#Lycopene Normalizes the LiverWeight, Hepatic TC, and Serum LDL in Non Alcoholic Fatty Liver Disease Patients, Researchers Find

Kyle J. Norton

The liver is the largest internal and detoxed organ which not only cleanses the blood from the intestinal tract before passing the blood to nourish other tissues and organs in the body but also secrets bile to aid digestion, build strong cell membranes, and produces vitamin D, and steroid hormones.

Additionally, antioxidant enzymes produced by the liver that inhibit free radicals oxidation also play an essential role in reducing the risk of oxidative stress, the major cause of protein, lipid, and cellular damage.

Liver disease is a class of health problems that cause the reduced function of the liver.

Nonalcoholic fatty liver disease (NAFLD) is a chronic condition induced by the onset of cirrhosis and liver cancer caused by fat accumulated in the liver over time, with no influence of excessive alcohol use. The disease can be classified into the types of non-inflammatory fatty liver (NAFL) and inflammatory nonalcoholic steatohepatitis (NASH).

Cirrhosis, in the late stage of liver scarring, as the liver tries to heal itself by halting inflammation, inducing symptoms of ascites, swell esophageal varices, hepatic encephalopathy, complications of liver cancer, and liver failure.

According to the statistics provided by the American Liver Association, in the US about 100 million Americans are living with Non-Alcoholic Fatty Liver Disease.

Believe it or not, non-Alcoholic Fatty Liver Disease (NAFLD), is also the most common form of liver disease in children and has more than doubled over the past 20 years.

The 2016 joint study led by the Autonomous University of Queretaro, showed that lycopene (LYC) may be effective on a nonalcoholic fatty liver disease (NAFLD) model induced with a high-fat diet (HFD).

Some researchers suggested that the increased incidence of non-alcoholic fatty liver disease (NAFLD) in Americans that causes the onset of obesity may be correlated with the promotion of a high-fat diet.

Dr. Jensen VS, the lead scientist said, "In humans and animal models, excessive intake of dietary fat, fructose, and cholesterol have been linked to the development of non-alcoholic fatty liver disease (NAFLD)".

And, "dietary fat and cholesterol are the primary drivers of NAFLD development and progression in rats, while fructose mostly exerts its effect on the circulating lipid pool".

Sprague-Dawley rats selected for the study induced an NAFLD model by either a normal diet (ND·4w) or an HFD (HFD·4w) during 4 weeks

Then, rats from the ND·4w group continued for 4 weeks with the same diet (ND·8w), and rats from HFD were fed during 4 weeks with an ND (HFD·4w+ND·4w) or an ND plus LYC (HFD·4w+ND+LYC·4w).

Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

Based on the tested analysis, ND plus LYC showed a significant effect on NAFLD observed by the normalizing liver weight, hepatic TC, and serum LDL.

Additionally, the ND plus LYC fed group demonstrated the reversal of some macroscopic and microscopic images of livers.

However, lycopene failed to inhibit the liver stress markers such as malondialdehyde level and serum aspartate aminotransferase activity during the period of study.


Dr. Piña-Zentella RM, the lead scientist after taking other factors into account wrote, "The results from this study suggest the potentially protective role of LYC against NAFLD".

Taken altogether, lycopene found in tomato may be considered a supplement for the prevention and treatment of Nonalcoholic Fatty Liver Disease, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene Improves Diet-Mediated Recuperation in Rat Model of Nonalcoholic Fatty Liver Disease by Piña-Zentella RM1, Rosado JL1, Gallegos-Corona MA2, Madrigal-Pérez LA3, García OP1, Ramos-Gomez M. (PubMed).

#Fennel Comibined with #AscorbicAcid Intake Daily Are Associated with a Reduced Daily Stress in the Workplaces, Scientists Suggest

Kyle J. Norton

Fennel may have a potential and positive effect in reducing stress implications, some scientists suggested.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Society and environment impact stress conditions, over a prolonged period of time, which may induce a change of behavior, leading to disturbances in normal physiological functioning due to increased free radicals generation in the initiated onset of hypertension, neurosis, immune suppression, and other physical and mental disorders.

