Kyle J. Norton
Infection is a condition caused by a harmful microbial invasion of the body's tissues
Most cases of bacterial infection are treated with antibiotics. However, bacteria are very adaptable, and overuse of antibiotics has been found to make them resistant to antibiotics.
Out of trillions of strains of bacteria in the world, only a few cause diseases in humans. Believe it or not, our gut contains trillion microorganisms, most of which are bacteria.
The most common symptoms of bacterial infection are redness and heat, swelling, fever, and pain at the site of infection.
In severe cases, the patient may also experience symptoms of swollen lymph glands.
Most cases of bacterial infection are treated successfully if the types of bacteria that cause the infection are identified.
There are many risk factors associated with the onset of bacterial infection, people with severe chronic disease may increase the prevalence of bacterial infection, particularly in those with cirrhosis.
Dr. Deschênes M, the lead scientist at the Université de Montréal wrote, "Bacterial infection is a frequent and severe complication of cirrhosis. Cirrhotic patients admitted for gastrointestinal bleeding are at high risk of such a complication and have been targeted in trials of antibiotic prophylaxis".
And, " patients with severe cirrhosis who are admitted for gastrointestinal bleeding have a higher risk of developing a bacterial infection during their hospitalization than other cirrhotic patients".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of bacterial infection, researchers examined the effect of cranberry antibacterial activity against uropathogenic strains of Escherichia coli (UPEC).
According to the tested analysis, the whole extract showed a powerful antibacterial activity against UPEC compared to the selected fractions that presented a different behavior.
Myricetin and quercitrin demonstrated the highest decrease in E. coli biofilm formation compared with the control and other fractions.
However, other chemical constituents such as dihydro ferulic acid glucuronide, procyanidin A dimer, quercetin glucoside, myricetin, and prodelphinidin B led to a significant decrease of the surface hydrophobicity compared with the control.
In other words, all fractions in the cranberry extract worked synergistically to protect the host against the infection caused by E. coli
Based on the results, researchers said, "Apart from proanthocyanidins, other compounds, mainly flavonoids, can act against E. coli biofilm formation and also modify UPEC surface hydrophobicity in vitro."
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of bacterial infection, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antibacterial activity of isolated phenolic compounds from cranberry (Vaccinium macrocarpon) against Escherichia coli by Rodríguez-Pérez C1, Quirantes-Piné R2, Uberos J3, Jiménez-Sánchez C1, Peña A4, Segura-Carretero A. (PubMed)
(2) In Vivo Consumption of Cranberry Exerts ex Vivo Antiadhesive Activity against FimH-Dominated Uropathogenic Escherichia coli: A Combined in Vivo, Ex Vivo, and In Vitro Study of an Extract from Vaccinium macrocarpon by Rafsanjany N1, Senker J1, Brandt S1, Dobrindt U2, Hensel A. (PubMed)
(3) Risk factors for the development of bacterial infections in hospitalized patients with cirrhosis by Deschênes M1, Villeneuve JP. (PubMed)
Sunday, 3 September 2023
#Phytochemical #Lycopene Inhibits Vascular #Oxidativestress and Inflammation that Cause Dyslipidemia, Researchers Show
Kyle J. Norton
Antioxidants are stable atoms that inhibit the oxidation caused by reactive oxygen species. Antioxidants also play a critical role in the prevention of the oxidative stress induced by a chain of reactions as a result of over-expression of free radicals that can only be stopped with the expression of antioxidants produced by the host or from dietary sources.
More precisely, oxidative stress is caused by the imbalance of the ratio of free radicals and antioxidants.
Epidemiologically, over time, oxidative stress induces damage to protein, lipid, and cell DNA that leads to the incidences of chronic disease, including heart disease, RA, and cancers.
In cancer, antioxidants are molecules that process the capability to protect healthy cells against oxidative stress-induced DNA alternation.
In cardiovascular disease, antioxidants reduce the fragility and “permeability” in capillaries and prevent the clotting up of arteries due to oxidation.
In RA, antioxidant inhibits the rheumatoid joint fluid containing significant amounts of hydroxyl radical.
The overexpression of free radicals is bad. However, free radicals generated from cell metabolism may play a critical role in the synthesis of the energy of essential molecules and boosting the immune system. According to the free radical theory, over time, the damage inflicted by reactive oxygen species (ROS), can also induce skin aging.
In a healthy individual, antioxidant enzymes produced by the body are more than enough to accounter the expression of free radicals that occur in our body every day.
However, in people with a weakened immune system such as the elderly, the intake of dietary antioxidants such as supplements or fruits rich with antioxidants may be the only option to improve levels of antioxidants in the body.
Dyslipidemia is a condition with an abnormally high amount of lipids (e.g. triglycerides, cholesterol, and/or fat phospholipids) in the blood.
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
In finding a potential ingredient for the prevention and treatment of diseases associated with oxidative stress, researchers examined the effects of lycopene on vascular oxidative stress and inflammation in a young healthy subject.
The study included blood collection of 18 men and 9 women with restriction of lycopene-containing foods for 1-wk (LYr), after a fasting state, and 3 hours after an HFm and a low-fat meal (LFm).
Compared to the blood sample collected on pre-and post-meals following 1-wk of 80 mg/day lycopene supplementation (LYs) under continued dietary LYr in the fasting state, researchers found that
* LYs compared with LYr not only evoked a >2-fold increase in plasma lycopene but also increased plasma beta-carotene and alpha-tocopherol.
* However, LYs did not affect plasma nitrate/nitrite, a biomarker of nitric oxide, malondialdehyde, a biomarker of lipid oxidative stress, vascular- and intercellular-adhesion molecules or C-reactive protein, the biomarkers of inflammation.
In other words, the HFm-induced dyslipidemic state was inhibited by LYr or LYs but did not affect the plasma malondialdehyde, C-reactive protein, or adhesion molecules.
The results suggested that 1-wk of LYs increased plasma lycopene, beta-carotene, and alpha-tocopherol do not have an effect on the plasma lipid-soluble antioxidant pool, biomarkers of vascular oxidative stress and inflammation in the fasted state as well as during dyslipidemia induced by an HFm in young healthy subjects.
In other words, plasma lycopene consumption inhibits dyslipidemia but does not affect the changes of parameters induced by an HFm in young healthy subjects in the short term.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The role of the antioxidants lycopene and vitamin E in the prevention of halothane-induced hepatotoxicity by Beştaş A1, Kahramanoglu M, Erhan OL, Bolat E, Ozercan I, Gürsu F, Gülcü F. (PubMed)
(2) Effect of short-term lycopene supplementation and postprandial dyslipidemia on plasma antioxidants and biomarkers of endothelial health in young, healthy individuals by Denniss SG1, Haffner TD, Kroetsch JT, Davidson SR, Rush JW, Hughson RL. (PubMed)
Antioxidants are stable atoms that inhibit the oxidation caused by reactive oxygen species. Antioxidants also play a critical role in the prevention of the oxidative stress induced by a chain of reactions as a result of over-expression of free radicals that can only be stopped with the expression of antioxidants produced by the host or from dietary sources.
