Kyle J. Norton
Memory deficit is a condition that affects memory contributing to a significant impact on daily functioning.
Memory is an accumulated experience that binds together thoughts and impressions in your life from childhood to adulthood.
The most common disease associated with memory loss besides trauma is dementia, a class of neurodegenerative diseases that has been found to process the gradual loss of memory in the elderly due to the death of specific neurons.
Memory deficits can be acute. Short-term memory is a process that allows you to remember things temporarily, such as reading a book, or going shopping with a list in your mind.
Loss of short-term memory can be devastating. People with this condition can not remember the content in a task that they try to discuss with others
In other words, people with a weak working memory can’t remember what they wanted to say.
In chronic memory deficits or long-term memory loss, patients have trouble recalling information when they are needed. Aging has been found to be one of the major risk factors which weaken long-and short-term memory.
Chronic memory loss caused by psychological conditions such as stress, nutrient deficiency, depression, and medication can be reversible. However, the loss of neurons in the brain is one of the irreversible chronic memory deficits found in a large population in the elderly, such as patients with Alzheimer’s disease.
Memory impairment is a condition associated with a slow decline in memory, thinking, and reasoning skills. Over time, the condition can worsen enough to affect the quality of life and daily activity.
Some memory changes can be resolved on their own or cured by medical treatment. Others due to the loss of neuron and quantity capacity cannot be revered such as dementia.
According to statistics, every year over 7.7 million new cases are diagnosed. The disease is a leading cause of dependency and mental impairment among the elderly population.
Conventionally, there is no cure for dementia, treatment of irreversible memory impairment is focusing on improving the quality of life by delaying the progression of underlying diseases such as AD and PD.
Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
In finding a natural compound for the treatment of oxidative stress effects in the pathogenesis of Alzheimer's disease (AD), researchers examined whether lycopene or lycopene/vitamin E could exert protective effects on memory deficit and oxidative stress in tau transgenic mice expressing P301L mutation.
The experiment included P301L transgenic mice randomly assigned to three groups: P301L group (P301L), P301L+lycopene (Lyc), and P301L+lycopene/vitamin E (Lyc+VE) with age-matched C57BL/6J mice as wild type controls (Con).
The P301L group showed significant spatial and passive memory impairments observed by elevated oxidative stress markers of malondialdehyde (MDA) levels and decreased levels of antioxidant enzymes produced by the host compared to the control.
According to neuro analysis, the P301L group also exhibited an increase of tau phosphorylation at Thr231/Ser235, Ser262, and Ser396 in the brain.
Supplementations of lycopene or lycopene/vitamin E administration significantly ameliorate memory deficits, by decreasing the levels of MDA concentrations and increasing the production of the GSH-Px activities.
Markedly, the lycopene or lycopene/vitamin E treatment groups also attenuated tau hyperphosphorylation at multiple AD-related sites.
These findings strongly suggested that lycopene or lycopene/vitamin E protects the integrity of the neurons against the increase of tau phosphorylation associated with neuronal cell dysfunction caused by oxidative stress through their antioxidant activity.
Based on the results, researchers wrote, " the combination of lycopene and vitamin E antioxidants acted in a synergistic fashion to bring significant effects against oxidative stress in tauopathies".
Taken altogether, lycopene found in tomatoes used alone or combined with vitamin E may be considered supplements for the prevention and treatment of cognitive deficits, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Lycopene Supplementation Improves Cognitive Performances in Tau Transgenic Mice Expressing P301L Mutation via Inhibiting Oxidative Stress and Tau Hyperphosphorylation by Yu L, Wang W, Pang W, Xiao Z, Jiang Y, Hong Y. (PubMed)
(2) Supplementation of lycopene attenuates oxidative stress-induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway by Zhao B1, Ren B1, Guo R1, Zhang W1, Ma S1, Yao Y1, Yuan T1, Liu Z1, Liu X. (PubMed)
Tuesday, 22 August 2023
Phytochemical #Indicaxanthin Incorporates Into the Redox Machinery of Beta-Thalassemia RBC and Defends the Cell from Oxidation Beta Thalassemia Anemia
Kyle J. Norton
Anemia is a medical condition associated with a lack of healthy red blood cells or hemoglobin in the blood.
Iron deficiency anemia is one of the most common anemia, caused by poor iron levels in the blood, leading to the reduced delivery of oxygen throughout the body.
People with a long-term deficiency of folate and vitamin B-12 which play a critical role in the production of healthy red blood cells are also at an increased risk of Amenia.
Patients with Beta-thalassemia minor have a slight lowering of the beta hemoglobin level in the blood similar to those with mild iron-deficiency anemia.
Beta thalassemia can be classified into
* Thalassemia minor, the mild case of anemia, is the most common anemia in people of Mediterranean descent. The blood cells of patients with thalassemia minor are smaller than normal blood cells and easily die off, causing not enough new blood cells to replace the red blood cell loss.
* Thalassemia major
Thalassemia major also called Cooley's anemia is an inherited disorder that affects the production of normal hemoglobin. Thalassemia major is a deadly disease without frequent blood transfusions, people with this kind of anemia may not survive because of iron building up in the heart and other organs, which can lead to heart failure.
The most common symptoms of beta-thalassemia are fatigue, weakness, or shortness of breath, a pale appearance or yellow color to the skin (jaundice), irritability, deformities of the facial bone, slow growth, a swollen abdomen, and dark urine.
There are many risk factors involved in the onset of the condition. Blood loss, such as from heavy menstrual bleeding, ulcer, cancer, and regular use of some over-the-counter pain relievers, especially aspirin are some of the most common prevalent risk factors.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an antioxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
Indicaxanthin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.
In finding a potential compound for the treatment of beta-thalassemia red blood cells, researchers examined the antioxidant activity of indicaxanthin.
In vitro, human beta-thalassemia RBCs submitted to oxidative hemolysis by cumene hydroperoxide, application of indicaxanthin at 1.0-10 microM enhanced the resistance to hemolysis associated with the destruction of red blood cells in a dose-dependent manner.
Furthermore, the phytochemical also exerted a significant antioxidant activity by preventing lipid and hemoglobin (Hb) oxidation and enhancing the levels of vitamin E and GSH depletion.
Moreover, indicaxanthin also stimulated the recovery of the soluble cell compartment of the RBCs in the blood from thalassemia patients.
