Diet Rich in #Carotenoids is Associated with a Reduced Risk of #ChronicInflammatoryDiseases, Scientists Say

Kyle J. Norton

Inflammation is a natural defense of the immune system that protects the body against the insult from foreign invasion.

Acute inflammation occurs quickly or within hours and lasts a few days or weeks and the damaged tissues are healed themselves after all pathogens are killed off.

However, if the immune system can not completely eradicate all invaders in the acute phase of infection, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.

Chronic inflammation is a low-grade inflammation caused by the inability of the immune system to eliminate the invasive pathogens that occurred in the acute phase of infection.

Any inflammation that lasts more than 8 weeks is considered chronic inflammation.

Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.

In the US, chronic inflammatory diseases affect more than 50 million Americans each year.

Diseases associated with low-grade inflammation include diabetes and cardiovascular obesity, depression, and chronic pain.

Conventionally, Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common medical drugs such as aspirin. ibuprofen in reducing inflammation associated with pain-relieving.

In finding a potential phytochemical for the treatment of chronic diseases, researchers examined the relationship between dietary patterns, circulating carotenoid and tocopherol concentrations, and biomarkers of chronic low-grade systemic inflammation in a 10-year longitudinal study of Scottish postmenopausal women.

According to the assessment of FFQ during 1997-2000 (n 3237, mean age 54·8 (SD 2·2) years). Participants (n 2130, mean age 66·0 (SD 2·2) years) returned during 2007-11 for follow-up,

* The past 'prudent' dietary pattern showed a decrease in serum concentrations of hs-CRP and IL-6 (which decreased across the quintiles of the dietary pattern; P= 0·002 and P= 0·001, respectively; ANCOVA),

* The Inflammatory biomarker concentrations were decreased markedly across the quintiles of carotenoids component score (P< 0·001 for hs-CRP and IL-6, and P= 0·016 for E-selectin, compared to the increase of inflammatory biomarkers in contemporary dietary patterns.

* More precisely, prudent dietary pattern and carotenoid component scores were negatively associated with serum hs-CRP concentration (unstandardized β for a prudent component: -0·053, 95% CI -0·102, -0·003; carotenoid component: -0·183, 95% CI -0·233, -0·134).

Where, a prudent dietary pattern (which reflects a diet high in the intakes of fish, yogurt, pulses, rice, pasta, and wine, in addition to a fruit and vegetable-rich with carotenoids diet.

In other words, a prudent diet rich in carotenoids is associated with a reduced risk of chronic inflammatory diseases.

Taken together, carotenoids may be considered an adjunct therapy in the treatment of diseases associated with chronic low-grade inflammation, pending the confirmation of the larger sample size and multicenter human study.

Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Patterns of dietary intake and serum carotenoid and tocopherol status are associated with biomarkers of chronic low-grade systemic inflammation and cardiovascular risk by Wood AD1, Strachan AA1, Thies F1, Aucott LS1, Reid DM1, Hardcastle AC2, Mavroeidi A3, Simpson WG1, Duthie GG4, Macdonald HM. (PubMed)

#Lycopene Found in #Tomatoes Linearly is Associated with a Reduced Risk of #GastricCancer, Researchers Show

Kyle J. Norton

The stomach located between the esophagus and the small intestine is a muscular, hollow, and important organ of the digestive tract.
The stomach plays a critical role to assist the digestive system in digesting foods by secreting acid and enzymes.

Gastrointestinal injury is an injury associated with the stomach, small bowel, colon, or rectum.

In other words, any damage to the organs of the digestive system caused by blunt or penetrating trauma is considered a gastrointestinal injury.

Untreated Gastrointestinal injury has been found to increase the risk of cell alternation, leading to the onset of gastric cancer.

Gastric cancer or stomach cancer is a medical condition caused by irregular cell growth of the inner lining tissues of the stomach.

Most cancer of gastric starts in the cells on the inner lining of the stomach before penetrating into deeper layers.

At the advanced stage, cancerous gastric cells can also travel a distance away to an alternate DNA of healthy cells, leading a secondary metastasis.

According to the statistics provided by the Canadian Cancer Society, In 2017, approximately 3,500 Canadians were diagnosed with stomach cancer, and gastric cancer also caused the death of 2,100 including 1,300 women and 790 men.

Hyperproliferation is a progression of highly invasive tumors associated with an abnormally high rate of cancer cell division, leading to rapid overgrowth of the tumor.

The exact causes of gastric/stomach cancer are unidentified. The most common prevalent factors associated with increasing age (Most cases of gastric/stomach cancer are found in adults at fifty), are diet, bacterial infection, hydrochloric acid production, long-term inflammation of the stomach, family history, and smoking.

