#Herbal #Ashwagandha Inhibits the Risk of #Diabetes by Protecting the Beta Cells of Pancreas and Increasing thr Antioxidant Activity, Researchers Show

Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream. Insulin resistance and hyperglycemia are hallmarks of diabetes.

In other words, insulin produced by the pancreas is either blocked by the clogging-up of the insulin receptors by fat and cholesterol or the death of beta cells in the pancreas. In some cases, diabetes can also be associated with autoimmune disease, attacking the beta cells.

There are some major types of diabetes, including the best known, type 1 and 2.
* Type 1 diabetes is associated with a genetic proposition that leads to the immune system to attack insulin-producing cells of the pancreas.

* Type 2 diabetes (acquired diabetes), is a condition caused by either the pancreas doesn't produce enough insulin, or the insulin does not work properly due to dysfunction of the insulin receptors.

In pregnancy, gestational diabetes is a type of diabetes occurred during the second or third trimester of pregnancy. Gestation diabetes goes away after giving birth.

However, omen with gestation diabetes is associated with a substantial risk of diabetes developing sometimes in the future.

Epidemiologically, obesity, an unhealthy lifestyle with physical inactivity are some of the most common risk factor associated with the slow onset of diabetes.

Interestingly, some researchers suggested, night shifts workers accompanied by unhealthy lifestyles are linking to a high risk of type 2 diabetes.

" risk of type 2 diabetes is actually higher than simply adding the individual risks associated with unhealthy lifestyle and shift work together, indicating that combining an unhealthy lifestyle with irregular night-time working adds a further risk".

"It is well-established that unhealthy lifestyle behaviors such as smoking, a poor diet, and little exercise, and being overweight or obese increase the risk of type 2 diabetes. Shift work, especially night shift work, has also been associated with a greater risk of type 2 diabetes".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

With an aim to find a potent compound for the treatment of diabetes, researchers examined the effects of Withania somnifera (WS) on lipid peroxidation (LPO) and pancreas in type 2 diabetic rats.

The study included type 2 diabetes induced by a single intraperitoneal injection of STZ (100 mg/kg) to 2 days old rat pups pretreated by WS.

According to the tested analysis, untreated rats group showed significant levels of lipid peroxidation (LPO) observed by reducing levels of antioxidant enzymes produced by the host including glutathione (GSH) contents and by enzymatic activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT).

However, injection of WS not only caused a significant decrease in blood glucose and tissue LPO levels caused by the application of STZ but also a significant increase in GSH contents, compared to type 2 diabetic control rats.

Furthermore, antioxidant enzymes reduced in the untreated rat such as GPx, GR, GST, SOD, and CAT were also increased compared to type 2 diabetic control rats.

Most importantly, the significant reduction in the number and size of pancreatic beta-cells in STZ rats was normalized upon the administration of WS, evident from the histopathological examination.

In other words, WS protects the cells in the pancreas against oxidation and maintains the integrity of beta cells in insulin production in type 2 diabetes rats.

Based on the findings, researchers said, "WS has shown strong free radical scavenging activity and helped in improving the non-enzymatic and enzymatic antioxidants in type 2 diabetic rats".


Taken altogether, Ashwagandha WS may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of type 2 diabetes, pending to the results of large example size and multicenter study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effect of Withania somnifera against oxidative stress and pancreatic beta-cell damage in type 2 diabetic rats by Anwer T1, Sharma M, Pillai KK, Khan G. (PubMed)
(2) Oral supplementation of standardized extract of Withania somnifera protects against diabetes-induced testicular oxidative impairments in prepubertal rats by Kyathanahalli CN1, Manjunath MJ, Muralidhara. (PubMed)
(3) Night shifts and an unhealthy lifestyle linked to high risk of type 2 diabetes by BMJ

#WhiteCabbage #Essentialoil (EO) Inhibits Oxidativestress Against Liver Injury, According to Studies

Kyle J. Norton

The liver is the largest internal organ in the human body, and plays an essential role in filtering blood from the intestine before passing it to other parts of the body.

