#Fennel's #Anethole Reduces the Onset of Acute Inflammation and Chronic Inflammatory Diseases, Scientists Find

Kyle J. Norton

Fennel may process a strong anti-inflammatory activity in reducing the risk of tissue injury and cell apoptosis, some scientists suggested.

Acute inflammation is a natural and systematic immune response to protect our body against the invasion of foreign bacteria and viruses by the initiated production of inflammatory cytokines to the site of infection.

However, overproduction of pro-inflammatory cytokines initiated by the immune system for a prolonged period of time may lead to cell damage and sometimes death of the healthy cells in the infectious site and nearby cells.

These complications can also cause improper healing for the forming of scars and damage to the tissue of the organ, affecting and limiting the organs' functioning, such as liver scars caused by hepatitis virus infection.

Badly enough, some proteins process the duo functions of pro and anti-inflammation. Under abnormal conditions, they can switch from their original action of anti-inflammatory cytokines to pro-inflammatory cytokines.

Furthermore, chronic inflammation occurred that lasts for months or years when the immune system responds to the site of infection failing to eliminate agents that cause acute inflammation.

An autoimmune disorder attacks normal healthy tissue, mistaking them for pathogens that can also cause chronic inflammatory disease.
Most cases of inflammation, are treated with NSAID's, or non-steroidal anti-inflammatory drugs. However, in some people intake of these medications can cause common and serious side effects, including gastrointestinal issues, such as pain, constipation, diarrhea, gas, nausea, and stomach ulcers, kidney problems, anemia,.... and swelling in the leg.

If you are presently taking anti-inflammatory medicine, please make sure that you discuss the adverse effects with your doctor.

Fennel (Foeniculum vulgare) is a plant species, belongings to Apiaceae (Umbelliferae), native to the Mediterranean.

The herbal medicine has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle and relieve PMS,...

According to a study of BALB/C mice were intraperitoneally administered anethole (62.5, 125, 250, or 500 mg/kg) 1 h before intratracheal treatment with LPS (1.5 mg/kg) and sacrificed after 4 h, researchers found that in anethole treatment group exerts a significant increase of numbers of mobile white blood cells macrophages and neutrophils, the first immune response to the infectious site.


Furthermore, the application of LPS also induced the production of inflammatory mediators such as matrix metalloproteinase 9 (MMP-9), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) all systematic inflammatory cytokines in response to cellular damage and tissue injury.

Moreover, LPS also exhibited overproduction of nitric oxide (NO) observed in bronchoalveolar lavage fluid in facilitated cellular cytotoxicity.


In the compared nontreatment group, the injection anethole group demonstrated a strong anti-inflammatory effect through decreased activities of proinflammatory factors without affecting the immune activity in protecting against infection.

Additional analysis also found that the treatment group reduced acute lung injury caused by the injection of LPS through its antioxidants and induced production of host natural antioxidants in the body tissue.

The inhibited LPS results according to were attributed to anethole effect in suppressing the activation of NF-κB in signaling the production of inflammatory cytokines by blocking the initiation of IκB-α degradation by inhibited TRAF2 in the induction of inflammation through TNF receptor superfamily members and NIK, a key signaling molecule of the noncanonical NF-κB.

Interestingly, further investigation of anethole as an inhibitor of TNF-induced NF-kB activation (an early response) as monitored by electrophoretic mobility shift assay, by suppression of IkBa phosphorylation and NF-kB reporter gene, researchers also indicated that

* Anethole also suppressed TNF-induced activation of the transcription factor AP-1 in regulated gene expression in response to a variety of stimuli, including LPS application.

*c-Jun N-terminal kinases (JNKs) with function in response to stress stimuli, such as cytokines,
And

* MAPKkinase in signals inflammatory response through transmitting information from a receptor on the surface of the cell to the DNA in the nucleus of the cell.


