#Beets Exhibit Hepatoprotective Effects through Anti Liver Toxicity Activity, Researchers Say

Kyle J. Norton

Beet may be considered as a functional food to protect the liver against any forming of liver disorders a renowned institute proposed.

Liver diseases are a class of diseases characterized by the disordered function of the liver, including cirrhosis, hepatitis, hepatitis B, hepatitis C, nonalcoholic liver disease, non-infectious liver diseases, benign liver tumors, liver cancer,......


Beet, best known as beetroot or garden beet, belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

According to Dr. Hari Singh Gour Vishwavidyalaya, Beta vulgaris Linn. (BV, Chenopodiaceae) leaves extract showed a significant effect in protecting the liver against hepatoxicity, measured by levels of serum markers enzymes together with antioxidants.

In vitro studies, n-butanol fraction of BV leaves (BVBF) isolated from beet, at doses of 50, 100, and 200 mg/kg exhibited liver protective action against ethanol-induced hepatic toxicity by the restoration of biochemical changes in liver tissues.

Furthermore, in carbon tetrachloride (CCl(4))-induced liver toxicity injured rats, orally administrated ethanolic extract of Beta vulgaris roots exerted a profound hepatoprotective activity at doses of 1000, 2000, and 4000 mg/kg.

Moreover, in the finding of new phytochemicals isolated from beetroot, researchers found that vitexin 7-O-beta-D-glucopyranoside (3), and vitexin 2''-O-beta-D-glucopyranoside, the new compounds also exhibited hepatoprotective effect at rates of 65.8 and 56.1%, respectively in rat induced liver toxicity model.

More importantly, others' newly differentiated flavonoids, 2",2"'-di-O-α-rhamnopyranosyl-vicenin II, a di-C-glycosyl flavone, and herbacetin 3-O-β-xylopyranosyl- (1"' --> 2")-O-β-glucopyranoside extracted from leaves of beet, once again demonstrated hepatoprotective effects in the intoxicated rat by the administration of acetaminophen.

Additionally, the newly acquired compounds above also demonstrated hypolipidemic activity in reduced risk of liver diseases in rats with a high-fat diet.

Taken together, beet is a potent functional food with plenty of liver-protective phytochemicals used for the prevention and treatment of liver disease.

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Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.
Source
(1) Protective role of Beta vulgaris L. leaves extract and fractions on ethanol-mediated hepatic toxicity by Jain NK1, Singhai AK.(PubMed)
(2) Hepatoprotective activity of Beta vulgaris against CCl4-induced hepatic injury in rats by Agarwal M1, Srivastava VK, Saxena KK, Kumar A.(PubMed)
(3) Norisoprenoids and hepatoprotective flavone glycosides from the aerial parts of Beta vulgaris var. cicla by Kim I1, Chin YW, Lim SW, Kim YC, Kim J.(PubMed)

Xixian Tongshuan Preparation Including #Herbal #Angelica Processes Neuro-Protective Activity through Its Anti Inflammatory Effects

Kyle J. Norton

Neuroprotection is a process to preserve the neuronal structure and/or function against the death or gradual death of neurons, including the use of medicines and herbs.

In other words, neuroprotection protects the neuronal integrity against the reduction in the rate of neuronal loss over time inducing neurological disease, including neurodegenerative disease.

Brain ischemia is a condition caused by insufficient blood flow to the brain to meet metabolic demand, leading to irreversible brain damage in severe cases.

In other words, brain ischemia induced the death of neurons of the affected tissues.

Brain ischemia can be classified into
* Focal ischemia is a condition caused by damage to a specific region of the brain; and

* Global ischemia is a condition of damage that affects the wide areas of brain tissue, leading to symptoms of impairments in vision, body movement, and speaking.

Dr. Jin-Moo Lee in the study of the issues of how the brain tissue responds to ischemia, said, "The brain is particularly vulnerable to ischemia. Complete interruption of blood flow to the brain for only 5 minutes triggers the death of vulnerable neurons in several brain regions, whereas 20–40 minutes of ischemia is required to kill cardiac myocytes or kidney cells".

And, "...the brain’s intrinsic cell-cell and intracellular signaling mechanisms, normally responsible for information processing, become harmful under ischemic conditions, hastening energy failure and enhancing the final pathways underlying ischemic cell death in all tissues, including free radical production, activation of catabolic enzymes, membrane failure, apoptosis, and inflammation".


Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen the heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

In finding a potential compound for the protection of the brain, researchers examined the neuroprotective effects of Xixian Tongshuan Preparation containing Ligusticum chuanxiong, Angelica Sinensis, Carthamus tinctorius, and Panax pseudo-ginseng.