According to the A spectrophotometric study, the antioxidant also showed to reduce the reactive intermediate that makes an abnormal form of hemoglobin in solution caused by the oxidative stress, compared to those of Trolox or vitamin C.
Based on the findings, researchers said, "Collectively our results demonstrate that indicaxanthin can be incorporated into the redox machinery of beta-thalassemia RBC and defend the cell from oxidation".
Taken altogether, indicaxanthin may be considered a remedy for the prevention and treatment of beta-thalassemia anemia, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells by Tesoriere L1, Allegra M, Butera D, Gentile C, Livrea MA. (PubMed)
Anemia is a medical condition associated with a lack of healthy red blood cells or hemoglobin in the blood.
Iron deficiency anemia is one of the most common anemia, caused by poor iron levels in the blood, leading to the reduced delivery of oxygen throughout the body.
People with a long-term deficiency of folate and vitamin B-12 which play a critical role in the production of healthy red blood cells are also at an increased risk of Amenia.
Patients with Beta-thalassemia minor have a slight lowering of the beta hemoglobin level in the blood similar to those with mild iron-deficiency anemia.
Beta thalassemia can be classified into
* Thalassemia minor, the mild case of anemia, is the most common anemia in people of Mediterranean descent. The blood cells of patients with thalassemia minor are smaller than normal blood cells and easily die off, causing not enough new blood cells to replace the red blood cell loss.
* Thalassemia major
Thalassemia major also called Cooley's anemia is an inherited disorder that affects the production of normal hemoglobin. Thalassemia major is a deadly disease without frequent blood transfusions, people with this kind of anemia may not survive because of iron building up in the heart and other organs, which can lead to heart failure.
The most common symptoms of beta-thalassemia are fatigue, weakness, or shortness of breath, a pale appearance or yellow color to the skin (jaundice), irritability, deformities of the facial bone, slow growth, a swollen abdomen, and dark urine.
There are many risk factors involved in the onset of the condition. Blood loss, such as from heavy menstrual bleeding, ulcer, cancer, and regular use of some over-the-counter pain relievers, especially aspirin are some of the most common prevalent risk factors.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an antioxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
Indicaxanthin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.
In finding a potential compound for the treatment of beta-thalassemia red blood cells, researchers examined the antioxidant activity of indicaxanthin.
In vitro, human beta-thalassemia RBCs submitted to oxidative hemolysis by cumene hydroperoxide, application of indicaxanthin at 1.0-10 microM enhanced the resistance to hemolysis associated with the destruction of red blood cells in a dose-dependent manner.
Furthermore, the phytochemical also exerted a significant antioxidant activity by preventing lipid and hemoglobin (Hb) oxidation and enhancing the levels of vitamin E and GSH depletion.
Moreover, indicaxanthin also stimulated the recovery of the soluble cell compartment of the RBCs in the blood from thalassemia patients.
According to the A spectrophotometric study, the antioxidant also showed to reduce the reactive intermediate that makes an abnormal form of hemoglobin in solution caused by the oxidative stress, compared to those of Trolox or vitamin C.
Based on the findings, researchers said, "Collectively our results demonstrate that indicaxanthin can be incorporated into the redox machinery of beta-thalassemia RBC and defend the cell from oxidation".
Taken altogether, indicaxanthin may be considered a remedy for the prevention and treatment of beta-thalassemia anemia, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells by Tesoriere L1, Allegra M, Butera D, Gentile C, Livrea MA. (PubMed)
#Turmeric Processes #Antiproliferative, Anti-inflammatory by Inhibiting #Angiogenic Activity, Researchers Say
Kyle J. Norton
Angiogenesis is the process that promotes the formation of new blood vessels involving many factors including the migration, growth, and differentiation of endothelial cells.
In normal cells, angiogenesis is important for the cells to obtain nutrients and metabolites through the newly forming small blood vessels. Angiogenesis has been found to process a therapeutic effect for the treatment of ischemic heart disease, peripheral arterial disease, and wound healing.
Dr. Papetti M, the lead scientist at the Tufts University School of Medicine said, "Normal angiogenesis ensures that developing or healing tissues receive an adequate supply of nutrients".
In cancers, angiogenesis stimulated by the tumor cells has been associated with tumors proliferation and metastasis".
More precisely, the angiogenesis process is a function of a double sword. On one hand, the process provides an ideal condition for the treatment of diseases and wound healing. On the other hand, it promotes invasive and overgrowth tumors.
Dr. Papetti M continued, "Tumor cells induce the formation of new blood supply from the preexisting vasculature, and this affords tumor cells the ability to survive and propagate in a hostile environment"
Collectively, " both normal and tumor-induced neovascularization fulfill the essential role of satisfying the metabolic demands of tissue".
Therefore, by inhibiting the process of blood vessel formation of the tumor, cancer may be curable.
Dr. Dai X, the lead researcher in the study of "Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis" showed, "trichosanthin TCS, ( an immunosuppressive and anti-tumor protein) inhibits murine B-cell lymphoma growth by anti-angiogenesis was reported. First, TCS inhibits tumor growth and prolonged survival significantly in vivo, and TCS depressed the formation of new blood vessels around the tumor in a dose-dependent manner".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a natural ingredient for the treatment of cancer, researchers examined the Trivalent arsenic [As(III)] induced damaging effects on human health such as angiogenesis.
Epidemiologically, Trivalent arsenic [As(III)] has been found to induce the development of cardiovascular disease, diabetes, cancer, and angiogenesis.
According to tested analysis, the administration of curcumin, an active ingredient in dietary turmeric has been shown to demonstrate potent antiproliferative, anti-inflammatory by inhibiting angiogenic activity.
In HCT-116 human colon cancer cells exposed to As(III), both curcumin and turmeric inhibit the expression of vascular endothelial growth factor associated with the promotion of the growth of new blood vessels from the existing blood vessels.
In the chicken chorioallantoic membrane assay model, curcumin or turmeric. also inhibited the extensive increase in blood vessel density.
Based on the findings, researchers wrote, " the findings reported here strongly suggest that turmeric and curcumin can dramatically attenuate the process of angiogenesis induced by low As(III) concentrations".
