Long-Term Intake of #RapeseedOil Is Associated with a Reduced Risk of #MetabolicSyndrome, Scientists Show

Kyle J. Norton

A dietary pattern is the measurement of the quantity, variety, or combination of different foods and beverages in a diet, as well as the frequency of the foods, are habitually consumed.

The most common dietary patterns are
* The traditional diet, Wikipedia wrote, "Traditional foods are foods and dishes that are passed through generations or which have been consumed many generations. Traditional foods and dishes are traditional in nature, and may have a historic precedent in a national dish, regional cuisine or local cuisine".

* The Western diet is a standard American diet (SAD) associated with high intakes of red meat, processed meat, pre-packaged and refined foods, fried foods, high-fat dairy products, and high salt, and sugar foods.

Metabolic syndrome is a cluster of conditions associated with the increased risk of cardiovascular disease and diabetes.

The health problems found in the group include too much fat around the waist, elevated blood pressure, high triglycerides, elevated blood sugar, and low HDL cholesterol.

In other words, if you have 3 of the conditions in the group, your risk of CVD and diabetes are increased substantially compared to those who have less.

According to the statistics, approximately 30% of people in the US are living with metabolic syndrome.

Believe it or not, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 1988–1994 to 2007–2012, increasing from 25.3% to 34.2%.

Rapeseed, also known as rape, or oilseed rape, is a member of the family Brassicaceae (mustard or cabbage family), cultivated in suitable climate regions for its oil-rich seed for commercial profits.

In finding a potential compound for the prevention of heart disease, researchers at the University of Applied Sciences investigated the effects of a hypo energetic diet with low energy density (ED) enriched in rapeseed oil derived n-3 fatty acid α-linolenic acid (ALA), in patients with metabolic syndrome.

The human trial included eighty-one patients with metabolic syndrome randomly assigned to receive either rapeseed oil derived with high MUFA content and an ALA intake of 3.5 g/d on body weight or olive oil diet rich in MUFA but with a low ALA content.

According to the results, after a 6-month dietary intervention, the rapeseed oil and olive oil groups showed a significant in reduced body weight and metabolic factors associated with cardiovascular risk.

In other words, intervention groups with rapeseed oil not only significantly decrease the systolic blood pressure, but also reduce total cholesterol and LDL-cholesterol, and insulin levels in patients with metabolic syndrome.


More interestingly, serum triglycerides (TAG) associated with cardiovascular and nonfatty liver disease risk factors were significantly reduced only in the high ALA intake, compared to no effect on the low ALA group.

Based on the findings, researchers said, "Our dietary food pattern with a low ED and high intakes of MUFA and ALA may be a practical approach for long-term dietary treatment in patients with the metabolic syndrome".

Taken altogether, rapeseed oil may be considered a supplement for the prevention and treatment of metabolic syndrome, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of a rapeseed oil-enriched hypo energetic diet with a high content of α-linolenic acid on body weight and cardiovascular risk profile in patients with the metabolic syndrome by Baxheinrich A1, Stratmann B, Lee-Barkey YH, Tschoepe D, Wahrburg U. (PubMed)

#Naringenin Found in #Tomatoes Inhibits Bacteria Associated with the Onset of #Pneumonia, Researchers Show

Kyle J. Norton


Pneumonia is a medical condition associated with the infection of the lung. In adults, the most common cause of pneumonia is bacterial infections such as Staphylococcus aureus.

Viruses or fungi also have been found to induce the onset of the disease.

The most common symptoms of pneumonia are persistent coughing with phlegm (mucus) fever, sweating, chills, and chest pain. However, depending on the types of pathogens that cause the infection.

In severe cases, pneumonia is life-threatening. Some patients at this stage also experience persistent shortness of breath due to severe inflammation in the air sacs of the lungs.

According to epidemiological studies, most cases of pneumonia are acquired from either hospitals or communities caused by people who have the disease.

Some researchers suggested people who have weakened such as elderly or immature immune systems such as babies and underage children are more prone to the disease.


