Dietary #Lycopene Reduces The Risk of #CardiovascularDisease Particularly in #CoronaryHeartDisease (CHD), Researchers Say

Kyle J. Norton


Cardiovascular disease (CVD) is a group of diseases associated with blood vessels and heart muscle. Depending on the location of heart muscle damage or the blood vessel blockage, CVD can be a coronary artery disease caused by the hardening of the arteries that interfere with the blood flow to the heart.

Heart failure, a major health problem associated with the reduced function of the heart, is a leading cause of hospitalization in people older than age 65. Believe it or not, more than 6.5 million Americans are living with the condition of heart failure.

According to the statistics provided by the CDC, every year, heart disease causes the death of 610,000 people in the US. More precisely, 1 in every 4 deaths in the US every year are caused by heart disease.

Furthermore, every year about 735,000 Americans have a heart attack including the first attack of 525,000 patients.

The exact causes of cardiovascular disease are not clear. However, epidemiologically family history, age ethnicity, gender, and medical conditions such as cholesterol high blood pressure, and diabetes have been found in most patients with CVD.

Some researchers who examined the correlation between a high-fat diet and cardiovascular disease in obese patients suggested that the promotion of a high-fat diet over the past few decades may be one major culprit that causes the onset of CVD.

Dr. Jane E. Freedman wrote, " According to the National Center for Health Statistics (1999), 61% of adults in the U.S. are overweight (body mass index [BMI] 25 to 29.9 kg/m2), and 26% are obese (BMI ≥30 kg/m2). Elevated BMI, particularly caused by abdominal or upper-body obesity, has been associated with diseases and metabolic abnormalities including hyperinsulinemia, insulin resistance, type 2 diabetes, hypertension, dyslipidemia, and coronary heart disease.".

And, " clearly established diseases associated with high-fat or high-calorie diets can be offset by the use of nutritional supplements. Although these findings beckon us to draw broader implications, even if proven true in larger studies, it is doubtful that this will lead to a recommendation of high-calorie, high-fat diets".

Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In finding a natural compound for the prevention of cardiovascular disease, researchers examined the effect of lycopene by a meta-analysis.

According to the 14 studies identified by the search in the medical literature of the database of Pubmed, Embase, and Web of Science from inception to October 2016,* Lycopene exerted a significant inverse association with a pooled risk ratio (RR) of 0.83 in the risk of CVD.

* Furthermore, dietary lycopene intake was statistically significant in the reduction of risk of coronary heart disease (CHD) with an RR of 0.87 and stroke with an RR of 0.83.

* Lycopene biomarker concentrations were also inversely associated with the risk of CVD.

Based on the findings, researchers wrote in the final report, "Higher lycopene exposure is inversely associated with a lower risk of CVD".

Taken together, lycopene found in tomatoes may be considered a supplement for the prevention and treatment of CVD, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best Before It's News, the Karate GB Daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene Deficiency in Ageing and Cardiovascular Disease by Petyaev IM. (PubMed)
(2) Lycopene and risk of cardiovascular diseases: A meta-analysis of observational studies by Song B1, Liu K1, Gao Y1, Zhao L1, Fang H1, Li Y1, Pei L1, Xu Y. (PubMed)

(2) High-fat diets and cardiovascular disease. Are nutritional supplements useful? by Jane E Freedman. (JACC Journals)

#Tomato Chemical Compounds Inhibits #LiverCancer Compared to Those of #Doxorubicin and #Camptothecin, Researchers Suggest

Kyle J. Norton


Cancer is a class of diseases caused by cells growing disorderly and uncontrollably in our bodies.

Liver cancer is a chronic medical condition associated with irregular cell growth in the liver tissues.

The liver is the largest internal organ that only filters out blood from the intestine before passing it to other parts of the body, but also produces bile to aid digestion, build strong cell walls, and vitamin D and steroid hormones.

The liver joined with the kidney and skin is considered 3 detoxed organs in the human.

Most common liver cancers are* Hepatocellular carcinoma, which is the most common liver cancer accounting, accounting for 75 percent of all cases caused by the DNA alternation of hepatocytes, predominant liver cells.

Epidemiologically, primarily hepatocellular carcinoma has been found to metastasize to the pancreas, intestines, and stomach.

