Kyle J. Norton
Osteosarcoma is a type of bone cancer found mostly in teenagers and people over age 60.
Most cases of osteosarcoma are associated with genetic syndromes. In other words, Osteosarcoma is associated with a genetic preposition inherited from the parent.
According to the statistics from the American Cancer Society, each year, approximately 800 to 900 new cases of osteosarcoma are diagnosed in the United States with half of these in children and teens.
The exact causes of osteosarcoma are unidentified. However, epidemiologically, besides gene expression, an unhealthy lifestyle such as body weight, physical activity, diet, and tobacco, gender, age, height, ethnicity, and exposure to bone radiation are also some prevalent factors found in patients with the disease.
Dr. Jeff W. Martin, the lead scientist at the Hospital for Sick Children and Queen's University wrote, "The etiology of this often aggressive cancer is currently unknown because complicated structural and numeric genomic rearrangements in cancer cells preclude the understanding of tumor development.",
And, " few consistent genetic changes that may indicate effective molecular therapeutic targets have been reported. However, high-resolution techniques continue to improve knowledge of distinct areas of the genome that are more commonly associated with osteosarcomas".
The overall 5-year survival rate for children and teens with osteosarcoma is 70%. If cancer has spread to the lung, the 5-year survival rate is only 40% compared to localized cancer between 60% to 80%.
Conventionally, most cases of osteosarcoma are o treated with a combination of surgery, chemotherapy, and radiation therapy.
In patients with high-grade tumors, before surgery, neo-adjuvant therapy may be necessary to shrink the tumor.
Ashwagandha (WA)also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In finding a potent compound for the treatment of cancers, researchers examined and evaluated the safety and pharmacokinetics of WA.
In Vitro, Withaferin-A (WF-A), a major bioactive compound found in WA exhibited strong antiproliferative activity against several osteosarcoma cell lines, with IC50 ranging from 0.32 to 7.6 μM. The lowest IC50 (0.32 μM).
At the lowest IC50 (0.32 μM), WF-A showed a significant effect on the inhibition of the U2OS cell line, compared to other cell lines.
Most importantly, WF-A induced ROS cytotoxicity against the tested cell lines in a dose-dependent manner and activation of cell death protein in osteosarcoma cells.
In the safety analysis, if the phase I dose-escalation study, using the classical 3 + 3 design (C33D) is comprised of 72, 108, 144 and 216 mg of WA administered in two to four divided doses per day in selected patients, including 3 patients enrolled in each cohort with the last patient who was observed for at least 30 days for any dose-limiting toxicity before progressing to a higher cohort, researchers found that the formulation was generally well tolerated with no grade 3 or grade 4 adverse events were observed, however, the formulation at the tested doses caused 11 adverse events of grade 1 or grade 2 severity.
Mose common symptoms are fatigue, fever, edema, and diarrhea. No levels of WA circulation. were found in the blood plasma. The low oral bioavailability of WA was also observed during the experimental period.
Based on the findings, researchers wrote, "The formulation was well tolerated. However, WA appears to have low oral bioavailability. Further studies with improved formulations are warranted".
Taken together, Ashwagandha is safe and may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of osteosarcomas, pending the result of a larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Safety and Pharmacokinetics of Withaferin-A in advanced stage high-grade Osteosarcoma: A phase I trial by Pires N1, Gota V1, Gulia A2, Hingorani L3, Agarwal M2, Puri A. (PubMed)
(2) Withaferin-A Induces Apoptosis in Osteosarcoma U2OS Cell Line via Generation of ROS and Disruption of Mitochondrial Membrane Potential by Zhang HL1,2, Zhang H. (PubMed)
(3) The Genetics of Osteosarcoma by Jeff W. Martin,1 Jeremy A. Squire,2 and Maria Zielenska. (Hindawi)
Wednesday, 30 August 2023
#Herbal #Angelica Combined with #Danshen, #Gegen, and #Chuanxiong Process Dual Antiplatelet Therapy (DAPT), Scientists Say
Kyle J. Norton
Platelets are tiny blood cells that prevent injury and infection by forming clots to stop bleeding.
Antiplatelet activity is an action that prevents and treats blood clots.
Anticoagulants, commonly known as blood thinners, are conventional medicines used to reduce the coagulation of blood, and prolong the clotting time.
Anticoagulants have been used widely for people with a high risk of heart disease and stroke due to narrowing arteries associated with plaque accumulation on the arterial walls.
Platelets are made in the bone marrow which also produces white and red blood cells.
Diseases associated with low and abnormal blood platelets include
* Thrombocytopenia is a condition characterized by low blood platelets due to abnormal function of the bone marrow that makes platelets. patients with thrombocytopenia due to the low quantity of blood platelets may experience symptoms of a bruise, internal bleeding, or nosebleed.
Long-term untreated thrombocytopenia has been found to increase the risk of cancer, liver disease, pregnancy, infections, and an abnormal immune system.
* Essential thrombocythemia is a disease associated with overproducing blood platelets by the bone marrow, leading to symptoms of blood clots that form and block the blood supply to the brain or the heart.
* Secondary thrombocytosis is also another condition caused by too many platelets produced by the bone marrow.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
In finding a natural compound for the treatment of platelet aggression, the researchers examined the impact of these four commonly used Chinese medicinal herbs on the pharmacokinetics and pharmacodynamics of the combination therapy with clopidogrel and aspirin.
