Tuesday, 22 August 2023

#CookedTomatoes or Lycopene Supplements Inhibit all Parameters Associated with the Onset of #OxidativeStress, Researchers Say

Kyle J. Norton

Oxidative stress is a condition characterized by overexpression of free radicals in the body.

In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants caused by abundant free radicals and low levels of antioxidant enzymes produced by the body.

A free radical is an unstable atom with a single electron on the outermost ring. Given its nature, free radicals readily donate or intercept an electron from another atom, leading to a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.

The antioxidant is a stable atom with a function to inhibit oxidation, and comes either from dietary sources or produced by the body.

In contrast to general belief, free radical is also needed in moderated amounts for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.

According to studies, in cancer, oxidative stress has been found to induce cytotoxicity used in chemotherapy for the treatment of cancer by killing cancer cells.

However, in a healthy person, oxidative stress is harmful because it not only induces cells lipid and protein oxidation but also causes the change of cell DNA, leading to diseases associated with oxidative stress including cancer, diabetes, and cardiovascular disease.

Ozone, certain pesticides, cleaners, cigarette smoke, radiation, and pollution are some of the risk factors associated with the increased risk of oxidative stress.

Based on the oxidative stress theory of aging oxidative stress, oxidative stress is also the main culprit contributing to aging in humans.

Dr. Ilaria Liguori, the lead scientist said, "Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages".


Tomato is red, edible fruit, genus Solanum, belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.


With an aim to find a potential compound for the treatment of diseases associated with oxidative stress researchers examined the efficacy of lycopene a carotenoid commonly found in tomatoes and tomato products.


A total of 23 healthy postmenopausal women, 50-60 years old, provided blood samples at baseline and following a one-month lycopene-depletion period according to the St. Michael's Hospital, Toronto, ON, Canada. PARTICIPANTS AND STUDY DESIGN.
Compared to the blood sample before and after experiment samples, a one-month lycopene-depletion period diet showed a significantly decreased antioxidant profile including serum lycopene, lutein/zeaxanthin, and glutathione peroxidase (GPx).

Furthermore, the diet also depressed levels of antioxidant enzymes superoxide dismutase (SOD), and catalase (CAT), significantly in the participants while increasing levels of lipid and protein oxidation.
In other words, a tomato restrictive diet increased the risk of diseases associated with oxidative stress in postmenopausal women due to the increase of ROS and depletion of antioxidants in the tissues.


In order to reveal more information about tomato's effect on oxidative stress, researchers conducted a study to determine whether lycopene would act as an antioxidant to decrease oxidative stress parameters.
The study included a total of 60 postmenopausal women, 50-60 years old, following a 1-month washout without lycopene consumption,.


After a month, the participants were randomly divided into groups with 15 members each consuming either : (1) regular tomato juice, (2) lycopene-rich tomato juice, (3) tomato Lyc-O-Mato lycopene capsules, or (4) placebo capsules, twice daily for total lycopene intakes of 30, 70, 30, and 0 mg/day respectively for 4 months.

According to the tested assays, for 4 months significantly increased serum lycopene compared to placebo.

Moreover, the total serum antioxidant capacity (TAC) and decreasing lipid and protein peroxidation were found to increase substantially in the groups treated with consumed juice or lycopene capsules compared to the placebo group.

Taken together, tomatoes and their major bioactive compound lycopene may be considered remedies for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.


Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose and acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausalwomen by Mackinnon ES1, Rao AV, Rao LG. (PubMed)
(2) Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women by Mackinnon ES1, Rao AV, Josse RG, Rao LG. (PubMed)
(3) Oxidative stress, aging, and diseases by Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6Domenico Bonaduce,1 and Pasquale Abete. (PMC)

#Honey Eardrops Exert a Strong Effect on the treatment of #EczematousExternalOtitis, Researchers Say

Kyle J. Norton

In seeking natural therapy with no side effects, scientists may have found a herbal medicine for the prevention and treatment of acute otitis externa, according to studies.

Acute otitis externa is a condition characterized by the inflammation of the ear canal. Most cases of acute acute otitis externa are associated with the infection by Pseudomonas aeruginosa and Staphylococcus aureus due to improper cleaning.

However, people with seborrhoeic dermatitis caused by inflammation of greasy areas of the skin can also lead to infection of the ears.

