Kyle J. Norton
Colitis is a medical condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.
Depending on the type of colitis, the most common prevalent factors found in patients with such as condition are.
* Familial history of inflammatory bowel disease (odds ratio (OR) 4.3)
* Breastfeeding (OR 2.1)
* Bacille Calmette-Guerin vaccination (OR 3.6 )
* History of eczema (OR 2.1 (1-4.5))
* Disease during pregnancy (OR 8.9 (1.5-52)), and
* Bedroom sharing (OR 7.1 (1.9-27.4))
* Crohn's disease both appendectomy and tonsillectomy have positive associations. Well-established
* Smoking status
* If you are over 50, you are at increased to develop colitis.
And * Depression and psychosocial stress, according to the basis of data from the Nurses' Health Study, increase the risk for CD, but not UC, among women. Psychological factors might have been found to induce CD development.
Furthermore, patients with medicals condition such as hypertension, diabetes, hyperlipidemia, and atrial fibrillation are associated with increased risk to develop ischemic colitis(IC), according to the study by Beijing Hospital, Ministry of Health.
Believe it or not, regular drinking of tap water was a protective factor and ulcerative colitis appendicectomy was a protective factor.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential compound for the treatment of colitis, researchers examined the effects of bromelain on the inflammatory response that lead to the onset of colitis.
In epithelial TNFR in rats colitis induced by the intracolonic administration of 2, 4, 6-trinitrobenzene sulfonic acid, injection of purified fruit bromelain (PFB) significantly decreased the increased expression of TNFR1 and TNFR2.
Where TNF-α receptor (TNFR) is a proinflammatory cytokine activated by the immune response.
Furthermore, typical symptoms associated with colitis such as infiltration of inflammatory cells, cytokine profiles, epithelial cell apoptosis, and epithelial tight junction barrier dysfunction were significantly ameliorated by PFB.
According to the chemical analysis, fruit bromelain showed a superior inhibition of TNFR2 than that exhibited on TNFR1 compared to those of stem bromelain complex.
In other words, PFB expressed its anti-inflammatory activity by blocking the activation of high expression of epithelial TNFRs.
Based on the findings, researchers said, "PFB-induced TNFR inhibition ameliorated colitis symptoms. These results supply novel insights into potential IBD treatment by PFB".
In other to reveal more information on bromelain anti-colitis effects, researchers evaluated the long-term dietary supplementation with pineapple (supplied as juice) in decreasing colon inflammation and neoplasia in Il10(-/-) mice with chronic colitis as compared with bromelain derived from the stem.
Colitis triggered in Il10(-/-) mice by exposure to the non-steroidal anti-inflammatory drug piroxicam for 6 months showed decreased histologic colon inflammation scores and lower incidence of inflammation-associated colonic neoplasia (35% versus 66%; P < 0.02), with fewer neoplastic lesions/colon (P = 0.05) after receiving treatment of fresh juice.
According to the tested assays, fresh pineapple juice demonstrated proteolytic activity in removing cell surface molecules that can affect leukocyte response.
Dr. Hale LP, the lead scientist wrote in the final report, "Long-term dietary supplementation with fresh or unpasteurized frozen pineapple juice with proteolytically active bromelain enzymes is safe and decreases inflammation severity and the incidence and multiplicity of inflammation-associated colonic neoplasia in this commonly used murine model of inflammatory bowel disease".
Taken together, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of colitis associated with inflammatory bowel disease, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis by Hale LP1, Chichlowski M, Trinh CT, Greer PK. (PubMed)
(2) Inhibition of Epithelial TNF-α Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis by Zhou Z1, Wang L1, Feng P1, Yin L2, Wang C3, Zhi S3, Dong J1, Wang J1, Lin Y2, Chen D1, Xiong Y4,5, Peng J. (PubMed)
(3) Colitis - The Risk Factors by Kyle J. Norton
Saturday, 12 August 2023
#Bilberry Inhibits Cytotoxicity and Neuro-Toxicity Against the Onset of #Cancer and #Alzheimer's diseases, Scientists Say
Kyle J. Norton
Cytotoxicity is a process or action that destroys the living cells, through activating the production of pro-inflammatory cytokines and proteins associated with cell apoptosis and programmed cell death.
Free radical cytotoxicity is the ability of ROS in exerting oxidative stress in the cancer cells, leading to apoptosis.
Cancer is a class of diseases characterized by irregular cell growth due to DNA alternation.
Most cancers do not cause any symptoms at an early stage. However, at the later stage, a larger size of the tumor can press on the nearby blood vessels and nerve cells, causing localized bleeding and severe pain.
The most common symptoms of cancer are unintended weight loss, loss of appetite, fatigue or tiredness, and gastrointestinal discomforts and symptoms depending on the location of the cancer.
If you experience some of the above symptoms, please check with your doctor to rule out the p[ossibility of the disease.
The causes of cancer are unknown. Researchers can not explain why people with the same health conditions, and family history in the same family, are susceptible to cancer, while others do not.
In normal cells, overproduction of free radicals or oxidative stress can affect the cell lipid, protein, leading to cell damage or alteration of cell DNA.
Most cases of natural remedies initiating the cytotoxic effects against cancer without causing nearby healthy cell death probably are associated with the stimulation of the production of antioxidants produced by the host and the presence of antioxidants in the remedy.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
Researchers on finding a natural compound with cytotoxic potency examined the bilberry chemical compound in facilitating the onset of cytotoxicity against cancer and neutralizing the neuro cytotoxicity against the formation of plague on K562 Human Erythroleukemic cancer cells and Alzheimer's diseases (AD), respectively.
GroES self-assembled into amyloid fibrils similar to those observed in various neurodegenerative diseases was found to induce cell toxicity.
Before the application of bilberry anthocyanins, injection of soluble intermediate aggregates of GroES exhibited neuronal cell death, rather than forming mature fibrils.
Pretreatment with anthocyanins isolated from bilberry, not only inhibited both fibril formation but also neutralized the toxicity of intermediates.
The findings strongly suggested anthocyanins processes an inhibitory effect on the amyloid fibril formation of various conformational disease-causing proteins.
Oppositely, in cancer perspective, anthocyanins stimulated the tumor suppressor genes to induce apoptosis in cancer cells.
