#GreenTea Phenolic Compound Inhibits Retinal Degenerative Disease, According to Studies

Kyle J. Norton

Green tea phenolic content may have a sustainable and therapeutic effect in reducing the risk and progression of retinal degeneration, some scientists suggested.

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Retinal degeneration is a macular disease characterized by impaired vision, night blindness, retinal detachment, light sensitivity, tunnel vision, and loss of peripheral vision to total loss of vision.

The evaluation of green tea's effect on the risk of retinal degeneration was found to be implicated by several mechanisms through a number of aspects.

In ROS implication of oxidative stress-induced degeneration of the retina occurred in age-related macular degeneration (AMD) and glaucoma, application of green tea polyphenols epigallocatechin gallate (EGCG) exhibited antioxidant effect as free radical scavenger in ameliorated chain reaction of ROS in causing loss of neuron with direct effects of retinal function and reduced cytotoxicity of free radicals in induction of retinal cellular apoptosis.

Administration of green tea phenolic compound exerted 10 times more effective in the treatment of retinal degeneration, compared to potent medicine Trolox (vitamin E analogue) in attenuating lipid peroxidation caused by the nitric oxide donor, sodium nitroprusside (SNP), according to the study.


Particularly, green tea epigallocatechin gallate (EGCG) inhibited a significant decrease in photoreceptor-specific markers (RET-P1, rhodopsin kinase) which may be an indication of photoreceptor cells in the transition to degenerate prematurely, eventually resulting in blindness and an increase in the cell death marker caspase-3 caused by oxidative stress induced by injection of sodium nitroprusside (SNP)


According to the observation by Western blotting techniques, SNP was completely inhibited by EGCG injection in ameliorating the detrimental effects to the retina caused by SNP.

Dr. Zhang B, the co-author said, "Since oxidative stress has been implicated in retinal diseases like AMD and glaucoma this study provides "proof of principle" for the idea that daily intake of EGCG may help individuals suffering from retinal diseases where oxidative stress is implicated".

More interestingly, in BALB/cJ mice treated with either EGCG or saline via intraperitoneal (IP) injection, and then placed under constant cool white light-emitting diode (LED) light (10,000 lux) for 5 h, the EGCG treatment group showed a strong protective effect on the retina against light damage (LD) in compared to the control group.

According to the optical coherence tomography (OCT) and electroretinography (ERG), in the examine the retinal structure and function after LD indicated that the application of green tea EGCG improved significantly higher ERG amplitudes for all three wave types through inducing morphologic protection of photoreceptors also in compared to control.

Moreover, the green tea extract bio-compound also decreased oxidative stress through increase the mRNA level of the antioxidant expression of Sod2, a manganese-dependent superoxide dismutase (MnSOD) before LD and 24 h after LD.

Dr. Qi S1,, the lead author said, "The IP injection of EGCG attenuated the detrimental effects of bright light on the retinas of BALB/cJ mice by protecting the structure and function of the retina".

Importantly, in study to evaluate green tea EGCG effect in reduced glutamate-induced excitotoxicity in the retina, researchers conducted a study of female Wistar rats (n = 171) randomly signed into a normal control group (n = 9); saline control group with intravitreal saline injections (n = 54); NMDA control group with an intravitreal NMDA injection and intraperitoneal saline injections (n = 54); and NMDA study group (n = 54) receiving an intravitreal NMDA injection plus intraperitoneal EGCG (25 mg/kg) injections, observation of the groups at 2 weeks after additional injection of NMDA showed that group with treatment of intraperitoneal application of EGCG reduced a significantly less marked NMDA-associated loss of retinal ganglion cell, through inhibition of decreasing retinal ganglion cell layer (GCL), neurons located near the inner surface (the ganglion cell layer) of the retina of the eye in received visual information from photoreceptors via cell density and thickness of Thy-1 immunoreactivity in several areas of the immature and adult human brain in expression of retinal ganglion cell damage.