More precisely, oxidative stress is caused by the imbalance of the ratio of free radicals and antioxidants.
Epidemiologically, over time, oxidative stress induces damage to protein, lipid, and cell DNA that leads to the incidences of chronic disease, including heart disease, RA, and cancers.
In cancer, antioxidants are molecules that process the capability to protect healthy cells against oxidative stress-induced DNA alternation.
In cardiovascular disease, antioxidants reduce the fragility and “permeability” in capillaries and prevent the clotting up of arteries due to oxidation.
In RA, antioxidant inhibits the rheumatoid joint fluid containing significant amounts of hydroxyl radical.
The overexpression of free radicals is bad. However, free radicals generated from cell metabolism may play a critical role in the synthesis of the energy of essential molecules and boosting the immune system. According to the free radical theory, over time, the damage inflicted by reactive oxygen species (ROS), can also induce skin aging.
In a healthy individual, antioxidant enzymes produced by the body are more than enough to accounter the expression of free radicals that occur in our body every day.
However, in people with a weakened immune system such as the elderly, the intake of dietary antioxidants such as supplements or fruits rich with antioxidants may be the only option to improve levels of antioxidants in the body.
Dyslipidemia is a condition with an abnormally high amount of lipids (e.g. triglycerides, cholesterol, and/or fat phospholipids) in the blood.
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
In finding a potential ingredient for the prevention and treatment of diseases associated with oxidative stress, researchers examined the effects of lycopene on vascular oxidative stress and inflammation in a young healthy subject.
The study included blood collection of 18 men and 9 women with restriction of lycopene-containing foods for 1-wk (LYr), after a fasting state, and 3 hours after an HFm and a low-fat meal (LFm).
Compared to the blood sample collected on pre-and post-meals following 1-wk of 80 mg/day lycopene supplementation (LYs) under continued dietary LYr in the fasting state, researchers found that
* LYs compared with LYr not only evoked a >2-fold increase in plasma lycopene but also increased plasma beta-carotene and alpha-tocopherol.
* However, LYs did not affect plasma nitrate/nitrite, a biomarker of nitric oxide, malondialdehyde, a biomarker of lipid oxidative stress, vascular- and intercellular-adhesion molecules or C-reactive protein, the biomarkers of inflammation.
In other words, the HFm-induced dyslipidemic state was inhibited by LYr or LYs but did not affect the plasma malondialdehyde, C-reactive protein, or adhesion molecules.
The results suggested that 1-wk of LYs increased plasma lycopene, beta-carotene, and alpha-tocopherol do not have an effect on the plasma lipid-soluble antioxidant pool, biomarkers of vascular oxidative stress and inflammation in the fasted state as well as during dyslipidemia induced by an HFm in young healthy subjects.
In other words, plasma lycopene consumption inhibits dyslipidemia but does not affect the changes of parameters induced by an HFm in young healthy subjects in the short term.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The role of the antioxidants lycopene and vitamin E in the prevention of halothane-induced hepatotoxicity by Beştaş A1, Kahramanoglu M, Erhan OL, Bolat E, Ozercan I, Gürsu F, Gülcü F. (PubMed)
(2) Effect of short-term lycopene supplementation and postprandial dyslipidemia on plasma antioxidants and biomarkers of endothelial health in young, healthy individuals by Denniss SG1, Haffner TD, Kroetsch JT, Davidson SR, Rush JW, Hughson RL. (PubMed)
#Ginger Inhibits Markers Associated with the Risk of #MetabolicSyndrome and Type 2 Diabetes, Scientists Say
Kyle J. Norton
Ginger may have a potential and profound effect in regulating the expression of metabolic syndrome, some scientists suggested.
Metabolic syndrome is a cluster of conditions associated with the onset of cardiovascular disease and diabetes, including fat around the waist, elevated blood pressure, high triglycerides, elevated blood sugar, and low HDL cholesterol.
Researchers suggested that people who have 3 of 5 above conditions are at substantial risk of heart disease, stroke, and type 2 diabetes.
There is no single cause of the metabolic syndrome. some conditions epidemiologically are associated with overweight or obesity, insulin resistance, inactive lifestyle, and poor diet.
According to the statistics, In the US, approximately, over 23 percent of adults have metabolic syndrome, and many of them do not know they have it.
In fact, metabolic syndrome can be reversed through a healthy lifestyle choice, accompanied by weight loss.
Dr. Christos Pitsavos, the cardio team at the University of Athens and Society for Biomedical Diabetes Research, wrote, "Several epidemiologic studies and some clinical trials, it has been suggested that people with the metabolic syndrome may benefit from intensive lifestyle modifications including dietary changes and adopting a physically more active lifestyle."
"During the last decades increasing scientific evidence has emerged that protective health effects can be obtained from diets that are rich in fruits, vegetables, legumes, and whole grains, and which include fish, nuts, and low-fat dairy products".
These results clearly stated that by changing the poor diet pattern to a healthy one accompanied by moderate exercise, metabolic syndrome can be reserved.
Furthermore, a healthy lifestyle in patients with metabolic syndrome also greatly improves the reduction of body weight.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural ingredient or whole food for the treatment of metabolic syndrome, researchers assess the effects of ginger (Zingiber officinale Roscoe) on type 2 diabetes mellitus (T2DM) and/or components of the metabolic syndrome (MetS) by searching the database of medical literature.
10 studies met the inclusion criteria with a total of 490 individuals included in the review.
Ginger showed a significant beneficial effect on glucose control and insulin sensitivity.
Ginger significantly reduced fasting blood glucose in T2DM patients (-21.24; 95% CI: -33.21, -9.26; P < 0.001) and three-month average plasma glucose concentration.
Furthermore, ginger also displayed significant effects of improvement of lipid profile.
Dr. Zhu J, the lead scientist said, in the final report "Based on the negligible side effects and obvious ameliorative effects on glucose control, insulin sensitivity, and lipid profile, ginger may be a promising adjuvant therapy for T2DM and MetS".
Moreover, in order to gain more evidence of ginger's anti-metabolic syndrome effect, a study to determine the individual and concomitant effect of 6-week water-based exercise and oral ginger supplement on markers that are related to metabolic syndrome and systemic inflammation in obese women with breast neoplasms was conducted the University of Mazandaran.
40 women diagnosed with breast neoplasms were randomly assigned into four groups; placebo, exercise training, ginger supplement, and exercise training+ ginger supplement groups.
Participants in the ginger supplement group and the exercise training+ ginger supplement group have orally received 4 capsules, 7 days a week and for 6 weeks.
During the experiment, the ginger supplementation and the water-based exercise have resulted in a reduction of hs-CRP, IL-10 (inflammation), insulin, glucose, insulin resistance, low-density lipoprotein (LDL), triglyceride (TG); but an increase in high-density lipoprotein (HDL) and ratio HDL/LDL.
These results strongly suggested that ginger supplement plus exercise demonstrates a significant effect in reducing the fasting glucose, insulin resistance, inflammation, and lipid profile and balancing the ratio of high and low-density lipoproteins.
