#PolyherbalPpreparation From #Ashwagandha Exhibits Immunomodulatory Effects Against HIV Infection, Researchers Say

Kyle J. Norton

Human immunodeficiency virus -1 (HIV-1) is one of 2 types of HIV precipitated by acquired immunodeficiency syndrome (AIDS), transmitted through direct contact with HIV-infected body fluids, including blood, semen, and genital secretions,...

Human immunodeficiency virus HIV-1 is the most widespread type worldwide that can lead to acquired immunodeficiency syndrome (AIDS).

Acquired immunodeficiency syndrome (AIDS) is a chronic condition caused by the infection of the human immunodeficiency virus (HIV).

According to statistics, AIDS is the fifth leading cause of death in the US.

People between the ages of 25 and 44 in the United States are at substantially higher risk compared to other age groups.

Approximately 36.7 million people worldwide lived with HIV/AIDS in 2016, including, 2.1 million children less than 15 years of age.

According to epidemiological studies, people who serval sexual partners are the most at risk of HIV infection.

However, the virus can also transmit through infected blood transfusion, from infected mothers to children.

Most people infected by the HIV virus may experience symptoms of fever, muscle aches, and joint pain similar to those of influenza in the early stage of the viral attacks.

According to epidemiological studies, people who have serval sexual partners are the most at risk of HIV infection.

However, the virus can also transmit through infected blood transfusion, from infected mothers to children.

If untreated, the virus will slowly multiply and destroy the cells of the immune system, leading to chronic signs and symptoms of fever, fatigue, and swollen lymph nodes,...

If an infected individual has the numbers of T-cell count below 200, the person is considered to have AIDs.

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In the urgency to discover a natural ingredient for the prevention of infectious diseases, researchers examined the clinical efficacy and safety of a new polyherbal preparation, Immu-25, in HIV-infected patients.

The open-label pilot study. included 36 patients (10 female, 26 male) with a mean age of 35 +/-10 years, with confirmed HIV infection with a CD4 count <500 cells/microL, and received two capsules of the test drug twice daily for 18 months.

According to the results of the study, the polyherbal preparation produced good symptomatic improvement within 6 months with an increase in mean (95% CI) weight from 58 (53-64)kg to 63 (56-69)kg, 64 (58-72)kg and 68 (62-74)kg after 6, 12 and 18 months of treatment, respectively.

The application decreased the incidence and severity of symptoms such as diarrhea, fatigue, anorexia, cough, and fever in the participants.

Furthermore, there was a decrease in the mean (95% CI) viral load from 326 438 (428 600-186 420) copies/mL to 180 495 (258 300-124 000) copies/mL and 22 069 (42 100-16 000) copies/mL after 6 and 12 months of treatment, respectively.


Most importantly, the decrease in viral load was associated with an increase in mean (95% CI) CD4 count from a baseline of 243 (203-388) cells/microL to 336 (263-486) cells/microL after 6 months of therapy, and this continued to rise to 527 (285-767) cells/microL (p < 0.001) and 618 (362-1012) cells/microL (p < 0.001) after 12 and 18 months of treatment, respectively.


However, mild gastrointestinal adverse effects had been reported by some of the participants.


Based on the evidence, researchers said, "herbal drug may have a good immunomodulatory effect and has potential as a co-therapeutic agent in the management of HIV infection. Further studies are warranted to confirm its therapeutic potential".

Taken altogether, Ashwagandha may be considered a supplement for the prevention and treatment of HIV infection, pending the confirmation of the larger sample size and multicenter human study.


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Ovarian Cysts And PCOS Elimination
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of the antiretroviral activity of a new polyherbal drug (Immu-25) in patients with HIV infection by Usha PR1, Naidu MU, Raju YS. (PubMed)

#Phytochemical #Alliin Inhibits #Cardiotoxicity through Its Antixodaint Activity, Scientists Show

Kyle J. Norton

Cardiotoxicity is a condition caused by toxins accumulated in the heart that leads to damage to the heart muscle.
Cardiotoxicity reduced the heart's pumping blood capability, leading to a decrease in oxygen-rich blood to nourish the body tissues and organs.