According to chemical analysis, all constituents found in the formula work synergistically to protect the neurons against damage.

Furthermore, the formula inhibited the 5 glutamate receptors, TGFR-1, and VEGFR-2 in the mediation of the production of pro-inflammatory cytokines to induce neuron death and injury.

Moreover, a single component, such as neo-complanatoside and neo-carthamin, in Xixian Tongshuan Preparation could simultaneously act on different targets to exert their neuroprotective effects.

Based on the findings, researchers wrote, "This study explains the multi-target mechanism of anti-cerebral ischemic injury in neuroprotection at the molecular level, and provides a certain direction for the clinical application and experimental research of Xixian Tongshuan Preparation".

Taken together, herbal Angelica in combination with other herbal medicines may be considered a neuroprotective remedy, pending to larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Multi-target neuroprotective effect of Xixian Tongshuan Preparation against cerebral ischemia injury].[Article in Chinese] by Gu Y1, Zhao BW1, Chen X1, Luo YZ1, Zhang YL. (PubMed)
(2) Brain tissue responses to ischemia by Jin-Moo Lee, Margaret C. Grabb, Gregory J. Zipfel, and Dennis W. Choi. (PMC)

#Allyl‐isothiocyanate (AITC) Vapor Produced from Pure #Sinigrin Processes Anti Fungal Infection Activity, Researchers Suggest

Kyle J. Norton

A fungus is a primitive organism, including mushrooms, mold, and mildew found in the air, in the soil, on plants, and in water.
Fungi reproduce through tiny spores in the air if you inhale the spores, it may spread to cause a fungal infection that often starts in the lungs or on the skin.

People with a weakened immune system are more likely to be infected by fungi, including the fungus Aspergillus which causes lung infection.

Similar to other bacteria, there are millions of different fungal species on Earth, but only about 300 are known to infect people.

Conventionally, fungal infection is treated with antibiotics, including topical antifungal ointments or oral medications, depending on the severity of the disease.


If you are currently taking antibiotics for the treatment of fungal infection, please make sure that you know all possible side effects for preventive measures.

The most common symptoms of skin fungal infection are red and cracking or peeling skin accompanied by itching, depending on the location of the affected skin.


In a serious case of fungal lung infection, accumulated fungus fibers, blood clots, and white blood cells may appear in the lungs or sinuses, leading to coughing up blood or fever, chest pain, and difficulty breathing, depending on the size of the accumulation.

In seeking a natural compound for the treatment of fungal infection, researchers analyzed the antifungal infection of the roots of twelve plant spades from bath mycotrophic (hosts of YAM fungi) and non‐mycotropic (non‐hosts) families against the fungus Cladosporium cucumerimun Ellis & Arch.

2 species from the Brassicaceae such as Chenopodiaceae (Spinacea oleracea L., Beta vulgaris L.) showed a significant effect on fungus compared to Brassica kaber (DC.) Wheeler, Brassica napus L., Brassica campestris L., Thlaspi arvense L., Raphanus raphasnistrum L. which showed limited activity.

According to the TLC bioassay, Chloroform extracts of B. Kaber roots appeared to have the greatest quantity of extractable antifungal compounds.

Three antifungal compounds in chloroform extracts from B. Kaber roots were shown to be derived from glucosinolates, containing a high amount of sinigrin.


The finding strongly supports the use of sinigrin for the treatment of fungal infections.

Furthermore, in the differentiation of the fungitoxicity of allyl‐isothiocyanate (AITC) vapor produced from pure sinigrin against Penicillium expansum, the causal agent of blue mold on pears, 5 mg L−1 AITC‐enriched atmosphere showed the best control of blue mold by exposing fruits for 24 h.

At 1 × 103 conidia mL−1to almost 80% at 1 × 106 conidia mL−1, AITC decreased the percentage of infected wounds, compared to >98% of wounds infected in untreated fruits.

Moreover, AITC treatments were effective up to 24 h after inoculation for Conference and 48 h for Kaiser. AITC treatments also controlled a thiabendazole‐resistant strain of P. expansum, reducing the incidence of the blue mold by 90% in both cultivars.


Dr. M. Mari, at the end of the experiment, wrote, "The use of AITC produced from pure sinigrin or from Brassica junceadefatted meal may be an economically viable alternative to synthetic fungicides against P. expansum".

Taken together, sinigrin may be considered a supplement for the prevention and treatment of fungal infection, pending the confirmation of a large sample size and multicenter human study.

