Kyle J. Norton
Skin, the large external organ in the human body is the outer layer, with a total area of about 20 square feet which protects the internal organs, bones, and tissues against damage.
The skin processes 3 main layers
* The epidermis is the outermost layer of the skin providing a barrier against infection from environmental pathogens. The outer layers also regulate the amount of water released from the body through transepidermal water loss.
* Dermis is the second layer of skin, containing blood capillaries, nerve endings, sweat glands, hair follicles, and other structures.
* The bottom layer is the subcutaneous fat which has been found to process the protective effect against the dangers of visceral fat.
Skin health refers to the use of material or agents, including topical and oral herbal remedies with the function of protecting the skin cell against environmentally harmful substances, including sun UV light, and microbial infection.
Some researchers suggested that by providing enough nutrition to the skin cells we can maintain healthy skin. In other words, macronutrients including carbohydrates, proteins, and lipids, and micronutrients such as vitamins and essential minerals all work together to maintain healthy skin.
More precisely, we can maintain healthy skin by eating a healthy diet accompanied by moderate exercise and avoiding exposure of skin to harmful substances.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound for the enhancement of skin health, researchers examined the active component of turmeric, curcumin used medically to treat a variety of dermatologic diseases in traditional medicine.
The search involved the relationship between products containing turmeric, curcumin, and skin health in the medical databases of PubMed and Embase databases and found a total of 234 articles with only 18 studies that met inclusion criteria.
According to the identified studies, ingestion, topical use, and combined ingestion and topical use showed a statistically significant improvement in skin disease severity in the turmeric/curcumin treatment groups compared with control groups, including conditions of acne, alopecia, atopic dermatitis, facial photoaging, oral lichen planus, pruritus, psoriasis, radiodermatitis, and vitiligo.
Dr. Vaughn AR, the lead scientist after taking into account co and confounder wrote in the final report, "Overall, there is early evidence that turmeric/curcumin products and supplements, both oral and topical, may provide therapeutic benefits for skin health".
In order to reveal more information about curcumin in skin protection, researchers investigated the antioxidative, anti-inflammatory, and antibacterial properties against skin diseases.
According to the tested assays, curcumin exerted protective effects against skin damage caused by chronic ultraviolet B radiation.
Curcumin application also has a strong effect on the protection against skin aging and disorders such as psoriasis, infection, acne, skin inflammation, and skin cancer.
Taken together, turmeric may be considered a supplement for skin health with no side effects, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence by Vaughn AR1, Branum A2, Sivamani RK. (PubMed)
(2) Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review by Panahi Y1, Fazlolahzadeh O2, Atkin SL3, Majeed M4, Butler AE5, Johnston TP6, Sahebkar A. (PubMed)
Saturday, 26 August 2023
#Fennel #Essentialoil Extract Exhibits Cytotoxic Activity Against #BreastCancer, Researchers Say
Kyle J. Norton
Fennel may have a potential and therapeutic effect in reducing the risk and treatment of breast cancer, some scientists suggested.
Breast cancer is a medical condition characterized by cell growth disorderly and uncontrollably in the breast tissue. At the later stage, cancerous cells may travel a distance away to infect other healthy tissues and organs.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the evaluation of the essential oil extracted from fennel activity in human breast cancer cell line (MDA-Mb), researchers found that application of fennel extract exerted a significant effect in inhibition of the expression of cancer cell line at a dose of lower than flower than 10 μg/mL with IC50.
According to the University of Malaya in the investigation of the DNA protecting activity and inhibition of nicotine-induced cancer cell migration of 9 species, fennel exerted a potential effect in the protection of the DNA integrity and inhibition of nicotine-induced cancer cell migration against Murine fibroblasts (3T3-L1) and human breast cancer (MCF-7) cells pre-treated with spice extracts and then exposed to H₂O₂ and nicotine.
Additional analysis suggested that the result of inhibition was attributed to fennel antioxidants of phenols and flavonoids in ameliorated H2O2 in initiated chain activity in the induction of cytotoxicity in altered DNA of the experiment cell line.
Some researchers suggested that the overproduction of hydrogen peroxide may serve as a prodrug in the presence of transition metal ions, in the induced production of highly reactive hydroxyl radicals to initiate DNA damage in precipitated apoptosis.
In other words, the application of highly oxidative hydrogen peroxide in the breast cancer cell line may cause a significant cytotoxic effect in cancer cell death.
These results demonstrated the correlation of the increase of apoptosis with the rise in the generation of reactive oxygen species in cancer cells.
Due to this potential activity, some researchers suggested that hydrogen peroxide overproduced in tumor cells can serve as a prodrug for the treatment of cancer.
On the other hand, the application of H2O2 in healthy cells may induce DNA damage in the initiation of cancer cell development.
Furthermore, fennel scored a statistically significant DNA protecting activity in comparison to other spices, such as ginger with 50 μg/ml in reduced 68% of DNA damage in 3T3-L1 cells.
However, Fennel exerted a lesser effect in inhibited cancer MCF-7 cells with nicotine-induced cell migration in comparison to other spices such as pepper, long pepper, and ginger.
The above differentiation was supported by the joint study led by the Avicenna Tajik State Medical University, in the evaluation of the antioxidant effect of the essential oil of fennel (Foeniculum vulgare) against MCF-7 (human breast adenocarcinoma).
According to the result from Gas chromatographic-mass spectrometric analysis, fennel displayed a moderated antioxidant in precipitated cytotoxic activity against MCF-7 (human breast adenocarcinoma) with IC50 values between 30-210 mg L-1 in comparison to cytotoxic reference compounds.
In fact, the efficacy of fennel essential oil in inhibiting breast cancer proliferation and migration was attributed to the presence of lipophilic secondary metabolites and anise aldehyde, which have the potential to elevate interference with molecular targets in cells by fennel antioxidant compounds such as anethole.
