Kyle J. Norton
Oxidative stress is a condition caused by an imbalance of the ratio of free radicals and antioxidants in the body. In other words, oxidative stress is either caused by overexpression of free radicals or depletion of antioxidant enzymes in the body.
Some researchers suggested that oxidative stress may also arise due to the chain reaction of free radicals in which free radicals donate or intercept an electron from other stable molecules.
Long-term oxidative stress present in the body can cause protein and lipid damage and alternation of cell DNA, leading to the onset of chronic diseases, including cardiovascular disease, diabetes, and cancer.
More precisely, exogenous factors, such as cigarette smoke, and endogenous factors, such as the oxidative burst from activated macrophages are some of the factors involved in the risk of oxidative stress.
Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to their nature to become stable, free radicals readily donate or steal an electron from other molecules, leading to the chain of domino effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.
This chain of reaction is the cause of oxidative stress, a condition associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.
Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.
In other words, antioxidants inhibited the onset of free radicals before they can cause a chain reaction in facilitating protein, lipid, and cell damage.
Antioxidants can either be produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.
Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.
In findings of a natural whole for the prevention and treatment of diseases associated with oxidative stress, researchers investigated the effects of red cabbage anthocyanin (RCA)-enriched extract on H₂O₂ expression on HepG2 cells.
According to chemical analysis, all derivatives of cyanidin (268 ± 2 μg/mg) found in RCA, mainly with 19% nonacylated, 51% monoacylated, and 31% diacylated structures with ferulic, sinapic, p-coumaric, and caffeic acids exerted antioxidant activity against the oxidative stress induced by the injection of H₂O₂.
Furthermore, the application of RCA extracts markedly ameliorated cell apoptosis and improved viability.
Moreover, in another study, cabbage extract protected against H2O2-induced cell death and did not elicit any cytotoxic effects by suppressing ROS production and increasing the expression of antioxidant proteins (SOD-1, catalase, and GPx) produced by the host.
In oxidative stress-exposed H9c2 cells, the protective effects of cabbage extract also inhibited apoptotic responses and activation of MAPK proteins (ERK1/2, JNK, and p-38) involved in the resistance of apoptosis by preserving mitochondrial functions.
Based on the results, researchers wrote, "Cabbage extract protects against oxidative stress and suggests that it can be used as an alternative therapeutic strategy to prevent the oxidative stress in the heart".
Taken together, cabbage may be used as a functional food for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Characterization of Purified Red Cabbage Anthocyanins: Improvement in HPLC Separation and Protective Effect against H₂O₂-Induced Oxidative Stress in HepG2 Cells by Fang S1, Lin F2, Qu D3, Liang X4, Wang L. (PubMed)
(2) Cabbage (Brassica oleracea var. capitata) Protects against H2O2-Induced Oxidative Stress by Preventing Mitochondrial Dysfunction in H9c2 Cardiomyoblasts by Yang DK. (PubMed)
Tuesday, 22 August 2023
Phtochemical #Lutein/#Zeaxanthin Consumption were Markedly Associated with a Decreased Risk of #ColorectalCancer, Researchers Reveal
Kyloe J. Norton
Cancer is a class of diseases associated with irregular cell growth in the tissue of organs.
The colon-rectum formed as a part of the digestive system is involved in the absorption of water from the small bowel contents and the breaking down of certain materials in the feces into substances which of them to be reabsorbed and reused by the body.
Colorectal cancer is cancer located in the colon or rectum caused by the alternation of cell DNA. Most cases of colorectal cancer begin in the cells on the surface of inner ling tissue in either the colon or rectum, before multiplying to form a tumor.
Colorectal cancer is a relatively very common and slowly growing and progressing cancer.
The disease is also the third most commonly diagnosed cancer in developed countries, including the US and Canada.
According to the statistics provided by the American Cancer Society, in the US,
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in 2019.
Additionally, colorectal cancer will also cause the death of 51,020 Americans in 2019.
Overall, the lifetime risk of colorectal cancer developing is 1 in 22 (4.49%) in men and 1 in 24 (4.15%) in women.
Besides adenocarcinomas, the common type of colorectal cancer originated in epithelium tissues and squamous cells that make up the bowel lining together with the gland cells, other types of colorectal tumors include* Carcinoid
Carcinoid is an unusual type of slow-growth neuroendocrine tumor in the hormone-producing tissue in the digestive system. The condition may look benign but can spread to other parts of the body as they grow
* Leiomyosarcomas
Leiomyosarcomas are a rare and resistant type of colorectal cancer and are generally not very responsive to chemotherapy or radiation. They are a malignant abnormal mass of tissue of smooth muscles of the colon, comprising between 5–10% of soft tissue sarcomas.
* Lymphomas
Bowel lymphomas are rare and more likely to start in the rectum rather in the colon. Many patients with lymphomas are diagnosed in the late stage and already spread to other organs.
* Melanomas
Melanomas are rare malignant tumors of cells that produce dark pigment. This type of bowel cancer usually originates from somewhere else and then spread to the bowel.
Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
On finding a potential compound for the treatment of colorectal cancer, researchers investigated whether dietary lutein/zeaxanthin, the major compounds found in carotenoid intake affect colorectal cancer risk in patients with a DICER1 rs3742330 polymorphism.
The experiment included 923 colorectal cancer patients and 1,846 controls based on eligibility criteria, that answered the semiquantitative food frequency questionnaire and the DICER1 rs3742330 genotype.
Based on the returned questionnaires differentiation, the highest quartile of lutein/zeaxanthin consumption was inversely associated with colorectal cancer risk.
In genotype analysis, patients who carry the G allele (AG + GG) showed a significantly reduced colorectal cancer incidence compared to AA carriers.
Furthermore, patients with the G allele (AG + GG) along with high lutein/zeaxanthin consumption were markedly associated with a decreased colorectal cancer risk, particularly in rectal cancer compared to AA carriers with low lutein/zeaxanthin intakes.
The results strongly suggested that carotenoids' major compounds lutein/zeaxanthin has a strong implication on the colorectal cancer risk in patients with the DICER1 rs3742330 genotype.