* Cholangiocarcinoma, also known as bile duct cancer, is caused by abnormal cell growth in the small, tube-like bile ducts in the liver, accounting for 10 to 20% of all liver cancer cases.

Out of many prevalent factors that cause the onset of liver cancer, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a strong impact on increasing the risk of liver cancer.

Dr. Qiu-Ye Lan, the lead scientist wrote, "Healthy dietary patterns may prevent many chronic diseases and is emphasized by 2015 US dietary guideline, but it remains unclear which dietary patterns may be a benefit to prevention of primary liver cancer (PLC)"

And, "Our findings suggest that the UPDP (an urban prudent dietary pattern (UPDP)) and TCDP (traditional Cantonese dietary pattern (TCDP) )were associated with lower, whereas the MPFP with the higher, risk of PLC".

Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods for the treatment of liver cancer, researchers examined the effect of tomato antiproliferative activities against human colon (HT29) and liver (HepG2) cancer cells.

Application of the tetrasaccharide tomato glycoalkaloid alpha-tomatine, the trisaccharide beta(1)-tomatine, the disaccharide gamma-tomatine, the monosaccharide delta-tomatine, and their common aglycon tomatidine showed better inhibition of liver cancer cell compared to the tested colon cell line.

Additionally, alpha-tomatine isolated from tomato at a concentration of 1 microg/mL demonstrated a greater effect against liver carcinoma cells compared to those of anticancer drugs doxorubicin and camptothecin

Furthermore, alpha-tomatine also inhibited normal human liver HeLa (Chang) cells without inducing any side effects.

Also in vitro, according to the tested assays,
* Alpha-tomatine isolated from green tomatoes induced liver cancer cell death compared to little inhibition of the cells by the three low-tomatine red tomato extracts.


* Alpha-tomatine from tomato also was highly effective in inhibiting all of the liver cell lines, compared to little cell inhibition of ehydrotomatine, tomatidenol, and tomatidine.

Collectively, the results not only showed the susceptibility to destruction varies with the nature of the alkaloid and plant extract but also how phytochemicals in plants worked synergistically in cancer inhibition.

Dr. Friedman M, the lead scientist said, "These findings extend related observations on the anticarcinogenic potential of glycoalkaloids and suggest that consumers may benefit by eating not only high-lycopene red tomatoes but also green tomatoes containing glycoalkaloids".


Taken together, tomato processed with a high amount of lycopene may be considered a dietary supplement for the prevention and treatment of liver cancer, pending to large sample size and multicenter human study.

Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best Before it's news, the Karate GB Daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tomatine-containing green tomato extracts inhibit the growth of human breast, colon, liver, and stomach cancer cells by Friedman M1, Levin CE, Lee SU, Kim HJ, Lee IS, Byun JO, Kozukue N. (PubMed)
(2) Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver(HepG2) cancer cells by Lee KR1, Kozukue N, Han JS, Park JH, Chang EY, Baek EJ, Chang JS, Friedman M. (PubMed)
(3) Dietary patterns and primary liver cancer in Chinese adults: a case-control study by Qiu-Ye Lan,1 Gong-Cheng Liao,1 Rui-Fen Zhou,1 Pei-Yan Chen,1 Xiao-Yan Wang,1Min-Shan Chen,2 Yu-Ming Chen,1 and Hui-Lian Zhu. (PubMed)

#Chinese Kidney Decoction Improves Symptoms of #Asthma and Prevent #Emphysema, Researchers Say

Kyle J. Norton

Respiratory disease is a medical condition that affects the breathing organs and tissues including Inflammatory lung disease, obstructive lung diseases, restrictive lung diseases, respiratory tract infections, trachea, bronchi, bronchioles, alveoli, nerves, and muscle breathing,...
The most common symptom of respiratory disease is shortness of breath.

The lungs formed part of the respiratory symptoms, are a pair of spongy, air-filled organs located on either side of the chest (thorax). The organ plays a critical role in inhaling oxygen to the body and exhaling carbon dioxide from the body.

Asthma is a medical and chronic condition characterized by the long-term inflammation of the airways of the lungs.

