#BetaSitosterol Protects the Pancreatic Islets and Inhibits Parameters Against the Risk of Type 2 #Diabetes, According to Studies

Kyle J. Norton

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice into the small intestine, the pancreas helps to break down carbohydrates, proteins, and lipids.

Traditional Chinese medicine views the pancreas, as a vital organ that is responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our body.
More precisely, the functions of the pancreas including the
* Production of enzymes digest fat, protein, and
carbohydrates.

* Production of juices combined with juices from the intestines to break down protein, carbohydrates, and fat, therefore, it plays an important role in maintaining good health.

* Production of insulin, which is important in regulating the amount of sugar or glucose in the blood.

Pancreatic islets are groups of hormones producing cells, including insulin and glucagon, that work together to maintain the proper level of sugar (glucose) in the blood.

Profound distortion of islet organization in the pancreas has been found to induce account abnormal secretory behavior of the glucagon-secreting A cells in insulin-dependent juvenile-onset diabetes.

Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

As of today, there is no cure for type 1 diabetes. Treatment is focusing on managing blood sugar levels with insulin injection, diet, and lifestyle changes.

According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.

About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

In finding a potential phytochemical for the prevention and treatment of infectious diseases, researchers elucidated the anti-diabetic effects of the extract of A. tenuifolia underground parts and β-sitosterol on rat pancreatic islets.

According to the results of the analysis,* The root extract of the plant and compound β-sitosterol isolated from the root extracts showed moderate α-amylase inhibitory activity.
* Furthermore, the herb root extract was able to increase the secretion of insulin in high concentrations (10 mg/mL) and improved the cell viability with no toxicity in all doses.

* The herbal extract could reduce the levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) associated with the onset of oxidative stress in orchestrating damage to the pancreatic islets.

* Moreover, the plant extract also significantly decreased the enzyme activity associated with pro-apoptotic expression by increasing the antioxidant capacity of the isolated cells.


In other words, all compounds found in the extract work synergistically to protect the pancreatic islets by inhibiting all parameters involved in pancreatic damage, particularly, the compound β-sitosterol

Taken altogether, beta-Sitosterol combined with other phytochemicals found in A. tenuifolia underground parts may be considered a supplement for the protection of pancreatic islets-induced diabetes, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Investigation of β-Sitosterol and Prangol Extracted from Achillea Tenoifolia Along with Whole Root Extract on Isolated Rat Pancreatic Islets by Rahimifard M1,2, Manayi A3,2, Baeeri M1, Gholami M4, Saeidnia S3, Abdollahi M. (PubMed)

#Herbal #Chamomile Modulates Enzymes Associated with Hepoprotective Effects, According to Studies

Kyle J. Norton

Chamomile is also known as camomile, the common name of many species of daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as an antispasmodic and anti-inflammatory constituent to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Ingredients

Guaianolides matricarin and achillin, acetoxyachillin and leucodin (= desacetoxymatricarin), corresponding C-11 stereoisomers(a),(Z)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (cis-GMCA), chlorogenic acid, (E)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (trans-GMCA), quercetagetin-7-O-β-d-glucopyranoside, luteolin-7-O-β-d-glucoside, apigenin-7-O-β-d-glucoside, chamaemeloside, apigenin 7-O-(6″-O-acetyl-β-d-glucopyranoside), apigenin] and one polyacetylene (tonghaosu)(b).


Chamomilla Recutita flavonoids (chamiloflan) showed to exhibit antioxidant and anti-inflammatory effects through the induced decrease of ceramide levels in the liver of old rats, according to the Kharkov Karazin National University(1). Flavonoids of German chamomile also exhibited the hepatoprotective effect, through affect sphingolipid metabolism and reducing the elevated ceramide level in the aged liver by normalized activities of key enzymes of sphingolipid turnover (neutral SMase and ceramidase) and ceramide contents in the damaged liver and liver cells, and stabilized the hepatocyte membranes. (2)


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References
(a) Guaianolides and volatile compounds in chamomile tea by Tschiggerl C1, Bucar F.(PubMed)
(b) Quantitative determination of phenolic compounds by UHPLC-UV-MS and use of partial least-square discriminant analysis to differentiate chemo-types of Chamomile/Chrysanthemum flower heads by Avula B1, Wang YH, Wang M, Avonto C, Zhao J, Smillie TJ, Rua D, Khan IA. (PubMed)
(1a) Anxiety disorder(Canadian mental health association)
References
(1) Effects of Chamomilla recutita flavonoids on age-related liver sphingolipid turnover in rats.
Babenko NA1, Shakhova EG.(PubMed)
(2) Effects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells by Babenko NA1, Shakhova EG.(PubMed)

