#Phloretin From #Apples or [6]-gingerol From Ginger SupplementationGinger Inhibit the Formation of AGEs Associated with the Onset of #Diabetes and #DiabeticComplications

Kyle J. Norton

Ginger may have a potential and profound effect in regulating abnormally high blood sugar, some scientists suggested. 

Hyperglycemia is a condition of abnormally high levels of glucose in the bloodstream.

According to the statistic, approximately, 30.3 million Americans, or 9.4% of the population, had diabetes. Approximately 1.25 million American children and adults have type 1 diabetes. And, hyperglycemia is a hallmark sign of diabetes(both type 1 diabetes and type 2 diabetes) and prediabetes.


Some researchers suggested that people who are living under prolonged periods of stress due to chronic illness or stress are associated with a higher risk of high blood sugar.

Others suggested that an unhealthy diet such as high in saturated and trans fat, red meat, processed food, and lack of physical exercise have many folds increased the risk for the onset of hyperglycemia.

In fact, shift workers accompanied by an unhealthy lifestyle are jointly associated with the risk of type 2 diabetes.

Dr. Shan Z, in the concerns of the rotating night shift work and lifestyle factors in the risk of diabetes, used the data of Nurses' Health Study (1988-2012) and Nurses' Health Study II (1991-2013) and compared to the 143 410 women without type 2 diabetes, cardiovascular disease, or cancer at baseline, said, " The multivariable-adjusted hazard ratios for type 2 diabetes were 1.31 (95% confidence interval 1.19 to 1.44) per five-year increment of the duration of rotating night shift work and 2.30 per unhealthy lifestyle factor (ever smoking, low diet quality, low physical activity, and overweight or obesity)".


"For the joint association of per five-year increment rotating night shift work and per unhealthy lifestyle factor with type 2 diabetes, the hazard ratio was 2.83 (2.15 to 3.73) with a significant additive interaction (P for interaction <0.001)".

How severe of the diabetes risk in nurses on the rotating shift accompanied by an unhealthy diet? According to the team, during 22-24 years of follow-up, 10 915 cases of incident type 2 diabetes occurred.

The risk of type 2 diabetes is even higher if each individual factor is also included.

These results clearly suggested that the onset of diabetes is not caused by a single factor but is associated with a group set of risk factors.

Luckily, most people with some of the above risk factors do not develop hyperglycemia or type 2 diabetes.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

In finding a natural ingredient and whole food for the treatment of diabetes and diabetes complications, researchers examine the action of ginger in the diabetic population.

Selected mice fed either a high-fat diet or a standard diet for a period of 17 weeks were given phloretin isolated from apples and [6]-gingerol isolated from ginger supplemented at two different doses.

Application of phloretin and [6]-gingerol inhibited the formation of AGEs by suppressing the receptor for advanced glycation end products (RAGE).

Where Advanced glycation end products are proteins or lipids that become glycated as a result of exposure to sugars. The products can substantially worsen certain chronic diseases such as diabetes.

Phloretin or [6]-gingerol supplementation significantly reduced plasma glucose, alanine aminotransferase, aspartate aminotransferase, AGEs, and insulin levels and enhanced GSH/GSSG ratio.

These results suggested that phloretin or [6]-gingerol supplementation not only inhibited the oxidative stress that causes abnormally high blood glucose but also improved insulin resistance against the onset of diabetes complications in mice fed with a high-fat diet.

Furthermore, the assessment of the effect of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus with the consumption of 1600 mg ginger versus 1600 mg wheat flour placebo daily for 12 weeks, also found that ginger reduced fasting plasma glucose, HbA1C, insulin, HOMA, triglyceride, total cholesterol, CRP and PGE₂ significantly compared with the placebo group (p < 0.05).

Ginger improved fasting glucose and parameters associated with the onset of insulin resistance without inducing any side effects.

Dr. Arablou T after taking into account co and confounders said, "Ginger improved insulin sensitivity and some fractions of lipid profile, and reduced CRP and PGE₂ in type 2 diabetic patients. Therefore ginger can be considered an effective treatment for the prevention of diabetes complications".