The most common symptoms of cardiotoxicity, are tiredness fatigue, chronic cough, water retention and shortness of breath.

If you have experienced some of the aforementioned symptoms that can be healed within a week or 2, please check with your doctor to rule out the possibility.

The most common causes of cardiotoxicity are associated with patients receiving chemotherapy and intake of certain medications. However, infection, excessive alcohol consumption, medical conditions such as diabetes and thyroid disease, high blood pressure, and thiamine and Vitamin B deficiency have also been found to induce cardiotoxicity.

Some researchers suggested that the promotion of a high-fat diet over the past few decades that facilitate widespread obesity may increase the cardiotoxicity risk of obese who are treated by chemotherapy.

Dr. Mitra MS, the lead scientist said, "Often, chemotherapy by doxorubicin (Adriamycin) is limited due to life-threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity".

And, "HFD-induced obese rats are highly sensitized to doxorubicin-induced cardiotoxicity".

In other words, non-obese patients who follow the recommended diet before taking chemotherapy are for the treatment of cancer are less sensitive to doxorubicin-induced cardiotoxicity compared to a high-fat diet obese.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a potential compound with cardioprotective activity, researchers examined the effect of S-allyl cysteine sulphoxide (SACS) in isoproterenol (ISO)-induced cardiotoxicity in male Wistar rats.

The study included myocardial infarction induced by subcutaneous injection of ISO (150 mg/kg) once a day for 2 days followed by SACS (40 and 80 mg/kg) as pretreatment orally daily for a period of 35 days using an intragastric tube.

SACS pretreatment showed significantly lowered levels of free radicals and increased antioxidant activities of mitochondrial superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), and glutathione (GSH).

Furthermore, SACS pretreatment not only decreased the levels of mitochondrial cholesterol, free fatty acids (FFAs), triglycerides (TGs), and calcium, associated with plaque accumulation and the activity of xanthine oxidase (XOD) involved the production of the free radicals in the heart, but also increased significantly the levels of mitochondrial phospholipids of the inner membrane of the heart against damage.

Moreover, pretreatment of SACS also protected the heart mitochondrial fraction by increasing the activities of isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), alpha-ketoglutarate dehydrogenase (alpha-KGDH), NADH-dehydrogenase, and cytochrome C-oxidase.

Interestingly, oral administration of SACS for a period of 35 days showed no cardio effect in normal control rats.

In other words, SACS modulated heart function against mitochondrial cardiotoxicity without affecting the heart function in healthy control.

Based on the findings researchers said, "The effect at a dose of SACS 80 mg/kg was more effective than the dose 40 mg/kg. The results of the study conclude that SACS protects the mitochondria of the ISO-induced myocardial-infarcted rats".

In order to know more information about SACS cardioprotective activity, researchers examined the preventive role of SACS on glycoproteins and hematology in experimentally induced myocardial infarction in rats for 2 days.

Injection of SACS restored the abnormally significant increase in the levels of serum iron, uric acid and blood glucose, Na(+) and Ca(2+) characterized by heart damage and elevated blood glucose.

Furthermore, the significant decrease in the levels of plasma iron binding capacity, serum total protein, albumin/globulin ratio, heart K(+), and heart glycogen induced by isoproterenol (ISO) associated with heart tissues damage were also inhibited by the treatment of SACS in myocardial infarcted rats.

Moreover, SACS also modulated the immune response in the production of pro-inflammatory cytokines induced by isoproterenol (ISO) toxicity.

Additional differentiation of the results suggested that oral pretreatment with SACS (40 and 80 mg kg(-1)) daily for a period of 35 days prevents cardiotoxicity by improving all the biochemical parameters studied in ISO-induced rats.

Taken altogether, alliin may be considered a supplement for the prevention and treatment of cardiotoxicity, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Preventive effect of S-allyl cysteine sulphoxide (Alliin) on mitochondrial dysfunction in normal and isoproterenol-induced cardiotoxicity in male Wistar rats: a histopathological study by Sangeetha T1, Darlin Quine S. (PubMed)

(2) Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol induced myocardial infarction in male Wistar rats by Sangeetha T1, Quine SD. (PubMed)

(3) High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity by Mitra MS1, Donthamsetty S, White B, Mehendale HM. (PubMed)

#Herbal #Arctostaphylos uva-ursi InhibitsType 4 Hypersensitivity Caused by #ContactDermatitis, Scientists Find

Kyle J. Norton

Scientists may have found a herbal medicine for the prevention and treatment of type 4 hypersensitivity with no side effects, according to studies.