#Total Phenolic Acids Found in #CarrotJuice Process Anti Hypertension Activity, According to Studies

Kyle J. Norton

Scientists may have found a common vegetable that has the potential to decrease high blood pressure quickly with no side effects, some studies suggested.
Hypertension is a condition characterized by persistent high blood pressure.

In the US approximately, one-third of the adults have hypertension, affecting over 77 million people in the country.

Additionally, among adults age 20 and older in the United States, in the non-Hispanic whites community, 33.4 percent of men and 30.7 percent of women are infected by the syndrome.

Hypertension is a slowly developed condition. Unless the syndrome has caused damage to the blood vessel, otherwise symptoms cannot be detected.

The cause of hypertension is a result of the hardening and thickening of the arteries (atherosclerosis), due to the slow progression of plaques accumulated on the wall of the arteries,

Some researchers suggested that hypertension is associated with the risk factors of a genetic preposition, longterm unhealthy diet, and lifestyle.


Dr. Butler MG, the lead scientist at the Kansas University Medical Center, in the study "Genetics of hypertension. Current status" wrote, " The heritable component of blood pressure has been documented in familial and twin studies suggesting that 30%-50% of the variance of blood pressure readings are attributable to genetic heritability and about 50% to environmental factors".

However, the genes that cause the onset of hypertension are unknown. Researchers suggested that
all genes involved with the renin-angiotensin-aldosterone system controlling blood pressure and salt-water homeostasis, proteins in hormonal regulation of blood pressure (enzymes and receptors of the minerals- and glucocorticoid pathways), and proteins coded by genes involved in the structure and/or regulation of vascular tone are susceptible to the cause of the condition.

Furthermore, according to the Journal of Human Hypertension in the article "Dietary and lifestyle factors in hypertension", the adoption of a healthy diet and lifestyle is important for preventing hypertension among individuals who are free of hypertension and has a central role in improved blood pressure control among patients with hypertension.6–8 For patients with hypertension, dietary and lifestyle interventions are commonly recommended as an initial strategy or as an adjunct to antihypertensive medication to control blood pressure and improve the cardiovascular risk profile.

And, regular physical activity and aerobic exercise of more than 5 h per week were associated with a lower risk of incident hypertension.18 and an anaerobic interval training program 2 days per week reduced levels of blood pressure in hypertensive and normotensive men.

These results suggested that if you follow a healthy diet, lifestyle, and regular physical activity, you can not have hypertension regardless of the genetic preposition.

Unmanaged hypertension can lead to a heart attack, stroke, and other complications such as hypertensive retinopathy. chronic kidney disease.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asia and Europe.

In the study to reaffirm the effects of Daucus carota (carrot) for the treatment of hypertension in traditional medicine, researchers at The Aga Khan University Medical College conducted an experiment to test the antihypertensive activity of two coumarin glycosides DC-2 and DC-3 isolated from the vegetable.

In normotensive anesthetized rats, intravenous administration of the compounds lowers the arterial blood pressure in a dose-dependent of 1-10 mg/kg.

In vitro, both compounds caused a dose-dependent (10-200 microg/ml) inhibitory effect on spontaneously beating guinea pig atria as well as on the K+ -induced contractions of rabbit aorta at similar concentrations.

The findings suggested that carrots may process antihypertensive properties by blocking the calcium channels which can induce the membrane excitation of vascular muscle in contributing to hypertension.

In the concerns of obesity associated with chronic, low-grade inflammation predisposing the individual to hypertension and impaired blood glucose homeostasis, scientists launched an investigation to examine whether phenolic acids from purple carrots are effective at reversing inflammation and metabolic alterations through the mean of the acid in the Mediterranean diet

After the final assessment, researchers found that

* The mean intake of total phenolic acids of 362.6 mg/day is associated with a reduced risk of hypertension.

* When taking into account individual subclasses of phenolic acids, only hydroxyphenyl acetic acid was inversely associated with hypertension.

