#Avocado Oil Inhibits Parameters Associated with #HighBloodCholesterol, According to Studies

Kyle J. Norton

Avocado may process certain bioactive compounds with the function of inhibiting the abnormal levels of blood cholesterol in the bloodstream, some scientists suggested.

Cholesterol produced by the liver or intake from food sources plays an important role in building the cell membrane walls and stimulating the production of steroid hormones and aiding the digestive tract in absorbing the nutrients for our body needs.

However, a prolonged period of overexpression of abnormal blood cholesterol in the bloodstream can cause plaque building up on the arterial wall, leading to heart disease and stroke.

Depending on the choice of diet, your risk of high blood cholesterol can be increased or decreased.

People who follow the Western diet high in saturated and trans fat, red meat, processed food, and low in fruits and vegetables and whole grains may have a substantially increased risk of abnormally high blood cholesterol.

According to the article "Western Diet and Heart Risk", the author wrote, "“Western diets cause a third of heart attack deaths worldwide,” the Daily Mail reports. Western-style diets high in meat, fat, dairy, and salt put people at higher risk of a heart attack. According to the newspaper, a study has found that poor diet is responsible for 30% of the risk of heart disease".

These results suggested that regardless of the levels of blood cholesterol today, by changing to a healthy diet and lifestyle with moderate exercise, you are at a lower risk of high blood cholesterol in the future (weeks or months, depending on the levels of blood cholesterol today).

The healthy ratio of blood cholesterol is 4 (low-density lipoprotein) to 1 (high-density lipoprotein).

If your ratio is lower than 4, you are considered to have a healthy blood-cholesterol ratio.

Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world.

It is a green-skinned, pear-shaped fruit that ripens after harvesting and is native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

Researchers in the examination of traditionally consumed fruit avocado, use for the treatment of fat lowering capacity launched an experiment to evaluate the effect of hydro-alcoholic fruit extract of P. Americana (HAEPA) on the level of blood lipids, glutathione, lipid peroxidation products, adiponectin, and peroxisome proliferator-activated receptor (PPAR)-γ expressions.

The study includes Male Sprague Dawley rats divided into four groups: groups 1 and 2 were fed normal rat chow (5% fat) and groups 3 and 4 were fed HFD (23% fat) for a period of 14 weeks. In addition, groups 2 and 4 rats were administered orally with 100 mg/kg body weight of HAEPA from the third week.

The rat group treated with additional HAEPA showed a significantly decreased body mass index (BMI), total fat pad mass, and adiposity index, compared to HFD-fed rats.

The LDL and lipid peroxidation levels of the HFD+HAEPA group were significantly lower compared to the HFD group.


Furthermore, Levels of reduced glutathione, an antioxidant enzyme, adiponectin, a protein hormone involved in regulating glucose levels and fatty acid breakdown. mRNA expression of adiponectin, PPAR-γ, and protein expression of PPAR-γ in mediating the expression of fat-specific genes and in activating the program of adipocyte differentiation was found to be increased in the HFD+HAEPA group than in the HFD group.


The findings suggested that HAEPA exhibits antihyperlipidemic activity by increasing the mRNA expression of adiponectin and PPAR-γ, which reduces the risk of hyperlipidemia and obesity.

In a study to examine the avocado oil administration effect on biochemical markers of cardiovascular risk profile in rats with metabolic changes induced by sucrose ingestion 25 rats were divided into five groups: a control group (CG; basic diet), a sick group (MC; basic diet plus 30% sucrose solution), and three other groups (MCao, MCac, and MCas; basic diet plus 30% sucrose solution plus olive oil and avocado oil extracted by centrifugation or using solvent, resp.), researchers found that
* Avocado oil reduces TG, VLDL, and LDL levels, in the LDL case significantly so, without affecting HDL levels.

* Avocado oil exerted a potential effect similar to olive oil in myocardial injury biochemical indicators.

* Avocado oil decreased hs-CRP levels, indicating that inflammatory processes were partially reversed.