In other words, the water-based exercise and ginger supplement group significantly showed a larger positive effect on all outcomes, compared to the water-based exercise or ginger supplement alone groups.
The findings suggested that obese breast neoplasm survivors' metabolic syndrome and elevated inflammation were totally inhibited by the application of ginger supplement plus exercise training.
Taken together, ginger, the pungent spice can be considered a functional food for the prevention and treatment of metabolic syndrome accompanied by moderate exercise without inducing any adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Effects of Ginger (Zingiber officinale Roscoe) on Type 2 Diabetes Mellitus and Components of the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Zhu J1, Chen H1, Song Z1, Wang X1, Sun Z2. (PubMed)
(2) Individually and Combined Water-Based Exercise With Ginger Supplement, on Systemic Inflammation and Metabolic Syndrome Indices, Among the Obese Women With Breast Neoplasms by Karimi N1, Dabidi Roshan V1, Fathi Bayatiyani Z1. (PubMed)
(3) Diet, Exercise and Metabolic Syndrome by Christos Pitsavos,1 Demosthenes Panagiotakos,2 Michael Weinem,3 and Christodoulos Stefanadis. (PMC)
Ginger may have a potential and profound effect in regulating the expression of metabolic syndrome, some scientists suggested.
Metabolic syndrome is a cluster of conditions associated with the onset of cardiovascular disease and diabetes, including fat around the waist, elevated blood pressure, high triglycerides, elevated blood sugar, and low HDL cholesterol.
Researchers suggested that people who have 3 of 5 above conditions are at substantial risk of heart disease, stroke, and type 2 diabetes.
There is no single cause of the metabolic syndrome. some conditions epidemiologically are associated with overweight or obesity, insulin resistance, inactive lifestyle, and poor diet.
According to the statistics, In the US, approximately, over 23 percent of adults have metabolic syndrome, and many of them do not know they have it.
In fact, metabolic syndrome can be reversed through a healthy lifestyle choice, accompanied by weight loss.
Dr. Christos Pitsavos, the cardio team at the University of Athens and Society for Biomedical Diabetes Research, wrote, "Several epidemiologic studies and some clinical trials, it has been suggested that people with the metabolic syndrome may benefit from intensive lifestyle modifications including dietary changes and adopting a physically more active lifestyle."
"During the last decades increasing scientific evidence has emerged that protective health effects can be obtained from diets that are rich in fruits, vegetables, legumes, and whole grains, and which include fish, nuts, and low-fat dairy products".
These results clearly stated that by changing the poor diet pattern to a healthy one accompanied by moderate exercise, metabolic syndrome can be reserved.
Furthermore, a healthy lifestyle in patients with metabolic syndrome also greatly improves the reduction of body weight.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural ingredient or whole food for the treatment of metabolic syndrome, researchers assess the effects of ginger (Zingiber officinale Roscoe) on type 2 diabetes mellitus (T2DM) and/or components of the metabolic syndrome (MetS) by searching the database of medical literature.
10 studies met the inclusion criteria with a total of 490 individuals included in the review.
Ginger showed a significant beneficial effect on glucose control and insulin sensitivity.
Ginger significantly reduced fasting blood glucose in T2DM patients (-21.24; 95% CI: -33.21, -9.26; P < 0.001) and three-month average plasma glucose concentration.
Furthermore, ginger also displayed significant effects of improvement of lipid profile.
Dr. Zhu J, the lead scientist said, in the final report "Based on the negligible side effects and obvious ameliorative effects on glucose control, insulin sensitivity, and lipid profile, ginger may be a promising adjuvant therapy for T2DM and MetS".
Moreover, in order to gain more evidence of ginger's anti-metabolic syndrome effect, a study to determine the individual and concomitant effect of 6-week water-based exercise and oral ginger supplement on markers that are related to metabolic syndrome and systemic inflammation in obese women with breast neoplasms was conducted the University of Mazandaran.
40 women diagnosed with breast neoplasms were randomly assigned into four groups; placebo, exercise training, ginger supplement, and exercise training+ ginger supplement groups.
Participants in the ginger supplement group and the exercise training+ ginger supplement group have orally received 4 capsules, 7 days a week and for 6 weeks.
During the experiment, the ginger supplementation and the water-based exercise have resulted in a reduction of hs-CRP, IL-10 (inflammation), insulin, glucose, insulin resistance, low-density lipoprotein (LDL), triglyceride (TG); but an increase in high-density lipoprotein (HDL) and ratio HDL/LDL.
These results strongly suggested that ginger supplement plus exercise demonstrates a significant effect in reducing the fasting glucose, insulin resistance, inflammation, and lipid profile and balancing the ratio of high and low-density lipoproteins.
In other words, the water-based exercise and ginger supplement group significantly showed a larger positive effect on all outcomes, compared to the water-based exercise or ginger supplement alone groups.
The findings suggested that obese breast neoplasm survivors' metabolic syndrome and elevated inflammation were totally inhibited by the application of ginger supplement plus exercise training.
