Saturday, 19 August 2023

#Asparagus Root #Extract Processes Anti Inflammatory Activity through Regualting the Immune Response, Researchers Suggest

Kyle J. Norton

Asparagus is a flowering plant belonging to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, northwest Germany, northern Africa, and western Asia, used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.
Asparagus may be the next potential whole food medicine in the inhibited expression of pro-inflammatory cytokines in inducing fever, pain, and swelling in the affected location,...

Inflammation is a natural expression by the immune system in the induction of white blood cells for the protection of our body against infection with foreign invasion.

According to the Korea Institute of Oriental Medicine, in an investigation of chronic skin inflammation, using 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced mouse ear edema, administration at 200mg/kg (i.p.) of ethanolic extract from Asparagus cochinchinensis Merrill (ACE)expressed strong anti-inflammatory effect through inhibited topical edema in the mouse ear, and substantial reductions in skin thickness and tissue weight, inflammatory cytokine production,.....

Dr. Lee DY, the lead author in the study said, "ACE is an effective anti-inflammatory agent in murine phorbol ester-induced dermatitis" and " the compound may have therapeutic potential in a variety of immune-related cutaneous diseases."

The study of pharmacological properties of Asparagus racemosus root extracts (AR), also addressed the potential use of extract formulation for topical and/or transdermal drugs to provide anti-inflammatory activity, due to its significant attenuation involved in systemic inflammation, without causing toxicity to experiment monocytic leukemia cell line THP-1.


Furthermore, the extract from asparagus also exerts an inhibitory effect on pro-inflammatory cytokines, namely interleukin 1β and tumor necrosis factor α, and on the production of nitric oxide in free radical-mediated lipid oxidation stimulated by lipopolysaccharide in regulated immune response in vitro.

Some researchers insisted the properties of anti-inflammation of asparagus may also be due to the presence of phytochemical saponin contents in comparison to the group treated with crude saponin extracts in the rat paw-edema and the control group.

Taken together, Asparagus may have a potential anti-inflammatory effect in reduced risk and treatment of chronic inflammatory diseases. The efficacy is not due to a single ingredient in the food but the whole food.


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Sources
(1) Anti-inflammatory effects of Asparagus cochinchinensis extract in acute and chronic cutaneous inflammation by Lee DY1, Choo BK, Yoon T, Cheon MS, Lee HW, Lee AY, Kim HK.(PubMed)
(2) Anti-inflammatory activity of liposomes of Asparagus racemosus root extracts prepared by various methods by Plangsombat N1, Rungsardthong K2, Kongkaneramit L3, Waranuch N4, Sarisuta N5.(PubMed)
(3) Effects of Chlorophytum arundinaceum, Asparagus adscendens and Asparagusracemosus on pro-inflammatory cytokine and corticosterone levels produced by stress by Kanwar AS1, Bhutani KK.(PubMed)
(4) Anti-inflammatory activity of crude saponin extracts from five Nigerian medicinal plants by Hassan HS1, Sule MI, Musa AM, Musa KY, Abubakar MS, Hassan AS.(PubMed)

#Healthyfood #Cranberry Processes Anticancer Activity, According to Studies

Kyle J. Norton

Cancers are a class of chronic and medical conditions characterized by cells growth irregularly and disorderly in the tissue of a specific organ.

Most cases of cancer start in the cell on the surface of the inner lining of organ tissue caused by the alternation of the cell DNA.

At the early stage, due to the very small size of the tumor, patients may not experience any symptoms. However, as the cancer progression, cancer cells may penetrate into deeper layers, before colonizing entire organs. At this stage, the primary cancer cells can travel a distance away from the original site to infect other healthy tissue and organ via fluid and blood circulation.

According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes, based on the 2013–2015 data.

In 2017, about15,270 children and adolescents ages 0 to 19 were diagnosed with cancer. Cancer in the same year also causes the death 1,790 of children and adolescents Americans.

As of today, researchers do not know the exact cause of cancer neither they know why people with the same health condition and family history, some are susceptible to DNA alternation in facilitating the onset of cancer, while others do not.

There are many prevalent factors associated with cancer onset, including an increase of age, excessive alcohol consumption, exposure to chemical toxins and sunlight, and infectious pathogens.

Most common factors that cause the rise of cancer, including colorectal cancer in the Western world according to Dr. Omran S, the led author in the study of "Dietary and Lifestyle Risk Factors for Colorectal Cancer in Apparently Healthy Adults in Jordanian Hospitals" are dietary patterns, sedentary lifestyle, and other practices.

In CRC risk, the doctor continued, aging with the mean age of 57.0 ± 8.56 years, male gender with less than secondary school formal education.