Dr. Sanjay Sethi at the University at Buffalo SUNY wrote, "Pneumonia is an infection of the lungs. Pneumonia in people whose immune system is weakened or impaired (for example, by AIDS, cancer, organ transplantation, or the use of certain drugs) is often caused by different organisms than those that cause pneumonia in healthy people".

In other words, people who are treated with chemotherapy drugs due to cancer or immune suppressants, and diseases associated with immunity are susceptible to pneumonia developing.

Most cases of pneumonia are treated with antibiotics. Depending on the condition, treatment may include medicine for reduced coughing, pain, and fever with an aim to improve the patient's quality of life.

If you are taking certain types of antibiotics for the treatment of pneumonia, please make sure you know all the side effects for preventive measures.

Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On finding a potential ingredient for the treatment of Staphylococcus aureus pneumonia, researchers examined the effect of naringenin found abundantly in tomatoes.

In the Staphylococcus aureus pneumonia model, naringenin protected the lung cells' integrity and viability by inhibiting the production of α-toxin.

Where α-toxin is an essential virulence factor found in patients with Staphylococcus aureus pneumonia.

Furthermore, at 16 μg/ml of naringenin, treatment organisms showed reduced expression of α-toxin significantly compared to the untreated group.

Moreover, in vivo, a mouse model of S. aureus pneumonia treated with naringenin demonstrated a significant effect in attenuating symptoms of lung injury and inflammation against infection.


In other words, naringenin acted as a natural antibiotic in preventing the overexpression of α-toxin produced by Staphylococcus aureus through its antibacterial activity.


Based on the findings, Dr. Zhang Y, the lead scientist after taking into account co and confounders wrote in the final report, "These results suggest that naringenin is a promising agent for the treatment of S. aureus infection".

Taken together, tomatoes may be considered supplements for the prevention and treatment of Staphylococcus aureus pneumonia, pending the confirmation of the larger sample size and multicenter human study.

Intake of naringenin in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of α-toxin production by subinhibitory concentrations of naringenin controls Staphylococcus aureus pneumonia by Zhang Y1, Wang JF, Dong J, Wei JY, Wang YN, Dai XH, Wang X, Luo MJ, Tan W, Deng XM, Niu XD. (PubMed)
(2) Pneumonia in Immunocompromised People By Sanjay Sethi, MD, University at Buffalo SUNY. (MSD Manual)

#HealthyVeggie #Broccoli #ProteinHydrolysates Exerts hypotension Inhibitory Activity in Vitro, Researchers say

Kyle J. Norton

Blood pressure is the force of the blood pushing against the arterial walls. In high blood pressure, the heart has to work harder than normal to pump blood through the circulation system. Over time, high blood pressure has been found to cause damage to the heart and arteries.

Hypertension or high blood pressure is a condition characterized by persistent high blood pressure.

In the US approximately, one-third of adults have high blood pressure, affecting over 77 million people in the country.

Additionally, among adults aged 20 and older in the United States, in the non-Hispanic whites community, 33.4 percent of men and 30.7 percent of women are infected by the syndrome.

High blood pressure is a slowly developed condition. Unless the syndrome has caused damage to the blood vessel, otherwise symptoms cannot be detected.

High blood pressure is a chronic condition associated with an unhealthy lifestyle and chronic diseases such as kidney disease, leading to the onset of strokes and cardiovascular disease.

In other words, if you can control your diet, such as making changes to your lifestyle, maintaining an ideal weight, and dieting with low salt, you could do just fine without the drugs.

The cause of high blood pressure is a result of hardening and thickening of the arteries (atherosclerosis), due to the slow progression of plaques accumulated on the wall of the arteries.


According to the American Heart Association (AHA), patients with blood pressure that is higher than 130 over 80 millimeters of mercury (mmHg) are considered to have hypertension.

Untreated chronic high blood pressure may induce complications of heart attack, stroke, and other health conditions.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

In finding a potential plant that processes anti-high blood pressure, researchers examined the broccoli protein hydrolysates' inhibitory activity in vitro and hypotensive effect in vivo.