Dr. Carvajal-Zarrabal O, the lead author wrote in the final paper, "avocado oil supplementation has a positive health outcome because it reduces inflammatory events and produces positive changes in the biochemical indicators ".

Taken altogether, avocado may be considered functional food for the prevention and treatment of high blood cholesterol without inducing side effects.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Kkarate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity by Monika P, Geetha A.(PubMed)
(2) Avocado oil supplementation modifies cardiovascular risk profile markers in a rat model of sucrose-induced metabolic changes by Carvajal-Zarrabal O1, Nolasco-Hipolito C2, Aguilar-Uscanga MG3, Melo-Santiesteban G4, Hayward-Jones PM1, Barradas-Dermitz DM5.(PubMed)

#Bromelain, in the Form of Nanoparticles (NPs) Inhibits the Genes and Proteins Associated with the Risk of Skin Cancer In Vitro

Kyle J. Norton

Skin cancer is a medical condition caused by irregular cell growth in the skin tissues, due to the alternation of cell DNA.

Most cases of skin cancer in the US are associated with prolong-period of sun exposure. In other words, UV rays that damage the skin have been the main culprit that causes the onset of skin cancer.

Believe it or not, according to the statistics, skin cancer is the most common cancer in the US. one in five Americans will develop skin cancer in their lifetime.

Every day, approximately 9,500 people in the U.S. are diagnosed with skin cancer due to a misunderstanding of the health benefits and risks of sun and tanning exposure.

Most common symptoms at the early stage, are a large brownish spot with darker speckles, a mole that changes in color, size, or feel or that bleeds, a small lesion with an irregular border, and portions that appear red, pink, and white, blue or blue-black.

There are 3 major types of skin cancer, including* Basal cell cancer
It is the most common type of skin cancer associated with the abnormal growth of the cells in the lowest layer of the epidermis. Cancer rarely spreads and kills but can cause significant destruction and disfigurement to the affected skin area, accounting for more than 90% of all skin cancer in the U.S.

* Squamous cell cancer
It arises from the uncontrolled multiplication of transformed malignant cells in the middle layer of the epidermis.

* Melanoma
Melanoma is less common compared to other skin cancer caused by the malignancy of melanocytes, the cell that produced dark pigment for your skin.

Some researchers suggested that by seeking shade, especially between 10 AM and 4 PM. covering yourself with proper sunglasses, clothing, and hat, and using sun protective cream, particularly in avoidance of tanning and UV tanning beds, most types of skin cancer are preventable

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

In the urgency to find a natural ingredient for the treatment of skin cancer, researchers examined the bromelain (BL) effect in the form of nanoparticles (NPs) based delivery systems on skin cancer cells.

The formulated NPs with a mean particle size of 130.4 ± 8.81 nm exhibited sustained release of BL by observation of the analysis.

According to the tested assays, BL-loaded poly (lactic-co-glycolic acid) NPs enhanced anti-tumor effects compared to free BL.

In the tumorigenesis mice model, NPs reduced the average number of tumors by 2.3 folds), delayed tumorigenesis by 2 weeks), and inhibited the percent tumorigenesis by 4 folds.

Furthermore, the administration of NPs also exerted a significant effect on reducing the percent mortality rate and the average tumor volume.

More precisely, NPs demonstrated anti-cancer cell efficacy was attributed to their capability in modulating the expression of pro-apoptotic (P53, Bax) and anti-apoptotic (Bcl2) proteins.

Based on the finding, researchers said, "developed NPs formulation could be used to improve the efficacy of chemotherapy by exerting chemo-preventive effects against induced carcinogenesis at lower dosages".

Additionally, in another mouse skin tumorigenesis model, bromelain not only exerted a similar effect to the aforementioned study it also reduced tumor volume up to a tune of approximately 65%.