Type 4 allergy or type 4 hypersensitivity is often called delayed-type hypersensitivity as the reaction takes several days to develop.

In other words, instead of happening right the way as that of other types, type 4 hypersensitivity typically develops at least 48 hours after exposure to an antigen.

The process that develops type 4 hypersensitivity involved the activation of the white blood cell cells in stimulating the release of cytokines and chemokines, and macrophages and cytotoxic CD8+ T cells associated with the body's adaptive immune response.

Compared to other types of allergy mediated by the antibody, type 4 allergy is a cell-mediated response.

Type 4 hypersensitivity can induce allergic contact dermatitis, occurred at the site where the antigen contacts the skin, then spread to other regions through contamination of the antigen.

Type 4 hypersensitivity is caused by atopic dermatitis, lung diseases associated with hypersensitivity, type 2 diabetes, and inflammation of the thyroid gland.

Treatment of type 4 hypersensitivity is totally depending on the severity of the disease. however, the most appropriate approach is to avoid the offending antigen.

Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.

The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc.

The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.

In the concern of the widespread Type IV hypersensitivity caused by contact dermatitis, researchers at Kinki University examined the combined effect of arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng. (Bearberry leaf) and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema, and adjuvant-induced arthritis.

Injection of arbutin at a dose of 50 mg/kg 24 h after the application rapidly decreased the swelling of type IV allergic sheep-induced edema and adjuvant-induced arthritis by picryl chloride (PC-CD) compared to no reaction at the divided doses of 50 mg/kg.

Arbutin (p.o.) plus indomethacin (s.c.) exerted highly inhibitory effects on the swelling of PC-CD and sheep red cell delayed-type hypersensitivity (SRBC-DTH) compared to that of indomethacin alone.

Furthermore, arbutin (p.o.) and indomethacin (s.c.) in a given portion were simultaneously administered, the inhibitory effect was more potent than that of indomethacin alone in both carrageenin-induced edema and adjuvant-induced arthritis.

The results clearly suggested that arbutin may increase the inhibitory action of indomethacin on PC-CD, and SRBC-DTH against type 4 hypersensitivity.

Moreover, in the comparison of water extract (UW-ext) from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf) on the antiallergic and anti-inflammatory activities of dexamethasone ointment, researchers found one or 2% UW-ext ointment did not inhibit the ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema.

However, combined with dexamethasone ointment (0.005 or 0.025%), UW-ext augmented the inhibitory effect of dexamethasone ointment (0.005 or 0.025%) on these allergic and inflammatory models with no side effects.


These findings showed that not all parts of herbal Arctostaphylos uva-ursi process anti-type 4 allergies, but combined with other therapy all parts augmented the significant anti-allergic and inflammatory activity with no side effects.

Additionally, the investigation of the antitype 4 allergies properties of the combined effect of 50% methanolic extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) and prednisolone also showed similar results as illustrated by the above 2 studies.

U-ext did not show an inhibitory effect on the swelling induced by PC-CD in divided doses of 100mg/kg immediately before and 16 h after the application of PC-CD, while it exhibited a significant therapeutic effect at a dose of 100 mg/kg or more once 24 h after the application.


Injection of the combination of U-ext (p.o.) and prednisolone (s.c.) simultaneously administered, exerted a greater inhibitory effect compared to that of prednisolone alone.

Researchers at the above studies wrote in the final report, "Bearberry leaf possesses a therapeutic effect against immuno-inflammation induced by PC-CD and also increases the inhibitory effect of prednisolone, and its active principle may be arbutin".