Taken together, fennel and its bioactive compound may be considered functional foods in reduced risk, progression, and treatment of breast cancer. However, intake of fennel supplements should be taken with extreme care in preventing liver acute toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Analysis and evaluation of the antimicrobial and anticancer activities of the essential oil isolated from Foeniculum vulgare from Hamedan, Iran by Akhbari M1, Kord R1, Jafari Nodooshan S2, Hamedi S3.(PubMed)
(2) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M8.(PubMed)
(3) Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration by Jayakumar R1, Kanthimathi MS.(PubMed)
Fennel may have a potential and therapeutic effect in reducing the risk and treatment of breast cancer, some scientists suggested.
Breast cancer is a medical condition characterized by cell growth disorderly and uncontrollably in the breast tissue. At the later stage, cancerous cells may travel a distance away to infect other healthy tissues and organs.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the evaluation of the essential oil extracted from fennel activity in human breast cancer cell line (MDA-Mb), researchers found that application of fennel extract exerted a significant effect in inhibition of the expression of cancer cell line at a dose of lower than flower than 10 μg/mL with IC50.
According to the University of Malaya in the investigation of the DNA protecting activity and inhibition of nicotine-induced cancer cell migration of 9 species, fennel exerted a potential effect in the protection of the DNA integrity and inhibition of nicotine-induced cancer cell migration against Murine fibroblasts (3T3-L1) and human breast cancer (MCF-7) cells pre-treated with spice extracts and then exposed to H₂O₂ and nicotine.
Additional analysis suggested that the result of inhibition was attributed to fennel antioxidants of phenols and flavonoids in ameliorated H2O2 in initiated chain activity in the induction of cytotoxicity in altered DNA of the experiment cell line.
Some researchers suggested that the overproduction of hydrogen peroxide may serve as a prodrug in the presence of transition metal ions, in the induced production of highly reactive hydroxyl radicals to initiate DNA damage in precipitated apoptosis.
In other words, the application of highly oxidative hydrogen peroxide in the breast cancer cell line may cause a significant cytotoxic effect in cancer cell death.
These results demonstrated the correlation of the increase of apoptosis with the rise in the generation of reactive oxygen species in cancer cells.
Due to this potential activity, some researchers suggested that hydrogen peroxide overproduced in tumor cells can serve as a prodrug for the treatment of cancer.
On the other hand, the application of H2O2 in healthy cells may induce DNA damage in the initiation of cancer cell development.
Furthermore, fennel scored a statistically significant DNA protecting activity in comparison to other spices, such as ginger with 50 μg/ml in reduced 68% of DNA damage in 3T3-L1 cells.
However, Fennel exerted a lesser effect in inhibited cancer MCF-7 cells with nicotine-induced cell migration in comparison to other spices such as pepper, long pepper, and ginger.
The above differentiation was supported by the joint study led by the Avicenna Tajik State Medical University, in the evaluation of the antioxidant effect of the essential oil of fennel (Foeniculum vulgare) against MCF-7 (human breast adenocarcinoma).
According to the result from Gas chromatographic-mass spectrometric analysis, fennel displayed a moderated antioxidant in precipitated cytotoxic activity against MCF-7 (human breast adenocarcinoma) with IC50 values between 30-210 mg L-1 in comparison to cytotoxic reference compounds.
In fact, the efficacy of fennel essential oil in inhibiting breast cancer proliferation and migration was attributed to the presence of lipophilic secondary metabolites and anise aldehyde, which have the potential to elevate interference with molecular targets in cells by fennel antioxidant compounds such as anethole.
Taken together, fennel and its bioactive compound may be considered functional foods in reduced risk, progression, and treatment of breast cancer. However, intake of fennel supplements should be taken with extreme care in preventing liver acute toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Analysis and evaluation of the antimicrobial and anticancer activities of the essential oil isolated from Foeniculum vulgare from Hamedan, Iran by Akhbari M1, Kord R1, Jafari Nodooshan S2, Hamedi S3.(PubMed)
(2) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M8.(PubMed)
(3) Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration by Jayakumar R1, Kanthimathi MS.(PubMed)
#Herbal #Fennel Exerts Anti-Proliferative and Apoptotic and Cytotoxic Effect on #Cancer Cells, Scientists Show
Kyle J. Norton
Scientists may have found a whole food or herb with the potential to activate the protein that programs the death of cancer cells, some studies found.
Cell death is a natural process to warrants the normal development of cells and the cell cycle maturation and maintain the normal function body in the optimized state.
However, some microorganisms are found to process the activity in triggering cell death for their own survival.
Apoptosis, or programmed cell death, is a function of the immune system that evolved as a rapid and irreversible process to efficiently eliminate dysfunctional cells, including cells that were damaged by the alternation of DNA or infection
Cancer apoptosis is an action that causes cancer cells to die off with or without affecting the nearby cells.
Some herbal medicine such as fennel was shown to induce the function of overexpression of levels of free radical in initiating a cytotoxic effect that targets cancer cells while protecting the healthy cells through its antioxidant activity.
Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
Herbal medicine has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
The study to investigate several herbal plants ethanol extracts from fruits of their apoptotic activity from fruits of seven species of Apiaceae family, namely, Eryngium planum, Archangelica officinalis, Pastinaca sativa, Heracleum sibiricum, Carum carvi, Foeniculum vulgare (fennel), and Levisticum officinale against ML-1—human acute myeloblastic leukemia, J-45.01—human acute T cell leukemia, EOL—human eosinophilic leukemia, HL-60—human Caucasian promyelocytic leukemia, 1301—human T cell leukemia lymphoblast, C-8166—human T cell leukemia, U-266B1—human myeloma, WICL—human Caucasian normal B cell, and H-9—human T cell, researchers found that
* The ethanol extract from fruit F. Vulgare shows the highest mortality in the Trypan blue test for the J45 cell line with 4% of viable cells and a C8166 cell line with 100% mortality.
* The extract also shows the highest viability in other cell lines, including the HL60 at 60%, EOL at 48%, and ML1 at 42%. The normal cell line H9 and WICL showed 35% and 25% of viable cells, respectively.