Dr. Seth P. Thibado and colleagues in the study to enhance the chemical compound bioavailability, observed the cytotoxicity of anthocyanins in an encapsulated in 5.5 nm diameter liposomal micelles, called NutraNanoSpheres (NNS), at a concentration of 2.5 mg/50 µl [25% (w/w) anthocyanins].
Bilberry NNS induced the apoptotic/cytotoxic effects on K562 Human Erythroleukemic cancer cells.
The concentrations of bilberry demonstrated the greatest levels of percentage inhibition of 60–70% at 0.018–1.14 mg/ml (n=6) and 60% inhibition at 4 mg/ml, compared to control.
And, the lowest percentage of inhibition (30%) occurred at 2 mg/ml. The lethal dose 50 was determined to be 0.01–0.04 mg/ml of Bilberry per 105 K562 cells at 72 h of cell culture exposure.
At 48 h incubation, the highest percentage of inhibition was only 27%,.
The findings clearly suggested that NutraNanoSpheres (NNS) demonstrates direct cytotoxic effects, at a concentration which is 8–40 times lower than the levels required for bilberry if not encapsulated.
Taken altogether, bilberry processed abundantly bioactive ingredient anthocyanins may be considered a functional remedy in modulation the cytotoxic activity against cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bilberry anthocyanins neutralize the cytotoxicity of co-chaperonin GroES fibrillation intermediates by Iwasa H1, Kameda H, Fukui N, Yoshida S, Hongo K, Mizobata T, Kobayashi S, Kawata Y. (PubMed)
(2) Anticancer effects of Bilberry anthocyanins compared with NutraNanoSphere encapsulated Bilberry anthocyanins by Seth P. Thibado,1 Jerry T. Thornthwaite,2 Thomas K. Ballard,2 and Brandon T. Goodman. (PMC)
Cytotoxicity is a process or action that destroys the living cells, through activating the production of pro-inflammatory cytokines and proteins associated with cell apoptosis and programmed cell death.
Free radical cytotoxicity is the ability of ROS in exerting oxidative stress in the cancer cells, leading to apoptosis.
Cancer is a class of diseases characterized by irregular cell growth due to DNA alternation.
Most cancers do not cause any symptoms at an early stage. However, at the later stage, a larger size of the tumor can press on the nearby blood vessels and nerve cells, causing localized bleeding and severe pain.
The most common symptoms of cancer are unintended weight loss, loss of appetite, fatigue or tiredness, and gastrointestinal discomforts and symptoms depending on the location of the cancer.
If you experience some of the above symptoms, please check with your doctor to rule out the p[ossibility of the disease.
The causes of cancer are unknown. Researchers can not explain why people with the same health conditions, and family history in the same family, are susceptible to cancer, while others do not.
In normal cells, overproduction of free radicals or oxidative stress can affect the cell lipid, protein, leading to cell damage or alteration of cell DNA.
Most cases of natural remedies initiating the cytotoxic effects against cancer without causing nearby healthy cell death probably are associated with the stimulation of the production of antioxidants produced by the host and the presence of antioxidants in the remedy.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
Researchers on finding a natural compound with cytotoxic potency examined the bilberry chemical compound in facilitating the onset of cytotoxicity against cancer and neutralizing the neuro cytotoxicity against the formation of plague on K562 Human Erythroleukemic cancer cells and Alzheimer's diseases (AD), respectively.
GroES self-assembled into amyloid fibrils similar to those observed in various neurodegenerative diseases was found to induce cell toxicity.
Before the application of bilberry anthocyanins, injection of soluble intermediate aggregates of GroES exhibited neuronal cell death, rather than forming mature fibrils.
Pretreatment with anthocyanins isolated from bilberry, not only inhibited both fibril formation but also neutralized the toxicity of intermediates.
The findings strongly suggested anthocyanins processes an inhibitory effect on the amyloid fibril formation of various conformational disease-causing proteins.
Oppositely, in cancer perspective, anthocyanins stimulated the tumor suppressor genes to induce apoptosis in cancer cells.
Dr. Seth P. Thibado and colleagues in the study to enhance the chemical compound bioavailability, observed the cytotoxicity of anthocyanins in an encapsulated in 5.5 nm diameter liposomal micelles, called NutraNanoSpheres (NNS), at a concentration of 2.5 mg/50 µl [25% (w/w) anthocyanins].
Bilberry NNS induced the apoptotic/cytotoxic effects on K562 Human Erythroleukemic cancer cells.
The concentrations of bilberry demonstrated the greatest levels of percentage inhibition of 60–70% at 0.018–1.14 mg/ml (n=6) and 60% inhibition at 4 mg/ml, compared to control.
And, the lowest percentage of inhibition (30%) occurred at 2 mg/ml. The lethal dose 50 was determined to be 0.01–0.04 mg/ml of Bilberry per 105 K562 cells at 72 h of cell culture exposure.
At 48 h incubation, the highest percentage of inhibition was only 27%,.
The findings clearly suggested that NutraNanoSpheres (NNS) demonstrates direct cytotoxic effects, at a concentration which is 8–40 times lower than the levels required for bilberry if not encapsulated.
Taken altogether, bilberry processed abundantly bioactive ingredient anthocyanins may be considered a functional remedy in modulation the cytotoxic activity against cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bilberry anthocyanins neutralize the cytotoxicity of co-chaperonin GroES fibrillation intermediates by Iwasa H1, Kameda H, Fukui N, Yoshida S, Hongo K, Mizobata T, Kobayashi S, Kawata Y. (PubMed)
(2) Anticancer effects of Bilberry anthocyanins compared with NutraNanoSphere encapsulated Bilberry anthocyanins by Seth P. Thibado,1 Jerry T. Thornthwaite,2 Thomas K. Ballard,2 and Brandon T. Goodman. (PMC)
#Ginger Shows a Reduction of Pain and Disability in Patients with #Osteoarthritis
Kyle J. Norton
Ginger may have a potential and positive effect in ameliorating the symptoms of pain and complication of reduced quality of life in patients with osteoarthritis, some scientists suggested.
Osteoarthritis (OA) is a chronic condition a type of joint disease characterized by the breaking down of joint cartilage and underlying bone due to “wear and tear” of joints over time.
