#Cucumber's Cucurbitacin B Inhibits Genes Associated with the Promotion of #HeartHealth, According to Studies

Kyle J. Norton

The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels to nourish the body tissues and organs.

Most cases of heart dysfunction are associated with the reduced function of the heart muscle, leading to reduce blood flow that facilitates heart failure and the backup of blood into the lungs or rest of the body.

According to the statistics provided by the US government, heart disease is a leading cause of death in the US. Over 600,000 died of heart disease, every year including 370,000 people died of coronary heart disease (CHD), accounting for 1 in 4 deaths.

The most common symptoms of heart disease are poor appetite, weight loss, shortness of breath, sudden collapse, blood clots and stunted growth found in children.

If you have experienced some of the aforementioned symptoms, please check with your doctor to rule the risk of heart disease.

By following a healthy dietary intake, physical activity, weight management, smoking cessation, blood pressure control, and lipid management, most cases of heart disease are preventable.

Dr. Melanie Warziski Turk, in the evaluation of the risk of heart disease in women, wrote, "Because heart disease is frequently preventable, increasing awareness of personal risk and preventative measures is a key element of healthcare for women".

And, "Nurse clinicians can evaluate, educate, and counsel women regarding their risk for this pervasive disease and promote behavior changes that will decrease that risk. Research evidence supports that lifestyle behaviors are the cornerstone of heart disease prevention".

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound for the improvement of heart health, researchers investigated the therapeutic impact of cucurbitacin I on the heart.

According to the tested assay, phenylephrine (PE)-induced muscle cell enlargement and cardiac hypertrophy was inhibited by the pretreatment of the cardiomyocytes with cucurbitacin I.


Furthermore, cucurbitacin I protect the heart connective tissues against the onset of cardiac fibrosis.

More importantly, cucurbitacin I also significantly expressed the heart muscle protective effect by inhibiting the factors associated with the increase of blood pressure.

In order to reveal more information about cucumber anti-cardiac hypertrophy, a leading cause of heart failure, researchers evaluated cucurbitacin B anti-hypertrophy and anti-fibrosis potential both in vitro and in vivo.

Selected mice induced cardiac hypertrophy after 1 week of surgery, were given cucurbitacin B treatment for 4 weeks.

At the end of the experiment, cucurbitacin B demonstrated strong anti-hypertrophy and anti-fibrosis ability evidenced by decreased heart weight, myocardial cell cross-sectional area, and interstitial fibrosis.

Additionally, the levels of heart systolic and diastolic abnormalities induced by the surgery were also moralized by the application of cucurbitacin B.

Furthermore, gene expressions induced hypertrophic and fibrotic markers, and reserved microvascular density in pressure overload-induced hypertrophic mice were also normalized by the injection of cucurbitacin B.

Taken together, cucumber and its bioactive compound cucurbitacin I and B (CuB) may be used for the improvement of heart health, pending the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings by Moon Hee Jeong,# 1 Shang-Jin Kim,# 2 Hara Kang, 3 Kye Won Park, 4 Woo Jin Park, 1Seung Yul Yang, 5 and Dong Kwon Yang. (PMC)
(2) Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy by Yang Xiao, Zheng Yang, Qing-Qing Wu, and Xiao-Han Jiang. (Research Gate)
(3) Cardiac Health: Primary Prevention of Heart Disease in Women by Melanie Warziski Turk, Ph.D., MSN, RN, a Patricia K. Tuite, MSN, RN,b and Lora E. Burke, Ph.D., MPH, FAHA, FAAN. (PMC)

#Lycopene Found in Tomato Improves Pancreas function in Diabetics in Vivo, According to Studies

Kyle J. Norton

Diabetes occurs when cells in the pancreas die off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice to the small intestine, the pancreas helps to break down carbohydrates, proteins, and lipids. Traditional Chinese medicine views the pancreas as a vital organ that is responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our bodies.

The effects of the pancreas on diabetes
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, is the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

As of today, there is no cure for type 1 diabetes. Treatment is focusing on managing blood sugar levels with insulin injection, diet, and lifestyle change.

* Type 2 diabetes, the most common form of acquired diabetes in adulthood is a chronic condition that affects the body metabolized glucose. In other words, most cases of type 2 diabetes are results of insulin receptors clogged-up by fat and cholesterol, leading to resist the effects of the hormone insulin that regulates the movement of sugar into your cells.


* Gestational diabetes is a form of diabetes that can occur during pregnancy, affecting between 3% and 20% of pregnant women.