However, most people with some of the aforementioned risk factors have never developed gastric. stomach cancer.

Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In finding a potential compound for the treatment of gastric cancer, researchers examined the role of lycopene by searching MEDLINE and EMBASE to identify potential studies published from January 1966 to June 2012.

According to the mega reports, 21 studies that satisfied the inclusion criteria, were identified.
The findings suggested that the consumption of large amounts of tomato products by comparing the highest and lowest consumption groups reduced the risk of gastric cancer.

In other words, the decreased gastric cancer risk was linearly dependent on the volume of tomato consumed gaily and regularly.

Additionally, the relative odds ratio risk of gastric cancer was also decreased to 0.88 and 0.79 on lycopene consumption and serum lycopene, respectively.


More precisely, levels of lycopene in the blood induced by chronic intake of tomato were also linearly depending on the amount of consumption daily.

Based on the results, researchers suggested, consumption of large amounts of tomato products daily and regularly induced high levels of lycopene in the blood is associated with a reduced risk of gastric cancer.

Taken together, lycopene found in tomatoes may be considered supplements for the prevention and treatment of gastric cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anticancer Effect of Lycopene in Gastric Carcinogenesis by Kim MJ1, Kim H. (PubMed)
(2) The role of tomato products and lycopene in the prevention of gastric cancer: a meta-analysis of epidemiologic studies by Yang T1, Yang X, Wang X, Wang Y, Song Z. (PubMed)

#Moronicacid Processes Anti-Diabetes and Anti-Hyperglycemic Action, Researchers Suggest

Kyle J. Norton

Antihyperglycemic activity is the process that promotes a hypoglycemic effect against the progression of hyperglycemia.

Oral antihyperglycemic agents are medications used to lower glucose levels in the blood in the treatment of diabetes mellitus.

Hyperglycemia, a medical condition of abnormally high blood glucose and a hallmark of diabetes, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly.

Untreated hyperglycemia has been found to induce ketoacidosis characterized by the symptoms of shortness of breath, breath that smells fruity and gastrointestinal discomforts such as nausea, vomiting, and dry mouth.

Ketoacidosis is a life-threatening condition caused by your body's inability to make enough insulin.

Most cases of hyperglycemia can be controlled by following diabetes guidance.

By eating a healthy diet high in fiber, such as vegetables, fruits, nuts, legumes (beans, peas, and lentils), whole-wheat flour, and wheat bran, accompanied by healthy fish, patients with type 1 and 2 diabetes can control their blood glucose without worrying the onset of hyperglycemia.

The most common diseases associated with untreated hyperglycemia are cardiovascular diseases,
nerve damage (neuropathy) and kidney damage (diabetic nephropathy) or kidney failure and damage to the blood vessels of the retina (diabetic retinopathy), potentially leading to blindness.


Moronic acid is a phytochemical in the subclass of Triterpenoid, belonging to the group of Terpenes found extracted from Rhus javanica, Mistletoe, etc.

In finding a potential phytochemical for the treatment of high blood glucose, researchers examined the effects of Morolic (1) and moronic (2) acids, the main constituents of acetonic extract from Phoradendron reichenbachianum (Loranthaceae), a medicinal plant on hyperglycemia.

In mice induced diabetic model,* Daily-administered morolic (1) and moronic (2) acids (50 mg/kg) significantly lowered the blood glucose levels by 60% from the first day until the tenth day after treatment than the untreated group (p<0.05).
* Both compounds diminished plasmatic concentration of cholesterol (CHO) and triglycerides (TG), returning them to normal levels (p<0.05).

* Pretreatment with 50 mg/kg of each compound induced a significant antihyperglycemic effect after glucose and sucrose loading (2 g/kg) compared with the control group (p<0.05).

* Moreover, in vitro studies showed that compounds 1 and 2 induced inhibition of 11β-HSD 1 associated with hepatic glucose output activity at 10 μM.


Based on the findings, researchers said, "moronlic and moronic acids have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol, and triglycerides, in part mediated by inhibition of 11β-HSD 1".

Taken together, moronic acids may be considered supplements for the treatment of hyperglycemia, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihyperglycemic and sub-chronic antidiabetic actions of morolic and moronic acids, in vitro and in silico inhibition of 11β-HSD by Ramírez-Espinosa JJ1, García-Jiménez S, Rios MY, Medina-Franco JL, López-Vallejo F, Webster SP, Binnie M, Ibarra-Barajas M, Ortiz-Andrade R, Estrada-Soto S. (PubMed)

#Ginger Exhibits Anti Oral Cancer Activity through Its Proapoptotic Factors and Anti Cell Survival Mechanisms, Researchers Say

Kyle J. Norton

Scientists may have found a natural remedy for the prevention and treatment of oral cancer with no side effects, according to studies.