Furthermore, the reaffirm the use of fennel in traditional cancer treatment, researchers at the King Abdulaziz University (KAU), launched a study to demonstrate the anti-proliferative and apoptotic effect of chloroform fraction of fennel (CFF) in MCF-7 cells.
Application of fennel was shown to inhibit the growth against MCF-7 and MDA-MB-237 in time- and concentration-dependent manners.
Fennel-induced apoptosis of around 49% at the doses of 0.5 mg/ml of CFF and PI-stained cells showed the G1 phase cell cycle arrest, according to the Annexin V/PI assay.
More importantly, the application of fennel also was found to reduce the elevated levels of ROS, disrupted mitochondrial membrane and increased levels of caspase-9 & caspase-3, and DNA fragmentation in the promotion of MCF-7 cell death. experiment
Dr. Syed FQ, the lead author in the final assessment of the experiment said, "(The results) revealed the proliferation inhibition, cell cycle arrest and apoptosis induction effect of CFF, which may help in exploring the novel anti-cancer drug for therapeutic implications".
Moreover, in the study to examine whether anethole, a major bioactive compound found in fennel, anise, and camphor processes anti-metastatic and apoptotic effects on highly-metastatic HT-1080 human fibrosarcoma tumor cells, researchers found that
* Despite weak cytotoxicity against HT-1080 cells, anethole inhibits the adhesion to Matrigel and invasion of HT-1080 cells in a dose-dependent manner.
* Anethole is also able to down-regulate the expression of matrix metalloproteinase (MMP)-2 and -9 with anti-apoptotic function and up-regulate the gene expression of tissue inhibitor of metalloproteinase (TIMP)-1 with apoptotic function.
Finally, anethole significantly decreased mRNA expression of urokinase plasminogen activator (uPA), but not uPA receptor (uPAR) in the facilitated cancer cell death.
Taken all together, fennel alone or its extracts and bioactive compound anethole may be considered adjunct therapy combined with conventional medicine for the treatment of cancers
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar, Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chloroform fraction of Foeniculum vulgare induced ROS mediated, mitochondria-caspase-dependent apoptotic pathway in MCF-7, human breast cancer cell line by Syed FQ1, Elkady AI2, Mohammed FA3, Mirza MB4, Hakeem KR5, Alkarim S(PubMed)
(3) Anethole exerts antimetastatic activity via inhibition of matrix metalloproteinase 2/9 and AKT/mitogen-activated kinase/nuclear factor kappa B signaling pathways by Choo EJ1, Rhee YH, Jeong SJ, Lee HJ, Kim HS, Ko HS, Kim JH, Kwon TR, Jung JH, Kim JH, Lee HJ, Lee EO, Kim DK, Chen CY, Kim SH(PubMed)
Scientists may have found a whole food or herb with the potential to activate the protein that programs the death of cancer cells, some studies found.
Cell death is a natural process to warrants the normal development of cells and the cell cycle maturation and maintain the normal function body in the optimized state.
However, some microorganisms are found to process the activity in triggering cell death for their own survival.
Apoptosis, or programmed cell death, is a function of the immune system that evolved as a rapid and irreversible process to efficiently eliminate dysfunctional cells, including cells that were damaged by the alternation of DNA or infection
Cancer apoptosis is an action that causes cancer cells to die off with or without affecting the nearby cells.
Some herbal medicine such as fennel was shown to induce the function of overexpression of levels of free radical in initiating a cytotoxic effect that targets cancer cells while protecting the healthy cells through its antioxidant activity.
Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
Herbal medicine has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
The study to investigate several herbal plants ethanol extracts from fruits of their apoptotic activity from fruits of seven species of Apiaceae family, namely, Eryngium planum, Archangelica officinalis, Pastinaca sativa, Heracleum sibiricum, Carum carvi, Foeniculum vulgare (fennel), and Levisticum officinale against ML-1—human acute myeloblastic leukemia, J-45.01—human acute T cell leukemia, EOL—human eosinophilic leukemia, HL-60—human Caucasian promyelocytic leukemia, 1301—human T cell leukemia lymphoblast, C-8166—human T cell leukemia, U-266B1—human myeloma, WICL—human Caucasian normal B cell, and H-9—human T cell, researchers found that
* The ethanol extract from fruit F. Vulgare shows the highest mortality in the Trypan blue test for the J45 cell line with 4% of viable cells and a C8166 cell line with 100% mortality.
* The extract also shows the highest viability in other cell lines, including the HL60 at 60%, EOL at 48%, and ML1 at 42%. The normal cell line H9 and WICL showed 35% and 25% of viable cells, respectively.
Furthermore, the reaffirm the use of fennel in traditional cancer treatment, researchers at the King Abdulaziz University (KAU), launched a study to demonstrate the anti-proliferative and apoptotic effect of chloroform fraction of fennel (CFF) in MCF-7 cells.
Application of fennel was shown to inhibit the growth against MCF-7 and MDA-MB-237 in time- and concentration-dependent manners.
Fennel-induced apoptosis of around 49% at the doses of 0.5 mg/ml of CFF and PI-stained cells showed the G1 phase cell cycle arrest, according to the Annexin V/PI assay.
More importantly, the application of fennel also was found to reduce the elevated levels of ROS, disrupted mitochondrial membrane and increased levels of caspase-9 & caspase-3, and DNA fragmentation in the promotion of MCF-7 cell death. experiment
Dr. Syed FQ, the lead author in the final assessment of the experiment said, "(The results) revealed the proliferation inhibition, cell cycle arrest and apoptosis induction effect of CFF, which may help in exploring the novel anti-cancer drug for therapeutic implications".
Moreover, in the study to examine whether anethole, a major bioactive compound found in fennel, anise, and camphor processes anti-metastatic and apoptotic effects on highly-metastatic HT-1080 human fibrosarcoma tumor cells, researchers found that
* Despite weak cytotoxicity against HT-1080 cells, anethole inhibits the adhesion to Matrigel and invasion of HT-1080 cells in a dose-dependent manner.