Women with gestational diabetes are at an increased risk of type 2 diabetes in later life.

According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.

About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.

Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of diabetes, researchers examined the role of lycopene (L) on the changes occurring in estrogen receptor (ER) α-positive cells and oxidative stress markers in the pancreas of experimentally induced adult diabetic rats.

According to the results from a single dose of 50 mg/kg streptozotocin (STZ), t5o induce diabetes in rats, divided into four groups: Control + corn oil, control + lycopene, diabetic + corn oil, and diabetic + lycopene.

Diabetic groups showed a higher number of proliferating Ki-67 positive cells without affecting apoptotic cell number compared to control.

In lycopene treatment groups
* Lycopene first time treated group showed with the presence of ER α-positive cells around the islets did not have any effect on any of the parameters aforementioned in diabetic groups.

* Increasing the dose and/or the duration of lycopene demonstrated the antioxidant effects on the pancreas of diabetic rats observed by lowering oxidative stress

Taken together, long-term lycopene intake may be considered supplements for the improvement of pancreas function in the diabetics, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Changes in the Pancreas in Experimental Diabetes and the Effect of Lycopene on These Changes: Proliferating, Apoptotic, and Estrogen Receptor α Positive Cells by Sandikci M1, Karagenc L1, Yildiz M. (PubMed)
(2) Changes in rat ovary with experimentally induced diabetes and the effects of lycopene on those changes in Yildiz M1, Sandikci M. (PubMed)

#Herbal #Cleaver Enhances the Body's Antioxidant Enzymes Against Overexpression of Free Radicals, Researchers Show

Kyle J. Norton

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals in the induction of oxidative stress.
In other words, antioxidants inhibited the onset of free radicals before they can cause a chain reaction in facilitating protein, lipid, and cell damage.

Antioxidants can either be produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

However, in people with a weakened immune system, intake of dietary sources of antioxidants may be necessary.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily donate or steal an electron from other molecules, leading to the chain of domino effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.

Oxidative stress is a result of an imbalance in the ratio of free radicals and antioxidants in the body.

Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as a mild diuretic and blood and lymphatic cleanser to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stones, etc.

In finding a potential compound for the treatment of diseases associated with oxidative stress, researchers compared the phenolic content and the antioxidant activity of Anthyllis vulneraria L., Fuchsia sp., Galium mollugo L., and Veronica beccabunga L.

According to the chemical analysis, the Galium mollugo polyphenol tannin, and flavonoid contents are 1.77 ± 0.05, 0.49 ± 0.04, and 0.16 ± 0.06 g/100 g dry weight) compared to those of Fuchsia species of 7.40 ± 0.8, 5.62 ± 0.7 and 0.72 ± 0.1 g/100 g dry weight and Anthyllis vulneraria (0.68 ± 0.02, 0.17 ± 0.03 and 0.45 ± 0.01 g/100 g dry weight., respectively.

More precisely, herbal cleaver(Galium aparine) showed a higher total polyphenol, tannin, and flavonoid contents than A. vulneraria but lower, compared to those of Fuchsia sp.

In other words, all antioxidant compounds found in herbal cleaver(Galium aparine) work together to exert anti-free radical activity in the stimulation of the onset of oxidative stress.

Taken together, Cleaver processed an antioxidant activity against the risk of oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional  Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Examination of secondary metabolites and antioxidant capacity of Anthyllis vulneraria, Fuchsia sp., Galium mollugo and Veronica beccabunga by Csepregi R1,2, Bencsik T1, Papp N. (PubMed).

#Fennel #Equeous Extract Protectrs the Gastric Function Against the Risk of Infantile Colic and Colitis, Researchers Say

Kyle J. Norton

Fennel may have a profound and positive effect on the reduced risk of infantile colic, some scientists suggest.

Infantile colic is a reaction of the infant if episodes of crying for more than three hours a day, for more than three days a week, for three weeks in an otherwise healthy child. The condition has a strong impact on the psychological, emotional, and physical burden to parents.

Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)

In a randomized, double-blind, placebo-controlled trial to investigate the effectiveness and side effects of phytotherapeutic agents with Matricariae recutita, Foeniculum vulgare, and Melissa officinalis in the treatment of infantile colic in a total of 93 breastfed colicky infants conducted by the John Wiley & Sons, Ltd, after a 3 day observation period, the infants randomly assigned to groups treated with the phytotherapeutic agent (PA) and the group received placebo twice a day for 1 week, researchers found that crying time in the group received PA was reduced substantially in 85.4% of subjects in compared to 48.9% subjects in placebo group against a baseline.