Oral cancer also known as mouth cancer is a medical condition characterized by irregular cell growth in the tissue of the oral cavity, due to the alternation of cell DNA.

Most cases of oral cancer begin in the cells on the surface of the inner lining of oral tissue.

However, at the advanced stage, oral cancer cells can travel a distance away to infect other healthy tissue and organs, leading to secondary metastasis.

According to the statistic provided by the American Cancer Society, in 2018, approximately 51,540 people were diagnosed with oral cavity or oropharyngeal cancer. The disease causes the death of an estimated 10,030 people.

The 5-year survival rate of oral cancer is 66%, including all stages.

Family history, smoking, alcohol drinking, being infected by the HPV virus, poor hygiene, and genetic preposition are some of the risk factors associated with the disease.

Some researchers suggested that oral sex may be one of the major prevalent risk factors involved in the development of oral cancer. Dr. Rajiv Saini in the examination of the connection of oral sex and oral cancer, wrote, "The diverse conduit in the oral cavity that provides as a gateway of exposure of infection from the oral cavity to bloodstream include any open sores, cuts, abrasions, or bleeding gum disease such as gingivitis and periodontitis".

"Accumulating molecular and pathologic evidence has strengthened the hypothesis that HPV infection could play a role in the etiology of some oral squamous cell carcinomas.

And, "To reduce the risk of infection during unprotected oral sex, limit exposure to sexual fluids and ensure that no cuts or lesions are present in the mouth or on the genitals. Good oral health, free from bleeding gums, lip sores, cuts, broken skin, and oral epithelium, enormously reduces the chances of transmission of infection among the partners indulging in oral sex".

These results strongly suggested people who perform oral sex before, during, and after sexual intercourse may be at risk of oral cancer due to being infected by the HPV virus.

Researchers on finding a natural compound for the inhibition of oral cancer examined the [6]-Shogaol ([6]-SHO), a major constituent of ginger anti-tumor activity.

[6]-SHO showed a significant effect in preventing oral squamous cell carcinoma by activating proapoptotic factors in vitro and in vivo experimental models.

In the inflammation and cell proliferation assays, injection of [6]-SHO inhibited the oral cancer cell line through cytotoxicity induced by the expression of proinflammatory cytokines, proteins associated with cell apoptosis, and anti-cell survival mechanisms.

Furthermore, in the oral cancer cells, oral administration of [6]-SHO strongly inhibited phosphorylation in stimulating the enzymes which carry energy to the cancer cells and enzymes in the degradation of cellular response to inflammation.

Dr. Annamalai G, the lead scientist said, " [6]-SHO is a novel functional agent capable of preventing DMBA-induced inflammation and cell proliferation-associated tumorigenesis by modulating multiple signaling molecules".

Additionally, in order to reveal more information about 6-Gingerol anti-oral cancer properties, researchers investigated the compound in human oral (SCC4, KB) with or without wortmannin, rapamycin, and cisplatin.

6-Gingrol showed dose-dependent cytotoxicity in the oral cell line.

Combinations of 6-gingerol with wortmannin and cisplatin showed additive effects, while rapamycin, it showed 50% cytotoxicity equivalent to that of IC50 of 6-gingerol alone.

Treatment with 6-gingerol exhibited S-phase arrest in SCC4 cells. But 6-Gingerol, wortmannin, and rapamycin treatment showed almost two-fold higher expression of proteins associated with cancer cell apoptosis.

Dr. in the final report wrote," 6-gingerol appears to be a safe and potent chemotherapeutic/chemopreventive compound acting through cell cycle arrest and induction of apoptosis in human oral....cells".

Taken together, ginger processed bioactive ingredient 6-gingerol and [6]-Shogaol may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of oral cancer, pending the confirmation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.




Sources
(1) [6]-Shogaol attenuates inflammation, cell proliferation via modulate NF-κB and AP-1 oncogenic signaling in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis by Annamalai G1, Suresh K. (PubMed)
(2) 6-Gingerol Mediates its Anti Tumor Activities in Human Oral and Cervical Cancer Cell Lines through Apoptosis and Cell Cycle Arrest by Kapoor V1, Aggarwal S1, Das SN. (PubMed)
(3) Oral sex and oral cancer: A virus link by Rajiv Saini. (PMC)

#Bromelain Reduces Neutrophil Migration Against the Initiation of Inflammation, According to Studies

Kyle J. Norton

Acute inflammation is a natural response of the immune system to protect the human body against harmful stimuli and pathogens.