According to the results of the analysis,
* Three ACE inhibitory peptides were isolated and identified as IPPAYTK, LVLPGELAK, and TFQGPPHGIQVER, and their inhibitory IC50 values were 23.5, 184.0, and 3.4 μM, respectively.

* LVLPGE and LAK, two novel peptides exhibited the highest ACE inhibitory activity associated with lowering hypertension with IC50 values of 13.5 and 48.0 μM, respectively.

* Moreover, the hypotensive effect of the peptides was assessed after oral administration to spontaneous hypertensive rats (SHRs).

Collectively, researchers said, "LVLPGE and LAK demonstrated a significant hypotensive effect in vivo. Protein from broccoli may thus constitute a potential antihypertensive peptide source".

Taken together, broccoli may be considered a functional food for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In Vitro and in Vivo Studies on the Angiotensin-Converting Enzyme Inhibitory Activity Peptides Isolated from Broccoli Protein Hydrolysate by Dang Y1, Zhou T2, Hao L1, Cao J1, Sun Y1, Pan D. (PubMed)

#RedCabbage #Anthocyanin (RCA)-Enriched #Extract Protects the Cell's Integrity Against Oxidative Stress Through Its Antioxidant Activity

Kyle J. Norton

Oxidative stress is a condition caused by an imbalance of the ratio of free radicals and antioxidants in the body. In other words, oxidative stress is either caused by overexpression of free radicals or depletion of antioxidant enzymes in the body.

Some researchers suggested that oxidative stress may also arise due to the chain reaction of free radicals in which free radicals donate or intercept an electron from other stable molecules.

Long-term oxidative stress present in the body can cause protein and lipid damage and alternation of cell DNA, leading to the onset of chronic diseases, including cardiovascular disease, diabetes, and cancer.

More precisely, exogenous factors, such as cigarette smoke, and endogenous factors, such as the oxidative burst from activated macrophages are some of the factors involved in the risk of oxidative stress.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.

Due to their nature to become stable, free radicals readily donate or steal an electron from other molecules, leading to the chain of domino effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radicals before they can cause a chain reaction in facilitating protein, lipid, and cell damage.

Antioxidants can either be produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.


Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.

In findings of a natural whole for the prevention and treatment of diseases associated with oxidative stress, researchers investigated the effects of red cabbage anthocyanin (RCA)-enriched extract on H₂O₂ expression on HepG2 cells.

According to chemical analysis, all derivatives of cyanidin (268 ± 2 μg/mg) found in RCA, mainly with 19% nonacylated, 51% monoacylated, and 31% diacylated structures with ferulic, sinapic, p-coumaric, and caffeic acids exerted antioxidant activity against the oxidative stress induced by the injection of H₂O₂.

Furthermore, the application of RCA extracts markedly ameliorated cell apoptosis and improved viability.

Moreover, in another study, cabbage extract protected against H2O2-induced cell death and did not elicit any cytotoxic effects by suppressing ROS production and increasing the expression of antioxidant proteins (SOD-1, catalase, and GPx) produced by the host.


In oxidative stress-exposed H9c2 cells, the protective effects of cabbage extract also inhibited apoptotic responses and activation of MAPK proteins (ERK1/2, JNK, and p-38) involved in the resistance of apoptosis by preserving mitochondrial functions.

Based on the results, researchers wrote, "Cabbage extract protects against oxidative stress and suggests that it can be used as an alternative therapeutic strategy to prevent the oxidative stress in the heart".

Taken together, cabbage may be used as a functional food for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Characterization of Purified Red Cabbage Anthocyanins: Improvement in HPLC Separation and Protective Effect against H₂O₂-Induced Oxidative Stress in HepG2 Cells by Fang S1, Lin F2, Qu D3, Liang X4, Wang L. (PubMed)
(2) Cabbage (Brassica oleracea var. capitata) Protects against H2O2-Induced Oxidative Stress by Preventing Mitochondrial Dysfunction in H9c2 Cardiomyoblasts by Yang DK. (PubMed)

Phtochemical #Lutein/#Zeaxanthin Consumption were Markedly Associated with a Decreased Risk of #ColorectalCancer, Researchers Reveal

Kyloe J. Norton

Cancer is a class of diseases associated with irregular cell growth in the tissue of organs.

