#Betacyanins Found in #Beetroot Induce #BladderCancer Cell Apoptosis with Cell Death Programming

Kyle J. Norton

Cancer is a group of medical and chronic conditions characterized by irregular cell growth in the tissue of a specific organ in the body.

Most cases of cancer start in the cell on the surface of the inner lining tissue of an organ. After penetrating deeper layers and colonizing the entire organ, the cancerous cells can spread to the healthy tissue of other organs through lymph and blood.

The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.

Bladder cancer occurs when cell mass in the inner lining of the bladder forms a malignant growth or tumor. Bladder cancer developed in the bladder lining has also been found to spread through the bladder wall to nearby organs such as the prostate gland in men or the uterus in women.

Bladder cancer can be classified depending on its proliferation
* Superficial types of bladder cancer
The most recurrent type of bladder cancer has a characteristic of noninvasive. These types of bladder cancer can be controlled or removed by regular cystoscopy.

* Invasive types of bladder cancer
Invasive types of bladder cancer tend to spread after beginning in cells in the lining of the bladder. These types of cancer often require surgery by removing part or the whole bladder.

The exact causes of bladder cancer are not identified. However, smoking has been found to induce a substantial risk of bladder cancer incidence.

Dr. Neal D Freedman, the lead scientist wrote, "...the population attributable risk of bladder cancer for tobacco smoking is 50–65% in men and 20–30% in women and that current cigarette smoking triples bladder cancer risk relative to never smoking".


And, "Compared to a pooled estimate of US data from cohorts initiated between 1963 and 1987, relative risks for smoking in the more recent NIH-AARP cohort were higher, with population attributable risks for women compared to those for men".

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

In finding a natural pigment for the prevention and treatment of cancer, researchers examined Betacyanins (BC) purified from beetroot (Beta vulgaris var. Rubra L.) tested, alone or in combination with vitexin-2-O-xyloside (XVX) from Beta vulgaris var. cicla L. in the proliferation rate in T24 bladder cancer cells.

According to the tested analysis,* Combination of BC and XVX exhibited a synergistic effect that inhibits proliferation in T24 cancer cells at 24 and 48 h but not after 72 h of incubation.

* The combination-induced apoptosis of T24 bladder cancer cells was observed by means of fluorescence-activated cell sorting (FACS) analysis by increasing the expression in caspases associated with cell death programming.

The inhibition of the bladder cancer cell line was found to enhance the expression levels of the pro-apoptotic gene and inhibit anti-apoptotic and survival proteins.

Extrinsically, the administration of BC increased the activity of caspase 8, a protein associated with the induction of apoptosis.

Interestingly, the XVX, BC, and their combination induced cancer cell death without exhibiting a cytotoxic effect on normal and healthy human cells.

Based on the findings, Dr. Scarpa ES, the lead scientist said, "the efficacy and the mechanisms of the action of BC and XVX, extracted from edible plants, and suggested that a diet or a nutrition supplement, enriched with these bioactive molecules, could be used in the prevention of human bladder cancer".

Taken together, betacyanins may be considered a remedy for the prevention and treatment of bladder cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES. (PubMed)
(2) Betacyanins enhance vitexin-2-O-xyloside mediated inhibition of proliferation of T24 bladder cancer cells by Scarpa ES1, Emanuelli M2, Frati A1, Pozzi V2, Antonini E1, Diamantini G1, Di Ruscio G3, Sartini D3, Armeni T3, Palma F1, Ninfali P. (PubMed)
(3) Bladder Cancer by Kyle J, Norton
(4) Association between smoking and risk of bladder cancer among men and women by Neal D Freedman, Ph.D., MPH,1 Debra T Silverman, ScD, ScM,1 Albert R Hollenbeck, Ph.D.,2Arthur Schatzkin, MD, DrPH,1 and Christian C Abnet, Ph.D., MPH. (PMC)

#NavyBeans Inhibit Lipid Parameters Associated with An Increased Risk of High Blood Cholesterol, Researchers Show

Kyle J. Norton

Cholesterol is a way substance produced by the liver or from food sources that plays an important role to build strong cell membranes and producing steroid hormone and vitamin D and aiding the digestive tract in absorbing the nutrients for our body needs.