The findings suggest that dietary phenolic acids may be inversely associated with hypertension, irrespective of their dietary source.

Taken together, purple carrots with abundant phenolic acids may be considered a natural functional food for the prevention and treatment of hypertension.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Hypotensive action of coumarin glycosides from Daucus carota by Gilani AH1, Shaheen E, Saeed SA, Bibi S, Irfanullah, Sadiq M, Faizi S(PubMed)
(2) A randomized, double-blind, placebo-controlled trial of the effect of dried purple carrot on body mass, lipids, blood pressure, body composition, and inflammatory markers in overweight and obese adults: the QUENCH trial by Wright OR1, Netzel GA, Sakzewski AR. (PubMed)

#Tocopherols Combined with #Pentoxifylline Inhibit #Osteoradionecrosis (ORN) Induced by Radiotherapy in Head and Neck Cancer Patients

Kyle J. Norton

Head and neck cancer is a group of cancers found in the mouth, throat, larynx, sinuses, or salivary glands.
Most cases of head and neck cancer, at the early stage, start with the cell growth irregularly and disorderly on the surface of the inner lining of the head and neck.

At the advanced stage, patients may experience symptoms of a lump in the nose, neck, or throat, with or without pain, a persistent sore throat that does not heal, trouble swallowing (dysphagia), and frequent and persistent coughing.

At this stage, cancer cells may travel a distance away from the original site to infect other healthy tissue and organs.

The exact causes of head and neck cancer are unknown. However, certain prevalent risk factors such as prolonged sun exposure, infection by the Human papillomavirus (HPV) and Epstein-Barr virus (EBV), poor oral and dental hygiene and occupational inhalants, long-term marijuana, and tobacco use and involuntary smoking are associated with the onset of head and neck cancer.

Dr. Kazuhiro Kobayashi in the investigation of the risk of HPV on head and neck cancer (HNC) wrote, " Infection with high-risk human papillomaviruses (HPVs) has recently been implicated in the pathogenesis of HNSCCs. It is now widely accepted that high-risk HPV is a cause of almost all cervical cancers as well as some forms of HNSCCs. HPV-related HNSCCs are increasing".

Osteoradionecrosis is a condition associated with bone death due to exposure to radiation or radiation treatment.

The death of bone cells is a result of radiation induce-damage to the blood vessel that supplies the nutrients to the bone.

Osteoradionecrosis is a rare side effect occurred sometime after radiation therapy has ended. The complication usually occurs in the lower jaw or mandible.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

In finding a potential phytochemical for the prevention and treatment of cancer, researchers examined the effect of the modalities of the combination therapy of pentoxifylline and tocopherol in Vitamin E (PVe) against osteoradionecrosis (ORN) of the jaw induced by radiotherapy in head and neck cancer patients.

The study included 110 patients in this retrospective study, which had radiotherapy for cancer of the head and neck with a total of 450 dental extractions after radiotherapy.

According to the tested results of patients who had taken PVe for a mean of 12 (24) weeks preoperatively and 14 (18) weeks postoperatively, PVe treatment in external beam therapy was given in 92.72% of the patients, and 7.27% and 40% of the patients received intensity-modulated radiotherapy combination of chemotherapy and intensity-modulated radiotherapy, induced the development of ORN only in 2 patients.

Compared to untreated patients were lower than that normally associated with dental extractions in irradiated patients.

Based on the findings, researchers said, "In patients undergoing dental extractions, after receiving radiotherapy of head and neck region, combination therapy of pentoxifylline and tocopherol are sufficiently effective".

Taken together, tocopherols used in combination with other medications may reduce the risk of radiotherapy side effects in the development of osteoradionecrosis (ORN) of the jaw in head and neck cancer patients. pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
)
Sources
(1) Prophylactic Use of Pentoxifylline and Tocopherol in Patients Undergoing Dental Extractions Following Radiotherapy for Head and Neck Cancer by Aggarwal K1, Goutam M2, Singh M2, Kharat N3, Singh V4, Vyas S5, Singh HP. (PubMed)
(2) A Review of HPV-Related Head and Neck Cancer by Kazuhiro Kobayashi,1 Kenji Hisamatsu,1 Natsuko Suzuki,1 Akira Hara,1,2 Hiroyuki Tomita,2,* and Katsuhiko Miyazaki. (PMC)

#Flavonoids and #Phenolic Found in #Artichoke #Leaf #Extract Modulate the Genotoxicity Against Carcinogens, According to Studies

Kyle J. Norton

Substances such as radionuclides, or radiation which can cause the onset of cancer with or without changing the cell DNA are considered carcinogens.