Taken altogether, ginger may be considered a functional food for the prevention and treatment of diabetes and diabetes complications induced by abnormally high blood glucose.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway by Sampath C1, Rashid MR1, Sang S2, Ahmedna M. (PubMed)
(2) The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(3) Zerumbone, a Phytochemical of Subtropical Ginger, Protects against Hyperglycemia-Induced Retinal Damage in Experimental Diabetic Rats by Tzeng TF1, Liou SS2, Tzeng YC3, Liu IM. (PubMed).
(4) Rotating night shift work and adherence to an unhealthy lifestyle in predicting the risk of type 2 diabetes: results from two large US cohorts of female nurses by Shan Z1,2, Li Y2, Zong G2, Guo Y3,4, Li J2,3, Manson JE3,5, Hu FB2,3,6, Willett WC2,3,6, Schernhammer ES3,6,7, Bhupathiraju SN2, (PubMed)

#Phytochemical 3,3'-Diindolylmethane Inhibits Parameters Associated wiht An Increased Risk of #BreastCancer, According to Studies

Kyle J. Norton

Cancer is a class of diseases in which a group of cells grow and multiply disorderly and uncontrollably in our body.

Breast cancer (malignant breast neoplasm) is a medical condition characterized by irregular cell growth in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

There are also rare cases that breast cancer started in other areas of the breast.

In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the US and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Breast cancer is first noticed as a painless lump in the breast or armpit and is most often discovered by the women themselves.

In some cases, breast cancer can also be noticed by the woman partner or during the doctor a routine physical exam.

In the early stage of breast cancer, patients may experience symptoms of a lump (mass) in the breast. and in the armpit (lymph nodes), nipple discharge, inverted or retracted nipple, scaly or pitted skin on a nipple, persistent tenderness of the breast, and unusual breast pain or discomfort.


If you experience some of the aforementioned symptoms, please check with your doctor right away to rule out the possibility. Breast cancer diagnosed in the early stage have a 5-year survival rate of 100%.

However, at the advanced stage, due to the oversize of the tumor, patients may experience symptoms of bone pain (secondary tumors in bone), shortness of breath (secondary tumors in the lung) Headaches, neurological pain, or weakness (secondary tumors in the nervous system) accompanied by the general symptoms shared with other types of cancer.


Out of many risk factors associated with the onset of breast cancer, genetic preposition may be one of the major predictions of the disease.


Dr. Amir Mehrgou, the lead scientist said, "Early detection of mutation carriers in these genes, in turn, can play an important role in its prevention. Because this disease has a high prevalence in half of the global population, female screening of reported mutations in predisposing genes, which have been seen in breast cancer patients, seems necessary. In this review, a number of mutations in two predisposing genes (BRCA1 and BRCA2) occurred in patients with a family history,..".

In fact, women who carry the BRCA1 and BRCA2 genes have a 68% lifetime risk to develop breast cancer.

In seeking a potential compound for the treatment of breast cancer, researchers examined the promising 3,3'-Diindolylmethane (DIM) anticancer effects of breast cancer patients with high HER-2/neu levels.

DIM combined with Herceptin enhances the effectiveness of Herceptin by significantly reducing cancer cell viability, and increasing apoptosis-induction and inhibition of colony formation, compared to the use of the chemo drug alone.

The combination also induced cancer cell death by inhibiting the expression of proteins associated with the production of proinflammatory cytokines, cancer cell division, and proliferation and migration.

Furthermore, the combination also significantly exhibited the expression of miR-200, which plays an essential in blocking tumor cell invasion and metastasis and reduction of FoxM1 expression in the promotion of cancer cell proliferation.

Dr. Ahmad A, the lead scientist said, "DIM-plus Herceptin therapy could be translated to the clinic as a therapeutic modality to improve treatment outcome of patients with breast cancer, particularly for the patients whose tumors express high levels of HER-2/neu".

Moreover, in order to know more information about DIM anti-breast cancer activity, researchers investigated the bioactive compound against the transcription factor Forkhead Box M1 (FoxM1) associated with aggressive human carcinomas, including breast cancer.


3,3'-diindolylmethane (DIM), a nontoxic dietary chemopreventive agent showed to inhibit the FoxM1 in various breast cancer cell lines, according to the observation of gene transfection, real-time reverse transcription-PCR, and Western blotting.

Similar to the aforementioned results, DIM combined with Taxotere enhanced Taxotere-induced growth inhibition of breast cancer cells and decreased the invasive capacity of breast cancer cells compared to treatment alone.