In order to mimic the standard dosing regimen for dual antiplatelet therapy (DAPT) in humans, Sprague-Dawley rats treatment groups received a bolus oral dose of DAPT on day 1 followed by DAPT for consecutive 13 days in the absence and presence of orally co-administered four TCM herbs (Danshen, Gegen, Danggui, and Chuanxiong) at their low and high doses.
According to the results on day 14, and observed the plasma concentrations of aspirin (ASA) and clopidogrel (CLP) and their corresponding metabolites,
* Co-administration of Gegen and Danggui significantly altered the pharmacokinetics of ASA and CLP in DAPT with increased systemic exposure to ASA and CLP respectively.
Furthermore, DAPT with Danshen, Gegen, and Danggui co-treatment. significant inhibition on rCyp2c11 that enzymes mediate the metabolism of ASA and carboxylesterase activities in drug metabolism, compared to a minimal impact on aspirin esterase activity in all co-administered herbs.
Moreover. all DAPT treatment groups showed a significantly longer prothrombin time (PT) compared to a decrease of the DAPT group in the presence of Gegen, Danggui, and Chuanxiong with no change to other coagulative expressions.
Taken altogether, Herbal Angelica combined with other herbal medicines may be used as a remedy to offset the anticoagulant activity of DAPT, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Impact of the Chinese herbal medicines on dual antiplatelet therapy with clopidogrel and aspirin: Pharmacokinetics and pharmacodynamics outcomes and related mechanisms in rats by Xiao M1, Qian C2, Luo X3, Yang M4, Zhang Y5, Wu C6, Mok C7, Lee P8, Zuo Z. (PubMed)
Platelets are tiny blood cells that prevent injury and infection by forming clots to stop bleeding.
Antiplatelet activity is an action that prevents and treats blood clots.
Anticoagulants, commonly known as blood thinners, are conventional medicines used to reduce the coagulation of blood, and prolong the clotting time.
Anticoagulants have been used widely for people with a high risk of heart disease and stroke due to narrowing arteries associated with plaque accumulation on the arterial walls.
Platelets are made in the bone marrow which also produces white and red blood cells.
Diseases associated with low and abnormal blood platelets include
* Thrombocytopenia is a condition characterized by low blood platelets due to abnormal function of the bone marrow that makes platelets. patients with thrombocytopenia due to the low quantity of blood platelets may experience symptoms of a bruise, internal bleeding, or nosebleed.
Long-term untreated thrombocytopenia has been found to increase the risk of cancer, liver disease, pregnancy, infections, and an abnormal immune system.
* Essential thrombocythemia is a disease associated with overproducing blood platelets by the bone marrow, leading to symptoms of blood clots that form and block the blood supply to the brain or the heart.
* Secondary thrombocytosis is also another condition caused by too many platelets produced by the bone marrow.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
In finding a natural compound for the treatment of platelet aggression, the researchers examined the impact of these four commonly used Chinese medicinal herbs on the pharmacokinetics and pharmacodynamics of the combination therapy with clopidogrel and aspirin.
In order to mimic the standard dosing regimen for dual antiplatelet therapy (DAPT) in humans, Sprague-Dawley rats treatment groups received a bolus oral dose of DAPT on day 1 followed by DAPT for consecutive 13 days in the absence and presence of orally co-administered four TCM herbs (Danshen, Gegen, Danggui, and Chuanxiong) at their low and high doses.
According to the results on day 14, and observed the plasma concentrations of aspirin (ASA) and clopidogrel (CLP) and their corresponding metabolites,
* Co-administration of Gegen and Danggui significantly altered the pharmacokinetics of ASA and CLP in DAPT with increased systemic exposure to ASA and CLP respectively.
Furthermore, DAPT with Danshen, Gegen, and Danggui co-treatment. significant inhibition on rCyp2c11 that enzymes mediate the metabolism of ASA and carboxylesterase activities in drug metabolism, compared to a minimal impact on aspirin esterase activity in all co-administered herbs.
Moreover. all DAPT treatment groups showed a significantly longer prothrombin time (PT) compared to a decrease of the DAPT group in the presence of Gegen, Danggui, and Chuanxiong with no change to other coagulative expressions.
Taken altogether, Herbal Angelica combined with other herbal medicines may be used as a remedy to offset the anticoagulant activity of DAPT, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Impact of the Chinese herbal medicines on dual antiplatelet therapy with clopidogrel and aspirin: Pharmacokinetics and pharmacodynamics outcomes and related mechanisms in rats by Xiao M1, Qian C2, Luo X3, Yang M4, Zhang Y5, Wu C6, Mok C7, Lee P8, Zuo Z. (PubMed)
#Lycopene Reduces Inflammation Induced by Cigarette Smoke (CS), Researchers Reveal
Kyle J. Norton
Inflammation is a natural response of the immune systematics reaction that protects the body against invasive foreign microorganisms.
In the acute phase of infection, the macrophage of the largest white blood cells of the first line of defense not only stimulates the production of blood platelets to cover the site of damage but also induces the production of pro-inflammatory cytokines to fend off foreign invaders.