* Application of anethole also suppressed TNF-induced both lipid peroxidation and ROS generation, through the stimulated production of natural antioxidants in the host and itself, resulting in balancing the ratio of antioxidant and ROS expression.

The illustration and differentiation were elite by the experiment in the application of TNF (100 pM) with the cells pretreated for 240 and 120 min with anethole, NF-kB activation was almost completely inhibited.

However, the inhibition decreased gradually with decreased pre-incubation time.

Taken together, fennel and its bioactive anethole may be considered a functional food in reduced risk and treatment in acute and chronic inflammatory-related diseases through the properties like a pro-antioxidant and anti-inflammatory agent.




Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Anti-inflammatory effects of anethole in lipopolysaccharide-induced acute lung injury in mice
by PurumKanga1Ka YoungKima1Hui SuLeea1Sun SeekMinbGeun HeeSeol(PubMed)
(2) Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: e€ffect on NF-kB, AP-1, JNK, MAPKK and apoptosis by Gagan BN Chainy1,2, Sunil K Manna1,2, Madan M Chaturvedi1, and Bharat B Aggarwal by Oncogene (2000) 19, 2943 ± 2950 ã 2000 Macmillan Publishers Ltd All rights reserved 0950 ± 9232/00 $15.00

#Broccoli's #Sulforaphane #SFN Inhibits Urologic Cancer Cells by Inducing Apoptosis in Vitro, According to Studies

Kyle J. Norton

Urologic cancers are a class of medical conditions including prostate cancer is a condition in which the cells of the prostate have become cancerous, causing abnormal cell growth with the possibility of spreading to distant parts of the body.

Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

* Kidney cancer is a medical condition characterized by irregular cell growth in the tissue of the kidneys.

At the later stage, the cancerous cells may travel a distance way to infect other organs' tissues.
For example, if kidney cancer spreads to the lung is called kidney cancer with lung metastases.

* Bladder cancer
The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.

Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women.

* Cancer of the renal pelvis and ureter is a cancer of the renal pelvis on the top part of the ureter and the ureter which is a long tube that connects the kidney to the bladder

* Testicle cancer

Testicular Cancer is cancer that arises in the testicles (testes), located inside the scrotum. testicles form part of the male reproductive system, responding to the production and reproduction of male sex hormones and sperm.

* Cancer of the penis
Penis cancer is a type of irregular cell growth formed in the tissues of the penis.


* Urethra cancer
Urethral cancer is a type of medical condition caused by the growth of malignant cells in tissues of the urethra, the tube that carries urine from the bladder and out of the body.

The most common symptoms of urologic cancers are difficulty starting to urinate or difficulty holding urine back, weak urine stream or interruption of stream, painful urination, pelvic discomfort, bone pain, erectile dysfunction (ED), painful ejaculation, blood in the urine and blood in the semen.

The joint study led by the National Cancer Center, Goyang, Korea, wrote, "During 1999-2012 (In Korea), urological cancer occurred in 155,991 patients (Table 1). The most common cancer was prostate cancer (66,812 patients) followed by bladder cancer (41,549 patients), kidney cancer (36,836 patients), renal pelvis and ureter cancer (7,537 patients), testis cancer (2,439 patients), and penile cancer (818 patients)".

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

In finding a potential plant that processes anticarcinogenic activity, researchers examined the effects of sulforaphane (SF), a natural compound sulforaphane (SFN) anti-urologic cancer effects.

According to the tested analysis, the application of SFN shows a remarkable anti-tumor effect in vitro and in vivo without exerting toxicity.

Furthermore, based on available evidence from epidemiological, in vitro, preclinical, and early phase trials, SFN was not only available in standardized formulations but bioavailable- both systemically and in the bladder but also exerted a significant anti-bladder cancer through multiple mechanisms.

Additionally, similar to its effects on urological cancer, SFN induced cancer apoptosis without causing cytotoxicity.

Collectively, researchers said, "sulforaphane (SFN) represents a promising potential chemopreventative agent in bladder cancer".