Acute information is the first phase of injection. At this phase, after sensing the body injury by the central nervous system, the immune first line of defense stimulates the production of blood platelets to cover the site of damage and pro-inflammatory to kill off pathogens that try to enter the body through the wound or damaged tissue.

Acute inflammation usually receded after a few days or weeks depending on the size and damage. However, if all pathogens were not eradicated after 3 to 8 weeks, the immune system will compromise, leading to chronic low-grade inflammation, a leading cause of chronic illness.

The most common symptoms of acute inflammation occurred within a short period of time such as hours pain, redness, immobility, swelling, and heat.

Conventionally, depending on the types of acute inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) may be prescribed to alleviate the pain by counteracting an enzyme that contributes to inflammation.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

In finding a potential compound for the treatment of acute inflammation, researchers examined the effect of bromelain, a mixture of proteases derived from pineapple stem on inflammatory diseases, including murine inflammatory bowel disease.

According to the tested assays,* In vitro, bromelain modulated immune activity by removing a number of cell surface molecules that are vital to leukocyte trafficking.
* Bromelain inhibited neutrophil migration to IL-8 and decreased acute responses to inflammatory stimuli in the initiation of the production of pro-inflammatory cytokines.

* In vivo, bromelain treatment generated a 50-85% reduction in neutrophil migration in 3 different murine models of leukocyte migration into the inflamed peritoneal cavity through its anti-inflammatory properties.

In other words, through its anti-inflammatory activity, bromelain inhibited the primary long-term effect on the abrogation of firm adhesion of leukocytes to blood vessels at the site of inflammation in the induction of inflammation.

Additionally, in an ovalbumin (OVA)-induced murine model of acute allergic airway disease (AAD) with female C57BL/6J mice sensitized with intraperitoneal (i.p.) OVA/alum and then challenged with OVA aerosols for 3 days, administration of 200 mg/kg bromelain twice daily for four consecutive days, exerted a significant anti-inflammatory activity against the overexpression of pro-inflammatory cytokines caused by the injection of ovalbumin (OVA).

Interestingly, bromelain also inhibited allergic inflammation by modulating the immune response against ovalbumin (OVA).

Based on the findings, researchers wrote, " these studies demonstrate that bromelain can effectively decrease neutrophil migration to sites of acute inflammation".

Taken altogether, bromelain may be considered supplements for the prevention and treatment of acute inflammation, pending the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain treatment decreases neutrophil migration to sites of inflammation by Fitzhugh DJ1, Shan S, Dewhirst MW, Hale LP. (PubMed)
(2) Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma by Secor ER1, Carson WF, Singh A, Pensa M, Guernsey LA, Schramm CM, Thrall RS. (PubMed)

#Herbal Bilberry's #Anthocyanosides Enhances Retinal Sensitivity by Improving Visual Acuity and Dark Adaptation, and Blood Supply of the Retina, Researchers Say

Kyle J. Norton

Eye disease is a general term of conditions associated with the damage of the optic nerve and impaired vision, including disease of the cornea and macular degeneration.

People with eye disease in the early stage may not have any symptoms. However, depending on the severity and location that affects the vision, people with eye disease at the advanced stage may experience symptoms of acute eye pain, hazy, blurred, or double vision, seeing flashes of light, or sudden bright floating spots.

If you have some of the aforementioned symptoms, you may have eye disease. Please make sure that you check with your doctor to rule out the possibility.

Most common eye problems are minor and will go away on their own such as red-eye and eye strain. However, some eye problems may require medical attention such as vision change.

According to the statistics, the financial burden of vision loss and eye diseases, and vision disorders in the U.S. has taken a toll on healthcare costs. Approximately, $130 billion a year are spent to treat eye disease.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as an herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

In the urgency to find a natural source of the compound for the treatment of eye disease, particularly in the older population, researchers investigated the effects of bilberry anthocyanosides (Vaccinium myrtillus L.).

Bilberry anthocyanosides were found to promote rhodopsin, a biological pigment found in the rods of the retina synthesis and regeneration.

Moreover, the compounds increased retinal sensitivity to changes in light intensity and improved the visual acuity and dark adaptation, and blood supply of the retina.

The findings support the regular use of bilberry anthocyanosides as a dietary source against age-related macular degeneration, diabetic retinopathy, primary open-angle glaucoma, and other diseases.

