#Phytochemical Cucurbitacin B Isolated from Cucumber Combined with Cisplatin Enhance Chemotherapy on Laryngeal Cancer

Kyle J. Norton

Laryngeal cancer is a medical condition characterized by abnormal cell growth in the tissues of the larynx due to the alternation of cell DNA.
Larynx, also known as the voice box is a tube above the windpipe (trachea) in the neck and in front of the food pipe.

Most cases of laryngeal cancer start in the cell on the surface of the inner lining of the larynx, before penetrating into the deeper layers to form a tumor.

At the very early of cell alternation, patients are asymptomatic. However, as the tumor continues to grow, the cancer cell may infect other healthy tissues a distance away through the blood and fluids distribution.

Laryngeal cancer shares the general symptoms with other cancer including unintended pain, weight loss, loss of appetite, fatigue, and gastrointestinal discomforts accompanied by specific symptoms of a lump or swelling in your neck. a long-lasting cough, a persistent sore throat or earache, and difficulty breathing. in severe cases.

Sometimes, patients may vomit blood due to the oversize tumor which has pressed on the nearby blood vessels.

Out of many prevalent risk factors, smoking tobacco (cigarettes, pipes, cigars) is considered a major culprit that increases the risk of developing laryngeal cancer in the Western world.


Dr. A Altieri, the lead scientist wrote, "Cancer of the larynx is extremely rare in individuals who neither smoke nor drink alcohol (Austin and Reynolds, 1996). The risk rises with increasing levels of smoking and drinking, each agent approximately multiplying the effects of the other (Elwood et al, 1984; Blot, 1992; Dosemeci et al, 1997; Talamini et al, 2002). The risk of laryngeal cancer is 10–20-fold higher in current smokers than in non-smokers".

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find potential and natural chemotherapy for the treatment of laryngeal cancer, researchers examined whether cucurbitacin B can also enhance the sensitivity of Hep-2 laryngeal cells to cisplatin.

The study included the evaluation of the proliferation, cell cycle distribution, and apoptosis in Hep-2 cells treated with either cucurbitacin B, cisplatin, or a combination.

According to the tested results, Hep-2 cells treated with a cucurbitacin B/cisplatin combination display synergistic effects on growth inhibition, cell cycle arrest, and apoptosis induction, compared to single-agent cucurbitacin B or cisplatin-treated cells.

Moreover, Hep-2 cell lines treated with the cucurbitacin B/cisplatin combination demonstrated a significantly reduced level of p-Stat3, compared to single-agent treated cells.

Where overexpression of p-STAT3 is an indication of a poor prognosis biomarker in cancer.

Additionally, cucurbitacin B/cisplatin-treated Hep-2 cells also demonstrated a significant reduction of the protein associated with regulation in the cell cycle and anti-apoptosis, compared to single-agent cucurbitacin B or cisplatin-treated cells.

Based on the results, researchers said, "These results suggest that the cucurbitacin B/cisplatin combination treatment may be a potentially useful therapeutic option for individuals diagnosed with laryngeal cancer".

In order to reveal more information about cucumber's anti-laryngeal cancer properties, scientists evaluated the combined antitumor effect of cucurbitacin B with docetaxel on Hep-2, a human laryngeal cancer cell line.

The combination of cucurbitacin B and docetaxel produced greater efficacy in growth inhibition, cell cycle arrest at the G2/M phase, and apoptosis induction similar to those of the aforementioned study compared to single-agent treatment.


The efficacy of the combined effect of cucurbitacin B and docetaxel anti-Hep-2 was attributed to the suppression of the expression of proteins involved in tumor proliferation and migration.

In vivo, the combination of cucurbitacin B with docetaxel also synergistically inhibited tumor growth in a mouse xenograft model.

Taken together, cucumber processed with a high amount of cucurbitacin B may be considered supplements combined with conventional medicine for the treatment of laryngeal cancer, pending the confirmation of the larger sample size and multicenter human study.



