Kyle J. Norton
Cytotoxicity is the process of the induction of cell death through toxins.
In other words, cell cytotoxicity is the process to use certain chemicals or mediator cells to destroy living cells.
In normal, cytotoxicity can cause the death of healthy cells
In cancers, cytotoxicity can be beneficial to humans by destroying the cancer cells and preventing them from proliferation.
For example, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid, and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.
However, stimulation of ROS and antioxidants production to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells.
Dr. Shikha Srivastava, the lead scientist in the evaluation of the antioxidant and cytotoxic properties in Quercetin, wrote, "Quercetin interacts with DNA directly, and could be one of the mechanisms for inducing apoptosis in both, cancer cell lines and tumor tissues by activating the intrinsic pathway".
And, " quercetin-induced cytotoxicity in leukemic cells in a dose-dependent manner, while ellagic acid showed only limited toxicity. Besides leukemic cells, quercetin also induced cytotoxicity in breast cancer cells, however, its effect on normal cells was limited or none".
Scientifically, most cases of cancer cells cytotoxicity are associated with the stimulation of proteins and pathways involved in either gene suppression or cell death programming.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to find a natural ingredient that kills cancer without inducing adverse effects, researchers examined the toxicity against human gastric adenocarcinoma cells (AGS) and the antioxidant activity of hydroethanolic (HME), acetone (AcE), an alkaloid (AE) extracts prepared from the leaves of the tomato plant.
Both HME and AcE extracts showed a significant effect in scavenging •NO (IC50 values ranged from 0.87 ± 0.12 to 1.54 ± 0.23 and from 0.90 ± 0.01 to 2.23 ± 0.14 mg mL-1, respectively), compared to HMEs that only scavenge O2•- showing IC50 values from 0.12 ± ≤0.01 to 0.43 ± 0.08 mg mL-1.
In other words, tomato extracts demonstrated a strong effect against human gastric adenocarcinoma cells (AGS) through their cytotoxicity without causing harm to normal cells through the antioxidant activity.
Furthermore, in the study to assess different varieties of tomato seed extracts potential antioxidant and/or antiproliferative activity, researchers found that San Marzano Rosso seed extract displays the highest free radical-scavenging activity with 68% of 2,2-Diphenyl-1-picrylhydrazyl radical inhibition.
Moreover, according to the brine shrimp test (LD50: 23,198 ppm), San Marzano Rosso seed extract also demonstrated the highest cytotoxicity against the A375 cell line, compared to other varieties.
Taken altogether, tomato and its leaves may be considered supplements for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of tomato in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Further insights on tomato plant: Cytotoxic and antioxidant activity of leaf extracts in human gastric cells by Figueiredo-González M1, Valentão P1, Pereira DM1, Andrade PB. (PubMed)
(2) Antioxidant and cytotoxic activities investigation of tomato seed extracts by Tommonaro G1, Caporale A, De Martino L, Popolo A, De Prisco R, Nicolaus B, Abbamondi GR, Saturnino C. (PubMed)
(3) Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell. Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis by Shikha Srivastava, Ranganatha R. Somasagara, Mahesh Hegde, Mayilaadumveettil Nishana, Satish Kumar Tadi, Mrinal Srivastava, Bibha Choudhary & Sathees C. Raghavan. (Scientific Report)
Saturday, 26 August 2023
#Healthfood #Tomato's #Lycopene Inhibits #Oxidativestress Associated with a Reduced Risk of #OvarianCancer, Scientists Show
Kyle J. Norton
Ovarian cancer is a medical condition caused by irregular cell growth in the lining tissues of the ovary.
Most cases of ovarian cancer begin in the cells on the surface of the inner lining of the ovary tissue before penetrating into deeper layers and colonizing the entire organ to induce secondary metastasis through blood and fluid circulation.
Ovarian cancer can be divided into the types below
* Epithelial Ovarian Cancer
The epithelial ovarian tumor also is known as a surface epithelial-stromal tumor, caused by the alternation of DNA of the cell on the surface of the ovary. Epithelial ovarian tumor is the most common form of ovarian cancer accounting for over 90% of all cases, including serious tumors, endometrioid tumors, and mucinous cystadenocarcinoma.
* Germ cell ovarian cancer
Germ cell ovarian tumor is a cancer of the egg-producing cells within the ovary and can be cancerous or non-cancerous tumors. The condition tends to occur in children and teens as a result of birth defects.
* Sex cord-stromal ovarian cancer
Sex cord-stromal ovarian tumor is a cancer of the tissue of the ovary that accounts for 8% of ovarian cancers. It is believed that the cancer is caused by excess estrogen produced by sex cord-stromal ovarian tumors. Sex cord-stromal ovarian cancer tends to develop in the older age group.
The most common symptoms of ovarian cancer are abdominal pain, bloating or swelling, quickly feeling full when eating, discomfort in the pelvis area, and change of bowel movement accompanied by the general symptoms shared by other cancers, such as unintended weight loss, gastrointestinal discomfort, loss of appetite and persistent fatigue.
Some researchers suggested that the widespread obesity caused by the promotion of a high-fat diet in the Western world may correlate to the increased risk of ovarian cancer.
Dr. Foong KW, wrote, " " 14 studies found a statistically significant positive association between ovarian cancer risk and higher body mass index, 26 studies found no significant association, and 3 studies found a negative association between ovarian cancer risk and higher body mass index".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of ovarian cancer, researchers investigated the combined effect of reduced graphene oxide-silver nanoparticles (rGO-AgNPs, with biomolecule called lycopene,) and trichostatin A (TSA) in human ovarian cancer cells (SKOV3).
According to the tested assays, AgNPs uniformly distributed on the surface of the graphene sheet with an average size between 10 and 50 nm, rGO-Ag, and TSA demonstrated significant inhibition of the cell viability in a dose-dependent manner.
