Kyle J. Norton
Scientists may have a pungent spice that processes the potential to increase levels of testosterone deficiency, particularly in the elderly with no side effects according to studies.
Testosterone is a steroid hormone found in humans made mostly from the testicles in men and a small amount in women's ovaries.
According to epidemiological studies, treatment for hypogonadism is on the rise, particularly in the population due to naturally reduced production of levels of testosterone other than normal aging.
Testosterone production starts to produce significantly during puberty and dip after age 30.
In males, the early onset of reduced production of levels of testosterone is associated with a highly prevalent burden of comorbid medical conditions and polypharmacy complicates compared to those of normal aging,
Also, low levels of testosterone in males are associated with the early onset of metabolic syndrome in the induction of cardiovascular disease and type 2 diabetes.
Conventional medicine used for the treatment in this population is found to be a unique challenge to clinicians.
Apart from normal aging, low levels of testosterone are found to induce symptoms of decreased sex drive, low energy, weight gain, the risk of depression, moodiness, loss of hair, and thinner bones.
If you are experiencing some of the above symptoms, you may have low levels of testosterone. Please make sure you check with your doctor to rule out the possibility.
Dr. Giagulli VA, in examining the complications of testosterone in men wrote, "Testosterone deficiency syndrome (TDS) induces several negative effects that generally involve different organs such as testis, bone, skeletal muscle, and heart, leading to a reduction in testis function, causing osteoporosis, strongly reducing muscle mass, decreasing exercise capacity and strength and facilitating heart failure".
And, " Approximately 25% of patients affected by chronic heart failure (CHF) is characterized by plasma Testosterone (T) levels below normal ranges also related to disease progression".
These results clearly suggested apart from normal aging, males with testosterone deficiency are associated with complications of many ailments.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Scientists on finding a natural compound that processes a function in enhancing and protecting primary sex hormone in males examined the effects of ginger activity in enhancing testosterone production in males.
By searching the PubMed, Scopus, and Web of Science databases for English language articles (full texts or abstracts) from November 1991 through August 2018 using the keywords "ginger" and "Zingiber officinale" versus "testosterone" linking the effects of ginger on testosterone researchers found that ginger supplementation, particularly in oxidative stress conditions, enhances testosterone production in males.
The mechanisms by which this occurs mainly by enhancing luteinizing hormone (LH) production in stimulating the Leydig cell production of testosterone, increasing the level of cholesterol in synthesizing male sex steroid, testosterone (T), by reducing oxidative stress and lipid peroxidation in the testes.
Furthermore, the application of ginger also inhibited the expression of free radicals by promoting the activity of the antioxidant enzymes.
Ginger also normalized the blood glucose by increasing blood flow to the testes.
Moreover, ginger improved the production of testosterone by increasing testicular weight and recycling testosterone receptors.
The finding strongly supports the use of ginger in enhanced testosterone production for the treatment of diseases associated with testosterone deficiency.
In order to reveal more information about ginger in the production of testosterone by examing the
ginger effects on multiple animal models, including 60adult male Sprague Dawley rats divided into * Group A served as normal control,
* Group B received 0.3% lead acetate in drinking water,
*Group C and Group D received supplementary 0.5 and 1 gm/Kg body weight of ginger respectively along with lead acetate in drinking water.
During the experiments, co-administration with different doses of ginger showed a significant rise in the testosterone levels in the teste, compared to the lead-treated group.
Interestingly, ginger application at different doses showed no significant change in LH levels, compared to the rise in the previous ginger treatment,
These results strongly suggested there must be other compounds from ginger that exhibit the increased levels of LH that are not mentioned in both studies.
Taken together, ginger may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of diseases associated with testosterone deficiency.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Ginger and Testosterone by Banihani SA. (PubMed)
(2) Protective role of ginger on lead-induced derangement in plasma testosterone and luteinizing hormone levels of male Sprague Dawley rats by Riaz F1, Khan UA, Ayub M, Shaukat S.(PubMed)
(3) Testosterone deficiency in male: a risk factor for heart failure by Giagulli VA1, Guastamacchia E, De Pergola G, Iacoviello M, Triggiani V.(PubMed)
Monday, 14 August 2023
#Nishamalaki (NA), a Combination of Curcuma longa and Emblica Officinalis Protects the Nerves Against the Onset of Diabetic Neuropathy in Diabetics
Kyle J. Norton
Diabetic neuropathy is a complication of patients with diabetes associated with nerve damage, ranging from pain and numbness in your legs and feet to problems with your digestive system.
Most cases of diabetic neuropathy are involved in diabetics who have a history of hyperglycemia caused by long-term high levels of glucose in the bloodstream, urinary tract, blood vessels, and heart.
Diabetic neuropathy can be classified into 4 main types,.
* Peripheral neuropathy is the most common type of diabetic neuropathy, affecting the nerves that control the feet and legs first, followed by the hands and arms.
* The autonomic neuropathy that affects the nerves that control the heart, bladder, stomach, intestines, sex organs, and eyes.
* Radiculoplexus neuropathy found mostly in older patients affects nerves that control the thighs, hips, buttocks, or legs.
* Mononeuropathy or focal neuropathy also found commonly in older patients affects the nerves that control the face, middle of the body (torso), or leg.
The exact causes of diabetic neuropathy are totally depending on the type of neuropathy. However, damage to nerves and blood vessels in the affected area has been found to induce over time, uncontrolled high blood sugar.
In other words, diabetic neuropathy is preventable by keeping the blood glucose in the healthy range.
Dr. Michael Greger M.D. FACLM in the article "the best diet for diabetic neuropathy" wrote, "
(By examing) people eating different diets found that nine months or more on a strict plant-based diet appeared to remove the trans fat from their bodies (or at least their butts). Their pain, however, didn’t take nine months to get better—it got better in days"
In the explanation of the results, the researcher continued, "More likely, it was due to an improvement in blood flow. “[N]erve biopsies in diabetics with severe progressive neuropathy…have shown small vessel disease within the nerve.” There are blood vessels within our nerves that can get clogged up too. The oxygen levels in the nerves of diabetics were found to be lower than even the levels of oxygenated blood".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the treatment of diabetic neuropathy researchers examined turmeric's antioxidant properties, anti-inflammatory, CNS depressant effect, and antibacterial and antifungal properties.
According to the results of the experiment, turmeric inhibited the pathogenesis of diabetic neuropathy by improving the antioxidant in the reduction of the level of oxidative stress associated with the occurrence of the present complication.
Furthermore, turmeric also enhanced the anti-inflammatory and antibacterial activity against the spread of infection.
In other words, turmeric inhibited diabetic neuropathy through a number of mechanisms involved in antioxidant, anti-inflammatory, and antibacterial activity.