And, the commonest risk factors for CRC among the participants were overweight or obesity (76.1 %), lack of exercise (71.6 %), limited consumption of vegetables (70.8 %), smoking (60.6 %), over-consumption of red meat (56.3 %), and diabetes mellitus (24.1 %)".

However, most people with some of the aforementioned risk factors have never developed cancer.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound that processes chemopreventive activity, researchers assessed the anti-cancer activities of Chlorhexidine (CHX) and Cranberry against oral cancer cell lines.

According to the results of AW13516 (poorly to moderately differentiated squamous cell carcinoma of the tongue) and KB (Nasopharyngeal carcinoma) using Sulforhodamine B (SRB) assays, the CHX efficacy of 80.15% & 95.7% of growth inhibition against AW13516 & KB cell line respectively.

* Administration of CE (80µg/ml) showed no anti-cancer properties against the AW13516 cell line.

*However, CE inhibited 70.6% growth against the KB cell line.

Furthermore, both CHX and CE were less potential than the positive control drug Adriamycin, at the values of GI50, TGI, and LC50.

Based on the findings, researchers said, "CHX exhibited better anti-cancer properties than CE for both the oral cancer cell lines".

In other words, CE exerted anti-cancer activity depending on the types of primary cancer cells.

Taken together, cranberry may be considered a remedy for the prevention and treatment of cancer, depending on the types of primary cancer cells, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anticancer activity of chlorhexidine and cranberry extract: an in-vitro study by Khairnar MR1, Wadgave U1, Jadhav H2, Naik R. (PubMed)
(2) Cranberry and its phytochemicals: a review of in vitro anticancer studies by Neto CC. (PubMed)

#Antioxidant #Lycopene Inhibits #SkinCancer Associated with Enhancing the Expression of the Tight Junction Complexes, Researchers Say

Kyle J. Norton

Skin cancer is a medical condition associated with irregular cell growth in the skin tissues.
Most cases of skin cancer start in the cells on the surface of the outermost inner lining tissue before penetrating into deeper layers.

After growing in size at the advanced stage, the cells of the tumor may travel a distance away to infect other healthy tissue and organs through blood and fluid circulation.

The most common secondary metastasis of skin cancer is breast, lung, and colon.

Believe it or not, more people are diagnosed with skin cancer each year in the U.S. than all other cancers combined. As of today, there are 58 million Americans living with skin cancer.

Approximately, 1 in 5 Americans will develop skin cancer by the age of 70.

If you have experienced some of the symptoms such as a sore that doesn't heal or comes back after healing, pale white or yellow flat areas that look like scars, raised and scaly red patches, small, smooth, and shiny lumps that are pearly white, pink or red, a pink growth with raised edges and indents in the center and a growth that has small blood vessels on the surface of the skin, you may be on the early stage of skin cancer, please check with your doctor immediately.

The 5-year survival of all people with melanoma of the skin is 92% compared to 100% of those localized skin cancer.

Out of many prevalent factors that cause skin cancer, some researchers suggested exposure to UVB is one of most risk associated with skin cancer onset in the US.

Dr. Calzavara-Pinton P, the lead scientist said, "BCC is much more strongly related to measures of intermittent ultraviolet exposure (particularly those of childhood or adolescence) than to measures of cumulative exposure".

And, " In contrast, SCC is more strongly related to constant or cumulative sun exposure. Photobiological studies have clarified that sunlight and UVB radiation are complete carcinogens for AK and SCC although the relationship with UVA exposure is much less known".

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In the urgency to find a natural compound for the treatment of skin cancer without side effects, researchers evaluated the effect of lycopene, a kind of carotenoid inhibitory function on skin tumor cell migration.

In the human sSCC cell line COLO-16 selected for the study, the administration of lycopene inhibited the cell proliferation and migration of COLO-16 cells without affecting the normal keratinocytes.

Furthermore, the inhibitory activity was found by exhibiting Zonula occludens (ZO)-1, inhibition of ZO-1 expression, and its failure to accumulate at cell junctions (ZO-1 and claudin-1) have been found to induce cancer progression.

In other words, lycopene inhibited the SCC cell line COLO-16 proliferation by enhancing the expression of the tight junction complexes that regulate the permeability of epithelial against cancer cells.

Additionally, cell cycle division proteins (JNK and ERK ) in the induction of mitogen associated with the decreasing levels of ZO-1 and claudin-1 were also inhibited by the injection of lycopene.