Taken altogether, Broccoli processed abundant bioactive compound SFN, which may be considered a functional food for the prevention and treatment of urologic tumors, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The relevance of the natural HDAC inhibitor sulforaphane as a chemopreventive agent in urologic tumors by Juengel E1, Erb HHH2, Haferkamp A2, Rutz J3, Chun FK3, Blaheta RA. (PubMed)
(2) Current Trends in the Incidence and Survival Rate of Urological Cancers in Korea by Jae Young Joung, MD, Ph.D.,1 Jiwon Lim, MS,2 Chang-Mo Oh, MD, Ph.D.,2 Kyu-Won Jung, MS,2 Hyunsoon Cho, Ph.D.,2 Sung Han Kim, MD, Ph.D.,1 Ho Kyung Seo, MD, Ph.D.,1Weon Seo Park, MD, Ph.D.,1 Jinsoo Chung, MD, Ph.D.,1 Kang Hyun Lee, MD, Ph.D.,1 andYoung-Joo Won, Ph.D. (PMC)
(3) Sulforaphane for the chemoprevention of bladder cancer: molecular mechanism targeted approach by Andrew Leone,1 Gregory Diorio,1 Wade Sexton,1 Michael Schell,2 Mark Alexandrow,3Jed W. Fahey,4 and Nagi B. Kumar. (PubMed)

Kimchi and Amtak Baechu Cabbage Inhibit #PancreaticCancer by Inducing Cell Apoptosis and Cell Cycle Arrest, Researchers Say

Kyle J. Norton

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, the pancreas aids the digestive system to break down carbohydrates, proteins, and lipids.

Traditional Chinese medicine suggested that the pancreas is a vital organ responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our body.

Pancreatic cancer is a chronic condition characterized by cell growth irregularly in the tissues of the pancreas.

Most cases of pancreas cancer start in the cell on the surface of the inner lining tissue. However, as the cancer progress, the malignant cells of the pancreas, although unusual may travel a far distance away to infect other healthy tissue and organs.

The pancreas cancer was found to be the site of metastasis from renal cell cancer, lung, colon, and breast cancers.

According to statistics, every year, approximately, over 55,000 adults in the United States are diagnosed with pancreatic cancer, accounting for 3% of all cancers and 7% of all cancer deaths.

The survival rate of pancreatic cancer even if diagnosed early is very low compared to other types of cancer. The 5-year survival rate at stage IA pancreatic cancer is only14%.

The exact causes of pancreatic cancer are identified. However, epidemiological studies suggested that the increase in age, family history, race, gender, smoking, being obese or overweight and a medical condition such as diabetes is the most prevalent risk of the disease.

The genetic and acquired genetic mutation of p16 and TP53 and KRAS, BRAF, and DPC4 (SMAD4) were also found in patients with pancreatic cancer.

In finding a potential plant that processes anti-cancer property activity researchers investigated the effects of kimchi prepared using the standard Baechu cabbage and Amtak Baechu cabbage on hepatic cancer cells.

The study included 4 different kimchi samples prepared for this study which are t(1) the standard Baechu cabbage and dry salt treatment method (SK-D); (2) the Amtak Baechu cabbage and dry salt treatment method (AK-D); (3) the standard Baechu cabbage and brine solution treatment method (SK-B); and (4) the Amtak Baechu cabbage and brine solution treatment method (AK-B).


Based on the results of the analysis,
* The liver cancer cells showed a significant increase in cell growth inhibition when exposed to AK-D and AK-B compared with SK-D and SK-B (p < 0.05). At 2.0 mg/mL,

* AK-B and AK-D treatment exerted 2.0 times against the Capan-2 cells, compared with SK-B and SK-D.

* AK-D and AK-B treatment compared with SK-D and SK-B demonstrated a significant increase of tumor-suppressive p21 levels associated with apoptosis and cell cycle arrest.

* AK-B displayed higher ongoing cytotoxic effects compared with AK-D.