* Anethole is also able to down-regulate the expression of matrix metalloproteinase (MMP)-2 and -9 with anti-apoptotic function and up-regulate the gene expression of tissue inhibitor of metalloproteinase (TIMP)-1 with apoptotic function.
Finally, anethole significantly decreased mRNA expression of urokinase plasminogen activator (uPA), but not uPA receptor (uPAR) in the facilitated cancer cell death.
Taken all together, fennel alone or its extracts and bioactive compound anethole may be considered adjunct therapy combined with conventional medicine for the treatment of cancers
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar, Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chloroform fraction of Foeniculum vulgare induced ROS mediated, mitochondria-caspase-dependent apoptotic pathway in MCF-7, human breast cancer cell line by Syed FQ1, Elkady AI2, Mohammed FA3, Mirza MB4, Hakeem KR5, Alkarim S(PubMed)
(3) Anethole exerts antimetastatic activity via inhibition of matrix metalloproteinase 2/9 and AKT/mitogen-activated kinase/nuclear factor kappa B signaling pathways by Choo EJ1, Rhee YH, Jeong SJ, Lee HJ, Kim HS, Ko HS, Kim JH, Kwon TR, Jung JH, Kim JH, Lee HJ, Lee EO, Kim DK, Chen CY, Kim SH(PubMed)
#Healthyfood #ManukaHoney Significantly Decreases the Ulcer Index and Preserves the Gastric Mucosal Glycoprotein, According to Studies
Kyle J. Norton
Scientists may have found natural alternative antibiotics for the treatment of stomach ulcers caused by a bacterial infection, some studies found.
A stomach/Gastric ulcer is a condition characterized by the breaking in the tissue lining of the stomach.
Most cases of stomach ulcers are caused by the infection with the Helicobacter pylori bacterium or long-term intake of anti-inflammatory medication.
The most common symptoms of stomach ulcers include a dull pain in the stomach and gastrointestinal discomforts such as nausea or vomiting. bloating, burping, or burning sensation in the chest.
If you are experiencing some of the above symptoms persistently, please check with your doctor to rule out the possibility of a stomach ulcer.
Unless the disease is caused by medication, most stomach ulcers can be treated successfully with the use of antibiotics and medications that reduce the overproduction of stomach acid.
Some researchers suggested that people who are obese are also susceptible to the onset of stomach ulcers due to the following reasons
* Epidemiological findings suggested that obesity is associated with inflammation in the gut, leading to the weakness of gut cells that are prone to ulcer formation.
* Obesity has been found to have an unhealthy ratio of gut bacteria.
* Overexpression of gut harmful bacteria increases the risk of toxin accumulation in the lining of the gut.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.
Researchers on finding a natural compound for the treatment of stomach ulcers investigated the Manuka honey antiulcer activity in gastric rats.
Ethanol-induced gastric ulcers in rats selected for the study were divided into control, ethanol (ulcer), omeprazole, and manuka honey groups.
Injection of Manuka honey significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein through the increased expression of gastric mucosal levels of nitric oxide (NO) in the inhibition of leukocyte adherence to the endothelium, and antioxidant enzymes glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD).
Furthermore, Manuka honey also decreased gastric mucosal MDA, the oxidative stress marker, and proinflammatory expression in the stomach caused by the injection of ethanol (ulcer), and omeprazole.
Dr. the lead scientist wrote, "Manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and non-enzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels".
The findings clearly suggested Manuka honey inhibited stomach ulcers by modulating oxidative stress, proinflammatory cytokines, and antioxidant expression.
In order to reveal more information about the honey antiulcer activity, researchers evaluated the use of Manuka honey in the treatment of acetic acid-induced chronic gastric ulcers in rats.
The study included rats treated with three different concentrations of honey. Treatment with manuka honey was found to significantly reduce the ulcer index and maintain the glycoprotein content.
Manuka injection also reduced the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF-α, IL-1β, and IL-6) as compared to the untreated control group.
Honey-treated groups showed a significant increase in enzymatic (GPx and SOD) and non-enzymatic (GSH) antioxidants besides levels of the anti-inflammatory cytokine IL-10, similar to that of the previous study.
More importantly, manuka honey-treated animals not only normalized cell cycle distribution but also significantly lowered apoptosis in gastric mucosa.
The results indicated that manuka honey is effective for the treatment of chronic ulcers through many mechanisms.
Taken together, Manuka honey may be considered a functioning remedy for the prevention and combined with primary medicine for the treatment of stomach ulcers with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Saad B. Almasaudi, 1 Nagla A. El-Shitany, 2, 3 Aymn T. Abbas, 4, 5 Umama A. Abdel-Dayem, 6Soad S. Ali, 7 Soad K. Al Jaouni, 8 and Steve Harakeh. (PMC)
(2) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
(3) Association of peptic ulcer disease with obesity, nutritional components, and blood parameters in the Korean population by Jihye Kim, Keun Ho Kim, and Bum Ju Lee. (PMC)
Scientists may have found natural alternative antibiotics for the treatment of stomach ulcers caused by a bacterial infection, some studies found.
A stomach/Gastric ulcer is a condition characterized by the breaking in the tissue lining of the stomach.
Most cases of stomach ulcers are caused by the infection with the Helicobacter pylori bacterium or long-term intake of anti-inflammatory medication.
The most common symptoms of stomach ulcers include a dull pain in the stomach and gastrointestinal discomforts such as nausea or vomiting. bloating, burping, or burning sensation in the chest.
If you are experiencing some of the above symptoms persistently, please check with your doctor to rule out the possibility of a stomach ulcer.
Unless the disease is caused by medication, most stomach ulcers can be treated successfully with the use of antibiotics and medications that reduce the overproduction of stomach acid.
Some researchers suggested that people who are obese are also susceptible to the onset of stomach ulcers due to the following reasons
* Epidemiological findings suggested that obesity is associated with inflammation in the gut, leading to the weakness of gut cells that are prone to ulcer formation.
* Obesity has been found to have an unhealthy ratio of gut bacteria.
