#CruciferousVegetables' #Sulforaphane Inhibit Oxidativestress Associated with a Risk of Diabetic Vascular Complications, Researchers Say

Kyle J. Norton

Diabetic vascular complications are caused by a diverse group of highly oxidant compounds(advanced glycation end(AGEs) produced by a modern heat-processed diet, inducing pathogenic significance in diabetes and several other chronic diseases.

Diabetes is a condition caused by insufficient insulin entering the bloodstream to regulate glucose. It is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Its complications may include renal failure and cardiovascular events.

Intake of Cruciferous Vegetables regularly may be beneficial in reducing the risk of diabetic vascular complications.

Cruciferous vegetables are a group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.

Dr, Yamagishi S, the lead author said, " the Inhibition of AGE formation, blockade of the AGE-RAGE interaction, and suppression of RAGE expression or its downstream pathways may be novel therapeutic strategies for the treatment of vascular complications in diabetes"

Some researchers insisted that diabetic vascular complications may be blocked if food-advanced glycation end-products aggravate diabetic vascular complications via modulating the RAGE receptors in the removal of AGE.

According to the Kurume University School of Medicine, sulforaphane, a phytochemical compound found in cruciferous vegetables showed a potential effect against diabetic vascular complications, through its interference with pro-inflammatory reactions, and reduction of oxidate stress.

In cultured cells and experimental animals, sulforaphane suppressed inflammatory activation of vascular cells, and induced potential beneficial effects to prevent vascular inflammation and atherosclerosis complication of diabetics.

Therefore, intake of Cruciferous Vegetables may reduce the risk of diabetic vascular complications as sulforaphane, a phytochemical compound in cruciferous vegetables not only inhibited the levels of advanced glycation end but also enhanced the production of Nrf2 in controlling over 500 genes expression of cellular defense mechanisms.


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Sources
(1) Protective role of sulforaphane against vascular complications in diabetes by Yamagishi S1, Matsui T1. (PubMed)
(2) Agents that block advanced glycation end product (AGE)-RAGE (receptor for AGEs)-oxidative stress system: a novel therapeutic strategy for diabetic vascular complications by Yamagishi S1, Nakamura K, Matsui T, Ueda S, Fukami K, Okuda S.(PubMed)
(3) The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease by Paul C. Evans(PMC)
(4) Food-advanced glycation end products aggravate diabetic vascular complications via modulating the AGEs/RAGE pathway by Lv X1, Lv GH1, Dai GY1, Sun HM2, and Xu HQ3. (PubMed)

#Herbal #Coltsfoot Protects the Small Intestinal Epithelium Against Adverse Effect on #Chemotherapy, Researchers Suggest

Kyle J. Norton

The digestive system including the gastrointestinal tract, the liver, pancreas, and gallbladder play a critical role to maintain the body's normal function by providing nutrients and fluids to the body and removing waste through the secretary system.
Digestion is a process of the digestive system by breaking out food after food intake through mechanical and enzymatic action.

The intestinal epithelium formed part of the intestinal mucosal barrier, is the single-cell layer formed the lining of both the small and large intestine(colon) of the gastrointestinal tract with functions to absorb useful substances into the body and block the entry of harmful pathogens.

Dr. Catalioto RM, the lead scientist in examing the intestinal epithelial barrier dysfunction wrote, "Epithelial cells are linked together at the apical junctional complex by tight junctions that reduce the extracellular space and the passage of charge entities while forming a physical barrier to lipophilic molecules".

And, "Cultured intestinal epithelial cells have been extensively used to study intestinal absorption of newly synthesized drugs and the regulation of tight junctions structure and function. In vitro mild irritants, proinflammatory cytokines, toxins and pathogens, and adverse environmental conditions open tight junctions and increase paracellular permeability, an effect often accompanied by immune activation of the enterocytes".

In other words, intestinal epithelium dysfunction induces the risk of various intestinal and non-intestinal disorders including inflammatory bowel disease, celiac disease, and diarrhoeal infection.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used for thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

In finding a potential compound for the improvement of digestive functioning, researchers examined the protective effect of Tussilagone (TSL) on mall intestinal epithelium against foreign pathogens.