At low concentrations, the combination of rGO-Ag and TSA not only had a significant effect on cell viability, and increased cytotoxicity but also inhibited the level of malondialdehyde (oxidative stress) and decreased the level of glutathione (antioxidants) that induced cancer cell mitochondrial dysfunction.
Based on the findings, researchers suggested, " This combination chemotherapy could be possibly used in advanced cancers that are not suitable for radiation therapy or surgical treatment and facilitate overcoming tumor resistance and disease progression".
Furthermore, the combination of rGO-Ag and TSA-induced cancer cell apoptosis was attributed to their pronounced effect on DNA fragmentation and double-strand breaks.
In order to reveal more information about lycopene, and anti-ovarian cancer activity scientists examined the protective role of dietary lycopene against the risk of ovarian cancer.
The search of the meta-analysis. identified 10 studies selected from the PubMed database, and final risk estimates, using a random-effects model showed that lycopene showed an effect on the risk of ovarian cancer among postmenopausal women, compared to an insignificant reverse association between dietary lycopene and ovarian cancer risk to other groups.
In other words, rGO-AgNPs, with a biomolecule called lycopene, are effective in reducing the risk and treatment of ovarian cancer in all groups compared to dietary lycopene in postmenopausal women.
Taken altogether, tomatoes processed with abundantly bioactive compound lycopene may be considered supplements for the prevention and treatment of ovarian cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances the apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3) b yZhang XF1,2, Huang FH1, Zhang GL3, Bai DP4, Massimo DF5, Huang YF4, Gurunathan S. (PubMed)
(2) Meta-analysis of the association between dietary lycopene intake and ovarian cancer risk in postmenopausal women by Li X1, Xu J. (PubMed)
(3) Obesity and ovarian cancer risk: A systematic review by Foong KW1, Bolton H. (PubMed)
Ovarian cancer is a medical condition caused by irregular cell growth in the lining tissues of the ovary.
Most cases of ovarian cancer begin in the cells on the surface of the inner lining of the ovary tissue before penetrating into deeper layers and colonizing the entire organ to induce secondary metastasis through blood and fluid circulation.
Ovarian cancer can be divided into the types below
* Epithelial Ovarian Cancer
The epithelial ovarian tumor also is known as a surface epithelial-stromal tumor, caused by the alternation of DNA of the cell on the surface of the ovary. Epithelial ovarian tumor is the most common form of ovarian cancer accounting for over 90% of all cases, including serious tumors, endometrioid tumors, and mucinous cystadenocarcinoma.
* Germ cell ovarian cancer
Germ cell ovarian tumor is a cancer of the egg-producing cells within the ovary and can be cancerous or non-cancerous tumors. The condition tends to occur in children and teens as a result of birth defects.
* Sex cord-stromal ovarian cancer
Sex cord-stromal ovarian tumor is a cancer of the tissue of the ovary that accounts for 8% of ovarian cancers. It is believed that the cancer is caused by excess estrogen produced by sex cord-stromal ovarian tumors. Sex cord-stromal ovarian cancer tends to develop in the older age group.
The most common symptoms of ovarian cancer are abdominal pain, bloating or swelling, quickly feeling full when eating, discomfort in the pelvis area, and change of bowel movement accompanied by the general symptoms shared by other cancers, such as unintended weight loss, gastrointestinal discomfort, loss of appetite and persistent fatigue.
Some researchers suggested that the widespread obesity caused by the promotion of a high-fat diet in the Western world may correlate to the increased risk of ovarian cancer.
Dr. Foong KW, wrote, " " 14 studies found a statistically significant positive association between ovarian cancer risk and higher body mass index, 26 studies found no significant association, and 3 studies found a negative association between ovarian cancer risk and higher body mass index".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of ovarian cancer, researchers investigated the combined effect of reduced graphene oxide-silver nanoparticles (rGO-AgNPs, with biomolecule called lycopene,) and trichostatin A (TSA) in human ovarian cancer cells (SKOV3).
According to the tested assays, AgNPs uniformly distributed on the surface of the graphene sheet with an average size between 10 and 50 nm, rGO-Ag, and TSA demonstrated significant inhibition of the cell viability in a dose-dependent manner.
At low concentrations, the combination of rGO-Ag and TSA not only had a significant effect on cell viability, and increased cytotoxicity but also inhibited the level of malondialdehyde (oxidative stress) and decreased the level of glutathione (antioxidants) that induced cancer cell mitochondrial dysfunction.
Based on the findings, researchers suggested, " This combination chemotherapy could be possibly used in advanced cancers that are not suitable for radiation therapy or surgical treatment and facilitate overcoming tumor resistance and disease progression".
Furthermore, the combination of rGO-Ag and TSA-induced cancer cell apoptosis was attributed to their pronounced effect on DNA fragmentation and double-strand breaks.
In order to reveal more information about lycopene, and anti-ovarian cancer activity scientists examined the protective role of dietary lycopene against the risk of ovarian cancer.
The search of the meta-analysis. identified 10 studies selected from the PubMed database, and final risk estimates, using a random-effects model showed that lycopene showed an effect on the risk of ovarian cancer among postmenopausal women, compared to an insignificant reverse association between dietary lycopene and ovarian cancer risk to other groups.
In other words, rGO-AgNPs, with a biomolecule called lycopene, are effective in reducing the risk and treatment of ovarian cancer in all groups compared to dietary lycopene in postmenopausal women.