Hyperlipidemia is also one of the conditions found in the cluster of metabolic syndrome.


In a healthy individual, excess cholesterol is returned to the liver after performing the aforementioned function by high-density lipoprotein or "good cholesterol".

However, a prolonged period of overexpression of abnormal blood cholesterol due to excessive consumption of fat or reduced levels of "good cholesterol" in the bloodstream can cause plaque building up on the arterial wall, leading to heart disease and stroke.

Depending on the choice of diet, your risk of high blood cholesterol can be increased or decreased.


The healthy ratio of blood cholesterol is 4 (low-density lipoprotein) to 1 (high-density lipoprotein).

If your ratio is lower than 4, you are considered to have a healthy blood-cholesterol ratio.


Hyperlipidemia is preventable. If you have high blood cholesterol, reducing bad fat intake accompanied by an increased intake of "good cholesterol" with moderate exercise can be helpful.


More precisely, by changing to a healthy diet and lifestyle with moderate exercise, you are at a lower risk of high blood cholesterol sometimes in the future (weeks or months, depending on the levels of blood cholesterol today).


People who follow the Western diet with a high in saturated and trans fat, red meat, processed food and low in fruits and vegetables and whole grains may have a substantially increased risk of abnormally high blood cholesterol.

According to the article "Western Diet and Heart Risk", the author wrote, "Western diets cause a third of heart attack deaths worldwide,” the Daily Mail reports. Western-style diets high in meat, fat, dairy, and salt put people at higher risk of a heart attack. According to the newspaper, a study has found that poor diet is responsible for 30% of the risk of heart disease".

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.

In finding a dietary source for the treatment of high blood cholesterol, researchers examined whether cooked navy bean powder (NBP) and/or heat-stabilized rice bran (RB) supplementation is tolerable, improves dietary fiber intake in children, and modulates lipid profiles.

The study included children aged 8 to 13 years at risk for CVD due to abnormal lipids. In other words, all participants were diagnosed with elevated cholesterol levels including total cholesterol ≥180 mg/dL and high-density lipoprotein (HDL) <60 mg/dL; low-density lipoprotein (LDL) ≥100 mg/dL and HDL <60 mg/dL; or non-HDL >100 mg/dL and HDL <60 mg/dL.


Participants received muffins or a smoothie daily that included 0 g NBP or RB (control), 17.5 g NBP, 15 g RB, or a combination of 9 g NBP + 8 g RB. Fasting blood was collected at baseline and week 4.

Only 38 children completed the trial, including n = 9 control, n = 10 NBP, n = 9 RB, and n = 10 NBP + RB groups.

Additionally, participants in the intervention groups significantly increased intake of NBP and RB at week 4 (p≤.01), particularly increased fibers in NBP and NBP + RB groups from baseline to week 4.

Based on the tested assays, HDL-cholesterol was higher in NBP-group participants compared to the control at week 4.

Although other lipid parameters also showed signs of decreasing, they are insignificantly due to the
shorter duration of the experiment (4 weeks).


In other words, higher daily intakes are needed for a longer duration to induce favorable changes across multiple serum lipid parameters.

Taken together, navy bean may be considered a remedy for the prevention and treatment of high blood cholesterol, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Pilot Randomized Controlled Clinical Trial to Assess Tolerance and Efficacy of Navy Bean and Rice Bran Supplementation for Lowering Cholesterol in Children by Borresen EC1, Jenkins-Puccetti N2, Schmitz K1, Brown DG1, Pollack A2, Fairbanks A1, Wdowik M1, Rao S1, Nelson TL1, Luckasen G3, Ryan EP. (PubMed)
(2) Western diet and heart risk, Tuesday, October 21, 2008, by NHS

#Indicaxanthin Inhibits Pathways Associated wuth the Proliferation of the #Melanoma Cells in Vitro, According to Studies

Kyle J. Norton

The skin is the largest external organ that protects us against infection and physical trauma by guarding the underlying muscles, bones, ligaments, and internal organs.