In order to review more information about the turmeric effect, researchers investigated Nishamalaki (NA), a combination of Curcuma longa and Emblica officinalis in the prevention of diabetic neuropathy.
The study included diabetic neuropathy in type 2 diabetic Wistar rats under treatment for 12 weeks.
Selected rats were randomly divided into group I (Control) vehicle-treated consisting of 6 rats and
group II-VII Diabetic Control, NA low dose, NA High dose, Glibenclamide, Pioglitazone, and Epalrestat respectively.
Diabetes-induced in 36 Wistar rats with Streptozotocin (STZ) (35mg/kg) intraperitoneally followed by a High Fat High Fructose diet. After confirmation of the development of diabetes; rats were divided into six groups as the aforementioned division.
Compared to other treatment groups, Nishamalaki (NA) not only controlled hyperglycemia and reduced lipid levels but also effectively prevented the development of diabetic neuropathy.
Taken together, turmeric used alone or combined with other herbal medicine may be considered supplements for the prevention of diabetic neuropathy, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Investigation of the utility of Curcuma caesia in the treatment of diabetic neuropathy by Grover M1, Shah K2, Khullar G3, Gupta J1, Behl T. (PubMed)
(2) Evaluation of Effect of Nishamalaki on STZ and HFHF Diet-Induced Diabetic Neuropathy in Wistar Rats by Dawane JS1, Pandit VA2, Bhosale MS3, Khatavkar PS. (PubMed)(3) Best Diet for Diabetic Neuropathy. Written By Michael Greger M.D. FACLM on January 1st, 2019
Diabetic neuropathy is a complication of patients with diabetes associated with nerve damage, ranging from pain and numbness in your legs and feet to problems with your digestive system.
Most cases of diabetic neuropathy are involved in diabetics who have a history of hyperglycemia caused by long-term high levels of glucose in the bloodstream, urinary tract, blood vessels, and heart.
Diabetic neuropathy can be classified into 4 main types,.
* Peripheral neuropathy is the most common type of diabetic neuropathy, affecting the nerves that control the feet and legs first, followed by the hands and arms.
* The autonomic neuropathy that affects the nerves that control the heart, bladder, stomach, intestines, sex organs, and eyes.
* Radiculoplexus neuropathy found mostly in older patients affects nerves that control the thighs, hips, buttocks, or legs.
* Mononeuropathy or focal neuropathy also found commonly in older patients affects the nerves that control the face, middle of the body (torso), or leg.
The exact causes of diabetic neuropathy are totally depending on the type of neuropathy. However, damage to nerves and blood vessels in the affected area has been found to induce over time, uncontrolled high blood sugar.
In other words, diabetic neuropathy is preventable by keeping the blood glucose in the healthy range.
Dr. Michael Greger M.D. FACLM in the article "the best diet for diabetic neuropathy" wrote, "
(By examing) people eating different diets found that nine months or more on a strict plant-based diet appeared to remove the trans fat from their bodies (or at least their butts). Their pain, however, didn’t take nine months to get better—it got better in days"
In the explanation of the results, the researcher continued, "More likely, it was due to an improvement in blood flow. “[N]erve biopsies in diabetics with severe progressive neuropathy…have shown small vessel disease within the nerve.” There are blood vessels within our nerves that can get clogged up too. The oxygen levels in the nerves of diabetics were found to be lower than even the levels of oxygenated blood".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the treatment of diabetic neuropathy researchers examined turmeric's antioxidant properties, anti-inflammatory, CNS depressant effect, and antibacterial and antifungal properties.
According to the results of the experiment, turmeric inhibited the pathogenesis of diabetic neuropathy by improving the antioxidant in the reduction of the level of oxidative stress associated with the occurrence of the present complication.
Furthermore, turmeric also enhanced the anti-inflammatory and antibacterial activity against the spread of infection.
In other words, turmeric inhibited diabetic neuropathy through a number of mechanisms involved in antioxidant, anti-inflammatory, and antibacterial activity.
In order to review more information about the turmeric effect, researchers investigated Nishamalaki (NA), a combination of Curcuma longa and Emblica officinalis in the prevention of diabetic neuropathy.
The study included diabetic neuropathy in type 2 diabetic Wistar rats under treatment for 12 weeks.
Selected rats were randomly divided into group I (Control) vehicle-treated consisting of 6 rats and
group II-VII Diabetic Control, NA low dose, NA High dose, Glibenclamide, Pioglitazone, and Epalrestat respectively.
Diabetes-induced in 36 Wistar rats with Streptozotocin (STZ) (35mg/kg) intraperitoneally followed by a High Fat High Fructose diet. After confirmation of the development of diabetes; rats were divided into six groups as the aforementioned division.
Compared to other treatment groups, Nishamalaki (NA) not only controlled hyperglycemia and reduced lipid levels but also effectively prevented the development of diabetic neuropathy.
Taken together, turmeric used alone or combined with other herbal medicine may be considered supplements for the prevention of diabetic neuropathy, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Investigation of the utility of Curcuma caesia in the treatment of diabetic neuropathy by Grover M1, Shah K2, Khullar G3, Gupta J1, Behl T. (PubMed)
(2) Evaluation of Effect of Nishamalaki on STZ and HFHF Diet-Induced Diabetic Neuropathy in Wistar Rats by Dawane JS1, Pandit VA2, Bhosale MS3, Khatavkar PS. (PubMed)(3) Best Diet for Diabetic Neuropathy. Written By Michael Greger M.D. FACLM on January 1st, 2019
High Amount of #BeetJuice Intake Daily and Regualrly May be Associated with the Risk of #GastricCancer, Reserachers Suggest
Kyle J. Norton
Beet may be a potential functional food for reduced risk and treatment of pharynx cancer, a recent study suggested
Pharynx cancer is a medical condition of abnormal cell growth in the pharynx region, including the nasopharynx, hypopharynx, and pharyngeal areas. In the late stage, the cancerous cells may travel a distance away to infect other healthy tissues.
Beet, best known as the beetroot or garden beet is a perennial plant with leafy stems growing to 1–2 m tall, belonging to the amaranth family.
According to the joint study led by Vels University, the Phyto-synthetic method of producing silver nanoparticles (Ag-NPs) may be used as a mediator of beetroot in the enhanced treatment of patients with pharynx cancer.
In the pharynx cancer cell line, the silver nanoparticles enhanced by the beetroot effect through induction of cytotoxicity to cause cell death, without harming the nearby healthy cells.
Silver nanoparticles are used to enhance the function of biological treatment alone or combined with other pharmaceutical substances.
Measured by MTT assay, the inhibition efficacy may depend on the higher concentration proportionally of the photosynthetic substance.