Taken together, ginger, the pungent spice can be considered a functional food for the prevention and treatment of metabolic syndrome accompanied by moderate exercise without inducing any adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Effects of Ginger (Zingiber officinale Roscoe) on Type 2 Diabetes Mellitus and Components of the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Zhu J1, Chen H1, Song Z1, Wang X1, Sun Z2. (PubMed)
(2) Individually and Combined Water-Based Exercise With Ginger Supplement, on Systemic Inflammation and Metabolic Syndrome Indices, Among the Obese Women With Breast Neoplasms by Karimi N1, Dabidi Roshan V1, Fathi Bayatiyani Z1. (PubMed)
(3) Diet, Exercise and Metabolic Syndrome by Christos Pitsavos,1 Demosthenes Panagiotakos,2 Michael Weinem,3 and Christodoulos Stefanadis. (PMC)
Phytochemical #Tocopherols' #HealthBenefits, According to Studies
Kyle J. Norton
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
1. Antioxidative, anti-inflammatory, and anticarcinogenic activities
In the examination of the inhibition of inflammation as well as of cancer formation and growth in the lung and colon in animal models., using a-tocopherol mixture that is rich in gamma-T (gamma-TmT, which contains 57%gamma-T), found that when given in the diet at 0.3%, gamma-TmT inhibited chemically induced lung tumorigenesis in the A/J mice as well as the growth of human lung cancer cell H1299 xenograft tumors. gamma-TmT also decreased the levels of 8-hydroxydeoxyguanosine, gamma-H2AX, and nitrotyrosine in tumors. More evident anti-inflammatory and cancer preventive activities of dietary gamma-TmT were demonstrated in mice treated with azoxymethane and dextran sulfate sodium. These results demonstrate the antioxidative, anti-inflammatory, and anticarcinogenic activities of tocopherols, according to "Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols" by Yang CS, Lu G, Ju J, Li GX.(1)
2. Cancer prevention
The study of the cancer-preventive activities of tocopherols and tocotrienols, indicated that a gamma-tocopherol-rich mixture of tocopherols inhibits colon, prostate, mammary, and lung tumorigenesis in animal models, suggesting that this mixture may have a high potential for applications in the prevention of human cancer. In this review, we discuss biochemical properties of tocopherols, results of possible cancer-preventive effects in humans and animal models, and possible mechanisms involved in the inhibition of carcinogenesis. Based on this information, we propose that a gamma-tocopherol-rich mixture of tocopherols is a very promising cancer-preventive agent and warrants extensive future research, according to "Cancer-preventive activities of tocopherols and tocotrienols" by Ju J, Picinich SC, Yang Z, Zhao Y, Suh N, Kong AN, Yang CS.(2)
3. Bone formation
In the investigation of the antioxidant and anti-inflammatory properties of Alpha- and gamma-tocopherol, the two predominant isomers of vitamin E and their effects on bone metabolism, found that gamma-tocopherol may uncouple bone turnover, resulting in more bone formation than resorption. Vitamin E supplements in the form of alpha-tocopherol suppress serum gamma-tocopherol levels and may have negative effects on bone formation. Further research is needed to investigate the potential anabolic effect of gamma-tocopherol from food sources on bone, according to "Effects of vitamin E on bone turnover markers among US postmenopausal women" by Hamidi MS, Corey PN, Cheung AM.(3)
4. Liver fibrosis
In the study of Antiproliferative and proapoptotic effects of tocopherol and tocol on activated hepatic stellate cells, found that significant cell detachment was also observed in δ-tocopherol- and tocol-treated HSCs. Decreased protein expressions of α-smooth muscle actin and β1 integrin were observed in a dose-dependent manner. These results indicate that δ-tocopherol and tocol induce anoikis in activated HSCs, according to "Antiproliferative and proapoptotic effects of tocopherol and tocol on activated hepatic stellate cells" by Yamaguchi N, Mezaki Y, Miura M, Imai K, Morii M, Hebiguchi T, Yoshikawa K.(4)
5. Antioxidant and Antidiabetic Activities
In the determination of the antioxidant and antidiabetic activities of proximate composition, amino acids, fatty acids, tocopherols, sterols, glucosinolate and phenolic content in extracts, found that all examined extracts were prominently rich in phenolics and glucosinates, and they showed potent antidiabetic and antihemolytic activity. The present study could be helpful in developing medicinal preparations for the treatment of diabetes and related symptoms, according to "Compositional Studies: Antioxidant and Antidiabetic Activities of Capparis decidua (Forsk.) Edgew" by Zia-Ul-Haq M, Cavar S, Qayum M, Imran I, de Feo V.(5)
6. Breast cancer
in the investigation of the breast cancer effect of vitamin E, consisting of eight different variants: α-, β-, γ-, and δ-tocopherols (saturated phytyl tail) and α-, β-, γ-, and δ-tocotrienols (unsaturated phytyl tail), indicated that γ-tocopherol, and more recently δ-tocopherol, have shown greater ability to reduce inflammation, cell proliferation, and tumor burden. Recent results have shown that γ-enriched mixed tocopherols inhibit the development of mammary hyperplasia and tumorigenesis in animal models, according to "Chemopreventive Activity of Vitamin E in Breast Cancer: A Focus on γ- and δ-Tocopherol" by Smolarek AK, Suh N.(6)
7. Colon cancer
In the investigation of the effects of both alpha and gamma-tocopherol on the expression of PPARgamma mRNA and protein in SW 480 colon cancer cell lines and measurement of the intracellular concentrations of vitamin E in SW 480 colon cancer cell lines, found that both alpha and gamma-tocopherol can upregulate the expression of PPARgamma which is considered an important molecular target for colon cancer chemoprevention, according to "Gamma (gamma) tocopherol upregulates peroxisome proliferator-activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines" by Campbell SE, Stone WL, Whaley SG, Qui M, Krishnan K.(7)
8. Antioxidant defense
in the study of salmon, a rich source of marine n-3 fatty acids, which may increase oxidative stress and, in turn, and its affect the antioxidant defense system in blood plasma and erythrocytes of pregnant women, found that besides, a concomitant increase in selenium and glutathione concentration, as well as glutathione peroxidase and reductase activities, were detected as the pregnancy progressed. However, tocopherols, retinol, β-carotene, and coenzyme Q(10) decreased in late pregnancy. Collectively, our findings lead to the hypothesis that increased farmed salmon intake may increase antioxidant defenses during pregnancy, according to "Does Consumption of Two Portions of Salmon Per Week Enhance the Antioxidant Defense System in Pregnant Women?" by García-Rodríguez CE, D Mesa M, Olza J, Vlachava M, Kremmyda LS, Diaper ND, Noakes PS, Miles EA, Ramírez-Tortosa MC, Liaset B, Frøyland L, Rossary A, Farges MC, Vasson MP, Aguilera CM, Helmersson-Karlqvist J, Godfrey KM, Calder PC, Basu S, Gil A.(8)
9. The antioxidant and anti-inflammatory activities
In the investigation of the antioxidant and anti-inflammatory actions of tocopherols in mice and determination of whether the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is involved in these activities, indicated that the antioxidant and anti-inflammatory activities of γ-TmT in the colon are mostly due to the direct action of tocopherols in trapping reactive oxygen and nitrogen species, independent of the antioxidant enzymes and anti-inflammatory proteins that are regulated by Nrf2; however, Nrf2 knockout appears to affect the serum levels of tocopherol metabolites, according to "The antioxidant and anti-inflammatory activities of tocopherols are independent of Nrf2 in mice" by Li G, Lee MJ, Liu AB, Yang Z, Lin Y, Shih WJ, Yang CS.(9)
10. Cognitive effects
In the examination of the relation of all plasma vitamin E forms and markers of vitamin E damage (α-tocopheryl quinone, 5-nitro-γ-tocopherol) to mild cognitive impairment (MCI) and Alzheimer's disease (AD). Within the AddNeuroMed-Project, plasma tocopherols, tocotrienols, α-tocopheryl quinone, and 5-nitro-γ-tocopherol were assessed in 168 AD cases, 166 MCI, and 187 cognitively normal (CN) people, found that compared with cognitively normal subjects, AD and MCI had lower levels of total tocopherols, total tocotrienols, and total vitamin E. In multivariable-polytomous-logistic regression analysis, both MCI and AD cases had 85% lower odds to be in the highest tertile of total tocopherols and total vitamin E, and they were, respectively, 92% and 94% less likely to be in the highest tertile of total tocotrienols than the lowest tertile. Further, both disorders were associated with increased vitamin E damage. Low plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD, according to "Tocopherols and tocotrienols plasma levels are associated with cognitive impairment" by Mangialasche F, Xu W, Kivipelto M, Costanzi E, Ercolani S, Pigliautile M, Cecchetti R, Baglioni M, Simmons A, Soininen H, Tsolaki M, Kloszewska I, Vellas B, Lovestone S, Mecocci P; AddNeuroMed Consortium. (10)
11. Renal effects
In the examination of whether γ-tocotrienol (GT3) protects against mitochondrial dysfunction and renal proximal tubular cell (RPTC) injury caused by oxidants, showed that report demonstrating the protective effects of GT3 against RPTC injury by 1) decreasing the production of ROS, 2) improving mitochondrial respiration, coupling, ΔΨ(m), and F₀F₁-ATPase function, 3) maintaining ATP levels, and 4) preventing RPTC lysis. Our data suggest that GT3 is superior to AT in protecting RPTCs against oxidant injury and may prove therapeutically valuable for preventing renal injury associated with oxidative stress, according to "γ-Tocotrienol protects against mitochondrial dysfunction and renal cell death" by Nowak G, Bakajsova D, Hayes C, Hauer-Jensen M, Compadre CM.(11)