Most importantly, the combination treatment also significantly inhibited tumor growth in severe immunodeficiency (SCID) mice,

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of breast cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3, 3'-Diindolylmethane enhances the effectiveness of Herceptin against HER-2/neu-expressing breast cancer cells by Ahmad A1, Ali S, Ahmed A, Ali AS, Raz A, Sakr WA, Rahman KM. (PubMed)
(2) 3,3'-Diindolylmethane enhances taxotere-induced growth inhibition of breast cancer cells through downregulation of FoxM1 by Ahmad A1, Ali S, Wang Z, Ali AS, Sethi S, Sakr WA, Raz A, Rahman KM. (PubMed)
(3) The importance of BRCA1 and BRCA2 gene mutations in breast cancer development by Amir Mehrgou 1 and Mansoureh Akouchekian. (PMC)

#CookedTomatoes or Lycopene Supplements Inhibit all Parameters Associated with the Onset of #OxidativeStress, Researchers Say

Kyle J. Norton

Oxidative stress is a condition characterized by overexpression of free radicals in the body.

In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants caused by abundant free radicals and low levels of antioxidant enzymes produced by the body.

A free radical is an unstable atom with a single electron on the outermost ring. Given its nature, free radicals readily donate or intercept an electron from another atom, leading to a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.

The antioxidant is a stable atom with a function to inhibit oxidation, and comes either from dietary sources or produced by the body.

In contrast to general belief, free radical is also needed in moderated amounts for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.

According to studies, in cancer, oxidative stress has been found to induce cytotoxicity used in chemotherapy for the treatment of cancer by killing cancer cells.

However, in a healthy person, oxidative stress is harmful because it not only induces cells lipid and protein oxidation but also causes the change of cell DNA, leading to diseases associated with oxidative stress including cancer, diabetes, and cardiovascular disease.

Ozone, certain pesticides, cleaners, cigarette smoke, radiation, and pollution are some of the risk factors associated with the increased risk of oxidative stress.

Based on the oxidative stress theory of aging oxidative stress, oxidative stress is also the main culprit contributing to aging in humans.

Dr. Ilaria Liguori, the lead scientist said, "Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages".


Tomato is red, edible fruit, genus Solanum, belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.


With an aim to find a potential compound for the treatment of diseases associated with oxidative stress researchers examined the efficacy of lycopene a carotenoid commonly found in tomatoes and tomato products.


A total of 23 healthy postmenopausal women, 50-60 years old, provided blood samples at baseline and following a one-month lycopene-depletion period according to the St. Michael's Hospital, Toronto, ON, Canada. PARTICIPANTS AND STUDY DESIGN.
Compared to the blood sample before and after experiment samples, a one-month lycopene-depletion period diet showed a significantly decreased antioxidant profile including serum lycopene, lutein/zeaxanthin, and glutathione peroxidase (GPx).

Furthermore, the diet also depressed levels of antioxidant enzymes superoxide dismutase (SOD), and catalase (CAT), significantly in the participants while increasing levels of lipid and protein oxidation.
In other words, a tomato restrictive diet increased the risk of diseases associated with oxidative stress in postmenopausal women due to the increase of ROS and depletion of antioxidants in the tissues.


In order to reveal more information about tomato's effect on oxidative stress, researchers conducted a study to determine whether lycopene would act as an antioxidant to decrease oxidative stress parameters.
The study included a total of 60 postmenopausal women, 50-60 years old, following a 1-month washout without lycopene consumption,.


After a month, the participants were randomly divided into groups with 15 members each consuming either : (1) regular tomato juice, (2) lycopene-rich tomato juice, (3) tomato Lyc-O-Mato lycopene capsules, or (4) placebo capsules, twice daily for total lycopene intakes of 30, 70, 30, and 0 mg/day respectively for 4 months.

According to the tested assays, for 4 months significantly increased serum lycopene compared to placebo.

Moreover, the total serum antioxidant capacity (TAC) and decreasing lipid and protein peroxidation were found to increase substantially in the groups treated with consumed juice or lycopene capsules compared to the placebo group.

Taken together, tomatoes and their major bioactive compound lycopene may be considered remedies for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.


Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose and acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausalwomen by Mackinnon ES1, Rao AV, Rao LG. (PubMed)
(2) Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women by Mackinnon ES1, Rao AV, Josse RG, Rao LG. (PubMed)
(3) Oxidative stress, aging, and diseases by Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6Domenico Bonaduce,1 and Pasquale Abete. (PMC)

#Honey Eardrops Exert a Strong Effect on the treatment of #EczematousExternalOtitis, Researchers Say

Kyle J. Norton

In seeking natural therapy with no side effects, scientists may have found a herbal medicine for the prevention and treatment of acute otitis externa, according to studies.