Taken altogether, tomatoes processed with abundantly bioactive compound lycopene may be considered supplements for the prevention and treatment of ovarian cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances the apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3) b yZhang XF1,2, Huang FH1, Zhang GL3, Bai DP4, Massimo DF5, Huang YF4, Gurunathan S. (PubMed)
(2) Meta-analysis of the association between dietary lycopene intake and ovarian cancer risk in postmenopausal women by Li X1, Xu J. (PubMed)
(3) Obesity and ovarian cancer risk: A systematic review by Foong KW1, Bolton H. (PubMed)
#Curcumin Isolated from #Turmeric Inhibits #EndometrialCancer Cell Migration, Proliferation and Invasion, According to Studies
Kyle J. Norton
Cancer is a group of chronic diseases characterized by cell growth disorderly and uncontrollably in the body tissue of a specific organ.
Over time, after growing in size through unlimited division, the tumor can spread to other tissues and organs in the body via lymph or blood.
Endometrium, the inner lining of women's uterus is very susceptible to hormone change, particularly in the stages of the menstrual cycle.
Endometrial cancer is a late adulthood cancer that starts in the cells on the surface of the endometrial inner lining of the uterus caused by the alternation of the cell's DNA. Endometrial cancer is the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
In the US, according to statistics, the average age of women diagnosed with endometrial cancer is 60. Endometrial cancer is more common in white women, but black women diagnosed with endometrial cancer are more likely to die from it.
There are more than 600,000 women endometrial cancer survivors in the US today. In 2019, approximately 61,880 new cases of cancer in the uterus (uterine body or corpus) will be diagnosed and this cancer will cause the death of 12,160 women.
Accompanied by the general symptoms shared by other types of cancer, the most common symptoms of endometrial cancer are
* Abnormal vaginal bleeding
Vaginal bleeding during the period with inappropriate amounts of blood flow should be checked with the doctor as soon as possible. The symptom may be caused by the expansion of overgrowth of pre-cancer uterine lining cells due to infection or breaking off the endometrial capillaries or blood vessels.
* Increase the amount of vaginal discharge
An increase in the amount of vaginal discharge accompanied by abnormal odor or pain, itching, or burning sensation may be caused by infection or inflammation.
* Painful urination
Painful urination, most of the time is caused by infection of the urinary tract that affects the bladder in emptying, but sometimes it can be caused by infectious diseases.
* Pain during sex
Painful during Most of the time is caused by vestibulitis and vaginismus sex, but in some cases, it can be caused by cancer or other reproductive diseases.
* Pain in the abdomen
There are many reproductive diseases that can cause pain in the pelvis, such as appendicitis, salpingitis, uterine descensus,.. but it can be caused by the early stage of endometrial cancer.
* Swelling or lump in the pelvis
Swelling can be caused by inflammation of sexually transmitted viruses or infection by bacteria. The lump may be caused by abnormal cell growth of the uterine lining or reproductive tissue.
*Anemia
Anemia may be caused by chronic loss of blood due to prolonged or heavy abnormal menstrual bleeding.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In finding a potential ingredient for the treatment of endometrial cancer, researchers examined the anti-metastatic effect and molecular mechanism of curcumin in endometrial carcinoma (ECd ) of curcumin isolated from turmeric.
According to the assays carried out in EC cell lines,
*In vitro, curcumin inhibited EC cell migration and invasion.
* Curcumin treatment for 24 hours, decreased the expression levels of matrix metalloproteinase (MMP)-2 and -9 associated with cancer cell proliferation and survival.
* Furthermore curcumin for 24 hours of treatment also inhibited the protease activities associated with metastatic potential in EC cell lines.
* Curcumin treatment exerted anti-metastatic effects by blocking the overexpression of pathways involved in cancer cell growth.
* Moreover, combined with chemo drug ERK inhibitor U0126, curcumin works synergistically against enzymes associated with tumor proliferation, particularly, in the inhibition of the invasive capabilities of HEC-1B cells.
More precisely, curcumin inhibits tumor cell migration and invasion by reducing the expression and activity of MMP-2/9 associated with tumors proliferation via the suppression of the ERK signaling pathway in stimulating cancer cell growth.
Based on the findings and after taking other factors into account, Dr. QIAN CHEN, the lead scientist wrote in the final report, "Curcumin is a potential therapeutic agent for EC".
Taken altogether, turmeric-processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of endometrial cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin suppresses migration and invasion of human endometrial carcinoma cells by QIAN CHEN,1,* QING GAO,1 KUNLUN CHEN,1 YIDONG WANG,1 LIJUAN CHEN,1 and XU LI. (PMC)
(2)
Cancer of Endometrium/Endometrial Cancer by Kyle J. Norton
Cancer is a group of chronic diseases characterized by cell growth disorderly and uncontrollably in the body tissue of a specific organ.
Over time, after growing in size through unlimited division, the tumor can spread to other tissues and organs in the body via lymph or blood.
Endometrium, the inner lining of women's uterus is very susceptible to hormone change, particularly in the stages of the menstrual cycle.
Endometrial cancer is a late adulthood cancer that starts in the cells on the surface of the endometrial inner lining of the uterus caused by the alternation of the cell's DNA. Endometrial cancer is the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
In the US, according to statistics, the average age of women diagnosed with endometrial cancer is 60. Endometrial cancer is more common in white women, but black women diagnosed with endometrial cancer are more likely to die from it.
There are more than 600,000 women endometrial cancer survivors in the US today. In 2019, approximately 61,880 new cases of cancer in the uterus (uterine body or corpus) will be diagnosed and this cancer will cause the death of 12,160 women.
Accompanied by the general symptoms shared by other types of cancer, the most common symptoms of endometrial cancer are
* Abnormal vaginal bleeding
Vaginal bleeding during the period with inappropriate amounts of blood flow should be checked with the doctor as soon as possible. The symptom may be caused by the expansion of overgrowth of pre-cancer uterine lining cells due to infection or breaking off the endometrial capillaries or blood vessels.
* Increase the amount of vaginal discharge
An increase in the amount of vaginal discharge accompanied by abnormal odor or pain, itching, or burning sensation may be caused by infection or inflammation.