Some researchers suggested that OA is a degenerative disease characterized by “low-grade inflammation” in cartilage and synovium, affecting the joint structure and progressive deterioration of cartilage.
According to the statistic from the NIH, osteoarthritis (OA) is the most common joint disorder in the US. Among adults, 60 years of age or older the prevalence of symptomatic knee and sadly OA affects approximately 10% of men and 13% of women.
Epidemiological strongly suggested that obese and overweight have a strong impact on weight-bearing joints, the genetic preposition of a patient can make such a patient more susceptible to the disease compared to others who do not, and people with a joint injury that did heal properly in the younger age and people with occupations that require standing for long periods of time, repetitive bending, heavy lifting or other movements and the increase in age are associated to the increased risk of the onset of the disease.
The most common symptoms of osteoarthritis are joint pain and stiffness.
Dr. Giuseppe Musumeci, the lead author in the study "Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression" suggested that besides the risk factors mentioned above, dietary factors also play an important role in the onset of the disease.
In the dietary aspect of the induction of OA, the research team wrote, "This diet (The Western diet) is mainly constituted by preservative and harmful substances, such as animal fat and glucose excessive concentration and lack of nutritional factors, such as vitamins and nutrient minerals essential for our body. Moreover, bad dietary habits may predispose people to obesity, which is responsible for both metabolic destroying processes affecting the cartilage and overload of the joints, especially hips and knees".
And, " quantity and quality of nutrient intake. Low intake of vitamin D and vitamin C is a possible risk factor for knee OA, while certain food groups, such as milk and dairy products, meat and poultry are beneficial for knee OA. Thus we could affirm that nutritional imbalance, combined with endocrine abnormalities, may be involved in the pathogenesis of OA".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to reaffirm the traditional use of ginger for the treatment of osteoarthritis, a joint review led by the Copenhagen University Hospital, Bispebjerg, and Frederiksberg was conducted to assess the clinical efficacy and safety of oral ginger for the symptomatic treatment of osteoarthritis (OA).
The study was carried out by searching the randomized controlled trials (RCTs) comparing oral ginger treatment with a placebo in OA patients aged >18 years who satisfied the predetermined guidelines and criteria, including the outcomes of the reduction in pain and disability.
Out of 122 retrieved references, 117 were discarded, and only 5 five trials (593 patients) were selected for meta-analyses.
All 5 remaining studies suggested that ginger intake scored a statistically significant pain reduction.
Furthermore, the application of ginger in subjects with osteoarthritis demonstrates a statistically significant reduction in disability compared to control.
However, according to the returned questionnaires from the participants, researchers surprisingly found that patients given ginger are more than twice as likely to discontinue treatment compared to placebo.
Dr. Mozaffari-Khosravi H, the lead author, launched a joint study to determine ginger powder effects in relieving pain and inflammation in patients with osteoarthritis.
120 participants selected for the randomized double-blind placebo-controlled 3-month clinical trial for knee osteoarthritis were randomly assigned to one of two groups: the ginger group (GG) or the placebo group (PG).
Ginger selected group was given capsules containing 500 mg of ginger powder, while the PG group was given capsules filled with 500 mg of starch.
At the baseline, proinflammatory cytokine concentrations did not differ by group, observed by the participant's blood sample.
After 3 months, GG showed a significant reduction of cytokines compared to PG.
In the final report, the research team wrote, "Ginger supplementation may have promising benefits for knee osteoarthritis".
These results reconfirm the use of ginger for the treatment of osteoarthritis in traditional medicine with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To ProfessionalsPrediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials by Bartels EM1, Folmer VN2, Bliddal H2, Altman RD3, Juhl C4, Tarp S2, Zhang W5, Christensen R. (PubMed)
(2) Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial by Mozaffari-Khosravi H1,2, Naderi Z1, Dehghan A3, Nadjarzadeh A1, Fallah Huseini H. (PubMed)
(3) Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression by Giuseppe Musumeci,1,* Flavia Concetta Aiello,1 Marta Anna Szychlinska,1Michelino Di Rosa,2 Paola Castrogiovanni,1 and Ali Mobasheri. (PubMed)
Ginger may have a potential and positive effect in ameliorating the symptoms of pain and complication of reduced quality of life in patients with osteoarthritis, some scientists suggested.
Osteoarthritis (OA) is a chronic condition a type of joint disease characterized by the breaking down of joint cartilage and underlying bone due to “wear and tear” of joints over time.
Some researchers suggested that OA is a degenerative disease characterized by “low-grade inflammation” in cartilage and synovium, affecting the joint structure and progressive deterioration of cartilage.
According to the statistic from the NIH, osteoarthritis (OA) is the most common joint disorder in the US. Among adults, 60 years of age or older the prevalence of symptomatic knee and sadly OA affects approximately 10% of men and 13% of women.
Epidemiological strongly suggested that obese and overweight have a strong impact on weight-bearing joints, the genetic preposition of a patient can make such a patient more susceptible to the disease compared to others who do not, and people with a joint injury that did heal properly in the younger age and people with occupations that require standing for long periods of time, repetitive bending, heavy lifting or other movements and the increase in age are associated to the increased risk of the onset of the disease.
The most common symptoms of osteoarthritis are joint pain and stiffness.
Dr. Giuseppe Musumeci, the lead author in the study "Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression" suggested that besides the risk factors mentioned above, dietary factors also play an important role in the onset of the disease.
In the dietary aspect of the induction of OA, the research team wrote, "This diet (The Western diet) is mainly constituted by preservative and harmful substances, such as animal fat and glucose excessive concentration and lack of nutritional factors, such as vitamins and nutrient minerals essential for our body. Moreover, bad dietary habits may predispose people to obesity, which is responsible for both metabolic destroying processes affecting the cartilage and overload of the joints, especially hips and knees".
And, " quantity and quality of nutrient intake. Low intake of vitamin D and vitamin C is a possible risk factor for knee OA, while certain food groups, such as milk and dairy products, meat and poultry are beneficial for knee OA. Thus we could affirm that nutritional imbalance, combined with endocrine abnormalities, may be involved in the pathogenesis of OA".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to reaffirm the traditional use of ginger for the treatment of osteoarthritis, a joint review led by the Copenhagen University Hospital, Bispebjerg, and Frederiksberg was conducted to assess the clinical efficacy and safety of oral ginger for the symptomatic treatment of osteoarthritis (OA).