Furthermore, the skin accompanied by liver and kidney detoxes toxins in the body
Melanoma is a type of skin cancer caused by the alternation of cell DNA in the pigment-containing cells known as melanocytes. Most cases of melanomas are found in the skin.

According to the statistics, approximately 120,000 new cases of melanoma in the US are diagnosed in a year. Skin cancer tends to spread along the skin in most cases, but also can grow down to the deeper layers of the skin.

At the advanced stage, skin melanoma can also travel a distance away to infect other healthy tissues through blood and fluid circulation.

Most common symptoms of melanoma skin cancer are
* Asymmetry
The mole on the skin is no longer symmetric as one half of the mole is different from the other half.

* Borders irregular
The border of the mole has become irregular, such as uneven or notched.

* Color
The color of the mole is different than other moles on the skin.

* Diameter
The mole is larger than other moles and evolved over time
Accompanied by pain, swelling, and bleeding in the affected skin

There are 3 main types of melanoma skin cancer, including
* Superficial spreading
This is the most common type of melanoma, accounting for over 70% of all cases. The cancer cell usually starts with a normal mole, but for whatever reason, it begins to change malignantly with irregular borders and color variations.

* Nodular type
This type of melanoma is more aggressive growth than superficial spreading and found most on the trunk, upper arms, and thighs. The nodular type of melanoma is usually detected as a lump with blue and black color.

* Acral melanoma
Acral melanoma is mostly founded on the hands, feet, and nail beds. The risk increases for people with darken-skin color.

* Lentigo malignant melanoma
Found mostly on the face of the elderly caused by great exposure to sunlight.

Indicaxanthin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

With an aim to find a potent ingredient for the treatment of cancer, researchers investigated the effects of Indicaxanthin, against human melanoma both in vitro and in vivo.

According to the tested analysis, the growth of A375 cells was inhibited by the injection of the phytochemical

Furthermore, Indicaxanthin also induced apoptosis and decreased the invasiveness of A375 cells.

In other words, indicaxanthin effectively inhibits the proliferation of highly metastatic and invasive, and anti-apoptotic activity of the A375 cells.

In mice, induced melanoma, oral administration of Indicaxanthin also significantly reduced tumor development.

In additional differentiation of the anti-cancer activity of Indicaxanthin, researchers found that the efficacy of the bioactive compound was attributed to the inhibition of the NF-κB pathways associated with the antiproliferative effect of indicaxanthin.

Based on the results, researchers wrote, " indicaxanthin represents a novel phytochemical able to significantly inhibit human melanoma cell proliferation in vitro and to impair tumor progression in vivo".

Taken together, indicaxanthin may be considered a remedy for the prevention and treatment of melanoma, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Indicaxanthin from Opuntia Ficus Indica (L. Mill) impairs melanoma cell proliferation, invasiveness, and tumor progression by Allegra M1, De Cicco P2, Ercolano G2, Attanzio A1, Busà R1, Cirino G2, Tesoriere L1, Livrea MA1, Ianaro A. (PubMed)
(2) Melanoma Skin Cancer (Malignant Melanoma) by Kyle J. Norton

#BeetRoot Shows a Significant Cytotoxicity in Decreased the Growth Rate of #ProstateCancer Cells, Researchers Say

Kyle J. Norton

Prostate Cancer is a medical condition characterized by irregular cell growth and multiplied disorderly in the prostate tissues.
Beet, best known as the beetroot or garden beet, belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

Red beetroot (Beta vulgaris L.) may have a profound effect in reduced risk and treatment of prostate cancer, some studies suggested.

