#Ginger Supplementation Inhibits Parameters Associated with the Risk of #MetabolicSyndrome, Scientists Say

Kyle J. Norton

Ginger may have a potential and profound effect in regulating the expression of metabolic syndrome, some scientists suggested.

Metabolic syndrome is a cluster of conditions associated with the onset of cardiovascular disease and diabetes, including fat around the waist, elevated blood pressure, high triglycerides, elevated blood sugar, and low HDL cholesterol.

Researchers suggested that people who have 3 of 5 above conditions are at substantial risk of heart disease, stroke, and type 2 diabetes.

There is no single cause of the metabolic syndrome. some conditions epidemiologically are associated with overweight or obese, insulin resistance, inactive lifestyle and poor diet.

According to the statistic, In the US, approximately, over 23 percent of adults have metabolic syndrome, many of them do not know they have it.

In fact, metabolic syndrome can be reversed through a healthy lifestyle choice, accompanied by weight loss.

Dr. Christos Pitsavos, the cardio team at the University of Athens and Society for Biomedical Diabetes Research, wrote, "Several epidemiologic studies and some clinical trials, it has been suggested that people with the metabolic syndrome may benefit from intensive lifestyle modifications including dietary changes and adopting a physically more active lifestyle."


"During the last decades increasing scientific evidence has emerged that protective health effects can be obtained from diets that are rich in fruits, vegetables, legumes, and whole grains, and which include fish, nuts, and low-fat dairy products".

These results clearly stated that by changing the poor diet pattern to a healthy one accompanied by moderate exercise, metabolic syndrome can be reserved.

Furthermore, a healthy lifestyle in patients with metabolic syndrome also greatly improved the reduction of body weight.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural ingredient or whole food for the treatment of metabolic syndrome, researchers assess the effects of ginger (Zingiber officinale Roscoe) on type 2 diabetes mellitus (T2DM) and/or components of the metabolic syndrome (MetS) by searching the database of medical literature.

10 studies met the inclusion criteria with a total of 490 individuals included in the review.

Ginger showed a significant beneficial effect on glucose control and insulin sensitivity.

Ginger significantly reduced fasting blood glucose in T2DM patients (-21.24; 95% CI: -33.21, -9.26; P < 0.001) and three-month average plasma glucose concentration.

Furthermore, ginger also displayed significant effects on the improvement of the lipid profile.

Dr. Zhu J, the lead scientist said, at the final report "Based on the negligible side effects and obvious ameliorative effects on glucose control, insulin sensitivity, and lipid profile, ginger may be a promising adjuvant therapy for T2DM and MetS".

Moreover, in order to gain more evidence of ginger's anti-metabolic syndrome effect, a study to determine the individual and concomitant effect of 6-week water-based exercise and oral ginger supplement on markers that have related to metabolic syndrome and systemic inflammation in obese women with breast neoplasms was conducted the University of Mazandaran.

40 women diagnosed with breast neoplasms were randomly assigned into four groups; placebo, exercise training, a ginger supplement, and exercise training+ ginger supplement groups.

Participants in the ginger supplement group and the exercise training+ ginger supplement group have orally received 4 capsules, 7 days a week and 6 weeks.

During the experiment, the ginger supplementation and the water-based exercise have resulted in a reduction of hs-CRP, IL-10 (inflammation), insulin, glucose, insulin resistance, low-density lipoprotein (LDL), triglyceride (TG); but an increase in high-density lipoprotein (HDL) and ratio HDL/LDL.

These results strongly suggested that ginger supplement plus exercise demonstrates a significant effect in reducing the fasting glucose, insulin resistance, inflammation, and lipid profile and balancing the ratio of high and low-density lipoproteins.


In other words, the water-based exercise and ginger supplement group significantly showed a larger positive effect on all outcomes, compared to the water-based exercise or ginger supplement alone groups.

The findings suggested that obese breast neoplasms survivors' metabolic syndrome and elevated inflammation were totally inhibited by the application of ginger supplement plus exercise training.

Taken together, ginger, the pungent spice can be considered a functional food for the prevention and treatment of metabolic syndrome accompanied by moderate exercise without inducing any adverse effects.


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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.