AO/EtBr staining observations also found that Ag-NPs exhibited a mechanism of cell death probably through the depolarization of mitochondrial membrane potential caused by depletion of energy in induced cell proliferation, subsequently, in cell apoptosis.
In fact, according to the World Cancer Research Foundation report, strong evidence suggested that vegetables with high nitrate-containing such as beet may have a potential therapeutic effect in reduced risk and treatment of various cancers, including cancer of the pharynx.
Unfortunately, beet juice with a high amount of nitrate may associate with gastric cancer risk according to the review of literature of a total of 22 articles consisting of 49 studies—19 studies for nitrates, 19 studies for nitrites, and 11 studies for N-nitroso dimethylamine (NDMA).
Further analysis, discovered that high nitrates intake was associated with a weak but statistically significant reduced risk of gastric cancer, and increased consumption of nitrites and N-nitrosodimethylamine, NDMA may elevate the risk factors for gastric cancer.
But after taking account of other confounders, the risk of gastric cancer is not attributed to the intake of nitrate but to nitrate beverages with N-nitrosodimethylamine (NDMA) contamination.
Taken together, beet and beet juice with a high concentration of nitrate may be used as a functional food to ameliorate the risk and treatment of pharynx cancer, but people with stomach ailment should avoid drinking any nitrate beverage with N-nitroso dimethylamine (NDMA) contamination.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) The impact of anticancer activity upon Beta vulgaris extract-mediated biosynthesized silver nanoparticles (ag-NPs) against human breast (MCF-7), lung (A549) and pharynx (Hep-2) cancer cell lines by Venugopal K1, Ahmad H2, Manikandan E3, Thanigai Arul K4, Kavitha K5, Moodley MK6, Rajagopal K7, Balabhaskar R8, Bhaskar M9.(PubMed)
(2) Dietary Nitrates, Nitrites, and Nitrosamines Intake and the Risk of Gastric Cancer: A Meta-Analysis by Peng Song,1,† Lei Wu,2,† and Wenxian Guan1(PMC)
(3) It is rocket science - why dietary nitrate is hard to 'beet'! Part II: further mechanisms and therapeutic potential of the nitrate-nitrite-NO pathway by Mills CE1, Khatri J2, Maskell P2, Odongerel C2, Webb AJ2.(PubMed)
Beet may be a potential functional food for reduced risk and treatment of pharynx cancer, a recent study suggested
Pharynx cancer is a medical condition of abnormal cell growth in the pharynx region, including the nasopharynx, hypopharynx, and pharyngeal areas. In the late stage, the cancerous cells may travel a distance away to infect other healthy tissues.
Beet, best known as the beetroot or garden beet is a perennial plant with leafy stems growing to 1–2 m tall, belonging to the amaranth family.
According to the joint study led by Vels University, the Phyto-synthetic method of producing silver nanoparticles (Ag-NPs) may be used as a mediator of beetroot in the enhanced treatment of patients with pharynx cancer.
In the pharynx cancer cell line, the silver nanoparticles enhanced by the beetroot effect through induction of cytotoxicity to cause cell death, without harming the nearby healthy cells.
Silver nanoparticles are used to enhance the function of biological treatment alone or combined with other pharmaceutical substances.
Measured by MTT assay, the inhibition efficacy may depend on the higher concentration proportionally of the photosynthetic substance.
AO/EtBr staining observations also found that Ag-NPs exhibited a mechanism of cell death probably through the depolarization of mitochondrial membrane potential caused by depletion of energy in induced cell proliferation, subsequently, in cell apoptosis.
In fact, according to the World Cancer Research Foundation report, strong evidence suggested that vegetables with high nitrate-containing such as beet may have a potential therapeutic effect in reduced risk and treatment of various cancers, including cancer of the pharynx.
Unfortunately, beet juice with a high amount of nitrate may associate with gastric cancer risk according to the review of literature of a total of 22 articles consisting of 49 studies—19 studies for nitrates, 19 studies for nitrites, and 11 studies for N-nitroso dimethylamine (NDMA).
Further analysis, discovered that high nitrates intake was associated with a weak but statistically significant reduced risk of gastric cancer, and increased consumption of nitrites and N-nitrosodimethylamine, NDMA may elevate the risk factors for gastric cancer.
But after taking account of other confounders, the risk of gastric cancer is not attributed to the intake of nitrate but to nitrate beverages with N-nitrosodimethylamine (NDMA) contamination.
Taken together, beet and beet juice with a high concentration of nitrate may be used as a functional food to ameliorate the risk and treatment of pharynx cancer, but people with stomach ailment should avoid drinking any nitrate beverage with N-nitroso dimethylamine (NDMA) contamination.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) The impact of anticancer activity upon Beta vulgaris extract-mediated biosynthesized silver nanoparticles (ag-NPs) against human breast (MCF-7), lung (A549) and pharynx (Hep-2) cancer cell lines by Venugopal K1, Ahmad H2, Manikandan E3, Thanigai Arul K4, Kavitha K5, Moodley MK6, Rajagopal K7, Balabhaskar R8, Bhaskar M9.(PubMed)
(2) Dietary Nitrates, Nitrites, and Nitrosamines Intake and the Risk of Gastric Cancer: A Meta-Analysis by Peng Song,1,† Lei Wu,2,† and Wenxian Guan1(PMC)
(3) It is rocket science - why dietary nitrate is hard to 'beet'! Part II: further mechanisms and therapeutic potential of the nitrate-nitrite-NO pathway by Mills CE1, Khatri J2, Maskell P2, Odongerel C2, Webb AJ2.(PubMed)
#Herbal #Bilberry Inhibits the Serum Lipids and Lipoproteins Associated with #CardiometabolicRisk Factors, According to Studies
Kyle J. Norton
In seeking natural therapy with no side effects, scientists may have a whole fruit for the inhibition of cardiometabolic risk factors (CRFs) associated with the onset of cardiovascular disease,, according to studies.
Cardiovascular disease is a class of diseases involving the blood vessels and heart, depending on the location or area that has been affected.
Cardiometabolic risk factors (CRFs) are conditions that cause damage to the heart and blood vessels. Some researchers suggested that cardiometabolic risk factors are a cluster of conditions that causes the onset of diabetes, heart disease, or stroke.
Cardiometabolic risk factors can be classified into preventable and nonpreventable risks
* Preventable risk factors can be lowered by making a change of lifestyle such as following a healthy diet, quitting smoking, losing weight, and exercising daily and moderately.
According to epidemiological studies, a healthy lifestyle has been found to reduce risks of metabolic syndrome, a cluster of conditions associated with the cardiometabolic risk, including lower high blood sugar, cholesterol, and pressure.
* Nonpreventable risks are the risk that cannot be changed including aging, ethnicity, family history, medical condition,...
