#Turmeric Inhibits the Adiponectin Expression Against the Onset of Non-Small Cell Lung Cancer Cells In Vitro

Kyle J. Norton

Cancer is a class of medical and chronic diseases caused by irregular cell growth due to the alternation of cell DNA in the tissue of a specific organ.

Cancer cell that grows and multiply disorderly and uncontrollably over time can induce the forming of tumor after penetrating deeper layers of the infected organ tissue.

At the advanced stage, most invasive tumors can travel a distance away to infect other organs in the body via lymph or blood.

The lung is a vital organ located near the backbone on either side of the heart with the function of inhaling oxygen from the air before passing them to other parts of the body and exhaling carbon dioxide from the bloodstream.

Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells.

According to the statistics provided by the American Cancer Society, lung cancer is by far the leading cause of cancer death among both men and women in the US. Believe it or not, each year, more people die of lung cancer than of colon, breast, and prostate cancers combined.

Most people diagnosed with lung cancer are 65 or older, compared to a very small number of those younger than 45.

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, that usually grows and spreads methodically and predictably including
* Squamous-cell carcinoma is a type of NSCLC often found in an outer area of the lung.

* Large-cell carcinoma is a type of NSCLC found in the center of the lung by an air tube.

* Adenocarcinoma is the type of NSCLC found in any part of the lung.

Dr. Paris D. Makrantonakis, the lead scientist in examined the correlation of NSCLC risk and treatment in the elderly wrote, "The population is aging both in developing and developed countries. What is clear is that currently, over 50% of all patients with non-small cell lung cancer (NSCLC) are 65 years of age or older".

And, "recently published studies have focused on the issue and have provided strong evidence of improved progression-free survival, overall survival, and quality of life in elderly patients with appropriately treated NSCLC".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In finding a potential ingredient for the treatment of non-small cell lung cancer (NSCLC), researchers examined the effect of curcumin on the expression of adiponectin in paired tumors and normal lung tissues from 77 patients with NSCLC.

Epidemiologically, patients with low adiponectin expression ratio (<1) were found to have significantly longer survival time compared to those with a high expression ratio and adiponectin may be a prognostic indicator of NSCLC.


Administration of curcumin showed to inhibit the migratory and invasive ability of A549 cells by inhibiting the adiponectin expression.

Furthermore, Curcumin treatment also inhibited the in vivo tumor growth of A549 cells associated with the adiponectin expression.

More precisely, the efficacy of curcumin that inhibits the NSCLC was attributed to the mediation of pathways involved in promoting tumor invasion.

Additionally, according to the Shanxi Province Tumor Hospital study, curcumin inhibited the A549 cell proliferation also was found by decreasing intracellular ROS levels and increasing SOD and gamma-glutamylcysteine synthetase (γ-GCS) activity passcode with cancer cells apoptosis.

The results strongly suggested that curcumin-induced reduction of A549 viability. by inhibiting the expression of oxidative stress.

Taken together, turmeric-processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of non-small cell lung cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway by Tsai JR1,2, Liu PL1, Chen YH3, Chou SH1,4, Cheng YJ5, Hwang JJ1,2, Chong IW. (PubMed)
(2) Curcumin inhibits the growth via Wnt/β-catenin pathway in non-small-cell lung cancer cells by Wang JY1, Wang X, Wang XJ, Zheng BZ, Wang Y, Wang X, Liang B. (PubMed)
(3) Non-Small Cell Lung Cancer in the Elderly by Paris D. Makrantonakis, Eleni Galani, and Peter G. Harper. (The Oncologist)

#Omega 3 Fatty Acids Improve the Immune Function by Regulating Immunoregulatory Cytokines, According to Studies

Kyle J. Norton

An immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens, including bacteria, viruses, parasites, etc., and tumor cells, including irregular cell growth, and cancer cells to keep us healthy.

In most cases, the immune system does a great job of keeping people healthy and preventing infections. But sometimes problems with the immune system can lead to illness and infection.

Although the immune system has done a great job in protecting us against foreign invasion, unfortunately, during the process of their functions, they may induce the production of free radicals and a chain of free radicals that can be harmful to our body.

Immunomodulatory activity is an action that improves the underactive immune function susceptible to the invasion of the foreign microorganism and inhibits the overactive immune system that causes autoimmune diseases.