Taken together, herbal Herbal Arctostaphylos uva-ursi (Bearberry) may be considered a functional remedy for the prevention and combined with primary medicines for the treatment of type 4 hypersensitivity with no side effects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].[Article in Japanese] by Matsuda H, Nakamura S, Tanaka T, Kubo M.(PubMed)
(2) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. III. The combined effect of arbutin and indomethacin on immuno-inflammation].[Article in Japanese] by Matsuda H, Tanaka T, Kubo M.(PubMed)
(3) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. I. Combined effect of 50% methanolic extract from Arctostaphylosuva-ursi (L.) Spreng. (bearberry leaf) and prednisolone on immuno-inflammation].[Article in Japanese] by Kubo M, Ito M, Nakata H, Matsuda H.(PubMed)

#HealthyFood #Fenel is a Great Source of Antioxidants in the Inhibition of #Oxidativestress, Scientists Find

Kyle J. Norton

Fennel may be the next generative functional food with the potency in blocking the overexpression of free radicals in the induction of chronic illness, some scientists suggested.

Free radicals are highly reactive molecules with unpaired electrons that cause oxidation by stealing an electron from other molecules to give rise to a chain activity. Once free radical starts its domino effect, it can not be stopped until two free radical species react with each other to form a stable, non-radical adduct or are inhibited by the presence of antioxidants.

Antioxidants, on the other hand, are stable molecules that inhibit oxidation caused by free radicals.

The relationship between free radicals and antioxidant are summarized by Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health ", "A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence the application of an external source of antioxidants can assist in coping with this oxidative stress".

These explanations suggested that the intake of antioxidants from the food sources in the stimulation of antioxidant enzymes in the body is beneficial in maintaining good health, However, the doctors continued, "Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years".

Overexpression of free radicals or imbalance of the ratio of free radicals and antioxidants in the body can initiate oxidative stress. A prolonged period of oxidative stress in the human body plays a major part in the development of chronic and degenerative illnesses such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, and cardiovascular and neurodegenerative diseases.

Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The functional herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, relieve PMS,...

Fennel is an excellent source of natural antioxidants and contributed to the daily antioxidant diet. The functional food is found to process a free radical scavenging activity, particularly in the application of its phenolic and flavonoids.

In the examine the effects of fennel essential oil in the presence of overexpression of free radicals, researchers found, that injection of the oil exerts a strong antioxidant activity in comparison with butyrated hydroxyanisole and butylated hydroxytoluene., however, injection of ethanol and water extracts of fennel showed less effective compared to essential oil.

Furthermore, in the evaluation of the essential oils of the fruits of three organically grown cultivars of Egyptian fennel (Foeniculum vulgare var. azoricum, Foeniculum vulgare var. dulce, and Foeniculum vulgare var. vulgare) in antibacterial and antioxidant effects, researchers showed that all three cultivars contain a great source of trans-Anethole, estragole, fenchone, and limonene.

All phytochemicals demonstrated significant activity in free radical scavenging, inhibited lipid peroxidation, and metal chelation.

Additional differentiation suggested that essential oils from the azoricum and dulce cultivars were more effective antioxidants than that from the vulgare cultivar and essential oils from 3 species display similar antimicrobial activities against two species of fungi, two species of Gram-negative and two species of Gram-positive bacteria.

More importantly, in the examine the effect of essential oil on fennel (Foeniculum vulgare) lipophilic secondary metabolites, researchers at the Avicenna Tajik State Medical University, discovered that
* The oil exhibited moderate antioxidant activities.

* The antioxidants in the essential oil are found to protect the healthy cells and stimulate the expression of free radicals in exerting cytotoxic activity against HeLa (human cervical cancer), Caco-2 (human colorectal adenocarcinoma), MCF-7 (human breast adenocarcinoma), CCRF-CEM (human T lymphoblast leukemia) and CEM/ADR5000 (adriamycin resistant leukemia) cancer cell lines;

* The most effective of the IC50 values are between 30-210 mg L-1.

These results suggested essential oil from fennel is processed as a great source of antioxidants with the function of balancing the ratio of free radicals in the body, thus preventing the initiation of oxidative stress.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chemical composition, antimicrobial and antioxidant activities of essential oils from organically cultivated fennel cultivars by Shahat AA1, Ibrahim AY, Hendawy SF, Omer EA, Hammouda FM, Abdel-Rahman FH, Saleh MA(PubMed)
(3) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M8(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)

#Curcumin #Extract From #Herbal #Turmeric Inhibits Chronic Prostatitis through their Anti- Inflammatory Activity, Researchers Say

Kyle J. Norton


Prostatitis is a condition associated with the inflammation of the prostate and the areas around the prostate.