The most common symptoms of acute otitis include itching, canal edema, canal erythema, and otorrhea.

Most cases of acute otitis externa are healed within days with proper ear drops. However, there is a rare case where the disease may take weeks or months to recover.

Chronic otitis externa shares the common symptoms of the acute form, accompanied by water retention and severe ear pain, and temporary loss of hearing, due to building up thick and dry skin that can build up inside the ear canal, leading to narrowing of the ear canal.

Untreated chronic otitis externa can cause deafness.

Besides sharing the risk factors with the acute form, otitis externa can also be caused by infection due to the long-term use of hearing aids and earplugs.

Unlike the acute form, most cases of otitis externa are treated with steroid drops in addition to antibiotics accompanied by oral intake of pain medications such as ibuprofen.

Generally, oral antibiotics are not recommended, however, if the infection has spread beyond the ear canal, oral antibiotics may be applied.


According to the statistics, otitis externa affects 1–3% of people in America a year, and 95% of people's complaints of the condition are acute.

Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

In the finding of a natural ingredient for the treatment of eczematous external otitis, scientists investigated the antibacterial potential of medical honey eardrops as a treatment of eczematous external otitis.


15 patients diagnosed with recurrent eczematous external otitis were selected and treated with medical honey eardrops for 2 weeks.

Honey treatment resulted in less discomfort and itching and decreased signs of eczema with no side effects, according to assays.


Although honey eardrops showed a strong in vitro inhibitory activity against all tested strains, they did not eradicate Staphylococcus aureus infection.

Honey eardrops also reduced the visual analog scale of ear complaints, and a score of eczema, and increased the eradication of bacterial infection. Most patients in the study, are satisfied with the use of honey eardrops for the treatment of their eczematous external otitis.

Dr. Henatsch D, the lead scientist, after taking into account co and confounders said, "The results of this preliminary study indicate a possible role of honey eardrops in eczematous ear disease".

Taken together, honey may be considered a functional remedy for the treatment of eczematous external otitis, pending the confirmation of a larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Treatment of Recurrent Eczematous External Otitis with Honey Eardrops: A Proof-of-Concept Study by Henatsch D1, Nabuurs CH1, van de Goor RM1, Wolffs PF2, Stokroos RJ. (PubMed)
(2) Alternative Treatments for Atopic Dermatitis: An Update by Shi K1, Lio PA. (PubMed)
(2) Acute Otitis Externa: An Update by PAUL SCHAEFER, MD, PhD, and REGINALD F. BAUGH, MD. (AAFP)

#Antioxidant Lycopene Used Alone or Combined with Vitamin E Inhibit the Stress Markers Associated with #CognitiveDeficits, Researchers Suggest

Kyle J. Norton

Memory deficit is a condition that affects memory contributing to a significant impact on daily functioning.
Memory is an accumulated experience that binds together thoughts and impressions in your life from childhood to adulthood.

The most common disease associated with memory loss besides trauma is dementia, a class of neurodegenerative diseases that has been found to process the gradual loss of memory in the elderly due to the death of specific neurons.

Memory deficits can be acute. Short-term memory is a process that allows you to remember things temporarily, such as reading a book, or going shopping with a list in your mind.

Loss of short-term memory can be devastating. People with this condition can not remember the content in a task that they try to discuss with others

In other words, people with a weak working memory can’t remember what they wanted to say.

In chronic memory deficits or long-term memory loss, patients have trouble recalling information when they are needed. Aging has been found to be one of the major risk factors which weaken long-and short-term memory.

Chronic memory loss caused by psychological conditions such as stress, nutrient deficiency, depression, and medication can be reversible. However, the loss of neurons in the brain is one of the irreversible chronic memory deficits found in a large population in the elderly, such as patients with Alzheimer’s disease.

Memory impairment is a condition associated with a slow decline in memory, thinking, and reasoning skills. Over time, the condition can worsen enough to affect the quality of life and daily activity.

Some memory changes can be resolved on their own or cured by medical treatment. Others due to the loss of neuron and quantity capacity cannot be revered such as dementia.

According to statistics, every year over 7.7 million new cases are diagnosed. The disease is a leading cause of dependency and mental impairment among the elderly population.

Conventionally, there is no cure for dementia, treatment of irreversible memory impairment is focusing on improving the quality of life by delaying the progression of underlying diseases such as AD and PD.

Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In finding a natural compound for the treatment of oxidative stress effects in the pathogenesis of Alzheimer's disease (AD), researchers examined whether lycopene or lycopene/vitamin E could exert protective effects on memory deficit and oxidative stress in tau transgenic mice expressing P301L mutation.

The experiment included P301L transgenic mice randomly assigned to three groups: P301L group (P301L), P301L+lycopene (Lyc), and P301L+lycopene/vitamin E (Lyc+VE) with age-matched C57BL/6J mice as wild type controls (Con).

The P301L group showed significant spatial and passive memory impairments observed by elevated oxidative stress markers of malondialdehyde (MDA) levels and decreased levels of antioxidant enzymes produced by the host compared to the control.

According to neuro analysis, the P301L group also exhibited an increase of tau phosphorylation at Thr231/Ser235, Ser262, and Ser396 in the brain.

Supplementations of lycopene or lycopene/vitamin E administration significantly ameliorate memory deficits, by decreasing the levels of MDA concentrations and increasing the production of the GSH-Px activities.

Markedly, the lycopene or lycopene/vitamin E treatment groups also attenuated tau hyperphosphorylation at multiple AD-related sites.

These findings strongly suggested that lycopene or lycopene/vitamin E protects the integrity of the neurons against the increase of tau phosphorylation associated with neuronal cell dysfunction caused by oxidative stress through their antioxidant activity.

Based on the results, researchers wrote, " the combination of lycopene and vitamin E antioxidants acted in a synergistic fashion to bring significant effects against oxidative stress in tauopathies".

Taken altogether, lycopene found in tomatoes used alone or combined with vitamin E may be considered supplements for the prevention and treatment of cognitive deficits, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Lycopene Supplementation Improves Cognitive Performances in Tau Transgenic Mice Expressing P301L Mutation via Inhibiting Oxidative Stress and Tau Hyperphosphorylation by Yu L, Wang W, Pang W, Xiao Z, Jiang Y, Hong Y. (PubMed)
(2) Supplementation of lycopene attenuates oxidative stress-induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway by Zhao B1, Ren B1, Guo R1, Zhang W1, Ma S1, Yao Y1, Yuan T1, Liu Z1, Liu X. (PubMed)

Phytochemical #Indicaxanthin Incorporates Into the Redox Machinery of Beta-Thalassemia RBC and Defends the Cell from Oxidation Beta Thalassemia Anemia

Kyle J. Norton

Anemia is a medical condition associated with a lack of healthy red blood cells or hemoglobin in the blood.
Iron deficiency anemia is one of the most common anemia, caused by poor iron levels in the blood, leading to the reduced delivery of oxygen throughout the body.

People with a long-term deficiency of folate and vitamin B-12 which play a critical role in the production of healthy red blood cells are also at an increased risk of Amenia.

Patients with Beta-thalassemia minor have a slight lowering of the beta hemoglobin level in the blood similar to those with mild iron-deficiency anemia.

Beta thalassemia can be classified into
* Thalassemia minor, the mild case of anemia, is the most common anemia in people of Mediterranean descent. The blood cells of patients with thalassemia minor are smaller than normal blood cells and easily die off, causing not enough new blood cells to replace the red blood cell loss.

* Thalassemia major
Thalassemia major also called Cooley's anemia is an inherited disorder that affects the production of normal hemoglobin. Thalassemia major is a deadly disease without frequent blood transfusions, people with this kind of anemia may not survive because of iron building up in the heart and other organs, which can lead to heart failure.

The most common symptoms of beta-thalassemia are fatigue, weakness, or shortness of breath, a pale appearance or yellow color to the skin (jaundice), irritability, deformities of the facial bone, slow growth, a swollen abdomen, and dark urine.

There are many risk factors involved in the onset of the condition. Blood loss, such as from heavy menstrual bleeding, ulcer, cancer, and regular use of some over-the-counter pain relievers, especially aspirin are some of the most common prevalent risk factors.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an antioxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

Indicaxanthin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

In finding a potential compound for the treatment of beta-thalassemia red blood cells, researchers examined the antioxidant activity of indicaxanthin.

In vitro, human beta-thalassemia RBCs submitted to oxidative hemolysis by cumene hydroperoxide, application of indicaxanthin at 1.0-10 microM enhanced the resistance to hemolysis associated with the destruction of red blood cells in a dose-dependent manner.