During the acute phase of infection, depending on the individual immune system capacity, overproduction of proinflammatory cytokines may cause damage to nearby healthy cells, leading to the formation of scars in some people.
Most cases of infection are stopped at the acute phase of infection. The wound is slowly healed itself within a few days or weeks.
However, if the immune system can not destroy all pathogens within a set of period time ( 3 to 8 weeks) it will compromise, leading to chronic inflammation.
In other words, chronic inflammation occurs when the immune response lingers, causing low-grade inflammation. Chronic inflammation over time may damage proteins, lipids, and cells of the body tissues.
The infection may be latent in which the pathogen remains within the body for a long time without producing any symptoms, such as the hepatitis virus.
Diseases associated with chronic inflammation include cancer, heart disease, rheumatoid arthritis, type 2 diabetes, and obesity.
Anti-inflammation is a treatment that not only reduces inflammation or swelling but also protects the damaged tissue against the formation of a scar without affecting the immune function in killing foreign invaders.
Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to find potential ingredients with anti-inflammatory properties, researchers examined the effects of lycopene on reducing inflammation induced by cigarette smoke (CS).
In vivo, according to the study of 40 mice divided into 5 groups: a control exposed to ambient air (CG), a vehicle-control group that received 200 μl of sunflower oil by orogastric gavage, a group exposed to CS and two groups administered lycopene (diluted in sunflower oil) at doses of either 25 or 50 mg/kg/day prior to exposure to CS (LY25+CS and LY50+CS) for 5 days,
* There was an increase in ROS production in 24 h in CS compared with CG.
* Lycopene administrated at concentrations of 1 μM and 2 μM were able to reduce the production of ROS in 24 h compared with CS.
* Administration with lycopene at the highest dose suppressed the CS-induced increase of leukocytes.
* Lipid peroxidation and DNA damage increased in the CS group compared with that in the controls and was also suppressed by lycopene at the highest dose.
* Furthermore, the decrease of superoxide dismutase and catalase activity in the CS group compared with that in the controls was also reduced in the LY25+CS and LY50+CS groups.
* Lycopene also inhibited the expression of proteins associated with the production of pro-inflammatory cytokines such as tumor necrosis factor-α, interferon-γ, and interleukin-10 after exposure to CS.
In vitro, observation of the results of lipopolysaccharide (LPS)-stimulated SW 480 human colorectal cancer cells found that
* Lycopene at a dose-dependent manner decreased the expression of mRNA associated with protein in the initiation of the production of pro-inflammatory cytokines similar to that of the aforementioned study.
* Lycopene also inhibited the concentrations of mediators prostaglandins -2 (PGE2) and nitric oxide (NO) associated with the onset of inflammation.
* Additionally, lycopene blocks the activation of nuclear transcription factor-κB (NF-κB) and Jun N-terminal kinase (JNK) which cause inflammation.
Taken altogether, lycopene found in tomatoes may be considered a supplement for the prevention of inflammation, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The antioxidant and anti-inflammatory properties of lycopene in mice lungs exposed to cigarette smoke by Campos KKD1, Araújo GR2, Martins TL1, Bandeira ACB2, Costa GP3, Talvani A3, Garcia CCM4, Oliveira LAM5, Costa DC2, Bezerra FS. (PubMed)
(2) Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells by Cha JH1, Kim WK1, Ha AW1, Kim MH2, Chang MJ. (PubMed)
Inflammation is a natural response of the immune systematics reaction that protects the body against invasive foreign microorganisms.
In the acute phase of infection, the macrophage of the largest white blood cells of the first line of defense not only stimulates the production of blood platelets to cover the site of damage but also induces the production of pro-inflammatory cytokines to fend off foreign invaders.
During the acute phase of infection, depending on the individual immune system capacity, overproduction of proinflammatory cytokines may cause damage to nearby healthy cells, leading to the formation of scars in some people.
Most cases of infection are stopped at the acute phase of infection. The wound is slowly healed itself within a few days or weeks.
However, if the immune system can not destroy all pathogens within a set of period time ( 3 to 8 weeks) it will compromise, leading to chronic inflammation.
In other words, chronic inflammation occurs when the immune response lingers, causing low-grade inflammation. Chronic inflammation over time may damage proteins, lipids, and cells of the body tissues.
The infection may be latent in which the pathogen remains within the body for a long time without producing any symptoms, such as the hepatitis virus.
Diseases associated with chronic inflammation include cancer, heart disease, rheumatoid arthritis, type 2 diabetes, and obesity.
Anti-inflammation is a treatment that not only reduces inflammation or swelling but also protects the damaged tissue against the formation of a scar without affecting the immune function in killing foreign invaders.
Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to find potential ingredients with anti-inflammatory properties, researchers examined the effects of lycopene on reducing inflammation induced by cigarette smoke (CS).
In vivo, according to the study of 40 mice divided into 5 groups: a control exposed to ambient air (CG), a vehicle-control group that received 200 μl of sunflower oil by orogastric gavage, a group exposed to CS and two groups administered lycopene (diluted in sunflower oil) at doses of either 25 or 50 mg/kg/day prior to exposure to CS (LY25+CS and LY50+CS) for 5 days,
* There was an increase in ROS production in 24 h in CS compared with CG.