* Overexpression of gut harmful bacteria increases the risk of toxin accumulation in the lining of the gut.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of the healthy sweet foods for replacing the use of white sugar and artificial sweeteners by many people.
Researchers on finding a natural compound for the treatment of stomach ulcers investigated the Manuka honey antiulcer activity in gastric rats.
Ethanol-induced gastric ulcers in rats selected for the study were divided into control, ethanol (ulcer), omeprazole, and manuka honey groups.
Injection of Manuka honey significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein through the increased expression of gastric mucosal levels of nitric oxide (NO) in the inhibition of leukocyte adherence to the endothelium, and antioxidant enzymes glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD).
Furthermore, Manuka honey also decreased gastric mucosal MDA, the oxidative stress marker, and proinflammatory expression in the stomach caused by the injection of ethanol (ulcer), and omeprazole.
Dr. the lead scientist wrote, "Manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and non-enzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels".
The findings clearly suggested Manuka honey inhibited stomach ulcers by modulating oxidative stress, proinflammatory cytokines, and antioxidant expression.
In order to reveal more information about the honey antiulcer activity, researchers evaluated the use of Manuka honey in the treatment of acetic acid-induced chronic gastric ulcers in rats.
The study included rats treated with three different concentrations of honey. Treatment with manuka honey was found to significantly reduce the ulcer index and maintain the glycoprotein content.
Manuka injection also reduced the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF-α, IL-1β, and IL-6) as compared to the untreated control group.
Honey-treated groups showed a significant increase in enzymatic (GPx and SOD) and non-enzymatic (GSH) antioxidants besides levels of the anti-inflammatory cytokine IL-10, similar to that of the previous study.
More importantly, manuka honey-treated animals not only normalized cell cycle distribution but also significantly lowered apoptosis in gastric mucosa.
The results indicated that manuka honey is effective for the treatment of chronic ulcers through many mechanisms.
Taken together, Manuka honey may be considered a functioning remedy for the prevention and combined with primary medicine for the treatment of stomach ulcers with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Saad B. Almasaudi, 1 Nagla A. El-Shitany, 2, 3 Aymn T. Abbas, 4, 5 Umama A. Abdel-Dayem, 6Soad S. Ali, 7 Soad K. Al Jaouni, 8 and Steve Harakeh. (PMC)
(2) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
(3) Association of peptic ulcer disease with obesity, nutritional components, and blood parameters in the Korean population by Jihye Kim, Keun Ho Kim, and Bum Ju Lee. (PMC)
Friday, 25 August 2023
#Ginger's 6-#Gingerol Processes Anti-Oral Cancer Properties, Researchers Say
Kyle J. Norton
Scientists may have found a natural remedy for the prevention and treatment of oral cancer with no side effects, according to studies.
Oral cancer also known as mouth cancer is a medical condition characterized by irregular cell growth in the tissue of the oral cavity, due to the alternation of cell DNA.
Most cases of oral cancer begin in the cells on the surface of the inner lining of oral tissue.
However, at the advanced stage, oral cancer cells can travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.
According to the statistic provided by the American Cancer Society, in 2018, approximately 51,540 people were diagnosed with oral cavity or oropharyngeal cancer. The disease causes the death of an estimated 10,030 people.
The 5-year survival rate of oral cancer is 66%, including all stages.
Family history, smoking, alcohol drinking, infection by the HPV virus, poor hygiene, and genetic preposition are some of the risk factors associated with the disease.
Some researchers suggested that oral sex may be one of the major prevalent risk factors involved in the development of oral cancer. Dr. Rajiv Saini in the examination of the connection between oral sex and oral cancer, wrote, "The diverse conduit in the oral cavity that provides as a gateway of exposure of infection from the oral cavity to bloodstream include any open sores, cuts, abrasions, or bleeding gum disease such as gingivitis and periodontitis".
"Accumulating molecular and pathologic evidence has strengthened the hypothesis that HPV infection could play a role in the etiology of some oral squamous cell carcinomas.
And, "To reduce the risk of infection during unprotected oral sex, limit exposure to sexual fluids and ensure that no cuts or lesions are present in the mouth or on the genitals. Good oral health, free from bleeding gums, lip sores, cuts, broken skin, and oral epithelium, enormously reduces the chances of transmission of infection among the partners indulging in oral sex".
These results strongly suggested people who perform oral sex before, during, and after sexual intercourse may be at risk of oral cancer due to being infected by the HPV virus.
Researchers to find a natural compound for the inhibition of oral cancer examined the [6]-Shogaol ([6]-SHO), a major constituent of ginger anti-tumor activity.
[6]-SHO showed a significant effect in preventing oral squamous cell carcinoma by activating proapoptotic factors in vitro and in vivo experimental models.
In the inflammation and cell proliferation assays, injection of [6]-SHO inhibited the oral cancer cell line through cytotoxicity induced by the expression of proinflammatory cytokines, proteins associated with cell apoptosis, and anti-cell survival mechanisms.
Furthermore, in the oral cancer cells, oral administration of [6]-SHO strongly inhibited phosphorylation in stimulating the enzymes that carry energy to the cancer cells and enzymes in the degradation of cellular response to inflammation.
Dr. Annamalai G, the lead scientist said, " [6]-SHO is a novel functional agent capable of preventing DMBA-induced inflammation and cell proliferation-associated tumorigenesis by modulating multiple signaling molecules".
Additionally, in order to reveal more information about 6-Gingerol anti-oral cancer properties, researchers investigated the compound in human oral (SCC4, KB) with or without wortmannin, rapamycin, and cisplatin.
6-Gingerol showed dose-dependent cytotoxicity in the oral cell line.
Combinations of 6-gingerol with wortmannin and cisplatin showed additive effects, while rapamycin, it showed 50% cytotoxicity equivalent to that of IC50 of 6-gingerol alone.
Treatment with 6-gingerol exhibited S-phase arrest in SCC4 cells. But 6-Gingerol, wortmannin, and rapamycin treatment showed almost two-fold higher expression of proteins associated with cancer cell apoptosis.