In this case, bromelain induced cancer cells apoptosis by stimulating the expression of proteins associated with tumor-suppressive and pro-apoptotic genes, inhibiting the gene involved in anti-apoptosis.

Taken together, bromelain may be considered a supplement for the prevention and treatment of skin cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model by Bhatnagar P1, Pant AB2, Shukla Y2, Chaudhari B2, Kumar P1, Gupta KC. (PubMed)
(2) Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway by Bhui K1, Prasad S, George J, Shukla Y. (PubMed)

#Bakkenolide Isolated Herbal #Butterbur and Its #Extract Exhibit A Cytotoxic Effect Against the Onset of #Cancers, According to Studies

Kyle J. Norton

Scientists may have found a medicinal remedy for the prevention and treatment of cancer with no side effects, according to studies.

Cancer is a class of diseases in which a group of cells grow and multiply in disordered and uncontrollable ways in our body, due to the change of cellular DNA.

Most cases of cancer start in the cells on the surface of the inner lining of the tissue of the organ. At the 0 stage, due to the very small size of the tumor, most patients do not experience any symptoms.

However, at the later stage of the tumor progression, if undetected, the large size of the tumor can suppress and break the nearby small blood vessel, leading to internal bleeding and severe if the tumor also suppresses the nearby nerve cells.

Primary cancer cells at this advanced stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.

Symptoms of cancer at this stage are totally dependent on the affected area, including vomiting blood in oral and lung cancer blood in the urine in bladder cancer. hoarseness in throat cancer. ... Persistent lumps in the breast and lymph cancer and indigestion or difficulty swallowing in digestive-related cancers.

Researchers do not know the exact causes of cancers, but they do know, according to epidemiological studies that age, alcohol cancer, chronic Inflammation, genetic proposition, unhealthy diet, change of hormones use of immunosuppression, infectious agents, obesity, exposure to radiation and sunlight, use of tobacco are most common risk factors associated with the onset of some specific cancers.

Some researchers in the investigation of weakened immune function in the risk of cancer suggested people with a weakened immune system lost the function
1) to stimulate the T cells' inactivation of the B cells in the production of p53, a tumor suppressor gene, or antioncogene that inhibits the cancer cell proliferation and tumor development and

2) to stimulate the production of pro-inflammatory cytokines to kill off the DNA alternated damage cells in the acute phase of inflammation.

In other words, if you have a strong immune system, your risk of cancer is substantially lower compared to the general public.

Butterbur, found in wet, marshy, damp land, including wetlands, riversides, forests, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to the Northern Hemisphere. the herbal plant has been used in herbal medicine used as a pain reliever in the digestive system, including the stomach, bile ducts, duodenum, etc.

The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petition and iso-S-petition, etc.

The Shandong University at Weihai, on finding a natural compound for the treatment of cancer with no side effects examined a new bakkenolide isolated from Butterbur anti-cancer effects.

The new bakkenolide exerted a potent cytotoxic activity against a number of cultured human cancer cells, including human cervical carcinoma (HeLa), human breast cancer (MCF-7), and murine Lewis lung carcinoma (LLC) cell lines.

According to the National Veterinary Research and Quarantine Service in vitro methanol extract from the leaves in the rat liver epithelial cells. significantly decreased spontaneous beta-galactosidase activity and beta-galactosidase activity induced by a mutagen.

Elevated beta-galactosidase (beta-gal) enzyme activity is an indication of the tumor and metastatic expression.

All doses of the extract (0.08-100 mg/plate) decreased the reversion frequency induced by benzo (alpha)pyrene (BaP) in S. Typhimurium TA 98 of the Salmonella typhimurium.

In an additional analysis of the experiment, PJ extract showed greater cytotoxic effects on the human stomach, colon, and uterus cancer cells than on other cancer cell types and normal rat liver epithelial cells.

Furthermore, PJ significantly increased the number of gap junction proteins associated with tumor suppression in a dose-dependent manner.

Dr. the lead scientist said, "Based on these findings, PJ is suggested to contain antimutagenic and anticarcinogenic compounds".