* Painful urination
Painful urination, most of the time is caused by infection of the urinary tract that affects the bladder in emptying, but sometimes it can be caused by infectious diseases.
* Pain during sex
Painful during Most of the time is caused by vestibulitis and vaginismus sex, but in some cases, it can be caused by cancer or other reproductive diseases.
* Pain in the abdomen
There are many reproductive diseases that can cause pain in the pelvis, such as appendicitis, salpingitis, uterine descensus,.. but it can be caused by the early stage of endometrial cancer.
* Swelling or lump in the pelvis
Swelling can be caused by inflammation of sexually transmitted viruses or infection by bacteria. The lump may be caused by abnormal cell growth of the uterine lining or reproductive tissue.
*Anemia
Anemia may be caused by chronic loss of blood due to prolonged or heavy abnormal menstrual bleeding.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In finding a potential ingredient for the treatment of endometrial cancer, researchers examined the anti-metastatic effect and molecular mechanism of curcumin in endometrial carcinoma (ECd ) of curcumin isolated from turmeric.
According to the assays carried out in EC cell lines,
*In vitro, curcumin inhibited EC cell migration and invasion.
* Curcumin treatment for 24 hours, decreased the expression levels of matrix metalloproteinase (MMP)-2 and -9 associated with cancer cell proliferation and survival.
* Furthermore curcumin for 24 hours of treatment also inhibited the protease activities associated with metastatic potential in EC cell lines.
* Curcumin treatment exerted anti-metastatic effects by blocking the overexpression of pathways involved in cancer cell growth.
* Moreover, combined with chemo drug ERK inhibitor U0126, curcumin works synergistically against enzymes associated with tumor proliferation, particularly, in the inhibition of the invasive capabilities of HEC-1B cells.
More precisely, curcumin inhibits tumor cell migration and invasion by reducing the expression and activity of MMP-2/9 associated with tumors proliferation via the suppression of the ERK signaling pathway in stimulating cancer cell growth.
Based on the findings and after taking other factors into account, Dr. QIAN CHEN, the lead scientist wrote in the final report, "Curcumin is a potential therapeutic agent for EC".
Taken altogether, turmeric-processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of endometrial cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin suppresses migration and invasion of human endometrial carcinoma cells by QIAN CHEN,1,* QING GAO,1 KUNLUN CHEN,1 YIDONG WANG,1 LIJUAN CHEN,1 and XU LI. (PMC)
(2)
Cancer of Endometrium/Endometrial Cancer by Kyle J. Norton
#Herbal #Ashwagandha Inhibits the Risk of #Diabetes by Protecting the Beta Cells of Pancreas and Increasing thr Antioxidant Activity, Researchers Show
Kyle J. Norton
Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream. Insulin resistance and hyperglycemia are hallmarks of diabetes.
In other words, insulin produced by the pancreas is either blocked by the clogging-up of the insulin receptors by fat and cholesterol or the death of beta cells in the pancreas. In some cases, diabetes can also be associated with autoimmune disease, attacking the beta cells.
There are some major types of diabetes, including the best known, type 1 and 2.
* Type 1 diabetes is associated with a genetic proposition that leads to the immune system to attack insulin-producing cells of the pancreas.
* Type 2 diabetes (acquired diabetes), is a condition caused by either the pancreas doesn't produce enough insulin, or the insulin does not work properly due to dysfunction of the insulin receptors.
In pregnancy, gestational diabetes is a type of diabetes occurred during the second or third trimester of pregnancy. Gestation diabetes goes away after giving birth.
However, omen with gestation diabetes is associated with a substantial risk of diabetes developing sometimes in the future.
Epidemiologically, obesity, an unhealthy lifestyle with physical inactivity are some of the most common risk factor associated with the slow onset of diabetes.
Interestingly, some researchers suggested, night shifts workers accompanied by unhealthy lifestyles are linking to a high risk of type 2 diabetes.
" risk of type 2 diabetes is actually higher than simply adding the individual risks associated with unhealthy lifestyle and shift work together, indicating that combining an unhealthy lifestyle with irregular night-time working adds a further risk".
"It is well-established that unhealthy lifestyle behaviors such as smoking, a poor diet, and little exercise, and being overweight or obese increase the risk of type 2 diabetes. Shift work, especially night shift work, has also been associated with a greater risk of type 2 diabetes".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
With an aim to find a potent compound for the treatment of diabetes, researchers examined the effects of Withania somnifera (WS) on lipid peroxidation (LPO) and pancreas in type 2 diabetic rats.
The study included type 2 diabetes induced by a single intraperitoneal injection of STZ (100 mg/kg) to 2 days old rat pups pretreated by WS.
According to the tested analysis, untreated rats group showed significant levels of lipid peroxidation (LPO) observed by reducing levels of antioxidant enzymes produced by the host including glutathione (GSH) contents and by enzymatic activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT).
However, injection of WS not only caused a significant decrease in blood glucose and tissue LPO levels caused by the application of STZ but also a significant increase in GSH contents, compared to type 2 diabetic control rats.
Furthermore, antioxidant enzymes reduced in the untreated rat such as GPx, GR, GST, SOD, and CAT were also increased compared to type 2 diabetic control rats.
Most importantly, the significant reduction in the number and size of pancreatic beta-cells in STZ rats was normalized upon the administration of WS, evident from the histopathological examination.
In other words, WS protects the cells in the pancreas against oxidation and maintains the integrity of beta cells in insulin production in type 2 diabetes rats.
Based on the findings, researchers said, "WS has shown strong free radical scavenging activity and helped in improving the non-enzymatic and enzymatic antioxidants in type 2 diabetic rats".