In other words, depending on the substances that affect the immunomodulatory process, some may improve the immune function by modulating the genes involved in immune responses and protect the immune system against toxins or immunotoxic effects such as abnormal allergic reactions, others such as heavy metals can induce opposite effects.

In normal immunity, active immunity may also be artificially acquired active immunity is caused by the injection of the vaccine, a substance that contains antigen, and passive immunity is an auto-response of the immune system against infection through the production of antigen.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

In finding a potential phytochemical for the improvement of immune functioning, researchers examined the long-chain n-3 PUFAs (LCPUFAs) anti-atopic disease risk in infants.

The study included pregnant Sprague-Dawley rats randomly assigned to consume either SDA (3 g SDA/100 g fat) or a control (no SDA) diet, 5 d before parturition and through lactation (21 d).

Additionally, for oral tolerance (OT) treatment, 10-d-old pups were fed ovalbumin (Ova; 200 μL of 8 mg/mL) or placebo daily for 5 d. At 21 d,

According to the experimental results of pups (both sexes) that were weaned to their respective maternal diet until 6 wk of age and killed, the SDA-enriched maternal diet showed higher levels of plasma phospholipid (PL) EPA (15 times higher), docosapentaenoic acid (DPA; 3 times higher), and DHA (1.3 times higher) content in 3-wk-old pups, accompanied by higher B-cell function [plasma ovalbumin-specific IgG1, compared with the control diet.

Furthermore, compared with pups fed a control diet, the splenocytes from pups fed with the SDA diet had more (23%) helper T (Th) cells (CD3+CD4+) and activated (12%) Th cells (CD4+CD28+) (P < 0.02) than controls.

Moreover, at 6 wk, the SDA group stimulated ex vivo with LPS, also had 30% more CD4+CD25+ splenocytes and produced less inflammatory IL-6 (50%) and TNF-α (30%) and more immunoregulatory IL-10 (45%) cytokines, compared to the control group.

However, the splenocytes and plasma PLs from the 6-week-old SDA group had more EPA (2x) and DPA (3.5x) (P < 0.05), but not DHA, compared to the control group.

Additionally, the Ova-exposed group also had less (30%) plasma Ova-IgG1 than the placebo group.

Based on the findings, researchers said, "Feeding SDA during lactation and weaning altered immune responses in directions believed to be beneficial".

Taken altogether, Omega-3 fatty acids may be considered a functional food for the improvement of the immune response, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Feeding a Bioactive Oil Enriched in Stearidonic Acid during Early Life Influences Immune System Maturation in Neonatal Sprague-Dawley Rats by Patel D1, Goruk S1, Newell M1, Chen G1, Richard C1, Field CJ. (PubMed)

#Herbal #Coltsfoot inhibits the Production of Inflammatory Mediators and Cytokines by Suppressing the Immune Response

Kyle J. Norton

The immune system formed part of the body's defense plays a critical role in the protection of the body against infectious organisms.

The immune system executes the defense strategy through a series of immune response by attacking foreign substances that invade body systems.

A variety of factors have been found to trigger immune responses including pathogens, damaged cells, and toxic compounds.

Inflammation is a natural response of the immune system which protects the body against the invasion of pathogens.

In the acute phase of tissue damage or wound, the immune white blood cells of the first line of defense stimulate the production of a blood palette to cover the wound or damage and production of pro-inflammatory cytokines to the site of infection against microbial invasion.

Most cases of microbial invasion are stopped in the acute phase of infection, and the damaged tissue is slowly healing itself. However, in this phase, the overproduction of pro-inflammatory cytokines can lead to nearby cell death and the formation of scars.

If the immune system fails to destroy all microbial invasion in the acute phase of infection within a set period in 3 to weeks, it will compromise, leading to chronic low-grade inflammation.

The continued production of low levels of pro-inflammatory cytokines overtimes regardless of the causes can induce damage to organ tissues, and irreversible chronic diseases such as cardiovascular disease, diabetes, and cancer.

The Research Center for Molecular Medicine of the Austrian Academy of Sciences (Ce-M-M) wrote, "Humans have evolved highly complex immune systems that are composed of specialized immune cells that protect the host from infection and damage. But an uncontrolled immune response such as chronic inflammation can itself inflict damage".


And, "when the immune system is compromised by a genetic mutation, individuals become more susceptible to diseases such as autoimmune disease".