Dr. Kim J, the lead scientist after taking into account co and confounders wrote in the final report, "Colorectal cancer risk was related to an interactive effect between dietary lutein/zeaxanthin intake and the DICER1 rs3742330 polymorphism".
Taken altogether, carotenoids may be considered a remedy for the prevention and treatment of colorectal cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(2) Antiproliferative effects of carotenoids extracted from Chlorella ellipsoidea and Chlorella vulgaris on human colon cancer cells by Cha KH1, Koo SY, Lee DU. (PubMed)
Rectal cancer
(1) (1) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(2) Dietary Lutein Plus Zeaxanthin Intake and DICER1 rs3742330 A > G Polymorphism Relative to Colorectal Cancer Risk by Kim J1, Lee J1, Oh JH2, Chang HJ2, Sohn DK2, Kwon O3, Shin A4, Kim J. (PubMed)
(3) Bowel (Colorectal ) Cancer by Kyle J. Norton
Cancer is a class of diseases associated with irregular cell growth in the tissue of organs.
The colon-rectum formed as a part of the digestive system is involved in the absorption of water from the small bowel contents and the breaking down of certain materials in the feces into substances which of them to be reabsorbed and reused by the body.
Colorectal cancer is cancer located in the colon or rectum caused by the alternation of cell DNA. Most cases of colorectal cancer begin in the cells on the surface of inner ling tissue in either the colon or rectum, before multiplying to form a tumor.
Colorectal cancer is a relatively very common and slowly growing and progressing cancer.
The disease is also the third most commonly diagnosed cancer in developed countries, including the US and Canada.
According to the statistics provided by the American Cancer Society, in the US,
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in 2019.
Additionally, colorectal cancer will also cause the death of 51,020 Americans in 2019.
Overall, the lifetime risk of colorectal cancer developing is 1 in 22 (4.49%) in men and 1 in 24 (4.15%) in women.
Besides adenocarcinomas, the common type of colorectal cancer originated in epithelium tissues and squamous cells that make up the bowel lining together with the gland cells, other types of colorectal tumors include* Carcinoid
Carcinoid is an unusual type of slow-growth neuroendocrine tumor in the hormone-producing tissue in the digestive system. The condition may look benign but can spread to other parts of the body as they grow
* Leiomyosarcomas
Leiomyosarcomas are a rare and resistant type of colorectal cancer and are generally not very responsive to chemotherapy or radiation. They are a malignant abnormal mass of tissue of smooth muscles of the colon, comprising between 5–10% of soft tissue sarcomas.
* Lymphomas
Bowel lymphomas are rare and more likely to start in the rectum rather in the colon. Many patients with lymphomas are diagnosed in the late stage and already spread to other organs.
* Melanomas
Melanomas are rare malignant tumors of cells that produce dark pigment. This type of bowel cancer usually originates from somewhere else and then spread to the bowel.
Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.
On finding a potential compound for the treatment of colorectal cancer, researchers investigated whether dietary lutein/zeaxanthin, the major compounds found in carotenoid intake affect colorectal cancer risk in patients with a DICER1 rs3742330 polymorphism.
The experiment included 923 colorectal cancer patients and 1,846 controls based on eligibility criteria, that answered the semiquantitative food frequency questionnaire and the DICER1 rs3742330 genotype.
Based on the returned questionnaires differentiation, the highest quartile of lutein/zeaxanthin consumption was inversely associated with colorectal cancer risk.
In genotype analysis, patients who carry the G allele (AG + GG) showed a significantly reduced colorectal cancer incidence compared to AA carriers.
Furthermore, patients with the G allele (AG + GG) along with high lutein/zeaxanthin consumption were markedly associated with a decreased colorectal cancer risk, particularly in rectal cancer compared to AA carriers with low lutein/zeaxanthin intakes.
The results strongly suggested that carotenoids' major compounds lutein/zeaxanthin has a strong implication on the colorectal cancer risk in patients with the DICER1 rs3742330 genotype.
Dr. Kim J, the lead scientist after taking into account co and confounders wrote in the final report, "Colorectal cancer risk was related to an interactive effect between dietary lutein/zeaxanthin intake and the DICER1 rs3742330 polymorphism".
Taken altogether, carotenoids may be considered a remedy for the prevention and treatment of colorectal cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(2) Antiproliferative effects of carotenoids extracted from Chlorella ellipsoidea and Chlorella vulgaris on human colon cancer cells by Cha KH1, Koo SY, Lee DU. (PubMed)
Rectal cancer
(1) (1) Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition by Leenders M1, Leufkens AM, Siersema PD, van Duijnhoven FJ, Vrieling A, Hulshof PJ, van Gils CH, Overvad K, Roswall N, Kyrø C, Boutron-Ruault MC, Fagerhazzi G, Cadeau C, Kühn T, Johnson T, Boeing H, Aleksandrova K, Trichopoulou A, Klinaki E, Androulidaki A, Palli D, Grioni S, Sacerdote C, Tumino R, Panico S, Bakker MF, Skeie G, Weiderpass E, Jakszyn P, Barricarte A, María Huerta J, Molina-Montes E, Argüelles M, Johansson I, Ljuslinder I, Key TJ, Bradbury KE, Khaw KT, Wareham NJ, Ferrari P, Duarte-Salles T, Jenab M, Gunter MJ, Vergnaud AC, Wark PA, Bueno-de-Mesquita HB. (PubMed)
(2) Dietary Lutein Plus Zeaxanthin Intake and DICER1 rs3742330 A > G Polymorphism Relative to Colorectal Cancer Risk by Kim J1, Lee J1, Oh JH2, Chang HJ2, Sohn DK2, Kwon O3, Shin A4, Kim J. (PubMed)
(3) Bowel (Colorectal ) Cancer by Kyle J. Norton
#PolyherbalPpreparation From #Ashwagandha Exhibits Immunomodulatory Effects Against HIV Infection, Researchers Say
Kyle J. Norton
Human immunodeficiency virus -1 (HIV-1) is one of 2 types of HIV precipitated by acquired immunodeficiency syndrome (AIDS), transmitted through direct contact with HIV-infected body fluids, including blood, semen, and genital secretions,...
Human immunodeficiency virus HIV-1 is the most widespread type worldwide that can lead to acquired immunodeficiency syndrome (AIDS).