The study was carried out by searching the randomized controlled trials (RCTs) comparing oral ginger treatment with a placebo in OA patients aged >18 years who satisfied the predetermined guidelines and criteria, including the outcomes of the reduction in pain and disability.
Out of 122 retrieved references, 117 were discarded, and only 5 five trials (593 patients) were selected for meta-analyses.
All 5 remaining studies suggested that ginger intake scored a statistically significant pain reduction.
Furthermore, the application of ginger in subjects with osteoarthritis demonstrates a statistically significant reduction in disability compared to control.
However, according to the returned questionnaires from the participants, researchers surprisingly found that patients given ginger are more than twice as likely to discontinue treatment compared to placebo.
Dr. Mozaffari-Khosravi H, the lead author, launched a joint study to determine ginger powder effects in relieving pain and inflammation in patients with osteoarthritis.
120 participants selected for the randomized double-blind placebo-controlled 3-month clinical trial for knee osteoarthritis were randomly assigned to one of two groups: the ginger group (GG) or the placebo group (PG).
Ginger selected group was given capsules containing 500 mg of ginger powder, while the PG group was given capsules filled with 500 mg of starch.
At the baseline, proinflammatory cytokine concentrations did not differ by group, observed by the participant's blood sample.
After 3 months, GG showed a significant reduction of cytokines compared to PG.
In the final report, the research team wrote, "Ginger supplementation may have promising benefits for knee osteoarthritis".
These results reconfirm the use of ginger for the treatment of osteoarthritis in traditional medicine with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To ProfessionalsPrediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials by Bartels EM1, Folmer VN2, Bliddal H2, Altman RD3, Juhl C4, Tarp S2, Zhang W5, Christensen R. (PubMed)
(2) Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial by Mozaffari-Khosravi H1,2, Naderi Z1, Dehghan A3, Nadjarzadeh A1, Fallah Huseini H. (PubMed)
(3) Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression by Giuseppe Musumeci,1,* Flavia Concetta Aiello,1 Marta Anna Szychlinska,1Michelino Di Rosa,2 Paola Castrogiovanni,1 and Ali Mobasheri. (PubMed)
#BlackBean Inhibits Liver Toxicity Associated with the Onset of #ChronicLiverDisease, Researchers Show
Kyle J. Norton
Compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending on the stage of the treatment which directly addresses the cause of the disease.
Intake of black beans regularly may have a profound effect in reducing the risk and treatment of liver cancer, a renowned institute study proposed.
Liver cancer is a condition of the abnormal growth of the cells in the liver's tissue.
According to statistics approximately 40,710 adults (29,200 men and 11,510 women) in the United States will be diagnosed with primary liver cancer this year.
The exact causes of liver cancer. However, researchers believed that age, gender, excessive use of alcohol, obesity, are ethnicity are associated with the increased risk of liver cancer.
Furthermore, gene mutation such as inherited metabolic diseases is also considered as the major prevalent risk factor of liver cancer onset.
More importantly, certain chronic diseases, such as diabetes, infection by hepatitis virus, liver diseases, including cirrhosis, and non-alcoholic fatty liver disease chemical toxins and long-term use of certain medications such as acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs) aspirin, also have the potential to increased risk of liver cancer.
Besides sharing the general symptoms of cancers, patients with liver cancer also experience symptoms of upper abdominal pain and swelling, yellow discoloration of the skin, jaundice,.... and chalky stool.
If you have some of the above symptoms, please check with your doctor to rule out the possibility.
Black bean, small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae.
The legume can be bought in most grocery stores all around the year in dried and canned forms.
It is believed that black bean was the first domesticated growth in South America.
According to Stocking Hall, Cornell University, phytochemicals isolated from black beans such as triterpenoids, flavonoids, and other compounds exhibited antiproliferative activities against the HepG2 cells, the human liver cancer cell line.
The efficacy of black beans on the ameliorated growth of liver cancer may be attributed to the presence of some potent antioxidants in the expression of apoptosis.
Additionally, the consumption of beans not only played a prominent role in gene expression involving the regulation of gene Hspa8 on reduced risk of liver disease but also addressed the important issue of attenuating hepatic stress or toxicity in the rat model.
In fact, increased bean consumption in rats exhibits changes in the hepatic damage caused by liver toxicity. Dr. Daniell EL, the lead author said, "Dry bean (Phaseolus vulgaris L.) consumption is associated with reduced risk for a number of chronic diseases", such as liver cancer.
More interestingly, dietary bean concentrations.is found to associate with the cholesterol 7α hydroxylase and UDP-glucuronosyltransferase genes increased with a connection to the development of liver cancer, in a dose-dependent manner.
These findings suggested that dietary black(dried) beans may have a potential effect in reducing the risk and treatment of liver cancer through antioxidant activity and regulated genes involved early onset of the disease.
However, further data collection on large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of black bean anti-liver cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phytochemicals of black bean seed coats: isolation, structure elucidation, and their antiproliferative and antioxidative activities by Dong M1, He X, Liu RH. (PubMed)
(2) Dietary dry bean effects on hepatic expression of stress and toxicity-related genes in rats by Daniell EL1, Ryan EP, Brick MA, Thompson HJ. (PubMed)
Compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending on the stage of the treatment which directly addresses the cause of the disease.
Intake of black beans regularly may have a profound effect in reducing the risk and treatment of liver cancer, a renowned institute study proposed.
Liver cancer is a condition of the abnormal growth of the cells in the liver's tissue.
According to statistics approximately 40,710 adults (29,200 men and 11,510 women) in the United States will be diagnosed with primary liver cancer this year.
The exact causes of liver cancer. However, researchers believed that age, gender, excessive use of alcohol, obesity, are ethnicity are associated with the increased risk of liver cancer.
Furthermore, gene mutation such as inherited metabolic diseases is also considered as the major prevalent risk factor of liver cancer onset.
More importantly, certain chronic diseases, such as diabetes, infection by hepatitis virus, liver diseases, including cirrhosis, and non-alcoholic fatty liver disease chemical toxins and long-term use of certain medications such as acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs) aspirin, also have the potential to increased risk of liver cancer.