Taken together, there is no doubt that Epigallocatechin-3-gallate (EGCG), a major polyphenol of green tea, may be considered as a secondary therapeutic treatment used a combination with standard therapy for the protection and treatment of retinal degenerative disease


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate by Zhang B1, Osborne NN(PubMed)
(2) Neuroprotective effect of epigallocatechin-3-gallate against N-methyl-D-aspartate-induced excitotoxicity in the adult rat retina by Chen F1, Jiang L, Shen C, Wan H, Xu L, Wang N, Jonas JB(PubMed)
(3) Intraperitoneal injection of (-)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina by Qi S1,2, Wang C1,2, Song D2, Song Y2, Dunaief JL2.(PubMed)--

#Ginger's #CrudeExtract Processes Anti #ColonCancer by BlockingReceptorSignaling and Stimulating Apoptosis, According to Studies

Kyle J. Norton

Ginger may process certain bioactive compounds with a function to protect our body against the onset of colon cancer, some scientists found.
Colon cancer is a medical condition characterized by cell growth irregularly due to the alternation of DNA.

Most cases of primary colon cancer start in the cell on the surface of the inner lining of the colon. At this stage, most patients do not experience any symptoms or discomfort.

However, at the advanced stage, the cancerous cells in the colon not only can travel a distance far away to infect other healthy tissue and organ but also cause localized severe pain and symptoms as the proliferation of cancer have suppressed the nearby nerve cells and tissue.

Researchers do not know the exact causes of the disease. But they do know a history of polyps, ethnicity, high-fat diet, and low fiber, the increase in age, and the long-term infection of colon diseases are some of the prevalent risk factors associated with the onset and progression of colon cancer, according to epidemiological studies.

Out of that group of risk factors, the increase in age has been under intensified studies by many scientists.

According to the statistic, colorectal cancer is the third most common cancer in the US. The median age at diagnosis for colon cancer is 68 in men and 72 in women.

Early diagnosis of colon cancer can increase the 5 years of survival rate. Truly, in 39% of colon cancer diagnosed at the localized-stage disease, the five and ten years survival rate is 90%.

Dr. Elmer E. van Eeghen, the lead scientist in the cancer program at the Zaans Medisch Centrum, in the concerns of the increase in age impact on the development of colon cancer, launched an investigation on the influence of age and comorbidity on survival and cause of death in a non-selected population.


In the study "Impact of age and comorbidity on survival in colorectal cancer" wrote, "Patients with colorectal cancer are often excluded from clinical trials based on age or a poor performance score" and " In colon cancer patient age and comorbidity predict survival. This represents possible bias or a reduced survival benefit of treatment, and is an indication that colon cancer is not the prognosis-defining illness in the majority of patients".

These results furtherly confirm the prognosis of colon cancer in the aging population. However, most aging populations do not develop colon cancer.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The pungent kitchen spice has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural ingredient without side effects for the treatment of colon cancer, researchers at the Universiti Kebangsaan Malaysia, launch an investigation to examine the anti-tumor and anti-inflammation properties of the crude ginger extract against many types of cancer, including colorectal cancer.

The cells used in the experiment were divided into 4 groups: the first group represents HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represents cells treated with ginger and Gelam honey combined.

During the experiment, researchers showed that

* Ginger displays a significant effect in the inhibition of colon cancer cells by blocking the communication of a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell and regulating the cell cycle division.

* Ginger the concentration of the IC50 of 5.2 mg/m simulated the early apoptosis by enhancing the functional proteins associated with the execution of cancer cells and

* Decreasing the expression of proteins associated with cancer cells spreading.

Further differentiation of the anti-proliferative effects of ginger efficacy in enhancing the anti-cancer effects of 5-FU (5-fluorouracil) against a colorectal cancer cell line, HCT 116. researchers showed that ginger (IC50 of 3mg/mL) is more potent than Gelam honey (IC50 of 75 mg/mL) in inhibiting the growth of HCT 116 cells.

These results once against the suggested ginger extract could potentially enhance the chemotherapeutic effect of 5-FU against colorectal cancer.