However, intake of bioactive in the form of supplements should be taken with extreme care, as liver toxicity may be induced if overdosed.

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)

#Sulforaphane (SFN) and Broccoli Sprout #Extract (BSE)Significantly Prevent Diabetes-induced Cardiac Dysfunction, Hypertrophy, and Fibrosis, According to Studies

Kyle J. Norton

Diabetes is a medical condition characterized by the failure of the body to utilize the insulin in converting glucose to energy, leading to high levels of glucose in the bloodstream.

Most cases of diabetes are associated with either beta cells of the pancreas died-off or insulin receptor site clogged-up by fat and cholesterol.

Diabetic complications in most cases are caused by long-term unmanaged hyperglycemia, a hallmark of diabetes.

The most common complication of diabetes is associated with the damage of tiny blood vessels that nourish the related organ and tissues, leading to the risk of developing microvascular and macrovascular complications. includes cardiovascular disease.

Diabetic cardiomyopathy is a complication of the heart muscle in people with diabetes, leading to heart failure that causes the reduced function of the heart to circulate blood through the body.
The most common symptoms of diabetic cardiomyopathy are the accumulation of fluid in the lungs or legs.

Dr. Adeghate E, in the examination of the diabetic cardiomyopathy associated with the structural changes in the myocardium of diabetes, wrote, " If left unmanaged, DM can lead to numerous long-term complications including micro- and macro-angiopathy and heart failure (HF)".

And, "Most diabetics usually die as a result of HF resulting from diabetes-induced coronary artery disease and cardiomyopathy. Coronary artery disease and cardiomyopathy are normally preceded by hyperglycemia (HG)".


In other words, management diabetes by preventing the onset of hyperglycemia is the most effective way to reduce the risk of diabetic cardiomyopathy in diabetes.


More precisely, by following a healthy diet to normalize the levels of HbA1c level, accompanied by moderate exercise, the risk of diabetic complications can be manageable.

Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. It has large flower heads, usually green in color and the mass of flower heads is surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.


With an aim to find a natural food for the prevention and treatment of diabetic cardiomyopathy, researchers examined the effect of broccoli sprout extract in an animal model.

The study included male db/db and age-matched wild-type (WT) mice given sulforaphane (SFN, an Nrf2 activator) and its natural source, broccoli sprout extract (BSE) by gavage every other day for 3 months, including vehicle (0.1 ml/10 g), BSE-low dose (estimated SFN availability at 0.5 mg/kg), BSE-high dose (estimated SFN availability at 1.0 mg/kg), and SFN (0.5 mg/kg).

According to the results of echocardiography and histopathological analysis, both BSE and SFN showed significant prevention of diabetes-induced cardiac dysfunction, hypertrophy, and fibrosis.

Furthermore, BSE, like SFN, significantly exhibited the Nrf2 transcriptional activity associated with the protective effect of oxidative damage triggered by injury and inflammation.

In other words, stimulating the Nrf2 function of the protein, BSE, and SFN significantly prevented cardiac oxidative damage and inflammation.


Moreover, BSE at high doses exerted a similar effect as those of SFN. particularly, in BSE at a high dose that works synergistically with SFN to prevent DCM.

Based on the findings, researchers said, "BSE could potentially be used as a natural and safe treatment against DCM via Nrf2 activation".

Taken altogether, broccoli sprout processed abundantly SFN may be considered supplements for the prevention and treatment of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice by Xu Z, Wang S, Ji H, Zhang Z, Chen J, Tan Y, Wintergerst K, Zheng Y, Sun J, Cai L. (PubMed)
(2) Structural changes in the myocardium during diabetes-induced cardiomyopathy by Adeghate E1, Singh J. (PubMed)

#Taraxasterol (TAR)Found in #Herbal #Dandelion (Taraxacum officinale) Inhibits the Proteins Associated with the Onset of of Rheumatoid Arthritis (RA)

Kyle J. Norton

Arthritis, one of the Musculoskeletal disorders (MSDs) degenerative disease, is a general term of joint inflammation, affecting over 21% of the US population.

There are over 100 different forms of arthritis and related diseases. Rheumatoid arthritis (RA), is the common form of arthritis involved in chronic low-grade inflammation.

Juvenile arthritis is an inflammatory disease affecting the synovium in children aged 16 or younger.

In other words, it is an autoimmune disorder caused by the immune system attacking some of the body's own healthy cells and tissues, in this case, the immune system attacks the joint tissue in the juvenile.