The organ also produces cholesterol, a waxy substance that is needed to aid digestion and build strong cell membranes, production of steroid hormones, and vitamins.

Liver injury may be a result caused by physical impact or penetrating trauma. In some cases, liver injury can also be induced by toxicity, leading to acute liver injury.

Liver injury can be mild or severe. In a mild case, liver injury can recover itself. However, in severe cases. surgery to stop the bleeding and remove the part of the injury may be necessary.

According to the statistics, liver injury has been found to constitute 5% of all traumas, making it the most common abdominal injury.


Other most common symptoms associated with liver injury are shocks due to severe bleeding inducing a rapid heart rate, rapid breathing, and cold, clammy, pale, or bluish skin.

In some cases, blood accumulated in the abdomen may irritate the abdominal tissue, leading to symptoms of abdominal pain swelling, and tenderness.

The severity of a liver injury can be diagnosed by computed tomography (CT) or ultrasonography.

Depending on the size of the wound, most cases of liver injury are healed by themselves. However, in severe cases, hospitalization may be necessary if the bleeding does not stop.

The most common cause of liver injury is an overdose of medicine which has been found to be the number 1 factor.


Cabbage is a species of Brassica oleracea belonging to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.

In finding a natural whole for the improvement of liver diseases, researchers examined the hepatoprotective properties of the essential oil (EO) from white cabbage.

In acute carbon tetrachloride (CT)-induced liver damage,
* Bocfal EO contained organic polysulphides (OPSs), such as dimethyl trisulphide (DMTS) 65.43 ± 4.92% and dimethyl disulfidefood (DMDS) 19.29 ± 2.16% as major constituents.

* Bocfal EO and DMTS were found to be potent TBARS, a byproduct of lipid peroxidation inhibitors with IC50 values of 0.51 and 3 mg/L, respectively.


* Bocfal EO demonstrated better hepatoprotective properties than did DADS (p < 0.05), although both slightly affected the hepatic parenchyma per se.

Based on the findings, researchers said, "The antioxidant properties of Bocfal EO and DMTS may be the mechanism of hepatoprotective action; the parenchymal disturbances by Bocfal EO or DADS alone may be related to the high doses used".

Taken altogether, cabbage process anti-liver injury, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of antioxidant and hepatoprotective effects of white cabbage essential oil by Morales-López J1, Centeno-Álvarez M2, Nieto-Camacho A3, López MG4, Pérez-Hernández E5, Pérez-Hernández N1, Fernández-Martínez E. (PubMed).

#Lycopene Normalizes the LiverWeight, Hepatic TC, and Serum LDL in Non Alcoholic Fatty Liver Disease Patients, Researchers Find

Kyle J. Norton

The liver is the largest internal and detoxed organ which not only cleanses the blood from the intestinal tract before passing the blood to nourish other tissues and organs in the body but also secrets bile to aid digestion, build strong cell membranes, and produces vitamin D, and steroid hormones.

Additionally, antioxidant enzymes produced by the liver that inhibit free radicals oxidation also play an essential role in reducing the risk of oxidative stress, the major cause of protein, lipid, and cellular damage.

Liver disease is a class of health problems that cause the reduced function of the liver.

Nonalcoholic fatty liver disease (NAFLD) is a chronic condition induced by the onset of cirrhosis and liver cancer caused by fat accumulated in the liver over time, with no influence of excessive alcohol use. The disease can be classified into the types of non-inflammatory fatty liver (NAFL) and inflammatory nonalcoholic steatohepatitis (NASH).

Cirrhosis, in the late stage of liver scarring, as the liver tries to heal itself by halting inflammation, inducing symptoms of ascites, swell esophageal varices, hepatic encephalopathy, complications of liver cancer, and liver failure.

According to the statistics provided by the American Liver Association, in the US about 100 million Americans are living with Non-Alcoholic Fatty Liver Disease.

Believe it or not, non-Alcoholic Fatty Liver Disease (NAFLD), is also the most common form of liver disease in children and has more than doubled over the past 20 years.

The 2016 joint study led by the Autonomous University of Queretaro, showed that lycopene (LYC) may be effective on a nonalcoholic fatty liver disease (NAFLD) model induced with a high-fat diet (HFD).