Additionally, ginger in the study of cells was divided into 4 groups: the first group represents HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represents cells treated with ginger and Gelam honey combined researcher found that

Taken altogether, the ginger extract used alone or combined with honey might process significant and profound effects in reducing the risk of colon cancer and combined with primary therapy for the treatment of colon cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(2) Gelam honey and ginger potentiate the anti-cancer effect of 5-FU against HCT 116 colorectal cancer cells by Hakim L1, Alias E, Makpol S, Ngah WZ, Morad NA, Yusof YA. (PubMed)
(3) Impact of age and comorbidity on survival in colorectal cancer by Elmer E. van Eeghen, Sandra D. Bakker, Aart van Bochove, and Ruud J. L. F. Loffeld. (PMC)

#Chastetreeberry #EssentialOils Show a Strong Symptomatic Relief of Common Menopausal, Researchers Say

Kyle J. Norton

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, and used in herbal medicine for thousands of years as an aphrodisiac herb. It is considered a Queen herb in treating menstrual problems and discomforts by taking it for a prolonged period of time. There was a report that chaste tree berry stems and leaves were used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria,

Menopause is defined as a condition in which a woman is in the transition stage of permanent cessation of the ovaries' functions in egg production because of less production of estrogen and progesterone, signaling the end of the reproductive phase a woman's life. In menopause, menstruation has become irregular and slowly stops over time, but in some women, menstrual flow comes to a sudden halt.

In a self-administered questionnaire, containing 15 questions, sent to all gynecologists in private practice in Germany to evaluate the complementary and alternative medicine (CAM) in the treatment of climacteric disorders, 98% of the returnees are experienced with therapies of black cohosh (Cimicifuga racemosa), chaste tree (Vitex agnus castus) and St. John's wort(1).

According to the 1Royal Melbourne Institute of Technology (RMIT) University, Bundoora, although evidence from rigorous randomized controlled trials is lacking for the individual herb emerging pharmacological evidence supports a role for V. agnus-castus in the alleviation of menopausal symptoms(2).

Dr. Chopin Lucks B. in the trial of two essential oils (derived separately from leaf and fruit) of Vitex agnus castus indicated that both essential oils show a strong symptomatic relief of common menopausal symptoms(3).

Unfortunately, according to the University Hospital Hamburg-Eppendorf, Agnus castus showed no significant difference in the treatment of climacteric complaints(4) with a combination of Hypericum perforatum (St. John's wort) and Vitex agnus-castus (Chaste tree/berry) also showed the same(5).


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to 1000 free AND HEALTHY recipes and counting
http://kylejnorton.blogspot.ca/p/recipes.html

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
References
(1) The value of complementary and alternative medicine in the treatment of climacteric symptoms: results of a survey among German gynecologists by von Studnitz FS1, Eulenburg C, Mueck AO, Buhling KJ. (PubMed)
(2) Vitex agnus-castus (Chaste-Tree/Berry) in the treatment of menopause-related complaints by van Die MD1, Burger HG, Teede HJ, Bone KM. (PubMed)
(3) Vitex agnus castus essential oil and menopausal balance: a research update [Complementary Therapies in Nursing and Midwifery 8 (2003) 148-154] by Chopin Lucks B.(PubMed)
(4) Efficacy of Cimicifuga racemosa, Hypericum perforatum, and Agnuscastus in the treatment of climacteric complaints: a systematic review by Laakmann E1, Grajecki D, Doege K, zu Eulenburg C, Buhling KJ. (PubMed)
(5) Hypericum perforatum with Vitex agnus-castus in menopausal symptoms: a randomized, controlled trial by van Die MD1, Burger HG, Bone KM, Cohen MM, Teede HJ.(PubMed)

#Quercetin Aglycone and PAC DP-9 From #Cranberry Flavonoids Inhibit the Onset of #OvarianCancer, Researchers Suggest

Kyle J. Norton

The ovaries formed part of the female reproductive system are the oval-shaped ovum that connects to the fallopian tubes and attaches to the outer layer of the uterus via the ovarian ligaments.