Besides sharing the general symptoms of cancers, patients with liver cancer also experience symptoms of upper abdominal pain and swelling, yellow discoloration of the skin, jaundice,.... and chalky stool.
If you have some of the above symptoms, please check with your doctor to rule out the possibility.
Black bean, small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae.
The legume can be bought in most grocery stores all around the year in dried and canned forms.
It is believed that black bean was the first domesticated growth in South America.
According to Stocking Hall, Cornell University, phytochemicals isolated from black beans such as triterpenoids, flavonoids, and other compounds exhibited antiproliferative activities against the HepG2 cells, the human liver cancer cell line.
The efficacy of black beans on the ameliorated growth of liver cancer may be attributed to the presence of some potent antioxidants in the expression of apoptosis.
Additionally, the consumption of beans not only played a prominent role in gene expression involving the regulation of gene Hspa8 on reduced risk of liver disease but also addressed the important issue of attenuating hepatic stress or toxicity in the rat model.
In fact, increased bean consumption in rats exhibits changes in the hepatic damage caused by liver toxicity. Dr. Daniell EL, the lead author said, "Dry bean (Phaseolus vulgaris L.) consumption is associated with reduced risk for a number of chronic diseases", such as liver cancer.
More interestingly, dietary bean concentrations.is found to associate with the cholesterol 7α hydroxylase and UDP-glucuronosyltransferase genes increased with a connection to the development of liver cancer, in a dose-dependent manner.
These findings suggested that dietary black(dried) beans may have a potential effect in reducing the risk and treatment of liver cancer through antioxidant activity and regulated genes involved early onset of the disease.
However, further data collection on large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of black bean anti-liver cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phytochemicals of black bean seed coats: isolation, structure elucidation, and their antiproliferative and antioxidative activities by Dong M1, He X, Liu RH. (PubMed)
(2) Dietary dry bean effects on hepatic expression of stress and toxicity-related genes in rats by Daniell EL1, Ryan EP, Brick MA, Thompson HJ. (PubMed)
#Beet or #Beetroot Reduces the Risk of Inflammatory Bowel Disease Through Its Antioxidant Activity
Kyle J. Norton
Beet or Beetroot may have a potential effect in ameliorating the abnormal function of white blood cells such as neutrophils in reduced risk and treatment of inflammatory bowel disease.
Inflammation is a natural process of immune defense to remove injurious agents, cells, and tissues from the body.
Inflammatory bowel disease is the border term of conditions characterized by chronic inflammation of the intestines, including ulcerative colitis and Crohn's disease.
Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.
According to the Poznan University of Medical Science, beetroot (Beta vulgaris var. rubra) products and their major component, betanin exhibited antioxidant activities against abnormal neutrophils in modulated reactive oxygen species (ROS) production and DNA damage, in healthy subjects.
The efficacy of betanin in reduced reactive oxygen species (ROS) expression is the result of exerting antioxidant free radical scavenging and neutralizing activities by slowing down or preventing the initiation of free radical chain reactions.
Additionally, betanin, as a major phytochemical also ameliorated the elevated ROS expression in promoted oxidative stress which was found to have a strong implication to cause cellular DNA damage. Some researchers suggested that betanin reduced the risk of cellular DNA damage. probably through inter-influenced the pro-apoptotic caspase-3 in the action of the release of ROS and apoptotic cell death.
Indeed, activities of betanin in the attenuated risk of overexpression of ROS in the induction of DNA also may be an extrinsic way for the phytochemical in exerting anti-inflammatory and potentially cancer-preventive activity.
Further analysis and taking into account other confounders, researchers once again indicated that betanin with a concentration of 100 μM for 24 h, inhibited pro-inflammatory expression in ulcerative colitis (UC) and Crohn's disease (CD) patients by protecting the digestive tract that can be observed through action in decreased oxidative DNA damage and promoted apoptosis in neutrophils.
In fact, betaine and other phytochemical baicalein have been shown to provide various health benefits to an organism in many ways, including down-regulation of inflammation against colitis-associated colon tumorigenesis in the tested animals.
In the case of anti-inflammation, both betaine and baicalein were also found to demonstrate a magnificent impact in the regulation of the pro-inflammatory cytokines such as IL-1β, PGE2, and TNF-α in NF-ĸB activation besides activities in the inhibited expression of ROS.
Interestingly, in patients with ulcerative colitis, arabino-oligosaccharides (AOS) derived from sugar beet pulp, stimulated Bifidobacterium spp. and Lactobacillus spp. accompanied by a high production of acetate in eliciting anti-inflammatory responses, thus attenuating inflammatory conditions in UC patients.
The observation illustrated that beet may have the potential in acting as prebiotic to enhance the growth of beneficial microorganisms in the intestines, thus reducing the risk of flare-ups in UC patients.
Furthermore, arabinose-oligosaccharides (AOS) also showed to elevate the failure of local anesthesia in inflamed tissues through lowering of intestinal pH
The findings of improved antioxidants in attenuated free radicals in the induction of DNA and promotion of abnormal expression of neutrophils, as well as acting as a prebiotic suggested that beet may be considered as a functional food in reduced risk of chronically digestive inflammatory diseases, particularly in inflammatory bowel disease.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel diseasepatients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W1.(PubMed)
(2) Modulation of Colitis-associated Colon Tumorigenesis by Baicalein and Betaine by Kim DH1, Sung B1, Chung HY1, Kim ND1.(PubMed)
(3) In vitro fermentation of sugar beet arabino-oligosaccharides by fecal microbiota obtained from patients with ulcerative colitis to selectively stimulate the growth of Bifidobacterium spp. and Lactobacillus spp by Vigsnæs LK1, Holck J, Meyer AS, Licht TR.(PubMed)
(4) Anti-inflammatory activity of baicalein in LPS-stimulated RAW264.7 macrophages via estrogen receptor and NF-κB-dependent pathways by Fan GW1, Zhang Y, Jiang X, Zhu Y, Wang B, Su L, Cao W, Zhang H, Gao X.(PubMed)
Beet or Beetroot may have a potential effect in ameliorating the abnormal function of white blood cells such as neutrophils in reduced risk and treatment of inflammatory bowel disease.