Based on the evidence, researchers said,. "Overall, these results indicate that kimchi made with Amtak Baechu cabbage and treated with brine solution (AK-B) had a superior anticancer potential against both types of cancer cells, with the effects being greater in pancreatic cancer cells compared with liver cancer cells".

Taken together, cabbage may be considered a functional food for the prevention and treatment of
pancreatic cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Beneficial Outcomes of Kimchi Prepared with Amtak Baechu Cabbage and Salting in Brine Solution: Anticancer Effects in Pancreatic and Hepatic Cancer Cells by Song GH1, Park ES1, Lee SM1, Park DB2, Park KY. (PubMed)

#Cucumber Enhances the Ratio of Gut Microbiota in the Gut Associated with the Improvement of Insulin Sensitivity, According to Studies

Kyle J. Norton

Insulin Resistance, a hallmark in patients with type II diabetes is the condition in which the cells in tissues that start to resist or ignore the signal of the hormone insulin.

In other words, the insulin produced by the body no longer can convert glucose to energy even with the presence of the hormone insulin, leading to high levels of glucose in the bloodstream.

According to the statistics provided by the CDC, approximately, 1 in 3 people in the United States have prediabetes, including half of those aged 60 and older.

People with insulin resistance have been found to increase the risk for prediabetes, type 2 diabetes and other serious health problems, such as cardiovascular disease and cancer.

Although researchers do not know the exact cause of insulin resistance, they do not certain risk factors such as genetic preposition, aging, and ethnicity are associated with the onset of the condition.

However, an unhealthy lifestyle that causes excess body weight, too much belly fat, smoking and lack of exercise are the most prevalent factors in the Western world.

Dr. Martin O. Weickert wrote, "Insulin resistance has been proposed as the strongest single predictor for the development of Type 2 Diabetes (T2DM). Chronic oversupply of energy from food, together with inadequate physical activity, has been recognized as the most relevant factor leading to overweight, abdominal adiposity, insulin resistance, and finally T2DM".

And, "Conversely, energy-reduced diets almost invariably facilitate weight loss and reduce abdominal fat mass and insulin resistance. However, sustained weight loss is generally difficult to achieve, and distinct metabolic characteristics in patients with T2DM further compromise success".

The findings strongly suggested that by maintaining a healthy lifestyle including a healthy diet and moderate exercise, insulin resistance is preventable.

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

In finding a potential compound for the treatment of insulin resistance, researchers investigated the effect of the effects of Cucumis melo L. (Cucumis) on obesity-induced insulin resistance (IR) in genetically leptin-deficient Lepob/Lepob mice.

According to the results of the tested assays, Cucumis showed significant activity in the improvement of IR in obese mice and inhibition of inflammation in adipose tissue and blood.

The efficacy of Cucumis against insulin resistance of the tested mice was also attributed to the enhancement of the ratio of gut microbiota in the gut-associated with the improvement of insulin sensitivity.

Based on the findings, researchers wrote in the final report, " administration of Cucumis improved IR by reducing inflammation, thereby changing the gut microbiota composition. Cucumis is thus a promising treatment for obesity-induced insulin resistance and the inflammatory state".

Lund University in the study of glycemic and insulinemic responses to fermentation products suggested that adding pickled cucumber to breakfast with a high-glycemic-index bread significantly lowered postprandial glycemia and insulinemia compared to no metabolic response of regular milk and fresh cucumber.

In other words, fermentation products such as Prickle play an essential role in reducing the risk of insulin resistance.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Taken altogether, fermented cucumber may be used for the treatment of insulin resistance, pending the confirmation of the larger sample size and multicenter human study.
Sources
(1) Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in Lepob/Lepob Mice by Lee D1, Yoo JH1, Lee BC. (PubMed)
(2) Inconsistency between glycemic and insulinemic responses to regular and fermented milk products by Ostman EM1, Liljeberg Elmståhl HG, Björck IM. (PubMed)
(3) Nutritional Modulation of Insulin Resistance by Martin O. Weickert. (PMC)

#Herbal #Butterbur #RootExtract Processes a Strong Free Radical Scavenging and Antioxidant Activity, Researchers Suggest

Kyle J. Norton

Herbal Butterbur may be the potential target to extract a single ingredient for the treatment of oxidative stress, some scientists suggested.
Oxidative stress is either caused by overexpression of free radicals compared to levels of antioxidants or suppression of the levels of antioxidant enzymes in the host body, compared to the expression of free radicals.

