The Effects of Celery on Hyper and Hypo-Thyroidism, According to Studies

Kyle J. Norton

Celery-induced decrease of thyroid hormone levels may be used as a whole food medicine to balance thyroid hormone in patients with hyperthyroidism, a renowned institute study suggested.

According to an experimental study of 40 male rats divided into 5 groups of eight rats each, rats received celery leaf extract with doses of 50 and 100 mg/kg showed serum levels of T3 (0.95±0.04 and 0.95±0.06, respectively) and T4 (5.42±0.85 and 5.87±0.89, respectively) hormones decreased compared to a control group.


Celery is a species of Apium graveolens, belonging to the family Apiaceae, cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranged in a conical shape joined at a common base.

Unfortunately, according to the joint research paper led by Shahrekord University of Medical Sciences, intake of celery may induce hyperthyroidism, as a report indicated that a 48-year-old, with no history of any thyroid diseases, was diagnosed with hyperthyroidism due to daily consumption of 4 g of dried celery leaves for 45 days.

Dr. Rouhi-Boroujeni H, the lead author said, " Hyperthyroidism may be induced by consumption celery" and " Therefore, it can be assumed that celery induces hyperthyroidism as a side effect of this herb if it is used for a long term"

Furthermore, celery has been shown to interact with conventional medicine used to regulate thyroid hormone inpatient with hypothyroidism. According to the study, in a report of a 55-year-old woman showed no improved hypothyroidism with a daily dose of thyroxine 100 micrograms after injecting celery seed tablets.

Due to conflict results, it is up to readers to consult with their herbalists, before consumption of a large amount of celery seeds supplement daily in the long term for the amelioration of hyperthyroid or hypothyroidism.


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Sources
(1) Effect of Apium Graveolens Leaf Extract on Serum Level of Thyroid Hormones in Male Rats by
wassam Kooti, akram Ahangarpoor, maryam Ghasemiboroon, sahar Sadeghnezhadi, zahra Abbasi, ziba Shanaki, zahra Hasanzadeh-Noohi, majid Asadi-Samani(Journal of Bahol University of Medical Science)
(2) Is herbal therapy safe for obesity? A case of Apium graveolens (Celery) induced hyperthyroidism.
Rouhi-Boroujeni H1, Hosseini M2, Gharipour M3, Rouhi-Boroujeni H4.(PubMed)
(3) Thyroxine interacts with celery seed tablets? by Geraldine Moses(NPS Medicinewise)

#Ashwagandha (300 mg) Improves Stress Associated with Poor Eating Behaviors, Researchers Say

Kyle J. Norton

Chronic stress is the response to emotional pressure in demanding situations over some time, leading to the release of the hormone cortisol and adrenaline.
Most common factors associated with stress incidence include psychological pressures, such as work deadlines, and exams, high-pressure jobs, and financial difficulties.

Over time unresolved chronic stress can cause a wide range of symptoms and increase the risk of developing physical and psychological syndromes, including anxiety and depression.

The most common symptoms of chronic stress are irritability, difficulty concentrating, rapid, disorganized thoughts, fatigue, headaches, feeling helpless, low self-esteem, and difficulty sleeping.

Some patients may also experience symptoms of digestive problems, changes in appetite, and loss of sexual desire.

Dr. Mohd. Razali Salleh in the examination of chronic stress in the risk of diseases wrote, "The relationship between stress and illness is complex. The susceptibility to stress varies from person to person. Among the factors that influenced the susceptibility to stress are genetic vulnerability, coping style, type of personality, and social support".

And, "Stress also alters the acid concentration in the stomach, which can lead to peptic ulcers, stress ulcers or ulcerative colitis. Chronic stress can also lead to plaque buildup in the arteries (atherosclerosis), especially if combined with a high-fat diet and sedentary living. The correlation between stressful life events and psychiatric illness is stronger than the correlation between medical or physical illness".