Taken altogether, Ashwagandha WS may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of type 2 diabetes, pending to the results of large example size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of Withania somnifera against oxidative stress and pancreatic beta-cell damage in type 2 diabetic rats by Anwer T1, Sharma M, Pillai KK, Khan G. (PubMed)
(2) Oral supplementation of standardized extract of Withania somnifera protects against diabetes-induced testicular oxidative impairments in prepubertal rats by Kyathanahalli CN1, Manjunath MJ, Muralidhara. (PubMed)
(3) Night shifts and an unhealthy lifestyle linked to high risk of type 2 diabetes by BMJ
Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream. Insulin resistance and hyperglycemia are hallmarks of diabetes.
In other words, insulin produced by the pancreas is either blocked by the clogging-up of the insulin receptors by fat and cholesterol or the death of beta cells in the pancreas. In some cases, diabetes can also be associated with autoimmune disease, attacking the beta cells.
There are some major types of diabetes, including the best known, type 1 and 2.
* Type 1 diabetes is associated with a genetic proposition that leads to the immune system to attack insulin-producing cells of the pancreas.
* Type 2 diabetes (acquired diabetes), is a condition caused by either the pancreas doesn't produce enough insulin, or the insulin does not work properly due to dysfunction of the insulin receptors.
In pregnancy, gestational diabetes is a type of diabetes occurred during the second or third trimester of pregnancy. Gestation diabetes goes away after giving birth.
However, omen with gestation diabetes is associated with a substantial risk of diabetes developing sometimes in the future.
Epidemiologically, obesity, an unhealthy lifestyle with physical inactivity are some of the most common risk factor associated with the slow onset of diabetes.
Interestingly, some researchers suggested, night shifts workers accompanied by unhealthy lifestyles are linking to a high risk of type 2 diabetes.
" risk of type 2 diabetes is actually higher than simply adding the individual risks associated with unhealthy lifestyle and shift work together, indicating that combining an unhealthy lifestyle with irregular night-time working adds a further risk".
"It is well-established that unhealthy lifestyle behaviors such as smoking, a poor diet, and little exercise, and being overweight or obese increase the risk of type 2 diabetes. Shift work, especially night shift work, has also been associated with a greater risk of type 2 diabetes".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
With an aim to find a potent compound for the treatment of diabetes, researchers examined the effects of Withania somnifera (WS) on lipid peroxidation (LPO) and pancreas in type 2 diabetic rats.
The study included type 2 diabetes induced by a single intraperitoneal injection of STZ (100 mg/kg) to 2 days old rat pups pretreated by WS.
According to the tested analysis, untreated rats group showed significant levels of lipid peroxidation (LPO) observed by reducing levels of antioxidant enzymes produced by the host including glutathione (GSH) contents and by enzymatic activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT).
However, injection of WS not only caused a significant decrease in blood glucose and tissue LPO levels caused by the application of STZ but also a significant increase in GSH contents, compared to type 2 diabetic control rats.
Furthermore, antioxidant enzymes reduced in the untreated rat such as GPx, GR, GST, SOD, and CAT were also increased compared to type 2 diabetic control rats.
Most importantly, the significant reduction in the number and size of pancreatic beta-cells in STZ rats was normalized upon the administration of WS, evident from the histopathological examination.
In other words, WS protects the cells in the pancreas against oxidation and maintains the integrity of beta cells in insulin production in type 2 diabetes rats.
Based on the findings, researchers said, "WS has shown strong free radical scavenging activity and helped in improving the non-enzymatic and enzymatic antioxidants in type 2 diabetic rats".
Taken altogether, Ashwagandha WS may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of type 2 diabetes, pending to the results of large example size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of Withania somnifera against oxidative stress and pancreatic beta-cell damage in type 2 diabetic rats by Anwer T1, Sharma M, Pillai KK, Khan G. (PubMed)
(2) Oral supplementation of standardized extract of Withania somnifera protects against diabetes-induced testicular oxidative impairments in prepubertal rats by Kyathanahalli CN1, Manjunath MJ, Muralidhara. (PubMed)
(3) Night shifts and an unhealthy lifestyle linked to high risk of type 2 diabetes by BMJ
#WhiteCabbage #Essentialoil (EO) Inhibits Oxidativestress Against Liver Injury, According to Studies
Kyle J. Norton
The liver is the largest internal organ in the human body, and plays an essential role in filtering blood from the intestine before passing it to other parts of the body.
The organ also produces cholesterol, a waxy substance that is needed to aid digestion and build strong cell membranes, production of steroid hormones, and vitamins.
Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.
Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases. surgery to stop the bleeding and remove the part of the injury may be necessary.
According to the statistics, liver injury has been found to constitute 5% of all traumas, making it the most common abdominal injury.
Other most common symptoms associated with liver injury are shocks due to severe bleeding inducing a rapid heart rate, rapid breathing, and cold, clammy, pale, or bluish skin.
In some cases, blood accumulated in the abdomen may irritate the abdominal tissue, leading to symptoms of abdominal pain swelling, and tenderness.
The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.
Depending on the size of the wound, most cases of liver injury are healed by themselves. However, in severe cases, hospitalization may be necessary if the bleeding does not stop.
The most common cause of liver injury is an overdose of medicine which has been found to be the number 1 factor.
Cabbage is a species of Brassica oleracea belonging to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.
In finding a natural whole for the improvement of liver diseases, researchers examined the hepatoprotective properties of the essential oil (EO) from white cabbage.
In acute carbon tetrachloride (CT)-induced liver damage,
* Bocfal EO contained organic polysulphides (OPSs), such as dimethyl trisulphide (DMTS) 65.43 ± 4.92% and dimethyl disulfidefood (DMDS) 19.29 ± 2.16% as major constituents.
* Bocfal EO and DMTS were found to be potent TBARS, a byproduct of lipid peroxidation inhibitors with IC50 values of 0.51 and 3 mg/L, respectively.