Acquired immunodeficiency syndrome (AIDS) is a chronic condition caused by the infection of the human immunodeficiency virus (HIV).
According to statistics, AIDS is the fifth leading cause of death in the US.
People between the ages of 25 and 44 in the United States are at substantially higher risk compared to other age groups.
Approximately 36.7 million people worldwide lived with HIV/AIDS in 2016, including, 2.1 million children less than 15 years of age.
According to epidemiological studies, people who serval sexual partners are the most at risk of HIV infection.
However, the virus can also transmit through infected blood transfusion, from infected mothers to children.
Most people infected by the HIV virus may experience symptoms of fever, muscle aches, and joint pain similar to those of influenza in the early stage of the viral attacks.
According to epidemiological studies, people who have serval sexual partners are the most at risk of HIV infection.
However, the virus can also transmit through infected blood transfusion, from infected mothers to children.
If untreated, the virus will slowly multiply and destroy the cells of the immune system, leading to chronic signs and symptoms of fever, fatigue, and swollen lymph nodes,...
If an infected individual has the numbers of T-cell count below 200, the person is considered to have AIDs.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the prevention of infectious diseases, researchers examined the clinical efficacy and safety of a new polyherbal preparation, Immu-25, in HIV-infected patients.
The open-label pilot study. included 36 patients (10 female, 26 male) with a mean age of 35 +/-10 years, with confirmed HIV infection with a CD4 count <500 cells/microL, and received two capsules of the test drug twice daily for 18 months.
According to the results of the study, the polyherbal preparation produced good symptomatic improvement within 6 months with an increase in mean (95% CI) weight from 58 (53-64)kg to 63 (56-69)kg, 64 (58-72)kg and 68 (62-74)kg after 6, 12 and 18 months of treatment, respectively.
The application decreased the incidence and severity of symptoms such as diarrhea, fatigue, anorexia, cough, and fever in the participants.
Furthermore, there was a decrease in the mean (95% CI) viral load from 326 438 (428 600-186 420) copies/mL to 180 495 (258 300-124 000) copies/mL and 22 069 (42 100-16 000) copies/mL after 6 and 12 months of treatment, respectively.
Most importantly, the decrease in viral load was associated with an increase in mean (95% CI) CD4 count from a baseline of 243 (203-388) cells/microL to 336 (263-486) cells/microL after 6 months of therapy, and this continued to rise to 527 (285-767) cells/microL (p < 0.001) and 618 (362-1012) cells/microL (p < 0.001) after 12 and 18 months of treatment, respectively.
However, mild gastrointestinal adverse effects had been reported by some of the participants.
Based on the evidence, researchers said, "herbal drug may have a good immunomodulatory effect and has potential as a co-therapeutic agent in the management of HIV infection. Further studies are warranted to confirm its therapeutic potential".
Taken altogether, Ashwagandha may be considered a supplement for the prevention and treatment of HIV infection, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of the antiretroviral activity of a new polyherbal drug (Immu-25) in patients with HIV infection by Usha PR1, Naidu MU, Raju YS. (PubMed)
Human immunodeficiency virus -1 (HIV-1) is one of 2 types of HIV precipitated by acquired immunodeficiency syndrome (AIDS), transmitted through direct contact with HIV-infected body fluids, including blood, semen, and genital secretions,...
Human immunodeficiency virus HIV-1 is the most widespread type worldwide that can lead to acquired immunodeficiency syndrome (AIDS).
Acquired immunodeficiency syndrome (AIDS) is a chronic condition caused by the infection of the human immunodeficiency virus (HIV).
According to statistics, AIDS is the fifth leading cause of death in the US.
People between the ages of 25 and 44 in the United States are at substantially higher risk compared to other age groups.
Approximately 36.7 million people worldwide lived with HIV/AIDS in 2016, including, 2.1 million children less than 15 years of age.
According to epidemiological studies, people who serval sexual partners are the most at risk of HIV infection.
However, the virus can also transmit through infected blood transfusion, from infected mothers to children.
Most people infected by the HIV virus may experience symptoms of fever, muscle aches, and joint pain similar to those of influenza in the early stage of the viral attacks.
According to epidemiological studies, people who have serval sexual partners are the most at risk of HIV infection.
However, the virus can also transmit through infected blood transfusion, from infected mothers to children.
If untreated, the virus will slowly multiply and destroy the cells of the immune system, leading to chronic signs and symptoms of fever, fatigue, and swollen lymph nodes,...
If an infected individual has the numbers of T-cell count below 200, the person is considered to have AIDs.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In the urgency to discover a natural ingredient for the prevention of infectious diseases, researchers examined the clinical efficacy and safety of a new polyherbal preparation, Immu-25, in HIV-infected patients.
The open-label pilot study. included 36 patients (10 female, 26 male) with a mean age of 35 +/-10 years, with confirmed HIV infection with a CD4 count <500 cells/microL, and received two capsules of the test drug twice daily for 18 months.
According to the results of the study, the polyherbal preparation produced good symptomatic improvement within 6 months with an increase in mean (95% CI) weight from 58 (53-64)kg to 63 (56-69)kg, 64 (58-72)kg and 68 (62-74)kg after 6, 12 and 18 months of treatment, respectively.
The application decreased the incidence and severity of symptoms such as diarrhea, fatigue, anorexia, cough, and fever in the participants.
Furthermore, there was a decrease in the mean (95% CI) viral load from 326 438 (428 600-186 420) copies/mL to 180 495 (258 300-124 000) copies/mL and 22 069 (42 100-16 000) copies/mL after 6 and 12 months of treatment, respectively.
Most importantly, the decrease in viral load was associated with an increase in mean (95% CI) CD4 count from a baseline of 243 (203-388) cells/microL to 336 (263-486) cells/microL after 6 months of therapy, and this continued to rise to 527 (285-767) cells/microL (p < 0.001) and 618 (362-1012) cells/microL (p < 0.001) after 12 and 18 months of treatment, respectively.
However, mild gastrointestinal adverse effects had been reported by some of the participants.
Based on the evidence, researchers said, "herbal drug may have a good immunomodulatory effect and has potential as a co-therapeutic agent in the management of HIV infection. Further studies are warranted to confirm its therapeutic potential".