Some researchers suggested that the increased incidence of non-alcoholic fatty liver disease (NAFLD) in Americans that causes the onset of obesity may be correlated with the promotion of a high-fat diet.

Dr. Jensen VS, the lead scientist said, "In humans and animal models, excessive intake of dietary fat, fructose, and cholesterol have been linked to the development of non-alcoholic fatty liver disease (NAFLD)".

And, "dietary fat and cholesterol are the primary drivers of NAFLD development and progression in rats, while fructose mostly exerts its effect on the circulating lipid pool".

Sprague-Dawley rats selected for the study induced an NAFLD model by either a normal diet (ND·4w) or an HFD (HFD·4w) during 4 weeks

Then, rats from the ND·4w group continued for 4 weeks with the same diet (ND·8w), and rats from HFD were fed during 4 weeks with an ND (HFD·4w+ND·4w) or an ND plus LYC (HFD·4w+ND+LYC·4w).

Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

Based on the tested analysis, ND plus LYC showed a significant effect on NAFLD observed by the normalizing liver weight, hepatic TC, and serum LDL.

Additionally, the ND plus LYC fed group demonstrated the reversal of some macroscopic and microscopic images of livers.

However, lycopene failed to inhibit the liver stress markers such as malondialdehyde level and serum aspartate aminotransferase activity during the period of study.


Dr. Piña-Zentella RM, the lead scientist after taking other factors into account wrote, "The results from this study suggest the potentially protective role of LYC against NAFLD".

Taken altogether, lycopene found in tomato may be considered a supplement for the prevention and treatment of Nonalcoholic Fatty Liver Disease, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene Improves Diet-Mediated Recuperation in Rat Model of Nonalcoholic Fatty Liver Disease by Piña-Zentella RM1, Rosado JL1, Gallegos-Corona MA2, Madrigal-Pérez LA3, García OP1, Ramos-Gomez M. (PubMed).

#Fennel Comibined with #AscorbicAcid Intake Daily Are Associated with a Reduced Daily Stress in the Workplaces, Scientists Suggest

Kyle J. Norton

Fennel may have a potential and positive effect in reducing stress implications, some scientists suggested.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Society and environment impact stress conditions, over a prolonged period of time, which may induce a change of behavior, leading to disturbances in normal physiological functioning due to increased free radicals generation in the initiated onset of hypertension, neurosis, immune suppression, and other physical and mental disorders.

In the study to evaluate the anti-stress and memory-enhancing properties of F. Vulgare extract in experimentally stress rats at doses of 50, 100, and 200 mg/kg body weight administered orally with an orogastric tube researchers found that rats treated with all doses exert a significant effect in reduced stress implication linearly, observed by Urinary levels of vanillylmandelic acid (VMA) assay in 24 hours.

Further analysis of the rat group treated fennel with an additional injection of ascorbic acid also found that the secretion of urinary ascorbic acid levels increased from 65.74 to 78.59, 108.41, and 125.82 μg/kg within the same period on doses of 50, 100, and 200 mg/kg body weight respectively in compared to the untreated control group.

These results indicated that fennel has a stronger impact on reduced chronic stress connotation compared to both ascorbic acid and control groups.

Moreover, the group treatment group also displayed a reduced expression of lipid peroxidation in both rat liver and brain homogenates catalyzed by the stress in induction of ROS production and reduced natural antioxidant defense compared to the rat group treated with ascorbic acid.



Dr. S Koppula,, the lead author, after taking into account other confounders said, "The (Fennel) extract also exhibited potent antioxidant effect by inhibition of lipid peroxidation in both rat liver and brain homogenates to a greater extent than the standard antioxidant, ascorbic acid".


Additionally, in the review literature of a number of such drugs mostly in the form of their extracts (holistic approach) or in some, as active principles isolated from them, have been evaluated for their antistress activity by a number of tests which include open-field behavior, researchers found that
* Fennel may have a strong effect in reduced stress in tested mice through observation of swimming endurance and hexobarbitone sleeping time in association with stress in induction of anxiety.