According to the Howard University, red beetroot (Beta vulgaris L.) extract (B), approved by Food and Drug Administration and European Union, in drinking water may be safe and used as cancer chemopreventive effect in humans.

Intake of the extract showed a significant effect in reduced synergistic antiproliferative activity against prostate (PC-3) tumor cells of human origin.

When combined anticancer drug doxorubicin (D), the combination acted synergistically in the expression of cytotoxicity against prostate cancer at a ratio of 1:5.

In a total of 24 patients (mean age 68+/-8 years) with hormone-resistant and metastatic prostate cancer treated with taxan chemotherapy, given twice 10 g daily for 1 month of natural table beet products come from commercial service, intake of beet juice showed a significant effect in control of the progression of prostate cancer in promoted life expectancy and reduced toxicity side effect induced by conventional chemo-drug.

The efficacy may be contributed by the mediated activities of phytochemicals in the juice in the inhibition of inflammation through the expression of the production of antioxidants.

The study also suggested that moderate and permanent consumption of table beet products may favorably affect the life expectancy of prostate cancer patients.

Furthermore, in the testing extract of red beetroot (Beta vulgaris L.), the FDA-approved red food color E162, against various cancer cell lines, researchers at Howard University found that the extract showed significant cytotoxicity in decreased the growth rate of the PC-3 cells, although lesser in compared to doxorubicin, a chemo medicine( (8.6% vs. 100%, respectively, at 29 µg/ml concentration of each, three-day test period).

The study also suggested that betanin, the major betacyanin constituent found in beetroot, may be phytochemicals responsible for the cytotoxicity.


These findings showed that beetroot may be used as a functional food to a reduced risk of early-onset and treatment of prostate cancer. And reduced adverse toxicity when used in combination with chemo drugs.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines by Kapadia GJ1, Rao GS, Ramachandran C, Iida A, Suzuki N, Tokuda H.(PubMed)
(2) [Effects of bioactive molecules of Beta vulgaris L. ssp. esculenta var. rubra on metastatic prostate cancer].[Article in Hungarian]by Nyirády P1, Sárdi E, Beko G, Szucs M, Horváth A, Székely E, Szentmihályi K, Romics I, Blázovics A.(PubMed)
(3) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H.(PubMed)

#Andrographis Inhibits Pathways and Metastasis Associated with an Increased Risk of #BreastCancer

Kyle J. Norton

Herbal Andrographis paniculata may be used as a therapeutic agent for treatment and drug resistance to breast cancer, a study by the renowned institute suggested.

Andrographis paniculata also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, and upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...

Breast cancer (malignant breast neoplasm) is a condition characterized by abnormal cells growing in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).


In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

According to the joint study led by the University of Kalyani, Andrographolide showed significant inhibition of MDA-MB-231 breast cancer cell proliferation in a time- and concentration-dependent manner.

The study also found that the inhibition of breast cancer cell line proliferation with no effect on normal breast epithelial cells, through reduced oxygen species (ROS) production and increased the population of apoptotic cells.

Others, in the study of the cytotoxic effect of a chemical compound, 14-Deoxy-11,12-didehydroandrographolide (14-DDA), a major diterpenoid isolated from Andrographis paniculata (Burm.f.) Nees, application of the products suppressed the T-47D breast carcinoma cells caused cytotoxicity, and elicited a non-apoptotic cell death.

Also in the MDA-MB-231 breast cancer cell, Andrographolide, a major chemical compound found in Andrographis exhibited strong anti-breast cancer cell growth activities in regulating breast cancer cell proliferation, survival and progression, and breast cancer metastasis through various mechanisms involving pro-inflammatory pathways.

Taking together, there is no doubt that Andrographis may be used as a possible chemopreventive and chemotherapeutic agent for human breast cancers, But a large amount of intake should only be prescribed by an herbalist.