In other words, chronic stress if untreated can cause a wide range of chronic diseases, including psychiatric illness.

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In finding a potential compound for the treatment of chronic stress, researchers examined the effect of Ashwagandha Root Extract on obese patients with long-term stress and anxiety.

The double-blind, randomized, placebo-controlled trial included a total of 52 subjects under chronic stress who received either Ashwagandha (300 mg) or a placebo twice daily.

According to the tested differentiation at the start and at 4 and 8 weeks, including the Perceived Stress Scale and Food Cravings Questionnaire, the Ashwagandha treatment group showed a significant improvement in stress associated with poor eating behaviors, including feelings of disinhibited eating, binge eating, hunger, and more ineffective attempts to control eating.

Moreover, according to the Oxford Happiness Questionnaire, the Ashwagandha treatment group is more satisfied including body weight, and happier than the control.

No adverse effects had been reported by participants.

Based on the results, researchers wrote, "The outcome of this study suggests that Ashwagandha root extract can be used for bodyweight management in adults under chronic stress".

Taken together, Ashwagandha may be considered a remedy for the prevention and treatment of chronic stress, pending the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1)Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial by Choudhary D1, Bhattacharyya S2, Joshi K. (PubMed)
(2) Life Event, Stress, and Illness by Mohd. Razali Salleh, (PMC)

#Phenolic Compounds Found in Mixture of #Blackberry, #Fig and #Artichoke Inhibit #FreeRadicals and #LiverToxins, AQccording to Studies

Kyle J. Norton

Oxidative stress is a condition caused by the imbalance of the ratio of free radicals and antioxidants produced by the host, leading to lipid and protein damage and alternation of cell DNA.
Oxidative stress has been found to initiate the onset of chronic diseases, including heart disease, diabetes, and cancers.

Free radicals are unstable atoms with an unpaired electron in the outer ring. Therefore, in order for them to become stable, free radicals are ready to steal or donate an electron from or to other atoms, leading to a chain reaction that can not be stopped until all electrons in the outer ring are paired or inhibited by antioxidants.

The overexpression of free radicals is bad. However, free radicals generated from cell metabolism may play a critical role in the synthesis of energy and essential molecules and boosting the immune system.

Antioxidants are stable atoms that inhibit oxidation.

In a healthy individual, antioxidant enzymes by the body are more than enough to accounter the expression of free radicals that bombard our body every day.

However, in less healthy people, the intake of dietary antioxidants such as supplements or fruits rich in antioxidants may be the only option to improve levels of antioxidants in the body.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.

On finding a natural compound for the treatment of diseases associated with oxidative stress, researchers investigated artichoke antioxidant activity, compared to those of Ficus carica, and Morus nigra and their herbal mixture (CFM) in vitro, using CCl4-induced damage in HepG2 cells.

CFM at 1 mg/ml showed a 47.00% and 37.09% decline of aspartate transaminase and alanine transaminase, the oxidative stress markers, and an increase of the glutathione and superoxide dismutase 77.32% and 101.02%, the antioxidants produced by the host, comparable to CCl4 treated cells.

The antioxidant activity of fig and artichoke was attributed to the existence of different phenolic metabolites that act synergistically.

Dr. Youssef FS, the lead scientist said, "A herbal mixture composed of blackberry, artichoke, and fig could afford an excellent natural candidate to combat oxidative stress and counteract hepatic toxins owing to its phenolic compounds".


With an aim to reveal more information about the artichoke antioxidant effects, researchers launched a comprehensive evaluation of the Jerusalem artichoke (Helianthus tuberosus L.) leaf and tuber extract.

According to the results from the analysis, leaf extract exhibited a higher content of phenols and flavonoids compared to tuber extracts (5.07 and 7.14 fold higher, respectively).


The application of tuber extract at concentrations (25-500 μg·ml- 1) had a positive effect on fibroblast growth.

