#Lycopene Processes Anti Acute #Cholestasis Activity by Inhibiting Parameters Associated with Oxidativestress in Vivo, Researchers Say

Kyle J. Norton

Cholestasis is a condition associated with an improper secretion of bile by the liver, leading to symptoms of yellowish skin and whites of the eyes, skin itches, urine is dark urine, and stools with light-colored and smell foul.

The most common cholestasis is caused by diseases or conditions associated with the liver, bile duct, and pancreas.

More precisely, liver diseases such as acute hepatitis, alcoholic liver disease, primary biliary cholangitis with inflammation and scarring of the bile ducts, and cirrhosis due to viral hepatitis B or C are the most common causes of cholestasis.

Epidemiologically, long-term use of conventional medicines such as amoxicillin/clavulanate, chlorpromazine, and azathioprine is also found to induce the aforementioned condition.

In pregnancy, cholestasis has been found to increase symptoms of itchiness and the risk of fetal distress, preterm birth, or stillbirth.

The exact causes of cholestasis in pregnancy are unknown. However, the most common risk factors associated with cholestasis pregnancy are personal or family history of cholestasis of pregnancy and a history of liver damage.

Conventionally, treatment is depending on the severity of the symptoms induced by the conditions, including, ursodeoxycholic acid, to relieve itching and increase bile flow, and menthol creams, to help soothe the itching.


Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In finding a potential compound for the prevention of disease associated with liver oxidative stress, researchers examined the effects of lycopene on the pathogenesis of cholestasis.

Wistar albino rats. selected to the study were randomized into 3 groups, including the sham group subjected to a sham operation, the BDL group subjected to bile duct ligation (BDL), and the BDL+L group subjected to BDL and treated with 10 mg/kg body weight of lycopene.

Based on the tested analysis, after 7 days of treatment, the administration of lycopene showed a significant amelioration of the liver's abnormal function parameters in BDL rats.

The efficacy of lycopene in treating the acute cholestasis involved in the reduction or stoppage of bile flow by the liver was attributed to a significant reduce the levels of malondialdehyde, the liver oxidative stress markers, and nitric oxide associated with the overexpression free radicals.

Furthermore, lycopene also enhanced the levels of antioxidants produced by the host observed by the normalization of the levels of glutathione levels and catalase, superoxide dismutase, and glutathione S transferase activities in the BDL rats.

According to the comet assay, lycopene also protected cellular integrity against the alternation of DNA in the lymphocytes and hepatocytes of the BDL rats.

Based on the findings, researchers wrote, "These results suggest that lycopene might have protective effects on acute cholestasis".

Taken together, lycopene found in tomatoes may be considered supplements for the prevention and treatment of acute cholestasis, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hepatoprotective and antioxidant effects of lycopene in acute cholestasis by Tokaç M, Aydin S, Taner G, Özkardeş AB, Yavuz Taşlipinar M, Doğan M, Dündar HZ, Kiliç M, Başaran AA, Başaran AN. (PubMed)

#Ginger #Essentialoils Process a Strong Anti-Filament Formation and Growth of C. Albicans, Researchers Find

Kyle J. Norton


Ginger may be considered a natural antibiotics alternative for the treatment of Candida albicans overgrowth without inducing any side effects, some scientists suggested.

Candida albicans is an opportunistic pathogenic yeast formed part of the commensal gastrointestinal mycobiota.

Candida albicans overgrowth is the most prevalent cause of fungal infections in humans.

Epidemiological studies strongly suggested that long-term users of antibiotics that cause an imbalance of the gut microbiome, weakened immune system, unhealthy diet, and women who are pregnant and hormone imbalance of hormone near menstruation are susceptible to the onset of the condition.

If you experience symptoms of oral thrush, recurring genital or urinary tract infections, persistent digestive issues, or joint pain. particularly, in the skin and nail fungal infections, you may have a yeast infection.

Please check with your doctor to rule out the Candida albicans overgrowth possibility.

Dr. Carol A. Kumamoto in the research team of infectious diseases in the study "Inflammation and gastrointestinal Candida colonization" suggested that Candida albicans overgrowth can be caused by other medical conditions, associated with a digestive disorder.

In the study, the doctor wrote, "Recent studies, however, show that high-level Candida colonization is associated with several diseases of the gastrointestinal tract. Further, results from animal models argue that Candida colonization delays the healing of inflammatory lesions and that inflammation promotes colonization".