More precisely, lycopene inhibited the progression of human sSCC cell line COLO-16 by reducing the proteins involved in promoting cell cycle division and increasing cancer cell permeability and autophagy,

Based on the findings researchers said, "This study indicates that lycopene might be a useful chemopreventive agent against cSCC".

Taken together, lycopene may be considered supplements for the prevention and treatment of skin cancer, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene upregulates ZO-1 and downregulates claudin-1 through autophagy inhibition in the human cutaneous squamous cell carcinoma cell line COLO-16 by Bi S1,2, Li L1, Gu H1, Li M1, Xu S1, Bu W1, Zhang M1, Zhou Z2, Chen X. (PubMed)
(2) Suppressive effects of lycopene and β-carotene on the viability of the human esophageal squamous carcinoma cell line EC109 by Ngoc NB1,2, Lv P1,3, Zhao WE1. (PubMed)

#Anethole found in #Fennel Exerts a Orotective Effect Against Micro Imbalance in Initiated #GastrointestinalDisorder, Researchers Say

Kyle J. Norton

Fennel may have a potential and therapeutic effect in reduced risk, progression, and treatment of gastrointestinal dysbiosis, some scientists suggested.

Dysbiosis is the most common gastrointestinal tract disorder, caused by imbalanced microbiota in the gastrointestinal tract, particularly in the small intestines.

Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

In the investigation of the effect of some herbal essential oil on the risk of dysbiosis, researchers found that essential oil isolated from fennel exerts lesser inhibited function in a reduced concentration of the growth of potential pathogens compared to the isolation of herbal Carum carvi, Lavandula angustifolia, Trachyspermum copticum, and Citrus aurantium var. Amara without inducing any adverse effects.

Further analysis also suggested that ingestion of fennel essential oil although decreases levels of bad micro bacteria concentration, they do not contribute to a substantial detrimental impact on beneficial members of the microflora.

The above differentiation was supported by the joint study conducted by the Scientific Board Member of Islamic Azad University, on 180-day-old broiler chicks to test the effect of the composition of Trigonella foenum-graecum (Fenugreek) and Foeniculum vulgare (Fenne) on antimicrobial activity of gut microflora traits.

Application of the composition to samples chick randomly assigned to groups fed with control diet (without additives), diet accompanied with 2 mentioned mixed powder plants (0.5% of total diet), diet with TF mixed powder plant and diet with FV mixed powder plant, at the end of the experiment, demonstrated a significant improvement of balance of the gastrointestinal microflora, through an expression of increased average daily feed intake (ADFI), average daily gain (ADG).

Additionally, the efficacy of the composition also decreased the concentration of the number of G- bacteria (NGB), the number of Coli form bacteria compared to the sample taken before the experiment.

Indeed, Trigonella foenum-graecum (Fenugreek) and Foeniculum vulgare (Fennel) treated group displayed an enormous anti-antimicrobial activity of the gut compared to the control group.

In tested porcine gut, anethole, the bioactive compound found in essential oil isolated from fennel displayed a substantial antimicrobial activity against commensal and pathogenic bacteria, through inhibited the chloride secretion with function in major determinant of mucosal hydration throughout the gastrointestinal tract, induced by 5-HT metabolic signaling of gut microbes and theophylline adverse effect in induction of gut disorder.

At a dose of 0.5 mmol/L, anethole exerted a protective effect against micro imbalance in initiated gastrointestinal disorder by inhibition of excessive chloride secretion.

Taken together, the information finding suggested that fennel and its bioactive compound anethole may be considered as a functional herb for reduced risk, and progression and combined with standard medicine for the treatment of intestinal dysbiosis, without inducing intolerant side effects.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
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Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) Essential oils in the treatment of intestinal dysbiosis: A preliminary in vitro study by Hawrelak JA1, Cattley T, Myers SP.(PubMed)
(2) Effects of fenugreek and fennel seeds on growth performance and reducing the population of gut microflora in broiler chicks [2010] by Kalantar, M.,Dakhili, M.,(PubMed)
(3) EFFECT OF THE ESSENTIAL OILS THYMOL, E-ANETHOLE, AND ECINNAMALDEHYDE ON ACTIVE NUTRIENT ABSORPTION AND STIMULATED CHLORIDE SECRETION IN THE ISOLATED PIG GUT, Chapter 5 by JORIS MICHIELS

#Isothiocyanates (ITC) Found in #CruciferousVegetables Inhibit the Freeradical Induced Inflammation through Their Antioxidant Activity, Acccording to Studies

Kyle J. Norton

Inflammation is a natural expression by the immune system in induction of white blood cells for protect our body against infection with foreign organisms,

Cruciferous vegetables are a group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.