In the study to evaluate the anti-stress and memory-enhancing properties of F. Vulgare extract in experimentally stress rats at doses of 50, 100, and 200 mg/kg body weight administered orally with an orogastric tube researchers found that rats treated with all doses exert a significant effect in reduced stress implication linearly, observed by Urinary levels of vanillylmandelic acid (VMA) assay in 24 hours.

Further analysis of the rat group treated fennel with an additional injection of ascorbic acid also found that the secretion of urinary ascorbic acid levels increased from 65.74 to 78.59, 108.41, and 125.82 μg/kg within the same period on doses of 50, 100, and 200 mg/kg body weight respectively in compared to the untreated control group.

These results indicated that fennel has a stronger impact on reduced chronic stress connotation compared to both ascorbic acid and control groups.

Moreover, the group treatment group also displayed a reduced expression of lipid peroxidation in both rat liver and brain homogenates catalyzed by the stress in induction of ROS production and reduced natural antioxidant defense compared to the rat group treated with ascorbic acid.



Dr. S Koppula,, the lead author, after taking into account other confounders said, "The (Fennel) extract also exhibited potent antioxidant effect by inhibition of lipid peroxidation in both rat liver and brain homogenates to a greater extent than the standard antioxidant, ascorbic acid".


Additionally, in the review literature of a number of such drugs mostly in the form of their extracts (holistic approach) or in some, as active principles isolated from them, have been evaluated for their antistress activity by a number of tests which include open-field behavior, researchers found that
* Fennel may have a strong effect in reduced stress in tested mice through observation of swimming endurance and hexobarbitone sleeping time in association with stress in induction of anxiety.

* Fennel inhibited the production of the level of stress hormone corticosterone produced in the cortex of the adrenal gland.

* Fennel increased the production of antioxidants and enhanced the antioxidant defense of hosts such as Superoxide Dismutase (SOD) and sorbitol dehydrogenase (SDH), in inhibiting overexpression of ROS-in initiated chain reactions caused by chronic stress.

* Fennel inhibited levels of MAO in association with alternation of mood and mental conditions.

Finally, the application of fennel also reduced the tension of the central nervous system in response to stress impact, thus reducing neurotransmitter levels in stimulated production of stress hormones in facilitated ROS production, depression, anxiety,.......

The above illustration was supported by the application of fennel oil in exerted significant anti-psychiatric disorders caused by chronic stress such as depression and anxiety in tested mice respectively treated with water, fluoxetine (0.3 mg/kg), and fennel oil (0.5 ml/day) conducted by the Aga Khan University

According to the study, repeated administration of fennel oil for 3 weeks exerted significant antidepressant- and anxiolytic-like effects, observed by struggling time in forced swim test (FST) and time spent in open arm in the elevated plus maze (EPM) comparable to fluoxetine treatment group.

Interestingly, the rats treated group also exhibited high levels of antioxidants in inhibited ROS in facilitated production of free radicals through lipid peroxidation.

Taken together, fennel with abundant phytochemicals may be considered a functional food in reduced stress implication in the initiation of related diseases.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) (2) Foeniculum vulgare Mill (Umbelliferae) Attenuates Stress and Improves Memory in Wister Rats by S Koppula, H Kumar(Tropical Journal of Pharmaceutical Research)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)

Serum Levels of #Lycopene Are Associated with the Risk of Metabolic Syndrome, According to Reserachers

Kyle J. Norton

A metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and type 2 diabetes, including high blood pressure, sugar, cholesterol, and triglyceride levels, and excess body fat around the waist.
Epidemiological studies suggest if you have 3 of the above syndrome you have metabolic syndrome.

According to statistics, metabolic syndrome is a growing prevalent in the Western world, In the US, 30% of Americans are living with metabolic syndrome,

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, that among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

The most common metabolic syndrome are age, family history of metabolic syndrome, physical activity, and women diagnosed with polycystic ovary syndrome.

Common complications of untreated metabolic syndrome epidemiologically have been found by experts to complicate chronic illnesses such as atherosclerosis, nonalcoholic fatty liver disease, and kidney diseases.