Acute otitis externa is a condition characterized by the inflammation of the ear canal. Most cases of acute acute otitis externa are associated with the infection by Pseudomonas aeruginosa and Staphylococcus aureus due to improper cleaning.

However, people with seborrhoeic dermatitis caused by inflammation of greasy areas of the skin can also lead to infection of the ears.

The most common symptoms of acute otitis include itching, canal edema, canal erythema, and otorrhea.

Most cases of acute otitis externa are healed within days with proper ear drops. However, there is a rare case where the disease may take weeks or months to recover.

Chronic otitis externa shares the common symptoms of the acute form, accompanied by water retention and severe ear pain, and temporary loss of hearing, due to building up thick and dry skin that can build up inside the ear canal, leading to narrowing of the ear canal.

Untreated chronic otitis externa can cause deafness.

Besides sharing the risk factors with the acute form, otitis externa can also be caused by infection due to the long-term use of hearing aids and earplugs.

Unlike the acute form, most cases of otitis externa are treated with steroid drops in addition to antibiotics accompanied by oral intake of pain medications such as ibuprofen.

Generally, oral antibiotics are not recommended, however, if the infection has spread beyond the ear canal, oral antibiotics may be applied.


According to the statistics, otitis externa affects 1–3% of people in America a year, and 95% of people's complaints of the condition are acute.

Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

In the finding of a natural ingredient for the treatment of eczematous external otitis, scientists investigated the antibacterial potential of medical honey eardrops as a treatment of eczematous external otitis.


15 patients diagnosed with recurrent eczematous external otitis were selected and treated with medical honey eardrops for 2 weeks.

Honey treatment resulted in less discomfort and itching and decreased signs of eczema with no side effects, according to assays.


Although honey eardrops showed a strong in vitro inhibitory activity against all tested strains, they did not eradicate Staphylococcus aureus infection.

Honey eardrops also reduced the visual analog scale of ear complaints, and a score of eczema, and increased the eradication of bacterial infection. Most patients in the study, are satisfied with the use of honey eardrops for the treatment of their eczematous external otitis.

Dr. Henatsch D, the lead scientist, after taking into account co and confounders said, "The results of this preliminary study indicate a possible role of honey eardrops in eczematous ear disease".

Taken together, honey may be considered a functional remedy for the treatment of eczematous external otitis, pending the confirmation of a larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Treatment of Recurrent Eczematous External Otitis with Honey Eardrops: A Proof-of-Concept Study by Henatsch D1, Nabuurs CH1, van de Goor RM1, Wolffs PF2, Stokroos RJ. (PubMed)
(2) Alternative Treatments for Atopic Dermatitis: An Update by Shi K1, Lio PA. (PubMed)
(2) Acute Otitis Externa: An Update by PAUL SCHAEFER, MD, PhD, and REGINALD F. BAUGH, MD. (AAFP)

#Antioxidant Lycopene Used Alone or Combined with Vitamin E Inhibit the Stress Markers Associated with #CognitiveDeficits, Researchers Suggest

Kyle J. Norton

Memory deficit is a condition that affects memory contributing to a significant impact on daily functioning.
Memory is an accumulated experience that binds together thoughts and impressions in your life from childhood to adulthood.

The most common disease associated with memory loss besides trauma is dementia, a class of neurodegenerative diseases that has been found to process the gradual loss of memory in the elderly due to the death of specific neurons.

Memory deficits can be acute. Short-term memory is a process that allows you to remember things temporarily, such as reading a book, or going shopping with a list in your mind.

Loss of short-term memory can be devastating. People with this condition can not remember the content in a task that they try to discuss with others

In other words, people with a weak working memory can’t remember what they wanted to say.

In chronic memory deficits or long-term memory loss, patients have trouble recalling information when they are needed. Aging has been found to be one of the major risk factors which weaken long-and short-term memory.

Chronic memory loss caused by psychological conditions such as stress, nutrient deficiency, depression, and medication can be reversible. However, the loss of neurons in the brain is one of the irreversible chronic memory deficits found in a large population in the elderly, such as patients with Alzheimer’s disease.

Memory impairment is a condition associated with a slow decline in memory, thinking, and reasoning skills. Over time, the condition can worsen enough to affect the quality of life and daily activity.

Some memory changes can be resolved on their own or cured by medical treatment. Others due to the loss of neuron and quantity capacity cannot be revered such as dementia.

According to statistics, every year over 7.7 million new cases are diagnosed. The disease is a leading cause of dependency and mental impairment among the elderly population.