Genes that are associated with the risk of juvenile idiopathic arthritis include HLA-A. HLA-B. HLA-DPB1. HLA-DQA1. HLA-DQB1. HLA-DRB1. IL2RA. IL6, according to the National Institute of Health.

According to the statistic, the most common form of juvenile idiopathic arthritis (JIA), affects over 50,000 children in the United States alone.

Rheumatoid Arthritis (RA) is a type of arthritis associated with inflammation that affects mostly the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the age of 40, causing the diminished quality of life of many older adults.

According to the CDC, musculoskeletal disorders (MSDs) affect over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.

Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation.

A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.


Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

In finding a natural ingredient for the treatment of chronic inflammatory diseases, scientists examined taraxasterol (TAR), a bioactive active compound pentacyclic triterpenes isolated from the Chinese medicine herb Taraxacum officinale effects on rheumatoid arthritis (RA).

In Vitro and Vivo, the application of TRA significantly suppressed the proteins involved in the production of pro-inflammatory cytokines, namely tumor necrosis factor-α (TNF-α), IL-6, and IL-8 by blocking NOD-like receptor protein 3 (NLRP3) inflammasomes, activators of IL-1β secretion, particularly in the joints tissues of collagen-induced arthritis (CIA) mice.


Furthermore, the application of TRA also inhibited the enzymes involved in the production of matrix metalloproteinases (MMPs), like MMP-1 and MMP-3 in HFLS-RA in vitro, and degradation of the normal tissues.

Moreover, the injection of TRA also blocked nuclear factor kappa B (NF-κB) activation via modulating inhibitors of kappa B (IκB), IκB kinase (IKK) in the control of cytokines production and cell survival and transforming growth factor-β-activated kinase 1 (TAK1) to prevent the accumulation of ROS, resulting in cell death and inflammation.


Taken together, dandelion may be considered a remedy for the treatment of rheumatoid arthritis, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Taraxasterol suppresses inflammation in IL-1β-induced rheumatoid arthritis fibroblast-like synoviocytes and rheumatoid arthritis progression in mice by Chen J1, Wu W2, Zhang M1, Chen C. (PubMed)

3,3'-Diindolylmethane Inhibits the Matrix and protein associated with a Refuced Risk of #OvarianCancer in Vitro, Scientists Say

Kyle J. Norton

Ovarian cancer is a medical and chronic condition characterized by irregular cell growth in the tissues found either at the tail ends of the fallopian tubes or the ovaries.
According to the statistics provided by the American Cancer Society, ovarian cancer is one of the deadly reproductive cancer in women. Every year, the disease causes more deaths than any other cancer of the female reproductive system.

The lifetime risk of a woman getting ovarian cancer is 1/78 compared to the lifetime dying risk of 1/108.

The 5-year relative survival of all stages of ovarian cancer is 47%. However, women with ovarian cancer diagnosed at the localized stage have a 5 years survival rate of over 92%.

The exact causes of ovarian cancer are not identified. However, epidemiological studies suggested that women who have endometriosis, genetic preposition such as BRCA1 and BRCA2 gene, and acquired genetic mutation such as TP53 tumor suppressor gene are susceptible to the substantial risk of the development of the disease.

Besides sharing the common symptoms of other types of cancer, most ovarian cancer patients may experience symptoms of discomfort in the pelvic area, and changes in bowel habits, such as constipation. and a frequent need to urinate.

In seeking a natural product that processes anti-ovarian cancer properties, researchers examined the effects of 3,3'-diindolylmethane (DIM) on ovarian cancer cell viability, invasion, and sensitivity to chemotherapy.

According to the final results obtained by the ovarian cancer SKOV3 and A2780 cell lines treated by the 3,3'-diindolylmethane (DIM), DIM treatment not only potently suppressed the viabilities of ovarian cancer cells but also inhibited xenograft growth in nude mice.

Furthermore, according to the gene analysis, DIM inhibited phosphorylation of STAT3 and AKT proteins and proteins activated by STAT3 and AKT involved in cell growth and division and cell movement in the ovarian cancer SKOV3 and A2780 cell lines

Moreover, DIM inhibited the production of protein and genes associated with the production of a new blood vessel for the cancer cells to grow, promotion of cancer cell survival, and anti-apoptosis.

Additionally, in order to obtain more information about DIM anti-ovarian cancer effects, researchers examined the phytochemical activity of Interleukin (IL6) which has been found to be a major contributor to the initiation and progression of ovarian cancer.