* Lycopene administrated at concentrations of 1 μM and 2 μM were able to reduce the production of ROS in 24 h compared with CS.
* Administration with lycopene at the highest dose suppressed the CS-induced increase of leukocytes.
* Lipid peroxidation and DNA damage increased in the CS group compared with that in the controls and was also suppressed by lycopene at the highest dose.
* Furthermore, the decrease of superoxide dismutase and catalase activity in the CS group compared with that in the controls was also reduced in the LY25+CS and LY50+CS groups.
* Lycopene also inhibited the expression of proteins associated with the production of pro-inflammatory cytokines such as tumor necrosis factor-α, interferon-γ, and interleukin-10 after exposure to CS.
In vitro, observation of the results of lipopolysaccharide (LPS)-stimulated SW 480 human colorectal cancer cells found that
* Lycopene at a dose-dependent manner decreased the expression of mRNA associated with protein in the initiation of the production of pro-inflammatory cytokines similar to that of the aforementioned study.
* Lycopene also inhibited the concentrations of mediators prostaglandins -2 (PGE2) and nitric oxide (NO) associated with the onset of inflammation.
* Additionally, lycopene blocks the activation of nuclear transcription factor-κB (NF-κB) and Jun N-terminal kinase (JNK) which cause inflammation.
Taken altogether, lycopene found in tomatoes may be considered a supplement for the prevention of inflammation, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The antioxidant and anti-inflammatory properties of lycopene in mice lungs exposed to cigarette smoke by Campos KKD1, Araújo GR2, Martins TL1, Bandeira ACB2, Costa GP3, Talvani A3, Garcia CCM4, Oliveira LAM5, Costa DC2, Bezerra FS. (PubMed)
(2) Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells by Cha JH1, Kim WK1, Ha AW1, Kim MH2, Chang MJ. (PubMed)
#Isorhamnetin and Myricetin Found in #Cranberry Inhibit #BladderCancer Cells in Vitro, Researchers Suggest
Kyle J. Norton
The bladder-formed part of the secretory system is a muscular sac in the pelvis, just above and behind the pubic bone.
The bladder has 2 main functions store the urine made in the kidneys and control urinary secretion.
Cancer is a group of chronic diseases characterized by cell growth that starts on the surface of the inner lining tissue of a specific tissue of a gland or organ.
Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women, Bladder cancer usually starts from the cells on the surface of the inner tissue that lines the bladder.
Bladder cancer depending on the origination of the cancer beginning can be classified into
* Transitional cell carcinoma
In the early stage of bladder cancer, normal cells become cancerous in the innermost tissue layer of the bladder which can change shape and stretch without breaking apart. In other words, cancer in this stage is able to stretch when the bladder is full and shrink when the bladder is emptied.
More than 90 percent of bladder cancers begin in the transitional cells
* Squamous cell carcinoma
Cancer begins in squamous cells found in the tissues of the surface of the bladder, due to long-term infection or irritation. About 8 percent of people with bladder cancers begin with squamous cells.
* Adenocarcinoma
Cancer originates from the glandular tissue of the bladder, including the surface layer of skin, glands, and a variety of other tissue, due to long-term irritation and inflammation. Only 2 percent of people with the condition have a third bladder cancer type.
The exact causes of bladder cancer are unidentified. However, smoking has been associated with a significant factor that causes the onset of the disease.
Dr. Neal D. Freedman, the lead scientist wrote, "Previous studies indicate that the population attributable risk of bladder cancer for tobacco smoking is 50–65% in men and 20–30% in women and that current cigarette smoking triples bladder cancer risk relative to never smoking".
And, "Over the last 30 years, incidence rates have remained stable in the United States (men: 123.8/100,000 person-years to 142.2/100,000 person-years; women: 32.5/100,000 person-years to 33.2/100,000 person-years)".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of bladder cancer, researchers examined the anti-proliferative activities of cranberry-derived flavonoids on human bladder tumor cell lines (RT4, SCABER, and SW-780) and non-tumorigenic immortalized human uroepithelial cells (SV-HUC).
According to the tested analysis,
* Quercetin 3-O-glucoside, isorhamnetin (3'-O-methyl quercetin), myricetin, and quercetin found in cranberry showed strong concentration-dependent cell growth inhibitory activities in bladder cancer cells with IC50 values in a range of 8-92 μM compared to others.
* Isorhamnetin and myricetin had very low inhibitory activity against SV-HUC even at very high concentrations (>200 μM) compared to bladder cancer cells.
These results strongly suggested that isorhamnetin and myricetin inhibited bladder cancer cells without causing harm to the nearby healthy cells.
Furthermore, according to the results of SW-780 cells incubated with the aforementioned compounds, hyperoside, a member of 3-O-galactoside of quercetin undergoes relatively less metabolic biotransformation (methylation, glucuronidation, and quinone formation) compared to quercetin 3-O-glucoside.
Based on the findings, researchers said, "Isorhamnetin and quercetin 3-O-glucoside may be the active forms of quercetin in the prevention of bladder cancer".