In contrast to general belief, unhealthy lifestyle, long-term exposure to sunlight, certain medical treatments such as radiation, and medications such as immune-suppressive drugs, chemical exposure may also be considered carcinogens.

However, most people exposed to the substances have never developed cancer.

According to the World Health Organization (WHO), substances that cause cancer in humans can be classified into 5 categories.
Group 1: Carcinogenic to humans
Group 2A: Probably carcinogenic to humans
Group 2B: Possibly carcinogenic to humans
Group 3: Unclassifiable as to carcinogenicity in humans
Group 4: Probably not carcinogenic to humans

The most dangerous carcinogens are placed in group 1. Therefore, if you are handling any of the substances in group 1 (the list can be found here), please make sure you protect yourself according to the standard guidelines.


Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas, bloating, etc.

Researchers on the finding of natural therapeutics which block carcinogens in the induction of cancer investigated the antigenotoxic and antioxidant effects of the extract of artichoke Cynara cardunculus L. (CCE).

In the Saccharomyces cerevisiae mutagenicity/antimutagenicity assay, CCE significantly reduced the frequency of 4-nitroquinoline-N-oxide-induced genetics alternation in the diploid Saccharomyces cerevisiae tester strain D7.

In the simultaneous toxicity and clastogenicity/anticlastogenic assay, CCE exerted an anticlastogenic effect against N-nitroso-N'-methyl urea-induced clastogenicity in the plant species.

According to the free radical scavenging assay, CCE also exhibited considerable antioxidant activity against carcinogens.

In order to reveal more information about artichoke, anticarcinogenic activity researchers examined the genotoxicity of C. scolymus L. leaf extract (LE) and the ability to modulate the genetic toxicity of the alkylating agent ethyl methanesulfonate (EMS), using the comet assay on Chinese hamster ovary cells.

LE demonstrated strong anti-genotoxicity after 1- and 24-h treatments by 4 different doses: 0.62, 1.25, 2.5, and 5.0 mg/mL, according to the results from pretreatment, simultaneous treatment, and post-treatment.

All doses also protect the cell against DNA damage induced by the alkylating agent ethyl methanesulfonate (EMS), after exposure for 1 and 24 h.

Interestingly, the lowest dose of LE was more protective than higher concentrations.

The genotoxic and antigenotoxic effects were attributed to the bioactive flavonoids and phenolic compounds found abundantly in artichoke.

Taken together, artichoke-processed bioactive compound flavonoids and phenolic may be considered a functional remedy for the prevention and treatment of carcinogenic toxicity, with no side effects, pending the validation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Antigenotoxic effect of extract from Cynara cardunculus L. by Miadokova E1, Nadova S, Vlckova V, Duhova V, Kopaskova M, Cipak L, Rauko P, Mucaji P, Grancai D. (PubMed)
(2) Artichoke induces genetic toxicity and decreases ethyl methanesulfonate-related DNA damage in Chinese hamster ovary cells by Jacociunas LV1, de Andrade HH, Lehmann M, de Abreu BR, Ferraz Ade B, da Silva J, Dihl RR. (PubMed)
(3) Known and Probable Human Carcinogens by the American Cancer Society

The Effects of #Capsicum Found in #Herbal #Cayenne On High Blood Pressure, According to Studies

Kyle J. Norton

Herbal cayenne processed a significant amount of bioactive compound Capsicum may have a positive and profound effect on normalizing the levels of blood pressure, according to studies.

Hypertension is a medical condition of abnormally high blood pressure, one of the members of the cluster of conditions associated with heart disease and stroke.

Depending on the reading, some researchers suggested if you are in stage one of high blood pressure, your risk of cardiovascular disease is increased by 10% over the next 10 years.

According to the statistics, in the US, approximately 75 million people, or 1 in 3 U.S. adults have high blood pressure. High blood pressure can be modified by change of lifestyle.

The most common risk factors for high blood pressure are a poor diet with high in salt and potassium and low in vitamin D, being physically inactive, excessive alcohol drinking, use of Non-steroidal Anti-inflammatory Drugs (NSAIDs), and aging.