According to the DNA comet assay, in C57Bl/6 mice, the chemical constituent of polysaccharides from Tussilago farfara L. reduced the intensity of polychemotherapy-induced apoptosis in the intestinal epithelial cells.

In other words, TSL not only enhanced the efficacy of the chemo drug but also inhibited the cytotoxicity of the adverse effect of chemo-induced death or DNA damage of intestinal epithelial cells through its geno-protective properties.

Taken altogether, coltsfoot may be considered a remedy for the protection of small intestinal functioning against damage, pending the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective Effect of Polysaccharides from Tussilago farfara L. on Bone Marrow Cells and Small Intestinal Epithelium Under Conditions of Polychemotherapy Evaluated by DNA Comet Assay by Safonova EA1, Lopatina KA2, Vychuzhanina AV2, Mashanova VA2, Razina TG2, Borovskaya TG2, Zueva EP2, Gur'ev AM3, Belousov MV. (PubMed)

0.1% #Glucoraphanin (a Glucosinolate precursor of SFN) Broccoli Processes Anti-Depression-Like Property, Researchers Show

Kyle J. Norton

Depression is a common and serious psychological illness, that affects the physical and mental functions of patients, including the patients feeling, thinking, and actions.

Some patients with depression may feel sadness and/or a loss of interest in activities once enjoyed.

There is no exact cause of depression. Changes in hormone levels, medical conditions, stress, grief, or difficult life circumstances that initiate the change of brain chemistry in inducing depressive syndrome are some of the most prevalent factors found in patients with depression.

The most common symptoms of depression include sadness, hopelessness, guilt, change of mood, and loss of interest in friends, family, favorite activities, and sex.

In severe cases, some patients with depression also experience cognitive symptoms of trouble concentrating, making decisions, remembering, and thoughts of harming themselves.

According to the statistics provided by the Anxiety and Depression of Association of Americans, major depressive disorder is the leading cause of disability in the U.S. for ages 15 to 44.3, affecting more than 16.1 million American adults, or about 6.7% of the U.S. population age 18 and older.

Conventionally, selective serotonin reuptake inhibitors (SSRIs) are the primary medication for the treatment of depression due to their relatively lower side effects compared to depressants. Other types of antidepression medication may include serotonin-norepinephrine reuptake inhibitors (SNRIs), typical antidepressants, and monoamine oxidase inhibitors (MAOIs).

Dr. Steven S. Clevenger and colleagues in examining the role of selective serotonin reuptake inhibitors in the relapse risk of major depressive disorder wrote, "According to the included studies, the relapse risk in adults was lower when SSRIs were combined with psychotherapy".

And, " the combination of SSRIs and cognitive behavioral therapy may effectively reduce relapse. Escitalopram appeared to yield better results and fewer side effects than did other SSRIs or SNRIs".
On finding a potent compound that processes depressant-like activity, researchers examined the effects of Sulforaphane (SFN), an isothiocyanate compound derived from broccoli on inflammation-related depressive symptoms.

On lipopolysaccharide, (LPS, 0.5 mg/kg) induced depression-like behavior in mice, pretreatment SFN showed a significant effect in the blockage of the increase in the production of pro-inflammatory cytokine (tumor necrosis factor-α (TNF-α)) level and an increase in microglial activation of the brain associated with the inflammatory response by increasing the expression anti-inflammatory cytokine IL-10.

Activation of microglia is a hallmark of brain diseases.

In the tail suspension test and forced swimming test, immotility caused by the LPS of the tested mice was also attenuated by the injection of SFN.

Degeneration of cognition in the brain caused by the alternation of the density of the proteins associated with the brain functioning due to the LPS was also restored by the SFN.

More importantly, dietary intake of 0.1% glucoraphanin (a glucosinolate precursor of SFN) food in juveniles and adolescents has been found to prevent the risk of LPS-induced depression-like behaviors and dendritic spine changes in the brain regions in adulthood.


In other words, SFN isolated from the rich broccoli sprout exhibited depressant-like activity that was attributed to the anti-inflammatory property.