Out of a number of risk factors, some researchers suggested that prevalent obesity may be the major culprit that causes the onset of diabetes and cardiovascular disease in the Western world.
According to the data provided by the Centers for Disease Control and Prevention, "Among participants with overweight (52.5% of the sample), 18.6% had none of the 4 CRFs. Among the 47.5% of participants with obesity, 9.6% had none; among participants with morbid obesity, 5.8% had none. Age was strongly associated with CRFs in multivariable analysis".
The results are according to the measurement of elevated blood pressure (systolic ≥130 mm Hg or diastolic >85 mm Hg or ICD-9-CM [International Classification of Diseases, Ninth Revision, Clinical Modification] diagnosis code 401.0–405.9); elevated triglycerides (≥150 mg/dL or ICD-9-CM 272.1); low high-density lipoprotein cholesterol (<40 mg/dL for men or <50 mg/dL for women or ICD-9-CM 272.5); and prediabetes (fasting glucose 100–125 mg/dL or HbA1c 5.7%–6.4% or ICD-9-CM 790.2x).
The results strongly suggested if you are overweight or obese, you are at an increased risk of diabetes and cardiovascular disease compared to those who do not.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
With an aim to find a natural whole food for the inhibition of cardiometabolic risk factors that increase the risk of CVD and diabetes, researchers examined the effect of baseline metabolome on the overall metabolic responses to berry intake.
The study included 80 overweight women who completed the randomized crossover study randomly assigned to consume dried sea buckthorn berries (SBs), sea buckthorn oil (SBo), sea buckthorn phenolics ethanol extract mixed with maltodextrin (SBe+MD) (1:1), or frozen bilberries for 30 days.
By comparing the metabolic profile that reflected higher cardiometabolic risk(group B) at baseline, and participants who had a lower-risk profile (group A), researchers showed that bilberries caused beneficial changes in serum lipids and lipoproteins in group B, whereas the opposite was true in group A.
In other words, bilberry exerted a protective effect against people with cardiometabolic risk without causing harm to people with lower risk profiles.
In order to reveal more information about bilberry inhibition of cardiovascular risk factors researchers investigated regular consumption of bilberries effects on CVD risk reduction, such as decreasing low-density lipoprotein cholesterol (LDL-C) and triglycerides (TGs) and increasing high-density lipoprotein cholesterol (HDL-C).
The study involved women (n=25) and men (n=11) who consumed 150 g of frozen stored bilberries 3 times a week for 6 weeks.
During the experiment, the consumption of bilberries led to a decrease in total cholesterol, LDL-C, TG, glucose, albumin, γ-glutamyltransferase, and a positive increase in HDL-C (P=.044). In both women and men.
However, in men, additionally, favorable changes were observed in total cholesterol, glucose, albumin, aspartate aminotransferase, γ-glutamyltransferase, and HDL-C.
Dr. the lead scientist said, "the regular intake of bilberries can be important to reduce CVD risk, by decreasing LDL-C/TG and increasing HDL-C".
Taken altogether, bilberry may be considered a functioning remedy for the inhibition of cardiometabolic risk factors and prevention of CVD, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial by Larmo PS1, Kangas AJ, Soininen P, Lehtonen HM, Suomela JP, Yang B, Viikari J, Ala-Korpela M, Kallio HP. (PubMed)
(2) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(3) Cardiometabolic Risk Factors Among 1.3 Million Adults With Overweight or Obesity, but Not Diabetes, in 10 Geographically Diverse Regions of the United States, 2012–2013. ORIGINAL RESEARCH — Volume 14 — March 9, 2017. (CDC)
In seeking natural therapy with no side effects, scientists may have a whole fruit for the inhibition of cardiometabolic risk factors (CRFs) associated with the onset of cardiovascular disease,, according to studies.
Cardiovascular disease is a class of diseases involving the blood vessels and heart, depending on the location or area that has been affected.
Cardiometabolic risk factors (CRFs) are conditions that cause damage to the heart and blood vessels. Some researchers suggested that cardiometabolic risk factors are a cluster of conditions that causes the onset of diabetes, heart disease, or stroke.
Cardiometabolic risk factors can be classified into preventable and nonpreventable risks
* Preventable risk factors can be lowered by making a change of lifestyle such as following a healthy diet, quitting smoking, losing weight, and exercising daily and moderately.
According to epidemiological studies, a healthy lifestyle has been found to reduce risks of metabolic syndrome, a cluster of conditions associated with the cardiometabolic risk, including lower high blood sugar, cholesterol, and pressure.
* Nonpreventable risks are the risk that cannot be changed including aging, ethnicity, family history, medical condition,...
Out of a number of risk factors, some researchers suggested that prevalent obesity may be the major culprit that causes the onset of diabetes and cardiovascular disease in the Western world.
According to the data provided by the Centers for Disease Control and Prevention, "Among participants with overweight (52.5% of the sample), 18.6% had none of the 4 CRFs. Among the 47.5% of participants with obesity, 9.6% had none; among participants with morbid obesity, 5.8% had none. Age was strongly associated with CRFs in multivariable analysis".
The results are according to the measurement of elevated blood pressure (systolic ≥130 mm Hg or diastolic >85 mm Hg or ICD-9-CM [International Classification of Diseases, Ninth Revision, Clinical Modification] diagnosis code 401.0–405.9); elevated triglycerides (≥150 mg/dL or ICD-9-CM 272.1); low high-density lipoprotein cholesterol (<40 mg/dL for men or <50 mg/dL for women or ICD-9-CM 272.5); and prediabetes (fasting glucose 100–125 mg/dL or HbA1c 5.7%–6.4% or ICD-9-CM 790.2x).
The results strongly suggested if you are overweight or obese, you are at an increased risk of diabetes and cardiovascular disease compared to those who do not.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
With an aim to find a natural whole food for the inhibition of cardiometabolic risk factors that increase the risk of CVD and diabetes, researchers examined the effect of baseline metabolome on the overall metabolic responses to berry intake.
The study included 80 overweight women who completed the randomized crossover study randomly assigned to consume dried sea buckthorn berries (SBs), sea buckthorn oil (SBo), sea buckthorn phenolics ethanol extract mixed with maltodextrin (SBe+MD) (1:1), or frozen bilberries for 30 days.
By comparing the metabolic profile that reflected higher cardiometabolic risk(group B) at baseline, and participants who had a lower-risk profile (group A), researchers showed that bilberries caused beneficial changes in serum lipids and lipoproteins in group B, whereas the opposite was true in group A.
In other words, bilberry exerted a protective effect against people with cardiometabolic risk without causing harm to people with lower risk profiles.
In order to reveal more information about bilberry inhibition of cardiovascular risk factors researchers investigated regular consumption of bilberries effects on CVD risk reduction, such as decreasing low-density lipoprotein cholesterol (LDL-C) and triglycerides (TGs) and increasing high-density lipoprotein cholesterol (HDL-C).