Symptoms of signs of metabolic syndrome depend on the types of affected conditions and complications.

Some researchers suggested that in the US, metabolic syndrome may be correlated with the promotion of a high-fat diet over the past few decades.

Dr. Silvia Moreno-Fernández wrote, "The widespread of MetS in actual society, mainly in developed countries, is becoming an important health problem and is increasing the need to develop new treatments against this pathology is increasing fast".

And, "High-fat/high-glucose fed rats showed an increased bodyweight, abdominal circumference, and fat deposition, combined with oxidative stress, impaired glucose tolerance, dyslipidemia, and mechanical allodynia. Altogether, our results showed an early-stage MetS which, in addition, could lead to T2DM and cardiovascular disease development over time in HFG animals. ".

The results strongly suggested that both metabolic syndrome and obesity in the US population are attributed to the Western diet pattern.

In other words, by changing to a healthy diet such as a traditional diet, the risk of obesity and metabolic syndrome can be decreased substantially.


Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

With an aim to find a potent compound for reducing the risk of cardiovascular disease and diabetes, researchers examined the effects of lycopene on metabolic syndrome.

In a total of 13 196 participants, aged 20 years and older, divided into three groups according to serum concentrations of lycopene, researchers found that the prevalence of the metabolic syndrome associated with levels of antioxidants was significantly higher in the normal and overweight groups compared to the obese group.

In other words, the risk of metabolic syndrome depending on the levels of lycopene in the body only affects people with normal weight or overweight.

Additionally, the study included A total of 2499 participants 20 years and older with metabolic syndrome that were divided into 3 groups based on their serum concentration of lycopene suggesting that levels of lycopene also showed significant effects on HRs of mortality.

In other words, people with higher levels, compared to those of lower serum lycopene concentration. have a lower mortality rate and hazard ratios (HR).

Taken altogether, lycopene found in tomatoes may have a strong effect on the initiation of metabolic syndrome, particularly in normal-weight and overweight individuals, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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BaNorton'sKyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nrightsion, All right reserved)
Health article writer and res10,000r; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Higher levels of serum lycopene are associated with reduced mortality in individuals with metabolic syndrome by Han GM1, Meza JL2, Soliman GA3, Islam KM1, Watanabe-Galloway S. (PubMed)
(2) The influence of BMI on the association between serum lycopene and the metabolic syndrome by Han GM1, Soliman GA2, Meza JL3, Islam KM1, Watanabe-Galloway S. (PubMed)
(3) High Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental Rat Model by Silvia Moreno-Fernández,1,2 Marta Garcés-Rimón,3 Gema Vera,2,4 Julien Astier,5Jean François Landrier,5 and Marta Miguel. (PMC)

#Alliin, a Sulfoxide Compound Derived From #Garlic Reduces Metabolic Risk Factors Against The Onset of Heart Disease, Stroke, and Diabetes in Vivo

Kyle J. Norton

Metabolic risk factors are the cluster conditions are associated with an increased risk of heart disease, stroke, and diabetes.
In other words, if you have 3 or more risk factors of too much fat around the waist, elevated blood pressure, high triglycerides, elevated blood sugar, and low HDL cholesterol, you are considered at a higher risk of cardiovascular disease and diabetes compared to those who have less.

There is no single cause of the metabolic syndrome. However, most cases of MetS are found in overweight and obese patients, particularly in those with insulin resistance, the condition caused by the inability of the body to use insulin properly in converting sugar to energy.

Symptoms depend on the risk factors that the patients have, such as high blood pressure cholesterol and glucose.

Other than the aforementioned risk factors, epidemiologically, aging, family history, physical inactivity, and women with polycystic ovary syndrome are at a higher risk of the condition onset.

Some researchers suggested the rise of metabolic syndrome in the US over the past few decades may be correlated with the promotion of a high-fat diet in the Western world.

Dr. Wabitsch, M., the lead scientist wrote, "Specific alterations of the Western Diet uniquely drive this process and are unrelated to calories. These alterations include too little fiber, omega-3 fatty acids, and micronutrients, and too many omega-6 fatty acids, trans-fats, branched-chain amino acids, ethanol, and fructose. The food industry invokes personal responsibility while denying any corporate responsibility and citing scientific, policy, and social arguments. However, their responses obfuscate the scientific truth in order to obviate their culpability".


Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

In finding a natural compound for the treatment of metabolic risk in diabetics, researchers investigated the effects of alliin (S-allyl cysteine sulfoxide) a bioactive sulfoxide compound derived from garlic against metabolic risk factors in a diet-induced animal model.

The selected diet-induced obese C57BL/6J DIO mice were treated by drinking water with or without alliin (0.1 mg/ml) for 8 weeks.

According to the tested assays, alliin showed no significant effect on the body weight, adiposity, or energy balance, however, alliin significantly reduced the levels of glucose homeostasis, increased insulin sensitivity, and the lipid profile associated with metabolic risk factors.

The efficacy of alliin against the onset of hyperglycemia in obese tested mice was attributed at least in part by balancing the levels of gut microbiota.

In other words, alliin modulated the intestinal microbiota composition by decreasing levels of Lachnospiraceae and increasing levels of Ruminococcaceae.

Based on the findings, researchers said, "Alliin has nutraceutical or even medicinal potential in the prevention of diabetes and lipid metabolic disorders(in the induction of hyperglycemia and hyperlipidemia)".

Furthermore, in order to reveal more information about alliin antimetabolic activity, researchers compared the therapeutic effects of alliin extracted from garlic leaves of plants grown under ex-situ and in-situ conditions.


According to the results of bioanalysis on normal and alloxan-induced diabetic rats in a week experiment
* Alliin produced from in situ grown plants showed a significant reduction of the serum glucose, triglycerides, total lipids, total cholesterol, low-density lipoprotein (LDL)-, and very-low-density lipoprotein (VLDL)-cholesterol in diabetic rats of 54%, 15%, 14%, 20%, 24%, and 15% repetitively.


* Alliin produced from ex-situ grown plants showed a lesser effect in the reduction of 35%, 14%, 10%, 12%, 17%, and 11%, respectively

* Both were compared to those treated with distilled water.

* Additionally, alliin produced from in and ex-situ-grown plants showed no effect on high-density lipoprotein (HDL)-cholesterol.

Based on the findings, Dr. Nasim SA, the lead scientist wrote, "These findings demonstrate leaf extract obtained from plants grown under in situ conditions possess higher therapeutic efficiency in comparison with leaf extract obtained from plants grown under ex-situ condition".

In other words, alliin produced from originally grown plants is more effective compared to alliin produced by ex-situ.

Taken altogether, alliin may be considered a supplement for reducing metabolic risk with no side effect, responding to the confirmation of the larger sample size and multicenter human study.

Intake of alliin in a form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice.
Zhai B1, Zhang C1, Sheng Y1, Zhao C2, He X1,3, Xu W1,3, Huang K1,3, Luo Y. (PubMed)
(2) Alliin obtained from leaf extract of garlic grown under in situ conditions possesses higher therapeutic potency as analyzed in alloxan-induced diabetic rats by Nasim SA1, Dhir B, Kapoor R, Fatima S, Mahmooduzzafar, Mujib A. (PubMed)
(3) Metabolic Syndrome and Obesity in Childhood and Adolescence by Editor(s): Kiess, W. (Leipzig), Wabitsch, M. (Ulm), Maffeis, C. (Verona), and Sharma, A.M. (Edmonton, Alta.). (Karger)

#Herbal #Dandelion Inhibits α-glucosidase Associated with Motabolic Modifier in a Reduced Risk of #CardiovascularDisease, Researchers Suggest

Kyle J. Norton

A metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and types 2 diabetes, including high blood pressure, sugar, cholesterol, triglyceride levels, and excess body fat around the waist.

Cardiovascular diseases refer to heart diseases, affecting millions of people in the world. According to statistics, over 17.7 million people died from CVDs in 2015, Hyperlipidaemia and hypertension are the risk factors for the diseases.


Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes occurs when cells in the pancreas die off or receptor sites are clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

According to statistics, metabolic syndrome is growing prevalence in the Western world, In the US, 30% of Americans are living with metabolic syndrome,

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, that among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

The most common metabolic syndrome are age, family history of metabolic syndrome, physical activity, and women diagnosed with polycystic ovary syndrome.