Taken together, herbal Butterbur may be considered a functional remedy for the prevention and combined with the primary medicine for the treatment of cancers.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bakkenolides from Petasites tatewakianus by Dong XW, Li RJ, Gao X, Row KH.(PubMed)
(2) Antimutagenic and anticarcinogenic effect of methanol extracts of Petasites japonicus Maxim leaves by Kang HG, Jeong SH, Cho JH.(PubMed)
(3) Interactions between the tumor suppressor p53 and immune responses by Menendez D1, Shatz M, Resnick MA. (PubMed)

#Herbal #Bilberry Inhibits #Obesity by Suppressing Visceral Fat Accumulation and Hyperglycemia, According to Studies

Kyle J. Norton

In seeking natural therapy with no side effects, scientists may have a herbal remedy that visceral fat accumulation in obesity, according to studies.

Visceral fat is a layer of fat that surrounds the organs. Overexpression of visceral fat has been found to promote insulin resistance, diabetes, heart disease, and inflammation.

Visceral fat obesity is associated with 90% of patients with ischemic heart disease. In obese, accumulation of visceral fat is predominant in the intra-abdominal cavity.

However, in non-obese subjects, visceral fat accumulation is correlated with glucose intolerance, hyperlipidemia, and hypertension.

Obesity is a medical condition caused by excess body fat accumulated to an extent that impacts personal health. The hallmark of obesity is attenuated metabolism and structural cell changes in the obese fat observed by reducing metabolic activity.

According to the statistics provided by the National Center for Health Statistics (2015-2016), in the US, approximately 39.8% of adults aged 20 and over were obese accompanied by another 31.8% overweight.

Obesity rates have increased for all population groups in the US over the last several decades, coincidently with the periods in the promotion of the Western diet.

Dr. Maximilian Tremmel, the lead scientist in the investigation of the economic burden of obesity wrote, "The rising prevalence of obesity represents an important public health issue. An assessment of its costs may be useful in providing recommendations for policy and decision-makers" and "there was great variety in the included obesity-related diseases and complications among the studies".

And, "There is an urgent need for public health measures to prevent obesity in order to save societal resources. Moreover, international consensus is required on standardized methods to calculate the cost of obesity to improve homogeneity and comparability".

The findings strongly suggested that widespread obesity has caused significant pressure on the public health care system and an impact on the financial and economic burden.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

In the urgency to find a natural remedy for the treatment of obesity, researchers examined the effects of anthocyanin-rich phytochemicals found in Aronia fruits (aronia phytochemicals) and bilberry in high-fat-diet-induced dietary obese rats.


During the study, bilberry phytochemicals-supplemented rats showed a significant reduction of total visceral fat mass but to a lesser extent compared to aronia phytochemicals.

Similarly, perirenal and epididymal adipose tissue mass in rats fed aronia phytochemicals was by far greater than the bilberry phytochemicals group.

Bilberry lowered the mesenteric adipose tissue mass.

Bilberry also exerted the equivalently inhibited increases in plasma triglyceride levels, compared to that of aronia phytochemicals with a half-maximal inhibitory concentration (IC(50)) of 1.50 mg/mL.

The results suggest that anthocyanin-rich phytochemicals in aronia fruits and bilberry may have a potency for the treatment of obesity by suppressing visceral fat accumulation and hyperglycemia.

In order to reveal more information about bilberry's anti-obesity properties, researchers evaluated a flavonoid-rich supplement (329 mg/d) on total urine phenolics and shifts in plasma metabolites in overweight/obese female adults.

Participants (N = 103, 18-65 y, BMI ≥ 25 kg/m2) included in the study were randomized to flavonoid (F) or placebo (P) groups for 12 weeks with blood and 24 h urine samples collected prestudy and after 4 and 12 weeks in a parallel design.
The supplement included vitamin C, wild bilberry fruit extract, green tea leaf extract, quercetin, caffeine, and omega-3 fatty acids.