Dr. in the final report wrote," 6-gingerol appears to be a safe and potent chemotherapeutic/chemopreventive compound acting through cell cycle arrest and induction of apoptosis in human oral....cells".
Taken together, ginger processed bioactive ingredient 6-gingerol and [6]-Shogaol may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of oral cancer, pending the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) [6]-Shogaol attenuates inflammation, and cell proliferation via modulating NF-κB and AP-1 oncogenic signaling in 7,12-dimethylbenz[a] anthracene-induced oral carcinogenesis by Annamalai G1, Suresh K. (PubMed)
(2) 6-Gingerol Mediates its Anti-Tumor Activities in Human Oral and Cervical Cancer Cell Lines through Apoptosis and Cell Cycle Arrest by Kapoor V1, Aggarwal S1, Das SN. (PubMed)
(3) Oral sex and oral cancer: A virus link by Rajiv Saini. (PMC)
Scientists may have found a natural remedy for the prevention and treatment of oral cancer with no side effects, according to studies.
Oral cancer also known as mouth cancer is a medical condition characterized by irregular cell growth in the tissue of the oral cavity, due to the alternation of cell DNA.
Most cases of oral cancer begin in the cells on the surface of the inner lining of oral tissue.
However, at the advanced stage, oral cancer cells can travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.
According to the statistic provided by the American Cancer Society, in 2018, approximately 51,540 people were diagnosed with oral cavity or oropharyngeal cancer. The disease causes the death of an estimated 10,030 people.
The 5-year survival rate of oral cancer is 66%, including all stages.
Family history, smoking, alcohol drinking, infection by the HPV virus, poor hygiene, and genetic preposition are some of the risk factors associated with the disease.
Some researchers suggested that oral sex may be one of the major prevalent risk factors involved in the development of oral cancer. Dr. Rajiv Saini in the examination of the connection between oral sex and oral cancer, wrote, "The diverse conduit in the oral cavity that provides as a gateway of exposure of infection from the oral cavity to bloodstream include any open sores, cuts, abrasions, or bleeding gum disease such as gingivitis and periodontitis".
"Accumulating molecular and pathologic evidence has strengthened the hypothesis that HPV infection could play a role in the etiology of some oral squamous cell carcinomas.
And, "To reduce the risk of infection during unprotected oral sex, limit exposure to sexual fluids and ensure that no cuts or lesions are present in the mouth or on the genitals. Good oral health, free from bleeding gums, lip sores, cuts, broken skin, and oral epithelium, enormously reduces the chances of transmission of infection among the partners indulging in oral sex".
These results strongly suggested people who perform oral sex before, during, and after sexual intercourse may be at risk of oral cancer due to being infected by the HPV virus.
Researchers to find a natural compound for the inhibition of oral cancer examined the [6]-Shogaol ([6]-SHO), a major constituent of ginger anti-tumor activity.
[6]-SHO showed a significant effect in preventing oral squamous cell carcinoma by activating proapoptotic factors in vitro and in vivo experimental models.
In the inflammation and cell proliferation assays, injection of [6]-SHO inhibited the oral cancer cell line through cytotoxicity induced by the expression of proinflammatory cytokines, proteins associated with cell apoptosis, and anti-cell survival mechanisms.
Furthermore, in the oral cancer cells, oral administration of [6]-SHO strongly inhibited phosphorylation in stimulating the enzymes that carry energy to the cancer cells and enzymes in the degradation of cellular response to inflammation.
Dr. Annamalai G, the lead scientist said, " [6]-SHO is a novel functional agent capable of preventing DMBA-induced inflammation and cell proliferation-associated tumorigenesis by modulating multiple signaling molecules".
Additionally, in order to reveal more information about 6-Gingerol anti-oral cancer properties, researchers investigated the compound in human oral (SCC4, KB) with or without wortmannin, rapamycin, and cisplatin.
6-Gingerol showed dose-dependent cytotoxicity in the oral cell line.
Combinations of 6-gingerol with wortmannin and cisplatin showed additive effects, while rapamycin, it showed 50% cytotoxicity equivalent to that of IC50 of 6-gingerol alone.
Treatment with 6-gingerol exhibited S-phase arrest in SCC4 cells. But 6-Gingerol, wortmannin, and rapamycin treatment showed almost two-fold higher expression of proteins associated with cancer cell apoptosis.
Dr. in the final report wrote," 6-gingerol appears to be a safe and potent chemotherapeutic/chemopreventive compound acting through cell cycle arrest and induction of apoptosis in human oral....cells".
Taken together, ginger processed bioactive ingredient 6-gingerol and [6]-Shogaol may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of oral cancer, pending the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) [6]-Shogaol attenuates inflammation, and cell proliferation via modulating NF-κB and AP-1 oncogenic signaling in 7,12-dimethylbenz[a] anthracene-induced oral carcinogenesis by Annamalai G1, Suresh K. (PubMed)
(2) 6-Gingerol Mediates its Anti-Tumor Activities in Human Oral and Cervical Cancer Cell Lines through Apoptosis and Cell Cycle Arrest by Kapoor V1, Aggarwal S1, Das SN. (PubMed)
(3) Oral sex and oral cancer: A virus link by Rajiv Saini. (PMC)
#Phytochemical #Betanin Inhibits Diseases Associated with #Oxidativestress, According to Studies
Kyle J. Norton
Antioxidants are stable atoms that inhibit oxidation caused by free radicals.
Free radical scavengers are types of antioxidants that inhibit free radicals before they can orchestrate a chain reaction that can not be stopped until all electrons in the outermost ring are paired or inhibited by antioxidants.
Oxidative stress is associated with chronic disease due to the imbalanced ratio of free radicals and antioxidants produced by the host including heart disease, stroke, and diabetes.
Antioxidants besides being produced by the body, they can also come into the body's dietary sources.