12. Etc.
Back to Popular Herbs http://kylejnorton.blogspot.ca/p/popular-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20716280
(2) http://www.ncbi.nlm.nih.gov/pubmed/19748925
(3) http://www.ncbi.nlm.nih.gov/pubmed/22308007
(4) http://www.ncbi.nlm.nih.gov/pubmed/22293208
(5) http://www.mdpi.com/1422-0067/12/12/8846/
(6) http://www.ncbi.nlm.nih.gov/pubmed/22254089
(7) http://www.ncbi.nlm.nih.gov/pubmed/14521714
(8) http://www.ncbi.nlm.nih.gov/pubmed/22229304
(9) http://www.ncbi.nlm.nih.gov/pubmed/22226829
(10) http://www.ncbi.nlm.nih.gov/pubmed/22192241
(11) http://www.ncbi.nlm.nih.gov/pubmed/22040679
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
1. Antioxidative, anti-inflammatory, and anticarcinogenic activities
In the examination of the inhibition of inflammation as well as of cancer formation and growth in the lung and colon in animal models., using a-tocopherol mixture that is rich in gamma-T (gamma-TmT, which contains 57%gamma-T), found that when given in the diet at 0.3%, gamma-TmT inhibited chemically induced lung tumorigenesis in the A/J mice as well as the growth of human lung cancer cell H1299 xenograft tumors. gamma-TmT also decreased the levels of 8-hydroxydeoxyguanosine, gamma-H2AX, and nitrotyrosine in tumors. More evident anti-inflammatory and cancer preventive activities of dietary gamma-TmT were demonstrated in mice treated with azoxymethane and dextran sulfate sodium. These results demonstrate the antioxidative, anti-inflammatory, and anticarcinogenic activities of tocopherols, according to "Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols" by Yang CS, Lu G, Ju J, Li GX.(1)
2. Cancer prevention
The study of the cancer-preventive activities of tocopherols and tocotrienols, indicated that a gamma-tocopherol-rich mixture of tocopherols inhibits colon, prostate, mammary, and lung tumorigenesis in animal models, suggesting that this mixture may have a high potential for applications in the prevention of human cancer. In this review, we discuss biochemical properties of tocopherols, results of possible cancer-preventive effects in humans and animal models, and possible mechanisms involved in the inhibition of carcinogenesis. Based on this information, we propose that a gamma-tocopherol-rich mixture of tocopherols is a very promising cancer-preventive agent and warrants extensive future research, according to "Cancer-preventive activities of tocopherols and tocotrienols" by Ju J, Picinich SC, Yang Z, Zhao Y, Suh N, Kong AN, Yang CS.(2)
3. Bone formation
In the investigation of the antioxidant and anti-inflammatory properties of Alpha- and gamma-tocopherol, the two predominant isomers of vitamin E and their effects on bone metabolism, found that gamma-tocopherol may uncouple bone turnover, resulting in more bone formation than resorption. Vitamin E supplements in the form of alpha-tocopherol suppress serum gamma-tocopherol levels and may have negative effects on bone formation. Further research is needed to investigate the potential anabolic effect of gamma-tocopherol from food sources on bone, according to "Effects of vitamin E on bone turnover markers among US postmenopausal women" by Hamidi MS, Corey PN, Cheung AM.(3)
4. Liver fibrosis
In the study of Antiproliferative and proapoptotic effects of tocopherol and tocol on activated hepatic stellate cells, found that significant cell detachment was also observed in δ-tocopherol- and tocol-treated HSCs. Decreased protein expressions of α-smooth muscle actin and β1 integrin were observed in a dose-dependent manner. These results indicate that δ-tocopherol and tocol induce anoikis in activated HSCs, according to "Antiproliferative and proapoptotic effects of tocopherol and tocol on activated hepatic stellate cells" by Yamaguchi N, Mezaki Y, Miura M, Imai K, Morii M, Hebiguchi T, Yoshikawa K.(4)
5. Antioxidant and Antidiabetic Activities
In the determination of the antioxidant and antidiabetic activities of proximate composition, amino acids, fatty acids, tocopherols, sterols, glucosinolate and phenolic content in extracts, found that all examined extracts were prominently rich in phenolics and glucosinates, and they showed potent antidiabetic and antihemolytic activity. The present study could be helpful in developing medicinal preparations for the treatment of diabetes and related symptoms, according to "Compositional Studies: Antioxidant and Antidiabetic Activities of Capparis decidua (Forsk.) Edgew" by Zia-Ul-Haq M, Cavar S, Qayum M, Imran I, de Feo V.(5)
6. Breast cancer
in the investigation of the breast cancer effect of vitamin E, consisting of eight different variants: α-, β-, γ-, and δ-tocopherols (saturated phytyl tail) and α-, β-, γ-, and δ-tocotrienols (unsaturated phytyl tail), indicated that γ-tocopherol, and more recently δ-tocopherol, have shown greater ability to reduce inflammation, cell proliferation, and tumor burden. Recent results have shown that γ-enriched mixed tocopherols inhibit the development of mammary hyperplasia and tumorigenesis in animal models, according to "Chemopreventive Activity of Vitamin E in Breast Cancer: A Focus on γ- and δ-Tocopherol" by Smolarek AK, Suh N.(6)
7. Colon cancer
In the investigation of the effects of both alpha and gamma-tocopherol on the expression of PPARgamma mRNA and protein in SW 480 colon cancer cell lines and measurement of the intracellular concentrations of vitamin E in SW 480 colon cancer cell lines, found that both alpha and gamma-tocopherol can upregulate the expression of PPARgamma which is considered an important molecular target for colon cancer chemoprevention, according to "Gamma (gamma) tocopherol upregulates peroxisome proliferator-activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines" by Campbell SE, Stone WL, Whaley SG, Qui M, Krishnan K.(7)
8. Antioxidant defense
in the study of salmon, a rich source of marine n-3 fatty acids, which may increase oxidative stress and, in turn, and its affect the antioxidant defense system in blood plasma and erythrocytes of pregnant women, found that besides, a concomitant increase in selenium and glutathione concentration, as well as glutathione peroxidase and reductase activities, were detected as the pregnancy progressed. However, tocopherols, retinol, β-carotene, and coenzyme Q(10) decreased in late pregnancy. Collectively, our findings lead to the hypothesis that increased farmed salmon intake may increase antioxidant defenses during pregnancy, according to "Does Consumption of Two Portions of Salmon Per Week Enhance the Antioxidant Defense System in Pregnant Women?" by García-Rodríguez CE, D Mesa M, Olza J, Vlachava M, Kremmyda LS, Diaper ND, Noakes PS, Miles EA, Ramírez-Tortosa MC, Liaset B, Frøyland L, Rossary A, Farges MC, Vasson MP, Aguilera CM, Helmersson-Karlqvist J, Godfrey KM, Calder PC, Basu S, Gil A.(8)