Taken altogether, cranberry-processed abundantly bioactive compounds may be considered a remedy for the prevention and treatment of bladder cancer pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells by Prasain JK1, Rajbhandari R1, Keeton AB2, Piazza GA2, Barnes S. (PubMed)
(2) Cranberries and Cancer: An Update of Preclinical Studies Evaluating the CancerInhibitory Potential of Cranberry and Cranberry Derived Constituents by Weh KM1, Clarke J2,3,4, Kresty LA. (PubMed)
(3) Association between smoking and risk of bladder cancer among men and women by Neal D Freedman, PhD, MPH,1 Debra T Silverman, ScD, ScM,1 Albert R Hollenbeck, Ph.D.,2Arthur Schatzkin, MD, DrPH,1 and Christian C Abnet, PhD, MPH. (PMC)
The bladder-formed part of the secretory system is a muscular sac in the pelvis, just above and behind the pubic bone.
The bladder has 2 main functions store the urine made in the kidneys and control urinary secretion.
Cancer is a group of chronic diseases characterized by cell growth that starts on the surface of the inner lining tissue of a specific tissue of a gland or organ.
Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women, Bladder cancer usually starts from the cells on the surface of the inner tissue that lines the bladder.
Bladder cancer depending on the origination of the cancer beginning can be classified into
* Transitional cell carcinoma
In the early stage of bladder cancer, normal cells become cancerous in the innermost tissue layer of the bladder which can change shape and stretch without breaking apart. In other words, cancer in this stage is able to stretch when the bladder is full and shrink when the bladder is emptied.
More than 90 percent of bladder cancers begin in the transitional cells
* Squamous cell carcinoma
Cancer begins in squamous cells found in the tissues of the surface of the bladder, due to long-term infection or irritation. About 8 percent of people with bladder cancers begin with squamous cells.
* Adenocarcinoma
Cancer originates from the glandular tissue of the bladder, including the surface layer of skin, glands, and a variety of other tissue, due to long-term irritation and inflammation. Only 2 percent of people with the condition have a third bladder cancer type.
The exact causes of bladder cancer are unidentified. However, smoking has been associated with a significant factor that causes the onset of the disease.
Dr. Neal D. Freedman, the lead scientist wrote, "Previous studies indicate that the population attributable risk of bladder cancer for tobacco smoking is 50–65% in men and 20–30% in women and that current cigarette smoking triples bladder cancer risk relative to never smoking".
And, "Over the last 30 years, incidence rates have remained stable in the United States (men: 123.8/100,000 person-years to 142.2/100,000 person-years; women: 32.5/100,000 person-years to 33.2/100,000 person-years)".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belonging to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of bladder cancer, researchers examined the anti-proliferative activities of cranberry-derived flavonoids on human bladder tumor cell lines (RT4, SCABER, and SW-780) and non-tumorigenic immortalized human uroepithelial cells (SV-HUC).
According to the tested analysis,
* Quercetin 3-O-glucoside, isorhamnetin (3'-O-methyl quercetin), myricetin, and quercetin found in cranberry showed strong concentration-dependent cell growth inhibitory activities in bladder cancer cells with IC50 values in a range of 8-92 μM compared to others.
* Isorhamnetin and myricetin had very low inhibitory activity against SV-HUC even at very high concentrations (>200 μM) compared to bladder cancer cells.
These results strongly suggested that isorhamnetin and myricetin inhibited bladder cancer cells without causing harm to the nearby healthy cells.
Furthermore, according to the results of SW-780 cells incubated with the aforementioned compounds, hyperoside, a member of 3-O-galactoside of quercetin undergoes relatively less metabolic biotransformation (methylation, glucuronidation, and quinone formation) compared to quercetin 3-O-glucoside.
Based on the findings, researchers said, "Isorhamnetin and quercetin 3-O-glucoside may be the active forms of quercetin in the prevention of bladder cancer".
Taken altogether, cranberry-processed abundantly bioactive compounds may be considered a remedy for the prevention and treatment of bladder cancer pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells by Prasain JK1, Rajbhandari R1, Keeton AB2, Piazza GA2, Barnes S. (PubMed)
(2) Cranberries and Cancer: An Update of Preclinical Studies Evaluating the CancerInhibitory Potential of Cranberry and Cranberry Derived Constituents by Weh KM1, Clarke J2,3,4, Kresty LA. (PubMed)
(3) Association between smoking and risk of bladder cancer among men and women by Neal D Freedman, PhD, MPH,1 Debra T Silverman, ScD, ScM,1 Albert R Hollenbeck, Ph.D.,2Arthur Schatzkin, MD, DrPH,1 and Christian C Abnet, PhD, MPH. (PMC)
#Ginger Combined with #Turmertic Significantly Suppress the Incidence and Severity of Arthritis, Researchers Say
Kyle J. Norton
Scientists may have found a whole food that processes a significant effect in reducing and treating arthritis with no side effects, some studies found. Arthritis is a class of inflammatory diseases that affect the joints.
The most common symptoms of arthritis are joint pain and stiffness.
However, some patients with arthritis may also experience symptoms of redness, warmth, swelling, and decreased range of motion of the affected joints.
The most common causes of arthritis are improper health of joint injury at a younger age and infections that affect the integrity of the cartilage.
RA, an autoimmune disorder is a type of arthritis caused by the immune system mistakenly attacking the joint tissues of the body.
The prevalent risk factors associated with the onset of the disease include the increase in age, family history, gender, ethnicity, and obesity.