And, "Both inflammatory bowel disease and gastrointestinal Candida colonization are associated with elevated levels of the pro-inflammatory cytokine IL-17. Therefore, effects on IL-17 levels may underlie the ability of Candida colonization to enhance inflammation".

These results strongly suggested inflammation flames the overgrowth of Candida colonization in return, the overgrowth of Candida albicans induces persistently low-grade inflammation.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.


With an aim to find the natural ingredient or whole food for the replacement of conventional antibiotics without inducing any effects, researchers at the Teikyo University Institute of Medical Mycology investigated the effect of ginger against infection caused by Candida albicans.

4 preparations of the essential oils of young and mature rhizomes, air-dried and steamed rhizomes, and seed rhizomes of Zingiber officinale Roscoe (ginger) were compared in the study.

* All ginger essential oils processed a significant anti-Candida Albicans activity.

* Essential oil from the seed and air-dried rhizomes, exerted the highest effect compared to other preparations.

* The seed and air-dried rhizomes essential oils also had a potent inhibitory activity compared to ginger oleoresins obtained by ethanol and hypercritical carbon dioxide extraction and essential oils of 5 other plants in the family Zingiberaceae.
According to the chemical constituents assay, [6]-shogaol was most active against filament formation and growth of C. Albicans, followed by citral and [6]-gingerol.

Furthermore, ginger oleoresin, especially that obtained by ethanol extraction, with a high [6]-gingerol content exhibited potent anti-growth of C. Albicans compared to essential oils of ginger and other Zingiberaceae plants.

Moreover, a in vitro joint study by the Institute of Science and Technology, researchers launched an investigation to evaluate the antimicrobial activity of 2% chlorhexidine gel (CHX) isolated from ginger as an auxiliary chemical substance and intracanal medications on Candida albicans.

The study included 48 single-rooted human teeth randomly divided into four groups (n = 12), according to intracanal medications used: (1) Calcium hydroxide + apyrogenic saline solution (Ca(OH)2 + SS), (2) 20% ginger glycolic extract (GEN), (3) calcium hydroxide + 20% ginger glycolic extract (Ca(OH)2 + GEN), (4) apyrogenic SS (control).

At the end of the experiment, researchers found that
* CHX was effective in the complete elimination of E. coli and C. Albicans.

* ChX also significantly reduced and then completely eliminated E. faecalis after intracanal medication.

* All other applications also revealed a reduction of endotoxins, the outer membrane of the cell wall of Gram-negative bacteria.

In the final report, the research team concluded, "CHX and intracanal medication used were able to eliminate the microorganisms from the root canal; the endotoxins were reduced, yet not completely eliminated".


These results strongly suggested that ginger bioactive compound processes a significant antibacterial activity, particularly in those of C. Albicans.


Taken together, there is no doubt that ginger may be considered a functional food for the prevention and combined with primary medicine for the treatment of yeast infection with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Anti-Candida and radical scavenging activities of essential oils and oleoresins of Zingiber officinale Roscoe and essential oils of other plants belonging to the family Zingiberaceae by Takahashi M1, Inouye S, Abe S.(PubMed)
(2) Action of Chlorhexidine, Zingiber officinale, and Calcium Hydroxide on Candidaalbicans, Enterococcus faecalis, Escherichia coli, and Endotoxin in the Root Canals by Valera MC1, Oliveira SA2, Maekawa LE2, Cardoso FG3, Chung A2, Silva SF2, Carvalho CA2. (PubMed)
(3) Inflammation and gastrointestinal Candida colonization by Carol A. Kumamoto. (PMC)

#Healthy #Tomato/Lycopene Exerts a Strong Cytotoxicity Against Cancer Cells, Researchers Say

Kyle J. Norton


Cancers are a class of diseases caused by irregular cell growth in the tissue or organ in the body.

According to the Canadian Cancer Society, in 2017, over 200,000 new cases of cancer were diagnosed and 80,800 patients died from the disease in the same year.

Lung, colorectal, breast, and prostate cancer accounted for about half of all cancer diagnoses and deaths.
Believe it or not, 1 in 2 Canadian adults will develop cancer in their lifetimes and 1 in 4 will die of the disease.