9. The antioxidant and anti-inflammatory activities
In the investigation of the antioxidant and anti-inflammatory actions of tocopherols in mice and determination of whether the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is involved in these activities, indicated that the antioxidant and anti-inflammatory activities of γ-TmT in the colon are mostly due to the direct action of tocopherols in trapping reactive oxygen and nitrogen species, independent of the antioxidant enzymes and anti-inflammatory proteins that are regulated by Nrf2; however, Nrf2 knockout appears to affect the serum levels of tocopherol metabolites, according to "The antioxidant and anti-inflammatory activities of tocopherols are independent of Nrf2 in mice" by Li G, Lee MJ, Liu AB, Yang Z, Lin Y, Shih WJ, Yang CS.(9)
10. Cognitive effects
In the examination of the relation of all plasma vitamin E forms and markers of vitamin E damage (α-tocopheryl quinone, 5-nitro-γ-tocopherol) to mild cognitive impairment (MCI) and Alzheimer's disease (AD). Within the AddNeuroMed-Project, plasma tocopherols, tocotrienols, α-tocopheryl quinone, and 5-nitro-γ-tocopherol were assessed in 168 AD cases, 166 MCI, and 187 cognitively normal (CN) people, found that compared with cognitively normal subjects, AD and MCI had lower levels of total tocopherols, total tocotrienols, and total vitamin E. In multivariable-polytomous-logistic regression analysis, both MCI and AD cases had 85% lower odds to be in the highest tertile of total tocopherols and total vitamin E, and they were, respectively, 92% and 94% less likely to be in the highest tertile of total tocotrienols than the lowest tertile. Further, both disorders were associated with increased vitamin E damage. Low plasma tocopherols and tocotrienols levels are associated with increased odds of MCI and AD, according to "Tocopherols and tocotrienols plasma levels are associated with cognitive impairment" by Mangialasche F, Xu W, Kivipelto M, Costanzi E, Ercolani S, Pigliautile M, Cecchetti R, Baglioni M, Simmons A, Soininen H, Tsolaki M, Kloszewska I, Vellas B, Lovestone S, Mecocci P; AddNeuroMed Consortium. (10)
11. Renal effects
In the examination of whether γ-tocotrienol (GT3) protects against mitochondrial dysfunction and renal proximal tubular cell (RPTC) injury caused by oxidants, showed that report demonstrating the protective effects of GT3 against RPTC injury by 1) decreasing the production of ROS, 2) improving mitochondrial respiration, coupling, ΔΨ(m), and F₀F₁-ATPase function, 3) maintaining ATP levels, and 4) preventing RPTC lysis. Our data suggest that GT3 is superior to AT in protecting RPTCs against oxidant injury and may prove therapeutically valuable for preventing renal injury associated with oxidative stress, according to "γ-Tocotrienol protects against mitochondrial dysfunction and renal cell death" by Nowak G, Bakajsova D, Hayes C, Hauer-Jensen M, Compadre CM.(11)
12. Etc.
Back to Popular Herbs http://kylejnorton.blogspot.ca/p/popular-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20716280
(2) http://www.ncbi.nlm.nih.gov/pubmed/19748925
(3) http://www.ncbi.nlm.nih.gov/pubmed/22308007
(4) http://www.ncbi.nlm.nih.gov/pubmed/22293208
(5) http://www.mdpi.com/1422-0067/12/12/8846/
(6) http://www.ncbi.nlm.nih.gov/pubmed/22254089
(7) http://www.ncbi.nlm.nih.gov/pubmed/14521714
(8) http://www.ncbi.nlm.nih.gov/pubmed/22229304
(9) http://www.ncbi.nlm.nih.gov/pubmed/22226829
(10) http://www.ncbi.nlm.nih.gov/pubmed/22192241
(11) http://www.ncbi.nlm.nih.gov/pubmed/22040679
#Berry Crude #Extract Inhibits β-Amyloid Aggregation Associated with the Onset of #Alzheimer's disease (AD), Researchers Suggest
Kyle J. Norton
Amyloid beta (Aβ or Abeta) is the main component of the amyloid plaques that cause the gradual death of neurons, leading to the onset of Alzheimer's disease.
Alzheimer's disease is a common form of dementia or neurodegenerative disease found in the elderly.
Alzheimer's disease is a type of dementia correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.
According to the statistics, the disease is most prevalent in the elderly. Approximately 5.7 million Americans of all ages are living with Alzheimer's. 15.9 million family caregivers provide an estimated 18.2 billion hours and $230 billion to people with dementia worldwide.
Alzheimer's disease is caused by a combination of genetic, lifestyle, and environmental factors that affect the neurons of the brain over time. However, less than 10% of patients with AD are associated with a genetic predisposition. Patients with such mutated genes on chromosomes 21, 14, and 1 are virtually guaranteed to develop the disease.
More precisely, Alzheimer's disease is caused by the gradual loss of neuron functioning that usually starts with the early symptom of the difficulty of remembering recent events and worsens over time.
Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies, or social life. Alzheimer's gets worse over time, and it is fatal.
Dementia is a group of neurodegenerative diseases caused by a decline in mental ability in the older population that is severe enough to interfere with daily life, such as memory loss.
Compared to dementia, neurological disorders are a class of brain diseases associated with reduced function of the brain, depending on the region of the neurons that were affected.
Dr. Rudolph E. Tanzi said, "The inheritance of AD exhibits a dichotomous pattern. On one hand, rare mutations in APP, PSEN1, and PSEN2 virtually guarantee early-onset (<60 years) familial AD, which represents ∼5% of AD. On the other hand, common gene polymorphisms, such as the ε4 and ε2 variants of the APOE gene, can influence susceptibility for ∼50% of the common late-onset AD".
And, " These four genes account for 30%–50% of the inheritability of AD".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of neurodegenerative disorders, researchers examined the effect of cranberry extract (CE) on Alzheimer's disease (AD)associated with the aggregation and toxicity of proteins β-amyloid (Aβ).
The study is to compare the effects of berry crude extracts (CE) that yield anthocyanins-free (ACF) and anthocyanins-enriched (ACE) extracts.
According to the tested analysis, the berry ACEs (at 100 μg/mL) showed superior free radical scavenging, reactive carbonyl species trapping, and anti-glycation effects, compared to ACFs.
Furthermore, the berry ACEs at a dose of 100 μg/mL inhibited both thermal- and reactive carbonyl species (methylglyoxal; MGO)-induced Aβ fibrillation associated with the production of pro-inflammatory cytokines.