The study involved women (n=25) and men (n=11) who consumed 150 g of frozen stored bilberries 3 times a week for 6 weeks.
During the experiment, the consumption of bilberries led to a decrease in total cholesterol, LDL-C, TG, glucose, albumin, γ-glutamyltransferase, and a positive increase in HDL-C (P=.044). In both women and men.
However, in men, additionally, favorable changes were observed in total cholesterol, glucose, albumin, aspartate aminotransferase, γ-glutamyltransferase, and HDL-C.
Dr. the lead scientist said, "the regular intake of bilberries can be important to reduce CVD risk, by decreasing LDL-C/TG and increasing HDL-C".
Taken altogether, bilberry may be considered a functioning remedy for the inhibition of cardiometabolic risk factors and prevention of CVD, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial by Larmo PS1, Kangas AJ, Soininen P, Lehtonen HM, Suomela JP, Yang B, Viikari J, Ala-Korpela M, Kallio HP. (PubMed)
(2) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(3) Cardiometabolic Risk Factors Among 1.3 Million Adults With Overweight or Obesity, but Not Diabetes, in 10 Geographically Diverse Regions of the United States, 2012–2013. ORIGINAL RESEARCH — Volume 14 — March 9, 2017. (CDC)
#Asparagus Extract Exhibits Hypoglycaemic and Hypotriglyceridaemic Effects on #Diabetes, Scientists Say
Kyle J. Norton
Asparagus may have a potential and profound effect in reducing the risk of diabetes in patients with no diabetes and diabetic complications in patients with diabetes, some studies suggested.
Diabetes is a condition characterized by insufficient insulin entering the bloodstream to regulate glucose.
The actual causes of diabetes are debatable. As researchers do not know why some people without genetic mutations are susceptible to disease development, while others do not.
Researchers believed that the onset of diabetes type 2 is associated with a set of risk factors. According to the retrospective cohort study, using the data of 8337 adolescent respondents from Add Health (1994-2008) including 5131 non-Hispanic Whites, 1651 non-Hispanic Blacks, 1223 Hispanics, and 332 American Indians/Alaska Natives led by College of Medicine, Washington State University,
* Pre-diabetes and diabetes were more prevalent in non-Hispanic blacks (55% and 12%, respectively) than in American Indians/Alaska Natives (43% and 11%),
* Higher body mass index and family history of diabetes were associated with a higher risk of pre-diabetes and diabetes.
* Female sex was associated with a lower risk of pre-diabetes compared to male counterparts.
Furthermore
* Physical inactivity, sedentary behaviors, or fast food consumption are associated with independent and preventive risk factors that induce the early onset of prediabetes and diabetes.
Most people with prediabetes do not experience any symptoms. However, untreated diabetes or diabetes that do not manage properly, may lead to serious complications of cardiovascular diseases, kidney damage, nerve, foot, and eye damage, skin wounds that can heal,....... and dementia such as Alzheimer's disease.
Asparagus is a flowering plant belonging to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, northwest Germany, northern Africa, and western Asia.
The vegetable has been used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.
In Streptozotocin (90 mg/kg) injected in 2-d-old Wistar rat pups to induce non-obese type 2 diabetes, researchers found that rats treated with a methanolic extract of A. officinalis seeds (250 and 500 mg/kg per d) expressed lowering fasting blood glucose, improved serum insulin, total antioxidant status and qualitative and quantitative in β-cell function(1) compared to a placebo group.
Additional observation also discovered that the methanolic extract also exerts a significant effect in reducing complications of kidney disease by inhibiting renal hypertrophy, polyuria, hyperfiltration, microalbuminuria, and abnormal changes in the renal tissue(1).
Furthermore, asparagus extract enhanced the production of antioxidants from the host in neutralizing the unbalanced ratio of antioxidants and free radicals in initiated oxidative stress(1) induced by the injection of Streptozotocin (90 mg/kg) effectively.
Moreover, according to the study by Smt. Kashibai Navale College of Pharmacy, oral administration of ethanolic extract of Asparagus racemosus (EEAR) at a dose level of 100 and 250 mg/kg daily for 4 weeks, significantly reduced the expression of streptozotocin-induced early diabetic nephropathy in compared with a control group(2).
Dr. Somania R, the lead researcher said, " A. racemosus treatment significantly decreased plasma glucose, creatinine, ..... total cholesterol and triglyceride levels. Renal hypertrophy,....and abnormal changes in the renal tissue".
This efficacy can be attributed to the extract's anti-diabetic effects by improving insulin secretion and β-cell function(2).
Interestingly, the 21 days continuous administration of aqueous extract of asparagus by-product (AEA) to examine the hypoglycaemic effect in a streptozotocin (STZ)-induced diabetic rat model indicated(3), found
* Rat treated with the extract showed decreased fasting serum glucose and triglyceride levels but markedly increased body weight and hepatic glycogen level.
* In an oral glucose tolerance test, both the blood glucose level measured at 30, 60, and 120 min after glucose loading and the area under the glucose curve showed a significant decrease after AEA treatment.
* The extract also exhibited hypoglycaemic and hypotriglyceridaemic effects in preventing diabetic complications associated with hyperglycemia and hyperlipidemia (3).
Taking it all together, there is no doubt that many aspects have contributed to the effectiveness of asparagus in reducing the risk of diabetic complications and treatment of diabetes, but a large amount of asparagus extract intake should only be prescribed by related field specialists.
However, further data collection on large example size and multi centers clinical studies and trials performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of asparagus anti-diabetes possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Asparagus racemosus Willd (Liliaceae) ameliorates early diabetic nephropathy in STZ-induced diabetic rats by Somania R1, Singhai AK, Shivgunde P, Jain D.(PubMed)
(2) Asparagus officinalis extract controls blood glucose by improving insulin secretion and β-cell function in streptozotocin-induced type 2 diabetic rats by Hafizur RM1, Kabir N, Chishti S.(PubMed)
(3) The aqueous extract of Asparagus officinalis L. by-product exerts hypoglycaemic activity in streptozotocin-induced diabetic rats by Zhao J1, Zhang W, Zhu X, Zhao D, Wang K, Wang R, Qu W.(PubMed)
(4) Risk factors for pre-diabetes and diabetes in adolescence and their variability by race and ethnicity by Zamora-Kapoor A1, Fyfe-Johnson A2, Omidpanah A2, Buchwald D2, Sinclair K(PubMed)
Asparagus may have a potential and profound effect in reducing the risk of diabetes in patients with no diabetes and diabetic complications in patients with diabetes, some studies suggested.
Diabetes is a condition characterized by insufficient insulin entering the bloodstream to regulate glucose.