* Bocfal EO demonstrated better hepatoprotective properties than did DADS (p < 0.05), although both slightly affected the hepatic parenchyma per se.
Based on the findings, researchers said, "The antioxidant properties of Bocfal EO and DMTS may be the mechanism of hepatoprotective action; the parenchymal disturbances by Bocfal EO or DADS alone may be related to the high doses used".
Taken altogether, cabbage process anti-liver injury, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of antioxidant and hepatoprotective effects of white cabbage essential oil by Morales-López J1, Centeno-Álvarez M2, Nieto-Camacho A3, López MG4, Pérez-Hernández E5, Pérez-Hernández N1, Fernández-Martínez E. (PubMed).
The liver is the largest internal organ in the human body, and plays an essential role in filtering blood from the intestine before passing it to other parts of the body.
The organ also produces cholesterol, a waxy substance that is needed to aid digestion and build strong cell membranes, production of steroid hormones, and vitamins.
Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.
Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases. surgery to stop the bleeding and remove the part of the injury may be necessary.
According to the statistics, liver injury has been found to constitute 5% of all traumas, making it the most common abdominal injury.
Other most common symptoms associated with liver injury are shocks due to severe bleeding inducing a rapid heart rate, rapid breathing, and cold, clammy, pale, or bluish skin.
In some cases, blood accumulated in the abdomen may irritate the abdominal tissue, leading to symptoms of abdominal pain swelling, and tenderness.
The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.
Depending on the size of the wound, most cases of liver injury are healed by themselves. However, in severe cases, hospitalization may be necessary if the bleeding does not stop.
The most common cause of liver injury is an overdose of medicine which has been found to be the number 1 factor.
Cabbage is a species of Brassica oleracea belonging to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.
In finding a natural whole for the improvement of liver diseases, researchers examined the hepatoprotective properties of the essential oil (EO) from white cabbage.
In acute carbon tetrachloride (CT)-induced liver damage,
* Bocfal EO contained organic polysulphides (OPSs), such as dimethyl trisulphide (DMTS) 65.43 ± 4.92% and dimethyl disulfidefood (DMDS) 19.29 ± 2.16% as major constituents.
* Bocfal EO and DMTS were found to be potent TBARS, a byproduct of lipid peroxidation inhibitors with IC50 values of 0.51 and 3 mg/L, respectively.
* Bocfal EO demonstrated better hepatoprotective properties than did DADS (p < 0.05), although both slightly affected the hepatic parenchyma per se.
Based on the findings, researchers said, "The antioxidant properties of Bocfal EO and DMTS may be the mechanism of hepatoprotective action; the parenchymal disturbances by Bocfal EO or DADS alone may be related to the high doses used".
Taken altogether, cabbage process anti-liver injury, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of antioxidant and hepatoprotective effects of white cabbage essential oil by Morales-López J1, Centeno-Álvarez M2, Nieto-Camacho A3, López MG4, Pérez-Hernández E5, Pérez-Hernández N1, Fernández-Martínez E. (PubMed).
#Lycopene Normalizes the LiverWeight, Hepatic TC, and Serum LDL in Non Alcoholic Fatty Liver Disease Patients, Researchers Find
Kyle J. Norton
The liver is the largest internal and detoxed organ which not only cleanses the blood from the intestinal tract before passing the blood to nourish other tissues and organs in the body but also secrets bile to aid digestion, build strong cell membranes, and produces vitamin D, and steroid hormones.
Additionally, antioxidant enzymes produced by the liver that inhibit free radicals oxidation also play an essential role in reducing the risk of oxidative stress, the major cause of protein, lipid, and cellular damage.
Liver disease is a class of health problems that cause the reduced function of the liver.
Nonalcoholic fatty liver disease (NAFLD) is a chronic condition induced by the onset of cirrhosis and liver cancer caused by fat accumulated in the liver over time, with no influence of excessive alcohol use. The disease can be classified into the types of non-inflammatory fatty liver (NAFL) and inflammatory nonalcoholic steatohepatitis (NASH).
Cirrhosis, in the late stage of liver scarring, as the liver tries to heal itself by halting inflammation, inducing symptoms of ascites, swell esophageal varices, hepatic encephalopathy, complications of liver cancer, and liver failure.
According to the statistics provided by the American Liver Association, in the US about 100 million Americans are living with Non-Alcoholic Fatty Liver Disease.
Believe it or not, non-Alcoholic Fatty Liver Disease (NAFLD), is also the most common form of liver disease in children and has more than doubled over the past 20 years.
The 2016 joint study led by the Autonomous University of Queretaro, showed that lycopene (LYC) may be effective on a nonalcoholic fatty liver disease (NAFLD) model induced with a high-fat diet (HFD).
Some researchers suggested that the increased incidence of non-alcoholic fatty liver disease (NAFLD) in Americans that causes the onset of obesity may be correlated with the promotion of a high-fat diet.
Dr. Jensen VS, the lead scientist said, "In humans and animal models, excessive intake of dietary fat, fructose, and cholesterol have been linked to the development of non-alcoholic fatty liver disease (NAFLD)".
And, "dietary fat and cholesterol are the primary drivers of NAFLD development and progression in rats, while fructose mostly exerts its effect on the circulating lipid pool".
Sprague-Dawley rats selected for the study induced an NAFLD model by either a normal diet (ND·4w) or an HFD (HFD·4w) during 4 weeks
Then, rats from the ND·4w group continued for 4 weeks with the same diet (ND·8w), and rats from HFD were fed during 4 weeks with an ND (HFD·4w+ND·4w) or an ND plus LYC (HFD·4w+ND+LYC·4w).
Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
Based on the tested analysis, ND plus LYC showed a significant effect on NAFLD observed by the normalizing liver weight, hepatic TC, and serum LDL.