Some researchers suggested that people who follow the Western diet with high saturated and trans fat, red meat and processed foods, and fewer fruits and vegetables and whole grains are also at an increased risk of arthritis.
According to the study published in the journal JCI Insight on April 19, by the University of Rochester Medical Center in New York, after 3 months of feeding mice a high-fat diet similar to that of a western “cheeseburger and milkshake” regimen, the mice became obese and diabetic and fat percentage was double compared to mice fed with a healthy, low-fat diet.
The contribution of overweight obesity caused by long-term intake of the Western diet may contribute to the link of obesity to the risk of arthritis.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to reconfirm the traditional medicine use of ginger for the treatment of chronic inflammatory diseases, the research team examined the turmeric (rich in curcuminoids) and ginger (rich in gingerols and shogaols) rhizomes effect in patients with arthritis rat adjuvant-induced arthritis (AIA) both plants at the dose 200 mg/kg body weight were orally administrated.
Turmeric and ginger significantly suppressed (but to different degrees) the incidence and severity of arthritis by increasing the production of anti-inflammatory and pro-inflammatory cytokines.
Both turmeric and ginger also restored the antioxidant enzymes in the rats.
In the anti-arthritic activity, turmeric was more effective compared to of ginger and indomethacin (a non-steroidal anti-inflammatory drug), especially when the treatment started from the day of arthritis induction.
Interestingly, The percentage of disease recovery was 4.6-8.3% and 10.2% more in turmeric compared with ginger and indomethacin, respectively.
Dr. the lead author said, after taking into account co and confounders, "the anti-inflammatory/anti-oxidant activity of turmeric over ginger and indomethacin, which may have beneficial effects against rheumatoid arthritis onset/progression as shown in AIA rat model".
The findings indicated a potential effect of ginger against arthritis although to a lesser extent than those of turmeric.
Furthermore, the investigation of the potential of hydroalcoholic extract of Zingiber officinale rhizomes (Z. officinale extract) in ameliorating inflammatory process in rat collagen-induced arthritis, also found that* Z. officinale extract in doses higher than 50 mg/kg/day intraperitoneally significantly enhanced the immune function against the progression of arthritis.
* Continued administration of the said volume for 26 days can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction.
* The anti-arthritis effects were associated with reduced production of proinflammatory cytokines and antibodies.
Most importantly, Z. officinale extract at the dose of 200 mg/kg/day was more superior to those of 2 mg/kg/day of indomethacin compared to most of the measured parameters.
Taken together, ginger may be used as a functional food for the prevention and combined with primary medicine for the treatment of arthritis
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis by Ramadan G1, Al-Kahtani MA, El-Sayed WM. (PubMed)
(2) Evaluation of the effect of hydroalcoholic extract of Zingiber officinale rhizomes in rat collagen-induced arthritis by Fouda AM1, Berika MY. (PubMed)
(3) Western Diet, With Its High-Fat Content, Linked To ArthritisApr 19, 2018 09:00 AM By Sadhana Bharanidharan, (Medical Daily)
Scientists may have found a whole food that processes a significant effect in reducing and treating arthritis with no side effects, some studies found. Arthritis is a class of inflammatory diseases that affect the joints.
The most common symptoms of arthritis are joint pain and stiffness.
However, some patients with arthritis may also experience symptoms of redness, warmth, swelling, and decreased range of motion of the affected joints.
The most common causes of arthritis are improper health of joint injury at a younger age and infections that affect the integrity of the cartilage.
RA, an autoimmune disorder is a type of arthritis caused by the immune system mistakenly attacking the joint tissues of the body.
The prevalent risk factors associated with the onset of the disease include the increase in age, family history, gender, ethnicity, and obesity.
Some researchers suggested that people who follow the Western diet with high saturated and trans fat, red meat and processed foods, and fewer fruits and vegetables and whole grains are also at an increased risk of arthritis.
According to the study published in the journal JCI Insight on April 19, by the University of Rochester Medical Center in New York, after 3 months of feeding mice a high-fat diet similar to that of a western “cheeseburger and milkshake” regimen, the mice became obese and diabetic and fat percentage was double compared to mice fed with a healthy, low-fat diet.
The contribution of overweight obesity caused by long-term intake of the Western diet may contribute to the link of obesity to the risk of arthritis.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to reconfirm the traditional medicine use of ginger for the treatment of chronic inflammatory diseases, the research team examined the turmeric (rich in curcuminoids) and ginger (rich in gingerols and shogaols) rhizomes effect in patients with arthritis rat adjuvant-induced arthritis (AIA) both plants at the dose 200 mg/kg body weight were orally administrated.
Turmeric and ginger significantly suppressed (but to different degrees) the incidence and severity of arthritis by increasing the production of anti-inflammatory and pro-inflammatory cytokines.
Both turmeric and ginger also restored the antioxidant enzymes in the rats.
In the anti-arthritic activity, turmeric was more effective compared to of ginger and indomethacin (a non-steroidal anti-inflammatory drug), especially when the treatment started from the day of arthritis induction.
Interestingly, The percentage of disease recovery was 4.6-8.3% and 10.2% more in turmeric compared with ginger and indomethacin, respectively.