Inflammation is a natural process of immune defense to remove injurious agents, cells, and tissues from the body.
Inflammatory bowel disease is the border term of conditions characterized by chronic inflammation of the intestines, including ulcerative colitis and Crohn's disease.
Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.
According to the Poznan University of Medical Science, beetroot (Beta vulgaris var. rubra) products and their major component, betanin exhibited antioxidant activities against abnormal neutrophils in modulated reactive oxygen species (ROS) production and DNA damage, in healthy subjects.
The efficacy of betanin in reduced reactive oxygen species (ROS) expression is the result of exerting antioxidant free radical scavenging and neutralizing activities by slowing down or preventing the initiation of free radical chain reactions.
Additionally, betanin, as a major phytochemical also ameliorated the elevated ROS expression in promoted oxidative stress which was found to have a strong implication to cause cellular DNA damage. Some researchers suggested that betanin reduced the risk of cellular DNA damage. probably through inter-influenced the pro-apoptotic caspase-3 in the action of the release of ROS and apoptotic cell death.
Indeed, activities of betanin in the attenuated risk of overexpression of ROS in the induction of DNA also may be an extrinsic way for the phytochemical in exerting anti-inflammatory and potentially cancer-preventive activity.
Further analysis and taking into account other confounders, researchers once again indicated that betanin with a concentration of 100 μM for 24 h, inhibited pro-inflammatory expression in ulcerative colitis (UC) and Crohn's disease (CD) patients by protecting the digestive tract that can be observed through action in decreased oxidative DNA damage and promoted apoptosis in neutrophils.
In fact, betaine and other phytochemical baicalein have been shown to provide various health benefits to an organism in many ways, including down-regulation of inflammation against colitis-associated colon tumorigenesis in the tested animals.
In the case of anti-inflammation, both betaine and baicalein were also found to demonstrate a magnificent impact in the regulation of the pro-inflammatory cytokines such as IL-1β, PGE2, and TNF-α in NF-ĸB activation besides activities in the inhibited expression of ROS.
Interestingly, in patients with ulcerative colitis, arabino-oligosaccharides (AOS) derived from sugar beet pulp, stimulated Bifidobacterium spp. and Lactobacillus spp. accompanied by a high production of acetate in eliciting anti-inflammatory responses, thus attenuating inflammatory conditions in UC patients.
The observation illustrated that beet may have the potential in acting as prebiotic to enhance the growth of beneficial microorganisms in the intestines, thus reducing the risk of flare-ups in UC patients.
Furthermore, arabinose-oligosaccharides (AOS) also showed to elevate the failure of local anesthesia in inflamed tissues through lowering of intestinal pH
The findings of improved antioxidants in attenuated free radicals in the induction of DNA and promotion of abnormal expression of neutrophils, as well as acting as a prebiotic suggested that beet may be considered as a functional food in reduced risk of chronically digestive inflammatory diseases, particularly in inflammatory bowel disease.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel diseasepatients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W1.(PubMed)
(2) Modulation of Colitis-associated Colon Tumorigenesis by Baicalein and Betaine by Kim DH1, Sung B1, Chung HY1, Kim ND1.(PubMed)
(3) In vitro fermentation of sugar beet arabino-oligosaccharides by fecal microbiota obtained from patients with ulcerative colitis to selectively stimulate the growth of Bifidobacterium spp. and Lactobacillus spp by Vigsnæs LK1, Holck J, Meyer AS, Licht TR.(PubMed)
(4) Anti-inflammatory activity of baicalein in LPS-stimulated RAW264.7 macrophages via estrogen receptor and NF-κB-dependent pathways by Fan GW1, Zhang Y, Jiang X, Zhu Y, Wang B, Su L, Cao W, Zhang H, Gao X.(PubMed)
#CucumberSeeds Inhibit Bacterial Infection and Improve Bood Bacteria in the Gut, According to Studies
Kyle J. Norton
Infection is a condition that leads to inflammation caused by the invasion of a microbial organism on body tissues
The bacterial infection is the infection caused by bacteria. Most cases of bacterial infection are treated with antibiotics. However, bacteria are very adaptable, overuse of antibiotics has made many of them resistant to antibiotics.
There are trillions of strains of bacteria in the world, but only a few of these cause diseases in humans. Some of them live inside our gut.
The most common symptoms of bacterial infection include redness and heat, swelling, fever, and pain at the site of infection.
In severe cases, the patient may also experience symptoms of swollen lymph glands.
Most cases of bacterial infection can be treated successfully if the types of bacteria that cause the infection are identified.
There are many risk factors associated with the onset of bacterial infection, some researchers suggested that people with a weakened immune system may increase the prevalence of bacterial infection.
Dr. Doyon PR, the lead scientist wrote, "Patients with a weakened immune system due to immunosuppressive treatment are at increased risk of infection with Streptococcus pneumonia".
And, " in patients treated with immunosuppressive medication and compared to controls, the initial serologic response to the pneumococcal conjugate vaccine (PCV) and pneumococcal polysaccharide vaccine (PPSV) is impaired. Moreover, this impaired response was more profound after PCV than after PPSV".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural antibiotic for the treatment of bacterial infection, researchers compared the effect of potassium phosphite (KPhi) and chitosan on Cucurbitacin E (CuE) concentration in different tissues of Cucumis sativus against E.coli PTCC 1399 and Pseudomonas aeruginosa PTCC 1430 bacterial strains.
The experiment includes
* Group1. Leaves were sprayed with distilled water (Control),
* Group 2. The leaves were solely treated with potassium phosphate (KPhi),
* Group 3. Leaves were solely sprayed with chitosan (Chitosan), and
* Group 4. Leaves were treated with KPhi and chitosan (KPhi + chitosan).
Where the KPhi (2 g L-1) and chitosan (0.2 g L-1) were applied twice every 12 h for one day. Fruits, roots, and leaves were harvested 24 h later.
According to the results of antibacterial activity in each group, the highest level of CuE was found in fruit (2.2 g L-1) of plants under concomitant applications of KPhi and chitosan.
In other words, under the infected stage, fruit extract exhibited the highest potential for activity against E. coli PTCC 1399 (with a mean zone of inhibition equal to 36 mm) and Pseudomonas aeruginosa PTCC 1430 (with a mean zone of inhibition equal to 33 mm).