Sources
(1) Effects of Ginger (Zingiber officinale Roscoe) on Type 2 Diabetes Mellitus and Components of the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Zhu J1, Chen H1, Song Z1, Wang X1, Sun Z2. (PubMed)
(2) Individually and Combined Water-Based Exercise With Ginger Supplement, on Systemic Inflammation and Metabolic Syndrome Indices, Among the Obese Women With Breast Neoplasms by Karimi N1, Dabidi Roshan V1, Fathi Bayatiyani Z1. (PubMed)
(3) Diet, Exercise and Metabolic Syndrome by Christos Pitsavos,1 Demosthenes Panagiotakos,2 Michael Weinem,3 and Christodoulos Stefanadis. (PMC)

#Antioxidant #Alliin Inhibits Proteins and Genes involved Diseases Associated with the Production of Pro-Inflammatory Cytokines

Kyle J. Norton

Inflammation is a natural defense of the immune system that protects the body against the invasion of harmful stimuli and pathogens.

In the acute phase of infection, the immune first line of defense white blood cells, macrophages stimulates the production of proinflammatory cytokines with an aim to destroy all invaders which try to enter the body.

Most cases of acute infection are stopped at this phase and the wound is healed itself quickly.

However, if the wound is too large, then the recovery may take a longer period of time and through 4 overlap recovery stages.

Any interruption in the overlapped recovery stage may cause the formation of scars, similar to those of overproduction of pro-inflammatory cytokines.

Diseases associated with chronic inflammation induced by protein, lipid, and cellular damage include cardiovascular disease, diabetes, neurodegenerative disease,... and cancers.

In other words, prolonged low-grade inflammation caused by continuing the production of pro-inflammatory cytokines due to an immune response that can not kill off all invaders in a set period between 3-8 weeks can result in serious and chronic diseases.

The results have been found to cause cell death and alternation of cell DNA.

Believe it or not, people with low-grade chronic inflammation are prone to psychological stress that links to a greater risk for depression, and heart disease. particularly the body's ability to regulate the inflammatory response and normal defense.

Out of many risk factors involved in the onset of chronic inflammatory diseases, some researchers suggested the promotion of a high-fat diet in the Western world may correlate to the rise of the condition.

Dr. Yehui Duan, the lead scientist wrote, "In recent years, chronic overnutrition, such as consumption of a high-fat diet (HFD), has been increasingly viewed as a significant modifiable risk factor for diseases such as diabetes and certain types of cancer".

And, "the recent scientific literature about HFD-induced inflammation and subsequent development of diseases and cancer, with an emphasis on mechanisms involved. Given the expanding global epidemic of excessive HFD intake, understanding the impacts of an HFD on these medical conditions, gaining great insights into possible underlying mechanisms, and developing effective therapeutic strategies are of great importance".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

In the urgency to find a natural and potential compound for the treatment of diseases associated with inflammation, researchers examined the active component is alliin (S-allyl cysteine sulfoxide) anti-inflammatory activity.

Before incubated with alliin, lipopolysaccharide- (LPS-) stimulated 3T3-L1 adipocytes showed a significant increase in proteins involved in the production of pro-inflammatory cytokines, including IL-6, MCP-1, and Egr-1 in 3T3-L1 adipocytes exposed to 100 ng/mL LPS for 1 hour.

According to the tested assay in lipopolysaccharide- (LPS-) stimulated 3T3-L1 adipocytes incubated for 24 h with 100 μmol/L alliin, the bioactive compound inhibited such increase.


Furthermore, the overexpression of the phosphorylation of ERK1/2 associated with cell differentiation including cell death caused by LPS-induced inflammation in adipocytes was also decreased following alliin treatment.

Additionally, alliin prevented the expression of inflammation in facilitating the alternation of cell DNA by modulating the gene expressions involved in immune response such as tumor-suppressive genes and inhibiting the genes related to cancer.

Dr. Saray Quintero-Fabián, the lead scientist wrote, " The present results have shown that alliin is able to suppress the LPS inflammatory signals by generating an anti-inflammatory gene expression profile and by modifying adipocyte metabolic profile".