The PA treatment group exerted no side effects during the period of the experiment.

Based on the result, researchers suggested that PA demonstrated a significant activity within one week of application in infantile colic.


Furthermore, the St. Petersburg Medical Academy of Postdoctoral Education in concerned with the side effects of 5% of infants treated with dicyclomine hydrochloride, the only pharmacological treatment for infantile colic, with substantial side effects, including death, conducted a randomized placebo-controlled trial of 125 infants, 2 to 12 weeks of age from 2 large multi-specialty clinics by assigning them to either group treated with fennel or placebo, indicated that fennel treatment group improves the crying time episodes and frequency significantly in compared to the placebo group.

According to the Wessel assay, infantile colic was reduced by 65% (40/62) in the treatment group in comparison to only 23.7% (14/59) in placebo.


Further analysis also found that the application of fennel induced a risk reduction of 41% in comparison to placebo without causing any side effects.

Although the causes of infantile colic are unknown, some researchers suggested that the results of fennel in treatment of infantile colic may be attributed to its efficacy in the hypothetical conditions catalyzed by
*Abnormal gastrointestinal function caused by imbalanced of the bacterial ratio

According to the literature reported by the Swansea University, the application of fennel essential oil has a sustainable effect in inhibiting E. coli growth, observed by disc diffusion assays and in liquid culture.

These results were illustrated by the effect of an aqueous extract of the aerial part and an aqueous extract of seed samples of fennel.

Fennel inhibited the overgrowth of Agrobacterium radiobacter pv. tumefacient, Erwinia carotovora, Pseudomonas fluorescens, andPseudomonas glycinea, Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Pseudomona aeruginosa, Salmonella typhi, Salmonella typhimurium, Shigella flexneri, and Bacillus cereus in maintenance integrity of digestive function.

Further differentiation also suggested that fennel has a strong impact in protecting gastric damage through significantly increased nitrite, nitrate, ascorbic acid, retinol, and beta-carotene levels.

Dr. Shamkant B. Badgujar, the lead author, in the differentiation of fennel, in regard to the gastrointestinal effect, said, "Foeniculum vulgare is indicated in the treatment of spastic gastrointestinal disturbances, in some forms of chronic colitis (which resist other treatments), in dyspepsias from gastrointestinal atony, in dyspepsias with the sensation of heaviness in the stomach, and so forth. The addition of fennel to preparations containing anthraquinone components reduces the occurrence of abdominal pain often associated with this type of laxative"

* In Psychological aspect of mother such as mother’s depression, anxiety and distress during pregnancy in induction of infantile colic, although there is no direct literature to confirm the efficacy of fennel in treating syndromes of this group of women, in the study of psychological symptoms in women with premenstrual syndrome, application of fennel seed was associated in decreased depression and anxiety.

Also, in stress-induced maternal anxiety and depression, the application of fennel extract (50, 100, and 200 mg/kg body weight) showed a significant improvement of urinary levels of vanillyl mandelic acid(VMA) and ascorbic acid excretion levels in the measurement of potentially psychological stress in the fennel treatment group in compared to the normal group.

These results indicated that the extract of the entire plant of F. Vulgare pay has a potential effect by acting as an anti-stress agent in reducing depression and anxiety during maternity.


* In the food allergic aspect, although there are no direct studies on the expression of a fennel-improved immune response against food allergy,.

Some researchers postulated that anethole, a bioactive compound from fennel inhibited food allergy probably through enhancing the immune system's food hypersensitivity response by modulating the expression of Foxp3+ in regulated the development and function T cells and inhibition of Th2 cytokines in promoted antibodies production of immunoglobulin E (IgE), thus reducing immune system overreacts to an allergen.

Taken together, the findings suggested that fennel may be considered as a function food for treatment of infantile colic, however, a large sample size and study by multi centers are necessary to reconfirm the viability.



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) A randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare and Melissa officinalis (ColiMil) in the treatment of breastfed colicky infants by Savino F1, Cresi F, Castagno E, Silvestro L, Oggero R.(PubMed)
(2) The effect of fennel (Foeniculum Vulgare) seed oil emulsion in infantile colic: a randomized, placebo-controlled study by Alexandrovich I1, Rakovitskaya O, Kolmo E, Sidorova T, Shushunov S.(PubMed)
(3) Illicium verum Extract and Trans-Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3+ Regulatory T Cells and Inhibition of Th2 Cytokines in Mice by Yoon-Young Sung,1 Seung-Hyung Kim,2 Dong-Seon Kim,3 Ji-eun Lee,2 and Ho Kyoung Kim1(Hidawi)
(4) Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome by Thompson A1, Meah D, Ahmed N, Conniff-Jenkins R, Chileshe E, Phillips CO, Claypole TC, Forman DW, Row PE.(PubMed)
(5) Comparing the Effects of Echinophora-platyloba, Fennel and Placebo on Pre-menstrual Syndrome by Masoumeh Delaram,1,* Soleiman Kheiri,2 and Mohammad Reza Hodjati(PMC)

