#Phytochemical 3,3'-Diindolylmethane Protects Your Bone Against #Osteoporosis by Reducing the Bone Resorption Parameters, Reserachers Suggest

Kyle J. Norton

Osteoporosis is a medical condition characterized by loss of bone density over time, caused by overexpression of bone loss compared to bone made.

In other words, osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time, leading to an increased risk of fracture.

The most common fractures that occurred in patients with OP are the hip, spine, wrist, and shoulder.
Most people with a risk of fracture do not know they have osteoporosis until the disease has advanced to the advanced stage.

Researchers do not know the exact causes of osteoporosis. Neither do they know why some people with the same health condition in the same family, are prone to the condition, while others do not.

However, according to epidemiological studies, young age at diagnosis, male sex, aging, race, family history, body size, decreased lean mass, smoking and use of growth hormone replacement are some of the prevalent factors found in most patients with osteoporosis.

The most common symptoms of osteoporosis are loss of height over time, back pain, a stooped posture, neck, and low back pain, particularly bone break easily.

Recently, some scientists suggested that osteoporosis may also be associated with long-term consumption of a poor diet.

Dr. Seon-Joo Park in the investigation of dietary patterns and osteoporosis risk wrote, "Three major dietary patterns were identified using factor analysis based on baseline intake data: traditional (high intake of rice, kimchi, and vegetables), dairy (high intake of milk, dairy products, and green tea), and western (high intake of sugar, fat, and bread)".

And, ".., Western dietary pattern (p-trend = 0.043 in radius) demonstrated a higher risk of osteoporosis incidence than those in the lowest quintile".

These results strongly suggested if you are a Western diet follower, your risk of osteoporosis is increased substantially compared to other healthy diet pattern followers.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.

In finding the natural compound for the treatment of osteoporosis, researchers investigated the effect of DIM on bone mass in mice under physiological and pathological conditions.

The study included 8-week-old female mice who received injections of a vehicle or 0.1mg/g of DIM, twice a week for four weeks.

According to the dual-energy X-ray absorptiometry (DEXA) and micro-computed tomography (μCT) analysis, DIM treatment significantly increased bone mass.

Interestingly, treatment of DIM was found to significantly reduce bone resorption parameters but did not increase bone formation parameters.

In the ovariectomized (OVX)-induced osteoporotic mouse model, the administration of DIM effectively prevented OVX-induced bone loss resulting from increased bone resorption.

In other words, DIM increased bone mass by suppressing osteoclastic bone resorption in bone metabolism under both physiological and pathological conditions.


The results strongly suggested that DIM protects bone integrity against the onset of osteoporosis in vivo and in vitro.

Dr. Yu TY, the lead researcher, after taking other factors into account said, "DIM may be of value in the treatment and the possible prevention of bone diseases characterized by bone loss, such as postmenopausal osteoporosis".

Taken together, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of osteoporosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic boneresorption in mice by Yu TY1, Pang WJ2, Yang GS. (PubMed)
(2) Dietary Patterns and Osteoporosis Risk in Postmenopausal Korean Women by Seon-Joo Park, Seong-Eun Joo, Haesook Min, Jae Kyung Park, Yeonjung Kim, Sung Soo Kim, and Younjhin Ahn. (PubMed)

#Phytochemical #Alliin Balances the Ratio of Gut Microbiota by Inhibiting Ethanol Absorption and Accelerating Athanol Metabolism

Kyle J. Norton

Inflammation is a natural response of the immune system with an aim to protect our body against foreign micro pathogens which may infect the body tissue.

In the early phase of infection, after receiving the message from the central nervous system, the white blood cells of the immune first-line defense macrophages stimulate the production of blood palette to cover the site of tissue damage and injury and inflammatory cytokines to destroy the microorganisms which try to enter the body through the wound.


Depending on the size of the injury, most small tissue damages are healed by itself within a day or weeks. In some cases, stitches may be needed.

However, if the immune system can not drive out all the invaders in a period of 3-8 weeks, it will compromise, leading to low-grade inflammation.

Over time, long-term low-grade inflammation may cause tissue damage and alternation of cell DNA, leading to chronic diseases such as cardiovascular disease, diabetes, and cancer.

Gut microbiota is a community of bacteria found in the gut. In a healthy individual, the ratio of good and bad bacterias are balanced. However, if the bad bacteria are overgrowing compared to good bacteria, it may lead to dysbiosis which has been found to induce chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism.

The most common risk factors associated with the imbalanced ratio of gut microbiota include the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle.