Taken altogether, alliin may be considered supplements for the prevention and treatment of diseases associated with inflammation, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Alliin, a Garlic (Allium sativum) Compound, Prevents LPS-Induced Inflammation in 3T3-L1 Adipocytes by Saray Quintero-Fabián,1,2 Daniel Ortuño-Sahagún,1 Manuel Vázquez-Carrera,3 and Rocío Ivette López-Roa. (Hindawi)
(2) Inflammatory Links Between High Fat Diets and Diseases by Yehui Duan,1,† Liming Zeng,2,† Changbing Zheng,3 Bo Song,3 Fengna Li,1 Xiangfeng Kong,1and Kang Xu. (PMC)

#NavyBean Inhibits #Genes and #Proteins Associated with Acute-Inflammative Diseases in Vivo, According to Studies

Kyle J. Norton

Inflammation is a natural response by the immune system to protect the body against the invasion of stimuli or foreign pathogens.

Acute inflammation is a short-term condition caused by tissue injury, leading to pain, redness, swelling, and heat in the affected area. depending on the size of the injury. Some patients with acute inflammation may also experience the symptom of loss of function.

In acute inflammation, the white blood cells on the first line of defense of the immune system after sensing the danger of an infection in the body through a message from the brain stimulate the production of platelets to cover the site of injury or damage and inflammatory cytokines to kill off all pathogens before they can cause harm to the body.

Most cases of infection are stopped at the acute phase. The wound or injury is slowly recovered.

However, in people with a weakened immune system, acute inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, which may lead to low-grade chronic inflammation.

Anti-inflammation is the process that inhibits inflammation or swelling without affecting the immune property to curb foreign pathogens.

Conventionally, the most common use of anti-inflammatory medicines is over counter aspirin, ibuprofen (Advil, Motrin, Nuprin), and other prescription NSAIDs.
Holistically, according to the Medical University Innsbruck, the top 5 anti-inflammatory foods are
* Garlic
Recent studies also showed that garlic exhibits anti-inflammatory effects against chronic inflammatory disease through phytochemical allicin and other mechanisms.

* Ginger
Strong evidence in Western studies suggested that ginger processes anti-inflammatory, antioxidant and immune-modulatory effects.

* Turmeric
Epidemiological studies also found the efficacy of turmeric for the treatment of diabetes, microbial infection gastrointestinal diseases, and irregular cell growth such as cancer through its anti-inflammatory antioxidant and immunomodulatory activities.

* Green tea
Epidemiological studies suggested that green tea consists of many pharmaceutical properties, including anti-cancer, anti-diabetes, anti-allergy, and anti-micro-organisms infection, through its antioxidant, anti-inflammatory and immune-modulatory activities.

* Shiitake mushrooms
Recent studies showed that Shiitake mushrooms process the properties of anti-cancer, anti-HIV, and hepatitis virus, an enhanced immune system against inflammation.

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.

With an aim to find a potential ingredient for diseases associated with acute inflammation, researchers examined the enriched levels of nondigestible fermentable carbohydrates and phenolic compounds found in black and navy beans' immunomodulatory effects on the severity of colitis-associated inflammatory pathology.

In an animal model, C57Bl/6 mice were pre-fed isocaloric 20% cooked navy bean (NB) or black bean (BB) diets for 3 weeks and switched to control basal diet (BD) 24 h prior to colitis induction via 5-day exposure to dextran sodium sulfate (2% w/v in drinking water)+3 days of freshwater, researchers found that* The severity of the acute colitis phenotype associated with inflammation was inhibited by bean prefeeding, observed by reduced colon tissue inflammatory transcription factor activation such as NFκB, STAT3) and inflammatory mediator levels such as IL-1β, IL-6, IL-18, and MCP-1 compared to control.

* Black and navy beans also stimulated the biomarkers that enhance wound repair responses. including colon tissue protein levels of IL-22, and IL-27.

* Furthermore, the black and navy beans diet also increases the mRNA expressions of genes involved in the normal colonic epithelial function and the promotion of epithelial barrier integrity, defense and/or restitution, and wound closure in acute colonic inflammation.

Based on the findings, researchers concluded, " bean supplementation prior to colitis induction (i.e., mimicking disease relapse) primes the colonic microenvironment to attenuate the severity of the colitis inflammatory phenotype and maintain aspects of epithelial barrier function".