Taken altogether, turmeric processed with a high amount of bioactive compound curcumin may be considered a supplement for the prevention and treatment of cancer associated with angiogenesis, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo by Pantazis P1, Varman A, Simpson-Durand C, Thorpe J, Ramalingam S, Subramaniam D, Houchen C, Ihnat M, Anant S, Ramanujam RP. (PubMed)
(2) Angiogenesis in Cancer by Naoyo Nishida,1,2 Hirohisa Yano,1 Takashi Nishida,3 Toshiharu Kamura,2 andMasamichi Kojiro. (PMC)
(3) Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis by Xingbin Dai,1,2 Pengjun Jiang,2 Yanhua Ji,3 Xuejun Zhu,2 and Xuemei Sun2. (PMC)
Angiogenesis is the process that promotes the formation of new blood vessels involving many factors including the migration, growth, and differentiation of endothelial cells.
In normal cells, angiogenesis is important for the cells to obtain nutrients and metabolites through the newly forming small blood vessels. Angiogenesis has been found to process a therapeutic effect for the treatment of ischemic heart disease, peripheral arterial disease, and wound healing.
Dr. Papetti M, the lead scientist at the Tufts University School of Medicine said, "Normal angiogenesis ensures that developing or healing tissues receive an adequate supply of nutrients".
In cancers, angiogenesis stimulated by the tumor cells has been associated with tumors proliferation and metastasis".
More precisely, the angiogenesis process is a function of a double sword. On one hand, the process provides an ideal condition for the treatment of diseases and wound healing. On the other hand, it promotes invasive and overgrowth tumors.
Dr. Papetti M continued, "Tumor cells induce the formation of new blood supply from the preexisting vasculature, and this affords tumor cells the ability to survive and propagate in a hostile environment"
Collectively, " both normal and tumor-induced neovascularization fulfill the essential role of satisfying the metabolic demands of tissue".
Therefore, by inhibiting the process of blood vessel formation of the tumor, cancer may be curable.
Dr. Dai X, the lead researcher in the study of "Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis" showed, "trichosanthin TCS, ( an immunosuppressive and anti-tumor protein) inhibits murine B-cell lymphoma growth by anti-angiogenesis was reported. First, TCS inhibits tumor growth and prolonged survival significantly in vivo, and TCS depressed the formation of new blood vessels around the tumor in a dose-dependent manner".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a natural ingredient for the treatment of cancer, researchers examined the Trivalent arsenic [As(III)] induced damaging effects on human health such as angiogenesis.
Epidemiologically, Trivalent arsenic [As(III)] has been found to induce the development of cardiovascular disease, diabetes, cancer, and angiogenesis.
According to tested analysis, the administration of curcumin, an active ingredient in dietary turmeric has been shown to demonstrate potent antiproliferative, anti-inflammatory by inhibiting angiogenic activity.
In HCT-116 human colon cancer cells exposed to As(III), both curcumin and turmeric inhibit the expression of vascular endothelial growth factor associated with the promotion of the growth of new blood vessels from the existing blood vessels.
In the chicken chorioallantoic membrane assay model, curcumin or turmeric. also inhibited the extensive increase in blood vessel density.
Based on the findings, researchers wrote, " the findings reported here strongly suggest that turmeric and curcumin can dramatically attenuate the process of angiogenesis induced by low As(III) concentrations".
Taken altogether, turmeric processed with a high amount of bioactive compound curcumin may be considered a supplement for the prevention and treatment of cancer associated with angiogenesis, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin and turmeric attenuate arsenic-induced angiogenesis in ovo by Pantazis P1, Varman A, Simpson-Durand C, Thorpe J, Ramalingam S, Subramaniam D, Houchen C, Ihnat M, Anant S, Ramanujam RP. (PubMed)
(2) Angiogenesis in Cancer by Naoyo Nishida,1,2 Hirohisa Yano,1 Takashi Nishida,3 Toshiharu Kamura,2 andMasamichi Kojiro. (PMC)
(3) Suppression of murine B-cell lymphoma growth by trichosanthin through anti-angiogenesis by Xingbin Dai,1,2 Pengjun Jiang,2 Yanhua Ji,3 Xuejun Zhu,2 and Xuemei Sun2. (PMC)
#Hydrophilic or #Lipophilic #Tomato Ketchup #Extracts Inhibit Gene Expression Associated with Pro-Inflammatory Cytokines , Researchers Say
Kyle J. Norton
Inflammation is a natural response by the immune system to protect the body against the invasion of stimuli or foreign pathogens.
In other words, the white blood cells on the first line of defense of the immune system after sensing the danger of an infection in the body through a message from the brain stimulate the production of the palette to cover the site of injury or damage and inflammatory cytokines to kill off all pathogens before they can cause harm to the body.
Most cases of infection are stopped at the acute phase. The wound or injury is slowly recovered.
However, in severe cases, particularly in people with a weakened immune system, the inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, leading to low-grade chronic inflammation.
Diseases associated with low-grade inflammation include diabetes and cardiovascular.
Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.
In the US, chronic inflammatory diseases affect more than 50 million Americans each year.
Dr. Roma Pahwa in the classification of chronic inflammation wrote, "Chronic inflammation is also referred to as slow, long-term inflammation lasting for prolonged periods of several months to years. Generally, the extent and effects of chronic inflammation vary with the cause of the injury and the ability of the body to repair and overcome the damage".
And, "(The causes of chronic inflammation are) Failure of eliminating the agent causing acute inflammation, ..., Exposure to a low level of a particular irritant or foreign materials,...An autoimmune disorder,... Recurrent episodes of acute inflammation,... Inflammatory and biochemical inducers"
Tomato is red, edible fruit, genus Solanum, and belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In finding a potential compound for the treatment of inflammatory diseases researchers examined the effect of tomato ketchup extracts and bioactive from tomato ketchup on human monocytes and vascular endothelial cells (HUVEC).
HUVEC selected for the study were pre-treated for 1 h with either individual bioactive (7.5 µM lycopene, 1.4 µM α-tocopherol, or 55 µM ascorbic acid) or a combination of these three compounds, or with the hydrophilic or lipophilic tomato ketchup extracts or with the two extracts combined.
According to the tested assays, tomato ketchup extracts significantly reduced gene expression and pro-inflammatory cytokines TNF-α and IL-8 in HUVEC after inducing inflammation.
Furthermore, levels of anti-inflammatory release were increased observed by the expression of anti-inflammatory cytokine IL-10.
The effects were correlated with the reduction of IL-8 production in the presence of the test compounds and extracts.
In other words, lycopene found in tomato extract is one of the major bioactive compounds that induce the anti-inflammatory effect, and α-tocopherol and ascorbic acid appeared to strengthen the anti-inflammatory effect of lycopene.