The colon-rectum formed as a part of the digestive system is involved in the absorption of water from the small bowel contents and the breaking down of certain materials in the feces into substances which of them to be reabsorbed and reused by the body.

Colorectal cancer is cancer located in the colon or rectum caused by the alternation of cell DNA. Most cases of colorectal cancer begin in the cells on the surface of inner ling tissue in either the colon or rectum, before multiplying to form a tumor.


Colorectal cancer is a relatively very common and slowly growing and progressing cancer.
The disease is also the third most commonly diagnosed cancer in developed countries, including the US and Canada.

According to the statistics provided by the American Cancer Society, in the US,
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in 2019.

Additionally, colorectal cancer will also cause the death of 51,020 Americans in 2019.

Overall, the lifetime risk of colorectal cancer developing is 1 in 22 (4.49%) in men and 1 in 24 (4.15%) in women.

Besides adenocarcinomas, the common type of colorectal cancer originated in epithelium tissues and squamous cells that make up the bowel lining together with the gland cells, other types of colorectal tumors include* Carcinoid
Carcinoid is an unusual type of slow-growth neuroendocrine tumor in the hormone-producing tissue in the digestive system. The condition may look benign but can spread to other parts of the body as they grow

* Leiomyosarcomas
Leiomyosarcomas are a rare and resistant type of colorectal cancer and are generally not very responsive to chemotherapy or radiation. They are a malignant abnormal mass of tissue of smooth muscles of the colon, comprising between 5–10% of soft tissue sarcomas.

* Lymphomas
Bowel lymphomas are rare and more likely to start in the rectum rather in the colon. Many patients with lymphomas are diagnosed in the late stage and already spread to other organs.

* Melanomas
Melanomas are rare malignant tumors of cells that produce dark pigment. This type of bowel cancer usually originates from somewhere else and then spread to the bowel.

Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.

On finding a potential compound for the treatment of colorectal cancer, researchers investigated whether dietary lutein/zeaxanthin, the major compounds found in carotenoid intake affect colorectal cancer risk in patients with a DICER1 rs3742330 polymorphism.

The experiment included 923 colorectal cancer patients and 1,846 controls based on eligibility criteria, that answered the semiquantitative food frequency questionnaire and the DICER1 rs3742330 genotype.

Based on the returned questionnaires differentiation, the highest quartile of lutein/zeaxanthin consumption was inversely associated with colorectal cancer risk.

In genotype analysis, patients who carry the G allele (AG + GG) showed a significantly reduced colorectal cancer incidence compared to AA carriers.
Furthermore, patients with the G allele (AG + GG) along with high lutein/zeaxanthin consumption were markedly associated with a decreased colorectal cancer risk, particularly in rectal cancer compared to AA carriers with low lutein/zeaxanthin intakes.

The results strongly suggested that carotenoids' major compounds lutein/zeaxanthin has a strong implication on the colorectal cancer risk in patients with the DICER1 rs3742330 genotype.

Dr. Kim J, the lead scientist after taking into account co and confounders wrote in the final report, "Colorectal cancer risk was related to an interactive effect between dietary lutein/zeaxanthin intake and the DICER1 rs3742330 polymorphism".

Taken altogether, carotenoids may be considered a remedy for the prevention and treatment of colorectal cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(2) Antiproliferative effects of carotenoids extracted from Chlorella ellipsoidea and Chlorella vulgaris on human colon cancer cells by Cha KH1, Koo SY, Lee DU. (PubMed)

Rectal cancer
(1) (1) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(2) Dietary Lutein Plus Zeaxanthin Intake and DICER1 rs3742330 A > G Polymorphism Relative to Colorectal Cancer Risk by Kim J1, Lee J1, Oh JH2, Chang HJ2, Sohn DK2, Kwon O3, Shin A4, Kim J. (PubMed)
(3) Bowel (Colorectal ) Cancer by Kyle J. Norton

#PolyherbalPpreparation From #Ashwagandha Exhibits Immunomodulatory Effects Against HIV Infection, Researchers Say

Kyle J. Norton

Human immunodeficiency virus -1 (HIV-1) is one of 2 types of HIV precipitated by acquired immunodeficiency syndrome (AIDS), transmitted through direct contact with HIV-infected body fluids, including blood, semen, and genital secretions,...