Dr. the lead author said, after taking into account co and confounders, "the anti-inflammatory/anti-oxidant activity of turmeric over ginger and indomethacin, which may have beneficial effects against rheumatoid arthritis onset/progression as shown in AIA rat model".
The findings indicated a potential effect of ginger against arthritis although to a lesser extent than those of turmeric.
Furthermore, the investigation of the potential of hydroalcoholic extract of Zingiber officinale rhizomes (Z. officinale extract) in ameliorating inflammatory process in rat collagen-induced arthritis, also found that* Z. officinale extract in doses higher than 50 mg/kg/day intraperitoneally significantly enhanced the immune function against the progression of arthritis.
* Continued administration of the said volume for 26 days can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction.
* The anti-arthritis effects were associated with reduced production of proinflammatory cytokines and antibodies.
Most importantly, Z. officinale extract at the dose of 200 mg/kg/day was more superior to those of 2 mg/kg/day of indomethacin compared to most of the measured parameters.
Taken together, ginger may be used as a functional food for the prevention and combined with primary medicine for the treatment of arthritis
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis by Ramadan G1, Al-Kahtani MA, El-Sayed WM. (PubMed)
(2) Evaluation of the effect of hydroalcoholic extract of Zingiber officinale rhizomes in rat collagen-induced arthritis by Fouda AM1, Berika MY. (PubMed)
(3) Western Diet, With Its High-Fat Content, Linked To ArthritisApr 19, 2018 09:00 AM By Sadhana Bharanidharan, (Medical Daily)
#Imperatorin and #Isoimperatorin, Found in #Herbal #Angelica dahurica #Extract Inhibt the Risk of #ColonCancer, Researchers Show
Kyle J. Norton
Antioxidants are stable atoms produced either by the host body or intake of dietary antioxidants-rich food with the function that inhibits oxidation caused by free radicals.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily donate or steal an electron from other molecules, leading to the chain of domino effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer by inducing the alternation of lipids, proteins, and cell DNA damage.
Colon cancer is relatively very common and slowly growing and progressing in a predictable way.
Most cases of primary colon cancer start in the cells on the surface of the inner lining of the colon. At the early stage. most patients with colon cancer do not experience any symptoms.
However, at the advanced stage, the tumor not only can spread to other healthy tissues and organs a distance away through blood and fluid circulation but also suppress the nearby tissue and nerve cells.
The progression of colon cancer at this stage not only induces symptoms of the change in bowel habits, the change in the consistency of your stool, that lasts longer than four weeks but also causes rectal bleeding and persistent abdominal severe pain.
According to the statistics by the American Cancer Society, in the US, there are
97,220 new cases of colon cancer were diagnosed in 2018. The lifetime risk of developing colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
In finding a potential compound for the prevention and treatment of diseases associated with oxidative stress, researchers examined the antioxidant activity of Angelica dahurica extract in the HT-29 colon cancer cell line.
According to the A HPLC-DAD analysis, the antioxidant anti-cancer activity of the extract was attributed to the phytochemicals Imperatorin and isoimperatorin, the major coumarins in the ethanol-ethyl acetate active fraction.
In other words, Angelica dahurica extract exerted the antioxidant cancer effect by activating the pro-apoptotic proteins caspase cascade and cell cycle arrest and inhibiting the proteins associated with anti-apoptotic expressions
Based on the results, researchers said, "the ant-cancer activity of the organic extract of Angelica dahurica Radix against colon cancer cells".
Taken together, Herbal Angelica consists of the ethanol-ethyl acetate active fraction may be considered a functional herbal medicine for improving antioxidant activity against colon cancer, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-oxidant and anti-cancer activities of Angelica dahurica extract via induction of apoptosis in colon cancer cells by Zheng YM1, Shen JZ2, Wang Y2, Lu AX2, Ho WS. (PubMed)
Antimigraine
(1) Chemical Composition and Antimigraine Activity of Essential Oil of Angelicae dahuricae Radix. by Sun J1, Li H2, Sun J2, Liu H3, Chen J2, Wang C. (PubMed)
Antioxidants are stable atoms produced either by the host body or intake of dietary antioxidants-rich food with the function that inhibits oxidation caused by free radicals.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily donate or steal an electron from other molecules, leading to the chain of domino effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer by inducing the alternation of lipids, proteins, and cell DNA damage.
Colon cancer is relatively very common and slowly growing and progressing in a predictable way.
Most cases of primary colon cancer start in the cells on the surface of the inner lining of the colon. At the early stage. most patients with colon cancer do not experience any symptoms.
However, at the advanced stage, the tumor not only can spread to other healthy tissues and organs a distance away through blood and fluid circulation but also suppress the nearby tissue and nerve cells.
The progression of colon cancer at this stage not only induces symptoms of the change in bowel habits, the change in the consistency of your stool, that lasts longer than four weeks but also causes rectal bleeding and persistent abdominal severe pain.
According to the statistics by the American Cancer Society, in the US, there are
97,220 new cases of colon cancer were diagnosed in 2018. The lifetime risk of developing colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
In finding a potential compound for the prevention and treatment of diseases associated with oxidative stress, researchers examined the antioxidant activity of Angelica dahurica extract in the HT-29 colon cancer cell line.