During the experiment, human ovarian carcinoma-derived cell lines SKOV3 and A2780 treated with IL6 and/or DIM and subjected to in vitro proliferation, DIM inhibited the increase of ovarian cancer cell adhesion, migration, and invasion caused by the administration of IL-6 through deactivated the expression of protein STAT3 similar to that of the aforementioned study.

Importantly, DIM-induced ovarian cancer cells apoptosis is associated with the inhibition of the expression matrix metalloproteinases MMP-2 and MMP-9 associated with the pathologic relationship to cancer.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of ovarian cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane suppresses ovarian cancer cell viability and metastasis and enhances chemotherapy sensitivity via STAT3 and Akt signaling in vitro and in vivo by Zou M1, Xu C2, Li H3, Zhang X4, Fan W. (PubMed)
(2) IL6-induced metastasis modulators p-STAT3, MMP-2 and MMP-9 are targets of 3,3'-diindolylmethane in ovarian cancer cells by Zou M1, Zhang X2, Xu C. (PubMed)

Serum of Lycopene in the Body Is Associated with a Reduced Level of Oxidativestress, According to Studies

Kyle J. Norton

Oxidative stress is characterized by overexpression of free radicals in the body.
In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants caused by abundant free radicals and low levels of antioxidant enzymes produced by the body.

A free radical is an unstable atom with a single electron on the outermost ring. Given its nature, free radical readily donates or intercept an electron from another atom, leading to a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.

The antioxidant is a stable atom with a function to inhibit oxidation and comes either from dietary sources or produced by the body.

In contrast to general belief, free radical is also needed in moderated amounts for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.

According to studies, in cancer, oxidative stress has been found to induce cytotoxicity used in chemotherapy for the treatment of cancer by killing cancer cells.

However, in a healthy person, oxidative stress is harmful because it not only induces cells' lipid and protein oxidation but also causes the change of cell DNA, leading to diseases associated with oxidative stress including cancer, diabetes, and cardiovascular disease.

Ozone, certain pesticides, and cleaners, cigarette smoke, radiation, and pollution are some of the risk factors associated with the increased risk of oxidative stress.

Based on the oxidative stress theory of aging oxidative stress, oxidative stress is also the main culprit contributing to aging in humans.

Dr. Ilaria Liguori, the lead scientist said, "Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages".


Tomato is red, edible fruit, genus Solanum, belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a potential compound for the treatment of diseases associated with oxidative stress researchers examined the efficacy of lycopene a carotenoid commonly found in tomatoes and tomato products.

A total of 23 healthy postmenopausal women, 50-60 years old, were provided blood samples at baseline and following a one-month lycopene-depletion period according to the St. Michael's Hospital, Toronto, ON, Canada. PARTICIPANTS AND STUDY DESIGN.

Compared to the blood sample before and after experiment samples, a one-month lycopene-depletion period diet showed a significantly decreased antioxidant profile including serum lycopene, lutein/zeaxanthin, and glutathione peroxidase (GPx).

Furthermore, the diet also depressed levels of antioxidant enzymes superoxide dismutase (SOD), and catalase (CAT), significantly in the participants while increasing levels of lipid and protein oxidation.
In other words, tomatoes restrictive diet increased the risk of diseases associated with oxidative stress in postmenopausal women due to the increase of ROS and depletion of antioxidants in the tissues.

In order to reveal more information about the tomato effect against oxidative stress, researchers conducted a study to determine whether lycopene would act as an antioxidant to decrease oxidative stress parameters.
The study included a total of 60 postmenopausal women, 50-60 years old, following a 1-month washout without lycopene consumption,.

After a month, the participants were randomly divided into groups with 15 members each consuming either : (1) regular tomato juice, (2) lycopene-rich tomato juice, (3) tomato Lyc-O-Mato lycopene capsules, or (4) placebo capsules, twice daily for total lycopene intakes of 30, 70, 30, and 0 mg/day respectively for 4 months.


According to the tested assays, for 4 months significantly increased serum lycopene compared to placebo.

Moreover, the total serum antioxidant capacity (TAC) and decreasing lipid and protein peroxidation increased substantially in the groups treated with consumed juice or lycopene capsules compared to the placebo group.

Taken together, tomatoes and their major bioactive compound lycopene may be considered remedies for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.


Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausal women by Mackinnon ES1, Rao AV, Rao LG. (PubMed)
(2) Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women by Mackinnon ES1, Rao AV, Josse RG, Rao LG. (PubMed)
(3) Oxidative stress, aging, and diseases by Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6Domenico Bonaduce,1 and Pasquale Abete. (PMC)