However, not all people with some of the above conditions will develop high blood pressure.

Treatment of stage 1 and 2 hypertension include daily intake of diuretics which lower high blood pressure by reducing sodium and fluid through increased urinary secretion and Bumetanide (Bumex) Chlorthalidone (Hygroton) or Chlorothiazide (Diuril).

Some patients may experience side effects such as a cough, diarrhea or constipation, dizziness or nervousness, tiredness, weak, and nausea or vomiting.

In a serious case, high blood pressure medication may induce erectile dysfunction. If you are taking high blood pressure medications, please make sure you have discussed the side effects with your doctor.

Some researchers in concerned about widespread hypertension in the Western world suggested that the condition may correlate to the promotion of the Western diet over the past few decades.

Dr. Adriana Monge and colleagues examined the Western and Modern Mexican diet pattern and risk of high blood pressure, wrote, "The multivariable-adjusted odds of hypertension in the highest quartile of the Western (W) pattern were 24% higher than the odds for individuals in the lowest quartile"

And, "women in the highest quartile of the MM pattern had 15% higher odds than women in the lowest quartile. The Fruits & Vegetables (FV) pattern was not significantly associated with hypertension".

These results clearly indicated a strong connection between the Western diet pattern in the increased risk of hypertension compared to the lower risk of fruits and vegetable groups.


Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to subtropical and tropical regions.

The pepper has been used in traditional medicine to increases metabolism, enhance the circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

The chemical constituents of Cayenne include capsaicin, capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.

Epidemiological studies linking cayenne in reducing hypertension have not been conclusive, the mechanism of this effect is still a mystery.

Researchers on finding herbal medicine for the treatment of hypertension with no side effects examined the traditionally used medicinal plants against key enzymes relevant for hyperglycemia and hypertension.

Compared to other herbal plants, pepper (Capsicum) inhibited significantly the hypertension-relevant angiotensin I-converting enzyme (ACE).


All evaluated pepper (Capsicum) genus exhibited both anti-hyperglycemia and anti-hypertension potential.

The anti-high blood pressure of cayenne probably is associated with the major compound capsaicin, chlorogenic acid, and hydroxycinnamic acid derivatives.

However, in the pig study, application capsaicin isolated from the cayenne showed a significantly increased mean arterial blood pressure compared with controls, and a decrease in CGRP synthesis and release contributes to the elevated blood pressure.

Also, there are 2 cases reported of an arterial hypertensive crisis in a patient with large ingestion of peppers and chili peppers the day before and a 19-year-old Italian man with abundant ingestion of peppers and of chili peppers the preceding day.


Additionally, overdoses of cayenne not only induced arterial hypertensive crisis but also acute myocardial infarction with high levels of thyroid-stimulating hormone.


The findings strongly suggested cayenne processed an antihypertensive and hypertensive effect in a dose-dependent manner.

These dual mechanisms presented in Cayenne may not be explained by conventional medicine. However, traditional Chinese medicine stated cayenne, yang in nature, promotes the Qi movement of blood. In a healthy individual, the smooth movement of qi reduces unnecessary blood pressure in blood transportation. On the other hand, if the movement of qi is blocked due to the presence of a high amount of cholesterol that narrows the blood vessel, it induces higher blood pressure.

The traditional Chinese medicine continued, injection of a high amount of cayenne pepper can cause constriction of blood vessels, leading to narrowing blood flow and risk of hypertension

Taken together, there is no doubt that cayenne may be considered a functional remedy for the prevention and treatment of hypertension, but the amount of intake should only be prescribed by related field specialists.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America by Ranilla LG1, Kwon YI, Apostolidis E, Shetty K.(PubMed)
(2) Capsaicin and arterial hypertensive crisis by Patanè S, Marte F, La Rosa FC, La Rocca R.(PubMed)
(3) Capsaicin, arterial hypertensive crisis and acute myocardial infarction associated with high levels of thyroid stimulating hormone by Patanè S, Marte F, Di Bella G, Cerrito M, Coglitore S.(PubMed)
(4) Western and Modern Mexican dietary patterns are directly associated with incident hypertension in Mexican women: a prospective follow-up study by Adriana Monge,1,2 Martín Lajous,1,4 Eduardo Ortiz-Panozo,1 Beatriz L. Rodríguez,2,3José Juan Góngora,2 and Ruy López-Ridaura. (PMC)

#Ethanol #Extract from Leaves From #Herbal #Artichoke Inhibits Enzymes Agaisnt the Risk of #Diabetes through Its Antioxidant Activity, Scientists Say

Kyle J. Norton

Diabetes is a medical condition caused by not enough insulin entering the bloodstream as a result of the loss of beta cells in the pancreas or insulin receptor sites clogged by plaques that are responsible for the production of insulin.