At the early stage, patients with cancer may not experience any symptoms due to the very small size of the tumor and the cancer is still on the surface in the inner lining tissues. However, at the late stage after colonizing the complete organ, cancer cells not can travel a distance away from the originated site to affect other healthy tissue and organ, they can also cause some related and specific symptoms accompanied by general symptoms associated with other types of cancer.

Cancer is classified by the followings* Size of the cancer

* Invasive or not

* Whether cancer has spread to the lymph nodes

* Whether cancer has spread to distant parts or organs of the body.

There are 4 stages of breast cancer in TNM rating (where T is referred for tumor size, N is referred for Lymph Node status, and M is referred for invasive or not)

Where
# T: Tumor Size is divided into four classes: T-1 is between 0 - 2 cms, T-2 is between 2 - 5 cms, T-3 is > 5cms, and T-4 is a tumor of any size growing into the chest wall or skin, including inflammatory breast cancer.
#N: No swollen nodes: N-0, some swelling but negative node (not cancerous): N-1a, swelling nodes and positive node (cancerous): N-1b, quite swollen and bunched together: N-2, quite swollen and near the collarbone: N-3.
# M: if no cancer cell is found: M-0, cancer cells found: M-1.

The stages of cancer are
* Stage 1T-1 tumor and clear lymph nodes with no evidence of spreading (M-0), or T-1N-0M-0.
* Stage 2
Stage 2 is the combination of a combination of T-1, T-2, or T-3 tumor, N-0. N-1a and N-1b but no spreading (M-0)
* Stage 3
Stage 3 is the combination of all T or N but no spreading (M-0)
* Stage 4
Stage 4 is the combination of T, N-1a, N-1b, N-2, N-3, and M-1


Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to find a potential ingredient for the treatment of cancer with little or no side effect, researchers examined the effect of a novel strategy of formulating the lycopene-loaded whey protein isolate nanoparticles (LYC-WPI-NPs) ability for adenosine deaminase inhibition of the regression of the tumor with the percent lycopene entrapment in the range to 50 and 65%.

In the chemical release analysis, LYC-WPI-NPs enhanced the oral bioavailability of lycopene by controlling its release through the absorption in the lymphatic pathways.

According to the MTT-based colorimetric assay, LYC-WPI-NPs exerted significant cytotoxicity against MCF-7 breast cancer cells in vitro.

In an animal model-induced breast cancer, LYC-WPI-NPsd also demonstrated its prophylactic anticancer efficacy without causing the death of normal cells.

Based on the findings, researchers wrote in the final paper, "Conclusively, it may quite reasonable that lycopene loaded protein nanoparticles are competent to improve the biopharmaceutical attributes of lycopene and demonstrated prophylactic anticancer activity, decrease tumor proliferation and increase the survival rate of treated animals".


In other words, LYC-WPI-NPs significantly enhanced the lycopene anti-cancer biopharmaceutic activity compared to oral administration as seen in an animal model.

Taken altogether, tomatoes may be considered supplements for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tomato (Solanum lycopersicum) Carotenoids and Lycopene Chemistry; Metabolism, Absorption, Nutrition, and Allied Health Claims--A Comprehensive Review by Perveen R1, Suleria HA, Anjum FM, Butt MS, Pasha I, Ahmad S. (PubMed)
(2) Lycopene loaded whey protein isolate nanoparticles: An innovative endeavor for enhanced bioavailability of lycopene and anti-cancer activity by Jain A1, Sharma G2, Ghoshal G3, Kesharwani P4, Singh B5, Shivhare US4, Katare OP. (PubMed)

Beetroot Juices BRJ Inhibits Oxidative Stress and Inflammation Associated with Cardiac Tissue Damage, Scientists Suggest

Kyle J. Norton

Inflammation is a natural response of the immune system that tries to protect the body against invasive pathogens.
In the acute phase of infection, after receiving the information transmitted by the central nervous system, the white blood cells of the first line of defense stimulate the production of blood platelets to cover the site of damage and pro-inflammatory cytokines, killing off the foreign invaders.

During the acute phase of infection, overproduction of proinflammatory cytokines may cause damage to nearby healthy cells, leading to the formation of scars.

Most cases of infection are stopped at the acute phase of infection. The wound is slowly healed within a few days or weeks.

However, if the immune system can not destroy all pathogens within a period in the range of 3 to 8 weeks, it will adapt to the new change, leading to chronic inflammation.