Conventionally, there is no cure for dementia, treatment of irreversible memory impairment is focusing on improving the quality of life by delaying the progression of underlying diseases such as AD and PD.

Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In finding a natural compound for the treatment of oxidative stress effects in the pathogenesis of Alzheimer's disease (AD), researchers examined whether lycopene or lycopene/vitamin E could exert protective effects on memory deficit and oxidative stress in tau transgenic mice expressing P301L mutation.

The experiment included P301L transgenic mice randomly assigned to three groups: P301L group (P301L), P301L+lycopene (Lyc), and P301L+lycopene/vitamin E (Lyc+VE) with age-matched C57BL/6J mice as wild type controls (Con).

The P301L group showed significant spatial and passive memory impairments observed by elevated oxidative stress markers of malondialdehyde (MDA) levels and decreased levels of antioxidant enzymes produced by the host compared to the control.

According to neuro analysis, the P301L group also exhibited an increase of tau phosphorylation at Thr231/Ser235, Ser262, and Ser396 in the brain.

Supplementations of lycopene or lycopene/vitamin E administration significantly ameliorate memory deficits, by decreasing the levels of MDA concentrations and increasing the production of the GSH-Px activities.

Markedly, the lycopene or lycopene/vitamin E treatment groups also attenuated tau hyperphosphorylation at multiple AD-related sites.

These findings strongly suggested that lycopene or lycopene/vitamin E protects the integrity of the neurons against the increase of tau phosphorylation associated with neuronal cell dysfunction caused by oxidative stress through their antioxidant activity.

Based on the results, researchers wrote, " the combination of lycopene and vitamin E antioxidants acted in a synergistic fashion to bring significant effects against oxidative stress in tauopathies".

Taken altogether, lycopene found in tomatoes used alone or combined with vitamin E may be considered supplements for the prevention and treatment of cognitive deficits, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Lycopene Supplementation Improves Cognitive Performances in Tau Transgenic Mice Expressing P301L Mutation via Inhibiting Oxidative Stress and Tau Hyperphosphorylation by Yu L, Wang W, Pang W, Xiao Z, Jiang Y, Hong Y. (PubMed)
(2) Supplementation of lycopene attenuates oxidative stress-induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway by Zhao B1, Ren B1, Guo R1, Zhang W1, Ma S1, Yao Y1, Yuan T1, Liu Z1, Liu X. (PubMed)

Phytochemical #Indicaxanthin Incorporates Into the Redox Machinery of Beta-Thalassemia RBC and Defends the Cell from Oxidation Beta Thalassemia Anemia

Kyle J. Norton

Anemia is a medical condition associated with a lack of healthy red blood cells or hemoglobin in the blood.
Iron deficiency anemia is one of the most common anemia, caused by poor iron levels in the blood, leading to the reduced delivery of oxygen throughout the body.

People with a long-term deficiency of folate and vitamin B-12 which play a critical role in the production of healthy red blood cells are also at an increased risk of Amenia.

Patients with Beta-thalassemia minor have a slight lowering of the beta hemoglobin level in the blood similar to those with mild iron-deficiency anemia.

Beta thalassemia can be classified into
* Thalassemia minor, the mild case of anemia, is the most common anemia in people of Mediterranean descent. The blood cells of patients with thalassemia minor are smaller than normal blood cells and easily die off, causing not enough new blood cells to replace the red blood cell loss.

* Thalassemia major
Thalassemia major also called Cooley's anemia is an inherited disorder that affects the production of normal hemoglobin. Thalassemia major is a deadly disease without frequent blood transfusions, people with this kind of anemia may not survive because of iron building up in the heart and other organs, which can lead to heart failure.

The most common symptoms of beta-thalassemia are fatigue, weakness, or shortness of breath, a pale appearance or yellow color to the skin (jaundice), irritability, deformities of the facial bone, slow growth, a swollen abdomen, and dark urine.

There are many risk factors involved in the onset of the condition. Blood loss, such as from heavy menstrual bleeding, ulcer, cancer, and regular use of some over-the-counter pain relievers, especially aspirin are some of the most common prevalent risk factors.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an antioxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

Indicaxanthin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

In finding a potential compound for the treatment of beta-thalassemia red blood cells, researchers examined the antioxidant activity of indicaxanthin.

In vitro, human beta-thalassemia RBCs submitted to oxidative hemolysis by cumene hydroperoxide, application of indicaxanthin at 1.0-10 microM enhanced the resistance to hemolysis associated with the destruction of red blood cells in a dose-dependent manner.