Symptoms of signs of metabolic syndrome depend on the types of affected conditions and complications.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of cardiovascular diseases, scientists examined the effects of Boldocynara® (Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus) as a combination product and its individual extracts on key enzymes relevant to metabolic syndrome.

According to the tested differentiation, the combination exerted moderate to weak effects on the tested liver enzymes against metabolic syndrome.


In the individual herb analysis, * Peumus boldus extract exhibited pronounced inhibitory activities on α-glucosidase (80% inhibition at 100 µg/ml, IC50: 17.56 µg/ml) associated with a metabolic modifier that could reduce the risk of CVD in patients with the metabolic syndrome.


* Silybum marianum had moderate pancreatic lipase (PL) inhibitory activities (30% at 100 µg/ml) involved in lipid metabolism disorder.

* Cynara scolymus showed moderate ACE inhibitory activity (31% at 100 µg/ml) in reducing the risk of CVD.

In other words, all individual herbal medicine work synergistically to induce inhibitory activity against all parameters in inducing the risk of metabolic syndrome.

Based on the results, researchers suggest, " our results indicate some moderate potential of the dietary supplement Boldocynara® and its single ingredients for the prevention of metabolic disorders".


Taken together, Dandelion used in a combination with other herbs may be considered a formula for the prevention of metabolic syndrome, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In vitro inhibitory potential of Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus on key enzymes relevant to metabolic syndrome by Villiger A1, Sala F1, Suter A2, Butterweck V. (PubMed)

Topical Use, and Combined Ingestion and Topical Use od Products Containing #Turmeric, and #Curcumin Significantly Improve #SkinDisease Severity, According to Studies

Kyle J. Norton

Skin, the large external organ in the human body is the outer layer, with a total area of about 20 square feet which protects the internal organs, bones, and tissues against damage.
The skin processes 3 main layers

* The epidermis is the outermost layer of the skin providing a barrier against infection from environmental pathogens. The outer layers also regulate the amount of water released from the body through transepidermal water loss.

* Dermis is the second layer of skin, containing blood capillaries, nerve endings, sweat glands, hair follicles, and other structures.


* The bottom layer is the subcutaneous fat which has been found to process the protective effect against the dangers of visceral fat.

Skin health refers to the use of material or agents, including topical and oral herbal remedies with the function of protecting the skin cell against environmentally harmful substances, including sun UV light, and microbial infection.

Some researchers suggested that by providing enough nutrition to the skin cells we can maintain healthy skin. In other words, macronutrients including carbohydrates, proteins, and lipids, and micronutrients such as vitamins and essential minerals all work together to maintain healthy skin.


More precisely, we can maintain healthy skin by eating a healthy diet accompanied by moderate exercise and avoiding exposure of skin to harmful substances.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.


The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a natural compound for the enhancement of skin health, researchers examined the active component of turmeric, curcumin used medically to treat a variety of dermatologic diseases in traditional medicine.

The search involved the relationship between products containing turmeric, curcumin, and skin health in the medical databases of PubMed and Embase databases and found a total of 234 articles with only 18 studies that met inclusion criteria.

According to the identified studies, ingestion, topical use, and combined ingestion and topical use showed a statistically significant improvement in skin disease severity in the turmeric/curcumin treatment groups compared with control groups, including conditions of acne, alopecia, atopic dermatitis, facial photoaging, oral lichen planus, pruritus, psoriasis, radiodermatitis, and vitiligo.


Dr. Vaughn AR, the lead scientist after taking into account co and confounder wrote in the final report, "Overall, there is early evidence that turmeric/curcumin products and supplements, both oral and topical, may provide therapeutic benefits for skin health".

In order to reveal more information about curcumin in skin protection, researchers investigated the antioxidative, anti-inflammatory, and antibacterial properties against skin diseases.

According to the tested assays, curcumin exerted protective effects against skin damage caused by chronic ultraviolet B radiation.