In other words, chronic inflammation happens when the immune response lingers, causing low-grade inflammation. Chronic inflammation over time may damage the body tissues and organs.

In some cases, the infection may be latent in which the pathogen remains within the body for a long time without producing any symptoms, such as the hepatitis virus.

Diseases associated with chronic inflammation include cancer, heart disease, rheumatoid arthritis, type 2 diabetes, and obesity.

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

On finding a natural pigment for the prevention and treatment of disease associated with chronic inflammation, researchers examined the effects of Beetroot (Beta vulgaris L.) juice (BRJ, betacyanins, and betaxanthin) anti-inflammatory activity in vitro and in vivo.

The study included rats-induced myocardial injury by isoproterenol (ISP) at 24 h intervals, followed by oral administration of BRJ for 28 days at doses of 150 and 300 mg/kg.


According to the tested assays, pretreatment with BRJ (150 and 300 mg/kg) not only reduced oxidative/nitrosative stress but also restored the cardiac endogenous antioxidants in myocardial injury rats.

ISP-induced cardiac inflammatory cytokines such as NF-α, IL-6, and IL-10 and biomarkers of inflammatory promotion such as NF-κB also inhibited by the pretreatment of BRJ.

Oxidative stress-induced hyperlipidemia level was significantly reduced by the BRJ pretreatment.

The results strongly suggested that BRJ pretreatment mitigates cardiac dysfunction and structural damage by decreasing oxidative stress, and inflammation in cardiac tissues.

Dr. Raish M, the lead scientist said, "These results further support the use of BRJ in traditional medicine against cardiovascular diseases".

Furthermore, in rat-induced renal damage by Paraquat injected intraperitoneally randomly divided into four groups: a control group, a paraquat group, and two paraquat groups that were treated with betanin at 25 and 100 mg/kg/d three days before and two days after paraquat administration.

According to the differentiation of the proteins associated with pro-inflammatory cytokines and pathways that promote inflammatory stimulation, betanin administration found in the family of betacyanins alleviated the paraquat-incurred acute kidney injury by decreasing oxidative stress associated with the inflammatory expression.


Taken altogether, betacyanins processed abundantly bioactive ingredient betanin in BRJ may be considered a remedy for the prevention and treatment of disease associated with inflammation, pending the confirmation of a larger sample size and multicenter human study.

Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Beetroot juice alleviates isoproterenol-induced myocardial damage by reducing oxidative stress, inflammation, and apoptosis in rats by Raish M1, Ahmad A2, Ansari MA3, Alkharfy KM2, Ahad A1, Khan A3, Ali N4, Ganaie MA5, Hamidaddin MAA. (PubMed)
(2) Betanin attenuates oxidative stress and inflammatory reaction in kidneys of paraquat-treated rats by Tan D1, Wang Y2, Bai B1, Yang X2, Han J. (PubMed)

3,3'-#Diindolylmethane Inhibits Proteins Associated with the Production of Pro-Inflammatory Cytokines, Researchers Show

Kyle J. Norton


Inflammation is a natural response of the immune system which tries to protect our body by destroying harmful pathogens before they cause damage.

In the acute phase of infection, the immune system white blood cells in the first line of defense stimulate the production of a blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.

Overproduction of proinflammatory cytokines in some cases has been found to damage nearby healthy cells and tissues, causing the formation of scars.

In severe cases, a protein with duo functions in the production of pro and anti-inflammatory cytokines which produce anti-inflammatory cytokines under normal conditions also switch to produce pro-inflammatory cytokines.

Most harmful pathogens are stopped at the acute phase of infection. However, if the immune first line of defense can not completely destroy the invaders within a period of 3 to 8 weeks, it will compromise, leading to low-grade chronic inflammation.

Diseases associated with low-grade chronic inflammation include diabetes, cardiovascular disease, and cancer.

Conventional treatment of acute phase inflammation is to manage inflammation and prevent the risk of long-term damage, including anti-inflammatory nonsteroidal anti-inflammatory drugs (NSAIDs) which can be bought without a prescription.


3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.

In the urgency of finding a potential compound that processes a strong anti-inflammatory activity, researchers examined the effects of 3,3'-Diindolylmethane (DIM), a condensation product of indole-3-carbinol, and a glucosinolate naturally occurring in Brassica genus vegetables.