Normally, the left and right ovary take a turn to release an egg every month. The ovaries also play a critical role in the production of estrogen and progesterone in the regulation of the process of women menstrual cycle including the release of an egg that migrates down the fallopian tube.

The most common disease associated with ovary dysfunction is polycystic ovary syndrome (PCOS), a hormonal disorder among women of reproductive age.

Ovarian cancer is a chronic and medical condition characterized by abnormal cells growth of ovarian cells which start on the surface of the inner lining of the ovarian tissue. Over time, after penetrating into deeper layers in the ovary, the cancer cell may travel a distance away to infect other nearby healthy tissues or organs, causing secondary metastasis.

Ovarian cancer is one of the most common cancers in the US. According to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, approximately 21,880 women in the United States were diagnosed with ovarian cancer. In the same year, ovarian cancer also causes the death of 13,850 American women.

The exact causes of ovarian cancer are not identified. However, epidemiologically, aging, genetic preposition, race, never pregnant women, family history, long-term chemical exposure, and menopausal hormone therapy MHT are some prevalent factors found in patients with the disease.

Dr. Prof. Rod Baber wrote, "Increased risk persisted after stopping the treatment for some years among women who had used MHT for more than 5 years".

And, "Overall, this increased risk was similar for European and North American perspective studies and for both estrogen-only and estrogen plus progestogen preparations but differed across the subtypes of epithelial ovarian cancers, being increased only in serious and endometrioid subtypes and decreased in mucinous and clear cell subtypes".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of ovarian cancer researchers examined the effect of cranberry flavonoids (flavonols and flavan-3-ols) SKOV-3 and OVCAR-8 ovarian cancer.

According to the tested assays, treatment with quercetin aglycone and PAC DP-9 from the cranberry flavonoids exhibited the strongest activity that induces apoptosis compared to other bioactive compounds.

The combination also inhibited the caspase-3 activation and PARP deactivation associated with apoptosis and increased the cisplatin sensitivity against the tested cell lines.

In SKOV-3 cells, PAC DP-9 also reduced the expression and activation of the epidermal growth factor receptor (EGFR) associated with cancer cell differentiation and proliferation.

Furthermore, quercetin aglycone and PAC DP-9 deactivated MAPK-ERK pathway and the overexpression of proteins associated with the promotion of cancer cell growth.

Moreover, the combination also promotes the gene expression of cancer suppression and arrested cell cycle progression.

Based on the findings, researchers said, "Overall, this study demonstrates promising in vitro cytotoxic and anti-proliferative properties of two newly characterized cranberry flavonoids, quercetin aglycone, and PAC DP-9, against ovarian cancer cells".

Taken together, cranberry-processed abundantly quercetin aglycone and PAC DP-9 may be considered a remedy for the prevention and treatment of ovarian cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells by Wang Y1, Han A2, Chen E2, Singh RK2, Chichester CO3, Moore RG2, Singh AP1, Vorsa N. (PubMed)
(2) Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells by Kim KK1, Singh AP, Singh RK, Demartino A, Brard L, Vorsa N, Lange TS, Moore RG. (PubMed)
(3) Menopausal hormone therapy and ovarian cancer by Prof. Rod Baber. (PMC)

#Carotenoid Intake Regularly and Daily Is Associated with Beneficial Skeletal Effects in Women with Osteoporosis, Researchers Suggest

Kyle J. Norton

Carrots may have a profound and positive effect on improving bone health, some scientists suggested.
Osteoporosis is a bone disease characterized by the inability of the body to produce bone to make up for bone loss, leading to the loss of bone density over a long period of time.

People with low bone density are susceptible to fracture and break from a fall due to bone weakening.

The exact causes of osteoporosis are unknown. However, researchers do know that certain preventable risk factors such as smoking, low calcium intake, physical inactivity, excessive alcohol consumption, and unpreventable risk factors such as aging, family history, gender, race, body frame size,... and sedentary works are associated to increase the onset of the disease.

Some researchers also suggested that loss of bone density due to age, medications used to treat breast cancer, arthritis, asthma, and certain chronic diseases such as Crohn's disease and Addison's disease and hyperthyroidism, hypopituaritism and eating disorders are also considered as some major risk factors of osteoporosis.