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Cytotoxicity and cell cycle arrest induced by andrographolide lead to programmed cell death of MDA-MB-231 breast cancer cell line by Banerjee M1,2, Chattopadhyay S2, Choudhuri T3, Bera R2, Kumar S2, Chakraborty B2, Mukherjee SK4.(PubMed)
(2) 14-Deoxy-11,12-didehydroandrographolide induces DDIT3-dependent endoplasmic reticulum stress-mediated autophagy in T-47D breast carcinoma cells by Tan HK1, Muhammad TS2, Tan ML3.(PubMed)
(3) Inhibition of MDA-MB-231 breast cancer cell migration and invasion activity by andrographolide via suppression of nuclear factor-κB-dependent matrix metalloproteinase-9 expression by Zhai Z1, Qu X1, Li H1, Ouyang Z1, Yan W2, Liu G3, Liu X1, Fan Q1, Tang T1, Dai K1, Qin A1.(PubMed)

#AqueousExtract of Leaves From #Beetroot Exerts Anti Inflammatory Activity by Regulating the Inflammatory Mediator

Kyle J. Norton

Beet may be one functional food, having an anti-inflammatory potential in reducing pain in damaged tissues or local infection.
Inflammation is a natural reaction of the immune system to protect of our body during tissues damage, injure, and infection

Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

According to the Meerut Institute of Engineering & Technology, in the carrageenan-induced paw edema method for acute inflammation and cotton pellet granuloma for chronic inflammation in a rat model, injected aqueous extract of leaves of Beta vulgaris exhibited anti-inflammatory effects at a dose level of 1000 mg/kg in comparison to those of indomethacin, a group of nonsteroidal anti-inflammatory drugs (10 mg/kg).

Also carrageenan (100 µg/paw)-induced paw edema and neutrophil migration to the paw skin tissues. treatment with betalain (100 mg/kg, i.p.) significantly inhibited the expression of paw edema. caused by carrageenan, a common food additive and complete Freund's adjuvant (10 µl/paw) used in animal experiments to induce infection.

Neutrophils are white blood cells that form an important role in defense against infection and inflammation caused by injury and microorganisms invasion and neutrophil migration is a rapid movement of white blood cells to the location of infection or inflammation.


According to the study, the anti-inflammatory effect of the aqueous extract of leaves of Beta vulgaris probably was attributed to phytochemicals found in the extract such as flavonoids, carbohydrates, pentose, amino acids, saponins, tannins, and steroids in promoted and increased movement of plasma and leukocytes from the blood into the injured tissues to counteract the invasion of foreign substances and disease. and exhibited the release of histamine in the generation of mass and white blood cells and serotonin-induced platelets binding to a clot, then ameliorating inflammation through regulation of inflammatory mediators including leukotrienes and prostaglandins,

Please note that
1. Hormone prostaglandins play a key role in the generation of the inflammatory response and stimulation of constriction and clotting of platelets.

2. Leukotrienes (LTs) is a family of lipid and inflammatory mediators with a function in response to pathogenesis of inflammation

The study emphasized that in compared to a group of nonsteroidal anti-inflammatory drugs, an aqueous extract of leaves of Beta vulgaris at a specific dose exhibited a stronger and higher inhibition of acute inflammation induced by prostaglandin synthesis, including the inflammatory response to diverse stimuli in an induced temporary increase of physiological activity.

Further analysis also suggested that in chronic inflammatory diseases induced by cotton pellet granuloma, such as arthritis, aqueous extract of leaves of Beta vulgaris although less effective than the conventional drug of indomethacin, had a profound effect in reduced symptoms and prevented inflammatory process of cells at the site of inflammation by healing of the tissue through the initiated cells shift to induced apoptosis.

In other words, an aqueous extract of leaves of Beta vulgaris ameliorated risk of chronic inflammation by healing the affected tissue, thus preventing cell being damage caused by prolonged inflammation.