According to the urinary assay, in the 4 weeks, urine total phenolics increased 24% in F versus P with similar changes at 12 weeks.

In of F demonstrated the shifts in 63 biochemicals compared to P with 70% from the lipid and xenobiotics super-pathways, according to the examination of metabolomics assay.

Where metabolite profile is reflective of metabolic processes, including pathophysiological changes characteristic of obesity-related complications.

The findings suggested that flavonoid-rich supplements may have a strong effect on the change of metabolome which is the sum of all the small-molecule chemicals found in a biological sample, often the blood plasma, and considered a measurement of obesity and health beyond BMI.

Taken together, bilberry used alone or combined with other agents may be considered functional remedies for the prevention and treatment of obesity, pending to the confirmation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Anthocyanin-rich Phytochemicals from Aronia Fruits Inhibit Visceral Fat Accumulation and Hyperglycemia in High-fat Diet-induced Dietary Obese Rats by Takahashi A1, Shimizu H, Okazaki Y, Sakaguchi H, Taira T, Suzuki T, Chiji H. (PubMed)
(2) Influence of Ingesting a Flavonoid-Rich Supplement on the Metabolome and Concentration of Urine Phenolics in Overweight/Obese Women by Nieman DC1, Ramamoorthy S2, Kay CD3, Goodman CL1, Capps CR1, Shue ZL1, Heyl N1, Grace MH3, Lila MA. (PubMed)
(3) Economic Burden of Obesity: A Systematic Literature Review by Maximilian Tremmel,1,* Ulf-G. Gerdtham,2,3,4 Peter M. Nilsson,5 and Sanjib Saha. (PMC)

#Tomato Protects Diabetes Against Complications Through Its Antioxidant Activity, Researchers Say

Kyle J. Norton

Oxidative stress is an imbalanced ratio of free radicals and antioxidant enzymes produced by the host.
In other words, diseases associated with oxidative stress such as cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer are results of the prolonged period of overexpression free radicals compared to reduced levels of antioxidants.

Free radicals are unstable molecules with a single electron in the outer ring. Therefore, in order to become stable, free radicals readily steal or donate an electron from other molecules, leading to a free radical cascade that cannot be stopped until all outer ring electrons are paired or inhibited by antioxidants.

Antioxidants are stable molecules that inhibit oxidation.

Diabetes is a chronic condition of insufficient insulin entering the bloodstream, caused either by the gradual died-off of the beta cells in the pancreas or insulin receptors clogged-up by cholesterol.

In our body, free radicals induced by cell metabolism for the body to function normally are inhibited by the antioxidant either produced by the body or the intake of antioxidant chemical compounds from dietary sources.

Free radicals can enter our body from environmental factors, such as the air we breathe, and the foods we eat.

Some researchers suggested that the reduced levels of antioxidants against the overexpression of free radicals most likely occurred in people with a weakened immune system such as the elderly due to aging.

Dr. Viviana I Pérez, the lead scientist said, "Currently, the Oxidative Stress (or Free Radical) Theory of Aging is the most popular explanation of how aging occurs at the molecular level".

And, "While data from studies in invertebrates (e.g., C. elegans and Drosophila) and rodents show a correlation between increased lifespan and resistance to oxidative stress (and in some cases reduced oxidative damage to macromolecules), direct evidence showing that alterations in oxidative damage/stress play a role in aging".

Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On finding a natural compound for the treatment of diabetes with no side effects, researchers examined the beneficial effect of tomatoes in diabetics.

Participants in the type-II diabetic group (n=40) and age-matched control group (n=50 are included in the study.

Before treatment, the type-II diabetic group showed significantly lower levels of antioxidant enzymes and a very high lipid peroxidation rate compared to the control group.

According to the analysis of the short term supplementation, tomatoes (cooked) showed a significant improvement in antioxidant enzyme levels and decreased lipid peroxidation rate in the diabetic group for a period of 30 days.

