In other words, CuB enhanced the drug effects in the inhibition of lymphoma, particularly in resistance to Burkitt's lymphoma Ramos cells.
The results were attributed to the bioactive compound that blocks the activation of protein STAT3 associated with cancer cell proliferation and modulates the expression of proteins involved in pro and anti-apoptosis.
Interestingly, the combination of CuB and ATO kills cancer cells without causing harm to normal cell lines.
In the nude murine lymphoma model, the synergistic effect of the combination of CuB and ATO was once again confirmed by exhibiting significant apoptosis induction and tumor growth inhibition.
Dr. Ding X, the lead scientist said, "CuB synergistically enhances the apoptosis-inducing effect of ATO by inhibiting STAT3 phosphorylation in Ramos cells".
Taken together, cucumber combined with primary medicine may be used for the treatment of lymphoma, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells.
Ding X1,2, Chi J1,2, Yang X1,2, Hao J1,2, Liu C1,2, Zhu C1,2, Wang X1,2, Liu X1,2, Niu Y1,2, Ji W3, Chen D4, Wu X. (PubMed)
(2) Hereditary Lymphedema: Evidence for Linkage and Genetic Heterogeneity by Robert E. Ferrell Kara L. Levinson Judith H. Esman Mark A. KimakElizabeth C. Lawrence M. Michael Barmada David N. Finegold. (Oxford Academic)
Lymphoma is a medical and chronic condition associated with abnormal growth of lymphocytes, a type of white blood cells of the immune system that fight infection.
Lymphocytes included natural killer cells T cells and B cells are found in the lymph nodes, spleen, thymus, bone marrow, and other parts of the body.
The condition can be classified into 2 types
* Non-Hodgkin is the common form of lymphoma found in most patients.
* Hodgkin
According to the statistics, in the US, this year, approximately, 8,000 people will be diagnosed with Hodgkin lymphoma, leading to the death of 1,000 patients with the disease.
Believe it or not, Hodgkin's lymphoma is treatable, especially in its early stages. The 5-year survival rate for all patients diagnosed with Hodgkin's lymphoma is 92%.
Most cases of non-Hodgkin lymphoma are found in adults 65 years of age and over compared to the age of 15 and 40 or older than 55 in Hodgkin lymphoma.
People with a weakened immune system, autoimmunity, viral infectious disease, family history, exposure to benzene and radiotherapy, and past history of Hodgkin or non-Hodgkin lymphoma are some factors that may increase the risk of the disease.
Some researchers suggested that genetic proposition may have a strong implication with the onset of lymphoma.
Dr. Robert E. Ferrell, the lead scientist wrote, "Hereditary or primary lymphedema is a developmental disorder of the lymphatic system which leads to a disabling and disfiguring swelling of the extremities"
And, " Hereditary lymphedema generally shows an autosomal dominant pattern of inheritance with reduced penetrance, variable expression and variable age at onset".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows with the support of frames.
In finding a natural and potential compound for the treatment of lymphoma, researchers examined the effect of Cucurbitacin B (CuB) as an ATO and STAT3 inhibitor against lymphoma.
Where Arsenic trioxide (ATO) is a chemotherapy drug used for the treatment of acute myeloid leukemia.
And STAT3 is a protein that regulates genes involved in cell growth and division.
Injection of CuB was shown to eliminate the apoptosis resistance of Burkitt's lymphoma Ramos cells to ATO synergistically.
In other words, CuB enhanced the drug effects in the inhibition of lymphoma, particularly in resistance to Burkitt's lymphoma Ramos cells.
The results were attributed to the bioactive compound that blocks the activation of protein STAT3 associated with cancer cell proliferation and modulates the expression of proteins involved in pro and anti-apoptosis.
Interestingly, the combination of CuB and ATO kills cancer cells without causing harm to normal cell lines.
In the nude murine lymphoma model, the synergistic effect of the combination of CuB and ATO was once again confirmed by exhibiting significant apoptosis induction and tumor growth inhibition.
Dr. Ding X, the lead scientist said, "CuB synergistically enhances the apoptosis-inducing effect of ATO by inhibiting STAT3 phosphorylation in Ramos cells".
Taken together, cucumber combined with primary medicine may be used for the treatment of lymphoma, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells.
Ding X1,2, Chi J1,2, Yang X1,2, Hao J1,2, Liu C1,2, Zhu C1,2, Wang X1,2, Liu X1,2, Niu Y1,2, Ji W3, Chen D4, Wu X. (PubMed)
(2) Hereditary Lymphedema: Evidence for Linkage and Genetic Heterogeneity by Robert E. Ferrell Kara L. Levinson Judith H. Esman Mark A. KimakElizabeth C. Lawrence M. Michael Barmada David N. Finegold. (Oxford Academic)
#Phytochemical #Betacyanins Show a Significant Effect on Chain-Terminating Antioxidants, Researchers Find
Kyle J. Norton
Antioxidants are stable molecules produced by the liver or from the intake of diet sources, including foods and supplementation.
The function of antioxidants is to protect the body against oxidation induced by free radicals.
Free radicals are a normal byproduct of oxygen metabolism. Certain environmental and behavioral factors such as exposure to radiation and toxic chemicals and smoking can dramatically increase the number of free radicals in the body.
Free radicals have an unpaired electron on the outer ring. Therefore, in order to maintain stable, free radicals must donate or intercept an electron from other atoms, causing the domino reaction that can not be stopped until all single electrons are paired or inhibited by antioxidants.
Oxidative stress is a result of the imbalanced ratio of the levels of free radicals compared to antioxidants.
In other words, if the antioxidant enzymes no longer can perform the function to balance the free radicals in the body, oxidative stress occurs.