Based on the findings, researchers said, "supplementation of SFN-rich broccoli sprout could be a prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients".

Taken altogether, broccoli sprouts rich in SFN may be considered a functional food for the treatment of depression, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation by Zhang JC1, Yao W1, Dong C1, Yang C1, Ren Q1, Ma M1, Han M1, Wu J1, Ushida Y2, Suganuma H2, Hashimoto K. (PubMed)
(2) The role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder by Steven S. Clevenger, Devvrat Malhotra, Jonathan Dang, Brigitte Vanle, and aguish William Ishak. (PMC)

#Lentil Inhibits Diseases Associated with Overexpression of Pro-Inflammatory Factors, Researchers Suggest

Kyle J. Norton

Lentil may have a profound and positive effect in modulating the immune response in the acute phase of infection, some scientists suggested.

Lentil is a type of pulse and tiny legume that can be cooked quickly and rich in protein and fiber, belongings the genus Lens of the Fabaceae family, native to the Middle East.

The immune response is a natural reaction of the immune system to protect our body against the invasion of foreign substances.

In the acute phase of infection, the immune system initiated the production of proinflammatory Th1 cytokines in activated interleukin-12 (IL-12) and gamma interferon (IFN-γ) and other pro-inflammatory factors such as TNF beta in response to detect, engulf and destroy pathogens and apoptotic cells through macrophages.

These activities played an important in inducing apoptosis and reducing the proliferation of bacteria or viruses by attaching to the surface of the injured cells to initiation of an alternation. however, overproduction of pro-inflammatory expression may indeed cause substantial adverse effects in tissue destruction, and, in some cases, shock and death.

Type 1 T helper (Th1) in response to tissue damage and injury also activated macrophages that are responsible for cell-mediated immunity and phagocyte-dependent protective activity.

In the concerns of lectins, adverse effects may pose a potential threat to consumers due to their capacity to induce histamine release from basophils, after investigating over 16 common dietary products containing lectins researchers found that most plant lectins induce human basophils to produce interleukin 4 (IL-4) an anti-inflammatory cytokine, which plays an important role in stimulated secretion of T cells and IL-13 another cytokines works conjunction with IL-4 in promoted the expression of T helper 2 (Th2) responses and regulation of Immunoglobulin E (IgE) synthesis.

All these expressed a significant effect of dietary lectin in reduced overexpression of pro-inflammatory factors in the immune system during the acute phase of infection in induced further cell damage and death in the infectious site through secretion of anti-inflammatory cytokines without decreasing the immune protective activities.

Truly, further examine also found that concanavalin A, lentil lectin, and phytohemagglutinin, , triggered basophils to release IL-4 at concentrations of up to 1 ng/10(6) basophils which in turn orchestrated the release of IL-13 and histamine and levels of IL-4 and IL-13 release reached a maximum after 4-6 h and more than 18 h, after injection, respectively.

These activities demonstrated a significant effect of lentil lectin in inducing early IL-4 required to switch the immune response towards a Th2 response and type I allergy, involving immunoglobulin E (IgE)–mediated release of histamine and other mediators from mast cells and basophils.

Indeed, the relative balance between Th1 and Th2 cytokines appears crucial, as Th1 cells activated immune response during the early state of body injury or damage through evoking cell-mediated immunity and phagocyte-dependent inflammation, in stimulated production of several pro-inflammatory cytokines such as interferon (IFN)-gamma, interleukin (IL)-2 and tumor necrosis factor (TNF)-beta which may also cause damage to the cell of the infectious region, leading to permanently additional damage to the tissues and Th2, under response to overexpression of pro-inflammatory cytokines stimulated the production of IL-4, IL-5, IL-6, IL-9, IL-10, and IL-13 of anti-inflammatory cytokines in evoked strong antibody responses (including those of the IgE class) and eosinophil accumulation, and inhibited several functions of phagocytic cells as indicated above.

Taken together, Lentil lectin may have an anti-inflammatory effect in reducing the overexpression of pro-inflammatory factors in the initiation of symptoms of fever, headache, swelling, redness, loss of appetite, and muscle stiffness through activating the production of anti-inflammatory cytokines.