In order to obtain more information about tomato anti-inflammatory activity, researchers analyzed the potential protective effects of phytochemicals in tomatoes on inflammation.
According to the nitric oxide (NO) assay, tomato extract exhibited an anti-inflammatory effect by inhibiting the NO production in LPS-stimulated RAW264 macrophages.
Levels of pro-inflammatory cytokines were significantly decreased after the injection of tomatoes.
The efficacy of tomatoes was attributed to the bioactive compound RF52 in the inhibition of the production of these proinflammatory mediators.
Dr. Kim YI, the lead scientist said, "These results suggest that RF52 from tomatoes may have the potential to suppress inflammation by inhibiting the production of NO or proinflammatory cytokines during the interaction between adipocytes and macrophages".
Taken together, tomatoes may be considered functional food for the prevention and treatment of inflammatory diseases, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protection against chemotaxis in the anti-inflammatory effect of bioactive from tomato ketchup by Hazewindus M1, Haenen GR1, Weseler AR1, Bast A. (PubMed)
(2) Tomato extract suppresses the production of proinflammatory mediators induced by the interaction between adipocytes and macrophages by Kim YI1, Mohri S, Hirai S, Lin S, Goto T, Ohyane C, Sakamoto T, Takahashi H, Shibata D, Takahashi N, Kawada T. (PubMed)
(3) Chronic Inflammation by Roma Pahwa; Ishwarlal Jialal. (NCBI)
Inflammation is a natural response by the immune system to protect the body against the invasion of stimuli or foreign pathogens.
In other words, the white blood cells on the first line of defense of the immune system after sensing the danger of an infection in the body through a message from the brain stimulate the production of the palette to cover the site of injury or damage and inflammatory cytokines to kill off all pathogens before they can cause harm to the body.
Most cases of infection are stopped at the acute phase. The wound or injury is slowly recovered.
However, in severe cases, particularly in people with a weakened immune system, the inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, leading to low-grade chronic inflammation.
Diseases associated with low-grade inflammation include diabetes and cardiovascular.
Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.
In the US, chronic inflammatory diseases affect more than 50 million Americans each year.
Dr. Roma Pahwa in the classification of chronic inflammation wrote, "Chronic inflammation is also referred to as slow, long-term inflammation lasting for prolonged periods of several months to years. Generally, the extent and effects of chronic inflammation vary with the cause of the injury and the ability of the body to repair and overcome the damage".
And, "(The causes of chronic inflammation are) Failure of eliminating the agent causing acute inflammation, ..., Exposure to a low level of a particular irritant or foreign materials,...An autoimmune disorder,... Recurrent episodes of acute inflammation,... Inflammatory and biochemical inducers"
Tomato is red, edible fruit, genus Solanum, and belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In finding a potential compound for the treatment of inflammatory diseases researchers examined the effect of tomato ketchup extracts and bioactive from tomato ketchup on human monocytes and vascular endothelial cells (HUVEC).
HUVEC selected for the study were pre-treated for 1 h with either individual bioactive (7.5 µM lycopene, 1.4 µM α-tocopherol, or 55 µM ascorbic acid) or a combination of these three compounds, or with the hydrophilic or lipophilic tomato ketchup extracts or with the two extracts combined.
According to the tested assays, tomato ketchup extracts significantly reduced gene expression and pro-inflammatory cytokines TNF-α and IL-8 in HUVEC after inducing inflammation.
Furthermore, levels of anti-inflammatory release were increased observed by the expression of anti-inflammatory cytokine IL-10.
The effects were correlated with the reduction of IL-8 production in the presence of the test compounds and extracts.
In other words, lycopene found in tomato extract is one of the major bioactive compounds that induce the anti-inflammatory effect, and α-tocopherol and ascorbic acid appeared to strengthen the anti-inflammatory effect of lycopene.
In order to obtain more information about tomato anti-inflammatory activity, researchers analyzed the potential protective effects of phytochemicals in tomatoes on inflammation.
According to the nitric oxide (NO) assay, tomato extract exhibited an anti-inflammatory effect by inhibiting the NO production in LPS-stimulated RAW264 macrophages.
Levels of pro-inflammatory cytokines were significantly decreased after the injection of tomatoes.
The efficacy of tomatoes was attributed to the bioactive compound RF52 in the inhibition of the production of these proinflammatory mediators.
Dr. Kim YI, the lead scientist said, "These results suggest that RF52 from tomatoes may have the potential to suppress inflammation by inhibiting the production of NO or proinflammatory cytokines during the interaction between adipocytes and macrophages".
Taken together, tomatoes may be considered functional food for the prevention and treatment of inflammatory diseases, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protection against chemotaxis in the anti-inflammatory effect of bioactive from tomato ketchup by Hazewindus M1, Haenen GR1, Weseler AR1, Bast A. (PubMed)
(2) Tomato extract suppresses the production of proinflammatory mediators induced by the interaction between adipocytes and macrophages by Kim YI1, Mohri S, Hirai S, Lin S, Goto T, Ohyane C, Sakamoto T, Takahashi H, Shibata D, Takahashi N, Kawada T. (PubMed)
(3) Chronic Inflammation by Roma Pahwa; Ishwarlal Jialal. (NCBI)
Foods and Herbs That Process Anti High Blood Pressure Activity with No Side Effects, Scientists Say
Kyle J. Norton
In seeking natural therapy with no side effects, scientists may have a herbal remedy for normalizing blood pressure, according to studies.
Hypertension is a chronic condition caused by abnormally high blood pressure.
High blood pressure is a condition of a cluster of metabolic syndrome associated with the increased risk of heart disease and stroke.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
In high blood pressure individuals, due to the elevated blood pressure in your arteries, the heart has to work harder than normal to pump blood through the blood vessels.
In low blood pressure individuals, the reduced blood pressure in the arteries drops can cause the heart to pump blood at a slower rate than normal.
According to the standard guidelines, the levels of blood pressure are normal if it is more than 120 over 80 and less than 140 over 90 (120/80-140/90).
People with blood pressure lower than 120/80 are considered normal without being accompanied by symptoms of light-head or dizziness.
According to the statistics provided by the CDC, in the U.S. 29% or 100 million adults have hypertension during 2015–2016 and hypertension prevalence increased with age and was 33.2% among those aged 40–59 and 63.1% among those aged 60 and over.
Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.