Taken altogether, Ashwagandha may be considered a supplement for the prevention and treatment of HIV infection, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of the antiretroviral activity of a new polyherbal drug (Immu-25) in patients with HIV infection by Usha PR1, Naidu MU, Raju YS. (PubMed)
#Phytochemical #Alliin Inhibits #Cardiotoxicity through Its Antixodaint Activity, Scientists Show
Kyle J. Norton
Cardiotoxicity is a condition caused by toxins accumulated in the heart that leads to damage to the heart muscle.
Cardiotoxicity reduced the heart's pumping blood capability, leading to a decrease in oxygen-rich blood to nourish the body tissues and organs.
The most common symptoms of cardiotoxicity, are tiredness fatigue, chronic cough, water retention and shortness of breath.
If you have experienced some of the aforementioned symptoms that can be healed within a week or 2, please check with your doctor to rule out the possibility.
The most common causes of cardiotoxicity are associated with patients receiving chemotherapy and intake of certain medications. However, infection, excessive alcohol consumption, medical conditions such as diabetes and thyroid disease, high blood pressure, and thiamine and Vitamin B deficiency have also been found to induce cardiotoxicity.
Some researchers suggested that the promotion of a high-fat diet over the past few decades that facilitate widespread obesity may increase the cardiotoxicity risk of obese who are treated by chemotherapy.
Dr. Mitra MS, the lead scientist said, "Often, chemotherapy by doxorubicin (Adriamycin) is limited due to life-threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity".
And, "HFD-induced obese rats are highly sensitized to doxorubicin-induced cardiotoxicity".
In other words, non-obese patients who follow the recommended diet before taking chemotherapy are for the treatment of cancer are less sensitive to doxorubicin-induced cardiotoxicity compared to a high-fat diet obese.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound with cardioprotective activity, researchers examined the effect of S-allyl cysteine sulphoxide (SACS) in isoproterenol (ISO)-induced cardiotoxicity in male Wistar rats.
The study included myocardial infarction induced by subcutaneous injection of ISO (150 mg/kg) once a day for 2 days followed by SACS (40 and 80 mg/kg) as pretreatment orally daily for a period of 35 days using an intragastric tube.
SACS pretreatment showed significantly lowered levels of free radicals and increased antioxidant activities of mitochondrial superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), and glutathione (GSH).
Furthermore, SACS pretreatment not only decreased the levels of mitochondrial cholesterol, free fatty acids (FFAs), triglycerides (TGs), and calcium, associated with plaque accumulation and the activity of xanthine oxidase (XOD) involved the production of the free radicals in the heart, but also increased significantly the levels of mitochondrial phospholipids of the inner membrane of the heart against damage.
Moreover, pretreatment of SACS also protected the heart mitochondrial fraction by increasing the activities of isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), alpha-ketoglutarate dehydrogenase (alpha-KGDH), NADH-dehydrogenase, and cytochrome C-oxidase.
Interestingly, oral administration of SACS for a period of 35 days showed no cardio effect in normal control rats.
In other words, SACS modulated heart function against mitochondrial cardiotoxicity without affecting the heart function in healthy control.
Based on the findings researchers said, "The effect at a dose of SACS 80 mg/kg was more effective than the dose 40 mg/kg. The results of the study conclude that SACS protects the mitochondria of the ISO-induced myocardial-infarcted rats".
In order to know more information about SACS cardioprotective activity, researchers examined the preventive role of SACS on glycoproteins and hematology in experimentally induced myocardial infarction in rats for 2 days.
Injection of SACS restored the abnormally significant increase in the levels of serum iron, uric acid and blood glucose, Na(+) and Ca(2+) characterized by heart damage and elevated blood glucose.
Furthermore, the significant decrease in the levels of plasma iron binding capacity, serum total protein, albumin/globulin ratio, heart K(+), and heart glycogen induced by isoproterenol (ISO) associated with heart tissues damage were also inhibited by the treatment of SACS in myocardial infarcted rats.
Moreover, SACS also modulated the immune response in the production of pro-inflammatory cytokines induced by isoproterenol (ISO) toxicity.
Additional differentiation of the results suggested that oral pretreatment with SACS (40 and 80 mg kg(-1)) daily for a period of 35 days prevents cardiotoxicity by improving all the biochemical parameters studied in ISO-induced rats.
Taken altogether, alliin may be considered a supplement for the prevention and treatment of cardiotoxicity, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Preventive effect of S-allyl cysteine sulphoxide (Alliin) on mitochondrial dysfunction in normal and isoproterenol-induced cardiotoxicity in male Wistar rats: a histopathological study by Sangeetha T1, Darlin Quine S. (PubMed)
(2) Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol induced myocardial infarction in male Wistar rats by Sangeetha T1, Quine SD. (PubMed)
(3) High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity by Mitra MS1, Donthamsetty S, White B, Mehendale HM. (PubMed)
Cardiotoxicity is a condition caused by toxins accumulated in the heart that leads to damage to the heart muscle.
Cardiotoxicity reduced the heart's pumping blood capability, leading to a decrease in oxygen-rich blood to nourish the body tissues and organs.
The most common symptoms of cardiotoxicity, are tiredness fatigue, chronic cough, water retention and shortness of breath.
If you have experienced some of the aforementioned symptoms that can be healed within a week or 2, please check with your doctor to rule out the possibility.
The most common causes of cardiotoxicity are associated with patients receiving chemotherapy and intake of certain medications. However, infection, excessive alcohol consumption, medical conditions such as diabetes and thyroid disease, high blood pressure, and thiamine and Vitamin B deficiency have also been found to induce cardiotoxicity.
Some researchers suggested that the promotion of a high-fat diet over the past few decades that facilitate widespread obesity may increase the cardiotoxicity risk of obese who are treated by chemotherapy.
Dr. Mitra MS, the lead scientist said, "Often, chemotherapy by doxorubicin (Adriamycin) is limited due to life-threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity".
And, "HFD-induced obese rats are highly sensitized to doxorubicin-induced cardiotoxicity".