Furthermore, the phytochemical also exerted a significant antioxidant activity by preventing lipid and hemoglobin (Hb) oxidation and enhancing the levels of vitamin E and GSH depletion.

Moreover, indicaxanthin also stimulated the recovery of the soluble cell compartment of the RBCs in the blood from thalassemia patients.

According to the A spectrophotometric study, the antioxidant also showed to reduce the reactive intermediate that makes an abnormal form of hemoglobin in solution caused by the oxidative stress, compared to those of Trolox or vitamin C.

Based on the findings, researchers said, "Collectively our results demonstrate that indicaxanthin can be incorporated into the redox machinery of beta-thalassemia RBC and defend the cell from oxidation".

Taken altogether, indicaxanthin may be considered a remedy for the prevention and treatment of beta-thalassemia anemia, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells by Tesoriere L1, Allegra M, Butera D, Gentile C, Livrea MA. (PubMed)

#Turmeric Processes #Antiproliferative, Anti-inflammatory by Inhibiting #Angiogenic Activity, Researchers Say

Kyle J. Norton

Angiogenesis is the process that promotes the formation of new blood vessels involving many factors including the migration, growth, and differentiation of endothelial cells.

In normal cells, angiogenesis is important for the cells to obtain nutrients and metabolites through the newly forming small blood vessels. Angiogenesis has been found to process a therapeutic effect for the treatment of ischemic heart disease, peripheral arterial disease, and wound healing.

Dr. Papetti M, the lead scientist at the Tufts University School of Medicine said, "Normal angiogenesis ensures that developing or healing tissues receive an adequate supply of nutrients".
In cancers, angiogenesis stimulated by the tumor cells has been associated with tumors proliferation and metastasis".

More precisely, the angiogenesis process is a function of a double sword. On one hand, the process provides an ideal condition for the treatment of diseases and wound healing. On the other hand, it promotes invasive and overgrowth tumors.

Dr. Papetti M continued, "Tumor cells induce the formation of new blood supply from the preexisting vasculature, and this affords tumor cells the ability to survive and propagate in a hostile environment"

Collectively, " both normal and tumor-induced neovascularization fulfill the essential role of satisfying the metabolic demands of tissue".

Therefore, by inhibiting the process of blood vessel formation of the tumor, cancer may be curable.

Dr. Dai X, the lead researcher in the study of "Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis" showed, "trichosanthin TCS, ( an immunosuppressive and anti-tumor protein) inhibits murine B-cell lymphoma growth by anti-angiogenesis was reported. First, TCS inhibits tumor growth and prolonged survival significantly in vivo, and TCS depressed the formation of new blood vessels around the tumor in a dose-dependent manner".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient for the treatment of cancer, researchers examined the Trivalent arsenic [As(III)] induced damaging effects on human health such as angiogenesis.

Epidemiologically, Trivalent arsenic [As(III)] has been found to induce the development of cardiovascular disease, diabetes, cancer, and angiogenesis.

According to tested analysis, the administration of curcumin, an active ingredient in dietary turmeric has been shown to demonstrate potent antiproliferative, anti-inflammatory by inhibiting angiogenic activity.

In HCT-116 human colon cancer cells exposed to As(III), both curcumin and turmeric inhibit the expression of vascular endothelial growth factor associated with the promotion of the growth of new blood vessels from the existing blood vessels.

In the chicken chorioallantoic membrane assay model, curcumin or turmeric. also inhibited the extensive increase in blood vessel density.

Based on the findings, researchers wrote, " the findings reported here strongly suggest that turmeric and curcumin can dramatically attenuate the process of angiogenesis induced by low As(III) concentrations".

Taken altogether, turmeric processed with a high amount of bioactive compound curcumin may be considered a supplement for the prevention and treatment of cancer associated with angiogenesis, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo by Pantazis P1, Varman A, Simpson-Durand C, Thorpe J, Ramalingam S, Subramaniam D, Houchen C, Ihnat M, Anant S, Ramanujam RP. (PubMed)
(2) Angiogenesis in Cancer by Naoyo Nishida,1,2 Hirohisa Yano,1 Takashi Nishida,3 Toshiharu Kamura,2 andMasamichi Kojiro. (PMC)
(3) Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis by Xingbin Dai,1,2 Pengjun Jiang,2 Yanhua Ji,3 Xuejun Zhu,2 and Xuemei Sun2. (PMC)

#Hydrophilic or #Lipophilic #Tomato Ketchup #Extracts Inhibit Gene Expression Associated with Pro-Inflammatory Cytokines , Researchers Say

Kyle J. Norton


Inflammation is a natural response by the immune system to protect the body against the invasion of stimuli or foreign pathogens.