The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener.
Researchers in the course of finding a natural ingredient for the treatment of high blood pressure investigated the safety and effect of intrapulmonary administration (by inhalation) of 60 % honey solution, 10% dextrose, or distilled water in normal or diabetic subjects.
Twenty-four healthy subjects, 16 patients with type 1 diabetes mellitus and six patients with hypertension were selected to participate in the study.
Twelve healthy subjects were subjected to distilling water inhalation for 10 min, and after one week they received inhalation of honey solution (60% wt/v) for 10 min. Another 12 healthy subjects received inhalation of 10% dextrose for 10 min.
Honey treatment showed a mild reduction of blood pressure compared to no change in another group.
From a time perspective, systolic and diastolic blood pressure was reduced by honey inhalation in hypertensive patients at 60 and 120 min.
After taking into account co and confounders, researchers said, "Honey inhalation was safe and effective in reducing...elevated blood pressure in hypertensive patients".
Moreover, in order to obtain more information on honey antihypertensive activity, researchers investigated the aqueous extract obtained from the mixture of the fresh leaf of Persea Americana, stems, and a fresh leaf of Cymbopogon citrus, fruits of Citrus medica, and honey on ethanol and sucrose-induced hypertension in rats.
Rats included in the study were divided into eight groups of 6 rats each and daily treated for 5 weeks. The control group received distilled water (1 mL/kg) while rats of groups 2, 3, and 4 received ethanol 40 degrees (3 g/kg/day), 10% sucrose as drinking water, and the two substances respectively.
The remaining groups received additional sucrose and ethanol, the aqueous extract (50, 100, and 150 mg/kg) and nifedipine (10 mg/kg) respectively.
The group treated with ethanol and sucrose showed a significantly (p < 0.001) increased blood pressure and heart rate compared to distilled water-treated rats.
Chronic treatment of ethanol and sucrose also exerted significantly decreased the activities of antioxidant enzymes produced by the host, observed by the levels of superoxide dismutase (SOD) and catalase (CAT) and elevated levels of oxidative stress observed by the stress marker malondialdehyde (MDA) levels.
However, administration of the aqueous extract or nifedipine prevented all changes caused by chronic ethanol and sucrose, including hemodynamic, biochemical, oxidative, and histological impairments.
The finding clearly suggested that aqueous extract including honey possesses antihypertensive activity by the improvement of biochemical and oxidative status, through its antioxidant property.
Taken together, honey used alone or combined with other herbs may be considered anti-hypertension functional remedies with no side effects, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Intrapulmonary administration of the natural honey solution, hyperosmolar dextrose, or hypoosmolar distill water to normal individuals and to patients with type-2 diabetes mellitus or hypertension: their effects on blood glucose level, plasma insulin, and C-peptide, blood pressure and peaked expiratory flow rate by Al-Waili N1. (PubMed)
(2) Antihypertensive potential of the aqueous extract which combines the leaf of Persea americana Mill. (Lauraceae), stems and leaf of Cymbopogon citratus (D.C) Stapf. (Poaceae), fruits of Citrus medical L. (Rutaceae) as well as honey in ethanol and sucrose experimental model by Dzeufiet PD1, Mogueo A, Bilanda DC, Aboubakar BF, Tédong L, Dimo T, Kamtchouing P. (PubMed)
In seeking natural therapy with no side effects, scientists may have a herbal remedy for normalizing blood pressure, according to studies.
Hypertension is a chronic condition caused by abnormally high blood pressure.
High blood pressure is a condition of a cluster of metabolic syndrome associated with the increased risk of heart disease and stroke.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
In high blood pressure individuals, due to the elevated blood pressure in your arteries, the heart has to work harder than normal to pump blood through the blood vessels.
In low blood pressure individuals, the reduced blood pressure in the arteries drops can cause the heart to pump blood at a slower rate than normal.
According to the standard guidelines, the levels of blood pressure are normal if it is more than 120 over 80 and less than 140 over 90 (120/80-140/90).
People with blood pressure lower than 120/80 are considered normal without being accompanied by symptoms of light-head or dizziness.
According to the statistics provided by the CDC, in the U.S. 29% or 100 million adults have hypertension during 2015–2016 and hypertension prevalence increased with age and was 33.2% among those aged 40–59 and 63.1% among those aged 60 and over.
Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.
The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener.
Researchers in the course of finding a natural ingredient for the treatment of high blood pressure investigated the safety and effect of intrapulmonary administration (by inhalation) of 60 % honey solution, 10% dextrose, or distilled water in normal or diabetic subjects.
Twenty-four healthy subjects, 16 patients with type 1 diabetes mellitus and six patients with hypertension were selected to participate in the study.
Twelve healthy subjects were subjected to distilling water inhalation for 10 min, and after one week they received inhalation of honey solution (60% wt/v) for 10 min. Another 12 healthy subjects received inhalation of 10% dextrose for 10 min.
Honey treatment showed a mild reduction of blood pressure compared to no change in another group.
From a time perspective, systolic and diastolic blood pressure was reduced by honey inhalation in hypertensive patients at 60 and 120 min.
After taking into account co and confounders, researchers said, "Honey inhalation was safe and effective in reducing...elevated blood pressure in hypertensive patients".
Moreover, in order to obtain more information on honey antihypertensive activity, researchers investigated the aqueous extract obtained from the mixture of the fresh leaf of Persea Americana, stems, and a fresh leaf of Cymbopogon citrus, fruits of Citrus medica, and honey on ethanol and sucrose-induced hypertension in rats.
Rats included in the study were divided into eight groups of 6 rats each and daily treated for 5 weeks. The control group received distilled water (1 mL/kg) while rats of groups 2, 3, and 4 received ethanol 40 degrees (3 g/kg/day), 10% sucrose as drinking water, and the two substances respectively.
The remaining groups received additional sucrose and ethanol, the aqueous extract (50, 100, and 150 mg/kg) and nifedipine (10 mg/kg) respectively.
The group treated with ethanol and sucrose showed a significantly (p < 0.001) increased blood pressure and heart rate compared to distilled water-treated rats.
Chronic treatment of ethanol and sucrose also exerted significantly decreased the activities of antioxidant enzymes produced by the host, observed by the levels of superoxide dismutase (SOD) and catalase (CAT) and elevated levels of oxidative stress observed by the stress marker malondialdehyde (MDA) levels.