In the fibroblast cell line, tuber and leaf extracts increase the expression of the ROS SOD-1 inactivating enzyme gene associated with apoptotic signaling and cell death without affecting the levels of Nox-4 antioxidant activity.

Dr. Nizioł-Łukaszewska Z and colleagues, after taking into account co and confounders wrote, "Jerusalem artichoke leaves and tubers extracts affect the cell proliferation and can alter the expression of genes related to oxidative stress".


Taken together, artichoke may be considered a functional and herbal remedy for the prevention and treatment of diseases associated with overexpression of reactive oxygen species (ROS), pending the confirmation of a larger sample and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Synergistic Hepatoprotective and Antioxidant Effect of Artichoke, Fig, Blackberry Herbal Mixture on HepG2 Cells and Their Metabolic Profiling Using NMR Coupled with Chemometrics by Youssef FS1, Labib RM1, Eldahshan OA1, Singab ANB. (PubMed)
(2) Antioxidant activity and cytotoxicity of Jerusalem artichoke tubers and leaves extract on HaCaT and BJ fibroblast cells by Nizioł-Łukaszewska Z1, Furman-Toczek D1, Zagórska-Dziok M. (PubMed)

#Herbal #Andrographis Inhibits Gene Expressions and Pathways Associated with the Onset of Non Small Cell #LungCancer Whole Herb Medicine

Kyle J. Norton

Andrographis may be used as a possible therapeutic herbal medicine for the prevention and treatment of Lung cancer, a Taiwan study suggested.

Andrographis paniculata also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, and upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...

Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. Most common forms of primary lung cancers are derived from epithelial cells. In the US, Lung cancer is the leading cause of cancer deaths of 158,683 people, including 88,329 men and 70,354 women, according to 2007 statistics.

According to the National Chung Hsing University, andrographolide, one of the major diterpene lactones found in Andrographis paniculata exhibited anti-pulmonary cancer effects in a lung tumor mouse.

Dr. Tung YT, the lead author of the study said, "Andrographolide treatment on the overexpression of VEGF can arrest the cell cycle, which induced pulmonary tumors in transgenic mice".

In non-small-cell lung cancer, intake of andrographolide significantly enhanced the function of HLJ1, a novel tumor suppressor in used as a druggable target for non-small-cell lung cancer (NSCLC).

Furthermore, andrographolide also affected the gene expression involved in the cell cycle, apoptosis, and adhesion-related biological signaling, leading to inhibition of the development and progression of non-small cell lung cancer.

Another study insisted that the inhibition of andrographolide on non-small cell lung cancer (NSCLC) A549 cell migration and invasion is also attributed to other mechanisms besides gene expression, such as phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway in regulating the cell cycle, VEGF pathway in regulating of tumor angiogenesis,, etc.

There is no doubt that andrographolide may be a promising new anticancer agent used in suppressing tumor growth and invasion in NSCLC, but more studies are necessary to confirm the validation.


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Sources
(1) Therapeutic Potential of Andrographolide Isolated from the Leaves of Andrographis paniculata Nees for Treating Lung Adenocarcinomas by Tung YT1, Chen HL, Tsai HC, Yang SH, Chang YC, Chen CM. (PubMed)
(2) The HLJ1-targeting drug screening identified Chinese herb andrographolide that can suppress tumour growth and invasion in non-small-cell lung cancer by Lai YH1, Yu SL, Chen HY, Wang CC, Chen HW, Chen JJ.(PubMed)
(3) Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells by Lin HH1, Tsai CW, Chou FP, Wang CJ, Hsuan SW, Wang CK, Chen JH. (PubMed)
(4) Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway by Lee YC1, Lin HH, Hsu CH, Wang CJ, Chiang TA, Chen JH(PubMed)

#An Aqueous #Extract of Fruits of #Herbal #Ashwagandha Exerts a Significant Hypolipidemic Activity, According to Studies

Kyle J. Norton

Cholesterol produced by the liver plays an essential role in moderate amount in orchestrating the production of steroid hormone and vitamin D, building strong cell walls, and aiding the digestive system in absorbing nutrients and fluids.
Hyperlipidemia or high blood cholesterol is a medical condition characterized by abnormally high levels of lipids in the blood.