* Fennel inhibited the production of the level of stress hormone corticosterone produced in the cortex of the adrenal gland.

* Fennel increased the production of antioxidants and enhanced the antioxidant defense of hosts such as Superoxide Dismutase (SOD) and sorbitol dehydrogenase (SDH), in inhibiting overexpression of ROS-in initiated chain reactions caused by chronic stress.

* Fennel inhibited levels of MAO in association with alternation of mood and mental conditions.

Finally, the application of fennel also reduced the tension of the central nervous system in response to stress impact, thus reducing neurotransmitter levels in stimulated production of stress hormones in facilitated ROS production, depression, anxiety,.......

The above illustration was supported by the application of fennel oil in exerted significant anti-psychiatric disorders caused by chronic stress such as depression and anxiety in tested mice respectively treated with water, fluoxetine (0.3 mg/kg), and fennel oil (0.5 ml/day) conducted by the Aga Khan University

According to the study, repeated administration of fennel oil for 3 weeks exerted significant antidepressant- and anxiolytic-like effects, observed by struggling time in forced swim test (FST) and time spent in open arm in the elevated plus maze (EPM) comparable to fluoxetine treatment group.

Interestingly, the rats treated group also exhibited high levels of antioxidants in inhibited ROS in facilitated production of free radicals through lipid peroxidation.

Taken together, fennel with abundant phytochemicals may be considered a functional food in reduced stress implication in the initiation of related diseases.


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Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) (2) Foeniculum vulgare Mill (Umbelliferae) Attenuates Stress and Improves Memory in Wister Rats by S Koppula, H Kumar(Tropical Journal of Pharmaceutical Research)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)

Serum Levels of #Lycopene Are Associated with the Risk of Metabolic Syndrome, According to Reserachers

Kyle J. Norton

A metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and type 2 diabetes, including high blood pressure, sugar, cholesterol, and triglyceride levels, and excess body fat around the waist.
Epidemiological studies suggest if you have 3 of the above syndrome you have metabolic syndrome.

According to statistics, metabolic syndrome is a growing prevalent in the Western world, In the US, 30% of Americans are living with metabolic syndrome,

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, that among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

The most common metabolic syndrome are age, family history of metabolic syndrome, physical activity, and women diagnosed with polycystic ovary syndrome.

Common complications of untreated metabolic syndrome epidemiologically have been found by experts to complicate chronic illnesses such as atherosclerosis, nonalcoholic fatty liver disease, and kidney diseases.

Symptoms of signs of metabolic syndrome depend on the types of affected conditions and complications.

Some researchers suggested that in the US, metabolic syndrome may be correlated with the promotion of a high-fat diet over the past few decades.

Dr. Silvia Moreno-Fernández wrote, "The widespread of MetS in actual society, mainly in developed countries, is becoming an important health problem and is increasing the need to develop new treatments against this pathology is increasing fast".

And, "High-fat/high-glucose fed rats showed an increased bodyweight, abdominal circumference, and fat deposition, combined with oxidative stress, impaired glucose tolerance, dyslipidemia, and mechanical allodynia. Altogether, our results showed an early-stage MetS which, in addition, could lead to T2DM and cardiovascular disease development over time in HFG animals. ".

The results strongly suggested that both metabolic syndrome and obesity in the US population are attributed to the Western diet pattern.

In other words, by changing to a healthy diet such as a traditional diet, the risk of obesity and metabolic syndrome can be decreased substantially.


Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

With an aim to find a potent compound for reducing the risk of cardiovascular disease and diabetes, researchers examined the effects of lycopene on metabolic syndrome.

In a total of 13 196 participants, aged 20 years and older, divided into three groups according to serum concentrations of lycopene, researchers found that the prevalence of the metabolic syndrome associated with levels of antioxidants was significantly higher in the normal and overweight groups compared to the obese group.

In other words, the risk of metabolic syndrome depending on the levels of lycopene in the body only affects people with normal weight or overweight.

Additionally, the study included A total of 2499 participants 20 years and older with metabolic syndrome that were divided into 3 groups based on their serum concentration of lycopene suggesting that levels of lycopene also showed significant effects on HRs of mortality.