The imbalanced ratio of free radical and antioxidant enzymes produced by the host that counter the overexpression of free radicals has been found to facilitate the early onset of a number of chronic ailments, such as cancers.

Free radicals are naturally produced from daily normal essential metabolic processes in the human body. However, some external sources such as exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals can also increase the expression of free radicals in the body.

Free radicals are unstable molecules with the unpaired electron in the outer ring and ready to donate or steal an electron from another molecule, leading to the chain reaction until they are stopped by the presence of the antioxidants or their outer ring are paired.

Overexpression of free radical chain reactive in the human body has been known to induce oxidative stress, causing damage to the cells, proteins, and alternation of cell DNA. In this case, the application of an external source of antioxidants such as synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole may be helpful to restore the balance of these 2 types of molecule.

Hydroxyl radicals, superoxide anion radicals, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radicals, and peroxynitrite radicals are hight reactive and important free radicals associated with many chronic diseases.

Dr. V. Lobo, concerned about the overexpression of free radicals in the induction of, various human chronic illnesses conducted a study to examine the impacts of free radicals, antioxidants and functional foods in human health said in summary, "Free radicals damage contributes to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataract, and cancer. Antioxidants prevent free radical-induced tissue damage by preventing the formation of radicals, scavenging them, or by promoting their decomposition".

(More importantly)" Synthetic antioxidants are recently reported to be dangerous to human health. Thus the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years. In addition to endogenous antioxidant defense systems, consumption of dietary and plant-derived antioxidants appears to be a suitable alternative. Dietary and other components of plants form a major source of antioxidants".

Butterbur, found in wet, marshy, damp land, including wetlands, Riversides, forests, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to the Northern Hemisphere.

The herbal plant has been used in traditional medicine as a pain reliever in the digestive system, including the stomach, bile ducts, duodenum, etc.

The chemical constituents of Butterbur include Petioles, petasitene, and ethylene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.

In the finding of the natural ingredient from the botanical plants which process a significant antioxidant activity without inducing any side effects, researchers at the Second Military Medical University looked into a bioactive compound isolated from the herbal Butterbur.

Four novel bakkenolides - bakkenolide-Ia ( 1), bakkenolide-IIa ( 2), bakkenolide-IIIa ( 3) and bakkenolide-IVa ( 4) - were isolated from the extract of the rhizome of Petasites tricholobus.

All 4 compounds demonstrated neuroprotective activity by reversing the neuron's damage exposed to oxygen-glucose deprivation and oxidative insults.

The results of this efficacy were associated with the antioxidant properties of the 4 compounds in inhibiting the oxidative stress caused by the oxygen-glucose deprivation.

The finding indicated that herbal Butterbur not only processed a significant activity in protecting the brain cells against oxidative stress due to overexpression of free radicals but also promoted the production of antioxidant enzymes in the host tissue.

In hyphenated HPLC techniques used to identify the structures and antioxidant activities without prior purification of compounds, researchers found that herbal Butterbur process a number of bioactive compounds, including 5-caffeoylquinic acid (5-CQA), fukinolic acid (FA), 3,5-di-O-caffeoylquinic acid (3,5-DCQA) exert a strong antioxidant free radical scavenging activity.

The greatest radical scavenging capacity was found in the leaf (23.09% of total antioxidant capacity) and root (26.47%) extracts.