According to the A HPLC-DAD analysis, the antioxidant anti-cancer activity of the extract was attributed to the phytochemicals Imperatorin and isoimperatorin, the major coumarins in the ethanol-ethyl acetate active fraction.
In other words, Angelica dahurica extract exerted the antioxidant cancer effect by activating the pro-apoptotic proteins caspase cascade and cell cycle arrest and inhibiting the proteins associated with anti-apoptotic expressions
Based on the results, researchers said, "the ant-cancer activity of the organic extract of Angelica dahurica Radix against colon cancer cells".
Taken together, Herbal Angelica consists of the ethanol-ethyl acetate active fraction may be considered a functional herbal medicine for improving antioxidant activity against colon cancer, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-oxidant and anti-cancer activities of Angelica dahurica extract via induction of apoptosis in colon cancer cells by Zheng YM1, Shen JZ2, Wang Y2, Lu AX2, Ho WS. (PubMed)
Antimigraine
(1) Chemical Composition and Antimigraine Activity of Essential Oil of Angelicae dahuricae Radix. by Sun J1, Li H2, Sun J2, Liu H3, Chen J2, Wang C. (PubMed)
#Tomato's Phytochemical Polyphenols In the Promotion of #Guthealth, Reserachers Say
Kyle J. Norton
Gut Microbiota is a community of microorganisms living in the gastrointestinal tract.
Under normal conditions, gut microbiota plays a critical role in overall health, including the impacts of
* In nutrient metabolism, gut microbiota improves the absorption of dietary nutrients in the digestive system
* In xenobiotic and drug metabolism, gut microbiota protects the body against xenobiotics and drug toxicity by facilitating the excretion.
* Maintenance of the structural integrity of the gut mucosal barrier, gut microbiota enhances the epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of the intestine in nutrient adsorption.
* In immunomodulation, gut microbiota interact with the immune system against inflammatory immune disorders and inhibit the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
However, an imbalanced ratio of gut microbiota may have a negative on human health and diseases.
Dr. Yu-Jie Zhang wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function".
, "However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for enhancing the ratio of dut microbiota composition researchers examined the effect of consuming tomato products and lycopene on chronic inflammatory disorders associated with intestinal bacteria in an animal model.
The study included Winnie mice as a model of spontaneous ulcerative colitis treated with or without chow enriched with 1% Bronze tomato.
At week 2, the Bronze-enriched chow-treated group showed no macroscopic effect on the IBD symptoms.
However, levels of pro-inflammatory cytokines found in the treated mice were significantly reduced, as observed by the levels of IL17A and IFNγ.
According to the analysis of the microbial composition, two weeks of Bronze enriched diet demonstrated a strong effect in the improvement of the gut microbiota ratio in the tested mice.
In additional differentiation of the results, researchers found that the efficacy of Bronze tomato in the promotion of gut health was attributed to the phytochemical polyphenols presented in the tomato.
Taken together, tomatoes processed with a high amount of lycopene may be considered a dietary supplement for gut health, pending to large sample size and multicenter human study.
Intake of polyphenols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)
(2) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions.
Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(3) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang,1 Sha Li,2 Ren-You Gan,3 Tong Zhou,1 Dong-Ping Xu,1 and Hua-Bin Li. (PMC)
Gut Microbiota is a community of microorganisms living in the gastrointestinal tract.
Under normal conditions, gut microbiota plays a critical role in overall health, including the impacts of
* In nutrient metabolism, gut microbiota improves the absorption of dietary nutrients in the digestive system
* In xenobiotic and drug metabolism, gut microbiota protects the body against xenobiotics and drug toxicity by facilitating the excretion.
* Maintenance of the structural integrity of the gut mucosal barrier, gut microbiota enhances the epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of the intestine in nutrient adsorption.
* In immunomodulation, gut microbiota interact with the immune system against inflammatory immune disorders and inhibit the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
However, an imbalanced ratio of gut microbiota may have a negative on human health and diseases.
Dr. Yu-Jie Zhang wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function".
, "However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for enhancing the ratio of dut microbiota composition researchers examined the effect of consuming tomato products and lycopene on chronic inflammatory disorders associated with intestinal bacteria in an animal model.
The study included Winnie mice as a model of spontaneous ulcerative colitis treated with or without chow enriched with 1% Bronze tomato.
At week 2, the Bronze-enriched chow-treated group showed no macroscopic effect on the IBD symptoms.
However, levels of pro-inflammatory cytokines found in the treated mice were significantly reduced, as observed by the levels of IL17A and IFNγ.
According to the analysis of the microbial composition, two weeks of Bronze enriched diet demonstrated a strong effect in the improvement of the gut microbiota ratio in the tested mice.
In additional differentiation of the results, researchers found that the efficacy of Bronze tomato in the promotion of gut health was attributed to the phytochemical polyphenols presented in the tomato.
Taken together, tomatoes processed with a high amount of lycopene may be considered a dietary supplement for gut health, pending to large sample size and multicenter human study.
Intake of polyphenols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)
(2) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions.
Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(3) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang,1 Sha Li,2 Ren-You Gan,3 Tong Zhou,1 Dong-Ping Xu,1 and Hua-Bin Li. (PMC)
Subscribe to:
Posts (Atom)