In other words, people with higher levels, compared to those of lower serum lycopene concentration. have a lower mortality rate and hazard ratios (HR).

Taken altogether, lycopene found in tomatoes may have a strong effect on the initiation of metabolic syndrome, particularly in normal-weight and overweight individuals, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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BaNorton'sKyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nrightsion, All right reserved)
Health article writer and res10,000r; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Higher levels of serum lycopene are associated with reduced mortality in individuals with metabolic syndrome by Han GM1, Meza JL2, Soliman GA3, Islam KM1, Watanabe-Galloway S. (PubMed)
(2) The influence of BMI on the association between serum lycopene and the metabolic syndrome by Han GM1, Soliman GA2, Meza JL3, Islam KM1, Watanabe-Galloway S. (PubMed)
(3) High Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental Rat Model by Silvia Moreno-Fernández,1,2 Marta Garcés-Rimón,3 Gema Vera,2,4 Julien Astier,5Jean François Landrier,5 and Marta Miguel. (PMC)

#Alliin, a Sulfoxide Compound Derived From #Garlic Reduces Metabolic Risk Factors Against The Onset of Heart Disease, Stroke, and Diabetes in Vivo

Kyle J. Norton

Metabolic risk factors are the cluster conditions are associated with an increased risk of heart disease, stroke, and diabetes.
In other words, if you have 3 or more risk factors of too much fat around the waist, elevated blood pressure, high triglycerides, elevated blood sugar, and low HDL cholesterol, you are considered at a higher risk of cardiovascular disease and diabetes compared to those who have less.

There is no single cause of the metabolic syndrome. However, most cases of MetS are found in overweight and obese patients, particularly in those with insulin resistance, the condition caused by the inability of the body to use insulin properly in converting sugar to energy.

Symptoms depend on the risk factors that the patients have, such as high blood pressure cholesterol and glucose.

Other than the aforementioned risk factors, epidemiologically, aging, family history, physical inactivity, and women with polycystic ovary syndrome are at a higher risk of the condition onset.

Some researchers suggested the rise of metabolic syndrome in the US over the past few decades may be correlated with the promotion of a high-fat diet in the Western world.

Dr. Wabitsch, M., the lead scientist wrote, "Specific alterations of the Western Diet uniquely drive this process and are unrelated to calories. These alterations include too little fiber, omega-3 fatty acids, and micronutrients, and too many omega-6 fatty acids, trans-fats, branched-chain amino acids, ethanol, and fructose. The food industry invokes personal responsibility while denying any corporate responsibility and citing scientific, policy, and social arguments. However, their responses obfuscate the scientific truth in order to obviate their culpability".


Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

In finding a natural compound for the treatment of metabolic risk in diabetics, researchers investigated the effects of alliin (S-allyl cysteine sulfoxide) a bioactive sulfoxide compound derived from garlic against metabolic risk factors in a diet-induced animal model.

The selected diet-induced obese C57BL/6J DIO mice were treated by drinking water with or without alliin (0.1 mg/ml) for 8 weeks.

According to the tested assays, alliin showed no significant effect on the body weight, adiposity, or energy balance, however, alliin significantly reduced the levels of glucose homeostasis, increased insulin sensitivity, and the lipid profile associated with metabolic risk factors.

The efficacy of alliin against the onset of hyperglycemia in obese tested mice was attributed at least in part by balancing the levels of gut microbiota.

In other words, alliin modulated the intestinal microbiota composition by decreasing levels of Lachnospiraceae and increasing levels of Ruminococcaceae.

Based on the findings, researchers said, "Alliin has nutraceutical or even medicinal potential in the prevention of diabetes and lipid metabolic disorders(in the induction of hyperglycemia and hyperlipidemia)".

Furthermore, in order to reveal more information about alliin antimetabolic activity, researchers compared the therapeutic effects of alliin extracted from garlic leaves of plants grown under ex-situ and in-situ conditions.