Furthermore, the application of betalain (100 mg/kg), isolated from beetroot also suppressed free radical production and inflammatory activity through enhanced antioxidant activity and inhibited the overexpression of pro-inflammatory proteins such as

TNF-α, a tumor necrosis factor, a protein with function in regulating the production of inflammatory cytokines in the acute phase of invasion by foreign substances, and interleukin (IL)-1β have a duo function in the activated either pro-inflammatory cytokine or anti-inflammatory myokines, and promoted
IL-10 expression in the production of an anti-inflammatory cytokine

In healthy adults, with inflammatory bowel diseases (IBD), betanin, the major component of beet (Beta vulgaris var. rubra) also demonstrated a significant anti-inflammatory property in modulated reactive oxygen species (ROS) production and oxidative stress cause of DNA damage as well as increasing apoptosis in neutrophils by analyzing the blood samples of tested subjects.


Dr. Zielińska-Przyjemska M the lead author said, "Betanin treatment at the concentration of 100 μM for 24 h increased DNA damage assessed by comet assay in IBD patients' neutrophils. A similar effect although less pronounced was observed in Caco-2 cells(colon cancer cell line)".

The findings suggested that beet with plenty of phytochemicals may have a therapeutic potential to be utilized in the treatment of inflammation-associated diseases.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-inflammatory activity of aqueous extract of Beta vulgaris L by Jain S1, Garg VK1, Sharma PK1.(PubMed)
(2) Anti-inflammatory activity of betalain-rich dye of Beta vulgaris: effect on edema, leukocyte recruitment, superoxide anion, and cytokine production by Martinez RM1, Longhi-Balbinot DT, Zarpelon AC, Staurengo-Ferrari L, Baracat MM, Georgetti SR, Sassonia RC, Verri WA Jr, Casagrande R.(PubMed)
(3) DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W1.(PubMed)

#Asparagus Processes Antidiarrhoeal Activity by Regulating Vascular Smooth Muscle Contraction and Vasoconstriction

Kyle J. Norton

Asparagus is a flowering plant belonging to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, northwest Germany, northern Africa, and western Asia, used from early times as a vegetable and medicine because its delicate flavor and diuretic properties.
Diarrhea is a condition of frequent discharge of feces in liquid form.

According to the K.P. College of Pharmacy, Asparagus racemosus wild root extract used in traditional herbal medicine exerted the antidiarrhoeal potency against several experimental models of diarrhea in model animals, similar to those of conventional medicine such as loperamide.


This efficacy is attributed to the root extracts in the mediation of Prostaglandin E2 (PGE2), a principal hormone in the expression of inflammatory diseases.
Dr. Venkatesan N., the lead researcher said, "The plant extracts showed significant (P < 0.05) inhibitory activity against castor oil-induced diarrhea and PGE2 induced enter polling in rats when tested at 200 mg/kg. Both extracts also showed significant (P < 0.001) reduction in gastrointestinal motility ".

In support of the above study, the test of the animal model on Alpha-2 blocker (see alpha(2)-adrenoceptor) experimentally-induced diarrhea and ulceration, showed a positive effect of methanolic extract of Asparagus pubescens root in reducing significantly intestinal propulsive movement and intestinal fluid accumulation in (500-1500 mg/kg) in a dose-dependent manner.

In fact, the antidiarrhoeal effect of asparagus may be a result of modulating the expression of alpha(2)-adrenoceptor in regulated vascular smooth muscle contraction and vasoconstriction through Prostaglandin E2 (PGE2) modification. But further studies may be necessary to validate this potency.


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Sources
(1) Anti-diarrhoeal potential of Asparagus racemosus wild root extracts in laboratory animals by Venkatesan N1, Thiyagarajan V, Narayanan S, Arul A, Raja S, Vijaya Kumar SG, Rajarajan T, Perianayagam JB. (PubMed)
(2) Antidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescent root in rats by Nwafor PA1, Okwuasaba FK, Binda LG. (PubMed)

Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.