In other words, the white blood cells on the first line of defense of the immune system after sensing the danger of an infection in the body through a message from the brain stimulate the production of the palette to cover the site of injury or damage and inflammatory cytokines to kill off all pathogens before they can cause harm to the body.

Most cases of infection are stopped at the acute phase. The wound or injury is slowly recovered.

However, in severe cases, particularly in people with a weakened immune system, the inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, leading to low-grade chronic inflammation.

Diseases associated with low-grade inflammation include diabetes and cardiovascular.

Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.

In the US, chronic inflammatory diseases affect more than 50 million Americans each year.

Dr. Roma Pahwa in the classification of chronic inflammation wrote, "Chronic inflammation is also referred to as slow, long-term inflammation lasting for prolonged periods of several months to years. Generally, the extent and effects of chronic inflammation vary with the cause of the injury and the ability of the body to repair and overcome the damage".


And, "(The causes of chronic inflammation are) Failure of eliminating the agent causing acute inflammation, ..., Exposure to a low level of a particular irritant or foreign materials,...An autoimmune disorder,... Recurrent episodes of acute inflammation,... Inflammatory and biochemical inducers"

Tomato is red, edible fruit, genus Solanum, and belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In finding a potential compound for the treatment of inflammatory diseases researchers examined the effect of tomato ketchup extracts and bioactive from tomato ketchup on human monocytes and vascular endothelial cells (HUVEC).

HUVEC selected for the study were pre-treated for 1 h with either individual bioactive (7.5 µM lycopene, 1.4 µM α-tocopherol, or 55 µM ascorbic acid) or a combination of these three compounds, or with the hydrophilic or lipophilic tomato ketchup extracts or with the two extracts combined.

According to the tested assays, tomato ketchup extracts significantly reduced gene expression and pro-inflammatory cytokines TNF-α and IL-8 in HUVEC after inducing inflammation.

Furthermore, levels of anti-inflammatory release were increased observed by the expression of anti-inflammatory cytokine IL-10.


The effects were correlated with the reduction of IL-8 production in the presence of the test compounds and extracts.
In other words, lycopene found in tomato extract is one of the major bioactive compounds that induce the anti-inflammatory effect, and α-tocopherol and ascorbic acid appeared to strengthen the anti-inflammatory effect of lycopene.

In order to obtain more information about tomato anti-inflammatory activity, researchers analyzed the potential protective effects of phytochemicals in tomatoes on inflammation.

According to the nitric oxide (NO) assay, tomato extract exhibited an anti-inflammatory effect by inhibiting the NO production in LPS-stimulated RAW264 macrophages.
Levels of pro-inflammatory cytokines were significantly decreased after the injection of tomatoes.

The efficacy of tomatoes was attributed to the bioactive compound RF52 in the inhibition of the production of these proinflammatory mediators.

Dr. Kim YI, the lead scientist said, "These results suggest that RF52 from tomatoes may have the potential to suppress inflammation by inhibiting the production of NO or proinflammatory cytokines during the interaction between adipocytes and macrophages".

Taken together, tomatoes may be considered functional food for the prevention and treatment of inflammatory diseases, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protection against chemotaxis in the anti-inflammatory effect of bioactive from tomato ketchup by Hazewindus M1, Haenen GR1, Weseler AR1, Bast A. (PubMed)
(2) Tomato extract suppresses the production of proinflammatory mediators induced by the interaction between adipocytes and macrophages by Kim YI1, Mohri S, Hirai S, Lin S, Goto T, Ohyane C, Sakamoto T, Takahashi H, Shibata D, Takahashi N, Kawada T. (PubMed)
(3) Chronic Inflammation by Roma Pahwa; Ishwarlal Jialal. (NCBI)

Foods and Herbs That Process Anti High Blood Pressure Activity with No Side Effects, Scientists Say

Kyle J. Norton

In seeking natural therapy with no side effects, scientists may have a herbal remedy for normalizing blood pressure, according to studies.