Once again, in a total of 90 subjects including type 2 diabetic group (n = 40) and an age-matched control group (n = 50), researchers once against investigated the anti-diabetes activity of lycopene.

Patients with type 2 diabetes have significantly lower levels of antioxidant enzymes and very high lipid peroxidation, as well as higher levels of lipid profile and glycated hemoglobin (HbA1c), compared to controls before the application of lycopene.

Long-term tomato supplementation in diabetes mellitus showed a significant improvement in the levels of antioxidant enzymes and decreased lipid peroxidation rate (p < 0.001), with no effect on lipid profile and glycated hemoglobin HbA1c levels.

In other words, long-term tomato injection protects diabetics against complications associated with abnormally high levels of high blood glucose and lipid, through its antioxidant activity.

Taken altogether, tomatoes may be considered supplements for the prevention and treatment of complications caused by oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Effect of short-term supplementation of tomatoes on antioxidant enzymes and lipid peroxidation in type-II diabetes by Subhash K1, Bose C, Agrawal BK. (PubMed)
(2) Effect of long-term supplementation of tomatoes (cooked) on levels of antioxidant enzymes, lipid peroxidation rate, lipid profile, and glycated hemoglobin in Type 2 diabetes mellitus by Bose KS1, Agrawal BK. (PubMed)
(3) Is the Oxidative Stress Theory of Aging Dead? by Viviana I Pérez,1,2 Alex Bokov,1,3 Holly Van Remmen,1,2,4,6 James Mele,4 Qitao Ran,1,2Yuji Ikeno,1,5,6 and Arlan Richardson. (PMC)

#Apricots Process Anti #Liver and Lung Cancer Properties, According to Researchers

Kyle J. Norton

Apricot, a functional food may be the next pharmaceutical target for the finding of an effective medicine with potential in the treatment of liver cancer, some scientists suggested.

Liver cancer is a medical and chronic condition caused by irregular cell growth in the liver tissue.
What causes the mutation of liver cell DNA is unknown. However, according to epidemiological studies, cancer originating from the liver is associated with livers damaged by birth defects, alcohol abuse, or chronic infection with diseases such as hepatitis B and C, and hemochromatosis.

Non-alcoholic steatohepatitis (NASH), is the advanced form of non-alcoholic fatty liver disease (NAFLD). are one of the major risk factors associated with significant liver damage or the increased risk of liver cancer.

An unhealthy diet pattern and lifestyle also can contribute to the early onset of liver cancer. therefore making positive lifestyle choices such as Not smoking, eating a healthy diet, and keeping physically active are some of the ways can reduce the risk of liver cancer.

The World Cancer Reserve Fund wrote," There is strong evidence that being overweight or obese is a cause of liver cancer, consuming approximately three or more alcoholic drinks a day is a cause of liver cancer, and consuming foods contaminated by aflatoxins (toxins produced by certain fungi) is a cause of liver cancer".

Men are about 3 times more likely than women to be diagnosed with the disease

According to the statistic, in the US., an estimated 30,610 men and 11,610 women will be diagnosed with primary liver cancer, causing the deaths of 20,540 men and 9,660 women.


The apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belonging to the family Rosaceae.

Apricot is classified in the family of the plum with yellow to orange, often tinged red on the side which is exposed to the sun.

Chemical constituents of apricot include
Oleic acid, linoleic acid, palmitic.acid, glycolipids, phospholipids, benzoic acid (I), isorhamnetin (II), quercetin (III), kaempferol-3-O-beta-D-galactopyranoside (IV), isorhamnetin-3-O-beta-D-glucopyranoside (V), isoquercitrin (VI), hypericin (VII) and rutin (VIII)(a) and flavonoid glycosides.

In the assessment of MK615, an anti-cancer substance extracted from the Japanese apricot, researchers at the Dokkyo University School of Medicine conducted an investigation to examine the anti-neoplastic effect of MK615 against hepatocellular carcinoma (HCC).