The actual causes of diabetes are debatable. As researchers do not know why some people without genetic mutations are susceptible to disease development, while others do not.
Researchers believed that the onset of diabetes type 2 is associated with a set of risk factors. According to the retrospective cohort study, using the data of 8337 adolescent respondents from Add Health (1994-2008) including 5131 non-Hispanic Whites, 1651 non-Hispanic Blacks, 1223 Hispanics, and 332 American Indians/Alaska Natives led by College of Medicine, Washington State University,
* Pre-diabetes and diabetes were more prevalent in non-Hispanic blacks (55% and 12%, respectively) than in American Indians/Alaska Natives (43% and 11%),
* Higher body mass index and family history of diabetes were associated with a higher risk of pre-diabetes and diabetes.
* Female sex was associated with a lower risk of pre-diabetes compared to male counterparts.
Furthermore
* Physical inactivity, sedentary behaviors, or fast food consumption are associated with independent and preventive risk factors that induce the early onset of prediabetes and diabetes.
Most people with prediabetes do not experience any symptoms. However, untreated diabetes or diabetes that do not manage properly, may lead to serious complications of cardiovascular diseases, kidney damage, nerve, foot, and eye damage, skin wounds that can heal,....... and dementia such as Alzheimer's disease.
Asparagus is a flowering plant belonging to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, northwest Germany, northern Africa, and western Asia.
The vegetable has been used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.
In Streptozotocin (90 mg/kg) injected in 2-d-old Wistar rat pups to induce non-obese type 2 diabetes, researchers found that rats treated with a methanolic extract of A. officinalis seeds (250 and 500 mg/kg per d) expressed lowering fasting blood glucose, improved serum insulin, total antioxidant status and qualitative and quantitative in β-cell function(1) compared to a placebo group.
Additional observation also discovered that the methanolic extract also exerts a significant effect in reducing complications of kidney disease by inhibiting renal hypertrophy, polyuria, hyperfiltration, microalbuminuria, and abnormal changes in the renal tissue(1).
Furthermore, asparagus extract enhanced the production of antioxidants from the host in neutralizing the unbalanced ratio of antioxidants and free radicals in initiated oxidative stress(1) induced by the injection of Streptozotocin (90 mg/kg) effectively.
Moreover, according to the study by Smt. Kashibai Navale College of Pharmacy, oral administration of ethanolic extract of Asparagus racemosus (EEAR) at a dose level of 100 and 250 mg/kg daily for 4 weeks, significantly reduced the expression of streptozotocin-induced early diabetic nephropathy in compared with a control group(2).
Dr. Somania R, the lead researcher said, " A. racemosus treatment significantly decreased plasma glucose, creatinine, ..... total cholesterol and triglyceride levels. Renal hypertrophy,....and abnormal changes in the renal tissue".
This efficacy can be attributed to the extract's anti-diabetic effects by improving insulin secretion and β-cell function(2).
Interestingly, the 21 days continuous administration of aqueous extract of asparagus by-product (AEA) to examine the hypoglycaemic effect in a streptozotocin (STZ)-induced diabetic rat model indicated(3), found
* Rat treated with the extract showed decreased fasting serum glucose and triglyceride levels but markedly increased body weight and hepatic glycogen level.
* In an oral glucose tolerance test, both the blood glucose level measured at 30, 60, and 120 min after glucose loading and the area under the glucose curve showed a significant decrease after AEA treatment.
* The extract also exhibited hypoglycaemic and hypotriglyceridaemic effects in preventing diabetic complications associated with hyperglycemia and hyperlipidemia (3).
Taking it all together, there is no doubt that many aspects have contributed to the effectiveness of asparagus in reducing the risk of diabetic complications and treatment of diabetes, but a large amount of asparagus extract intake should only be prescribed by related field specialists.
However, further data collection on large example size and multi centers clinical studies and trials performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of asparagus anti-diabetes possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Asparagus racemosus Willd (Liliaceae) ameliorates early diabetic nephropathy in STZ-induced diabetic rats by Somania R1, Singhai AK, Shivgunde P, Jain D.(PubMed)
(2) Asparagus officinalis extract controls blood glucose by improving insulin secretion and β-cell function in streptozotocin-induced type 2 diabetic rats by Hafizur RM1, Kabir N, Chishti S.(PubMed)
(3) The aqueous extract of Asparagus officinalis L. by-product exerts hypoglycaemic activity in streptozotocin-induced diabetic rats by Zhao J1, Zhang W, Zhu X, Zhao D, Wang K, Wang R, Qu W.(PubMed)
(4) Risk factors for pre-diabetes and diabetes in adolescence and their variability by race and ethnicity by Zamora-Kapoor A1, Fyfe-Johnson A2, Omidpanah A2, Buchwald D2, Sinclair K(PubMed)
#Tomatoes Improve the Anti-Inflammatory Activity Against the Lung Injury Caused by Breathing Hyperoxic Gas
Kyle J. Norton
Pulmonary diseases are a class of diseases associated with the lungs, including asthma, COPD, influenza, pneumonia and tuberculosis, and lung cancer.
In other words, any diseases involved in breathing problems that reduce the function of the lung are pulmonary diseases.
The most common pulmonary diseases are
* Asthma
Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages and mostly starts during childhood.
* Pneumothorax
Pneumothorax is a condition of collection of air within the pleural cavity, from either the outside or from the lung.
* Bronchitis
Bronchitis is a condition of an inflammation of the mucous membranes of the bronchi, the larger and medium-sized airways that carry airflow from the trachea into the lung parenchyma.
* COPD (chronic obstructive pulmonary disease)** Emphysema is a type of COPD with a long-term and progressive condition that causes shortness of breath, depending on the stage of lung function associated with the damage of tissues of the air sacs (alveoli) in the lungs.
** Chronic bronchitis
Chronic bronchitis is a chronic inflammation of the lung’s bronchi that cause the increased production of mucus in the lung associated with difficulty of breathing.
*Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer are derived from epithelial cells
* PneumoniaPneumonia is a condition of the inflammation of the lung caused by bacteria, such as bacterial infection, Streptococcus pneumonia, or influenza viruses in most cases.
* Pulmonary edema
Pulmonary edema is a condition of fluid accumulation in the air spaces and parenchyma of the lungs that lead to difficulty breathing and respiratory failure.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential ingredient for the treatment of pulmonary disease, researchers examined the dietary supplementation of tomato juice, TJ protection against the developing lung injury caused by breathing hyperoxic gas.
Neonatal mice (C57BL6/J) breathed either 65% O2 (hyperoxia) or room air from birth until postnatal day 7 (P7d)selected for the study underwent necropsy at P7d or raised in room air until adulthood (P56d). In a subset of both groups, drinking water was replaced with TJ (diluted 50:50 in water) from late gestation to necropsy.