Additionally, the ND plus LYC fed group demonstrated the reversal of some macroscopic and microscopic images of livers.
However, lycopene failed to inhibit the liver stress markers such as malondialdehyde level and serum aspartate aminotransferase activity during the period of study.
Dr. Piña-Zentella RM, the lead scientist after taking other factors into account wrote, "The results from this study suggest the potentially protective role of LYC against NAFLD".
Taken altogether, lycopene found in tomato may be considered a supplement for the prevention and treatment of Nonalcoholic Fatty Liver Disease, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene Improves Diet-Mediated Recuperation in Rat Model of Nonalcoholic Fatty Liver Disease by Piña-Zentella RM1, Rosado JL1, Gallegos-Corona MA2, Madrigal-Pérez LA3, García OP1, Ramos-Gomez M. (PubMed).
The liver is the largest internal and detoxed organ which not only cleanses the blood from the intestinal tract before passing the blood to nourish other tissues and organs in the body but also secrets bile to aid digestion, build strong cell membranes, and produces vitamin D, and steroid hormones.
Additionally, antioxidant enzymes produced by the liver that inhibit free radicals oxidation also play an essential role in reducing the risk of oxidative stress, the major cause of protein, lipid, and cellular damage.
Liver disease is a class of health problems that cause the reduced function of the liver.
Nonalcoholic fatty liver disease (NAFLD) is a chronic condition induced by the onset of cirrhosis and liver cancer caused by fat accumulated in the liver over time, with no influence of excessive alcohol use. The disease can be classified into the types of non-inflammatory fatty liver (NAFL) and inflammatory nonalcoholic steatohepatitis (NASH).
Cirrhosis, in the late stage of liver scarring, as the liver tries to heal itself by halting inflammation, inducing symptoms of ascites, swell esophageal varices, hepatic encephalopathy, complications of liver cancer, and liver failure.
According to the statistics provided by the American Liver Association, in the US about 100 million Americans are living with Non-Alcoholic Fatty Liver Disease.
Believe it or not, non-Alcoholic Fatty Liver Disease (NAFLD), is also the most common form of liver disease in children and has more than doubled over the past 20 years.
The 2016 joint study led by the Autonomous University of Queretaro, showed that lycopene (LYC) may be effective on a nonalcoholic fatty liver disease (NAFLD) model induced with a high-fat diet (HFD).
Some researchers suggested that the increased incidence of non-alcoholic fatty liver disease (NAFLD) in Americans that causes the onset of obesity may be correlated with the promotion of a high-fat diet.
Dr. Jensen VS, the lead scientist said, "In humans and animal models, excessive intake of dietary fat, fructose, and cholesterol have been linked to the development of non-alcoholic fatty liver disease (NAFLD)".
And, "dietary fat and cholesterol are the primary drivers of NAFLD development and progression in rats, while fructose mostly exerts its effect on the circulating lipid pool".
Sprague-Dawley rats selected for the study induced an NAFLD model by either a normal diet (ND·4w) or an HFD (HFD·4w) during 4 weeks
Then, rats from the ND·4w group continued for 4 weeks with the same diet (ND·8w), and rats from HFD were fed during 4 weeks with an ND (HFD·4w+ND·4w) or an ND plus LYC (HFD·4w+ND+LYC·4w).
Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
Based on the tested analysis, ND plus LYC showed a significant effect on NAFLD observed by the normalizing liver weight, hepatic TC, and serum LDL.
Additionally, the ND plus LYC fed group demonstrated the reversal of some macroscopic and microscopic images of livers.
However, lycopene failed to inhibit the liver stress markers such as malondialdehyde level and serum aspartate aminotransferase activity during the period of study.
Dr. Piña-Zentella RM, the lead scientist after taking other factors into account wrote, "The results from this study suggest the potentially protective role of LYC against NAFLD".
Taken altogether, lycopene found in tomato may be considered a supplement for the prevention and treatment of Nonalcoholic Fatty Liver Disease, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene Improves Diet-Mediated Recuperation in Rat Model of Nonalcoholic Fatty Liver Disease by Piña-Zentella RM1, Rosado JL1, Gallegos-Corona MA2, Madrigal-Pérez LA3, García OP1, Ramos-Gomez M. (PubMed).
#Fennel Comibined with #AscorbicAcid Intake Daily Are Associated with a Reduced Daily Stress in the Workplaces, Scientists Suggest
Kyle J. Norton
Fennel may have a potential and positive effect in reducing stress implications, some scientists suggested.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Society and environment impact stress conditions, over a prolonged period of time, which may induce a change of behavior, leading to disturbances in normal physiological functioning due to increased free radicals generation in the initiated onset of hypertension, neurosis, immune suppression, and other physical and mental disorders.
In the study to evaluate the anti-stress and memory-enhancing properties of F. Vulgare extract in experimentally stress rats at doses of 50, 100, and 200 mg/kg body weight administered orally with an orogastric tube researchers found that rats treated with all doses exert a significant effect in reduced stress implication linearly, observed by Urinary levels of vanillylmandelic acid (VMA) assay in 24 hours.
Further analysis of the rat group treated fennel with an additional injection of ascorbic acid also found that the secretion of urinary ascorbic acid levels increased from 65.74 to 78.59, 108.41, and 125.82 μg/kg within the same period on doses of 50, 100, and 200 mg/kg body weight respectively in compared to the untreated control group.
These results indicated that fennel has a stronger impact on reduced chronic stress connotation compared to both ascorbic acid and control groups.
Moreover, the group treatment group also displayed a reduced expression of lipid peroxidation in both rat liver and brain homogenates catalyzed by the stress in induction of ROS production and reduced natural antioxidant defense compared to the rat group treated with ascorbic acid.