However, administration of the aqueous extract or nifedipine prevented all changes caused by chronic ethanol and sucrose, including hemodynamic, biochemical, oxidative, and histological impairments.
The finding clearly suggested that aqueous extract including honey possesses antihypertensive activity by the improvement of biochemical and oxidative status, through its antioxidant property.
Taken together, honey used alone or combined with other herbs may be considered anti-hypertension functional remedies with no side effects, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Intrapulmonary administration of the natural honey solution, hyperosmolar dextrose, or hypoosmolar distill water to normal individuals and to patients with type-2 diabetes mellitus or hypertension: their effects on blood glucose level, plasma insulin, and C-peptide, blood pressure and peaked expiratory flow rate by Al-Waili N1. (PubMed)
(2) Antihypertensive potential of the aqueous extract which combines the leaf of Persea americana Mill. (Lauraceae), stems and leaf of Cymbopogon citratus (D.C) Stapf. (Poaceae), fruits of Citrus medical L. (Rutaceae) as well as honey in ethanol and sucrose experimental model by Dzeufiet PD1, Mogueo A, Bilanda DC, Aboubakar BF, Tédong L, Dimo T, Kamtchouing P. (PubMed)
Monday, 21 August 2023
Xiao Wei Yan Powder (XWYP) Decoction Processes Anti-Intestinal Metaplasia (IM) and Atypical Hyperplasia (AH) Property, Researchers Say
Kyle J. Norton
The stomach located between the esophagus and the small intestine is a muscular, hollow, and important organ of the digestive tract.
The stomach plays a critical role in aiding the digestive system by secreting acid and enzymes that digest food induced by the stomach muscles that contract periodically, to churn the food and enhance digestion.
Atypical hyperplasia is a precancerous condition characterized by the accumulation of abnormal cells.
Intestinal metaplasia is a pre gastric cancer condition caused by the change of cells in the stomach.
The exact causes of the condition are unknown. However, some researchers suggested that smoking and infection caused by H. pylori infection, genetic preposition, and environmental factors are some risk factors associated with the onset of intestinal metaplasia.
Gastric cancer is a medical condition characterized by irregular and uncontrollable cell growth in the stomach lining in the beginning. At the advanced stage, the malignant cells can travel a distance away through blood and fluid circulation to infect other healthy tissue and organs.
Researchers do not know why some people with the same health condition are susceptible to the risk of gastric cancer, while others do not. The exact causes of gastric cancer are also unknown. However, some researchers suggested that Age, diet, and stomach disease, such as can increase the risk of developing gastric cancer.
Both atrophic gastritis and gastric cancer share the common symptoms of stomach pain, nausea and vomiting, loss of appetite,... and indigestion. However, common symptoms of unexpected weight loss and stomach ulcers can only be found in gastric cancer while iron deficiency anemia is found in the majority of patients with atrophic gastritis.
According to the statistics provided by the American Cancer Society, in 2019, approximately, 27,510 cases of stomach cancer will be diagnosed (17,230 in men and 10,280 in women) and 11,140 people will die from gastric cancer (6,800 men and 4,340 women).
Overall, the 5-year survival rate for people with gastric cancer is 31%. Cancer diagnosed at the localized stage have a 5 years survival rate of 67%.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of gastric diseases, scientists examined the efficacy of Xiao Wei Yan Powder (XWYP) decoction on intestinal metaplasia (IM) and 104 cases of atypical hyperplasia (AH).
Where XWYP is a traditional Chinese Medicine formula containing Smilax glabrate, Hedyotis diffusae, Taraxacum mongolicum, Caesalpinia sappan, Paeonia alba, Cyperus rotundus, Bletilla striata, Glycyrrhiza uralensis, etc.
According to the results of 138 cases of intestinal metaplasia (IM) and 104 cases of atypical hyperplasia (AH) of the gastric mucosa of chronic gastritis that was treated by Xiao Wei Yan Powder (XWYP) orally 5-7g, for a period from 2-4 months, compared to control, the decoction showed a significant effect rate of IM was 91.3% and that of the AH was 92.16% compared to the control group of 21.3% and 14.46% respectively.
More precisely, XWYP not only had marked therapeutic effects for IM and AH but also showed no toxic effects in the animal experiments revealed no toxic effect,
These results strongly suggested that a safety guarantee was provided for its clinical application.
Taken altogether, Dandelion in combination with other Chinese medicines may be considered a remedy for the treatment of intestinal metaplasia and atypical hyperplasia (AH), pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Treatment of intestinal metaplasia and atypical hyperplasia of gastric mucosa with xiao Wei yan powder].[Article in Chinese] by Liu XR1, Han WQ, Sun DR. (PubMed)
The stomach located between the esophagus and the small intestine is a muscular, hollow, and important organ of the digestive tract.
The stomach plays a critical role in aiding the digestive system by secreting acid and enzymes that digest food induced by the stomach muscles that contract periodically, to churn the food and enhance digestion.
Atypical hyperplasia is a precancerous condition characterized by the accumulation of abnormal cells.
Intestinal metaplasia is a pre gastric cancer condition caused by the change of cells in the stomach.
The exact causes of the condition are unknown. However, some researchers suggested that smoking and infection caused by H. pylori infection, genetic preposition, and environmental factors are some risk factors associated with the onset of intestinal metaplasia.
Gastric cancer is a medical condition characterized by irregular and uncontrollable cell growth in the stomach lining in the beginning. At the advanced stage, the malignant cells can travel a distance away through blood and fluid circulation to infect other healthy tissue and organs.
Researchers do not know why some people with the same health condition are susceptible to the risk of gastric cancer, while others do not. The exact causes of gastric cancer are also unknown. However, some researchers suggested that Age, diet, and stomach disease, such as can increase the risk of developing gastric cancer.
Both atrophic gastritis and gastric cancer share the common symptoms of stomach pain, nausea and vomiting, loss of appetite,... and indigestion. However, common symptoms of unexpected weight loss and stomach ulcers can only be found in gastric cancer while iron deficiency anemia is found in the majority of patients with atrophic gastritis.
According to the statistics provided by the American Cancer Society, in 2019, approximately, 27,510 cases of stomach cancer will be diagnosed (17,230 in men and 10,280 in women) and 11,140 people will die from gastric cancer (6,800 men and 4,340 women).