The most common symptoms of asthma are episodes of wheezing, coughing, chest tightness, shortness of breath, and reversible airflow obstruction and bronchospasm.

Asthma attack in most cases is triggered by exposure to various irritants and substances that trigger allergies (allergens). However, genetic preposition and family history are also found in patients with asthma.

Asthma not only interferes with daily activities and also can lead to a life-threatening asthma attack. Treatment of asthma is to reduce the frequent episodes and severity of the attacks.

According to the statistics provided by the Centers for Disease Control and Prevention (CDC), in the US, 1 in 13 people have asthma. In other words, over 26 million Americans have asthma and half of that is children.

Believe it or not, African Americans in the U.S. die from asthma at a higher rate than people of other races or ethnicities.

Dr. Laurent Guilleminault, in the environmental effect in the risk asthma, said, "The rates of asthma and allergy (Type 1 hypersensitivity disorders) have been increasing worldwide for the last few decades. Various theories have been proposed to account for this alarming trend. One of these is the impact of environmental toxicants".


And, "repletion of glutathione levels (with oral supplementation of N-acetylcysteine), and enhancement of glutathione transferase function (using sulforaphane) might be therapeutic options for countering type 1 hypersensitivity disorders caused by environmental chemicals".

In other words, environmental toxins cause reduced levels of antioxidants in the body and are associated with the risk of asthma onset

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used for thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches obstruction in the nasal passage, etc.

In finding a potential compound for the treatment of respiratory disease, researchers examined the effect of invigorating Kidney (Viscum coloratum 15g, Psoralea corylifolia 15g, Eucommia ulmoides 15g, Lycium chinense 9g, Tussilago farfara 15g, Artemisia capillaris 9g, and Pogostemon cablin 9g as daily dosage) on asthma by measuring maximal expiratory flow-volume curve (MEFV) in the convalescent stage.

In a total of 66 cases of asthmatics were examined, researchers found that before treatment by the invigorating Kidney decoction, the results of FEV, PEF, V75, V50, and V25 in 35 cases or 53.03% of the total demonstrated a significantly negative effect compared with healthy persons.

In other words, in the convalescent stage, convalescent stage, over half of the asthmatics showed obstruction of airways and chiefly of small airways.

According to the tested analysis, after-treatment of the decoction only exerted effects on different parameters associated with the improvement of MEFV to some extent but also reversed the airway obstruction of asthmatics in the convalescent stage.

Based on the findings, researchers said, "the authors indicated that the prompt treatment for asthmatics in the convalescent stage was conducive early to prevent emphysema and confirmed that the treatment with Chinese herbs of chiefly invigorating Kidney deserved to be propagated.".

Taken together, coltsfoot used alone and combined with other herbal medicines may be considered a remedy for the treatment of asthmatics in the convalescent stage, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's News, the Karate GB Daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Measurement of MEFV in 66 cases of asthma in the convalescent stage and after treatment with Chinese herbs].[Article in Chinese] by Fu JX. (PubMed)
(2) Do environmental toxicants contribute to allergy and asthma? by Crinnion WJ. (PubMed)

#Turmeric #Curcuminoid Fractions Process Anti Hypercholesterolemic Activity, Scientists Find

Kyle J. Norton

Cholesterol, a waxy substance produced by the liver or the dietary plays a critical role to aid digestive function in absorbing nutrients and fluids, building strong cell membranes, and producing steroid hormones and vitamin D. However, excessive amounts in the blood have been found to induce plaque built-up on the arterial wall, leading to hypercholesterolemia, a leading cause of heart disease, and stroke.
Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.

The condition is a result caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).


People with hypercholesterolemia at the early stage are asymptomatic. However, patients with familial hypercholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.

According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor of heart disease, a leading cause of death in the US.

In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol. and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.

Sadly, only 50% of people hypercholesterolemia are getting treatment.

Out of many risk factors associated with the risk of hypercholesterolemia, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a strong impact on the increased incidence of hypercholesterolemia in the US.