In other words, non-obese patients who follow the recommended diet before taking chemotherapy are for the treatment of cancer are less sensitive to doxorubicin-induced cardiotoxicity compared to a high-fat diet obese.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound with cardioprotective activity, researchers examined the effect of S-allyl cysteine sulphoxide (SACS) in isoproterenol (ISO)-induced cardiotoxicity in male Wistar rats.
The study included myocardial infarction induced by subcutaneous injection of ISO (150 mg/kg) once a day for 2 days followed by SACS (40 and 80 mg/kg) as pretreatment orally daily for a period of 35 days using an intragastric tube.
SACS pretreatment showed significantly lowered levels of free radicals and increased antioxidant activities of mitochondrial superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), and glutathione (GSH).
Furthermore, SACS pretreatment not only decreased the levels of mitochondrial cholesterol, free fatty acids (FFAs), triglycerides (TGs), and calcium, associated with plaque accumulation and the activity of xanthine oxidase (XOD) involved the production of the free radicals in the heart, but also increased significantly the levels of mitochondrial phospholipids of the inner membrane of the heart against damage.
Moreover, pretreatment of SACS also protected the heart mitochondrial fraction by increasing the activities of isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), alpha-ketoglutarate dehydrogenase (alpha-KGDH), NADH-dehydrogenase, and cytochrome C-oxidase.
Interestingly, oral administration of SACS for a period of 35 days showed no cardio effect in normal control rats.
In other words, SACS modulated heart function against mitochondrial cardiotoxicity without affecting the heart function in healthy control.
Based on the findings researchers said, "The effect at a dose of SACS 80 mg/kg was more effective than the dose 40 mg/kg. The results of the study conclude that SACS protects the mitochondria of the ISO-induced myocardial-infarcted rats".
In order to know more information about SACS cardioprotective activity, researchers examined the preventive role of SACS on glycoproteins and hematology in experimentally induced myocardial infarction in rats for 2 days.
Injection of SACS restored the abnormally significant increase in the levels of serum iron, uric acid and blood glucose, Na(+) and Ca(2+) characterized by heart damage and elevated blood glucose.
Furthermore, the significant decrease in the levels of plasma iron binding capacity, serum total protein, albumin/globulin ratio, heart K(+), and heart glycogen induced by isoproterenol (ISO) associated with heart tissues damage were also inhibited by the treatment of SACS in myocardial infarcted rats.
Moreover, SACS also modulated the immune response in the production of pro-inflammatory cytokines induced by isoproterenol (ISO) toxicity.
Additional differentiation of the results suggested that oral pretreatment with SACS (40 and 80 mg kg(-1)) daily for a period of 35 days prevents cardiotoxicity by improving all the biochemical parameters studied in ISO-induced rats.
Taken altogether, alliin may be considered a supplement for the prevention and treatment of cardiotoxicity, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Preventive effect of S-allyl cysteine sulphoxide (Alliin) on mitochondrial dysfunction in normal and isoproterenol-induced cardiotoxicity in male Wistar rats: a histopathological study by Sangeetha T1, Darlin Quine S. (PubMed)
(2) Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol induced myocardial infarction in male Wistar rats by Sangeetha T1, Quine SD. (PubMed)
(3) High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity by Mitra MS1, Donthamsetty S, White B, Mehendale HM. (PubMed)
#Herbal #Arctostaphylos uva-ursi InhibitsType 4 Hypersensitivity Caused by #ContactDermatitis, Scientists Find
Kyle J. Norton
Scientists may have found a herbal medicine for the prevention and treatment of type 4 hypersensitivity with no side effects, according to studies.
Type 4 allergy or type 4 hypersensitivity is often called delayed-type hypersensitivity as the reaction takes several days to develop.
In other words, instead of happening right the way as that of other types, type 4 hypersensitivity typically develops at least 48 hours after exposure to an antigen.
The process that develops type 4 hypersensitivity involved the activation of the white blood cell cells in stimulating the release of cytokines and chemokines, and macrophages and cytotoxic CD8+ T cells associated with the body's adaptive immune response.
Compared to other types of allergy mediated by the antibody, type 4 allergy is a cell-mediated response.
Type 4 hypersensitivity can induce allergic contact dermatitis, occurred at the site where the antigen contacts the skin, then spread to other regions through contamination of the antigen.
Type 4 hypersensitivity is caused by atopic dermatitis, lung diseases associated with hypersensitivity, type 2 diabetes, and inflammation of the thyroid gland.
Treatment of type 4 hypersensitivity is totally depending on the severity of the disease. however, the most appropriate approach is to avoid the offending antigen.
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc.
The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In the concern of the widespread Type IV hypersensitivity caused by contact dermatitis, researchers at Kinki University examined the combined effect of arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng. (Bearberry leaf) and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema, and adjuvant-induced arthritis.
Injection of arbutin at a dose of 50 mg/kg 24 h after the application rapidly decreased the swelling of type IV allergic sheep-induced edema and adjuvant-induced arthritis by picryl chloride (PC-CD) compared to no reaction at the divided doses of 50 mg/kg.
Arbutin (p.o.) plus indomethacin (s.c.) exerted highly inhibitory effects on the swelling of PC-CD and sheep red cell delayed-type hypersensitivity (SRBC-DTH) compared to that of indomethacin alone.
Furthermore, arbutin (p.o.) and indomethacin (s.c.) in a given portion were simultaneously administered, the inhibitory effect was more potent than that of indomethacin alone in both carrageenin-induced edema and adjuvant-induced arthritis.
The results clearly suggested that arbutin may increase the inhibitory action of indomethacin on PC-CD, and SRBC-DTH against type 4 hypersensitivity.
Moreover, in the comparison of water extract (UW-ext) from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf) on the antiallergic and anti-inflammatory activities of dexamethasone ointment, researchers found one or 2% UW-ext ointment did not inhibit the ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema.
However, combined with dexamethasone ointment (0.005 or 0.025%), UW-ext augmented the inhibitory effect of dexamethasone ointment (0.005 or 0.025%) on these allergic and inflammatory models with no side effects.
These findings showed that not all parts of herbal Arctostaphylos uva-ursi process anti-type 4 allergies, but combined with other therapy all parts augmented the significant anti-allergic and inflammatory activity with no side effects.