#Ashwagandha Protects the Beta Cells of Pancreas Against the Onset of #Diabetes by Enhancing Antioxidant Activity in Vivo

Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream. Insulin resistance and hyperglycemia are hallmarks of diabetes.

In other words, insulin produced by the pancreas is either blocked by the clogging-up of the insulin receptors by fat and cholesterol or the death of beta cells in the pancreas. In some cases, diabetes can also be associated with autoimmune disease, attacking the beta cells.

There are some major types of diabetes, including the best known, type 1 and 2.
* Type 1 diabetes is associated with a genetic proposition that leads to the immune system to attack insulin-producing cells of the pancreas.

* Type 2 diabetes (acquired diabetes), is a condition caused by either the pancreas doesn't produce enough insulin, or the insulin does not work properly due to dysfunction of the insulin receptors.

In pregnancy, gestational diabetes is a type of diabetes occurred during the second or third trimester of pregnancy. Gestation diabetes goes away after giving birth.

However, omen with gestation diabetes is associated with a substantial risk of diabetes developing sometimes in the future.

Epidemiologically, obesity, an unhealthy lifestyle with physical inactivity are some of the most common risk factors associated with the slow onset of diabetes.

Interestingly, some researchers suggested, night shifts workers accompanied by unhealthy lifestyles are linked to a high risk of type 2 diabetes suggested, " risk of type 2 diabetes is actually higher than simply adding the individual risks associated with unhealthy lifestyle and shift work together, indicating that combining an unhealthy lifestyle with irregular night-time working adds a further risk".

"It is well-established that unhealthy lifestyle behaviors such as smoking, a poor diet, little exercise, and being overweight or obese increase the risk of type 2 diabetes. Shift work, especially night shift work, has also been associated with a greater risk of type 2 diabetes".

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

With an aim to find a potent compound for the treatment of diabetes, researchers examined the effects of Withania somnifera (WS) on lipid peroxidation (LPO) and pancreas in type 2 diabetic rats.

The study included type 2 diabetes induced by a single intraperitoneal injection of STZ (100 mg/kg) to 2 days old rat pups pretreated by WS.

According to the tested analysis, the untreated rats' group showed significant levels of lipid peroxidation (LPO) observed by reducing levels of antioxidant enzymes produced by the host including glutathione (GSH) contents, and by enzymatic activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT).

However, injection of WS not only caused a significant decrease in blood glucose and tissue LPO levels caused by the application of STZ but also a significant increase in GSH contents, compared to type 2 diabetic control rats.

Furthermore, antioxidant enzymes reduced in the untreated rat such as GPx, GR, GST, SOD, and CAT were also increased compared to type 2 diabetic control rats.

Most importantly, the significant reduction in the number and size of pancreatic beta-cells in STZ rats was normalized upon the administration of WS, evident from the histopathological examination.

In other words, WS protects the cells in the pancreas against oxidation and maintains the integrity of beta cells in insulin production in type 2 diabetes rats.

Based on the findings, researchers said, "WS has shown strong free radical scavenging activity and helped in improving the non-enzymatic and enzymatic antioxidants in type 2 diabetic rats".

Taken altogether, Ashwagandha WS may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of type 2 diabetes, pending the results of a large example size and multicenter study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective effect of Withania somnifera against oxidative stress and pancreatic beta-cell damage in type 2 diabetic rats by Anwer T1, Sharma M, Pillai KK, Khan G. (PubMed)
(2) Oral supplementation of standardized extract of Withania somnifera protects against diabetes-induced testicular oxidative impairments in prepubertal rats by Kyathanahalli CN1, Manjunath MJ, Muralidhara. (PubMed)
(3) Night shifts and an unhealthy lifestyle linked to high risk of type 2 diabetes by BMJ

#BetaSitosterol Protects the Pancreatic Islets and Inhibits Parameters Against the Risk of Type 2 #Diabetes, According to Studies

Kyle J. Norton

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. By secreting pancreatic juice into the small intestine, the pancreas helps to break down carbohydrates, proteins, and lipids.