The study was carried out by differentiating the 3T3-L1 adipocytes in the co-cultured with RAW 264.7 macrophages and exposed to 20 µM, 40 µM, and 60 µM DIM for 24 h followed by 100 nM insulin for 20 min.

According to the tested assays, DIM significantly (p<0.05) reduced the production and mRNA expression of proinflammatory cytokines (MCP-1, IL-6, and TNFα) in a concentration-dependent manner.

Injection of DIM was found to increase the expression of proteins involved in the positive regulation of metabolism and proliferation (IRS-1 pY612 and Akt-1/PKB pT308) through its anti-inflammatory properties.

In other words, DIM influences the glucose metabolic pathway by exerting an anti-inflammatory effect.

Dr.Lopez-Vazquez A, the lead scientist said, "The potential therapeutic benefits of DIM in the treatment of glucose metabolic disorders deserve further studies".

In order to reveal more information about DIM anti-inflammatory effects, researchers examined the dietary components found in cruciferous vegetables, on brain inflammation.


Administration of DIM suppressed lipopolysaccharide (LPS)-induced expression of reactive oxygen species and promoted the production of antioxidant enzymes in the host by inhibiting the microglial hyperactivation by attenuating inflammatory transcription factor NF-κB.

Furthermore, DIM protected primary cortical neurons from inflammatory toxicity induced by LPS.

In vivo model of neuroinflammation, DIM also suppressed LPS-induced brain inflammation in the mouse hippocampus.

Based on the findings, Dr. Kim HW, the lead researcher said, "DIM may have beneficial potential against brain inflammation and neurodegenerative diseases through the negative regulation of the NF-κB signal pathway in microglia".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of diseases associated with chronic inflammation, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages by Lopez-Vazquez A1, Garcia-Banuelos JJ2, Gonzalez-Garibay AS1, Urzua-Lozano PE1, Del Toro-Arreola S1, Bueno-Topete MR1, Sanchez-Enriquez S3, Munoz-Valle JF4, Jave-Suarez LF5, Armendariz-Borunda J6, Bastidas-Ramirez BE. (PubMed)
(2) 3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation by Kim HW1, Kim J, Kim J, Lee S, Choi BR, Han JS, Lee KW, Lee HJ. (PubMed)

#Phytochemicals #Lycopene Inhibits NOX5 Overexpression that Cause Cancers, Researchers Find

Kyle J. Norton

NADPH oxidases, a multisubunit enzyme comprising membrane and cytosolic components plays a critical role to protect our body against pathogenic microorganism by maintaining immune function, cell growth, and apoptosis.
NOX family of NADPH oxidases deficiency can cause immunosuppression, leading to the overexpression of intracellular ROS that results in various lethal diseases.

Epidemiologically, diseases associated with the NOX family of NADPH oxidases deficiency-induced immunosuppression are frequent and recurrent pneumonia, bronchitis, sinus infections, ear infections, meningitis or skin infections, inflammation, and infection of internal organs, blood disorders, such as low platelet counts or anemia, digestive problems, such as cramping, loss of appetite, nausea and diarrhea and delayed growth and development, particularly in cancer developing.

The NOX family of NADPH oxidases overexpression caused by a defect of its different subunits produced high levels of ROS in the gastrointestinal tract that causes chronic inflammatory stress; cytokine induction, leading to the formation of digestive cancer such as colorectal cancer.

A recent joint study led by the National Cancer Institute suggested that lycopene may be used for the treatment of cancer that targets the expression of NADPH oxidase 4-5 (NOX4-5).

Cancer is a class of diseases caused by cell growth irregularly and uncontrollably due to the alternation of cell DNA. Over time, cancer cells induced tumor formation to become progressively worse, leading to secondary metastasis.

Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas.

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In patients with chronic pancreatitis, overexpression of free radicals has been found to orchestrate pancreatic cancer.

Furthermore, NOX5 overexpression increased the pre-malignant fibrotic states that lead to carcinomas of the lung and liver.

High expression of NOX5 is also found in patients with malignant melanomas, prostate cancer, and Barrett's esophagus-associated adenocarcinomas,

NOX4 and 5 are members of the NOX family of NADPH oxidases.

Furthermore, lycopene administration in vitro and Vivo significantly inhibited NOX4 protein expression at 2.5 μM, compared to other concentrations.

The efficacy of lycopene ameliorated the expression of NOX4 protein was attributed to the significant inhibition of the NOX4 mRNA expression associated with the function of NOX in the production of reactive oxygen species.