In a healthy individual, an antioxidant produced by the body is good enough to counter the expression of free radicals induced by cell metabolism and free radicals induced by the environment such as the air we breathe and the food we eat.
However, for people with a weakened immune system, intake of antioxidants from outside sources such as fruits and vegetables can be helpful.
Believe it or not. moderate free radicals in the body are necessary for body functioning, including the promotion of heart function in blood circulation.
Most common types of free radical scavengers include
* Catalases, the very important enzyme is produced by the host that protects the cell from oxidative damage by free radicals.
*Glutathione peroxidase, is a cytosolic enzyme produced by the host that dissolves hydrogen peroxide to water and oxygen and peroxide radicals to alcohols and oxygen.
*Superoxide dismutase (SOD), is also produced by the host that dissolves superoxide radicals into either ordinary molecular oxygen or hydrogen peroxide.
*Vitamin E, Vitamin C, and vitamin D.
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In the urgency to find a natural compound for the treatment of diseases associated with overexpression of free radicals, researchers examined the betanin free radical scavenging activity.
According to the Trolox equivalent antioxidant capacity (TEAC) assay, at a pH > 4, betanin is about 1.5-2.0-fold more active to scavenge free radicals compared to those of anthocyanins.
More precisely, the exceptionally high antioxidant activity of betanin was associated with an increase of its H-donation and electron-donation ability, totally depending on the expression of cationic state to mono-, di- and tri-deprotonated states present at basic solutions.
In other words, the efficacy of betanin's high free radical scavenging activity was dependent on the levels of pH.
Taken together, betanin may be considered supplements for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best bBest Beforenews, the karateKarateily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorShorty Awardr last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin, the main pigment of red beet: molecular origin of its exceptionally high free radical-scavenging activity by Gliszczyńska-Swigło A1, Szymusiak H, Malinowska P. (PubMed)
(2) Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes by Tesoriere L1, Allegra M, Gentile C, Livrea MA. (PubMed)
Antioxidants are stable atoms that inhibit oxidation caused by free radicals.
Free radical scavengers are types of antioxidants that inhibit free radicals before they can orchestrate a chain reaction that can not be stopped until all electrons in the outermost ring are paired or inhibited by antioxidants.
Oxidative stress is associated with chronic disease due to the imbalanced ratio of free radicals and antioxidants produced by the host including heart disease, stroke, and diabetes.
Antioxidants besides being produced by the body, they can also come into the body's dietary sources.
In a healthy individual, an antioxidant produced by the body is good enough to counter the expression of free radicals induced by cell metabolism and free radicals induced by the environment such as the air we breathe and the food we eat.
However, for people with a weakened immune system, intake of antioxidants from outside sources such as fruits and vegetables can be helpful.
Believe it or not. moderate free radicals in the body are necessary for body functioning, including the promotion of heart function in blood circulation.
Most common types of free radical scavengers include
* Catalases, the very important enzyme is produced by the host that protects the cell from oxidative damage by free radicals.
*Glutathione peroxidase, is a cytosolic enzyme produced by the host that dissolves hydrogen peroxide to water and oxygen and peroxide radicals to alcohols and oxygen.
*Superoxide dismutase (SOD), is also produced by the host that dissolves superoxide radicals into either ordinary molecular oxygen or hydrogen peroxide.
*Vitamin E, Vitamin C, and vitamin D.
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In the urgency to find a natural compound for the treatment of diseases associated with overexpression of free radicals, researchers examined the betanin free radical scavenging activity.
According to the Trolox equivalent antioxidant capacity (TEAC) assay, at a pH > 4, betanin is about 1.5-2.0-fold more active to scavenge free radicals compared to those of anthocyanins.
More precisely, the exceptionally high antioxidant activity of betanin was associated with an increase of its H-donation and electron-donation ability, totally depending on the expression of cationic state to mono-, di- and tri-deprotonated states present at basic solutions.
In other words, the efficacy of betanin's high free radical scavenging activity was dependent on the levels of pH.
Taken together, betanin may be considered supplements for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best bBest Beforenews, the karateKarateily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorShorty Awardr last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin, the main pigment of red beet: molecular origin of its exceptionally high free radical-scavenging activity by Gliszczyńska-Swigło A1, Szymusiak H, Malinowska P. (PubMed)
(2) Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes by Tesoriere L1, Allegra M, Gentile C, Livrea MA. (PubMed)
#Honey Is Effective to Shortens the Duration of Bacterial Diarrhea, Researchers Say
Kyle J. Norton
Scientists may have found a natural alternative for the treatment of diarrhea, according to studies.
Diarrhea is a condition of loose, watery stools. Acute diarrhea is a common problem in North America that lasts for a very short time.
However, chronic diarrhea can be worrisome. The most common causes of chronic diarrhea are diseases associated with the gastrointestinal tract, including irritable bowel syndrome (IBS), inflammatory bowel disease (Crohn's disease and ulcerative colitis), and malabsorption syndromes.
According to the statistics, acute diarrhea is one of the most common causes of death among children younger than 5 years old worldwide.
The disease is associated mostly in countries with poor environmental sanitation, inadequate water supplies, and poverty.
There are many risk factors involved in the onset of the syndrome, including demography, socio-economy, poor water supply, poor sanitation, poor hygiene practices, breastfeeding, and malnutrition.
Some researchers suggested that a severely weakened immune system such as the use of immune-suppressive medicine and the elderly may also be at a higher risk of diarrhea.
Dr. Bouchaud O in examining the risk of immune deficiency and diarrhea wrote, "With a prevalence of approximatively 50%, diarrhea is a frequent event in an immune deficiency of any cause".
And "Gram-negative infections and Clostridium difficile colitis have to be diagnosed because efficient treatment is available. In these patients usually in bad general condition, because diarrhea is often of unknown etiology or noncurable, the diagnostic and therapeutic strategy must be pragmatic to control the symptoms without an excess of invasive procedures".
These results clearly suggested that if you have a severely weakened immune system, you are at higher risk of bacterial-infected diarrhea.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.
Researchers searching for a natural compound to treat diarrhea evaluated the honey gastroprotective effect against diarrhea.