Additionally, the investigation of the antitype 4 allergies properties of the combined effect of 50% methanolic extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) and prednisolone also showed similar results as illustrated by the above 2 studies.
U-ext did not show an inhibitory effect on the swelling induced by PC-CD in divided doses of 100mg/kg immediately before and 16 h after the application of PC-CD, while it exhibited a significant therapeutic effect at a dose of 100 mg/kg or more once 24 h after the application.
Injection of the combination of U-ext (p.o.) and prednisolone (s.c.) simultaneously administered, exerted a greater inhibitory effect compared to that of prednisolone alone.
Researchers at the above studies wrote in the final report, "Bearberry leaf possesses a therapeutic effect against immuno-inflammation induced by PC-CD and also increases the inhibitory effect of prednisolone, and its active principle may be arbutin".
Taken together, herbal Herbal Arctostaphylos uva-ursi (Bearberry) may be considered a functional remedy for the prevention and combined with primary medicines for the treatment of type 4 hypersensitivity with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].[Article in Japanese] by Matsuda H, Nakamura S, Tanaka T, Kubo M.(PubMed)
(2) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. III. The combined effect of arbutin and indomethacin on immuno-inflammation].[Article in Japanese] by Matsuda H, Tanaka T, Kubo M.(PubMed)
(3) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. I. Combined effect of 50% methanolic extract from Arctostaphylosuva-ursi (L.) Spreng. (bearberry leaf) and prednisolone on immuno-inflammation].[Article in Japanese] by Kubo M, Ito M, Nakata H, Matsuda H.(PubMed)
Scientists may have found a herbal medicine for the prevention and treatment of type 4 hypersensitivity with no side effects, according to studies.
Type 4 allergy or type 4 hypersensitivity is often called delayed-type hypersensitivity as the reaction takes several days to develop.
In other words, instead of happening right the way as that of other types, type 4 hypersensitivity typically develops at least 48 hours after exposure to an antigen.
The process that develops type 4 hypersensitivity involved the activation of the white blood cell cells in stimulating the release of cytokines and chemokines, and macrophages and cytotoxic CD8+ T cells associated with the body's adaptive immune response.
Compared to other types of allergy mediated by the antibody, type 4 allergy is a cell-mediated response.
Type 4 hypersensitivity can induce allergic contact dermatitis, occurred at the site where the antigen contacts the skin, then spread to other regions through contamination of the antigen.
Type 4 hypersensitivity is caused by atopic dermatitis, lung diseases associated with hypersensitivity, type 2 diabetes, and inflammation of the thyroid gland.
Treatment of type 4 hypersensitivity is totally depending on the severity of the disease. however, the most appropriate approach is to avoid the offending antigen.
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc.
The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In the concern of the widespread Type IV hypersensitivity caused by contact dermatitis, researchers at Kinki University examined the combined effect of arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng. (Bearberry leaf) and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema, and adjuvant-induced arthritis.
Injection of arbutin at a dose of 50 mg/kg 24 h after the application rapidly decreased the swelling of type IV allergic sheep-induced edema and adjuvant-induced arthritis by picryl chloride (PC-CD) compared to no reaction at the divided doses of 50 mg/kg.
Arbutin (p.o.) plus indomethacin (s.c.) exerted highly inhibitory effects on the swelling of PC-CD and sheep red cell delayed-type hypersensitivity (SRBC-DTH) compared to that of indomethacin alone.
Furthermore, arbutin (p.o.) and indomethacin (s.c.) in a given portion were simultaneously administered, the inhibitory effect was more potent than that of indomethacin alone in both carrageenin-induced edema and adjuvant-induced arthritis.
The results clearly suggested that arbutin may increase the inhibitory action of indomethacin on PC-CD, and SRBC-DTH against type 4 hypersensitivity.
Moreover, in the comparison of water extract (UW-ext) from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf) on the antiallergic and anti-inflammatory activities of dexamethasone ointment, researchers found one or 2% UW-ext ointment did not inhibit the ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema.
However, combined with dexamethasone ointment (0.005 or 0.025%), UW-ext augmented the inhibitory effect of dexamethasone ointment (0.005 or 0.025%) on these allergic and inflammatory models with no side effects.
These findings showed that not all parts of herbal Arctostaphylos uva-ursi process anti-type 4 allergies, but combined with other therapy all parts augmented the significant anti-allergic and inflammatory activity with no side effects.
Additionally, the investigation of the antitype 4 allergies properties of the combined effect of 50% methanolic extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) and prednisolone also showed similar results as illustrated by the above 2 studies.
U-ext did not show an inhibitory effect on the swelling induced by PC-CD in divided doses of 100mg/kg immediately before and 16 h after the application of PC-CD, while it exhibited a significant therapeutic effect at a dose of 100 mg/kg or more once 24 h after the application.
Injection of the combination of U-ext (p.o.) and prednisolone (s.c.) simultaneously administered, exerted a greater inhibitory effect compared to that of prednisolone alone.
Researchers at the above studies wrote in the final report, "Bearberry leaf possesses a therapeutic effect against immuno-inflammation induced by PC-CD and also increases the inhibitory effect of prednisolone, and its active principle may be arbutin".
Taken together, herbal Herbal Arctostaphylos uva-ursi (Bearberry) may be considered a functional remedy for the prevention and combined with primary medicines for the treatment of type 4 hypersensitivity with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].[Article in Japanese] by Matsuda H, Nakamura S, Tanaka T, Kubo M.(PubMed)
(2) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. III. The combined effect of arbutin and indomethacin on immuno-inflammation].[Article in Japanese] by Matsuda H, Tanaka T, Kubo M.(PubMed)
(3) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. I. Combined effect of 50% methanolic extract from Arctostaphylosuva-ursi (L.) Spreng. (bearberry leaf) and prednisolone on immuno-inflammation].[Article in Japanese] by Kubo M, Ito M, Nakata H, Matsuda H.(PubMed)
#HealthyFood #Fenel is a Great Source of Antioxidants in the Inhibition of #Oxidativestress, Scientists Find
Kyle J. Norton
Fennel may be the next generative functional food with the potency in blocking the overexpression of free radicals in the induction of chronic illness, some scientists suggested.