Curcumin application also has a strong effect on the protection against skin aging and disorders such as psoriasis, infection, acne, skin inflammation, and skin cancer.

Taken together, turmeric may be considered a supplement for skin health with no side effects, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence by Vaughn AR1, Branum A2, Sivamani RK. (PubMed)
(2) Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review by Panahi Y1, Fazlolahzadeh O2, Atkin SL3, Majeed M4, Butler AE5, Johnston TP6, Sahebkar A. (PubMed)

#Fennel #Essentialoil Extract Exhibits Cytotoxic Activity Against #BreastCancer, Researchers Say

Kyle J. Norton

Fennel may have a potential and therapeutic effect in reducing the risk and treatment of breast cancer, some scientists suggested.

Breast cancer is a medical condition characterized by cell growth disorderly and uncontrollably in the breast tissue. At the later stage, cancerous cells may travel a distance away to infect other healthy tissues and organs.

Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

In the evaluation of the essential oil extracted from fennel activity in human breast cancer cell line (MDA-Mb), researchers found that application of fennel extract exerted a significant effect in inhibition of the expression of cancer cell line at a dose of lower than flower than 10 μg/mL with IC50.

According to the University of Malaya in the investigation of the DNA protecting activity and inhibition of nicotine-induced cancer cell migration of 9 species, fennel exerted a potential effect in the protection of the DNA integrity and inhibition of nicotine-induced cancer cell migration against Murine fibroblasts (3T3-L1) and human breast cancer (MCF-7) cells pre-treated with spice extracts and then exposed to H₂O₂ and nicotine.

Additional analysis suggested that the result of inhibition was attributed to fennel antioxidants of phenols and flavonoids in ameliorated H2O2 in initiated chain activity in the induction of cytotoxicity in altered DNA of the experiment cell line.

Some researchers suggested that the overproduction of hydrogen peroxide may serve as a prodrug in the presence of transition metal ions, in the induced production of highly reactive hydroxyl radicals to initiate DNA damage in precipitated apoptosis.

In other words, the application of highly oxidative hydrogen peroxide in the breast cancer cell line may cause a significant cytotoxic effect in cancer cell death.

These results demonstrated the correlation of the increase of apoptosis with the rise in the generation of reactive oxygen species in cancer cells.

Due to this potential activity, some researchers suggested that hydrogen peroxide overproduced in tumor cells can serve as a prodrug for the treatment of cancer.

On the other hand, the application of H2O2 in healthy cells may induce DNA damage in the initiation of cancer cell development.

Furthermore, fennel scored a statistically significant DNA protecting activity in comparison to other spices, such as ginger with 50 μg/ml in reduced 68% of DNA damage in 3T3-L1 cells.

However, Fennel exerted a lesser effect in inhibited cancer MCF-7 cells with nicotine-induced cell migration in comparison to other spices such as pepper, long pepper, and ginger.

The above differentiation was supported by the joint study led by the Avicenna Tajik State Medical University, in the evaluation of the antioxidant effect of the essential oil of fennel (Foeniculum vulgare) against MCF-7 (human breast adenocarcinoma).
According to the result from Gas chromatographic-mass spectrometric analysis, fennel displayed a moderated antioxidant in precipitated cytotoxic activity against MCF-7 (human breast adenocarcinoma) with IC50 values between 30-210 mg L-1 in comparison to cytotoxic reference compounds.
In fact, the efficacy of fennel essential oil in inhibiting breast cancer proliferation and migration was attributed to the presence of lipophilic secondary metabolites and anise aldehyde, which have the potential to elevate interference with molecular targets in cells by fennel antioxidant compounds such as anethole.

Taken together, fennel and its bioactive compound may be considered functional foods in reduced risk, progression, and treatment of breast cancer. However, intake of fennel supplements should be taken with extreme care in preventing liver acute toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) Analysis and evaluation of the antimicrobial and anticancer activities of the essential oil isolated from Foeniculum vulgare from Hamedan, Iran by Akhbari M1, Kord R1, Jafari Nodooshan S2, Hamedi S3.(PubMed)
(2) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M8.(PubMed)
(3) Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration by Jayakumar R1, Kanthimathi MS.(PubMed)