According to the statistics provided by the American Family Physician, approximately 8.2 percent of men in the US are living with prostatitis. The conditions account for 8 percent of visits to urologists, and up to 1 percent of visits to primary care physicians.

Believe it or not, in 2000, prostatitis cost over $84 million, including the charge of diagnosis and treatment.

The most common symptoms of prostatitis are painful, difficult, and/or frequent urinating, groin pain, rectal pain, abdominal pain and/or low back pain, fever, chills, and body aches.

In severe cases, patients may also experience symptoms of urethral discharge, painful ejaculation or sexual dysfunction, and blood in the urine.

The exact causes of prostatitis are not identified, some researchers suggested that nerve damage in the lower urinary tract caused by surgery or trauma to the area has been found to induce prostatitis in patients.

Conventionally, most cases of prostatitis are treated by antibiotics in cases of infection, alpha-blockers to relax the bladder neck, and muscle fibers, and anti-inflammatory medicine to ease pain and discomforts.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential and natural ingredient for the treatment of inflammatory diseases such as chronic prostatitis/ chronic pelvic pain syndrome type III (CP/CPPS), researchers examined the effect of turmeric on chronic bacterial prostatitis.

Phase II, the randomized, single-blinded, placebo-controlled clinical trial included 60 patients who were examined by the University of Catania from June 2015 to January 2016 we enrolled 60 consecutive due to CP/CPPS III.

At the end of the experiment, the treatment group showed a significant improvement in the National Institutes of Health Chronic Prostatitis Symptom Index, IIEF-5 (+ 3.5; p &lt; 0.01), particularly other symptomatic parameters compared to placebo.

Participants were then allocated to receive treatment (Group A) or placebo(Group B). Treatment consisted of rectal suppositories of Curcumin extract 350 mg (95%) and Calendula extracts 80 mg (1 suppository/die for 1 month). Patients of Group B received 1 suppository/die for 1 month of placebo.

The efficacy of the treatment with Curcumin and Calendula was associated with the reduction of inflammatory cytokines and inflammatory cells.


Based on the findings, Dr. Morgia G, the lead researcher said, "In this phase II clinical trial, we showed the clinical efficacy of the treatment with Curcumin and Calendula in patients with CP/CPPS III".

Taken together, turmeric used alone or combined with Calendula may be considered supplements for the prevention and treatment of chronic bacterial prostatitis and chronic pelvic pain syndrome, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A phase II, randomized, single-blinded, placebo-controlled clinical trial on the efficacy of Curcumina and Calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III by Morgia G1, Russo GI, Urzì D, Privitera S, Castelli T, Favilla V, Cimino S. (PubMed)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)

#Phloretin From #Apples or [6]-gingerol From Ginger SupplementationGinger Inhibit the Formation of AGEs Associated with the Onset of #Diabetes and #DiabeticComplications

Kyle J. Norton

Ginger may have a potential and profound effect in regulating abnormally high blood sugar, some scientists suggested. 

Hyperglycemia is a condition of abnormally high levels of glucose in the bloodstream.

According to the statistic, approximately, 30.3 million Americans, or 9.4% of the population, had diabetes. Approximately 1.25 million American children and adults have type 1 diabetes. And, hyperglycemia is a hallmark sign of diabetes(both type 1 diabetes and type 2 diabetes) and prediabetes.


Some researchers suggested that people who are living under prolonged periods of stress due to chronic illness or stress are associated with a higher risk of high blood sugar.

Others suggested that an unhealthy diet such as high in saturated and trans fat, red meat, processed food, and lack of physical exercise have many folds increased the risk for the onset of hyperglycemia.

In fact, shift workers accompanied by an unhealthy lifestyle are jointly associated with the risk of type 2 diabetes.