Blood cholesterol can be classified into
* The high-density lipoprotein also known as good cholesterol processes a function to return cholesterol to the liver.

* The low-density lipoprotein is also known as "bad" cholesterol processed a function aforementioned health benefits in moderate amounts.

In a healthy individual, unused cholesterol is returned to the liver. However, overexpression of "bad" cholesterol due to the consumption of a high-fat diet and reduced levels of "good" cholesterol can cause bad cholesterol to remain in the bloodstream, leading to hyperlipidemia.

The healthy ratio of total blood cholesterol ("bad"/ "good") is any number that is less than 4.

Patients with hyperlipidemia are asymptomatic. However, over time hyperlipidemia can cause plaque to accumulate on the arterial wall, leading to atherosclerosis, a major cause of heart disease and stroke.

According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL in the US.

Some researchers suggested that the hyperlipidemic prevalence in the Western world may correlate to the promotion of a high-fat diet over the past few decades.

Dr. Karam I, the lead scientist in examing said, "Hyperlipidemia, a group of metabolic disorders characterized by the elevated levels of lipids, is a major modifiable risk factor for atherosclerosis and cardiovascular disease [5]. These lipids include cholesterol, cholesterol esters, phospholipids, and triglycerides. Increased levels of LDL are related to the development of atherosclerosis [15,16].


And, "The result showed that there was a significant increase in hyperlipidemia biomarkers which includes TC, TG, LDL, and HDL. There were histological changes in organs which confirm the previous result of blood lipid. That mean a high-fat diet successfully induces hyperlipidemia in rats, to make a disease model of hyperlipidemia.".

The life-long condition of hyperlipidemia is treatable. By a change of diet and daily moderate exercise, you may control the condition without medication.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of heart disease, researchers examined the effects of Ashwagandha on lowering blood cholesterol.

The study included rats induced by a high-fat diet treated with an aqueous extract of fruits of Withania coagulans for 7 weeks.

According to the tested analysis during the experiment, administration of the extract showed a significantly reduced elevated serum cholesterol, triglycerides, and lipoprotein levels.


In triton-induced hypercholesterolemia., the aqueous extract of fruits of Withania coagulans exerted a significant hypolipidemic activity.

Furthermore, according to the tested analysis on the liver tissues of treated hyperlipidemic rats, the extracts also inhibited the degenerative changes, compared to hyperlipidemic controls.

Based on the findings, researchers said, "The hypolipidemic effect of W. coagulans fruits was found to be comparable to that of an Ayurvedic product containing Commiphora Mukul".

Taken together, Ashwagandha may be considered a functional herb for lowering blood cholesterol, pending to the result of larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hypolipidemic and antioxidant activity of aqueous extract of fruit of Withaniacoagulans (Stocks) Dunal in cholesterol-fed hyperlipidemic rabbit model by Shukla K, Dikshit P, Shukla R, Sharma S, Gambhir JK. (PubMed)
(2) Hypolipidemic activity of aqueous extract of Withania coagulans Dunal in albino rats by Hemalatha S1, Wahi AK, Singh PN, Chansouria JP. (PubMed)
(2) Induce Hyperlipidemia in Rats Using High Fat Diet Investigating Blood Lipid and Histopathology by Karam I, Ma N, Yang Y-J, and Li J-Y. (The Journal of Hematology and Blood Disorders)

#Phytochemical #Lycopene Inhibits Enzymes Associated with Chronic or Excessive Alcohol Intake-Related Liver Injury

Kyle J. Norton

Nonalcoholic fatty liver disease (NAFLD) is a medical and chronic liver condition associated with fat accumulated over time, without the presence of excessive alcohol use.
NAFLD can be classified into non-inflammatory fatty liver (NAFL) and inflammatory nonalcoholic steatohepatitis (NASH).