Human immunodeficiency virus HIV-1 is the most widespread type worldwide that can lead to acquired immunodeficiency syndrome (AIDS).

Acquired immunodeficiency syndrome (AIDS) is a chronic condition caused by the infection of the human immunodeficiency virus (HIV).

According to statistics, AIDS is the fifth leading cause of death in the US.

People between the ages of 25 and 44 in the United States are at substantially higher risk compared to other age groups.

Approximately 36.7 million people worldwide lived with HIV/AIDS in 2016, including, 2.1 million children less than 15 years of age.

According to epidemiological studies, people who serval sexual partners are the most at risk of HIV infection.

However, the virus can also transmit through infected blood transfusion, from infected mothers to children.

Most people infected by the HIV virus may experience symptoms of fever, muscle aches, and joint pain similar to those of influenza in the early stage of the viral attacks.

According to epidemiological studies, people who have serval sexual partners are the most at risk of HIV infection.

However, the virus can also transmit through infected blood transfusion, from infected mothers to children.

If untreated, the virus will slowly multiply and destroy the cells of the immune system, leading to chronic signs and symptoms of fever, fatigue, and swollen lymph nodes,...

If an infected individual has the numbers of T-cell count below 200, the person is considered to have AIDs.

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In the urgency to discover a natural ingredient for the prevention of infectious diseases, researchers examined the clinical efficacy and safety of a new polyherbal preparation, Immu-25, in HIV-infected patients.

The open-label pilot study. included 36 patients (10 female, 26 male) with a mean age of 35 +/-10 years, with confirmed HIV infection with a CD4 count <500 cells/microL, and received two capsules of the test drug twice daily for 18 months.

According to the results of the study, the polyherbal preparation produced good symptomatic improvement within 6 months with an increase in mean (95% CI) weight from 58 (53-64)kg to 63 (56-69)kg, 64 (58-72)kg and 68 (62-74)kg after 6, 12 and 18 months of treatment, respectively.

The application decreased the incidence and severity of symptoms such as diarrhea, fatigue, anorexia, cough, and fever in the participants.

Furthermore, there was a decrease in the mean (95% CI) viral load from 326 438 (428 600-186 420) copies/mL to 180 495 (258 300-124 000) copies/mL and 22 069 (42 100-16 000) copies/mL after 6 and 12 months of treatment, respectively.


Most importantly, the decrease in viral load was associated with an increase in mean (95% CI) CD4 count from a baseline of 243 (203-388) cells/microL to 336 (263-486) cells/microL after 6 months of therapy, and this continued to rise to 527 (285-767) cells/microL (p < 0.001) and 618 (362-1012) cells/microL (p < 0.001) after 12 and 18 months of treatment, respectively.


However, mild gastrointestinal adverse effects had been reported by some of the participants.


Based on the evidence, researchers said, "herbal drug may have a good immunomodulatory effect and has potential as a co-therapeutic agent in the management of HIV infection. Further studies are warranted to confirm its therapeutic potential".

Taken altogether, Ashwagandha may be considered a supplement for the prevention and treatment of HIV infection, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of the antiretroviral activity of a new polyherbal drug (Immu-25) in patients with HIV infection by Usha PR1, Naidu MU, Raju YS. (PubMed)

#Phytochemical #Alliin Inhibits #Cardiotoxicity through Its Antixodaint Activity, Scientists Show

Kyle J. Norton

Cardiotoxicity is a condition caused by toxins accumulated in the heart that leads to damage to the heart muscle.
Cardiotoxicity reduced the heart's pumping blood capability, leading to a decrease in oxygen-rich blood to nourish the body tissues and organs.

The most common symptoms of cardiotoxicity, are tiredness fatigue, chronic cough, water retention and shortness of breath.

If you have experienced some of the aforementioned symptoms that can be healed within a week or 2, please check with your doctor to rule out the possibility.