Furthermore, the phytochemical also exerted a significant antioxidant activity by preventing lipid and hemoglobin (Hb) oxidation and enhancing the levels of vitamin E and GSH depletion.

Moreover, indicaxanthin also stimulated the recovery of the soluble cell compartment of the RBCs in the blood from thalassemia patients.

According to the A spectrophotometric study, the antioxidant also showed to reduce the reactive intermediate that makes an abnormal form of hemoglobin in solution caused by the oxidative stress, compared to those of Trolox or vitamin C.

Based on the findings, researchers said, "Collectively our results demonstrate that indicaxanthin can be incorporated into the redox machinery of beta-thalassemia RBC and defend the cell from oxidation".

Taken altogether, indicaxanthin may be considered a remedy for the prevention and treatment of beta-thalassemia anemia, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells by Tesoriere L1, Allegra M, Butera D, Gentile C, Livrea MA. (PubMed)

#Turmeric Processes #Antiproliferative, Anti-inflammatory by Inhibiting #Angiogenic Activity, Researchers Say

Kyle J. Norton

Angiogenesis is the process that promotes the formation of new blood vessels involving many factors including the migration, growth, and differentiation of endothelial cells.

In normal cells, angiogenesis is important for the cells to obtain nutrients and metabolites through the newly forming small blood vessels. Angiogenesis has been found to process a therapeutic effect for the treatment of ischemic heart disease, peripheral arterial disease, and wound healing.

Dr. Papetti M, the lead scientist at the Tufts University School of Medicine said, "Normal angiogenesis ensures that developing or healing tissues receive an adequate supply of nutrients".
In cancers, angiogenesis stimulated by the tumor cells has been associated with tumors proliferation and metastasis".

More precisely, the angiogenesis process is a function of a double sword. On one hand, the process provides an ideal condition for the treatment of diseases and wound healing. On the other hand, it promotes invasive and overgrowth tumors.

Dr. Papetti M continued, "Tumor cells induce the formation of new blood supply from the preexisting vasculature, and this affords tumor cells the ability to survive and propagate in a hostile environment"

Collectively, " both normal and tumor-induced neovascularization fulfill the essential role of satisfying the metabolic demands of tissue".

Therefore, by inhibiting the process of blood vessel formation of the tumor, cancer may be curable.

Dr. Dai X, the lead researcher in the study of "Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis" showed, "trichosanthin TCS, ( an immunosuppressive and anti-tumor protein) inhibits murine B-cell lymphoma growth by anti-angiogenesis was reported. First, TCS inhibits tumor growth and prolonged survival significantly in vivo, and TCS depressed the formation of new blood vessels around the tumor in a dose-dependent manner".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient for the treatment of cancer, researchers examined the Trivalent arsenic [As(III)] induced damaging effects on human health such as angiogenesis.

Epidemiologically, Trivalent arsenic [As(III)] has been found to induce the development of cardiovascular disease, diabetes, cancer, and angiogenesis.

According to tested analysis, the administration of curcumin, an active ingredient in dietary turmeric has been shown to demonstrate potent antiproliferative, anti-inflammatory by inhibiting angiogenic activity.

In HCT-116 human colon cancer cells exposed to As(III), both curcumin and turmeric inhibit the expression of vascular endothelial growth factor associated with the promotion of the growth of new blood vessels from the existing blood vessels.

In the chicken chorioallantoic membrane assay model, curcumin or turmeric. also inhibited the extensive increase in blood vessel density.

Based on the findings, researchers wrote, " the findings reported here strongly suggest that turmeric and curcumin can dramatically attenuate the process of angiogenesis induced by low As(III) concentrations".

Taken altogether, turmeric processed with a high amount of bioactive compound curcumin may be considered a supplement for the prevention and treatment of cancer associated with angiogenesis, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo by Pantazis P1, Varman A, Simpson-Durand C, Thorpe J, Ramalingam S, Subramaniam D, Houchen C, Ihnat M, Anant S, Ramanujam RP. (PubMed)
(2) Angiogenesis in Cancer by Naoyo Nishida,1,2 Hirohisa Yano,1 Takashi Nishida,3 Toshiharu Kamura,2 andMasamichi Kojiro. (PMC)
(3) Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis by Xingbin Dai,1,2 Pengjun Jiang,2 Yanhua Ji,3 Xuejun Zhu,2 and Xuemei Sun2. (PMC)