Free radicals are highly reactive molecules with unpaired electrons that cause oxidation by stealing an electron from other molecules to give rise to a chain activity. Once free radical starts its domino effect, it can not be stopped until two free radical species react with each other to form a stable, non-radical adduct or are inhibited by the presence of antioxidants.
Antioxidants, on the other hand, are stable molecules that inhibit oxidation caused by free radicals.
The relationship between free radicals and antioxidant are summarized by Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health ", "A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence the application of an external source of antioxidants can assist in coping with this oxidative stress".
These explanations suggested that the intake of antioxidants from the food sources in the stimulation of antioxidant enzymes in the body is beneficial in maintaining good health, However, the doctors continued, "Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years".
Overexpression of free radicals or imbalance of the ratio of free radicals and antioxidants in the body can initiate oxidative stress. A prolonged period of oxidative stress in the human body plays a major part in the development of chronic and degenerative illnesses such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, and cardiovascular and neurodegenerative diseases.
Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The functional herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, relieve PMS,...
Fennel is an excellent source of natural antioxidants and contributed to the daily antioxidant diet. The functional food is found to process a free radical scavenging activity, particularly in the application of its phenolic and flavonoids.
In the examine the effects of fennel essential oil in the presence of overexpression of free radicals, researchers found, that injection of the oil exerts a strong antioxidant activity in comparison with butyrated hydroxyanisole and butylated hydroxytoluene., however, injection of ethanol and water extracts of fennel showed less effective compared to essential oil.
Furthermore, in the evaluation of the essential oils of the fruits of three organically grown cultivars of Egyptian fennel (Foeniculum vulgare var. azoricum, Foeniculum vulgare var. dulce, and Foeniculum vulgare var. vulgare) in antibacterial and antioxidant effects, researchers showed that all three cultivars contain a great source of trans-Anethole, estragole, fenchone, and limonene.
All phytochemicals demonstrated significant activity in free radical scavenging, inhibited lipid peroxidation, and metal chelation.
Additional differentiation suggested that essential oils from the azoricum and dulce cultivars were more effective antioxidants than that from the vulgare cultivar and essential oils from 3 species display similar antimicrobial activities against two species of fungi, two species of Gram-negative and two species of Gram-positive bacteria.
More importantly, in the examine the effect of essential oil on fennel (Foeniculum vulgare) lipophilic secondary metabolites, researchers at the Avicenna Tajik State Medical University, discovered that
* The oil exhibited moderate antioxidant activities.
* The antioxidants in the essential oil are found to protect the healthy cells and stimulate the expression of free radicals in exerting cytotoxic activity against HeLa (human cervical cancer), Caco-2 (human colorectal adenocarcinoma), MCF-7 (human breast adenocarcinoma), CCRF-CEM (human T lymphoblast leukemia) and CEM/ADR5000 (adriamycin resistant leukemia) cancer cell lines;
* The most effective of the IC50 values are between 30-210 mg L-1.
These results suggested essential oil from fennel is processed as a great source of antioxidants with the function of balancing the ratio of free radicals in the body, thus preventing the initiation of oxidative stress.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chemical composition, antimicrobial and antioxidant activities of essential oils from organically cultivated fennel cultivars by Shahat AA1, Ibrahim AY, Hendawy SF, Omer EA, Hammouda FM, Abdel-Rahman FH, Saleh MA(PubMed)
(3) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M8(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)
Fennel may be the next generative functional food with the potency in blocking the overexpression of free radicals in the induction of chronic illness, some scientists suggested.
Free radicals are highly reactive molecules with unpaired electrons that cause oxidation by stealing an electron from other molecules to give rise to a chain activity. Once free radical starts its domino effect, it can not be stopped until two free radical species react with each other to form a stable, non-radical adduct or are inhibited by the presence of antioxidants.
Antioxidants, on the other hand, are stable molecules that inhibit oxidation caused by free radicals.
The relationship between free radicals and antioxidant are summarized by Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health ", "A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence the application of an external source of antioxidants can assist in coping with this oxidative stress".
These explanations suggested that the intake of antioxidants from the food sources in the stimulation of antioxidant enzymes in the body is beneficial in maintaining good health, However, the doctors continued, "Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years".
Overexpression of free radicals or imbalance of the ratio of free radicals and antioxidants in the body can initiate oxidative stress. A prolonged period of oxidative stress in the human body plays a major part in the development of chronic and degenerative illnesses such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, and cardiovascular and neurodegenerative diseases.
Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The functional herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, relieve PMS,...
Fennel is an excellent source of natural antioxidants and contributed to the daily antioxidant diet. The functional food is found to process a free radical scavenging activity, particularly in the application of its phenolic and flavonoids.
In the examine the effects of fennel essential oil in the presence of overexpression of free radicals, researchers found, that injection of the oil exerts a strong antioxidant activity in comparison with butyrated hydroxyanisole and butylated hydroxytoluene., however, injection of ethanol and water extracts of fennel showed less effective compared to essential oil.
Furthermore, in the evaluation of the essential oils of the fruits of three organically grown cultivars of Egyptian fennel (Foeniculum vulgare var. azoricum, Foeniculum vulgare var. dulce, and Foeniculum vulgare var. vulgare) in antibacterial and antioxidant effects, researchers showed that all three cultivars contain a great source of trans-Anethole, estragole, fenchone, and limonene.
All phytochemicals demonstrated significant activity in free radical scavenging, inhibited lipid peroxidation, and metal chelation.
Additional differentiation suggested that essential oils from the azoricum and dulce cultivars were more effective antioxidants than that from the vulgare cultivar and essential oils from 3 species display similar antimicrobial activities against two species of fungi, two species of Gram-negative and two species of Gram-positive bacteria.
More importantly, in the examine the effect of essential oil on fennel (Foeniculum vulgare) lipophilic secondary metabolites, researchers at the Avicenna Tajik State Medical University, discovered that
* The oil exhibited moderate antioxidant activities.
* The antioxidants in the essential oil are found to protect the healthy cells and stimulate the expression of free radicals in exerting cytotoxic activity against HeLa (human cervical cancer), Caco-2 (human colorectal adenocarcinoma), MCF-7 (human breast adenocarcinoma), CCRF-CEM (human T lymphoblast leukemia) and CEM/ADR5000 (adriamycin resistant leukemia) cancer cell lines;
* The most effective of the IC50 values are between 30-210 mg L-1.