The most common causes of cardiotoxicity are associated with patients receiving chemotherapy and intake of certain medications. However, infection, excessive alcohol consumption, medical conditions such as diabetes and thyroid disease, high blood pressure, and thiamine and Vitamin B deficiency have also been found to induce cardiotoxicity.

Some researchers suggested that the promotion of a high-fat diet over the past few decades that facilitate widespread obesity may increase the cardiotoxicity risk of obese who are treated by chemotherapy.

Dr. Mitra MS, the lead scientist said, "Often, chemotherapy by doxorubicin (Adriamycin) is limited due to life-threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity".

And, "HFD-induced obese rats are highly sensitized to doxorubicin-induced cardiotoxicity".

In other words, non-obese patients who follow the recommended diet before taking chemotherapy are for the treatment of cancer are less sensitive to doxorubicin-induced cardiotoxicity compared to a high-fat diet obese.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a potential compound with cardioprotective activity, researchers examined the effect of S-allyl cysteine sulphoxide (SACS) in isoproterenol (ISO)-induced cardiotoxicity in male Wistar rats.

The study included myocardial infarction induced by subcutaneous injection of ISO (150 mg/kg) once a day for 2 days followed by SACS (40 and 80 mg/kg) as pretreatment orally daily for a period of 35 days using an intragastric tube.

SACS pretreatment showed significantly lowered levels of free radicals and increased antioxidant activities of mitochondrial superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), and glutathione (GSH).

Furthermore, SACS pretreatment not only decreased the levels of mitochondrial cholesterol, free fatty acids (FFAs), triglycerides (TGs), and calcium, associated with plaque accumulation and the activity of xanthine oxidase (XOD) involved the production of the free radicals in the heart, but also increased significantly the levels of mitochondrial phospholipids of the inner membrane of the heart against damage.

Moreover, pretreatment of SACS also protected the heart mitochondrial fraction by increasing the activities of isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), alpha-ketoglutarate dehydrogenase (alpha-KGDH), NADH-dehydrogenase, and cytochrome C-oxidase.

Interestingly, oral administration of SACS for a period of 35 days showed no cardio effect in normal control rats.

In other words, SACS modulated heart function against mitochondrial cardiotoxicity without affecting the heart function in healthy control.

Based on the findings researchers said, "The effect at a dose of SACS 80 mg/kg was more effective than the dose 40 mg/kg. The results of the study conclude that SACS protects the mitochondria of the ISO-induced myocardial-infarcted rats".

In order to know more information about SACS cardioprotective activity, researchers examined the preventive role of SACS on glycoproteins and hematology in experimentally induced myocardial infarction in rats for 2 days.

Injection of SACS restored the abnormally significant increase in the levels of serum iron, uric acid and blood glucose, Na(+) and Ca(2+) characterized by heart damage and elevated blood glucose.

Furthermore, the significant decrease in the levels of plasma iron binding capacity, serum total protein, albumin/globulin ratio, heart K(+), and heart glycogen induced by isoproterenol (ISO) associated with heart tissues damage were also inhibited by the treatment of SACS in myocardial infarcted rats.

Moreover, SACS also modulated the immune response in the production of pro-inflammatory cytokines induced by isoproterenol (ISO) toxicity.

Additional differentiation of the results suggested that oral pretreatment with SACS (40 and 80 mg kg(-1)) daily for a period of 35 days prevents cardiotoxicity by improving all the biochemical parameters studied in ISO-induced rats.

Taken altogether, alliin may be considered a supplement for the prevention and treatment of cardiotoxicity, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Preventive effect of S-allyl cysteine sulphoxide (Alliin) on mitochondrial dysfunction in normal and isoproterenol-induced cardiotoxicity in male Wistar rats: a histopathological study by Sangeetha T1, Darlin Quine S. (PubMed)

(2) Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol induced myocardial infarction in male Wistar rats by Sangeetha T1, Quine SD. (PubMed)

(3) High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity by Mitra MS1, Donthamsetty S, White B, Mehendale HM. (PubMed)