Overall, the 5-year survival rate for people with gastric cancer is 31%. Cancer diagnosed at the localized stage have a 5 years survival rate of 67%.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the prevention and treatment of gastric diseases, scientists examined the efficacy of Xiao Wei Yan Powder (XWYP) decoction on intestinal metaplasia (IM) and 104 cases of atypical hyperplasia (AH).
Where XWYP is a traditional Chinese Medicine formula containing Smilax glabrate, Hedyotis diffusae, Taraxacum mongolicum, Caesalpinia sappan, Paeonia alba, Cyperus rotundus, Bletilla striata, Glycyrrhiza uralensis, etc.
According to the results of 138 cases of intestinal metaplasia (IM) and 104 cases of atypical hyperplasia (AH) of the gastric mucosa of chronic gastritis that was treated by Xiao Wei Yan Powder (XWYP) orally 5-7g, for a period from 2-4 months, compared to control, the decoction showed a significant effect rate of IM was 91.3% and that of the AH was 92.16% compared to the control group of 21.3% and 14.46% respectively.
More precisely, XWYP not only had marked therapeutic effects for IM and AH but also showed no toxic effects in the animal experiments revealed no toxic effect,
These results strongly suggested that a safety guarantee was provided for its clinical application.
Taken altogether, Dandelion in combination with other Chinese medicines may be considered a remedy for the treatment of intestinal metaplasia and atypical hyperplasia (AH), pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Treatment of intestinal metaplasia and atypical hyperplasia of gastric mucosa with xiao Wei yan powder].[Article in Chinese] by Liu XR1, Han WQ, Sun DR. (PubMed)
Smoothie of Cherries, Ginger and Peppermint Inhibit Diseases Associated with Symptoms of #Chronic and Acute Pain, Scientists Show
Kyle J. Norton
The finding of a natural source for the treatment of Autosomal recessive polycystic kidney disease has been running into many obstacles, many ingredients shown initially with promising results in animal studies have not produced the same potential in large sample sizes and multi centers human trials.
Autosomal recessive polycystic kidney disease is an inherited disease (Mutations in the PKHD1)causing abnormal functions of the liver and reno-inducing morbidity and mortality in children.
Until today, there is no cure, or treatment options for autosomal recessive polycystic kidney disease, depending on complications, such as chronic pain.
The smoothie for people with chronic pain in Autosomal recessive polycystic kidney disease
Yield: 2 servings (about 8 ounces each)
1 1/2 cups cherries cups pineapple
1 slice of ginger root
1 cup of peppermint herbal tea
1. Place all ingredients in a blender and puree for about 1 minute
2. Blend on high speed for about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drinks if needed
3. Serve immediately
Cherries(1), ginger(4), and peppermint(7) may be the next combination of therapeutic ingredients as a pain reliever for the treatment of chronic pain in patients with autosomal recessive polycystic kidney disease.
Cherry, a fleshy drupe, is the fruit of many plants of the genus Prunus cultivated all over the world for commercial profit due to its health potential.
In a randomized double-blind crossover study of 58 non-diabetic patients, oral administration of cherry juice improved the Western Ontario McMaster Osteoarthritis Index (WOMAC) scores, inducing symptom relief, including pain for patients with mild to moderate knee Osteoarthritis, through lowering the C-reactive protein CRP levels(1). According to the Oregon Health & Science University, the study of fifty-four healthy runners with ingesting 355 mL bottles of tart cherry juice twice daily for 7 days, during a strenuous running event can minimize post-run muscle pain(3).
Dr. Kuehl KS said, "Tart cherries appear to possess similar effectiveness in treating the inflammatory reaction seen in both acute and chronic pain syndromes encountered among athletes and non-athletes with chronic inflammatory disease")2) they may be used as an antioxidant and anti-inflammatory ingredient on prevention, treatment, and recovery of soft tissue injury and pain.
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil, used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In primary dysmenorrhea patients, ginger is effective in pain relief without inducing adverse effects and may be used as an alternative treatment for primary dysmenorrhea, according to the Mazandaran University of Medical Sciences(4) and treatment of ginger in students with primary dysmenorrhea for 5 days also showed a statistically significant effect on relieving intensity and duration of pain, the Shahid University, the study suggested(5).
Furthermore, in osteoarthritic patients, Dr. Therkleson T said," Ginger therapy activated a marked relief of osteoarthritis symptoms that progressively improved over the 24 weeks, with no negative effects reported. Ginger therapy needs to be considered by nurses caring for specific personality types with osteoarthritis"(6).
Peppermint is a hybrid mint with small purple or white flowers and downy leaves, in the genus Mentha, belonging to the family Lamiaceae, native to Europe. The herb has been used in folk medicine as an analgesic, antiseptic, antispasmodic, decongestant, and agent and to relieve gas, nausea, and stomach pain due to irritable bowel, intestinal cramps, indigestion, infection, etc
According to the Translational Research Center for Gastrointestinal Disorders (TARGID), peppermint oil, with antispasmodics may be considered the first-line treatment for abdominal pain in patients with irritable bowel syndrome (IBS)(7).
Menthol, the cooling natural product of peppermint, according to the study conducted by Yale University School of Medicine, is widely used for the relief of acute and inflammatory pain in sports injuries, arthritis, and other painful conditions, through activating the methol-induced sensation of cooling(8).
Dr. Shen YH and Dr. Nahas R. said," Peppermint oil alleviates IBS symptoms, including abdominal pain" and "several complementary and alternative therapies can be recommended as part of an evidence-based approach to the treatment of IBS; these might provide patients with satisfactory relief and improve the therapeutic alliance"(9).
In the 76-year-old woman whose pain had been resistant to standard therapies, the application of neat peppermint oil showed to immediately improve her pain with persistence for 4-6 hours after application of the oil(10).