Based on the findings, researchers concluded, "KPhi and chitosan can induce production of CuE compound and increase the antibacterial potential of cucumber plant extract".
Additionally, researchers in the examination of cucumber seed's antibacterial effect also found that besides acting as natural antibiotics without affecting nearby healthy cells, cucumber seed also has strong activity in improving good bacteria in the gut.
Precisely, cucumber seed enhanced the total number of gut bacteria and altered the abundance of specific bacterial phylum or genera.
Taken altogether, cucumber and its bioactive compound cucurbitacin B (CuB) may be used for the treatment of bacterial infection, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Comparison between the effects of potassium phosphite and chitosan on changes in the concentration of Cucurbitacin E and on the antibacterial property of Cucumis sativus by Ramezani M1, Rahmani F2, Dehestani A. (PubMed)
(2) Chemical Compositions of Cold-Pressed Broccoli, Carrot, and Cucumber Seed Flours and They're in Vitro Gut Microbiota Modulatory, Anti-inflammatory, and Free Radical Scavenging Properties by Choe U1, Li Y1,2, Gao B2, Yu L1, Wang TTY, Sun J, Chen P, Liu J3, Yu L. (PubMed)
(3) The effect of immunosuppressive agents on the immunogenicity of pneumococcal vaccination: A systematic review and meta-analysis by van Aalst M1, Langedijk AC1, Spijker R2, de Bree GJ Grobusch MP4, Goorhuis A. (PMC)
Infection is a condition that leads to inflammation caused by the invasion of a microbial organism on body tissues
The bacterial infection is the infection caused by bacteria. Most cases of bacterial infection are treated with antibiotics. However, bacteria are very adaptable, overuse of antibiotics has made many of them resistant to antibiotics.
There are trillions of strains of bacteria in the world, but only a few of these cause diseases in humans. Some of them live inside our gut.
The most common symptoms of bacterial infection include redness and heat, swelling, fever, and pain at the site of infection.
In severe cases, the patient may also experience symptoms of swollen lymph glands.
Most cases of bacterial infection can be treated successfully if the types of bacteria that cause the infection are identified.
There are many risk factors associated with the onset of bacterial infection, some researchers suggested that people with a weakened immune system may increase the prevalence of bacterial infection.
Dr. Doyon PR, the lead scientist wrote, "Patients with a weakened immune system due to immunosuppressive treatment are at increased risk of infection with Streptococcus pneumonia".
And, " in patients treated with immunosuppressive medication and compared to controls, the initial serologic response to the pneumococcal conjugate vaccine (PCV) and pneumococcal polysaccharide vaccine (PPSV) is impaired. Moreover, this impaired response was more profound after PCV than after PPSV".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural antibiotic for the treatment of bacterial infection, researchers compared the effect of potassium phosphite (KPhi) and chitosan on Cucurbitacin E (CuE) concentration in different tissues of Cucumis sativus against E.coli PTCC 1399 and Pseudomonas aeruginosa PTCC 1430 bacterial strains.
The experiment includes
* Group1. Leaves were sprayed with distilled water (Control),
* Group 2. The leaves were solely treated with potassium phosphate (KPhi),
* Group 3. Leaves were solely sprayed with chitosan (Chitosan), and
* Group 4. Leaves were treated with KPhi and chitosan (KPhi + chitosan).
Where the KPhi (2 g L-1) and chitosan (0.2 g L-1) were applied twice every 12 h for one day. Fruits, roots, and leaves were harvested 24 h later.
According to the results of antibacterial activity in each group, the highest level of CuE was found in fruit (2.2 g L-1) of plants under concomitant applications of KPhi and chitosan.
In other words, under the infected stage, fruit extract exhibited the highest potential for activity against E. coli PTCC 1399 (with a mean zone of inhibition equal to 36 mm) and Pseudomonas aeruginosa PTCC 1430 (with a mean zone of inhibition equal to 33 mm).
Based on the findings, researchers concluded, "KPhi and chitosan can induce production of CuE compound and increase the antibacterial potential of cucumber plant extract".
Additionally, researchers in the examination of cucumber seed's antibacterial effect also found that besides acting as natural antibiotics without affecting nearby healthy cells, cucumber seed also has strong activity in improving good bacteria in the gut.
Precisely, cucumber seed enhanced the total number of gut bacteria and altered the abundance of specific bacterial phylum or genera.
Taken altogether, cucumber and its bioactive compound cucurbitacin B (CuB) may be used for the treatment of bacterial infection, pending the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Comparison between the effects of potassium phosphite and chitosan on changes in the concentration of Cucurbitacin E and on the antibacterial property of Cucumis sativus by Ramezani M1, Rahmani F2, Dehestani A. (PubMed)
(2) Chemical Compositions of Cold-Pressed Broccoli, Carrot, and Cucumber Seed Flours and They're in Vitro Gut Microbiota Modulatory, Anti-inflammatory, and Free Radical Scavenging Properties by Choe U1, Li Y1,2, Gao B2, Yu L1, Wang TTY, Sun J, Chen P, Liu J3, Yu L. (PubMed)
(3) The effect of immunosuppressive agents on the immunogenicity of pneumococcal vaccination: A systematic review and meta-analysis by van Aalst M1, Langedijk AC1, Spijker R2, de Bree GJ Grobusch MP4, Goorhuis A. (PMC)
#GreenPeas Supplement Improves the Digestive Functioning, Researchers Say
Kyle J. Norton
An inflammatory bowel (IBD) disease is a group of chronic inflammatory diseases associated with the gastrointestinal tract, including ulcerative colitis and Crohn's disease.
Ulcerative colitis has been found to induce chronic inflammation and ulcers in the inner lining of the large intestine (colon) and rectum, causing diarrhea, often with blood or pus, abdominal pain, cramping, rectal pain, and bleeding, and urgency to defecate.
Crohn's disease is a type of IBD associated with the inflammation of the lining of the digestive tract, leading to symptoms of frequent, recurring diarrhea, rectal bleeding, unexplained weight loss, and fever.
and abdominal pain and cramping.
According to the statistics, provided by the CDC in the US, IBD affects over 1.3% or 3 million US adults including Crohn's disease or ulcerative colitis in 2015.