Taken together, the navy bean may be considered a remedy for the prevention and treatment of acute inflammation, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) (1) Navy and black bean supplementation attenuates colitis-associated inflammation and colonic epithelial damage by Monk JM1, Wu W2, Hutchinson AL3, Pauls P4, Robinson LE3, Power KA. (PMC)
(2) Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis by Zhang C1, Monk JM1, Lu JT1, Zarepoor L1, Wu W1, Liu R1, Pauls KP2, Wood GA3, Robinson L4, Tsao R1, Power KA. (PubMed)

#Phytochemical #Sinigrin Induces Genotoxicity and Proliferation Against #Cancer Cells, According to Studies

Kyle J. Norton

Sinigrin may be used as a natural and bioactive compound for killing cancer cells before they can spread, according to studies.
Cancer is a group of diseases characterized by cell growth irregularly in the tissue of the body, including glands and organs due to the alternation of cell DNA.

In normal cells, through the process of mitosis, new cells are born through the division of one cell into two with an aim to replace cells that have been lost, damaged, or worn out. The cell division cycle is closely regulated and they can give rise to only a limited array of cells.

The characteristics of cancer cell growth are completely different compared to normal cells. The cancer cell can divide indefinitely; They are out of control by the immune system. They don't follow the signals of stop division,.... and they do not have a specific function.


How cancer grows? Most cancers stimulate the production of a new blood vessel for nutrition and the function of producing enzymes that break down normal cells and tissues.

All cancers share the general symptoms of unintended weight loss, loss of appetite, fatigue, tiredness, and gastrointestinal discomforts accompanied by specific symptoms depending on the location of the cancer or the organ that was affected.

Out of a number of risk factors, some researchers suggested the creation of obesity in the modern world may be one of the major risk factors associated with the incidence.

Dr. Nathan A. Berger in the evaluation of obesity and risk of cancer wrote, "Overweight and obesity have reached pandemic levels on a worldwide basis and are associated with increased risk and a worse prognosis for many but not all malignancies".


And, " lessons learned from the use of murine models to study the association, the impact of obesity on pancreatic cancer, the effect of dietary fats and cholesterol as cancer promoters, and the mechanisms by which the intestinal microbiome affects obesity and cancer".

The results showed a relationship between the unhealthy diet risk of obesity in the induction of cancer.

Sinigrin is a phytochemical glucosinolate, that belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Researchers on finding a natural compound for the treatment of cancers examined sinigrin, the bioactive ingredient in cruciferous vegetables for their health benefits and cancer prevention properties in vitro against HL60 (human promyelocytic leukemia cell line) systems.


According to the HL60 assays, sinigrin showed the tumoricidal activity of plant samples (IC50 = 0.28 mg·mL(-1)) by breaking down the products of sinigrin hydrolysis.

Sinigrin also exerted a significant effect in the induction of tumor genotoxicity and proliferation causing harm to the nearby healthy cells.

The finding strongly suggested that the efficacy of cruciferous vegetables in inducing cancer cell death and proliferation was attributed to the presence of the bioactive ingredient sinigrin.

Furthermore, in a model of carcinogen-induced hepatotoxicity in rats, injection of sinigrin significantly inhibited the proliferation of liver tumor cells without inducing liver toxicity.

Injection of the compound for a period of 3 months exhibited pro-apoptotic activity against liver cancer by activating the tumor-suppressive gene in the rats.

The active bioactive compound also inhibited cancer cell proliferation by deactivating the production of proteins associated with liver cancer cell differentiation.

The effect of sinigrin against liver cancer is also found to cancer cell cycle arrest in the G0/G1 phase.

The results clearly suggest that sinigrin processes important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats.

Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the prevention and treatment of cancer, pending to the confirmation of a large sample size and multicenter human study.


However, intake of bioactive in the form of supplements should be taken with extreme care, as liver toxicity may be induced if overdosed.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antigenotoxicity and Tumor Growing Inhibition by Leafy Brassica carinata and Sinigrin by Lozano-Baena MD1, Tasset I2, Obregón-Cano S3, de Haro-Bailon A4, Muñoz-Serrano A5, Alonso-Moraga Á. (PubMed)
(2) Anti-proliferative activities of sinigrin on carcinogen-induced hepatotoxicity in rats by Jie M1, Cheung WM1, Yu V1, Zhou Y1, Tong PH1, Ho JW. (PubMed)
(3) Obesity and cancer pathogenesis by Nathan A. Berger. (PMC)

#Cranberry Supplementation Reduces Aβ toxicity induced Brain Cell Stress Agaisnt the Onset of #Alzheimer's disease, Reseracher Say

Kyle J. Norton

Amyloid beta (Aβ or Abeta) is the main component of the amyloid plaques that cause the gradual death of neurons, leading to the onset of Alzheimer's disease.
Alzheimer's disease is a common form of dementia or neurodegenerative disease found in the elderly.