In a randomized controlled trial in healthy young adults, isothiocyanates found in cruciferous vegetables exhibited anti-inflammatory effects through altered serum concentrations of interleukin (IL)-6, IL-8, C-reactive protein (CRP)), in increased increases in the presence of inflammation in the body tumor, and necrosis factor (TNF) α,, involved in systemic inflammation.

Intake of Cruciferous Vegetables has been shown to reduce the circulation of proinflammatory cytokines, namely IL-6 through inhibiting the expression of an abnormal function of gene Glutathione S-Transferase Theta 1(GSTT1) metabolism in lower levels of glutathione, the antioxidant with anti-inflammatory properties.


Dr. Navarro SL, the lead researcher said, " IL-6 concentrations were significantly lower on day 14 of (the double-dose cruciferous) (2xC) and (cruciferous plus apiaceous (carrot family) 1xC+A diets than with the basal diet,...respectively]" and " Twenty-four-hour urinary isothiocyanate excretion was not associated with any of the inflammation markers overall; however, IL-6 was inversely associated with total isothiocyanate excretion in GSTM1".

In support of the above study, isothiocyanates (ITC) from cruciferous vegetables showed to increase levels of serum of Glutathione S-transferases (GST), the enzymes that detoxify a broad range of free radicals in reduced risk of inflammation, particularly in GSTM1-null women.

Furthermore, the phytochemical also increased GSTA1/2, the antioxidant enzyme in GSTM1-null/GSTT1-null men.

Taken together, the intake of Cruciferous Vegetables regularly is associated to lower the effect of proinflammatory cytokines, particularly in adults with gene GSTT1.


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Sources
(1) Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults by Navarro SL1, Schwarz Y2, Song X2, Wang CY2, Chen C2, Trudo SP3, Kristal AR2, Kratz M2, Eaton DL4, Lampe JW2. (PubMed)
(2) Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes by Navarro SL1, Chang JL, Peterson S, Chen C, King IB, Schwarz Y, Li SS, Li L, Potter JD, Lampe JW. (PubMed)

#Healthyfood #Carrot Chemical Compounds Process Anti-Pathogenic Microorganisms Properties, Scientists Reveal

Kyle J. Norton

Carrots may have a profound and positive effect in gobbling up foreign microbial organisms before they can cause infection and damage to the host tissue, some scientists suggested.
The results of the veggie inhibition of micro-bacterial expression in an increased risk of infection were demonstrated by respectable institutes, including Iowa State University and Université de Monastir.

Infectious tissue caused by microbial organisms can induce transmissible disease or communicable diseases through the production of toxins.

The most common symptoms of infection are a fever. This is the result of the reaction of the immune response in stimulated overproduction of pro-inflammatory cytokines to protection the damage or injuries against micro pathogens.

However, over repression of pro-inflammatory factors can also induce tissue damage and forming of scars.

Other common symptoms also include chills and sweats, cough, sore throat, nasal congestion,....and burning or pain with urination

Some researchers suggested that most people with a balance of antioxidants, produced by tissue enzyme and free radicals are normally performed quite well against microorganisms during the time of infection.

Unluckily, people with a weakened immune systems caused by reduced levels of antioxidant enzymes may need to gobble up some anti-inflammatory agents to speed up the recovery.

Conventional antibiotics may be helpful, however, they can cause severe adverse effects.

Carrot, a root vegetable with orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.

In the investigate the effect of essential oils extracted from Daucus carota L. (Apiaceae) seeds in inhibited the spread of microbial organisms through comparison of 4 volatile compounds β-bisabolene (mean content of 39.33%), sabinene (8.53%), geranyl acetate (7.12%), and elemicin (6.26%), researchers found that application of all compounds exert strong activity in inhibited expression of Gram-positive (Staphylococcus aureus) and two Gram-negative bacteria (Escherichia coli and Salmonella typhimurium).

The result of efficacy probably was due to carrot seed extract's protection of cell membrane against microorganisms in initiated cell infection

Normally, infectious agents invade the cell membrane as the entry point to alternate DNA of the healthy cells.

In vitro, injection of all major compounds also showed a potential effect against Candida albicans, a pathogenic yeast.

Furthermore, the essential oil of carrot seed extract also exerted similar antibacterial and antifungal activities compared to the individual compound.

Some researchers suggested that antioxidants may also have a profound effect in the initiated expression of free radical cytotoxicity in facilitated damage and death of microorganisms, particularly in the infectious cells.

Interestingly, the precipitated cytotoxicity induced by reactive oxygen species and carrot antioxidants did not cause harm to healthy cells.

Also, the expression of antioxidants in the found compound ameliorated the immune response to protect our body against the stimulation of microorganisms in initiated production of inflammatory cytokine without reduced immune activity.