According to the statistic provided by the National Osteoporosis Foundation, over 10 million Americans are affected by osteoporosis and 34 million more have low bone mass, called osteopenia.

The most common symptoms of osteoporosis include back pain, as a result of a fractured or collapsed vertebra, loss of height, and a stooped posture.

Many patients with osteoporosis also experience symptoms of a bone fracture.

If you experience some of the symptoms above, you may have osteoporosis.

Conventional medicine such as Bisphosphonates: Fosamax, Actonel, Boniva, and Zoledronic Acid Bisphosphonates may be effective in reducing the risk of fracture, decelerating bone loss and ameliorating pain. However, they may induce some adverse effects, including impaired thinking, fainting, feeling light-headed, rapid heart rate,.... and gastrointestinal discomfort.

If you are taking one of those medicines, please make sure you discuss the side effects with your doctor.

Carrot, a root vegetable with an orange color is a sub spice of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.

In the reaffirm of the antioxidant activity in the protection of osteoporotic women, researchers at the University of Wisconsin (UW)-Madison launched an investigation of carotenoids in human serum effect of promotion of bone health among postmenopausal women.

In a total of 59 postmenopausal women participated, researchers found that
* Intake of carotenoids scores a significant effect of protecting the bone density, observed by the dual-energy x-ray absorptiometry, and osteoporosis diagnosis was based upon T-scores.

* Serum lycopene and beta-cryptoxanthin measured by 0.03 and 0.006, respectively in participants were correlated to the total intake of fruits and vegetables.

* However, serum alpha-carotene concentration was strongly associated with carrot intake.

Researchers, after taking into account other co and confounders suggested that carotenoid intake may have beneficial skeletal effects in women with osteoporosis.

Additionally, in vitro and in vivo studies suggest that carotenoids may have a strong protective effect of inhibited bone resorption, according to researchers at the Jean Mayer USDA HNRCA at Tufts University in differentiation of associations of total and individual carotenoid intake (alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, lutein + zeaxanthin) with incident hip fracture and nonvertebral osteoporotic fracture.

Furthermore, a total of 370 men and 576 women (mean age, 75 +/- 5 yr) from the Framingham Osteoporosis Study completed a food frequency questionnaire (FFQ) in 1988-1989 and followed for hip fracture until 2005 and nonvertebral fracture until 2003, researchers showed that


* Highest tertile of total carotenoid intake had a lower risk of hip fracture (p = 0.02).

* Higher lycopene intake had lower risk of hip fracture (p =0.01) and nonvertebral fracture (p = 0.02).

* However, total beta-carotene was associated with a weak protective trend for hip fracture alone, and NO significant associations were observed with alpha-carotene, beta-cryptoxanthin, or lutein + zeaxanthin.

These results suggested that only lycopene was found to have a clinical effect on the protection of bone health in all aspects compared to other bioactive compounds isolated from carrots.

And several members of carotenoids may play a protective role in bone health in older adults.

Moreover, in the reassessed the carotenoids bone protective effect in inhibited bone resorption and stimulate proliferation and differentiation of osteoblasts, in 334 men and 540 women (mean +/- SD age: 75 +/- 5 y) in the Framingham Osteoporosis Study, researchers at the Tufts University showed that intake of lycopene may protect the mean of bone density in both genders
* Carotenoid and lycopene intake exerted a 4-y change in lumbar spine BMD for women, and

* Total carotenoids, beta-carotene, lycopene, and lutein+zeaxanthin with 4-y change in trochanter BMD in men.

DR. Sahni S, the lead scientist said, "Carotenoids showed protective associations against 4-y loss in trochanter BMD in men and in the lumbar spine in women" and " These results support a protective role of carotenoids for BMD in older men and women".