Alzheimer's disease is a type of dementia correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.

According to the statistics, the disease is most prevalent in the elderly. Approximately 5.7 million Americans of all ages are living with Alzheimer's. 15.9 million family caregivers provide an estimated 18.2 billion hours and $230 billion to people with dementia worldwide.

Alzheimer's disease is caused by a combination of genetic, lifestyle and environmental factors that affect the neurons of the brain over time. However, less than 10% of patients with AD are associated with a genetic preposition. Patients with such mutated genes on chromosomes 21, 14, and 1are virtually guaranteed to develop the disease.

More precisely, Alzheimer's disease is caused by the gradual loss of neuron functioning that usually starts with the early symptom of the difficulty of remembering recent events and worsens over time.

Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia.

Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of mental disorders, researchers examined the effect of cranberry supplementation on β-amyloid aggregation.

According to tested analysis, the cranberry protected the neurons by mediating Aβ toxicity alleviation required heat shock transcription factor (HSF)-1 rather than DAF-16 and SKN-1 associated with cellular stress.

In other words, cranberry supplementation reduced Aβ toxicity induced brain cell stress by reducing the transactivity of HSF-1 in an IIS-dependent manner.

More precisely, HSF-1 plays a pivotal role in maintaining proteostasis, a process that regulates proteins within the cell in order to maintain the neuron cellular health involved in oxidative stress.

Based on the findings, researchers aid, "(cranberry) elucidated the mechanism whereby cranberry attenuated Aβ toxicity in C elegans and stressed the significance of proteostasis in the prevention of age-related diseases from a practical point of view.".

Taken altogether, cranberry may be considered a remedy for the treatment of AD, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberry Extract Standardized for Proanthocyanidins Alleviates β-Amyloid Peptide Toxicity by Improving Proteostasis Through HSF-1 in Caenorhabditis elegans Model of Alzheimer’s Disease by
Hong Guo, Min Cao, Sige Zou, 4 Boping Ye, and Yuqing Dong. (PMC)

#Phytochemical #Alliin Supplement Exhibits Neuro-Protection through Antioxidant Effects in Vitro, According to Researchers

Kyle J. Norton

Neuroprotection is an action induced by the preservation of neuronal structure and/or function, including the use of medicines and herbs.

In other words, neuroprotection protects neuronal integrity against the reduction in the rate of neuronal loss over time, particularly in neurodegenerative diseases.

Neurodegenerative disease is the class of conditions associated with the progressive loss of neurons occurred mostly in older adults, including dementia, with the most common being Alzheimer`s disease (AD).

According to the statistic, dementia affects over 47.5 million people worldwide, approximately 58 percent are living in low and middle-income countries.

Believe it or not, 5.8 million Americans of all ages are living with Alzheimer's dementia in 2019 and two-thirds of people with Alzheimer's disease are women.

Conventionally, there is no cure for dementia. The purpose of the medications that are used for the treatment of dementia is to improve dementia symptoms and slow down the progression of the disease.

Some researchers are concern that Alzheimer's disease in people younger than the age of 60 was up 5 percent over the past few decades may be correlated to the promotion of a high-fat diet in the US.

Dr. Ruan Y, the lead scientist wrote, "A higher dietary saturated fat intake was significantly associated with an increased risk of 39% and 105% for AD (RR: 1.39; 95% CI: 1.00, 1.94) and dementia (RR: 2.05; 95% CI: 1.06, 3.98), respectively".

And, "Dose-response analysis indicated a 4 g/day increment of saturated fat intake was related to 15% higher risk of AD (RR: 1.15; 95% CI: 1.01, 1.31)".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

In the urgency to discover a natural and potential compound for the treatment of neurodegenerative disease, scientists examined the alliin neuroprotective activity.

In vitro, alliin exerted a significant effect to protect neuronal cell integrity and viability against beta-amyloid (A) toxicity and apoptosis.

Furthermore, also in vitro, alliin inhibited oxidative stress caused by overexpression of reactive oxygen species (ROS) in cells in facilitating several neurodegenerative diseases including Alzheimer's disease (AD).

In lipopolysaccharide- (LPS-) stimulated 3T3-L1 used in biological research on adipose tissue, incubation in a period of 24 h together with 100 μmol/L alliin, alliin prevented the increase of proinflammatory cytokines in the liver, muscle, heart, and brain cells through its antioxidant activity.