Dr. ROBERT B. KELLY, the lead scientist wrote, "The most beneficial changes result from reducing intake of saturated and trans fats; increasing intake of polyunsaturated and monounsaturated fats; fortifying foods with plant stanols or sterols; isocalorically adding tree nuts to the diet; consuming one or two alcoholic drinks per day; and adopting a Portfolio, Mediterranean, low-carbohydrate, or low-fat diet".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In finding a potential compound for the treatment of hyperlipidemia, researchers examined the efficacy of curcumin on hypercholesterolemia, one of the most important risk factors for atherosclerosis and subsequent cardiovascular diseases.

The experimental study included selected 24 male Sprague-Dawley rats that were divided into six groups, namely normal group diet, high-cholesterol diet (HCD) 2%, HCD + 100 mg/kg b.w. curcuminoid fraction, HCD + 300 mg/kg b.w. curcuminoid fraction, HCD + cider 1% v/v, and HCD + curcuminoid cider 2% v/v for 4 weeks.

According to the tested analysis of total cholesterol levels measured on days 1, 14, and 28, curcuminoid cider at 2% v/v significantly lowered total cholesterol levels compared to the positive control.

Furthermore, curcuminoid fractions at 100 and 300 mg/kg) and curcuminoid cider (1 and 2% v/v) inhibited the gene expression of CD44 associated with membrane cholesterol and intercellular adhesion molecule (ICAM)-1 involved in the measurement of lipid metabolic impairment.

Moreover, curcuminoid fractions at 100 and 300 mg/kg) and curcuminoid cider (1 and 2% v/v) also lower the levels of iNOS, which has been found to mediate HCD-induced liver fibrosis.


Additionally, the applications also inhibited LOX-1 associated with high circulating cholesterol levels.

In other words, curcuminoid fractions at 100 and 300 mg/kg) and curcuminoid cider (1 and 2% v/v) displayed their hypocholesterolemic effects via attenuating genes related to oxidative stress in vivo.

Taken altogether, turmeric-processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of hypercholesterolemia, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best Before it's news, the Karate GB Daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Roles of Spicy Foods and Their Bioactive Compounds in Management of Hypercholesterolemia by Zhao Y1, Chen ZY. (PubMed)
(2) Efficacy of Oral Curcuminoid Fraction from Curcuma xanthorrhiza and Curcuminoid Cider in High-cholesterol Fed Rats by Mauren FM1, Yanti2, Lay BW. (PubMed)
(3) Diet and Exercise in the Management of Hyperlipidemia by ROBERT B. KELLY, MD, MS. (The American Family Physician)

#HealthyFood #Onion Used Alone or Combined with #Garlic Processes Anti Hypertensive Activity, According to Studies

Kyle J. Norton

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure is a condition associated with abnormally high blood pressure in the arteries.
High blood pressure is also a condition of a cluster of metabolic syndrome involved in the risk of cardiovascular disease and diabetes.

If the blood pressure stays high over time, it not can damage the heart muscle but also the body in many ways.

According to the statistic from the CDC, 1 of 3 U.S. adults or about 75 million people is living with high blood pressure. Unfortunately, only about half (54%) of these people have their high blood pressure under control.

There is no single cause of high blood pressure,
* Most unpreventable risk factors are family history, age, gender, ethnicity, and chronic kidney disease.

* Most preventable high blood pressure risk factors are physical inactivity, overweight or obese, unhealthy diet, smoking, and excessive alcohol drinking.

However, most people with some of the risk factors have never developed hypertension

Some researchers suggested that the rise of obesity associated with the promotion of a high-fat diet over the past decades may be the major influence on the onset of high blood pressure.

Dr. Wilde DW, the lead scientist said, "Dietary fat contributes to the elevation of blood pressure and increases the risk of stroke and coronary artery disease".

And, "an elevation of plasma FAs may contribute to the development of hypertension via a process involving the elevation of Ca(2+) current density and alteration of channel kinetics in the vascular smooth muscle membrane".

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.


Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

In finding a potent ingredient for the prevention of hypertension, researchers evaluated the effect of aqueous extract of garlic, white onion, and purple onion on subjects with blood pressure.

Elevated levels of an angiotensin-converting enzyme associated with the high blood pressure were inhibited by the aqueous extract of garlic, purple onion, and white onion in a concentration-dependent manner (0-4 mg/ml).