Intake of cucurbitacin B in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin by Liu T1, Peng H, Zhang M, Deng Y, Wu Z. (PubMed)
(2) Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer by Liu T1, Zhang M, Zhang H, Sun C, Yang X, Deng Y, Ji W. (PubMed)
(3) Cessation of smoking and drinking and the risk of laryngeal cancer by A Altieri,1 C Bosetti,1 R Talamini,2 S Gallus,1 S Franceschi,3 F Levi,4 L Dal Maso,2 E Negri,1and C La Vecchia. (PMC)

#Herbal #Andrographis Reduces the Risk and Early Onset of Alzheimer's disease through Various Mechanisms, According to Studies

Kyle J. Norton

Herbal Andrographolide processed an anti-cognitive impairment effect in the prevention of the early stage of dementia, a study conducted by a renowned institute suggested.

Andrographis paniculata also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...

Alzheimer's disease is a brain disorder correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer. Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies, or social life. Alzheimer's gets worse over time, and it is fatal.

According to the joint study led by the Pontificia Universidad Catolica de Chile, oral administrated natural product (Andrographolide, ANDRO) isolated from Andrographis paniculata in species Octodon degus (degu) exhibited the recovery of spatial memory and learning performance, through regulated phosphorylated tau protein and amyloid-beta aggregate maturation in cell survival in inducing Alzheimer's disease.

Dr., the lead author in the joint study said, "(Andrographolide, ANDRO) inhibited) neural damage associated with aging processes and the behavioral and neuropathological hallmarks of aging-related diseases such as AD"

Additionally, Andrographolide also displayed inhibitory activity against forming of amyloid-beta (Aβ)42 through suppression of NF-κB, a protein in regulated cell survival and function of microglia in activated response to brain damage and immunological stimuli together with the reduction in the production of inflammatory cytokines.

In an animal study, mice treated with Andrographolide increased neural progenitor cell proliferation and the number of immature neurons in the hippocampus compared to age-matched control mice.

Moreover, ANDRO stimulated neurogenesis increasing the number of newborn dentate granule neurons in various parts of the brain.

The study also found that the efficacy of reduced symptoms and protection against the early onset of AD is the result of the stimulation of neurogenesis in the hippocampus.

Taking together, Andrographis paniculata is sure consisted of a therapeutic potential to protect the development of Alzheimer's disease through various mechanisms, however, intake of large amounts daily should be taken with care.


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Sources
(1) Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response by Seo JY1, Pyo E1, An JP1, Kim J1, Sung SH1, Oh WK1.(PubMed)
(2) Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus) by Rivera DS1, Lindsay C2, Codocedo JF2, Morel I3, Pinto C2, Cisternas P4, Bozinovic F5, Inestrosa NC6. (PubMed)
(3) Andrographolide Stimulates Neurogenesis in the Adult Hippocampus by Varela-Nallar L1, Arredondo SB1, Tapia-Rojas C2, Hancke J3, Inestrosa NC4.(PubMed)

#Chastetreeberry Essentialoil Processes Anti Oligomenorrhea and Amenorrhea Symptom Activity, According to Studies

Kyle J. Norton

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region. It has been used in herbal medicine for thousands of years as an aphrodisiac herb and is considered a Queen herb in treating menstrual problems and discomforts by taking it for a prolonged period of time. There was a report that reports chaste tree berry stems and leaves used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria,

Oligomenorrhea is irregular menstruation and defined as a condition of an infrequent period or a woman's menstrual period that does not occur at an interval of greater than 35 days.

Amenorrhea is defined as a health condition of absence of a period.

In a study of 37 women with oligomenorrhea and 30 women with amenorrhea received 50 drops of Phyto Hypophyson, and Agnus castus-containing homeopathic preparation, or placebo 3 times a day over 3 months or 3 cycles, conducted by Universitäts-Frauenklinik, suggested that women with sterility and oligomenorrhea, a treatment with Phyto Hypophyson L can be recommended over a period of 3-6 months(1). Dr. Veal L. suggested that Vitex agnus-castus or a blend of essential oils may be used to treat amenorrhoea or scanty/irregular periods(2).