Taken together, carrot and its bioactive compound lycopene may be considered as functional foods in reducing the risk of osteoporosis, including inhibited bone resorption and proliferation and differentiation of osteoblasts,... in both older men and women.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Serum carotenoid concentrations in postmenopausal women from the United States with and without osteoporosis by Yang Z1, Zhang Z, Penniston KL, Binkley N, Tanumihardjo SA. (PubMed)
(2) Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: a 17-year follow-up from the Framingham Osteoporosis Study by Sahni S1, Hannan MT, Blumberg J, Cupples LA, Kiel DP, Tucker KL.(PubMed)
(3) Inverse association of carotenoid intakes with 4-y change in bone mineral density in elderly men and women: the Framingham Osteoporosis Study by Sahni S1, Hannan MT, Blumberg J, Cupples LA, Kiel DP, Tucker KL.(PubMed)

#Herbal #Ashwagandha Inhibits #ProstateCancer through Immuno-modulation and Cell Cycle Arrest In Vitro

Kyle J. Norton

Cancer is a group of chronic diseases caused by irregular cell growth in the specific tissue of an organ due to DNA alternation.
Most cases of cancer start in the cell on the surface of the inner lining tissue before penetrating into deeper layers to form a tumor.

However, as cancer continued proliferation, at certain stages it can damage other healthy tissues. Sometimes cancer cells can spread to other organs in the body via lymph or blood.

Prostate cancer is a medical condition caused by the alternation of the cell on the surface of the inner lining of the prostate tissue.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

According to the statistic, approximately, 1 man in 9 will be diagnosed with prostate cancer during his lifetime and 6 cases in 10 are diagnosed in men aged 65 or older.

Prostate cancer shared common symptoms of an enlarged prostate, including frequent urination particularly at night, weak or interrupted urine flow and erectile dysfunction, blood in the urine, and blood in the seminal fluid.

The causes of prostate cancer are unknown. The increases with age, especially after age 50. family history. ethnicity, hereditary breast, and ovarian cancer (HBOC) syndrome, and genetic proposition are some prevalent factors found in patients with the condition.

Conventionally, treatments for prostate cancer are totally depending on the type, stage, and grade accompanied by the patient's overall health, age, and life expectancy.

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

Researchers on finding a potent and natural ingredient for the treatment of prostate cancer investigated the effects of Withania extracts on highly metastatic, androgen-independent prostate cancer cell line (PC3).

According to the results obtained from tested differentiation, the extracts demonstrated strong inhibitory activity in decreasing the cancer cell viability with a half-maximal inhibitory concentration (IC50) of 10 μg/mL.

The sample of prostate tissue and PC3 cells also exhibited the predominantly high expression levels of IL-8 associated with the production of chemokine produced by macrophages and COX-2 involved in the contribution of immune evasion and resistance to cancer immunotherapy was also suppressed by the lowest dose of W. somnifera in 24 hours.

Furthermore, the extract-induced cycle arrest of the cancer cell line at the cell cycle in the G2/M phase, was observed from the rapid accumulation of PC3 cells significantly.

Moreover, W. somnifera extracts suppressed the PC3 inherent metastatic activity.

Based on the results, researchers wrote, "W. somnifera may be a good therapeutic agent in addition to the existing drugs for PC".

Taken together, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of prostate cancer, pending the confirmation of a larger size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Drier Climatic Conditions Increase Withanolide Content of Withania coagulans Enhancing Its Inhibitory Potential Against Human Prostate Cancer Cells by Rehman S1, Keefover-Ring K2, Haq IU3, Dilshad E4, Khan MI5, Akhtar N6, Mirza B. (PubMed)
(2) Withania somnifera targets interleukin-8 and cyclooxygenase-2 in human prostate cancer progression by Setty Balakrishnan A1, Nathan AA1, Kumar M1, Ramamoorthy S2, Ramia Mothilal SK. (PubMed)

#Bilberry Modulates Gene Expression Against the Onset of #LungCancer, Scientists Say

Kyle J. Norton

Bilberry may have a strong effect in reducing the risk and treatment of lung cancer, according to studies.
Lung cancer is a chronic condition characterized by cell growth irregularly and disorderly in the lung tissue.

Most cases of lung cancer caused by the alternation of calls DNA begin in the cells on the surface of the inner lining of the lung.