Dr. Roy K, the lead scientist in the investigation of the risk of cancer in the NOX family of NADPH oxidases wrote, "Over-expression of functional NOX proteins in many tissues helps to explain tissue injury and DNA damage from ROS that accompany pre-malignant conditions, as well as elucidating the potential mechanisms of NOX-related damage that contribute to both the initiation and the progression of a wide range of solid and hematopoietic malignancies".

In SK-Hep-1 cells, intracellular ROS levels were also decreased by the injection of lycopene.

Moreover, the levels of NOX4 protein expression, and NOX activity and the intracellular ROS associated with transforming growth factor β (TGF-β)-induced cancer cell metastasis also were eradicated by the activity of lycopene upon injection.

Other mechanisms such as proteins involved in anti-apoptosis and enhanced cancer cell migration, invasion, and adhesion were also inhibited by the expression of lycopene.

Taken altogether, lycopene may be considered a natural remedy for the prevention of cancer cell metastasis associated with the overexpression of NADPH oxidase, pending to the confirmation of larger sample size and multicenter studies.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene Inhibits Metastasis of Human Liver Adenocarcinoma SK-Hep-1 Cells by Downregulation of NADPH Oxidase 4 Protein Expression by Jhou BY1, Song TY2, Lee I3, Hu ML1,4, Yang NC. (PubMed)
(2) NADPH oxidases and cancer by Roy K1, Wu Y2, Meitzler JL2, Juhasz A2, Liu H1, Jiang G2, Lu J2, Antony S2, Doroshow JH. (PubMed)

#Peptide Fractions Isolated from Dehydrated Potatoes (Solanum) Inhibit ROS Inflammatory Damage Through Its Antioxidant Property

Kyle J. Norton

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radicals before they can cause a chain reaction in facilitating oxidative stress that causes damage to proteins, lipids, and cell DNA.

Oxidative stress is a result of an imbalance in the ratio of free radicals and antioxidants in the body.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.

Due to their nature to become stable, free radicals readily donate or steal an electron from other molecules, leading to the chain of domino effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.
Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.

Antioxidants can either be produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

However, in people with a weakened immune system, intake of dietary sources of antioxidants may be necessary.

There are 3 main types of antioxidants found in nature, including antioxidant enzymes produced by the host, including superoxide dismutase (SOD), glutathione peroxidase, glutathione reductase, and catalases, antioxidants vitamins, that may be injected from dietary sources such as fruits and vegetables, including vitamins A, C, D, and E and antioxidant-phytochemicals found in the plant including second metabolites.

Potato is the genus Solanum and belongs to the family Solanaceae. It is a good source of protein and according to the statistic, the annual diet of an average global citizen is about 33 kg (72.6 Lbs) of potato. The root veggie now is growing worldwide in a suitable climate for commercial profits and health benefits, thus its consumption is extremely variable and rapidly changing.

In finding a potential plant for the prevention and treatment of diseases associated with oxidative stress, researchers examined the potential of peptide fractions isolated from dehydrated potatoes on intestinal epithelial cells (IEC-6) under oxidative and inflammatory conditions.

Based on the results of differentiation,* Peptide fractions demonstrated a significantly inhibit the pro-inflammatory protein expression such as tumor necrosis factor-α and cycloxygenase-2 and inducible nitric oxide synthase.

* More importantly, the tested peptides also showed significant antioxidant activity by reducing reactive oxygen species (ROS) release induced by mitochondria, and nitrotyrosine formation

* Furthermore, the applications also increase the antioxidant response by heme oxygenase-1 and superoxide dismutase expression.

Additionally, the peptide fractions were able to significantly increase wound repair in IEC-6 induced by oxidative-inflammatory damage.

Collectively, researchers said, "The obtained results indicate the anti-inflammatory and antioxidant potential of dehydrated potatoes at the intestinal level".


Taken altogether, potatoes may be considered a functional food for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Inflammatory and Antioxidant Properties of Dehydrated Potato-Derived Bioactive Compounds in Intestinal Cells by Basilicata MG1,2, Pepe G1, Rapa SF1, Merciai F1,2, Ostacolo C3, Manfra M4, Di Sarno V1, Autore G1, De Vita D5, Marzocco S1, Campiglia P. (PubMed)