In P7d, TJ injection increased pulmonary total antioxidants (TAC) and COL1α1 expression associated with pulmonary fibrosis and attenuated the hyperoxia-induced increase in production ROS without affecting the changes in lung structure.
Furthermore, in P56d, TJ increased TAC, decreased oxidative stress, and reversed the hyperoxia-induced increase in bronchiolar smooth muscle by ameliorating the production of pro-inflammatory cytokines.
Based on the findings, researchers said, "TJ supplementation during and after neonatal exposure to hyperoxia protects the lung from some but not all aspects of hyperoxia-induced injury".
In other words, TJ protects the lung against injury by stimulating the expression of the circulation of antioxidant concentration.
Taken together, tomatoes may be considered supplements for the prevention and treatment of pulmonary diseases, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Impact of Dietary Tomato Juice on Changes in Pulmonary Oxidative Stress, Inflammation, and Structure Induced by Neonatal Hyperoxia in Mice (Mus musculus) by Bouch S1, Harding R1, O'Reilly M1, Wood LG2, Sozo F. (PubMed)
(2) Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression by Yan KH1, Lee LM, Yan SH, Huang HC, Li CC, Lin HT, Chen PS. (PubMed)
Pulmonary diseases are a class of diseases associated with the lungs, including asthma, COPD, influenza, pneumonia and tuberculosis, and lung cancer.
In other words, any diseases involved in breathing problems that reduce the function of the lung are pulmonary diseases.
The most common pulmonary diseases are
* Asthma
Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages and mostly starts during childhood.
* Pneumothorax
Pneumothorax is a condition of collection of air within the pleural cavity, from either the outside or from the lung.
* Bronchitis
Bronchitis is a condition of an inflammation of the mucous membranes of the bronchi, the larger and medium-sized airways that carry airflow from the trachea into the lung parenchyma.
* COPD (chronic obstructive pulmonary disease)** Emphysema is a type of COPD with a long-term and progressive condition that causes shortness of breath, depending on the stage of lung function associated with the damage of tissues of the air sacs (alveoli) in the lungs.
** Chronic bronchitis
Chronic bronchitis is a chronic inflammation of the lung’s bronchi that cause the increased production of mucus in the lung associated with difficulty of breathing.
*Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer are derived from epithelial cells
* PneumoniaPneumonia is a condition of the inflammation of the lung caused by bacteria, such as bacterial infection, Streptococcus pneumonia, or influenza viruses in most cases.
* Pulmonary edema
Pulmonary edema is a condition of fluid accumulation in the air spaces and parenchyma of the lungs that lead to difficulty breathing and respiratory failure.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential ingredient for the treatment of pulmonary disease, researchers examined the dietary supplementation of tomato juice, TJ protection against the developing lung injury caused by breathing hyperoxic gas.
Neonatal mice (C57BL6/J) breathed either 65% O2 (hyperoxia) or room air from birth until postnatal day 7 (P7d)selected for the study underwent necropsy at P7d or raised in room air until adulthood (P56d). In a subset of both groups, drinking water was replaced with TJ (diluted 50:50 in water) from late gestation to necropsy.
In P7d, TJ injection increased pulmonary total antioxidants (TAC) and COL1α1 expression associated with pulmonary fibrosis and attenuated the hyperoxia-induced increase in production ROS without affecting the changes in lung structure.
Furthermore, in P56d, TJ increased TAC, decreased oxidative stress, and reversed the hyperoxia-induced increase in bronchiolar smooth muscle by ameliorating the production of pro-inflammatory cytokines.
Based on the findings, researchers said, "TJ supplementation during and after neonatal exposure to hyperoxia protects the lung from some but not all aspects of hyperoxia-induced injury".
In other words, TJ protects the lung against injury by stimulating the expression of the circulation of antioxidant concentration.
Taken together, tomatoes may be considered supplements for the prevention and treatment of pulmonary diseases, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Impact of Dietary Tomato Juice on Changes in Pulmonary Oxidative Stress, Inflammation, and Structure Induced by Neonatal Hyperoxia in Mice (Mus musculus) by Bouch S1, Harding R1, O'Reilly M1, Wood LG2, Sozo F. (PubMed)
(2) Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression by Yan KH1, Lee LM, Yan SH, Huang HC, Li CC, Lin HT, Chen PS. (PubMed)
#Herbal #TurmericExtracts Inhibit #Psychiatric Overtones and Proteins Assoviated with the Death of Neurons, Reserachers Find
Kyle J. Norton
Scientists may have found a herbal spice that processed bioactive ingredients for the treatment of neuro-disorder with no side effects, according to studies.
Neuroprotection is an action involved in the use of a natural substance to protect the integrity and viability of neurons against damage or death.
Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.
The most common disease associated with neurodegenerative diseases is dementia, a cluster of conditions including Parkinson’s, Alzheimer’s, and Huntington’s disease.
The disease has been found to negatively influence the body's functioning, including balance, movement, talking, breathing, and heart function.
There are many risk factors that cause the onset of the progressive death of brain neurons. Genetic preposition, medical condition, such as alcoholism, brain cancer, or a stroke in the brain.
A prolonged period of toxins and toxic chemicals accumulated that affect brain function also has a strong impact to induce the onset of the disease.
Out of many factors, some researchers suggested that the prevalence of obesity may process some negative implications in stimulating the rise of neurodegenerative disease in older adults in the Western world.
Dr. Daniel Shalev, the lead scientist wrote, "So how does obesity or diabetes contribute to a 50% increase in the risk of dementia?".
And, "Many of the same processes that affect coronary arteries and visceral organs also impact the brain. Inflammation leads to the activation of microglia and astrocytes. This causes the release of cytokines and reactive oxidants, ultimately leading to neuronal dysfunction or death. Critically, this process can unleash a vicious cycle: dying neurons can cause more inflammation, thereby creating a cascade of neurodegeneration".
The findings strongly suggested if you are obese, your risk of dementia is substantially higher compared to non-obese individuals.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound that processes neuroprotective activity, researchers evaluated the neuroprotective effects of extracts from the radix of C. aromatica (ECAs, Turmeric) on free radical damage cells.
The study included the model of oxidative stress damage (H2O2-damaged PC12 cells) induced by injection of 400 µM H2O2.
Compared to ECAs at the same doses, 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) from turmeric showed markedly the increase in the rate of neuron survival and enhancement of the antioxidant enzyme activities via the inhibition of the level of ROS.
In other words, 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) from turmeric exerted better neuron-protective and antioxidant activity than of ECAs.