Dr. S Koppula,, the lead author, after taking into account other confounders said, "The (Fennel) extract also exhibited potent antioxidant effect by inhibition of lipid peroxidation in both rat liver and brain homogenates to a greater extent than the standard antioxidant, ascorbic acid".
Additionally, in the review literature of a number of such drugs mostly in the form of their extracts (holistic approach) or in some, as active principles isolated from them, have been evaluated for their antistress activity by a number of tests which include open-field behavior, researchers found that
* Fennel may have a strong effect in reduced stress in tested mice through observation of swimming endurance and hexobarbitone sleeping time in association with stress in induction of anxiety.
* Fennel inhibited the production of the level of stress hormone corticosterone produced in the cortex of the adrenal gland.
* Fennel increased the production of antioxidants and enhanced the antioxidant defense of hosts such as Superoxide Dismutase (SOD) and sorbitol dehydrogenase (SDH), in inhibiting overexpression of ROS-in initiated chain reactions caused by chronic stress.
* Fennel inhibited levels of MAO in association with alternation of mood and mental conditions.
Finally, the application of fennel also reduced the tension of the central nervous system in response to stress impact, thus reducing neurotransmitter levels in stimulated production of stress hormones in facilitated ROS production, depression, anxiety,.......
The above illustration was supported by the application of fennel oil in exerted significant anti-psychiatric disorders caused by chronic stress such as depression and anxiety in tested mice respectively treated with water, fluoxetine (0.3 mg/kg), and fennel oil (0.5 ml/day) conducted by the Aga Khan University
According to the study, repeated administration of fennel oil for 3 weeks exerted significant antidepressant- and anxiolytic-like effects, observed by struggling time in forced swim test (FST) and time spent in open arm in the elevated plus maze (EPM) comparable to fluoxetine treatment group.
Interestingly, the rats treated group also exhibited high levels of antioxidants in inhibited ROS in facilitated production of free radicals through lipid peroxidation.
Taken together, fennel with abundant phytochemicals may be considered a functional food in reduced stress implication in the initiation of related diseases.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) (2) Foeniculum vulgare Mill (Umbelliferae) Attenuates Stress and Improves Memory in Wister Rats by S Koppula, H Kumar(Tropical Journal of Pharmaceutical Research)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
Fennel may have a potential and positive effect in reducing stress implications, some scientists suggested.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Society and environment impact stress conditions, over a prolonged period of time, which may induce a change of behavior, leading to disturbances in normal physiological functioning due to increased free radicals generation in the initiated onset of hypertension, neurosis, immune suppression, and other physical and mental disorders.
In the study to evaluate the anti-stress and memory-enhancing properties of F. Vulgare extract in experimentally stress rats at doses of 50, 100, and 200 mg/kg body weight administered orally with an orogastric tube researchers found that rats treated with all doses exert a significant effect in reduced stress implication linearly, observed by Urinary levels of vanillylmandelic acid (VMA) assay in 24 hours.
Further analysis of the rat group treated fennel with an additional injection of ascorbic acid also found that the secretion of urinary ascorbic acid levels increased from 65.74 to 78.59, 108.41, and 125.82 μg/kg within the same period on doses of 50, 100, and 200 mg/kg body weight respectively in compared to the untreated control group.
These results indicated that fennel has a stronger impact on reduced chronic stress connotation compared to both ascorbic acid and control groups.
Moreover, the group treatment group also displayed a reduced expression of lipid peroxidation in both rat liver and brain homogenates catalyzed by the stress in induction of ROS production and reduced natural antioxidant defense compared to the rat group treated with ascorbic acid.
Dr. S Koppula,, the lead author, after taking into account other confounders said, "The (Fennel) extract also exhibited potent antioxidant effect by inhibition of lipid peroxidation in both rat liver and brain homogenates to a greater extent than the standard antioxidant, ascorbic acid".
Additionally, in the review literature of a number of such drugs mostly in the form of their extracts (holistic approach) or in some, as active principles isolated from them, have been evaluated for their antistress activity by a number of tests which include open-field behavior, researchers found that
* Fennel may have a strong effect in reduced stress in tested mice through observation of swimming endurance and hexobarbitone sleeping time in association with stress in induction of anxiety.
* Fennel inhibited the production of the level of stress hormone corticosterone produced in the cortex of the adrenal gland.
* Fennel increased the production of antioxidants and enhanced the antioxidant defense of hosts such as Superoxide Dismutase (SOD) and sorbitol dehydrogenase (SDH), in inhibiting overexpression of ROS-in initiated chain reactions caused by chronic stress.
* Fennel inhibited levels of MAO in association with alternation of mood and mental conditions.
Finally, the application of fennel also reduced the tension of the central nervous system in response to stress impact, thus reducing neurotransmitter levels in stimulated production of stress hormones in facilitated ROS production, depression, anxiety,.......
The above illustration was supported by the application of fennel oil in exerted significant anti-psychiatric disorders caused by chronic stress such as depression and anxiety in tested mice respectively treated with water, fluoxetine (0.3 mg/kg), and fennel oil (0.5 ml/day) conducted by the Aga Khan University
According to the study, repeated administration of fennel oil for 3 weeks exerted significant antidepressant- and anxiolytic-like effects, observed by struggling time in forced swim test (FST) and time spent in open arm in the elevated plus maze (EPM) comparable to fluoxetine treatment group.
Interestingly, the rats treated group also exhibited high levels of antioxidants in inhibited ROS in facilitated production of free radicals through lipid peroxidation.
Taken together, fennel with abundant phytochemicals may be considered a functional food in reduced stress implication in the initiation of related diseases.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) (2) Foeniculum vulgare Mill (Umbelliferae) Attenuates Stress and Improves Memory in Wister Rats by S Koppula, H Kumar(Tropical Journal of Pharmaceutical Research)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
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