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References
(1) [The efficacy of the complex medication Phyto-Hypophyson L in female, hormone-related sterility. A randomized, placebo-controlled clinical double-blind study].[Article in German] by Bergmann J1, Luft B, Boehmann S, Runnebaum B, Gerhard I.(PubMed)
(2) Complementary therapy and infertility: an Icelandic perspective by Veal L.(PubMed)

#Cranberry Fruit Extract Processes Weight Maintenance and Promotes the Effective Management of Obesity, Researchers Say

Kyle J. Norton

Obesity is a chronic condition characterized by excess body fat that has accumulated over time. People with a BMI of over 30 are considered obese.

Similarly, overweight is a condition of excess body weight relative to height. People with a BMI ranged from 25 to 29.9 is considered overweight.

According to the statistics, over 30 % of the American population is obese. Obesity has been found to induce adverse effects nearly every system of the human body, leading to an increased risk of numerous diseases, including diabetes and cardiovascular disease.

Furthermore, the rate of obesity in the US and Canada continues to climb at an alarming rate, leading to significant burdens to the country's economy and health care system.

Epidemiologically, most common symptoms of obesity are breathlessness, increased sweating, inability to cope with physical activity, feeling very tired every day, back and joint pains, low confidence, and self-esteem and feeling isolation

According to the CDC, the most common complications associated with obesity are coronary heart disease, stroke, type 2 diabetes, cancer of the breast, colon, endometrial, gallbladder, kidney, and liver, and sleep apnea.

Currently, there is no effective treatment for the disease. However, some researchers suggested that combating the powerful environmental factors that influence eating and physical activity may be the best approach to reducing the risk of obesity.

Dr. EunSeok Cha, the lead scientist wrote, "Obesity among young adults is a growing problem in the United States and is related to unhealthy lifestyle habits such as high caloric intake and inadequate exercise. Accurate assessment of lifestyle habits across obesity stages is important for informing age-specific intervention strategies to prevent and reduce obesity progression".

And, "Overweight and obese young adults can promote their cardiometabolic health with healthy lifestyles. To take action, young adults need practical and strategic dietary advice about beverage choices, diet quality, and macronutrient and micronutrient sources. In addition, increasing overall activity and minimizing sedentary behavior needs to be emphasized for young adults to achieve physical activity goals.".

In other words, changing to a healthy lifestyle such as a healthy diet and moderate exercise, over long-term obesity is controllable.


Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.


On finding a potential compound for the treatment of diseases associated with oxidative stress, researchers investigated the anti-adipogenic effect of the polyphenol-rich extract obtained from chokeberry Aronia melanocarpa (Michx.) Elliot, raspberry Rubus idaeus L., bilberry Vaccinium myrtillus L., and cranberry Vaccinium macrocarpon Aiton fruits.

According to the results from the analysis, the preparations ranging from 25-100 μg/mL not only significantly decreased lipid accumulation but also inhibited the expression of reactive oxygen species in the adipocytes without showing cytotoxicity.

The Real-time PCR analysis also revealed that the extract at a concentration of 100 μg/mL suppressed the process of cell differentiation of adipogenesis and lipogenesis that converts triglyceride for storage in fat via inhibiting the gene expression (PPARγ) of energy metabolism and genes associated with adipogenesis (C/EBPα) and lipogenesis (SREBP1).

In 3T3-L1 adipocytes, the expression of adiponectin involved in regulating glucose levels as well as fatty acid breakdown was increased by 4.4 fold whereas hormone leptin found in high levels of obese subjects was decreased by 90% by the extracts.

Based on the findings, researchers said, " the analyzed extract may be a promising source of bioactive compounds that support long-term weight maintenance and promote the effective management of obesity".