Dr. Shan Z, in the concerns of the rotating night shift work and lifestyle factors in the risk of diabetes, used the data of Nurses' Health Study (1988-2012) and Nurses' Health Study II (1991-2013) and compared to the 143 410 women without type 2 diabetes, cardiovascular disease, or cancer at baseline, said, " The multivariable-adjusted hazard ratios for type 2 diabetes were 1.31 (95% confidence interval 1.19 to 1.44) per five-year increment of the duration of rotating night shift work and 2.30 per unhealthy lifestyle factor (ever smoking, low diet quality, low physical activity, and overweight or obesity)".


"For the joint association of per five-year increment rotating night shift work and per unhealthy lifestyle factor with type 2 diabetes, the hazard ratio was 2.83 (2.15 to 3.73) with a significant additive interaction (P for interaction <0.001)".

How severe of the diabetes risk in nurses on the rotating shift accompanied by an unhealthy diet? According to the team, during 22-24 years of follow-up, 10 915 cases of incident type 2 diabetes occurred.

The risk of type 2 diabetes is even higher if each individual factor is also included.

These results clearly suggested that the onset of diabetes is not caused by a single factor but is associated with a group set of risk factors.

Luckily, most people with some of the above risk factors do not develop hyperglycemia or type 2 diabetes.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

In finding a natural ingredient and whole food for the treatment of diabetes and diabetes complications, researchers examine the action of ginger in the diabetic population.

Selected mice fed either a high-fat diet or a standard diet for a period of 17 weeks were given phloretin isolated from apples and [6]-gingerol isolated from ginger supplemented at two different doses.

Application of phloretin and [6]-gingerol inhibited the formation of AGEs by suppressing the receptor for advanced glycation end products (RAGE).

Where Advanced glycation end products are proteins or lipids that become glycated as a result of exposure to sugars. The products can substantially worsen certain chronic diseases such as diabetes.

Phloretin or [6]-gingerol supplementation significantly reduced plasma glucose, alanine aminotransferase, aspartate aminotransferase, AGEs, and insulin levels and enhanced GSH/GSSG ratio.

These results suggested that phloretin or [6]-gingerol supplementation not only inhibited the oxidative stress that causes abnormally high blood glucose but also improved insulin resistance against the onset of diabetes complications in mice fed with a high-fat diet.

Furthermore, the assessment of the effect of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus with the consumption of 1600 mg ginger versus 1600 mg wheat flour placebo daily for 12 weeks, also found that ginger reduced fasting plasma glucose, HbA1C, insulin, HOMA, triglyceride, total cholesterol, CRP and PGE₂ significantly compared with the placebo group (p < 0.05).

Ginger improved fasting glucose and parameters associated with the onset of insulin resistance without inducing any side effects.

Dr. Arablou T after taking into account co and confounders said, "Ginger improved insulin sensitivity and some fractions of lipid profile, and reduced CRP and PGE₂ in type 2 diabetic patients. Therefore ginger can be considered an effective treatment for the prevention of diabetes complications".

Taken altogether, ginger may be considered a functional food for the prevention and treatment of diabetes and diabetes complications induced by abnormally high blood glucose.


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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway by Sampath C1, Rashid MR1, Sang S2, Ahmedna M. (PubMed)
(2) The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(3) Zerumbone, a Phytochemical of Subtropical Ginger, Protects against Hyperglycemia-Induced Retinal Damage in Experimental Diabetic Rats by Tzeng TF1, Liou SS2, Tzeng YC3, Liu IM. (PubMed).
(4) Rotating night shift work and adherence to an unhealthy lifestyle in predicting the risk of type 2 diabetes: results from two large US cohorts of female nurses by Shan Z1,2, Li Y2, Zong G2, Guo Y3,4, Li J2,3, Manson JE3,5, Hu FB2,3,6, Willett WC2,3,6, Schernhammer ES3,6,7, Bhupathiraju SN2, (PubMed)

#Phytochemical 3,3'-Diindolylmethane Inhibits Parameters Associated wiht An Increased Risk of #BreastCancer, According to Studies

Kyle J. Norton

Cancer is a class of diseases in which a group of cells grow and multiply disorderly and uncontrollably in our body.