The inhibition of inflammation of alliin was attributed to the decreased expression of the ERK1/2 pathway involved in the expression of oxidative stress and inflammation.

In other words, alliin protects the brain cells by suppressing the LPS inflammatory signals by generating an anti-inflammatory gene expression.

Taken together, alliin may be considered a supplement for neuroprotection, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Neuroprotective Effects of Garlic A Review by BC Mathew and RS Biju. (PubMed)
(2) Alliin, a garlic (Allium sativum) compound, prevents LPS-induced inflammation in 3T3-L1 adipocytes by Quintero-Fabián S1, Ortuño-Sahagún D2, Vázquez-Carrera M3, López-Roa RI. (PubMed)
(3) Dietary Fat Intake and Risk of Alzheimer's Disease and Dementia: A Meta-Analysis of Cohort Studies by bRuan Y1, Tang J1, Guo X1, Li K2, Li D. (PubMed)

#Healthyfood #BlackBeans Exhibit Anti-Proliferative Activity Against Cancers through Their Antioxidant Effects, Researchers Suggest

Kyle J. Norton

Intake of black(common) beans and other common beans may associate with reduced risk and treatment of various types of cancers, a study of renowned institute study suggested.

Cancer is a class of chronic conditions characterized by irregular cell growth in the body's organs. Sometimes, the cancer cells can spread to other tissues or organs depending on the stages of cancer.


Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that the black bean was the first domesticated growth in South America.

Fermentation products of soybean, black bean, and green bean mixture (BN999), showed a significant effect in inhibiting the growth of human breast cancer AU565 cells and prostate adenocarcinoma PC-3 cells without harming the normal human cells.

The study also found that in syngenic BALB/c mice, the mixture(BN999) inhibited the growth of mouse CT-26 colon cancer xenografts, without causing adverse effects.

Furthermore, BN999, also induced cancer cell death in other mechanisms, such as activating the protein gene involved in pro-cancer cell apoptosis via cell mediatory activities, including a network of membranous anatomical structure and double membrane-bound organelle.in energy conversion.


Additionally, according to the joint study led by the Universidad Autónoma de Querétaro, the efficacy of common bean in attenuated cancer risk factors is shown in animal models and in cell cultures. may also be attributed to other parameters of non-digested compounds like fiber, phenolics, peptides, and phytochemicals.

In fact, black (common) bean whole and non-digestible fraction also exhibited anti-proliferative activity and induced apoptosis in vitro and in vivo against colon cancer.

Dr. Rocio Campos-Vega lead author in the joint study also raised the important role of bean fiber and protein of the bean in ameliorated cancer risks, saying, " the potential health benefits and bioactivity of beans on tumor inhibition, highlighting studies involving functional compounds, mainly non-digestible fractions that modulate genes and proteins, thereby, unraveling their preventive role against the development of cancer".

Other researchers in the evaluation of phytochemicals of black beans against various types of cancers showed that flavonoids and saponins isolated from black beans exerted a strong antioxidant capacity and antiproliferative activity against numbers of cancer cell lines in a concentration-dependent manner.

The study also insisted that depending on days of germination, total phenolic content extracted from seed coats at the 3 days exhibited the strongest effect in inhibiting all cancer cell lines proliferation with no cytotoxicity against control cells.

Specifically, the chemical compound genistein showed the most effectiveness against mammary cancer cells compared to more related to hepatic and colon cancers in flavonols and saponins.

The findings suggested that black beans may be considered a functional food as well as an integrated form of injection for reduced risk and treatment of various types of malignant tumors



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Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Common Beans and Their Non-Digestible Fraction: Cancer Inhibitory Activity—An Overview by Rocio Campos-Vega,1,* B Dave Oomah,2,† Guadalupe Loarca-Piña,1,† and Haydé Azeneth Vergara-Castañeda3(PMC)
(2) Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells by Chia JS1, Du JL, Wu MS, Hsu WB, Chiang CP, Sun A, Lu JJ, Wang WB.(PubMed)
(3) Evaluation of the antioxidant and antiproliferative activities of extracted saponins and flavonols from germinated black beans (Phaseolus vulgaris L.) by Guajardo-Flores D1, Serna-Saldívar SO, Gutiérrez-Uribe JA. (PubMed)