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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Role of Th1 and Th2 Cytokines in Immune Response to Uncomplicated Plasmodium falciparum Malaria by Donato Torre,1,* Filippo Speranza,1 Massimo Giola,1 Alberto Matteelli,2 Roberto Tambini,1 andGilberto Biondi1(PMC)
(2) Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils by Haas H1, Falcone FH, Schramm G, Haisch K, Gibbs BF, Klaucke J, Pöppelmann M, Becker WM, Gabius HJ, Schlaak M.(PubMed)
(3) T-cell subsets (Th1 versus Th2) by Romagnani S1(PubMed)

#Bromelain Porcesses Anti Immune-Hypersensitivity by Inhibiting Airway Inflammation, Researchers Say

Kyle J. Norton

Inflammation is a natural defense of the immune system that tries to protect the body against the insult from foreign invasion.

Acute inflammation occurs quickly or within hours and lasts a few days or weeks and the damaged tissues are healed themselves after all pathogens are killed off.

However, if the immune system can not completely eradicate all invaders in the acute phase of infection, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.

Airway inflammation is a lung inflammatory caused by both allergens and immune mistakenly attacks the respiratory tissues.

Chronic airway disease predominantly asthma and chronic obstructive pulmonary disease (COPD) have increased at an alarming rate in the US over the past 20 years.

According to the statistics provided by the WHO, globally, approximately 65 million people suffer from chronic obstructive pulmonary disease (COPD), causing the death of 3 million each year. and 334 million people suffer from asthma, affecting 14% of all children globally.

In the US, the prevalence of chronic airway disease was found to cause a major financial burden to society, with both direct and indirect costs.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to discover a natural compound for the treatment of airway inflammation, researchers examined the benefits of alternative asthma treatments, including the ability of bromelain to inhibit inflammation, accompanied by a lifestyle change.

Preexisting asthma via ovalbumin (OVA)-an induced murine model of allergic airway disease (AAD) selected to the investigation were randomly assigned to receive phosphate-buffered saline (PBS) only or bromelain in PBS.as an intervention group.

According to the results of the sensitized female C57BL/6J mice with intraperitoneal OVA/alum and then challenged with OVA aerosolization for 10 consecutive days followed by administering daily doses of PBS to the control group (n = 10) and bromelain (6mg/kg) in PBS to the bromelain (intervention) group (n = 10) on day 4, the intervention group demonstrated a significant increase of anti-inflammatory activity observed by the reduced BAL total leukocytes (P < .05), eosinophils (P < .05), and cellular infiltrates via lung pathology (P < .005), compared to the control group.

Interestingly, bromelain significantly reduced BAL CD4+ and CD8+ T cells ratio without affecting cell numbers in the spleen or hilar lymph node, an indication of reduced hypersensitivity of the immunity.


In other words, bromelain protects airway inflammation in asthmatic animals by inhibiting the production of pro-inflammatory cytokines through its anti-inflammation property.

Based on the findings, researchers wrote, "bromelain has a therapeutic effect in established AAD, which may translate into an effective adjunctive therapy in patients with similar conditions, such as allergic asthma, who have chosen to initiate treatment after the onset of symptoms".

Also, according to the results of another study included ovalbumin (OVA)-induced murine model of allergic airway disease (AAD) assigned to either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days., bromelain treatment of AAD mice exerted a similar effect compared to the aforementioned experiment.

Bromelain reduced total BAL leukocytes, eosinophils, CD4+ and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13, through its anti-inflammatory activity.

Dr. Secor ER Jr, the lead scientist wrote in the final report, "The reduction in AAD outcomes suggests that bromelain may have similar effects in the treatment of human asthma and hypersensitivity disorders".

Taken altogether, bromelain may be considered supplements for the prevention and treatment of allergic airway inflammation, pending the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease by Secor ER Jr1, Carson WF 4th, Cloutier MM, Guernsey LA, Schramm CM, Wu CA, Thrall RS. (PubMed)

#Herbal #Catsclaw Reduces the Chemotherapy Adverse Effects Against #BreastCancer, According to Studies

Kyle J. Norton

Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae, used in traditional medicine for over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc.

Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

There are also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.

A recent study of prevention in experimental diabetes suggested that Uncaria tomentosa (Willd.) may be effective in reducing the risk and treatment of breast cancer.


Hydroalcoholic extract of U. tomentosa is found to associate with a reduction of accelerated tumor progression through many biological aspects.

A study of C57BL/6 male mice injected with MLDS (40 mg/kg) and orally treated with UT at 10-400mg/kg during 21 days, showed a higher number of intact islets and a significant inhibition of destructive insulitis, and significant protection against the loss of insulin-secreting presented β-cells.

The plant also expressed a high level of modulation of the immune system. Immunomodulatory properties of medicinal plants showed to mitigate breast cancer cell growth, through immune cell types participating in the process, especially cytotoxic T cells and natural killer cells, and cytokines.
In MT-3 and MCF7 cell lines, U. tomentosa also exhibited antiproliferative, cytotoxic, cytostatic, and anti-inflammatory activity as well as mutagenic and antimutagenic properties.

Dr. Baraya YS, the lead author said, "Curcuma longa was reported to hold strong potential in breast cancer treatment in various parts of the world. Interestingly, research findings have shown that these plants possess bioactive immunomodulators as their main constituents producing the anticancer effects".

Furthermore, in vitro, immunomodulatory effects of a Uncaria tomentosa hydroalcoholic extract exhibited an anti-breast cancer effect by increasing the production of cytokines related to the anti-tumoral response at concentrations of 500-1000 μg/mL.


In a randomized clinical trial of treatment for breast cancer, Uncaria tomentosa (Ut) not only reduced the adverse effects of chemotherapy but also enhanced immunological parameters, antioxidant enzymes, and attenuated oxidative stress caused by cellular DNA damage.

The herbal plant, Cat's claw has shown its effects in the treatment of breast cancer through many aspects, but the use of the plant must be only given by herbalists, as the quality and quantity may be different due to geography, time of harvest, and where the plant was grown.


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Sources
(1) Uncaria tomentosa extract alters the catabolism of adenine nucleotides and expression of ecto-5'-nucleotidase/CD73 and P2X7 and A1 receptors in the MDA-MB-231 cell line. by Santos KF1, Gutierres JM2, Pillat MM3, Rissi VB4, Santos Araújo MD5, Bertol G6, Gonçalves PB4, Schetinger MR2, Morsch VM7(PubMed)
(2) The Immunomodulatory Potential of Selected Bioactive Plant-Based Compounds in Breast Cancer: A Review by Baraya YS1, Wong KK2, Yaacob NS3(PubMed).
(3) [Immunomodulation of Uncaria tomentosa over dendritic cells, il-12 and profile TH1/TH2/TH17 in breast cancer].[Article in Spanish]by Núñez C1, Lozada-Requena I1, Ysmodes T1, Zegarra D1, Saldaña F1, Aguilar J1.(PubMed)
(4) Uncaria tomentosa-Adjuvant Treatment for Breast Cancer: Clinical Trial by Santos Araújo Mdo C1, Farias IL, Gutierres J, Dalmora SL, Flores N, Farias J, de Cruz I, Chiesa J, Morsch VM, Chitolina Schetinger MR.(PubMed)
(5) Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines by García Giménez D1, García Prado E, Sáenz Rodríguez T, Fernández Arche A, De la Puerta R.(PubMed)
(6) The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line by Riva L1, Coradini D, Di Fronzo G, De Feo V, De Tommasi N, De Simone F, Pizza C.(PubMed)

#Arctiin found in #Herbal #Burdock Roots and Seeds, Processes Anti #Diabetes and #DiabeticRetinopathy, According to Studies

Kyle J. Norton

Scientists may have found a herbal medicine for the prevention and treatment of diabetes with no side effects, according to studies.

Diabetes is a medical and chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

The disease is either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol.

Some researchers suggested that high blood cholesterol is one major risk factor that not only contributed to the risk of obesity but also facilitates the onset of diabetes.

How to calculate your blood cholesterol, If the ratio of your blood cholesterol is higher than 4, you have high blood cholesterol.