In other words, if you follow a healthy diet with a high in vegetables and fruits and fewer in processed foods, saturated and trans fat, and red meat accompanied by moderate exercise, you may have done a job to protect the balance of gut microbiota.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belongings to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a potential compound for the protection of gut microbiota, researchers examined the effect of alliin (S-allyl-L-cysteine sulfoxide (ACSO)) on plasma ethanol concentration due to alcohol intake by accelerating ethanol metabolism and preventing ethanol absorption from the gut in rats.

Injection of high ACSO content (Garlic-H) suppressed elevation in concentrations of ethanol and acetaldehyde in plasma in the experimental rats without affecting much of the plasma acetate.

Furthermore, the inhibition of alcohol ethanol was attributed to the activity of alliin in the promotion of the activities of alcohol dehydrogenase and aldehyde dehydrogenase, a group of enzymes that catalyze the oxidation of aldehydes.

Compared to the absorption of ethanol from the stomach and jejunum, alliin ACSO and Garlic-H suppressed the absorption of ethanol from the stomach and jejunum, but the suppression in the jejunum was less than in the stomach.

In other words, alliin protects the gut microbiota by inhibiting ethanol absorption and accelerating ethanol metabolism.

In dextran sulfate sodium (DSS)-induced colitis mice and lipopolysaccharide-stimulated RAW264.7 cell model, oral administration of alliin at 500 mg/kg significantly inhibited the decrease of body weight, improved the DAI and decreased the infiltration of inflammatory cells in colonic tissues.

The levels of pro-inflammatory expressions and pro-inflammation activation proteins in the gut and the content of NO, MDA, and MPO of gut stress markers were also inhibited by the injection of alliin.

Based on the findings, researchers wrote, "Our results show that alliin ameliorates DSS-induced ulcerative colitis and inhibits the inflammatory responses in LPS-stimulated RAW264.7 cells partly".

Taken together, alliin may be considered a supplement for the prevention and treatment of gut microbiota imbalanced as seen in colitis patients, pending the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) S-Allyl-L-cysteine sulfoxide, a garlic odor precursor, suppresses elevation in blood ethanol concentration by accelerating ethanol metabolism and preventing ethanol absorption from the gut by Uto-Kondo H1, Hase A2, Yamaguchi Y2, Sakurai A2, Akao M2, Saito T3, Kumagai H. (PubMed)
(2) Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation by Shi L1, Lin Q1, Li X2, Nie Y1, Sun S1, Deng X3, Wang L1, Lu J1, Tang Y1, Luo F. (PubMed)

#PurifiedFruitBromelain (PFB), Suppresses the Risk of Colitis through Its Anti-Inflammatory Activity, Researchers Suggest

Kyle J. Norton

Colitis is a medical condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.
Depending on the type of colitis, the most common prevalent factors found in patients with such as condition are.
* Familial history of inflammatory bowel disease (odds ratio (OR) 4.3)

* Breastfeeding (OR 2.1)

* Bacille Calmette-Guerin vaccination (OR 3.6 )

* History of eczema (OR 2.1 (1-4.5))

* Disease during pregnancy (OR 8.9 (1.5-52)), and

* Bedroom sharing (OR 7.1 (1.9-27.4))

* Crohn's disease both appendectomy and tonsillectomy have positive associations. Well-established

* Smoking status

* If you are over 50, you are at increased to develop colitis.

And * Depression and psychosocial stress, according to the basis of data from the Nurses' Health Study, increase the risk for CD, but not UC, among women. Psychological factors might have been found to induce CD development.

Furthermore, patients with medicals condition such as hypertension, diabetes, hyperlipidemia, and atrial fibrillation are associated with increased risk to develop ischemic colitis(IC), according to the study by Beijing Hospital, Ministry of Health.

Believe it or not, regular drinking of tap water was a protective factor and ulcerative colitis appendicectomy was a protective factor.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a potential compound for the treatment of colitis, researchers examined the effects of bromelain on the inflammatory response that lead to the onset of colitis.

In epithelial TNFR in rats colitis induced by the intracolonic administration of 2, 4, 6-trinitrobenzene sulfonic acid, injection of purified fruit bromelain (PFB) significantly decreased the increased expression of TNFR1 and TNFR2.

Where TNF-α receptor (TNFR) is a proinflammatory cytokine activated by the immune response.

Furthermore, typical symptoms associated with colitis such as infiltration of inflammatory cells, cytokine profiles, epithelial cell apoptosis, and epithelial tight junction barrier dysfunction were significantly ameliorated by PFB.