The relative radical scavenging portion of quercetin-3-O-(6″-acetyl)-β-glucopyranoside (QAG) was only 3.41% in the leaves and KAG did not show any radical scavenging activity.

These results firmly suggested that herbal Butterbur processes a significant antioxidant property. However, a single ingredient isolated from the herb may express different levels of antioxidants in a dose-depending manner.


Therefore, herbal Butterbur containing a high amount of antioxidants and bioactive compounds free radical scavengers may be considered a functional food for the promotion of antioxidant activity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities by Wang YL, Li RP, Guo ML, Zhang G, Zhang N, Ma YL.(PubMed)
(2) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)

#Pomace of #Tomato and Grape Shows a Significant Effect on #Hyperlipidemia Induced Neurons Damage in Diabetes, Scientists Say

Kyle J. Norton

Hyperlipidemia is a condition of abnormally high blood cholesterol in the bloodstream. The condition is also a member of the cluster of metabolic syndrome associated with the risk of type II diabetes and cardiovascular disease.
Cholesterol is a waxy substance with a double-edged sword. On one hand, cholesterol is essential for the body to build strong cellular membranes, production of steroid hormones, and vitamin D and aid digestion, on another hand, it also causes a number of diseases if overexpressed in the blood.

Cholesterol is either produced by the liver or by the intake of fat.

There are 2 types of cholesterol in the body, low-density lipoprotein (LDL, bad cholesterol) and high-density lipoprotein (good cholesterol).

Where high-density lipoprotein (HDL, good cholesterol) plays a critical role to return the cholesterol to the liver for future use. Low levels of high-density or high levels of lipoproteins may result in blood cholesterol accumulating in the blood, leading to high blood cholesterol.

The optimized ratio of LDL/ HDL is any number that is less than 4.

Dr. Joan Carles Escola`-Gil, the lead scientist in the evaluation of the Western diet risk of high blood cholesterol wrote, ". The HFHC diet caused a significant increase in plasma cholesterol, HDL cholesterol, and liver cholesterol and enhanced macrophage-derived [ 3 H]cholesterol flux to feces by 3- to 4-fold".

In other words, long-term intake of high-fat diet-induced hyperlipidemia.

Tomato is red, edible fruit, genus Solanum, belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a natural ingredient or whole food for the treatment of hyperlipidemia, researchers examined the effect of tomato and grape pomace on the cholesterol (0.3%) diet of male Wistar rats produced a dose-dependent effect.


During the experiment, researchers found that 5% pomace of either grape or combination showed no effects on reduced levels of hyperlipidemia.
However, 15% pomace of tomato and grape reduced serum cholesterol levels from 4.4 mmol/L to 2.5 mmol/L and 2.0 mmol/L respectively.

Interestingly, at the concentration of 15%, both tomato and grape pomace induced a redistribution of cholesterol in lipoproteins associated with an anti-atherogenic profile and reduced cholesterol concentration in very-low-density lipoprotein (VDL) (24% [tomato], 50% [grape]) and low-density lipoprotein (LDL) (3-fold, 3.6-fold).

Furthermore, both types of pomace enhanced the function of HDL in cholesterol transport by reducing the VLDL and LDL contribution.

Moreover, tomato and grape pomace reduced plasma levels of conjugated dienes involved in cholesterol oxidation in high levels by 30-50%

Additionally, injection also improved the antioxidant enzymes in the liver against lipid peroxidation.

In rats fed with hypercholesterolemic feed and treated with lycopene orally by gavage at the dose of 5, 25, 45, 65, 85, and 105, 125 mg/kg/bw-1/d-1, researchers found that injection of all doses of lycopene exerted a statistical significance in reduced the levels of cholesterol observed by inverse U shape at the 4 weeks of the experiment.

Furthermore, serum lycopene concentration was negatively correlated with the levels of serum TC, and LDL-C, particularly in the cerebral LDL-C.

Serum lycopene concentration was also found to have a positive correlation with the expression of Claudin-5 associated with brain microvascular endothelial cell proliferation, and migration. and the number of neurons in hippocampal CA1 and CA3.