These results suggested essential oil from fennel is processed as a great source of antioxidants with the function of balancing the ratio of free radicals in the body, thus preventing the initiation of oxidative stress.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chemical composition, antimicrobial and antioxidant activities of essential oils from organically cultivated fennel cultivars by Shahat AA1, Ibrahim AY, Hendawy SF, Omer EA, Hammouda FM, Abdel-Rahman FH, Saleh MA(PubMed)
(3) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M8(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)
#Curcumin #Extract From #Herbal #Turmeric Inhibits Chronic Prostatitis through their Anti- Inflammatory Activity, Researchers Say
Kyle J. Norton
Prostatitis is a condition associated with the inflammation of the prostate and the areas around the prostate.
According to the statistics provided by the American Family Physician, approximately 8.2 percent of men in the US are living with prostatitis. The conditions account for 8 percent of visits to urologists, and up to 1 percent of visits to primary care physicians.
Believe it or not, in 2000, prostatitis cost over $84 million, including the charge of diagnosis and treatment.
The most common symptoms of prostatitis are painful, difficult, and/or frequent urinating, groin pain, rectal pain, abdominal pain and/or low back pain, fever, chills, and body aches.
In severe cases, patients may also experience symptoms of urethral discharge, painful ejaculation or sexual dysfunction, and blood in the urine.
The exact causes of prostatitis are not identified, some researchers suggested that nerve damage in the lower urinary tract caused by surgery or trauma to the area has been found to induce prostatitis in patients.
Conventionally, most cases of prostatitis are treated by antibiotics in cases of infection, alpha-blockers to relax the bladder neck, and muscle fibers, and anti-inflammatory medicine to ease pain and discomforts.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential and natural ingredient for the treatment of inflammatory diseases such as chronic prostatitis/ chronic pelvic pain syndrome type III (CP/CPPS), researchers examined the effect of turmeric on chronic bacterial prostatitis.
Phase II, the randomized, single-blinded, placebo-controlled clinical trial included 60 patients who were examined by the University of Catania from June 2015 to January 2016 we enrolled 60 consecutive due to CP/CPPS III.
At the end of the experiment, the treatment group showed a significant improvement in the National Institutes of Health Chronic Prostatitis Symptom Index, IIEF-5 (+ 3.5; p < 0.01), particularly other symptomatic parameters compared to placebo.
Participants were then allocated to receive treatment (Group A) or placebo(Group B). Treatment consisted of rectal suppositories of Curcumin extract 350 mg (95%) and Calendula extracts 80 mg (1 suppository/die for 1 month). Patients of Group B received 1 suppository/die for 1 month of placebo.
The efficacy of the treatment with Curcumin and Calendula was associated with the reduction of inflammatory cytokines and inflammatory cells.
Based on the findings, Dr. Morgia G, the lead researcher said, "In this phase II clinical trial, we showed the clinical efficacy of the treatment with Curcumin and Calendula in patients with CP/CPPS III".
Taken together, turmeric used alone or combined with Calendula may be considered supplements for the prevention and treatment of chronic bacterial prostatitis and chronic pelvic pain syndrome, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A phase II, randomized, single-blinded, placebo-controlled clinical trial on the efficacy of Curcumina and Calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III by Morgia G1, Russo GI, Urzì D, Privitera S, Castelli T, Favilla V, Cimino S. (PubMed)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)
Prostatitis is a condition associated with the inflammation of the prostate and the areas around the prostate.
According to the statistics provided by the American Family Physician, approximately 8.2 percent of men in the US are living with prostatitis. The conditions account for 8 percent of visits to urologists, and up to 1 percent of visits to primary care physicians.
Believe it or not, in 2000, prostatitis cost over $84 million, including the charge of diagnosis and treatment.
The most common symptoms of prostatitis are painful, difficult, and/or frequent urinating, groin pain, rectal pain, abdominal pain and/or low back pain, fever, chills, and body aches.
In severe cases, patients may also experience symptoms of urethral discharge, painful ejaculation or sexual dysfunction, and blood in the urine.
The exact causes of prostatitis are not identified, some researchers suggested that nerve damage in the lower urinary tract caused by surgery or trauma to the area has been found to induce prostatitis in patients.
Conventionally, most cases of prostatitis are treated by antibiotics in cases of infection, alpha-blockers to relax the bladder neck, and muscle fibers, and anti-inflammatory medicine to ease pain and discomforts.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential and natural ingredient for the treatment of inflammatory diseases such as chronic prostatitis/ chronic pelvic pain syndrome type III (CP/CPPS), researchers examined the effect of turmeric on chronic bacterial prostatitis.
Phase II, the randomized, single-blinded, placebo-controlled clinical trial included 60 patients who were examined by the University of Catania from June 2015 to January 2016 we enrolled 60 consecutive due to CP/CPPS III.
At the end of the experiment, the treatment group showed a significant improvement in the National Institutes of Health Chronic Prostatitis Symptom Index, IIEF-5 (+ 3.5; p < 0.01), particularly other symptomatic parameters compared to placebo.
Participants were then allocated to receive treatment (Group A) or placebo(Group B). Treatment consisted of rectal suppositories of Curcumin extract 350 mg (95%) and Calendula extracts 80 mg (1 suppository/die for 1 month). Patients of Group B received 1 suppository/die for 1 month of placebo.
The efficacy of the treatment with Curcumin and Calendula was associated with the reduction of inflammatory cytokines and inflammatory cells.
Based on the findings, Dr. Morgia G, the lead researcher said, "In this phase II clinical trial, we showed the clinical efficacy of the treatment with Curcumin and Calendula in patients with CP/CPPS III".
Taken together, turmeric used alone or combined with Calendula may be considered supplements for the prevention and treatment of chronic bacterial prostatitis and chronic pelvic pain syndrome, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A phase II, randomized, single-blinded, placebo-controlled clinical trial on the efficacy of Curcumina and Calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III by Morgia G1, Russo GI, Urzì D, Privitera S, Castelli T, Favilla V, Cimino S. (PubMed)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)
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