According to the chemical analysis, fruit bromelain showed a superior inhibition of TNFR2 than that exhibited on TNFR1 compared to those of stem bromelain complex.

In other words, PFB expressed its anti-inflammatory activity by blocking the activation of high expression of epithelial TNFRs.


Based on the findings, researchers said, "PFB-induced TNFR inhibition ameliorated colitis symptoms. These results supply novel insights into potential IBD treatment by PFB".

In other to reveal more information on bromelain anti-colitis effects, researchers evaluated the long-term dietary supplementation with pineapple (supplied as juice) in decreasing colon inflammation and neoplasia in Il10(-/-) mice with chronic colitis as compared with bromelain derived from the stem.

Colitis triggered in Il10(-/-) mice by exposure to the non-steroidal anti-inflammatory drug piroxicam for 6 months showed decreased histologic colon inflammation scores and lower incidence of inflammation-associated colonic neoplasia (35% versus 66%; P < 0.02), with fewer neoplastic lesions/colon (P = 0.05) after receiving treatment of fresh juice.

According to the tested assays, fresh pineapple juice demonstrated proteolytic activity in removing cell surface molecules that can affect leukocyte response.

Dr. Hale LP, the lead scientist wrote in the final report, "Long-term dietary supplementation with fresh or unpasteurized frozen pineapple juice with proteolytically active bromelain enzymes is safe and decreases inflammation severity and the incidence and multiplicity of inflammation-associated colonic neoplasia in this commonly used murine model of inflammatory bowel disease".

Taken together, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of colitis associated with inflammatory bowel disease, pending the confirmation of the larger sample size and multicenter human study.


Intake of bromelain in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis by Hale LP1, Chichlowski M, Trinh CT, Greer PK. (PubMed)
(2) Inhibition of Epithelial TNF-α Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis by Zhou Z1, Wang L1, Feng P1, Yin L2, Wang C3, Zhi S3, Dong J1, Wang J1, Lin Y2, Chen D1, Xiong Y4,5, Peng J. (PubMed)
(3) Colitis - The Risk Factors by Kyle J. Norton

#Bilberry Inhibits Cytotoxicity and Neuro-Toxicity Against the Onset of #Cancer and #Alzheimer's diseases, Scientists Say

Kyle J. Norton

Cytotoxicity is a process or action that destroys the living cells, through activating the production of pro-inflammatory cytokines and proteins associated with cell apoptosis and programmed cell death.
Free radical cytotoxicity is the ability of ROS in exerting oxidative stress in the cancer cells, leading to apoptosis.

Cancer is a class of diseases characterized by irregular cell growth due to DNA alternation.

Most cancers do not cause any symptoms at an early stage. However, at the later stage, a larger size of the tumor can press on the nearby blood vessels and nerve cells, causing localized bleeding and severe pain.

The most common symptoms of cancer are unintended weight loss, loss of appetite, fatigue or tiredness, and gastrointestinal discomforts and symptoms depending on the location of the cancer.


If you experience some of the above symptoms, please check with your doctor to rule out the p[ossibility of the disease.

The causes of cancer are unknown. Researchers can not explain why people with the same health conditions, and family history in the same family, are susceptible to cancer, while others do not.

In normal cells, overproduction of free radicals or oxidative stress can affect the cell lipid, protein, leading to cell damage or alteration of cell DNA.

Most cases of natural remedies initiating the cytotoxic effects against cancer without causing nearby healthy cell death probably are associated with the stimulation of the production of antioxidants produced by the host and the presence of antioxidants in the remedy.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

Researchers on finding a natural compound with cytotoxic potency examined the bilberry chemical compound in facilitating the onset of cytotoxicity against cancer and neutralizing the neuro cytotoxicity against the formation of plague on K562 Human Erythroleukemic cancer cells and Alzheimer's diseases (AD), respectively.

GroES self-assembled into amyloid fibrils similar to those observed in various neurodegenerative diseases was found to induce cell toxicity.

Before the application of bilberry anthocyanins, injection of soluble intermediate aggregates of GroES exhibited neuronal cell death, rather than forming mature fibrils.

Pretreatment with anthocyanins isolated from bilberry, not only inhibited both fibril formation but also neutralized the toxicity of intermediates.

The findings strongly suggested anthocyanins processes an inhibitory effect on the amyloid fibril formation of various conformational disease-causing proteins.

Oppositely, in cancer perspective, anthocyanins stimulated the tumor suppressor genes to induce apoptosis in cancer cells.