Taken together, cranberry combined with other herbal medicine may be considered a remedy for the management of obesity, pending the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory activity of chokeberry, bilberry, raspberry, and cranberry polyphenol-rich extract towards adipogenesis and oxidative stress in differentiated 3T3-L1 adipose cells by Kowalska K1, Olejnik A1, Szwajgier D2, Olkowicz M. (PubMed)
(2) Lifestyle habits and obesity progression in overweight and obese American young adults: Lessons for promoting cardiometabolic health by EunSeok Cha, PhD, MPH, MSN, CDE, RN, Margeaux K. Akazawa, MPH, Kevin H. Kim, PhD,*Colleen R. Dawkins, MSN, FNP-BC, RD, Hannah M. Lerner, BS, Guillermo Umpierrez, MD, FACP, FACE, and Sandra B. Dunbar, PhD, FAAN, FAHA, RN. (PMC)

#Herbal Ashwagandha Root #Extract Immediates and General Memory in People with Mild Cognitive Impairment (MCI), Researchers Suggest

Kyle J. Norton

Memory is one of the major functions of the brain that collects and stores data or information which are retrieved when needed. In other words, memory is the retention of information over time that have a strong influence on future action.

Memory impairment is a condition of partial or complete loss of memory, depending on the quality of the neuron that has been affected.

Memory impairment other than the physical impact is a progressive disease that can lead to permanent loss of memory due to the gradual loss of neurons in the brain.

Memory impairment can be acute or chronic.

In acute impairment, memory is a temporary loss in most cases associated with physical impact on the brain that causes injury of neurons.

Chronic memory impairment is the loss of memory that can get worse over time found mostly in the elderly with neurodegenerative diseases, such as dementia.

In elderly or aging-induced memory loss is associated with the deterioration of a region of the brain involved in the formation and retrieval of memories, the hippocampus, and the reduced hormones and protein that protect and repair brain cells and stimulate neural growth.

The most common risk factors associated with memory loss in the general population are long-term use of certain medications, excessive alcohol drinking, smoking, drug abuse, depression, nutrient deficiency, stroke, and daily stress.

However, some researchers suggested the rise of memory impairment in the elderly probably is correlated to the promotion of the Western diet over the past few decades.

Dr. Scott E. Kanoski, the lead scientist in the review of the risk cognitive impairment in the Western diet consumption wrote, "Intake of saturated fats and simple carbohydrates, two of the primary components of a modern Western diet, is linked with the development of obesity and Alzheimer's Disease".

And, "Western diet intake is associated with cognitive impairment, with a specific emphasis on learning and memory functions that are dependent on the integrity of the hippocampus".

The results clearly stated if you are a Western diet follower, you are at a higher risk of memory impairment compared to healthy diet individuals.

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In finding a potent compound for the treatment of brain health, researchers examined the efficacy and safety of ashwagandha (Withania somnifera (L.) Dunal) on memory and cognitive functioning in adults with mild cognitive impairment (MCI).

The prospective, randomized, double-blind, placebo-controlled study included 50 adults assigned to the treatment of either ashwagandha-root extract (300 mg twice daily) or placebo for eight weeks.

According to the analysis of Wechsler Memory Scale III subtest scores for logical memory, at week 8, the ashwagandha treatment group exerted significant improvements in both immediate and general memory, compared with the placebo group.

Futhermore, verbal paired associates I (p = 0.042), faces I (p = 0.020), family pictures I (p = 0.006), and logical memory II (p = 0.006) scores were also significantly increased compared to placebo.
According to the scores of Eriksen Flanker task (p = 0.002), Wisconsin Card Sort test (p = 0.014), Trail-Making test part A (p = 0.006), and the Mackworth Clock test (p = 0.009), ashwagandha treatment group also displayed a significantly greater improvement in executive function, sustained attention, and information-processing speed also compared to placebo.

Based on the findings, researchers said, "Ashwagandha may be effective in enhancing both immediate and general memory in people with MCI as well as improving executive function, attention, and information processing speed.".