The insulin receptor sites processed a function that binds the insulin and passes the message into the cell, leading to the transformation of glucose from the blood to energy.

The hallmark of diabetes is insulin resistance. The condition has been found to increase the risk of cardiovascular disease even without the presence of diabetes.

The exact causes of insulin resistance are unknown. However, some researchers suggested that genetic preposition and lifestyle are major risk factors that cause the onset of the syndrome.

According to the statistics, in the US, between 60 to 70 million individuals are affected by insulin resistance. More than 40% of individuals older than 50 years may be at risk of insulin resistance.

Some researchers suggested that the widespread insulin resistance in the US may be a result of the promotion of the Western diet over the past few decades.

Dr. Merat S, in the examination of the Western-type diets in the risk of insulin resistance, said, "the Western diets commonly used in LDLR-/- mice may not only induce atherosclerosis but also IR, potentially complicating the interpretation of results".


Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas, and bloating, etc.

Researchers on the finding of natural therapeutics for the treatment of diabetes investigated the artichoke leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats.

The study included 40 male Wistar rats induced diabetes with a single dose intraperitoneal injection (i.p.) of alloxan (150 mg/kg body weight (b.w.)) randomly assigned to orally and daily administrated of ethanol extract from C. scolymus at two doses (200-400 mg/kg, b.w) or (12 mg/kg, b.w).

According to the tested assays, the ethanol extract from leaves of C. scolymus showed the highest antioxidant activity and endowed the powerful inhibition in vitro of α-amylase activity with IC50=72,22 ug/uL.

In vivo, the ethanol extract from the leaves of C. scolymus (200-400 mg/kg) decreased significantly the levels of α-amylase enzymes involved in the digestion of carbohydrates in the serum of diabetic rats.

Furthermore, the administration of ethanol extract improved the anti-oxidative activity demonstrated by the increase of CAT, SOD, and GSH activities in the liver, kidney, and pancreas of diabetic rats.

Compared to diabetic rats, the ethanol extract from leaves of C. scolymus also decreased blood glucose rate, plasma total cholesterol (T-Ch) and triglyceride (TG), and low-density lipoproteins (LDL-C) after 28 days of treatment.

Researchers after taking into account other factors said, "These observed strongly suggest that ethanol extract from the leaves of C. scolymus has anti-hyperglycemic properties, at least partly mediated by antioxidant and hypolipidemic effects".

In order to reveal additional information about artichoke antidiabetic properties, researchers in the joint study led by Hallym University examined the Jerusalem artichoke inhibitory activity against α-glucosidase and fasting serum glucose levels.

In a non-insulin-dependent diabetes mellitus animal model (C57BIKsJ db/db) selected for the study, water extract of PJA fermented by L. plantarum, and two strains of Bacillus subtilis injection showed the highest α-glucosidase inhibitory activity in vitro, compared to original Jerusalem artichoke (PJA).

PJA fermentation group significantly lower blood glucose concentration than the control.

At the end of 7 weeks, PJA fermentation group also induced higher levels of serum insulin and HDL cholesterol levels and lower the concentrations of triglycerides, non-esterified fatty acids, and total cholesterol.

Additionally, the intestinal α-glucosidase activity was partially inhibited by the PJA fermentation injection.

Taken together, artichoke may be considered a functional remedy for the prevention and treatment of diabetes with no side effects, pending the validation of a larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats by Ben Salem M1, Ben Abdallah Kolsi R2, Dhouibi R1, Ksouda K1, Charfi S3, Yaich M4, Hammami S1, Sahnoun Z1, Zeghal KM1, Jamoussi K4, Affes H. (PubMed)
(2) Fermentation of purple Jerusalem artichoke extract to improve the α-glucosidase inhibitory effect in vitro and ameliorate blood glucose in db/db mice by Wang Z1, Hwang SH1, Lee SY2, Lim SS. (PubMed)