Dr. Seth P. Thibado and colleagues in the study to enhance the chemical compound bioavailability, observed the cytotoxicity of anthocyanins in an encapsulated in 5.5 nm diameter liposomal micelles, called NutraNanoSpheres (NNS), at a concentration of 2.5 mg/50 µl [25% (w/w) anthocyanins].


Bilberry NNS induced the apoptotic/cytotoxic effects on K562 Human Erythroleukemic cancer cells.

The concentrations of bilberry demonstrated the greatest levels of percentage inhibition of 60–70% at 0.018–1.14 mg/ml (n=6) and 60% inhibition at 4 mg/ml, compared to control.

And, the lowest percentage of inhibition (30%) occurred at 2 mg/ml. The lethal dose 50 was determined to be 0.01–0.04 mg/ml of Bilberry per 105 K562 cells at 72 h of cell culture exposure.

At 48 h incubation, the highest percentage of inhibition was only 27%,.

The findings clearly suggested that NutraNanoSpheres (NNS) demonstrates direct cytotoxic effects, at a concentration which is 8–40 times lower than the levels required for bilberry if not encapsulated.

Taken altogether, bilberry processed abundantly bioactive ingredient anthocyanins may be considered a functional remedy in modulation the cytotoxic activity against cancer, pending to the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bilberry anthocyanins neutralize the cytotoxicity of co-chaperonin GroES fibrillation intermediates by Iwasa H1, Kameda H, Fukui N, Yoshida S, Hongo K, Mizobata T, Kobayashi S, Kawata Y. (PubMed)
(2) Anticancer effects of Bilberry anthocyanins compared with NutraNanoSphere encapsulated Bilberry anthocyanins by Seth P. Thibado,1 Jerry T. Thornthwaite,2 Thomas K. Ballard,2 and Brandon T. Goodman. (PMC)

#Ginger Shows a Reduction of Pain and Disability in Patients with #Osteoarthritis

Kyle J. Norton

Ginger may have a potential and positive effect in ameliorating the symptoms of pain and complication of reduced quality of life in patients with osteoarthritis, some scientists suggested.

Osteoarthritis (OA) is a chronic condition a type of joint disease characterized by the breaking down of joint cartilage and underlying bone due to “wear and tear” of joints over time.

Some researchers suggested that OA is a degenerative disease characterized by “low-grade inflammation” in cartilage and synovium, affecting the joint structure and progressive deterioration of cartilage.

According to the statistic from the NIH, osteoarthritis (OA) is the most common joint disorder in the US. Among adults, 60 years of age or older the prevalence of symptomatic knee and sadly OA affects approximately 10% of men and 13% of women.

Epidemiological strongly suggested that obese and overweight have a strong impact on weight-bearing joints, the genetic preposition of a patient can make such a patient more susceptible to the disease compared to others who do not, and people with a joint injury that did heal properly in the younger age and people with occupations that require standing for long periods of time, repetitive bending, heavy lifting or other movements and the increase in age are associated to the increased risk of the onset of the disease.

The most common symptoms of osteoarthritis are joint pain and stiffness.

Dr. Giuseppe Musumeci, the lead author in the study "Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression" suggested that besides the risk factors mentioned above, dietary factors also play an important role in the onset of the disease.

In the dietary aspect of the induction of OA, the research team wrote, "This diet (The Western diet) is mainly constituted by preservative and harmful substances, such as animal fat and glucose excessive concentration and lack of nutritional factors, such as vitamins and nutrient minerals essential for our body. Moreover, bad dietary habits may predispose people to obesity, which is responsible for both metabolic destroying processes affecting the cartilage and overload of the joints, especially hips and knees".

And, " quantity and quality of nutrient intake. Low intake of vitamin D and vitamin C is a possible risk factor for knee OA, while certain food groups, such as milk and dairy products, meat and poultry are beneficial for knee OA. Thus we could affirm that nutritional imbalance, combined with endocrine abnormalities, may be involved in the pathogenesis of OA".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to reaffirm the traditional use of ginger for the treatment of osteoarthritis, a joint review led by the Copenhagen University Hospital, Bispebjerg, and Frederiksberg was conducted to assess the clinical efficacy and safety of oral ginger for the symptomatic treatment of osteoarthritis (OA).

The study was carried out by searching the randomized controlled trials (RCTs) comparing oral ginger treatment with a placebo in OA patients aged >18 years who satisfied the predetermined guidelines and criteria, including the outcomes of the reduction in pain and disability.