Taken altogether, Ashwagandha may be considered a functional herb for the improvement of brain health, pending the result of larger sample size and multicenter study


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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

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Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions by Choudhary D1, Bhattacharyya S2, Bose S. (PubMed)
(2) Western Diet Consumption and Cognitive Impairment: Links to Hippocampal Dysfunction and Obesity by Scott E. Kanoski1 and Terry L. Davidson. (PMC)

#Antioxidant #Alliin Inhibits Parameters Associated with the Onset of MetabolicSyndrome, Scientists Find

Kyle J. Norton

Hyperglycemia is a medical condition characterized by abnormally high levels of glucose in the bloodstream
Although hyperglycemia is a hallmark in patients with diabetes, the condition can also occur in people without diabetes due to a certain medical condition such as pneumonia in the elderly.

Dr. Yuan Lin, the lead scientists in the examination of hyperglycemia in patients with an
acute pancreatitis (AP) wrote, "Hyperlipidemia, fatty liver, hypertension, endoscopic retrograde cholangiopancreatography treatment, acute hyperglycemia, elevated lactate dehydrogenase, and creatine kinase, decreased calcium, and AB blood type were risk factors for hyperglycemia development after AP".

The most common causes of hyperglycemia are associated with an uncontrolled diet, improper use of insulin, and skipping diabetic medication.

The most common symptoms of hyperglycemia are increased thirst frequent urination, fatigue (weak, and unintended weight loss. In severe cases, some patients may also experience symptoms of headaches, trouble concentrating, and blurred vision.

If you have experienced some of the aforementioned symptoms, you may have abnormally elevated high blood sugar.

Untreated hyperglycemia can lead to serious complications requiring emergency care, such as a diabetic coma. Over the long term, persistently mild hyperglycemia can lead to complications in the eyes, kidneys, nerve damage and heart disease, and stroke.

By following the guidelines and recommendations in the management of blood glucose accompanied by healthy and moderate exercise, diabetics may do just fine against hyperglycemia.


Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

In finding a potential compound for the treatment of hyperglycemia, researchers examined the effect of alliin against metabolic risk factors in diet-induced obese (DIO) mice.

Selected C57BL/6J DIO diet-induced obese mice are treated with drinking water with or without alliin (0.1 mg/ml) for 8 weeks.


Oral administration of alliin enhanced glucose homeostasis, increased insulin sensitivity, and improved the lipid profile in the DIO mic without affecting the body weight, adiposity, or energy balance.

In other words, alliin inhibited hyperglycemia selectively without normalizing the adiposity tissues' inappropriate responses of energy intake and energy expenditure.


Based on the tested results, researchers found that the efficacy of alliin in the inhibition of hyperglycemia is partly associated with the modulation of the intestinal microbiota composition, typically decreased Lachnospiraceae and increased Ruminococcaceae.


In order to reveal more information about alliin antihyperglycemic activity, researchers examined the production and therapeutic efficiency of alliin extracted from garlic leaves of plants grown under ex-situ and in-situ conditions.

According to the results of alliin aqueous leaf extracts (from ex-situ and in situ grown plants) were given to normal and alloxan-induced diabetic rats for five weeks, under in situ conditions, alliin extract lowered the serum glucose, triglycerides, total lipids, and total cholesterol, low-density lipoprotein (LDL)-, and very-low-density lipoprotein (VLDL)-cholesterol in diabetic rats by ~54%, 15%, 14%, 20%, 24%, and 15% compared to 35%, 14%, 10%, 12%, 17% and 11% from the ex-situ grown plants.

Furthermore, compared to glibenclamide, the leaf extract of plants lowered serum enzyme levels (alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase) associated with liver oxidative stress toward the normal.

Moreover, The histopathological alteration in the pancreas caused by alloxan was also inhibited markedly by leaf extract.


Based on the findings, Dr. Nasim SA, the lead scientist wrote, "These findings demonstrate leaf extract obtained from plants grown under in situ conditions possess higher therapeutic efficiency in comparison with leaf extract obtained from plants grown under ex-situ condition".

In other words, geographic growth may influence the therapeutic potential of phytochemicals in plants.