Epidemiologically, oxidative stress has been found to cause protein, lipid, and alternation of cellular DNA, leading to the incidence of chronic illness and cancers.
Dr. V. Hajhashemi, the lead scientist in the elevation of the effects of antioxidants for disease prevention wrote, "Free radicals are produced continuously in the cells as part of normal cellular function, however, excess production might play a role in pathophysiology of many disease conditions, including cancer, Alzheimer's disease, atherosclerosis and some of the drug-induced toxicity".
And, " Many basic research studies and observational epidemiologic studies in humans suggest that antioxidants can prevent oxidative damage".
In other words, by maintaining the healthy ratio of antioxidants and free radicals, diseases associated with oxidative stress can be preventable.
Some researchers suggested, that maintaining a balanced ratio of free radicals and antioxidants is the best way for good health.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the treatment of oxidative stress, researchers examined the betacyanins phenol antioxidants activity against peroxyl radicals generated from the azo-initiated oxidation of methyl linoleate in methanol and of a heterogeneous aqueous/soybean phosphatidylcholine liposomal system
In major compound betanin, researchers found that the phytochemical, a weak retarder in methanol is an effective chain-breaking antioxidant in the liposomal model.
In other words, kinetic solvent activity and partition in lipid bilayers may affect betanin antioxidant properties.
Betanidin, another bioactive compound shows a significant effect on chain-terminating antioxidants in both models.
In ROS activity, betanidin demonstrated a stronger radical-scavenging activity compared to betanin, in terms of both radical-scavenging rates constant and stoichiometric factor.
The results suggest that betacyanins exert significant anti-ROS expression by blocking the initiation and progression and induce-termination of a free radical chain reaction through the bioactive compound betanin and betanidin.
Based on the finding, researchers said, " Either betanin or betanidin incorporated in liposomes with alpha-tocopherol had additive effects, supporting the partition of the pigments in the bilayer and lipoperoxyl radical reduction".
Taken together, betacyanins may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes by Tesoriere L1, Allegra M, Gentile C, Livrea MA. (PubMed)
(2) Effect of solvent type and ratio on betacyanins and antioxidant activity of extracts from Hylocereus polyrhizus flesh and peel by supercritical fluid extraction and solvent extraction by Fathordoobady F1, Mirhosseini H1, Selamat J2, Manap MY. (PubMed)
(3) Are antioxidants helpful for disease prevention? by V. Hajhashemi,1,* G. Vaseghi,1 M. Pourfarzam,2 and A. Abdollahi. (PMC)
Antioxidants are stable molecules produced by the liver or from the intake of diet sources, including foods and supplementation.
The function of antioxidants is to protect the body against oxidation induced by free radicals.
Free radicals are a normal byproduct of oxygen metabolism. Certain environmental and behavioral factors such as exposure to radiation and toxic chemicals and smoking can dramatically increase the number of free radicals in the body.
Free radicals have an unpaired electron on the outer ring. Therefore, in order to maintain stable, free radicals must donate or intercept an electron from other atoms, causing the domino reaction that can not be stopped until all single electrons are paired or inhibited by antioxidants.
Oxidative stress is a result of the imbalanced ratio of the levels of free radicals compared to antioxidants.
In other words, if the antioxidant enzymes no longer can perform the function to balance the free radicals in the body, oxidative stress occurs.
Epidemiologically, oxidative stress has been found to cause protein, lipid, and alternation of cellular DNA, leading to the incidence of chronic illness and cancers.
Dr. V. Hajhashemi, the lead scientist in the elevation of the effects of antioxidants for disease prevention wrote, "Free radicals are produced continuously in the cells as part of normal cellular function, however, excess production might play a role in pathophysiology of many disease conditions, including cancer, Alzheimer's disease, atherosclerosis and some of the drug-induced toxicity".
And, " Many basic research studies and observational epidemiologic studies in humans suggest that antioxidants can prevent oxidative damage".
In other words, by maintaining the healthy ratio of antioxidants and free radicals, diseases associated with oxidative stress can be preventable.
Some researchers suggested, that maintaining a balanced ratio of free radicals and antioxidants is the best way for good health.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the treatment of oxidative stress, researchers examined the betacyanins phenol antioxidants activity against peroxyl radicals generated from the azo-initiated oxidation of methyl linoleate in methanol and of a heterogeneous aqueous/soybean phosphatidylcholine liposomal system
In major compound betanin, researchers found that the phytochemical, a weak retarder in methanol is an effective chain-breaking antioxidant in the liposomal model.
In other words, kinetic solvent activity and partition in lipid bilayers may affect betanin antioxidant properties.
Betanidin, another bioactive compound shows a significant effect on chain-terminating antioxidants in both models.
In ROS activity, betanidin demonstrated a stronger radical-scavenging activity compared to betanin, in terms of both radical-scavenging rates constant and stoichiometric factor.
The results suggest that betacyanins exert significant anti-ROS expression by blocking the initiation and progression and induce-termination of a free radical chain reaction through the bioactive compound betanin and betanidin.
Based on the finding, researchers said, " Either betanin or betanidin incorporated in liposomes with alpha-tocopherol had additive effects, supporting the partition of the pigments in the bilayer and lipoperoxyl radical reduction".
Taken together, betacyanins may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes by Tesoriere L1, Allegra M, Gentile C, Livrea MA. (PubMed)
(2) Effect of solvent type and ratio on betacyanins and antioxidant activity of extracts from Hylocereus polyrhizus flesh and peel by supercritical fluid extraction and solvent extraction by Fathordoobady F1, Mirhosseini H1, Selamat J2, Manap MY. (PubMed)
(3) Are antioxidants helpful for disease prevention? by V. Hajhashemi,1,* G. Vaseghi,1 M. Pourfarzam,2 and A. Abdollahi. (PMC)
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