Out of 122 retrieved references, 117 were discarded, and only 5 five trials (593 patients) were selected for meta-analyses.

All 5 remaining studies suggested that ginger intake scored a statistically significant pain reduction.


Furthermore, the application of ginger in subjects with osteoarthritis demonstrates a statistically significant reduction in disability compared to control.


However, according to the returned questionnaires from the participants, researchers surprisingly found that patients given ginger are more than twice as likely to discontinue treatment compared to placebo.


Dr. Mozaffari-Khosravi H, the lead author, launched a joint study to determine ginger powder effects in relieving pain and inflammation in patients with osteoarthritis.

120 participants selected for the randomized double-blind placebo-controlled 3-month clinical trial for knee osteoarthritis were randomly assigned to one of two groups: the ginger group (GG) or the placebo group (PG).

Ginger selected group was given capsules containing 500 mg of ginger powder, while the PG group was given capsules filled with 500 mg of starch.

At the baseline, proinflammatory cytokine concentrations did not differ by group, observed by the participant's blood sample.

After 3 months, GG showed a significant reduction of cytokines compared to PG.

In the final report, the research team wrote, "Ginger supplementation may have promising benefits for knee osteoarthritis".

These results reconfirm the use of ginger for the treatment of osteoarthritis in traditional medicine with no side effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To ProfessionalsPrediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials by Bartels EM1, Folmer VN2, Bliddal H2, Altman RD3, Juhl C4, Tarp S2, Zhang W5, Christensen R. (PubMed)
(2) Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial by Mozaffari-Khosravi H1,2, Naderi Z1, Dehghan A3, Nadjarzadeh A1, Fallah Huseini H. (PubMed)
(3) Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression by Giuseppe Musumeci,1,* Flavia Concetta Aiello,1 Marta Anna Szychlinska,1Michelino Di Rosa,2 Paola Castrogiovanni,1 and Ali Mobasheri. (PubMed)

#BlackBean Inhibits Liver Toxicity Associated with the Onset of #ChronicLiverDisease, Researchers Show

Kyle J. Norton

Compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending on the stage of the treatment which directly addresses the cause of the disease.
Intake of black beans regularly may have a profound effect in reducing the risk and treatment of liver cancer, a renowned institute study proposed.

Liver cancer is a condition of the abnormal growth of the cells in the liver's tissue.

According to statistics approximately 40,710 adults (29,200 men and 11,510 women) in the United States will be diagnosed with primary liver cancer this year.

The exact causes of liver cancer. However, researchers believed that age, gender, excessive use of alcohol, obesity, are ethnicity are associated with the increased risk of liver cancer.

Furthermore, gene mutation such as inherited metabolic diseases is also considered as the major prevalent risk factor of liver cancer onset.

More importantly, certain chronic diseases, such as diabetes, infection by hepatitis virus, liver diseases, including cirrhosis, and non-alcoholic fatty liver disease chemical toxins and long-term use of certain medications such as acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs) aspirin, also have the potential to increased risk of liver cancer.

Besides sharing the general symptoms of cancers, patients with liver cancer also experience symptoms of upper abdominal pain and swelling, yellow discoloration of the skin, jaundice,.... and chalky stool.

If you have some of the above symptoms, please check with your doctor to rule out the possibility.

Black bean, small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae.

The legume can be bought in most grocery stores all around the year in dried and canned forms.

It is believed that black bean was the first domesticated growth in South America.

According to Stocking Hall, Cornell University, phytochemicals isolated from black beans such as triterpenoids, flavonoids, and other compounds exhibited antiproliferative activities against the HepG2 cells, the human liver cancer cell line.

The efficacy of black beans on the ameliorated growth of liver cancer may be attributed to the presence of some potent antioxidants in the expression of apoptosis.

Additionally, the consumption of beans not only played a prominent role in gene expression involving the regulation of gene Hspa8 on reduced risk of liver disease but also addressed the important issue of attenuating hepatic stress or toxicity in the rat model.

In fact, increased bean consumption in rats exhibits changes in the hepatic damage caused by liver toxicity. Dr. Daniell EL, the lead author said, "Dry bean (Phaseolus vulgaris L.) consumption is associated with reduced risk for a number of chronic diseases", such as liver cancer.

More interestingly, dietary bean concentrations.is found to associate with the cholesterol 7α hydroxylase and UDP-glucuronosyltransferase genes increased with a connection to the development of liver cancer, in a dose-dependent manner.

These findings suggested that dietary black(dried) beans may have a potential effect in reducing the risk and treatment of liver cancer through antioxidant activity and regulated genes involved early onset of the disease.