In other words, serum lycopene showed a strong effect on the protection of neurons against hyperlipidemia in the brain that facilitates neuron damage.

Dr. Wang W, the lead scientist said, "These results suggested an inverse U-shape relation between dose and serum concentration of lycopene, and intermediate doses were most effective to protect cerebral vessels and neurons from being damaged by hyperlipidemia".


Taken altogether, tomatoes processed with high amounts of lycopene may be considered supplements for the prevention and treatment of hyperlipidemia, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) The dose-response effect of lycopene on cerebral vessel and neuron impairment induced by hyperlipidemia by Wang W, Yang W, Shen Z, Wen S, Hu M. (PubMed)
(2) Dietary tomato and grape pomace in rats: effect on lipids in serum and liver, and on antioxidant status by Bobek P. (PubMed)
(3) The Cholesterol Content of Western Diets Plays a Major Role in the Paradoxical Increase in High-Density Lipoprotein Cholesterol and Upregulates the Macrophage Reverse Cholesterol Transport Pathway by Joan Carles Escola`-Gil, Gemma Llaverias, Josep Julve, Matti Jauhiainen,Jesu´s Me´ndez-Gonza´lez, Francisco Blanco-Vaca

#Broccoli Enhances Several Xenobiotics Metabolizing Genes Associated with a Reduced Risk of #Cancer, Researchers Say

Kyle J. Norton

Xenobiotic metabolism is an action that protects the host against chemicals that affect normal metabolism.
Other common metabolisms may include
* Nutrient metabolism is a process that absorbs end products of food digestion such as monosaccharides, and also has been found to protect the gut mucosal barrier in preserving the ability to absorb nutrients.

* Drug metabolism is the process to alter chemicals of a drug that may cause harm to the body

The gut microbiota plays a critical role in regulating the systemic metabolism of the host including producing vitamins, synthesizing all essential and nonessential amino acids, and carrying out biotransformation of bile by interacting with other organs such as the intestine, liver, brain, and other organs through the host-microbiota and co-metabolism structure to form an ametabolic axis.

More precisely, under normal conditions, gut microbiota plays a critical role in overall health,
* Gut microbiota improves the absorption of dietary nutrients in the digestive system

* Gut microbiota protects the body against xenobiotics and drug toxicity by facilitating excretion.

* Gut microbiota also maintains the structural integrity of the gut mucosal barrier by enhancing the epithelial cells that protect the intestine against invasive pathogens and ensure the function of intestine in nutrient adsorption.

* Gut microbiota interacts with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

The imbalance of the ratio of gut microbiota may have a negative impact on human health and diseases.

Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anticarcinogenic activity, researchers examined the effects of sulforaphane (SF), the isothiocyanate derived from 4-methyl-sulphinyl butyl glucosinolate in broccoli induce-xenobiotic metabolizing.

The study included 16 subjects randomized, into a 3-phase crossover dietary trial of standard broccoli, high glucosinolate broccoli, and water.

According to the results of the trial, consumption of high glucosinolate broccoli showed a strong effect in the improvement of several xenobiotics metabolizing genes, including thioredoxin reductase, Aldo-keto reductases, and glutamate-cysteine ligase modifier subunit.

Furthermore, the affected genes also have been found to be improved after exposure to SF, in cell and animal models.

Compared to phytochemical sulforaphane (SF) and sulforaphane (SF), only 1 such gene was affected in the consumption of standard broccoli.

Taken together, the consequences of these results suggest that the broccoli processes the potential anticarcinogenic activity by upregulating the gene associated with xenobiotic metabolism, pending the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Consuming broccoli does not induce genes associated with xenobioticmetabolism and cell cycle control in human gastric mucosa by Gasper AV1, Traka M, Bacon JR, Smith JA, Taylor MA, Hawkey CJ, Barrett DA, Mithen RF. (PubMed)