Overexpression of proinflammation is not only associated with increased symptoms of swelling, pain, and fever but also increased risk of cell damage and apoptosis in the site of infection, leading to abnormal healing skin.

Additionally, in the analysis of the carrot essential oil from flowers and roots of Daucus carota L. ssp. Mauritius obtained by hydrodistillation, researchers at the Université de Monastir reported that out of thirty-two and six compounds were identified in flower and root oils, phenolic derivatives (76.3%), myristicin (31; 29.7%), and dillapiole (32; 46.6%) constituted to main fraction demonstrated most protective effect in the inhibition of a series of common human pathogenic bacteria.

According to the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) assays, the found chemical compound also inhibited some clinically and environmentally isolated strains.


The evidence suggested that carrots with abundant bioactive compounds may be used as a functional food for reduced risk and treatment of micro bacterial infection.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) Variation of the chemical composition and antimicrobial activity of the essential oils of natural populations of Tunisian Daucus carota L. (Apiaceae) by Rokbeni N1, M'rabet Y, Dziri S, Chaabane H, Jemli M, Fernandez X, Boulila A.(PubMed)
(2) Flower and root oils of the tunisian Daucus carota L. ssp. maritimus (Apiaceae): integrated analyses by GC, GC/MS, and 13C-NMR spectroscopy, and in vitro antibacterial activity by Jabrane A1, Jannet HB, Harzallah-Skhiri F, Mastouri M, Casanova J, Mighri Z.(PubMed)

#RawGarlic Combined with Radiotherapy Induces Apoptosis of Lung Cancer in the G2/M Stage, Researchers Show

Kyle J. Norton

Many researchers have raised questions about the quality of the herbs because geographic differences, time of growth and harvest, etc. may affect their's potency. I do believe, these questions can only be answered by experienced herbalists.

Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.

Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. A most common form of primary lung cancers is derived from epithelial cells. In the Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistics.

A recent study suggested that garlic may be used as a chemoprevention and treatment of lung cancer.

According to the study by Medical Research Center, College of Medicine allyl sulfur compounds and garlic extract found in garlic exhibited anti nonsmall cell lung cancer cell line effects through interference on tumor cell division and tumor cell proliferation.


Benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells, oil-soluble organosulfur compounds in garlic induced suppression of cell proliferation, cell cycle regulation, attenuation of ROS formation, inhibition of DNA damage, after administration.

The examination of the association between raw garlic consumption and lung cancer, a case-control study conducted between 2005 and 2007 in Taiyuan, China, showed that compared with no intake, raw garlic intake is associated with a lower risk of development of lung cancer with a dose-response pattern.

In fact, the Epidemiologic data collected by face-to-face interviews using a standard questionnaire among 1,424 lung cancer cases and 4,543 healthy controls also supported the negation of garlic intake and lung disease and suggested that garlic may potentially serve as a chemopreventive agent for lung cancer.

Dr. Yang GQ, the lead researcher at the 107th Hospital of the People's Liberation Army said, "Black garlic extract (BGE) could have a significant inhibitory action on the growth of lung cancer Lewis cells. The combination of BGE and radiotherapy (by 60Co gamma) significantly induced Lewis cells' apoptosis in the G2/M stage".

Whole-food garlic in reducing the risk and treatment of lung cancer probably due to the effect of its phytochemicals. Adding a portion of garlic to your diet is beneficiary for increased protection against lung cancer development.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


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Sources
(1) Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines by Hong YS1, Ham YA, Choi JH, Kim J.(PubMed)
(2) Inhibitory effects of S-allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells by Wang K1, Wang Y1, Qi Q1, Zhang F1, Zhang Y2, Zhu X1, Liu G1, Luan Y1, Zhao Z3, Cai J4, Cao J4, Li S4.(PubMed)
(3) Raw Garlic Consumption and Lung Cancer in a Chinese Population by Myneni AA1, Chang SC2, Niu R3, Liu L4, Swanson MK1, Li J5, Su J5, Giovino GA6, Yu S5, Zhang ZF2, Mu L7.(PubMed)
(4) Raw garlic consumption as a protective factor for lung cancer, a population-based case-control study in a Chinese population by Jin ZY1, Wu M, Han RQ, Zhang XF, Wang XS, Liu AM, Zhou JY, Lu QY, Zhang ZF, Zhao JK.(PubMed)
(5) [Radiosensitization effect of black garlic extract on lung cancer cell line Lewis cells].[Article in Chinese] byYang GQ1, Wang D, Wang YS, Wang YY, Yang K.(PubMed)