Additionally, in order to reveal more information about bilberry bioactive compound properties, researchers evaluated the effect of Ginkgo biloba extract (GBE) and anthocyanins on visual function in patients with normal-tension glaucoma (NTG) based on the vascular theory of mechanisms of glaucomatous optic nerve damage.

332 subjects data (209 men and 123 women) treated with anthocyanins (n=132), GBE (n=103), or no medication (control, n=97) were reviewed.

According to the tested assays, the mean anthocyanin treatment duration was 24.32±10.43 (range, 6-53) months, and the mean GBE treatment duration was 23.81±10.36 months (range, 6-59) months.

After anthocyanin treatment, the mean best-corrected visual acuity (BCVA) for all eyes improved from 0.16 logMAR units, and Humphrey Visual Field (HVF) mean deviation improved from -6.44.

Dr. Shim SH, the lead scientist said, "These results suggest that anthocyanins and GBE may be helpful in improving visual function in some individuals with NTG".

Taken altogether, bilberry-processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the prevention and treatment of eye diseases, pending the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) [Current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases].[Article in Russian; Abstract available in Russian from the publisher] by Vorob'eva IV1, Vorob'eva IV. (PubMed)
(2) Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma by Shim SH1, Kim JM, Choi CY, Kim CY, Park KH. (PubMed)

#GammaLinolenicAcid #GLA Processes Anti-Atherosclerotic Lesions by Modulating a Profile of Eicosanoid Production in Vivo

Kyle J. Norton

Atherosclerosis is a medical condition caused by plaques accumulating on the wall of the arteries, leading to the narrowing of the arteries in transporting oxygenated blood to the heart and other parts of the body.
Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.

Plaque is the made of cholesterols, calcium, and other toxic substances, including cadmium.

Atherosclerosis is a slow, progressive disease that may begin as early as childhood, caused by damage to the inner lining of the artery. However, the actual causes of the condition are debatable.

Some researchers suggested that atherosclerosis may be caused by long-term high blood pressure,
high cholesterol, and triglycerides (a type of fat) in the blood. Particularly, in high levels of insulin in the blood from diabetes and in exposure to chemicals from smoking tobacco.

Patients with early stages of atherosclerosis may not experience any symptoms. However, as the disease progress, patients may have the symptoms of chest pain if the blockage occurs in an artery of the heart (coronary artery) and leg cramps during exercise or walking if the blockage occurs in the legs.

According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, the coronary heart disease mortality rate was about 60%.

Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease, and physical inactivity, particularly smoking.

Some researchers suggested that since cholesterol makes up a big part of the plaque, an unhealthy diet with high saturated trans fat, red meat, and processed meat may be the major cause of atherosclerosis.


Gamma-linolenic acid is a phytochemical in the group of Omega-3, 6,9 fatty acids, belongings to the class of Lipids, found abundantly in evening primrose, borage, blackcurrant, etc.

In finding a potential plant for the prevention and treatment of atherosclerosis, researchers examined the effect of the effects of D5D inhibition by a D5D inhibitor on atherosclerosis.

Where Delta-5 desaturase (D5D), encoded by fatty acid desaturase 1 (Fads1), is the rate-limiting enzyme for the conversion from dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA) in the ω-6 polyunsaturated fatty acid pathway.


According to the results of the analysis of the Western-diet fed ApoE knockout (KO) mice,
* Oral administration of compound-326 (3-10 mg/kg per day for 15 weeks) significantly inhibited the progression of atherosclerotic lesions in the aorta without affecting plasma total cholesterol and triglyceride levels.

* Compound-326 significantly decreased AA levels, while it increased DGLA levels in the liver and the blood accompanied by decreases in AA-derived eicosanoid production and increases in DGLA-derived eicosanoid production from the blood cells.

In other words, compound-326 prevents the progression of atherosclerosis in Western-diet-fed ApoE KO mice by modulating a profile of eicosanoid production.

Collectively, researchers said, "D5D inhibitors can be a novel remedy for preventing atherosclerosis and subsequent cardiovascular events".

Taken together, Gamma-linolenic Acid may be considered a remedy for the prevention and treatment of atherosclerotic lesions,, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Novel Orally Available Delta-5 Desaturase Inhibitor Prevents Atherosclerotic Lesions Accompanied by Changes in Fatty Acid Composition and Eicosanoid Production in ApoE Knockout Mice by Takagahara S1, Shinohara H2, Itokawa S2, Satomi Y2, Ando A2, Yamamoto T2, Suzuki H2, Fujimoto T2, Kubo K2, Ikeda S. (PubMed)