Additional differentiation also suggested that purple onion (IC50 = 0.59 mg/ml) had higher inhibitory effect on angiotensin-converting enzyme comapred to those of white onion (IC50 = 0.66 mg/ml) and purple onion (IC50 = 0.96 mg/ml).


Furthermore, all aqueous extracts showed a significant activity to scavenge 2,2- diphenyl-1-picrylhydrazyl (DPPH*) free radical and reduce Fe3+ to Fe2+ in a dose-dependent manner.

Based on the findings, researchers concluded, "a possible mechanism by which garlic, white onion, and purple onion exert... antihypertensive properties could be through the inhibitory effect on ACE,.. coupled with their ability to prevent lipid peroxidation in the pancreas and heart, which justify their strong antioxidant properties".

Taken together, onion used alone or combined with garlic may be considered a remedy for the prevention and treatment of hypertension, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory Effect of Garlic, Purple Onion, and White Onion on Key Enzymes Linked with Type 2 Diabetes and Hypertension by Oboh G1, Ademiluyi AO1, Agunloye OM1, Ademosun AO1, Ogunsakin BG. (PubMed)
(2) High-fat diet elevates blood pressure and cerebrovascular muscle Ca(2+) current by Wilde DW1, Massey KD, Walker GK, Vollmer A, Grekin RJ. (PubMed)

#Antioxidant #Betanin Exerts a Cytotoxic Effect Against the DNA Alternated Cells that Causes #Cancers and #InflammatoryDiseases

Kyle J. Norton

Inflammatory bowel disease (IBD) is a class of chronic conditions associated with the inflammation of the gastrointestinal tract, including
* Ulcerative colitis is a chronic inflammation and ulcers found in the innermost lining of the colon and rectum.

* Crohn's disease. is a type of IBD that causes inflammation of the lining of the digestive tract, other than the colon and rectum.


The most common symptoms of IBD are severe diarrhea, abdominal pain, fatigue, and weight loss. Long-term persistent symptoms such as weight loss may be life-threatening.

If you have experienced some of the aforementioned symptoms, please make sure to check with your doctor to rule out the possibility.

The causes of IBD are unknown. However, some researchers suggested that the promotion of a high-fat diet over the past few decades that caused the alternation of the ratio of gut microbiota may be the major culprit in facilitating the onset of IBD.

The research of Case Western Reserve University, wrote, "A high-fat diet may lead to specific changes in gut bacteria that could fight harmful inflammation -- a major discovery for patients suffering from Crohn's disease, research indicates. Crohn's disease, a type of inflammatory bowel syndrome, causes debilitating intestinal swelling, cramping, and diarrhea".

Betanin is a phytochemical in the class of red and yellow indole-derived pigments of betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a treatment for inflammatory bowel disease (IBS), researchers examined the effect of beetroot (Beta vulgaris var. Rubra) products and their major component betanin on the reactive oxygen species (ROS) production and DNA damage in vitro.

In neutrophils isolated from the blood of patients with inflammatory bowel disease--ulcerative colitis (UC) and Crohn's disease (CD), injection of betanin at 100 μM for 24 h increased DNA damage, according to the comet assay.

However, in Caco-2 cells. injection of betanin at 100 μM for 24 h showed a lesser pronounced stimulation of DNA damage.

Treatment of Caco-2 cells with H2O2 caused a 4-fold increase of DNA strand breaks in comparison to untreated cells, but pre-treatment with betanin reduced DNA damage in these cells.

In other words, betanin exerted a cytotoxic effect against the DNA alternated cells but inhibited the free radical expression in the induction of DNA damage in normal cells.

More precisely, betanin led to the release of ROS and apoptotic cell death.

Based on the findings, researchers wrote, " betanin may exert anti-inflammatory and potentially cancer-preventive activity".

Taken altogether, betanin may be considered a supplement for the prevention and treatment of inflammatory bowel disease, pending the confirmation of a larger sample size and multicenter human study.

Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W. (PubMed)
(2) High fat diet reduces gut bacteria, and Crohn's disease symptoms by Case Western Reserve University. (Science Daily)

#Pintobeans Inhibit Markers and Gene Associated with the Levels of #Cholesterol, Researchers Find

Kyle J. Norton

Cholesterol is a waxy substance carried around by lipoproteins, that do not mix with water-based blood in our body.