Untreated Nonalcoholic fatty liver disease (NAFLD) has been found to induce cirrhosis, a major cause of liver cancer.

According to world statistics, nonalcoholic fatty liver disease (NAFLD) is normally known as a disease in the Western world. However, today, due to the economic prosperity of Southeast Asia over the past few decades,, the disease also was found in a large number of populations in the cities, causing concerns of many scientists in the region.

The prevalence rate of non-alcoholic fatty liver disease (NAFLD) among the more affluent regions of China, is approximately 15%. The number may decrease substantially if the poor rural populations where obesity is non-existence are also taken into account.

In the US, over 100 million people have non-alcoholic fatty liver disease and the condition is more doubled over the past 20 years. Today, the disease also is also prevalent in liver disease in children.

Most people at the early stage of NAFLD are asymptomatic. However, as the disease progresses into the later stage, most patients experience symptoms of right upper abdominal discomfort, fatigue, and/or malaise, and jaundice(20) with yellowing of the skin and eyes.

The exact causes of NAFLD are not identified. Some researchers suggested that certain risk factors such as long-term use of certain medications, genetic preposition, insulin resistance, high cholesterol and triglycerides, polycystic ovary syndrome, metabolic syndrome, obesity, and type 2 diabetes are associated with the onset of the disease.

Some researchers suggested that an unhealthy diet such as the promotion of a high-fat diet in the Western world over the last few decades may also have a strong implication on NAFLD.


Dr. Jensen VS, the lead scientist in the study of high-fat diet-induced non-alcoholic fatty liver disease, wrote, "In humans and animal models, excessive intake of dietary fat, fructose, and cholesterol have been linked to the development of non-alcoholic fatty liver disease (NAFLD)".

And, " Only HFr-fed rats developed dyslipidemia as characterized by higher levels of plasma triglycerides compared to all other groups (p < 0.0001). Hepatic dysfunction and inflammation were confirmed in HFD-fed rats by elevated levels of hepatic MCP-1 (p < 0.0001), TNF-alpha (p < 0.001), and plasma β-hydroxybutyrate (p < 0.0001), and in NASH-fed rats by elevated levels of hepatic MCP-1 (p < 0.01), increased hepatic macrophage infiltration (p < 0.001), and higher plasma levels of alanine aminotransferase (p < 0.0001) aspartate aminotransferase (p < 0.05), haptoglobin (p < 0.001) and TIMP-1 (p < 0.01) compared to Control".

Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In finding a potential compound for the prevention of alcoholic fatty liver disease, researchers evaluated the effect of lycopene (LYC) on chronic or excessive alcohol intake-related liver injury.

Lycopene inhibited the expression of cytochrome P450 2E1 (CYP2E1) enzyme associated with chronic and excessive alcoholic drinking.

Where cytochrome P450 2E1(CYP2E1) not only represents the major enzymes in the CNS that catalyze ethanol oxidation but also plays a vital role in alcohol, drug, toxin, lipid, and carcinogen metabolism associated with reactive oxygen species-induced oxidative stress that promotes hepatocyte injury and death.

In other words, excessive alcohol drinking induced the production of free radicals that lead to liver damage in the initiation of inflammation, fibrosis, and lipid peroxidation.

More precisely, lycopene prevented liver injury in the induction of alcoholic fatty liver disease by targeting the expression of CYP2E1 induction.