At the advanced stage, the cancer cell from the lung can travel a distance away to infect other healthy tissue and organs through the circulation of fluid and blood, leading to secondary metastasis.

According to statistics, in 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Also in 2017, lung cancer caused the death of 21,100 Canadians.


Smoking although it is a major cause of lung cancer, however, not all lung cancer patients with lung cancer are smokers. Nonsmokers' lung cancer may be caused by exposure to radon, secondhand smoke, air pollution, or other factors.

Some researchers suggested that lung cancer in many incidences is associated with oxidative stress as found in advanced lung cancer patients.

Dr. the lead scientist in the examination of the oxidative stress in the risk lung cancer said, "Oxidative stress also plays important roles in the pathogenesis of many diseases, including aging, degenerative disease, and cancer. Among cancers, lung cancer is the leading cause of cancer in the Western world".

And, "Distinct measures of primary and secondary prevention have been investigated to reduce the risk of morbidity and mortality caused by lung cancer. Among them, it seems that physical activity and nutrition have some beneficial effects".

The results clearly suggested that the external sources of dietary antioxidants from the food sources may be helpful in reducing the risk of lung cancer by suppressing the overexpression of free radicals before they can induce oxidative stress.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a replacement for the treatment of lung cancer with no side effects examined the berries' bioactive compound anthocyanidins and its derivative cyanidin, malvidin, peonidin, petunidin, and delphinidin anticancer effects.

A mixture, including blueberry, bilberry and Indian blackberry ('Jamun') was selected to test in two aggressive non-small-cell lung cancer cell lines.

Injection of the mixture exerted a higher induction of cell-cycle arrest, apoptosis, and suppression of NSCLC cell invasion and migration compared to individual anthocyanidins.

According to tested assays, the mixture inhibited lung cancer cells apoptosis by decreasing the expression of the genes associated with cell cycle division and cell survival and proliferation.

Furthermore, the mixture also elevated the protein involved in cancer cell death programming.

Interestingly, in vivo, both the mixture of anthocyanidins from bilberry (0.5mg/mouse) and the most potent anthocyanidin, delphinidin (1.5mg/mouse) significantly inhibited the growth of H1299 xenografts in nude mice by 60%.

Dr. Kausar H and colleagues said, in the final report "Our results thus demonstrate the therapeutic potential of berries rich in this mixture of diverse anthocyanidins for non-small-cell lung cancer treatment and to prevent its future recurrence and metastasis".

In order to reveal more information about bilberry anti-lung cancer activity, researchers assessed the involvement of oxidative stress in lung adenocarcinogenesis, using mice deficient in the 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene and wild-type mice (C57BL6/J origin) administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Where deficiency of 8-hydroxyguanine DNA glycosylase 1 (Ogg1) gene was found to associate with the advanced stage of cancer.

On week after induced lung cancer by administered 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), selected mice were treated with one of 4 antioxidants (phenyl N-tert-butyl nitrone 0.13% in drinking water, resveratrol 20 ppm in the diet, lactoferrin 2% in diet and bilberry powder 2% in diet) or no supplement for 33 weeks.

All antioxidant applications demonstrated a strong inhibition against lung adenocarcinogenesis, through modulating the gene expression of gene deficiency such as 8-hydroxylamine DNA glycosylase 1 (Ogg1) and gene mutation such as Egfr and K-ras.


Taken altogether, bilberry processed abundantly bioactive compounds me be considered a functional remedy for the prevention and treatment of lung cancer, pending the confirmation of a large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells by Kausar H1, Jeyabalan J, Aqil F, Chabba D, Sidana J, Singh IP, Gupta RC. (PubMed)
(2) Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice by Igarashi M1, Watanabe M, Yoshida M, Sugaya K, Endo Y, Miyajima N, Abe M, Sugano S, Nakae D.(PubMed)
(3) Lung cancer: what are the links with oxidative stress, physical activity and nutrition by Filaire E1, Dupuis C, Galvaing G, Aubreton S, Laurent H, Richard R, Filaire M. (PubMed)