Traditional Chinese medicine views the pancreas, as a vital organ that is responsible for the absorption of foods' qi and nutrients before passing them to other organs to nourish our body.
More precisely, the functions of the pancreas including the
* Production of enzymes digest fat, protein, and
carbohydrates.

* Production of juices combined with juices from the intestines to break down protein, carbohydrates, and fat, therefore, it plays an important role in maintaining good health.

* Production of insulin, which is important in regulating the amount of sugar or glucose in the blood.

Pancreatic islets are groups of hormones producing cells, including insulin and glucagon, that work together to maintain the proper level of sugar (glucose) in the blood.

Profound distortion of islet organization in the pancreas has been found to induce account abnormal secretory behavior of the glucagon-secreting A cells in insulin-dependent juvenile-onset diabetes.

Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

As of today, there is no cure for type 1 diabetes. Treatment is focusing on managing blood sugar levels with insulin injection, diet, and lifestyle changes.

According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.

About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, and buckwheat. etc.

In finding a potential phytochemical for the prevention and treatment of infectious diseases, researchers elucidated the anti-diabetic effects of the extract of A. tenuifolia underground parts and β-sitosterol on rat pancreatic islets.

According to the results of the analysis,* The root extract of the plant and compound β-sitosterol isolated from the root extracts showed moderate α-amylase inhibitory activity.
* Furthermore, the herb root extract was able to increase the secretion of insulin in high concentrations (10 mg/mL) and improved the cell viability with no toxicity in all doses.

* The herbal extract could reduce the levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) associated with the onset of oxidative stress in orchestrating damage to the pancreatic islets.

* Moreover, the plant extract also significantly decreased the enzyme activity associated with pro-apoptotic expression by increasing the antioxidant capacity of the isolated cells.


In other words, all compounds found in the extract work synergistically to protect the pancreatic islets by inhibiting all parameters involved in pancreatic damage, particularly, the compound β-sitosterol

Taken altogether, beta-Sitosterol combined with other phytochemicals found in A. tenuifolia underground parts may be considered a supplement for the protection of pancreatic islets-induced diabetes, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Investigation of β-Sitosterol and Prangol Extracted from Achillea Tenoifolia Along with Whole Root Extract on Isolated Rat Pancreatic Islets by Rahimifard M1,2, Manayi A3,2, Baeeri M1, Gholami M4, Saeidnia S3, Abdollahi M. (PubMed)

#Herbal #Chamomile Modulates Enzymes Associated with Hepoprotective Effects, According to Studies

Kyle J. Norton

Chamomile is also known as camomile, the common name of many species of daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as an antispasmodic and anti-inflammatory constituent to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Ingredients

Guaianolides matricarin and achillin, acetoxyachillin and leucodin (= desacetoxymatricarin), corresponding C-11 stereoisomers(a),(Z)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (cis-GMCA), chlorogenic acid, (E)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (trans-GMCA), quercetagetin-7-O-β-d-glucopyranoside, luteolin-7-O-β-d-glucoside, apigenin-7-O-β-d-glucoside, chamaemeloside, apigenin 7-O-(6″-O-acetyl-β-d-glucopyranoside), apigenin] and one polyacetylene (tonghaosu)(b).


Chamomilla Recutita flavonoids (chamiloflan) showed to exhibit antioxidant and anti-inflammatory effects through the induced decrease of ceramide levels in the liver of old rats, according to the Kharkov Karazin National University(1). Flavonoids of German chamomile also exhibited the hepatoprotective effect, through affect sphingolipid metabolism and reducing the elevated ceramide level in the aged liver by normalized activities of key enzymes of sphingolipid turnover (neutral SMase and ceramidase) and ceramide contents in the damaged liver and liver cells, and stabilized the hepatocyte membranes. (2)


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References
(a) Guaianolides and volatile compounds in chamomile tea by Tschiggerl C1, Bucar F.(PubMed)
(b) Quantitative determination of phenolic compounds by UHPLC-UV-MS and use of partial least-square discriminant analysis to differentiate chemo-types of Chamomile/Chrysanthemum flower heads by Avula B1, Wang YH, Wang M, Avonto C, Zhao J, Smillie TJ, Rua D, Khan IA. (PubMed)
(1a) Anxiety disorder(Canadian mental health association)
References
(1) Effects of Chamomilla recutita flavonoids on age-related liver sphingolipid turnover in rats.
Babenko NA1, Shakhova EG.(PubMed)
(2) Effects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells by Babenko NA1, Shakhova EG.(PubMed)