Taken together, lycopene found in tomatoes may be considered supplements for the prevention and treatment of alcoholic fatty liver disease, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene Improves Diet-Mediated Recuperation in Rat Model of Nonalcoholic Fatty Liver Disease by Piña-Zentella RM1, Rosado JL1, Gallegos-Corona MA2, Madrigal-Pérez LA3, García OP1, Ramos-Gomez M. (PubMed).
(2) Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development by Stice CP1, Xia H1, Wang XD. (PubMed)
(3) The Herbal Medicines Which Treat Non-Alcoholic Fatty Liver Disease (NAFLD) Naturally, According to Studies by Kely J. Norton

#Herbal #Ashwagandha #Extract Promotes Proteins and Pathways Associated with a Reduced Risk of #Glioblastoma, Researchers Say

Kyle J. Norton

Primary glioblastoma is one of the most aggressive cancers that begins within the brain. Cancer may arise as a Grade IV tumor with no evidence.

According to the statistic, the median survival time of primary glioblastoma is approximately 3 months without medical treatment. Glioblastomas represent about 15% of all primary brain tumors.

In the US, the median age of glioblastoma diagnosed is 64 years and the incidence of the disease onset is 1.6 times higher in males compared to females.

Furthermore, the condition is 2 times higher in Caucasians compared to Africans and Afro-Americans.

Because of the rapid growth, patients diagnosed with primary glioblastoma experience sudden brain swelling and increased brain pressure, leading to symptoms of nausea, vomiting, severe headaches, and localized symptoms depending on the location of the tumor.

Conventionally, radiation and chemotherapy are the most common forms of treatment for patients with glioblastoma particularly, in a tumor that cannot be removed with surgery.

The causes of glioblastoma are not identified. However, the increase in age and genetic preposition are the 2 most common risk factors found in patients with the disease.


Dr. Athanassios P. Kyritsis, the concern about the rapid progression of glioblastoma, wrote, "Scientific evidence during the last few years has revealed several constitutive genetic abnormalities that may influence glioma formation".

And, "These germline abnormalities are manifested as either gene polymorphisms or hemizygous mutations of key regulatory genes that are involved either in DNA repair or in apoptosis".

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belongings to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In finding a potential compound for the treatment of gliomas, the type of primary brain tumor in adults, researchers examined the effects of Withania somnifera (ashwagandha) on neuronal cell lines.

In vitro, ashwagandha water extract (ASH-WEX) showed a strong cell cycle arrest in the G2/M phase by activating multiple pro-apoptotic pathways associated with genes in the suppression of cells progression and proliferation, such as cyclin D1, bcl-xl, and p-Akt.

Furthermore, the expression of the polysialylated form of neural cell adhesion molecule (PSA-NCAM) and matrix metalloproteinases that promote neural plasticity and tumor malignancy was also inhibited by the administration of the extract.


Moreover, in vivo, ASH-WEX also suppressed the tumor-promoting proteins such as vascular endothelial growth factor (VEGF) and heat shock protein 70 (HSP70) and exerted the aforementioned effects in the rat model of orthotopic glioma allograft.


Additionally, the extract not only inhibited the reduction in glial fibrillary acidic protein (GFAP) and upregulation of mortal associated with cancer malignancy and poor prognosis but also blocked neural cell adhesion molecule (NCAM) expression in tumor-bearing tissue involved cancer cell proliferation, motility, and migration.

Based on the findings, researchers said, "ASH-WEX in glioma with in vivo model system offers new opportunities to develop a therapeutic strategy for safe, specific, and effective formulations for treating brain tumors".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and treatment of glioblastoma, pending the confirmation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withaferin A and its potential role in glioblastoma (GBM) by Dhami J1, Chang E2, Gambhir SS. (PubMed)
(2) Withania somnifera Suppresses Tumor Growth of Intracranial Allograft of Glioma Cells by Kataria H1,2, Kumar S1, Chaudhary H1,2, Kaur G. (PubMed)
(3) Chapter 8Epidemiology and Outcome of Glioblastoma by Ahmad Faleh Tamimi and Malik Juweid (NCBI)
(4) Inherited predisposition to glioma by Athanassios P. Kyritsis, Melissa L. Bondy, Jasti S. Rao, and Chrissa Sioka. (PMC)