According to the results of bioanalysis on normal and alloxan-induced diabetic rats in a week experiment
* Alliin produced from in situ grown plants showed a significant reduction of the serum glucose, triglycerides, total lipids, total cholesterol, low-density lipoprotein (LDL)-, and very-low-density lipoprotein (VLDL)-cholesterol in diabetic rats of 54%, 15%, 14%, 20%, 24%, and 15% repetitively.


* Alliin produced from ex-situ grown plants showed a lesser effect in the reduction of 35%, 14%, 10%, 12%, 17%, and 11%, respectively

* Both were compared to those treated with distilled water.

* Additionally, alliin produced from in and ex-situ-grown plants showed no effect on high-density lipoprotein (HDL)-cholesterol.

Based on the findings, Dr. Nasim SA, the lead scientist wrote, "These findings demonstrate leaf extract obtained from plants grown under in situ conditions possess higher therapeutic efficiency in comparison with leaf extract obtained from plants grown under ex-situ condition".

In other words, alliin produced from originally grown plants is more effective compared to alliin produced by ex-situ.

Taken altogether, alliin may be considered a supplement for reducing metabolic risk with no side effect, responding to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in a form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice.
Zhai B1, Zhang C1, Sheng Y1, Zhao C2, He X1,3, Xu W1,3, Huang K1,3, Luo Y. (PubMed)
(2) Alliin obtained from leaf extract of garlic grown under in situ conditions possesses higher therapeutic potency as analyzed in alloxan-induced diabetic rats by Nasim SA1, Dhir B, Kapoor R, Fatima S, Mahmooduzzafar, Mujib A. (PubMed)
(3) Metabolic Syndrome and Obesity in Childhood and Adolescence by Editor(s): Kiess, W. (Leipzig), Wabitsch, M. (Ulm), Maffeis, C. (Verona), and Sharma, A.M. (Edmonton, Alta.). (Karger)

#Herbal #Dandelion Inhibits α-glucosidase Associated with Motabolic Modifier in a Reduced Risk of #CardiovascularDisease, Researchers Suggest

Kyle J. Norton

A metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and types 2 diabetes, including high blood pressure, sugar, cholesterol, triglyceride levels, and excess body fat around the waist.

Cardiovascular diseases refer to heart diseases, affecting millions of people in the world. According to statistics, over 17.7 million people died from CVDs in 2015, Hyperlipidaemia and hypertension are the risk factors for the diseases.


Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes occurs when cells in the pancreas die off or receptor sites are clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

According to statistics, metabolic syndrome is growing prevalence in the Western world, In the US, 30% of Americans are living with metabolic syndrome,

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, that among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

The most common metabolic syndrome are age, family history of metabolic syndrome, physical activity, and women diagnosed with polycystic ovary syndrome.

Symptoms of signs of metabolic syndrome depend on the types of affected conditions and complications.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of cardiovascular diseases, scientists examined the effects of Boldocynara® (Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus) as a combination product and its individual extracts on key enzymes relevant to metabolic syndrome.

According to the tested differentiation, the combination exerted moderate to weak effects on the tested liver enzymes against metabolic syndrome.


In the individual herb analysis, * Peumus boldus extract exhibited pronounced inhibitory activities on α-glucosidase (80% inhibition at 100 µg/ml, IC50: 17.56 µg/ml) associated with a metabolic modifier that could reduce the risk of CVD in patients with the metabolic syndrome.


* Silybum marianum had moderate pancreatic lipase (PL) inhibitory activities (30% at 100 µg/ml) involved in lipid metabolism disorder.

* Cynara scolymus showed moderate ACE inhibitory activity (31% at 100 µg/ml) in reducing the risk of CVD.

In other words, all individual herbal medicine work synergistically to induce inhibitory activity against all parameters in inducing the risk of metabolic syndrome.

Based on the results, researchers suggest, " our results indicate some moderate potential of the dietary supplement Boldocynara® and its single ingredients for the prevention of metabolic disorders".


Taken together, Dandelion used in a combination with other herbs may be considered a formula for the prevention of metabolic syndrome, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In vitro inhibitory potential of Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus on key enzymes relevant to metabolic syndrome by Villiger A1, Sala F1, Suter A2, Butterweck V. (PubMed)