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used for thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

On finding a potential compound for the treatment of asthma and bronchitis, researchers examined the coltsfoot inhibitory effects on lipopolysaccharide-induced inflammation in macrophages.

In a cecal ligation and puncture (CLP)-induced mouse model of sepsis, Tussilagone suppressed the parameters associated with the production of pro-inflammation such as nitric oxide and prostaglandin E2, and the inflammatory cytokines, tumor necrosis factor-alpha (TNF-α), particularly in lipopolysaccharide-stimulated RAW 264.7 cells and peritoneal macrophages.

In other words, Tussilago inhibits the production of inflammatory mediators and cytokines by suppressing the immune response associated with the first line of defense.

Additionally, the administration of Tussilagone at doses of 1 mg/kg and 10 mg/kg) protects the lung cells by decreasing mortality and lung injury in CLP-activated septic mice.

Based on the findings, researchers said, " Tussilago exhibited protective effects against inflammation and polymicrobial sepsis by suppressing inflammatory mediators possibly via the inhibition of NF-κB activation and the MAP kinase pathway".

And, " These results suggest the possible use of Tussilago for developing novel therapeutic modalities for sepsis and other inflammatory diseases".

Taken altogether, coltsfoot may be considered a remedy for the treatment of inflammatory diseases associated with immune-inflammatory responses, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tussilagone Inhibits the Inflammatory Response and Improves Survival in CLP-Induced Septic Mice by Kim YK1, Yeo MG2, Oh BK3, Kim HY4, Yang HJ5, Cho SS6, Gil M7, Lee KJ. (PubMed)

Black Carrot Extract Inhibits Menopausal Symptoms, Induces Weight Loss and Prevents Obesity, Researchers Find

Kyle J. Norton

Carrots may have a profound and positive effect on reducing weight loss in the obese population, some scientists suggested.

Weight loss is an intentional action referred to by the medicine, health, or physical fitness communities as a reduction of the total body mass, including loss of fluid, body fat or adipose tissue, or lean mass.

Obesity is a condition or disease characterized by extreme weight. According to the Body Mass Index calculator, BMI between 25.0 to <30 is considered overweight and a BMI of 30.0 or higher, is considered obese.


According to the National Institue of Health, obese people are associated with a number of diseases and conditions, including diseases of coronary heart disease, type 2 diabetes, certain types of cancer, stroke, gallbladder disease, liver disease, certain types of respiratory disease, and infertility and conditions of high blood pressure, high total cholesterol or high levels of triglycerides, sleep apnea, and osteoarthritis.

Most researchers agreed that obesity is caused by a genetic mutation inherited from the parents, a long-term unhealthy diet with consumption of high amounts of energy foods, particularly fat and sugars, and physical inactivity.

Other causative factors also include certain medical conditions such as hypothyroidism and Cushing's syndrome and the long-term use of certain medications such as corticosteroids and antidepressants.

The general belief also suggested that some smokers may gain weight if they quit smoking.

According to the study conducted by the J University of Georgia, using a combined approach to promote nutrition and physical activity policies and practices in early care and education may reduce the risk of child obesity.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asia and Europe.

Estrogen-deficient animals with diet-induced obesity were examined in the study by the Obesity/Diabetes Center, Asan, Korea using black carrots to test the mechanisms of the long-term consumption of unfermented black carrot extract (BC) and its extracts fermented with Lactobacillus plantarum (BCLP) or Aspergillus oryzae (BCAO) in the prevention of menopausal symptoms including impaired energy, glucose, and lipid metabolism

During the experiment, ovariectomized (OVX) rats were fed four different high-fat diets containing 2 % dextrin (OVX-control), 2 % BC, 2 % BCLP, or 2 % BCAO for 12 weeks. Sham rats were fed high-fat diets containing 2 % dextrin.

Fat mass and weight gain in tested mice were lower in descending order of OVX-control > BC and BCLP > BCAO due to increased energy expenditure and fat oxidation.

BC, BCLP and especially BCAO all normalized HOMA-IR, an indicator of insulin resistance and glucose intolerance.

Furthermore, BCAO markedly decreased hepatic triglyceride levels by increasing gene expressions of CPT-1 and PPAR-α, which are involved in fatty acid oxidation, and decreasing mRNA expressions of FAS and SREBP-1c, which are associated with fatty acid synthesis.