In BV-2 microglia, the berry ACEs at a dose of 20 μg/mL reduced H₂O₂-induced reactive oxygen species production and lipopolysaccharide-induced nitric oxide species.
Based on the findings, researchers said, "The free radical scavenging, reactive carbonyl trapping, anti-glycation, anti-Aβ fibrillation, and microglial neuroprotective effects of these berry extracts warrant further in vivo studies to evaluate their potential neuroprotective effects against AD.".
Taken together, berries including cranberry processed abundantly anthocyanins may be considered remedies for the prevention of β-Amyloid Aggregation against the onset of AD, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects by Ma H1,2,3, Johnson SL4,5, Liu W6, DaSilva NA7,8, Meschwitz S9, Dain JA10, Seeram NP. (PubMed)
(2) The Genetics of Alzheimer's Disease by Rudolph E. Tanzi. (NCBI)
Amyloid beta (Aβ or Abeta) is the main component of the amyloid plaques that cause the gradual death of neurons, leading to the onset of Alzheimer's disease.
Alzheimer's disease is a common form of dementia or neurodegenerative disease found in the elderly.
Alzheimer's disease is a type of dementia correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.
According to the statistics, the disease is most prevalent in the elderly. Approximately 5.7 million Americans of all ages are living with Alzheimer's. 15.9 million family caregivers provide an estimated 18.2 billion hours and $230 billion to people with dementia worldwide.
Alzheimer's disease is caused by a combination of genetic, lifestyle, and environmental factors that affect the neurons of the brain over time. However, less than 10% of patients with AD are associated with a genetic predisposition. Patients with such mutated genes on chromosomes 21, 14, and 1 are virtually guaranteed to develop the disease.
More precisely, Alzheimer's disease is caused by the gradual loss of neuron functioning that usually starts with the early symptom of the difficulty of remembering recent events and worsens over time.
Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies, or social life. Alzheimer's gets worse over time, and it is fatal.
Dementia is a group of neurodegenerative diseases caused by a decline in mental ability in the older population that is severe enough to interfere with daily life, such as memory loss.
Compared to dementia, neurological disorders are a class of brain diseases associated with reduced function of the brain, depending on the region of the neurons that were affected.
Dr. Rudolph E. Tanzi said, "The inheritance of AD exhibits a dichotomous pattern. On one hand, rare mutations in APP, PSEN1, and PSEN2 virtually guarantee early-onset (<60 years) familial AD, which represents ∼5% of AD. On the other hand, common gene polymorphisms, such as the ε4 and ε2 variants of the APOE gene, can influence susceptibility for ∼50% of the common late-onset AD".
And, " These four genes account for 30%–50% of the inheritability of AD".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of neurodegenerative disorders, researchers examined the effect of cranberry extract (CE) on Alzheimer's disease (AD)associated with the aggregation and toxicity of proteins β-amyloid (Aβ).
The study is to compare the effects of berry crude extracts (CE) that yield anthocyanins-free (ACF) and anthocyanins-enriched (ACE) extracts.
According to the tested analysis, the berry ACEs (at 100 μg/mL) showed superior free radical scavenging, reactive carbonyl species trapping, and anti-glycation effects, compared to ACFs.
Furthermore, the berry ACEs at a dose of 100 μg/mL inhibited both thermal- and reactive carbonyl species (methylglyoxal; MGO)-induced Aβ fibrillation associated with the production of pro-inflammatory cytokines.
In BV-2 microglia, the berry ACEs at a dose of 20 μg/mL reduced H₂O₂-induced reactive oxygen species production and lipopolysaccharide-induced nitric oxide species.
Based on the findings, researchers said, "The free radical scavenging, reactive carbonyl trapping, anti-glycation, anti-Aβ fibrillation, and microglial neuroprotective effects of these berry extracts warrant further in vivo studies to evaluate their potential neuroprotective effects against AD.".
Taken together, berries including cranberry processed abundantly anthocyanins may be considered remedies for the prevention of β-Amyloid Aggregation against the onset of AD, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects by Ma H1,2,3, Johnson SL4,5, Liu W6, DaSilva NA7,8, Meschwitz S9, Dain JA10, Seeram NP. (PubMed)
(2) The Genetics of Alzheimer's Disease by Rudolph E. Tanzi. (NCBI)
3,3'-Diindolylmethane Inhibits Pro-Inflammatory Cytokines Associated with the Onset of #Arthritis, Researchers Say
Kyle J. Norton
Arthritis is a group of diseases associated with the inflammation of the joints. According to epidemiological studies, osteoarthritis (OA) and rheumatoid arthritis (RA) are the 2 most common types of arthritis.
According to the information provided by the arthritis foundation, arthritis affects over 54 million people in adults and is diagnosed by doctors. Osteoarthritis is the most prevalent type in the US, affecting 31 million Americans.
Depending on type and the location affected, arthritis can be classified into over 100 conditions, but the most common types of arthritis include
* Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.
* Osteoarthritis (OA), is a condition caused by the wear and tear on a joint due to aging, affecting over 25 million people in the United States alone.
* Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.
* Polymyalgia arthritis is a condition of inflammatory rheumatic disease-induced pain, stiffness, and tenderness in large muscles, including muscle shoulders and pelvic girdle.
* Fibromyalgia the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result of responding to pressure.
As of today, there is no cure for arthritis, medications used in conventional medicine are to reduce pain, and symptoms and improve the quality of life for patients to carry out daily activities.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.
In the urgency to discover a natural compound for the treatment of diseases associated with osteoclastogenesis, researchers investigated the therapeutic efficacies of DIM on experimental arthritis.
The study included a rat model of adjuvant-induced arthritis (AIA), with daily AIA paw swelling.
According to the clinical and histologic indices of inflammation and tissue damage, administration of DIM attenuated AIA in animal models.
Furthermore, DIM also reduced the expression of several inflammatory cytokines, associated with the onset of arthritis. However, the anti-inflammatory function of DIM could not prevent the development of arthritis.
Moreover, in the differentiation of the DIM effect on activation-induced cytokine, researchers found that the bioactive compound effectively inhibits the expression of RANKL, leading to the blockade of osteoclastogenesis and consequently an alleviation of experimental arthritis.
The receptor activator of nuclear factor kappa-Β ligand (RANKL) is a protein involved in the activation-induced cytokine, osteoprotegerin ligand, and osteoclast differentiation factor.
Dr. the lead researcher wrote, "DIM has shown anti-arthritis activity in animal models via inhibiting the expression of RANKL, and thus may offer potential treatments for arthritis and associated disorders".
Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of arthritis, pending the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic bone resorption in mice by Yu TY1, Pang WJ2, Yang GS. (PubMed)
(2) 3,3'-Diindolylmethane attenuates experimental arthritis and osteoclastogenesis by Dong L1, Xia S, Gao F, Zhang D, Chen J, Zhang J. (PubMed)
Arthritis is a group of diseases associated with the inflammation of the joints. According to epidemiological studies, osteoarthritis (OA) and rheumatoid arthritis (RA) are the 2 most common types of arthritis.