Taken together, People with Chronic Pain due to autosomal recessive polycystic kidney disease should drink the smoothie as much as they can, depending on digestive and liver toleration.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
References
(1) Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee by Schumacher HR1, Pullman-Mooar S, Gupta SR, Dinnella JE, Kim R, McHugh MP.(PubMed)
(2) Cherry juice targets antioxidant potential and pain relief by Kuehl KS1.(PubMed)
(3) Efficacy of tart cherry juice in reducing muscle pain during running: a randomized controlled trial by Kuehl KS1, Perrier ET, Elliot DL, Chesnutt JC. (PubMed)
(4) The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: a randomized clinical trial by Shirvani MA1, Motahari-Tabari N, Alipour A.(PubMed)
(5) Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial by Rahnama P1, Montazeri A, Huseini HF, Kianbakht S, Naseri M.(PubMed)
(6) Ginger Therapy for Osteoarthritis: A Typical Case by Therkleson T1. (PubMed)
(7) Treatment of abdominal pain in irritable bowel syndrome by Vanuytsel T1, Tack JF, Boeckxstaens GE.(PubMed)
(8) TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain by Liu B1, Fan L, Balakrishna S, Sui A, Morris JB, Jordt SE.(PubMed)
(9) Complementary and alternative medicine for treatment of irritable bowel syndrome by Shen YH1, Nahas R.(PubMed)
(10) A novel treatment of postherpetic neuralgia using peppermint oil by Davies SJ1, Harding LM, Baranowski AP.(PubMed)
The finding of a natural source for the treatment of Autosomal recessive polycystic kidney disease has been running into many obstacles, many ingredients shown initially with promising results in animal studies have not produced the same potential in large sample sizes and multi centers human trials.
Autosomal recessive polycystic kidney disease is an inherited disease (Mutations in the PKHD1)causing abnormal functions of the liver and reno-inducing morbidity and mortality in children.
Until today, there is no cure, or treatment options for autosomal recessive polycystic kidney disease, depending on complications, such as chronic pain.
The smoothie for people with chronic pain in Autosomal recessive polycystic kidney disease
Yield: 2 servings (about 8 ounces each)
1 1/2 cups cherries cups pineapple
1 slice of ginger root
1 cup of peppermint herbal tea
1. Place all ingredients in a blender and puree for about 1 minute
2. Blend on high speed for about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drinks if needed
3. Serve immediately
Cherries(1), ginger(4), and peppermint(7) may be the next combination of therapeutic ingredients as a pain reliever for the treatment of chronic pain in patients with autosomal recessive polycystic kidney disease.
Cherry, a fleshy drupe, is the fruit of many plants of the genus Prunus cultivated all over the world for commercial profit due to its health potential.
In a randomized double-blind crossover study of 58 non-diabetic patients, oral administration of cherry juice improved the Western Ontario McMaster Osteoarthritis Index (WOMAC) scores, inducing symptom relief, including pain for patients with mild to moderate knee Osteoarthritis, through lowering the C-reactive protein CRP levels(1). According to the Oregon Health & Science University, the study of fifty-four healthy runners with ingesting 355 mL bottles of tart cherry juice twice daily for 7 days, during a strenuous running event can minimize post-run muscle pain(3).
Dr. Kuehl KS said, "Tart cherries appear to possess similar effectiveness in treating the inflammatory reaction seen in both acute and chronic pain syndromes encountered among athletes and non-athletes with chronic inflammatory disease")2) they may be used as an antioxidant and anti-inflammatory ingredient on prevention, treatment, and recovery of soft tissue injury and pain.
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil, used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In primary dysmenorrhea patients, ginger is effective in pain relief without inducing adverse effects and may be used as an alternative treatment for primary dysmenorrhea, according to the Mazandaran University of Medical Sciences(4) and treatment of ginger in students with primary dysmenorrhea for 5 days also showed a statistically significant effect on relieving intensity and duration of pain, the Shahid University, the study suggested(5).
Furthermore, in osteoarthritic patients, Dr. Therkleson T said," Ginger therapy activated a marked relief of osteoarthritis symptoms that progressively improved over the 24 weeks, with no negative effects reported. Ginger therapy needs to be considered by nurses caring for specific personality types with osteoarthritis"(6).
Peppermint is a hybrid mint with small purple or white flowers and downy leaves, in the genus Mentha, belonging to the family Lamiaceae, native to Europe. The herb has been used in folk medicine as an analgesic, antiseptic, antispasmodic, decongestant, and agent and to relieve gas, nausea, and stomach pain due to irritable bowel, intestinal cramps, indigestion, infection, etc
According to the Translational Research Center for Gastrointestinal Disorders (TARGID), peppermint oil, with antispasmodics may be considered the first-line treatment for abdominal pain in patients with irritable bowel syndrome (IBS)(7).
Menthol, the cooling natural product of peppermint, according to the study conducted by Yale University School of Medicine, is widely used for the relief of acute and inflammatory pain in sports injuries, arthritis, and other painful conditions, through activating the methol-induced sensation of cooling(8).
Dr. Shen YH and Dr. Nahas R. said," Peppermint oil alleviates IBS symptoms, including abdominal pain" and "several complementary and alternative therapies can be recommended as part of an evidence-based approach to the treatment of IBS; these might provide patients with satisfactory relief and improve the therapeutic alliance"(9).
In the 76-year-old woman whose pain had been resistant to standard therapies, the application of neat peppermint oil showed to immediately improve her pain with persistence for 4-6 hours after application of the oil(10).
Taken together, People with Chronic Pain due to autosomal recessive polycystic kidney disease should drink the smoothie as much as they can, depending on digestive and liver toleration.
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Kyle J. Norton, all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
References
(1) Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee by Schumacher HR1, Pullman-Mooar S, Gupta SR, Dinnella JE, Kim R, McHugh MP.(PubMed)
(2) Cherry juice targets antioxidant potential and pain relief by Kuehl KS1.(PubMed)
(3) Efficacy of tart cherry juice in reducing muscle pain during running: a randomized controlled trial by Kuehl KS1, Perrier ET, Elliot DL, Chesnutt JC. (PubMed)
(4) The effect of mefenamic acid and ginger on pain relief in primary dysmenorrhea: a randomized clinical trial by Shirvani MA1, Motahari-Tabari N, Alipour A.(PubMed)
(5) Effect of Zingiber officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: a placebo randomized trial by Rahnama P1, Montazeri A, Huseini HF, Kianbakht S, Naseri M.(PubMed)
(6) Ginger Therapy for Osteoarthritis: A Typical Case by Therkleson T1. (PubMed)
(7) Treatment of abdominal pain in irritable bowel syndrome by Vanuytsel T1, Tack JF, Boeckxstaens GE.(PubMed)
(8) TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain by Liu B1, Fan L, Balakrishna S, Sui A, Morris JB, Jordt SE.(PubMed)
(9) Complementary and alternative medicine for treatment of irritable bowel syndrome by Shen YH1, Nahas R.(PubMed)
(10) A novel treatment of postherpetic neuralgia using peppermint oil by Davies SJ1, Harding LM, Baranowski AP.(PubMed)
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