More importantly, Cyanidin and malvidin markedly decreased fat accumulation in 3T3-L1 adipocytes by increasing CPT-1 and decreasing FAS expression in the liver fat metabolism and SREBP-1c expression in the regulation of the genes with the function of lipid metabolism in comparison with cyanidin-3-rutinoside, an anthocyanin, and malvidin-3,5-diglycosides, another anthocyanidin.

Where 3T3-L1 is a cell line derived from 3T3 cells used in biological research on adipose tissue.

These results suggested that unfermented black carrot extract (BC) and its extracts fermented with Lactobacillus plantarum (BCLP) processed an anti-obesity mechanism by preventing the exacerbation of lipid and glucose metabolism, the major causes of weight gain.

However, further data collection on large example size and multi-centers studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of carrot's anti-weight gain possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cyanidin and malvidin in aqueous extracts of black carrots fermented with Aspergillus oryzae prevent the impairment of energy, lipid, and glucose metabolism in estrogen-deficient rats by AMPK activation by Park S1, Kang S, Jeong DY, Jeong SY, Park JJ, Yun HS. (PubMed)

#Cabbage Regulates Expression and Transcription Associated with the Risk of #VascularInflammation, According to Studies

Kyle J. Norton

Blood vessels formed part of the circulatory system are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart. Atherosclerosis is characterized by chronic inflammation of the vascular wall.

Chronic vascular inflammation has been found to cause historical changes in the blood vessel walls, leading to blood vessel wall thickening, weakening, narrowing, or scarring on orchestrating blood flow restriction, resulting in organ and tissue damage.

Vasoprotection is the process to improve the function of the blood vessels, including the use of herbal and natural remedies.

Inflammation is a natural reaction of the immune system's self-protection to remove harmful stimuli, including damaged cells, irritants, pathogens... from our body.

Acute inflammatory inflammation is a result of the over-response of the immune system after sensing the injury or damage to the body by activating the protein associated with the production of pro-inflammatory cytokines.

The production of proinflammatory cytokines induced by the immune response is to kill the invasive pathogens, which try to enter the body through the wound.

In the acute phase of infection, the immune system in the stimulating production of proinflammatory cytokines may induce overproduction of these cytokines can cause death or damage to the nearby cells, leading to scar formation and symptoms of localized swelling, redness, and fever.

Chronic inflammation is a serious condition caused by the immune system's to adapt to the new change due to its inability to kill all the invasions within a set of times.


Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem which is crowded with a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find natural food that inhibits inflammation, researchers examined the anti-inflammatory activities of an anthocyanin-rich extract from red Chinese cabbage (ArCC).

According to the inhibitory effects in cultured endothelial cells and hyperlipidemic apolipoprotein E-deficient mice, ArCC treatment suppressed monocyte adhesion to tumor necrosis factor-α, the pro-inflammatory cytokines-stimulated endothelial cells.

Furthermore, ArCC's also processed the ability to downregulate the expression and transcription of endothelial adhesion molecules associated with the increased response to cytokines and other inflammatory mediators.

Moreover, the regulation of adhesion molecules was accompanied by transcriptional inhibition of nuclear factor-κB, which restricted cytoplasmic localization in triggering inflammation.

Additionally, Administration of ArCC (150 or 300 mg/kg/day) inhibited aortic inflammation in hyperlipidemic apolipoprotein E-deficient mice,


More precisely, ArCC markedly lowered leukocyte infiltration reduced plaque formation, and lowered concentrations of blood inflammatory cytokines compared to control mice.

Based on the results, researchers wrote, " ...the consumption of anthocyanin-rich red Chinese cabbage is closely correlated with lowering the risk of vascular inflammatory diseases.".

Taken altogether, Korean cabbage kimchi may be used for the treatment of vascular inflammation, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anthocyanin-Rich Extract from Red Chinese Cabbage Alleviates Vascular Inflammation in Endothelial Cells and Apo E-/- Mice by Joo HK1, Choi S2, Lee YR3, Lee EO4, Park MS5, Park KB6, Kim CS7, Lim YP8, Park JT9, Jeon BH. (PubMed)

#Fennel's #Anethole Reduces the Onset of Acute Inflammation and Chronic Inflammatory Diseases, Scientists Find

Kyle J. Norton

Fennel may process a strong anti-inflammatory activity in reducing the risk of tissue injury and cell apoptosis, some scientists suggested.