The most common symptoms of IBD include diarrhea, fever, fatigue, abdominal pain, and cramping, loss of appetite and unintended weight loss, and blood in the stool.
Conventionally, most cases of IBD are treated with anti-inflammatory medicine, immune suppressor or antibiotics, and drugs that reduce symptoms, depending on the severity of the conditions.
Most cases of IBD have been found in older adults in the age of 45 years or older.
Dr. Danielle Nimmons and Jimmy K Limdi said, "The incidence and prevalence of inflammatory bowel disease (IBD) are increasing globally. Coupled with an aging population, the number of older patients with IBD is set to increase. The clinical features and therapeutic options in young and elderly patients are comparable but there are some significant differences".
And, "In addition, age-specific concerns such as co-morbidity; loco-motor and cognitive function, poly-pharmacy and its consequences need to be taken into account. In applying modern treatment paradigms to the elderly, the clinician must consider the potential for more pronounced adverse effects in this vulnerable group and set appropriate boundaries maximizing benefit and minimizing harm".
Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalayas Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.
On finding a potent ingredient for the treatment of inflammatory bowel disease, researchers investigated the impact of green pea (GP) supplementation on the susceptibility of high-fat diet (HFD)-fed mice to dextran sulfate sodium (DSS)-induced colitis.
The study included 6-week-old C57BL/6J female mice fed a 45% HFD or HFD supplemented with 10% GP. for 7 weeks before colitis was induced by adding 2.5% DSS in drinking water for 7 days followed by a 7-day recovery period.
Based on the tested analysis, BP supplement showed a significant effect in ameliorating the disease index score in HFD-fed mice during the recovery stage by reducing neutrophil infiltration and chemokine associated with a pro-inflammatory response.
Furthermore, pro-inflammatory markers in the tested mice such as interleukin (IL)-6, cyclooxygenase-2 (COX-2), IL-17, interferon-γ (IFN-γ) were also inhibited by the administration of GP supplement.
Moreover, the mucin 2 content and goblet cell differentiation markers associated with the protection of digestive functioning were significantly increased by the GP supplement.
Additionally, the endoplasmic reticulum (ER) stress induced by the 2.5% DSS that causes digestive cell dysfunction was inhibited by the GP application.
Based on the findings, researchers wrote, "GP supplementation ameliorated the severity of DSS-induced colitis in HFD-fed mice, which was associated with the suppression of inflammation, mucin depletion, and ER stress in the colon".
Taken altogether, green peas may be considered a functional food for the prevention of inflammatory bowel disease, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet by Bibi S1, de Sousa Moraes LF2, Lebow N3, Zhu MJ. (PubMed)
An inflammatory bowel (IBD) disease is a group of chronic inflammatory diseases associated with the gastrointestinal tract, including ulcerative colitis and Crohn's disease.
Ulcerative colitis has been found to induce chronic inflammation and ulcers in the inner lining of the large intestine (colon) and rectum, causing diarrhea, often with blood or pus, abdominal pain, cramping, rectal pain, and bleeding, and urgency to defecate.
Crohn's disease is a type of IBD associated with the inflammation of the lining of the digestive tract, leading to symptoms of frequent, recurring diarrhea, rectal bleeding, unexplained weight loss, and fever.
and abdominal pain and cramping.
According to the statistics, provided by the CDC in the US, IBD affects over 1.3% or 3 million US adults including Crohn's disease or ulcerative colitis in 2015.
The most common symptoms of IBD include diarrhea, fever, fatigue, abdominal pain, and cramping, loss of appetite and unintended weight loss, and blood in the stool.
Conventionally, most cases of IBD are treated with anti-inflammatory medicine, immune suppressor or antibiotics, and drugs that reduce symptoms, depending on the severity of the conditions.
Most cases of IBD have been found in older adults in the age of 45 years or older.
Dr. Danielle Nimmons and Jimmy K Limdi said, "The incidence and prevalence of inflammatory bowel disease (IBD) are increasing globally. Coupled with an aging population, the number of older patients with IBD is set to increase. The clinical features and therapeutic options in young and elderly patients are comparable but there are some significant differences".
And, "In addition, age-specific concerns such as co-morbidity; loco-motor and cognitive function, poly-pharmacy and its consequences need to be taken into account. In applying modern treatment paradigms to the elderly, the clinician must consider the potential for more pronounced adverse effects in this vulnerable group and set appropriate boundaries maximizing benefit and minimizing harm".
Green peas are species of Pisum Sativum belongings to the family Fabaceae and native to western Asia from the Mediterranean Sea to the Himalayas Mountains. The pea is a green, pod-shaped vegetable and a cool-season crop grown in many parts of the world.
On finding a potent ingredient for the treatment of inflammatory bowel disease, researchers investigated the impact of green pea (GP) supplementation on the susceptibility of high-fat diet (HFD)-fed mice to dextran sulfate sodium (DSS)-induced colitis.
The study included 6-week-old C57BL/6J female mice fed a 45% HFD or HFD supplemented with 10% GP. for 7 weeks before colitis was induced by adding 2.5% DSS in drinking water for 7 days followed by a 7-day recovery period.
Based on the tested analysis, BP supplement showed a significant effect in ameliorating the disease index score in HFD-fed mice during the recovery stage by reducing neutrophil infiltration and chemokine associated with a pro-inflammatory response.
Furthermore, pro-inflammatory markers in the tested mice such as interleukin (IL)-6, cyclooxygenase-2 (COX-2), IL-17, interferon-γ (IFN-γ) were also inhibited by the administration of GP supplement.
Moreover, the mucin 2 content and goblet cell differentiation markers associated with the protection of digestive functioning were significantly increased by the GP supplement.
Additionally, the endoplasmic reticulum (ER) stress induced by the 2.5% DSS that causes digestive cell dysfunction was inhibited by the GP application.
Based on the findings, researchers wrote, "GP supplementation ameliorated the severity of DSS-induced colitis in HFD-fed mice, which was associated with the suppression of inflammation, mucin depletion, and ER stress in the colon".
Taken altogether, green peas may be considered a functional food for the prevention of inflammatory bowel disease, pending the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet by Bibi S1, de Sousa Moraes LF2, Lebow N3, Zhu MJ. (PubMed)
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