Furthermore, the 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) also attenuated the intracellular Ca2+ overloading in the induction of psychiatric overtones, such as depression, anxiety, cognitive dysfunction and decreased the activation of proteins and matrixes involved cell apoptosis, similar to those of ECAs.
The efficacy of the 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) against the degeneration of neurons was attributed to the presence of the active compound diarylheptanoids.
Based on the finding, researchers wrote, "These findings indicated that the effects of HCECA and MCECA on inhibiting the cells damage induced by H2O2 in PC12 are better than other extracts from the radix of C. aromatica".
In order to reveal more information about turmeric neuroprotective effects, researchers evaluated the effects of curcumin against nicotine-induced apoptosis, oxidative stress, and inflammation in an animal model.
This study included 60 adult male rats divided randomly into six groups. Group 1 received 0.7 ml/rat normal saline, and group 2 received 6 mg/kg nicotine. Groups 3, 4, 5, and 6 were treated concurrently with nicotine (6 mg/kg) and curcumin (10, 20, 40, and 60 mg/kg i.p. respectively) for 21 days.
According to the Open Field Test (OFT), curcumin-treated groups (40 and 60 mg/kg) reduced nicotine-induced motor activity disturbances.
Before the injection of curcumin nicotine treatment showed the increase of lipid peroxidation observed by the overexpression of ROS, proinflammatory cytokines, and protein associated with neuron apoptosis in the hippocampus.
Furthermore, nicotine also reduced the activity of antioxidant enzymes in the tested rats in the hippocampus.
Injection of curcumin reversed all alternation by attenuating nicotine-induced apoptosis, oxidative stress, and inflammation; and elevating the levels of P-CREB and BDNF associated with the improvement of cognitive function,
Taken altogether, turmeric and its bioactive compounds, particularly curcumin may be considered a supplement for the protection of neuron integrity, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective Effects of Extracts from the Radix Curcuma aromatica on H2O2-induced Damage in PC12 Cells by Liu J1, Zhang L1, Liu D1, Li B1, Zhang M. (PubMed)
(2) The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is Mediated by CREB-BDNF Signaling Pathway by Motaghinejad M1, Motevalian M2, Fatima S2, Faraji F2, Mozaffari S. (PubMed)
(3) Metabolism and Memory: Obesity, Diabetes, and Dementia by Daniel Shalev and Melissa R. Arbuckle. (PMC)
Scientists may have found a herbal spice that processed bioactive ingredients for the treatment of neuro-disorder with no side effects, according to studies.
Neuroprotection is an action involved in the use of a natural substance to protect the integrity and viability of neurons against damage or death.
Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.
The most common disease associated with neurodegenerative diseases is dementia, a cluster of conditions including Parkinson’s, Alzheimer’s, and Huntington’s disease.
The disease has been found to negatively influence the body's functioning, including balance, movement, talking, breathing, and heart function.
There are many risk factors that cause the onset of the progressive death of brain neurons. Genetic preposition, medical condition, such as alcoholism, brain cancer, or a stroke in the brain.
A prolonged period of toxins and toxic chemicals accumulated that affect brain function also has a strong impact to induce the onset of the disease.
Out of many factors, some researchers suggested that the prevalence of obesity may process some negative implications in stimulating the rise of neurodegenerative disease in older adults in the Western world.
Dr. Daniel Shalev, the lead scientist wrote, "So how does obesity or diabetes contribute to a 50% increase in the risk of dementia?".
And, "Many of the same processes that affect coronary arteries and visceral organs also impact the brain. Inflammation leads to the activation of microglia and astrocytes. This causes the release of cytokines and reactive oxidants, ultimately leading to neuronal dysfunction or death. Critically, this process can unleash a vicious cycle: dying neurons can cause more inflammation, thereby creating a cascade of neurodegeneration".
The findings strongly suggested if you are obese, your risk of dementia is substantially higher compared to non-obese individuals.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound that processes neuroprotective activity, researchers evaluated the neuroprotective effects of extracts from the radix of C. aromatica (ECAs, Turmeric) on free radical damage cells.
The study included the model of oxidative stress damage (H2O2-damaged PC12 cells) induced by injection of 400 µM H2O2.
Compared to ECAs at the same doses, 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) from turmeric showed markedly the increase in the rate of neuron survival and enhancement of the antioxidant enzyme activities via the inhibition of the level of ROS.
In other words, 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) from turmeric exerted better neuron-protective and antioxidant activity than of ECAs.
Furthermore, the 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) also attenuated the intracellular Ca2+ overloading in the induction of psychiatric overtones, such as depression, anxiety, cognitive dysfunction and decreased the activation of proteins and matrixes involved cell apoptosis, similar to those of ECAs.
The efficacy of the 95% EtOH extract (HCECA) and 75% EtOH extract (MCECA) against the degeneration of neurons was attributed to the presence of the active compound diarylheptanoids.
Based on the finding, researchers wrote, "These findings indicated that the effects of HCECA and MCECA on inhibiting the cells damage induced by H2O2 in PC12 are better than other extracts from the radix of C. aromatica".
In order to reveal more information about turmeric neuroprotective effects, researchers evaluated the effects of curcumin against nicotine-induced apoptosis, oxidative stress, and inflammation in an animal model.
This study included 60 adult male rats divided randomly into six groups. Group 1 received 0.7 ml/rat normal saline, and group 2 received 6 mg/kg nicotine. Groups 3, 4, 5, and 6 were treated concurrently with nicotine (6 mg/kg) and curcumin (10, 20, 40, and 60 mg/kg i.p. respectively) for 21 days.
According to the Open Field Test (OFT), curcumin-treated groups (40 and 60 mg/kg) reduced nicotine-induced motor activity disturbances.
Before the injection of curcumin nicotine treatment showed the increase of lipid peroxidation observed by the overexpression of ROS, proinflammatory cytokines, and protein associated with neuron apoptosis in the hippocampus.
Furthermore, nicotine also reduced the activity of antioxidant enzymes in the tested rats in the hippocampus.
Injection of curcumin reversed all alternation by attenuating nicotine-induced apoptosis, oxidative stress, and inflammation; and elevating the levels of P-CREB and BDNF associated with the improvement of cognitive function,
Taken altogether, turmeric and its bioactive compounds, particularly curcumin may be considered a supplement for the protection of neuron integrity, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective Effects of Extracts from the Radix Curcuma aromatica on H2O2-induced Damage in PC12 Cells by Liu J1, Zhang L1, Liu D1, Li B1, Zhang M. (PubMed)
(2) The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is Mediated by CREB-BDNF Signaling Pathway by Motaghinejad M1, Motevalian M2, Fatima S2, Faraji F2, Mozaffari S. (PubMed)
(3) Metabolism and Memory: Obesity, Diabetes, and Dementia by Daniel Shalev and Melissa R. Arbuckle. (PMC)
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