Taken together, alliin may be considered a supplement for the prevention and treatment of hyperglycemia, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice by Zhai B1, Zhang C1, Sheng Y1, Zhao C2, He X1,3, Xu W1,3, Huang K1,3, Luo Y. (PubMed)
(2) Alliin obtained from leaf extract of garlic grown under in situ conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats by Nasim SA1, Dhir B, Kapoor R, Fatima S, Mahmooduzzafar, Mujib A. (PubMed)
(3) Risk Factors of Hyperglycemia in Patients After a First Episode of Acute Pancreatitis: A Retrospective Cohort by Yuan L1, Tang M, Huang L, Gao Y, Li X. (PubMed)

#Broccoli or #BroccoliSprouts Show no Effects on #Thyroid-Stimulating Hormone, Free Thyroxine, and Thyroglobulin, According to Studies

Kyle J. Norton

Thyroid disease is a medical condition that causes a malfunction of the thyroid.

Hyperthyroidism is a condition in which the thyroid gland is overactive and produces too much thyroid hormones.

The most common symptoms of hyperthyroidism are excessive sweating, heat intolerance, increased bowel movements, shaking, nervousness, agitation, anxiety, rapid heart rate, palpitations, irregular heart rate, weight loss, fatigue, weakness...

Hypothyroidism is a condition in which the thyroid gland is underactive and produces very little thyroid hormones.

Symptoms of hypothyroidism are depended on the severe stage of the disease. as it progresses slowly over years such as weight gain and fatigue, vitiligo and alopecia areata, chronic constipation, urticaria and puffiness of hands and feet, yellow ivory skin, coarse rough dry skin, alopecia periorbital edema, amenorrhea, dyspareunia, PCO, PMS and breast tenderness, menstrual irregularities and infertility,...

Thyroid toxicity that affects the function of the thyroid gland not only causes thyroid dysfunction but also induce thyroid autoimmune disease.

According to Dr. Catherine Sutcliffe, the lead scientist in the study of "Endocrine Disruption of Thyroid Function" wrote, "The common factor in the direct thyroid toxicity mechanisms so far outlined is the reduction of thyroid hormone production and secretion. The reduction of thyroid hormones (T4 or T3) results in compensatory increased secretion of TSH due to the concomitant diminution of feedback control (see Figure 11.3)".

And, "It is important to note that increased TSH stimulation of the thyroid produces the same histopathological effects irrespective of the mechanism by which TSH is increased including thyroid growth evidenced by increased size and weight".

There are a number of causes of thyroid toxicity including short and long term intake of some medications (sunitinib has been found to cause thrombocytopenia and hypoglycemia in 62 patients) and xenobiotics.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The vegetable has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

In finding thyroidal toxicity of sulforaphane, a redox-active natural product present in cruciferous vegetables like broccoli. Broccoli sprout, researchers examined the effect of the phytochemical sulforaphane effect on Nrf2 (NFE2-related factor 2) that leads to thyroid dysfunction or thyroid autoimmune disease.


According to the results of the biochemical measures of thyroid function and thyroid autoimmunity in 45 female participants in a randomized clinical trial at baseline and after 84 days of beverage administration, researchers found that

* Broccoli sprout-derived products shows promising activity for the prevention of oxidative stress-related diseases.

* Sulforaphane did not affect the serum levels of thyroid-stimulating hormone, free thyroxine, and thyroglobulin.

* More importantly, sulforaphane does not affect thyroid autoimmunity status.

Based on the findings, researchers said, "These results provide evidence in favor of the safety of chemoprevention strategies that target the activation of Nrf2 to protect against environmental exposures and other oxidative stress-related pathologies".

Taken altogether, Broccoli sprouts may is safe for the prevention and treatment of oxidative stress-related diseases without causing thyroidal toxicity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial by Chartoumpekis DV1, Ziros PG2, Chen JG3, Groopman JD4, Kensler TW1, Sykiotis GP. (PubMed)
(2) Thyroid Toxicity (Science Direct)