The normal ratio of blood cholesterol is 4 (low-density lipoprotein or bad cholesterol)/ 1 ( high-density lipoprotein or good cholesterol). Any number which is higher than 4 is considered high blood cholesterol.

How is high blood cholesterol associated with diabetes
* Most patients with diabetes also have a syndrome of high blood cholesterol.

* According to Dr. Michael Greger M.D. long-term intake of a high-fat diet is associated with diabetes. According to the study of young, healthy people and split them up into two groups, high fat intake within 2 days demonstrated, a significant rise of glucose intolerance. During the study, the high-fat diet group ended up with twice the blood sugar compared to the carbohydrate-rich diet group.

* Also the spike of blood sugar in the high-fat diet group may also increase the onset of insulin resistance due to insulin no longer performing its function in activating the function of the insulin receptors site which is now clogged up by cholesterol to stimulate the enzymes associated with glucose transport.

In other words, the pancreas beta cells will continue to produce insulin but can not lower the blood glucose due to the disruption of glucose metabolism, leading to insulin resistance, the major cause of diabetes.

Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro. Herbal medicine has been using thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and blood-purifying agent to treat wounds and infections stomach ulcers, and other digestive problems.

Too find a natural medicine for the treatment of diabetes and reduced diabetic retinopathy is one of the most common and severe complications of diabetes mellitus, researchers at the Third Military Medical University examined Arctiin, a bioactive compound isolated from the dry seeds of Arctium lappa L.(Burdock), antidiabetic activity.

Male Sprague-Dawley rats induced diabetes are randomly divided into five groups (n = 20 per group) and treated with intragastric doses of 30, 90, or 270 mg/kg/d wt of arctiin, 100 mg/kg/d wt of calcium dobesilate, or 0.5 % CMC-Na and 20 nondiabetic sham-treated rats were treated with 0.5 % CMC-Na.

In the beginning, there was no significantly different occurrence of diabetic retinopathy among the groups.

However, at week 16, the glycosylated hemoglobin (HBA1c) level was significantly decreased in all of the arctiin-treated groups when compared with the control group, and the serum glucose level was also decreased in the rats treated with the highest dose of arctiin

The normal levels of HbA1c of 6.5% and HbA1c are used as an objective measure of glycaemic control.

The highest dose of the arctiin group showed a decrease in the serum glucose level which was elevated by the induction of diabetes.

Arctiin treatment group displayed a reduced inflammation in the expression of retinal edema, detachment of the retina, and levels of pro-inflammatory cytokines observed by the histological and immunochemical examinations.

Furthermore, arctiin also increased the viability of retinal microvascular endothelial cells which was reduced in diabetic rats, in vitro.

Dr. Lu LC, the lead scientist wrote, "These findings demonstrate that arctiin decreases the severity of diabetic complications, demonstrating the importance of this compound as an inhibitor of diabetic retinopathy".

Additionally, in the review of the anti-diabetes effects of the active compounds present in the different botanical parts of burdock, researchers examined the active ingredients in the roots and seeds.

The results of the chemical analysis suggested that the compounds isolated from roots showed a strong effect in the inhibition of diabetes through their antioxidant activity.

In the seeds, some active compounds possess anti-inflammatory effects similar to that of arctiin treatment rats group.

These results suggested that herbal burdock exerted a strong anti-diabetes and diabetic complication through its glycaemic control and antioxidant and anti-inflammatory properties.


Taken together, herbal Burdock processed with high numbers of the bioactive compound may be considered a functional herb for the prevention and combined with the primary medicine for the treatment of diabetes and diabetic complication.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of arctiin on streptozotocin-induced diabetic retinopathy in Sprague-Dawley rats by Lu LC, Zhou W, Li ZH, Yu CP, Li CW, Luo MH, Xie H.(PubMed)
(2) A review of the pharmacological effects of Arctium lappa (burdock) by Chan YS1, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SM, Leung GP, Yu PH, Chan SW. (PubMed)
(3) Fat is the Cause of Type 2 Diabetes by Written By Michael Greger M.D. FACLM on November 17th, 2016. (Nutrition Facts)