According to the information provided by the arthritis foundation, arthritis affects over 54 million people in adults and is diagnosed by doctors. Osteoarthritis is the most prevalent type in the US, affecting 31 million Americans.
Depending on type and the location affected, arthritis can be classified into over 100 conditions, but the most common types of arthritis include
* Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.
* Osteoarthritis (OA), is a condition caused by the wear and tear on a joint due to aging, affecting over 25 million people in the United States alone.
* Rheumatoid Arthritis is a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body.
* Polymyalgia arthritis is a condition of inflammatory rheumatic disease-induced pain, stiffness, and tenderness in large muscles, including muscle shoulders and pelvic girdle.
* Fibromyalgia the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result of responding to pressure.
As of today, there is no cure for arthritis, medications used in conventional medicine are to reduce pain, and symptoms and improve the quality of life for patients to carry out daily activities.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.
In the urgency to discover a natural compound for the treatment of diseases associated with osteoclastogenesis, researchers investigated the therapeutic efficacies of DIM on experimental arthritis.
The study included a rat model of adjuvant-induced arthritis (AIA), with daily AIA paw swelling.
According to the clinical and histologic indices of inflammation and tissue damage, administration of DIM attenuated AIA in animal models.
Furthermore, DIM also reduced the expression of several inflammatory cytokines, associated with the onset of arthritis. However, the anti-inflammatory function of DIM could not prevent the development of arthritis.
Moreover, in the differentiation of the DIM effect on activation-induced cytokine, researchers found that the bioactive compound effectively inhibits the expression of RANKL, leading to the blockade of osteoclastogenesis and consequently an alleviation of experimental arthritis.
The receptor activator of nuclear factor kappa-Β ligand (RANKL) is a protein involved in the activation-induced cytokine, osteoprotegerin ligand, and osteoclast differentiation factor.
Dr. the lead researcher wrote, "DIM has shown anti-arthritis activity in animal models via inhibiting the expression of RANKL, and thus may offer potential treatments for arthritis and associated disorders".
Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of arthritis, pending the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic bone resorption in mice by Yu TY1, Pang WJ2, Yang GS. (PubMed)
(2) 3,3'-Diindolylmethane attenuates experimental arthritis and osteoclastogenesis by Dong L1, Xia S, Gao F, Zhang D, Chen J, Zhang J. (PubMed)
Saturday, 2 September 2023
#Broccolisprout #Extract (BSE) Protects the Liver by Inhibiting the Onset of Oxidative Stress, Researchers Reveal
Kyle J. Norton
Oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily donate or steal an electron from other molecules, leading to the chain of domino effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
In some cases, this reaction also causes long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.
Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.
In other words, antioxidants inhibit the onset of free radicals before they can cause a chain reaction in facilitating protein, lipid, and cell damage.
Antioxidants can either be produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.
There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, and oxidative bursts from activated macrophages, particularly, the free radicals chain reaction.
Sadly, a prolonged period of oxidative stress present in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.
Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetes, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
In finding a potential plant that processes anti-oxidative activity researchers examined the efficacy of sulforaphane found in broccoli in protecting alcohol-induced hepatic injury in vivo.
The study included selected male C57BL/6 mice which were orally administrated with broccoli sprout extract (BSE) containing sulforaphane [7.6, 25.2, and 50.4 mg/kg of body weight (bw)] once a day for 14 days.
On the 13th day, mice were challenged with alcohol (5 g/kg of bw) every 12 h for 3 times, which increased malondialdehyde (MDA) levels (4.44 ± 1.24 nmol/mg of protein, p < 0.01) of oxidative stress in the liver.
According to the results of the experiment, the administration of low-, medium-, and high-dose BSE markedly reversed the decrease in antioxidant capacity.
More precisely, BSE increased the levels of antioxidant enzymes such as glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and glutathione S-transferase (GST) in the liver, compared to control.
The efficacy in protecting the liver from oxidative stress was attributed to the activation of phase 2 enzymes via nuclear erythroid-2-related factor 2 (Nrf2).
Most importantly, BSE also significantly attenuated the levels of the endoplasmic reticulum (ER)-stress-specific proteins, a defense system that protects cells from ER stress such as glucose-regulated protein 78 (GRP78), activating transcription factor 6, and protein kinase RNA (PKR)-like ER kinase (PERK),
Collectively, researchers said, "These results indicate that BSE protects the liver against alcohol challenge via upregulating antioxidant capacity and downregulating ER stress".
Taken together, broccoli may be considered a functional food for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Broccoli Sprout Extract Alleviates Alcohol-Induced Oxidative Stress and Endoplasmic Reticulum Stress in C57BL/6 Mice by Lei P1, Zhao W1, Pang B1, Yang X1, Li BL2,3, Ren M4, Shan YJ. (PubMed)
Oxidative stress is a medical condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily donate or steal an electron from other molecules, leading to the chain of domino effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
In some cases, this reaction also causes long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.
Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.
In other words, antioxidants inhibit the onset of free radicals before they can cause a chain reaction in facilitating protein, lipid, and cell damage.
Antioxidants can either be produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.
There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, and oxidative bursts from activated macrophages, particularly, the free radicals chain reaction.
Sadly, a prolonged period of oxidative stress present in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.
Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetes, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.
In finding a potential plant that processes anti-oxidative activity researchers examined the efficacy of sulforaphane found in broccoli in protecting alcohol-induced hepatic injury in vivo.
The study included selected male C57BL/6 mice which were orally administrated with broccoli sprout extract (BSE) containing sulforaphane [7.6, 25.2, and 50.4 mg/kg of body weight (bw)] once a day for 14 days.
On the 13th day, mice were challenged with alcohol (5 g/kg of bw) every 12 h for 3 times, which increased malondialdehyde (MDA) levels (4.44 ± 1.24 nmol/mg of protein, p < 0.01) of oxidative stress in the liver.
According to the results of the experiment, the administration of low-, medium-, and high-dose BSE markedly reversed the decrease in antioxidant capacity.
More precisely, BSE increased the levels of antioxidant enzymes such as glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and glutathione S-transferase (GST) in the liver, compared to control.
The efficacy in protecting the liver from oxidative stress was attributed to the activation of phase 2 enzymes via nuclear erythroid-2-related factor 2 (Nrf2).
Most importantly, BSE also significantly attenuated the levels of the endoplasmic reticulum (ER)-stress-specific proteins, a defense system that protects cells from ER stress such as glucose-regulated protein 78 (GRP78), activating transcription factor 6, and protein kinase RNA (PKR)-like ER kinase (PERK),
Collectively, researchers said, "These results indicate that BSE protects the liver against alcohol challenge via upregulating antioxidant capacity and downregulating ER stress".
Taken together, broccoli may be considered a functional food for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Broccoli Sprout Extract Alleviates Alcohol-Induced Oxidative Stress and Endoplasmic Reticulum Stress in C57BL/6 Mice by Lei P1, Zhao W1, Pang B1, Yang X1, Li BL2,3, Ren M4, Shan YJ. (PubMed)
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