Acute inflammation is a natural and systematic immune response to protect our body against the invasion of foreign bacteria and viruses by the initiated production of inflammatory cytokines to the site of infection.

However, overproduction of pro-inflammatory cytokines initiated by the immune system for a prolonged period of time may lead to cell damage and sometimes death of the healthy cells in the infectious site and nearby cells.

These complications can also cause improper healing for the forming of scars and damage to the tissue of the organ, affecting and limiting the organs' functioning, such as liver scars caused by hepatitis virus infection.

Badly enough, some proteins process the duo functions of pro and anti-inflammation. Under abnormal conditions, they can switch from their original action of anti-inflammatory cytokines to pro-inflammatory cytokines.

Furthermore, chronic inflammation occurred that lasts for months or years when the immune system responds to the site of infection failing to eliminate agents that cause acute inflammation.

An autoimmune disorder attacks normal healthy tissue, mistaking them for pathogens that can also cause chronic inflammatory disease.
Most cases of inflammation, are treated with NSAID's, or non-steroidal anti-inflammatory drugs. However, in some people intake of these medications can cause common and serious side effects, including gastrointestinal issues, such as pain, constipation, diarrhea, gas, nausea, and stomach ulcers, kidney problems, anemia,.... and swelling in the leg.

If you are presently taking anti-inflammatory medicine, please make sure that you discuss the adverse effects with your doctor.

Fennel (Foeniculum vulgare) is a plant species, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.

The herbal medicine has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle and relieve PMS,...

According to a study of BALB/C mice were intraperitoneally administered anethole (62.5, 125, 250, or 500 mg/kg) 1 h before intratracheal treatment with LPS (1.5 mg/kg) and sacrificed after 4 h, researchers found that in anethole treatment group exerts a significant increase of numbers of mobile white blood cells macrophages and neutrophils, the first immune response to the infectious site.


Furthermore, the application of LPS also induced the production of inflammatory mediators such as matrix metalloproteinase 9 (MMP-9), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) all systematic inflammatory cytokines in response to cellular damage and tissue injury.

Moreover, LPS also exhibited overproduction of nitric oxide (NO) observed in bronchoalveolar lavage fluid in facilitated cellular cytotoxicity.


In the compared nontreatment group, the injection anethole group demonstrated a strong anti-inflammatory effect through decreased activities of proinflammatory factors without affecting the immune activity in protecting against infection.

Additional analysis also found that the treatment group reduced acute lung injury caused by the injection of LPS through its antioxidants and induced production of host natural antioxidants in the body tissue.

The inhibited LPS results according to were attributed to anethole effect in suppressing the activation of NF-κB in signaling the production of inflammatory cytokines by blocking the initiation of IκB-α degradation by inhibited TRAF2 in the induction of inflammation through TNF receptor superfamily members and NIK, a key signaling molecule of the noncanonical NF-κB.

Interestingly, further investigation of anethole as an inhibitor of TNF-induced NF-kB activation (an early response) as monitored by electrophoretic mobility shift assay, by suppression of IkBa phosphorylation and NF-kB reporter gene, researchers also indicated that

* Anethole also suppressed TNF-induced activation of the transcription factor AP-1 in regulated gene expression in response to a variety of stimuli, including LPS application.

*c-Jun N-terminal kinases (JNKs) with function in response to stress stimuli, such as cytokines,
And

* MAPKkinase in signals inflammatory response through transmitting information from a receptor on the surface of the cell to the DNA in the nucleus of the cell.


* Application of anethole also suppressed TNF-induced both lipid peroxidation and ROS generation, through the stimulated production of natural antioxidants in the host and itself, resulting in balancing the ratio of antioxidant and ROS expression.

The illustration and differentiation were elite by the experiment in the application of TNF (100 pM) with the cells pretreated for 240 and 120 min with anethole, NF-kB activation was almost completely inhibited.

However, the inhibition decreased gradually with decreased pre-incubation time.

Taken together, fennel and its bioactive anethole may be considered a functional food in reduced risk and treatment in acute and chronic inflammatory-related diseases through the properties like a pro-antioxidant and anti-inflammatory agent.




Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Anti-inflammatory effects of anethole in lipopolysaccharide-induced acute lung injury in mice
by PurumKanga1Ka YoungKima1Hui SuLeea1Sun SeekMinbGeun HeeSeol(PubMed)
(2) Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: e€ffect on NF-kB, AP-1, JNK, MAPKK and apoptosis by Gagan BN Chainy1,2, Sunil K Manna1,2, Madan M Chaturvedi1, and Bharat B Aggarwal by Oncogene (2000) 19, 2943 ± 2950 ã 2000 Macmillan Publishers Ltd All rights reserved 0950 ± 9232/00 $15.00

#Broccoli's #Sulforaphane #SFN Inhibits Urologic Cancer Cells by Inducing Apoptosis in Vitro, According to Studies

Kyle J. Norton

Urologic cancers are a class of medical conditions including prostate cancer is a condition in which the cells of the prostate have become cancerous, causing abnormal cell growth with the possibility of spreading to distant parts of the body.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

* Kidney cancer is a medical condition characterized by irregular cell growth in the tissue of the kidneys.

At the later stage, the cancerous cells may travel a distance way to infect other organs' tissues.
For example, if kidney cancer spreads to the lung is called kidney cancer with lung metastases.

* Bladder cancer
The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.

Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women.

* Cancer of the renal pelvis and ureter is a cancer of the renal pelvis on the top part of the ureter and the ureter which is a long tube that connects the kidney to the bladder

* Testicle cancer

Testicular Cancer is cancer that arises in the testicles (testes), located inside the scrotum. testicles form part of the male reproductive system, responding to the production and reproduction of male sex hormones and sperm.

* Cancer of the penis
Penis cancer is a type of irregular cell growth formed in the tissues of the penis.


* Urethra cancer
Urethral cancer is a type of medical condition caused by the growth of malignant cells in tissues of the urethra, the tube that carries urine from the bladder and out of the body.

The most common symptoms of urologic cancers are difficulty starting to urinate or difficulty holding urine back, weak urine stream or interruption of stream, painful urination, pelvic discomfort, bone pain, erectile dysfunction (ED), painful ejaculation, blood in the urine and blood in the semen.

The joint study led by the National Cancer Center, Goyang, Korea, wrote, "During 1999-2012 (In Korea), urological cancer occurred in 155,991 patients (Table 1). The most common cancer was prostate cancer (66,812 patients) followed by bladder cancer (41,549 patients), kidney cancer (36,836 patients), renal pelvis and ureter cancer (7,537 patients), testis cancer (2,439 patients), and penile cancer (818 patients)".

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

In finding a potential plant that processes anticarcinogenic activity, researchers examined the effects of sulforaphane (SF), a natural compound sulforaphane (SFN) anti-urologic cancer effects.

According to the tested analysis, the application of SFN shows a remarkable anti-tumor effect in vitro and in vivo without exerting toxicity.

Furthermore, based on available evidence from epidemiological, in vitro, preclinical, and early phase trials, SFN was not only available in standardized formulations but bioavailable- both systemically and in the bladder but also exerted a significant anti-bladder cancer through multiple mechanisms.

Additionally, similar to its effects on urological cancer, SFN induced cancer apoptosis without causing cytotoxicity.

Collectively, researchers said, "sulforaphane (SFN) represents a promising potential chemopreventative agent in bladder cancer".

Taken altogether, Broccoli processed abundant bioactive compound SFN, which may be considered a functional food for the prevention and treatment of urologic tumors, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The relevance of the natural HDAC inhibitor sulforaphane as a chemopreventive agent in urologic tumors by Juengel E1, Erb HHH2, Haferkamp A2, Rutz J3, Chun FK3, Blaheta RA. (PubMed)
(2) Current Trends in the Incidence and Survival Rate of Urological Cancers in Korea by Jae Young Joung, MD, Ph.D.,1 Jiwon Lim, MS,2 Chang-Mo Oh, MD, Ph.D.,2 Kyu-Won Jung, MS,2 Hyunsoon Cho, Ph.D.,2 Sung Han Kim, MD, Ph.D.,1 Ho Kyung Seo, MD, Ph.D.,1Weon Seo Park, MD, Ph.D.,1 Jinsoo Chung, MD, Ph.D.,1 Kang Hyun Lee, MD, Ph.D.,1 andYoung-Joo Won, Ph.D. (PMC)
(3) Sulforaphane for the chemoprevention of bladder cancer: molecular mechanism targeted approach by Andrew Leone,1 Gregory Diorio,1 Wade Sexton,1 Michael Schell,2 Mark Alexandrow,3Jed W. Fahey,4 and Nagi B. Kumar. (PubMed)