Hypertension is a chronic condition caused by abnormally high blood pressure.

High blood pressure is a condition of a cluster of metabolic syndrome associated with the increased risk of heart disease and stroke.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

In high blood pressure individuals, due to the elevated blood pressure in your arteries, the heart has to work harder than normal to pump blood through the blood vessels.

In low blood pressure individuals, the reduced blood pressure in the arteries drops can cause the heart to pump blood at a slower rate than normal.


According to the standard guidelines, the levels of blood pressure are normal if it is more than 120 over 80 and less than 140 over 90 (120/80-140/90).


People with blood pressure lower than 120/80 are considered normal without being accompanied by symptoms of light-head or dizziness.

According to the statistics provided by the CDC, in the U.S. 29% or 100 million adults have hypertension during 2015–2016 and hypertension prevalence increased with age and was 33.2% among those aged 40–59 and 63.1% among those aged 60 and over.


Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener.

Researchers in the course of finding a natural ingredient for the treatment of high blood pressure investigated the safety and effect of intrapulmonary administration (by inhalation) of 60 % honey solution, 10% dextrose, or distilled water in normal or diabetic subjects.

Twenty-four healthy subjects, 16 patients with type 1 diabetes mellitus and six patients with hypertension were selected to participate in the study.


Twelve healthy subjects were subjected to distilling water inhalation for 10 min, and after one week they received inhalation of honey solution (60% wt/v) for 10 min. Another 12 healthy subjects received inhalation of 10% dextrose for 10 min.

Honey treatment showed a mild reduction of blood pressure compared to no change in another group.

From a time perspective, systolic and diastolic blood pressure was reduced by honey inhalation in hypertensive patients at 60 and 120 min.

After taking into account co and confounders, researchers said, "Honey inhalation was safe and effective in reducing...elevated blood pressure in hypertensive patients".

Moreover, in order to obtain more information on honey antihypertensive activity, researchers investigated the aqueous extract obtained from the mixture of the fresh leaf of Persea Americana, stems, and a fresh leaf of Cymbopogon citrus, fruits of Citrus medica, and honey on ethanol and sucrose-induced hypertension in rats.


Rats included in the study were divided into eight groups of 6 rats each and daily treated for 5 weeks. The control group received distilled water (1 mL/kg) while rats of groups 2, 3, and 4 received ethanol 40 degrees (3 g/kg/day), 10% sucrose as drinking water, and the two substances respectively.

The remaining groups received additional sucrose and ethanol, the aqueous extract (50, 100, and 150 mg/kg) and nifedipine (10 mg/kg) respectively.


The group treated with ethanol and sucrose showed a significantly (p < 0.001) increased blood pressure and heart rate compared to distilled water-treated rats.


Chronic treatment of ethanol and sucrose also exerted significantly decreased the activities of antioxidant enzymes produced by the host, observed by the levels of superoxide dismutase (SOD) and catalase (CAT) and elevated levels of oxidative stress observed by the stress marker malondialdehyde (MDA) levels.

However, administration of the aqueous extract or nifedipine prevented all changes caused by chronic ethanol and sucrose, including hemodynamic, biochemical, oxidative, and histological impairments.

The finding clearly suggested that aqueous extract including honey possesses antihypertensive activity by the improvement of biochemical and oxidative status, through its antioxidant property.

Taken together, honey used alone or combined with other herbs may be considered anti-hypertension functional remedies with no side effects, pending the confirmation of a large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Intrapulmonary administration of the natural honey solution, hyperosmolar dextrose, or hypoosmolar distill water to normal individuals and to patients with type-2 diabetes mellitus or hypertension: their effects on blood glucose level, plasma insulin, and C-peptide, blood pressure and peaked expiratory flow rate by Al-Waili N1. (PubMed)
(2) Antihypertensive potential of the aqueous extract which combines the leaf of Persea americana Mill. (Lauraceae), stems and leaf of Cymbopogon citratus (D.C) Stapf. (Poaceae), fruits of Citrus medical L. (Rutaceae) as well as honey in ethanol and sucrose experimental model by Dzeufiet PD1, Mogueo A, Bilanda DC, Aboubakar BF, Tédong L, Dimo T, Kamtchouing P. (PubMed)