Injection of honey induced a significant reduction in the duration of bacterial diarrhea, and it worked well as a substitute for glucose in an oral rehydration solution containing electrolytes.
In nonbacterial gastroenteritis, honey exerted a similar effect as glucose on the duration of diarrhea.
In an array of gram-positive and gram-negative bacteria, most pathogenic bacteria failed to grow in honey at a concentration of 40% and above, similar to those studies of honey on Staphylococcus aureus, Proteus mirabilis, and Candida albicans failed to grow in the presence of undiluted honey in vitro experiments.
Honey-agar all intestinal bacterial pathogens failed to grow at a concentration of 40% and above of pure honey, compared to those of bacteria in control plates and different growth media.
Scientists wrote in the final report, "Findings from studies on honey have thus shown that when given with an ORS it shortens the duration of bacterial diarrhea and may safely be used as a substitute for glucose, provided that the solution contains electrolytes".
In order to reveal more information about honey anti-diarrhea activity, researchers examined the honey on diarrhea and fecal microbiota in critically ill patients.
The double-blind, randomized controlled single-center study, included 32 patients randomly selected to receive a high protein kitchen enteral diet or honey as 10% of their carbohydrate intake.
The treatment group showed an insignificant increase in the frequency of bifidobacterium DNA by study day 7 in comparison with the control group and a considerable reduction in diarrhea.
Honey group also reduced the length of the Intensive Care Unit and the development of organ failure in critically ill patients.
Taken together, honey may be considered a functional remedy for the prevention and treatment of diarrhea, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Honey: its antibacterial action in the treatment of gastroenteritis.[No authors listed]. (PubMed)
(2) Effect of Honey on Diarrhea and Fecal Microbiotain in Critically Ill Tube-Fed Patients: A Single Center Randomized Controlled Study by Zahra Vahdat Shariatpanahi,1 Fatemeh Jamshidi,1 Javad Nasrollahzadeh,1 Zohreh Amiri,1 and human Teymourian. (PubMed)
(3) [Diarrhea in immune deficiency status].[Article in French] by Bouchaud O. (PubMed)
Scientists may have found a natural alternative for the treatment of diarrhea, according to studies.
Diarrhea is a condition of loose, watery stools. Acute diarrhea is a common problem in North America that lasts for a very short time.
However, chronic diarrhea can be worrisome. The most common causes of chronic diarrhea are diseases associated with the gastrointestinal tract, including irritable bowel syndrome (IBS), inflammatory bowel disease (Crohn's disease and ulcerative colitis), and malabsorption syndromes.
According to the statistics, acute diarrhea is one of the most common causes of death among children younger than 5 years old worldwide.
The disease is associated mostly in countries with poor environmental sanitation, inadequate water supplies, and poverty.
There are many risk factors involved in the onset of the syndrome, including demography, socio-economy, poor water supply, poor sanitation, poor hygiene practices, breastfeeding, and malnutrition.
Some researchers suggested that a severely weakened immune system such as the use of immune-suppressive medicine and the elderly may also be at a higher risk of diarrhea.
Dr. Bouchaud O in examining the risk of immune deficiency and diarrhea wrote, "With a prevalence of approximatively 50%, diarrhea is a frequent event in an immune deficiency of any cause".
And "Gram-negative infections and Clostridium difficile colitis have to be diagnosed because efficient treatment is available. In these patients usually in bad general condition, because diarrhea is often of unknown etiology or noncurable, the diagnostic and therapeutic strategy must be pragmatic to control the symptoms without an excess of invasive procedures".
These results clearly suggested that if you have a severely weakened immune system, you are at higher risk of bacterial-infected diarrhea.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one healthy sweet food for replacing the use of white sugar and artificial sweeteners by many people.
Researchers searching for a natural compound to treat diarrhea evaluated the honey gastroprotective effect against diarrhea.
Injection of honey induced a significant reduction in the duration of bacterial diarrhea, and it worked well as a substitute for glucose in an oral rehydration solution containing electrolytes.
In nonbacterial gastroenteritis, honey exerted a similar effect as glucose on the duration of diarrhea.
In an array of gram-positive and gram-negative bacteria, most pathogenic bacteria failed to grow in honey at a concentration of 40% and above, similar to those studies of honey on Staphylococcus aureus, Proteus mirabilis, and Candida albicans failed to grow in the presence of undiluted honey in vitro experiments.
Honey-agar all intestinal bacterial pathogens failed to grow at a concentration of 40% and above of pure honey, compared to those of bacteria in control plates and different growth media.
Scientists wrote in the final report, "Findings from studies on honey have thus shown that when given with an ORS it shortens the duration of bacterial diarrhea and may safely be used as a substitute for glucose, provided that the solution contains electrolytes".
In order to reveal more information about honey anti-diarrhea activity, researchers examined the honey on diarrhea and fecal microbiota in critically ill patients.
The double-blind, randomized controlled single-center study, included 32 patients randomly selected to receive a high protein kitchen enteral diet or honey as 10% of their carbohydrate intake.
The treatment group showed an insignificant increase in the frequency of bifidobacterium DNA by study day 7 in comparison with the control group and a considerable reduction in diarrhea.
Honey group also reduced the length of the Intensive Care Unit and the development of organ failure in critically ill patients.
Taken together, honey may be considered a functional remedy for the prevention and treatment of diarrhea, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the karate GB daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Honey: its antibacterial action in the treatment of gastroenteritis.[No authors listed]. (PubMed)
(2) Effect of Honey on Diarrhea and Fecal Microbiotain in Critically Ill Tube-Fed Patients: A Single Center Randomized Controlled Study by Zahra Vahdat Shariatpanahi,1 Fatemeh Jamshidi,1 Javad Nasrollahzadeh,1 Zohreh Amiri,1 and human Teymourian. (PubMed)
(3) [Diarrhea in immune deficiency status].[Article in French] by Bouchaud O. (PubMed)
Subscribe to:
Posts (Atom)