Cholesterol is needed for our body to build cell walls make hormones and vitamin D, and create bile salts that help to digest fat, particularly in the building of strong cell membranes. However, too much of it can be dangerous because cholesterol cannot dissolve in your blood.

There are 2 types of cholesterol. The low-density lipoprotein is also known as bad cholesterol which performs the aforementioned activity in the right levels and the high-density lipoprotein which returns cholesterol back to the liver for reuse.

However, overexpression of cholesterol can cause plaque building up on the arterial wall, leading to arterial narrowing, wall stiffness, and hardening, some major causes of heart disease and stroke.

Although high blood cholesterol does not induce any symptoms, a prolonged period of uncontrolled high blood cholesterol can cause complications of chest pain, the early signs of coronary artery disease, heart attack,.... and stroke.

According to medical guidelines, the normal goal of non-HDL cholesterol levels should be 30 mg/dL higher than the LDL cholesterol level.

For example, if your non-HDL cholesterol level is LDL cholesterol 30 mg/dL = 130 mg/dL and your HDL is 40 mg/dL = Non-HDL-c/HDL-c ratio of 3.25, the ideal range of the ratio.

The healthy ratio of blood cholesterol is 4 (LDL)/1 (HDL). If you have a number that is lower than 4, you have healthy blood cholesterol.

Hyperlipidemia is one member of the cluster conditions of metabolic syndrome, therefore, if you have a number that is higher than 4, your risk of cardiovascular is increased compared to people with healthy levels.

On finding a natural ingredient for the prevention and treatment of diseases associated with high blood cholesterol, scientists examined the changes in cholesterol metabolism in response to whole pinto beans (wPB) and their hulls (hPB) supplemented into a diet rich in saturated fat in hamsters.

The pinto bean is also known as the common bean, genus Phaseolus, and the family Fabaceae. It has a mottled appearance of darker reddish-brown spots on a lighter brownish-beige background, thus appearing painted or spotted.

The study included forty-four 9-wk-old male Golden Syrian hamsters that were randomly assigned to 4 diet groups (n = 11), including a 5% (wt:wt) fat diet [normal-fat diet (NF)], a 15% (wt:wt) fat diet [diet rich in saturated fat (HSF), saturated fatty acids accounted for 70% of total fatty acids], or HSF supplemented with 5% (wt:wt) wPB or 0.5% (wt:wt) hPB for 4 wk.

According to the plasma, liver, intestinal, and fecal samples that were collected to evaluate multiple cholesterol markers and gene targets,
* The plasma non-high-density lipoprotein (non-HDL) concentration was significantly reduced in the wPB- and hPB-supplemented groups by 31.9 ± 3.5% and 53.6 ± 3.2%, respectively, compared to the HSF group (P < 0.01), to concentrations comparable with the NF group

* The wPB-supplemented hamsters had significantly lower liver cholesterol (45.1%, P < 0.001) and higher fecal cholesterol concentrations (94.8%, P = 0.001) than those of the HSF group.


* The expressions of hepatic 3-hydroxy-3-methylglutaryl CoA reductase (Hmgcr) and small intestinal acyl-coenzyme A: cholesterol acyltransferase 2 (Acat2) associated with the elevation of blood cholesterol were significantly decreased in animals administered wPB (by 89.1% and 63.8%, respectively) and hPB (by 72.9% and 47.7%, respectively) compared to the HSF-fed counterparts (P < 0.05).

Based on the results, researchers suggest, "Pinto beans remediated high cholesterol induced by HSF in male hamsters by decreasing hepatic cholesterol synthesis and intestinal cholesterol absorption, effects which were partially exerted by the hulls".

Taken altogether, Pinto beans may be considered s functional for the treatment of high blood cholesterol, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Pinto Beans (Phaseolus vulgaris L.) Lower Non-HDL Cholesterol in Hamsters Fed a Diet Rich in Saturated Fat and Act on Genes Involved in Cholesterol Homeostasis by Nguyen AT1,2, Althwab S3,4, Qiu H3, Zbasnik R1, Urrea C5, Carr TP3, Schlegel V. (PubMed)