Breast cancer (malignant breast neoplasm) is a medical condition characterized by irregular cell growth in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

There are also rare cases that breast cancer started in other areas of the breast.

In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the US and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Breast cancer is first noticed as a painless lump in the breast or armpit and is most often discovered by the women themselves.

In some cases, breast cancer can also be noticed by the woman partner or during the doctor a routine physical exam.

In the early stage of breast cancer, patients may experience symptoms of a lump (mass) in the breast. and in the armpit (lymph nodes), nipple discharge, inverted or retracted nipple, scaly or pitted skin on a nipple, persistent tenderness of the breast, and unusual breast pain or discomfort.


If you experience some of the aforementioned symptoms, please check with your doctor right away to rule out the possibility. Breast cancer diagnosed in the early stage have a 5-year survival rate of 100%.

However, at the advanced stage, due to the oversize of the tumor, patients may experience symptoms of bone pain (secondary tumors in bone), shortness of breath (secondary tumors in the lung) Headaches, neurological pain, or weakness (secondary tumors in the nervous system) accompanied by the general symptoms shared with other types of cancer.


Out of many risk factors associated with the onset of breast cancer, genetic preposition may be one of the major predictions of the disease.


Dr. Amir Mehrgou, the lead scientist said, "Early detection of mutation carriers in these genes, in turn, can play an important role in its prevention. Because this disease has a high prevalence in half of the global population, female screening of reported mutations in predisposing genes, which have been seen in breast cancer patients, seems necessary. In this review, a number of mutations in two predisposing genes (BRCA1 and BRCA2) occurred in patients with a family history,..".

In fact, women who carry the BRCA1 and BRCA2 genes have a 68% lifetime risk to develop breast cancer.

In seeking a potential compound for the treatment of breast cancer, researchers examined the promising 3,3'-Diindolylmethane (DIM) anticancer effects of breast cancer patients with high HER-2/neu levels.

DIM combined with Herceptin enhances the effectiveness of Herceptin by significantly reducing cancer cell viability, and increasing apoptosis-induction and inhibition of colony formation, compared to the use of the chemo drug alone.

The combination also induced cancer cell death by inhibiting the expression of proteins associated with the production of proinflammatory cytokines, cancer cell division, and proliferation and migration.

Furthermore, the combination also significantly exhibited the expression of miR-200, which plays an essential in blocking tumor cell invasion and metastasis and reduction of FoxM1 expression in the promotion of cancer cell proliferation.

Dr. Ahmad A, the lead scientist said, "DIM-plus Herceptin therapy could be translated to the clinic as a therapeutic modality to improve treatment outcome of patients with breast cancer, particularly for the patients whose tumors express high levels of HER-2/neu".

Moreover, in order to know more information about DIM anti-breast cancer activity, researchers investigated the bioactive compound against the transcription factor Forkhead Box M1 (FoxM1) associated with aggressive human carcinomas, including breast cancer.


3,3'-diindolylmethane (DIM), a nontoxic dietary chemopreventive agent showed to inhibit the FoxM1 in various breast cancer cell lines, according to the observation of gene transfection, real-time reverse transcription-PCR, and Western blotting.

Similar to the aforementioned results, DIM combined with Taxotere enhanced Taxotere-induced growth inhibition of breast cancer cells and decreased the invasive capacity of breast cancer cells compared to treatment alone.

Most importantly, the combination treatment also significantly inhibited tumor growth in severe immunodeficiency (SCID) mice,

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of breast cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3, 3'-Diindolylmethane enhances the effectiveness of Herceptin against HER-2/neu-expressing breast cancer cells by Ahmad A1, Ali S, Ahmed A, Ali AS, Raz A, Sakr WA, Rahman KM. (PubMed)
(2) 3,3'-Diindolylmethane enhances taxotere-induced growth inhibition of breast cancer cells through downregulation of FoxM1 by Ahmad A1, Ali S, Wang Z, Ali AS, Sethi S, Sakr WA, Raz A, Rahman KM. (PubMed)
(3) The importance of BRCA1 and BRCA2 gene mutations in breast cancer development by Amir Mehrgou 1 and Mansoureh Akouchekian. (PMC)