However, further data collection on large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of black bean anti-liver cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phytochemicals of black bean seed coats: isolation, structure elucidation, and their antiproliferative and antioxidative activities by Dong M1, He X, Liu RH. (PubMed)
(2) Dietary dry bean effects on hepatic expression of stress and toxicity-related genes in rats by Daniell EL1, Ryan EP, Brick MA, Thompson HJ. (PubMed)

#Beet or #Beetroot Reduces the Risk of Inflammatory Bowel Disease Through Its Antioxidant Activity

Kyle J. Norton

Beet or Beetroot may have a potential effect in ameliorating the abnormal function of white blood cells such as neutrophils in reduced risk and treatment of inflammatory bowel disease.
Inflammation is a natural process of immune defense to remove injurious agents, cells, and tissues from the body.

Inflammatory bowel disease is the border term of conditions characterized by chronic inflammation of the intestines, including ulcerative colitis and Crohn's disease.

Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

According to the Poznan University of Medical Science, beetroot (Beta vulgaris var. rubra) products and their major component, betanin exhibited antioxidant activities against abnormal neutrophils in modulated reactive oxygen species (ROS) production and DNA damage, in healthy subjects.

The efficacy of betanin in reduced reactive oxygen species (ROS) expression is the result of exerting antioxidant free radical scavenging and neutralizing activities by slowing down or preventing the initiation of free radical chain reactions.

Additionally, betanin, as a major phytochemical also ameliorated the elevated ROS expression in promoted oxidative stress which was found to have a strong implication to cause cellular DNA damage. Some researchers suggested that betanin reduced the risk of cellular DNA damage. probably through inter-influenced the pro-apoptotic caspase-3 in the action of the release of ROS and apoptotic cell death.

Indeed, activities of betanin in the attenuated risk of overexpression of ROS in the induction of DNA also may be an extrinsic way for the phytochemical in exerting anti-inflammatory and potentially cancer-preventive activity.


Further analysis and taking into account other confounders, researchers once again indicated that betanin with a concentration of 100 μM for 24 h, inhibited pro-inflammatory expression in ulcerative colitis (UC) and Crohn's disease (CD) patients by protecting the digestive tract that can be observed through action in decreased oxidative DNA damage and promoted apoptosis in neutrophils.

In fact, betaine and other phytochemical baicalein have been shown to provide various health benefits to an organism in many ways, including down-regulation of inflammation against colitis-associated colon tumorigenesis in the tested animals.

In the case of anti-inflammation, both betaine and baicalein were also found to demonstrate a magnificent impact in the regulation of the pro-inflammatory cytokines such as IL-1β, PGE2, and TNF-α in NF-ĸB activation besides activities in the inhibited expression of ROS.

Interestingly, in patients with ulcerative colitis, arabino-oligosaccharides (AOS) derived from sugar beet pulp, stimulated Bifidobacterium spp. and Lactobacillus spp. accompanied by a high production of acetate in eliciting anti-inflammatory responses, thus attenuating inflammatory conditions in UC patients.

The observation illustrated that beet may have the potential in acting as prebiotic to enhance the growth of beneficial microorganisms in the intestines, thus reducing the risk of flare-ups in UC patients.

Furthermore, arabinose-oligosaccharides (AOS) also showed to elevate the failure of local anesthesia in inflamed tissues through lowering of intestinal pH

The findings of improved antioxidants in attenuated free radicals in the induction of DNA and promotion of abnormal expression of neutrophils, as well as acting as a prebiotic suggested that beet may be considered as a functional food in reduced risk of chronically digestive inflammatory diseases, particularly in inflammatory bowel disease.

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Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel diseasepatients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W1.(PubMed)
(2) Modulation of Colitis-associated Colon Tumorigenesis by Baicalein and Betaine by Kim DH1, Sung B1, Chung HY1, Kim ND1.(PubMed)
(3) In vitro fermentation of sugar beet arabino-oligosaccharides by fecal microbiota obtained from patients with ulcerative colitis to selectively stimulate the growth of Bifidobacterium spp. and Lactobacillus spp by Vigsnæs LK1, Holck J, Meyer AS, Licht TR.(PubMed)
(4) Anti-inflammatory activity of baicalein in LPS-stimulated RAW264.7 macrophages via estrogen receptor and NF-κB-dependent pathways by Fan GW1, Zhang Y, Jiang X, Zhu Y, Wang B, Su L, Cao W, Zhang H, Gao X.(PubMed)