Observation of the assays from 2 HCC lines, HuH7 and Hep3B, were cultured with MK615 at concentrations of 600, 300, 150, and 0 microg/mL found that
* MK615 inhibited the growth of, and lysed, HuH7 and Hep3B cells in a dose-dependent manner

* MK615 decreased the population of cells in the G2/M phase, according to the Cell cycle analysis.

* MK615 suppressed the expression of the function of Aurora A. associated with cancer cell proliferation by 34.3%, 32.9%, and 54.3% at 150, 300, and 600 microg/mL MK615, respectively.

Dr. after taking into account co and confounders said, "(These results suggested that) MK615 has an anti-cancer effect against HCC lines in vitro, and the effect is exerted through inhibition of Aurora-A activity".

Furthermore, in the evaluation of the clinical effects and feasibility of administering MK615 for patients with HCC recurred in the liver 8 mo after the surgery, in a 60-year-old female with advanced HCC, researchers found that

* Radiofrequency ablation and transarterial infusion chemotherapy were performed but the recurrence was not controlled and one year after the intrahepatic recurrence, pulmonary and lymph metastasis reappeared.

* Administration of chemo drug Sorafenib was not effective.

* MK615 was administered as a final alternative therapy after informed consent was obtained from the patient.

3 months of MK615 injection exerted a significant effect in decreasing her alpha-fetoprotein level and sizes of both the lymph node and pulmonary metastases. The patient has survived for more than 17 mo after the MK615 administration

These results suggested that MK615 is effective against advanced liver cancer metastases.
Taken together, apricot may be considered a functional food for the prevention and adjunct therapy for the treatment of liver cancer.

However, further data collection large example size and multi-center studies performed with human consumption of the whole food apricot during the course of the disease will be necessary to complete the picture of apricot anti-liver cancer possibilities.


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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources

(1) A novel anti-cancer substance, MK615, from ume, a variety of Japanese apricot, inhibits the growth of hepatocellular carcinoma cells by suppressing Aurora A kinase activity by Okada T1, Sawada T, Osawa T, Adachi M, Kubota K.(PubMed)
(2) Advanced hepatocellular carcinoma responds to MK615, a compound extract from the Japanese apricot "Prunus mume" by Hoshino T1, Takagi H, Naganuma A, Koitabashi E, Uehara S, Sakamoto N, Kudo T, Sato K, Kakizaki S.(PubMed)

The Peels and Seeds #Extract in #Avocado Process Anti-Lipids, Proteins Associated with Cells DNA Damage Activity, Researchers Find

Kyle J. Norton

In the search of natural therapy for the prevention and treatment of diseases involved oxidative stress, scientists may have found a dietary whole fruit with the efficacy compared to that of conventional medicine, according to studies.

Antioxidants are stable atoms that inhibit free radical and stop the free radicals chain reaction.

Free radicals on the other hand are unstable and highly reactive molecules with a single or unpaired electron on the outer ring. In order to maintain the balance, free radicals are ready either to donate or intercept an electron from another stable atom, leading to a domino effect which can not be stopped until the electron is paired or inhibited by an antioxidant.

Overexpression of free radicals and suppressed levels of antioxidants cause oxidative stress, leading to the damage of cell structure, protein, and lipid and alternation of cell DNA.

Every day, the human body is bombarded by the invasion of free radicals. Some foods we eat, the polluted air we breathe, the use of toxic chemical substances, and the body metabolism all contribute to the expression of free radicals in our body.

Luckily, for a healthy individual, our body's antioxidant enzymes are good enough to maintain the balance ratio, regardless of the levels of free radicals produced.

However, for people with suppressed antioxidant enzymes in the body, dietary sources of antioxidants from fruits and vegetables can be very helpful.

Researchers at the Karolinska Institutet suggested that a high intake of fruit and vegetables is related to low oxidative stress.

Dr. Rikard Åsgård, the lead scientist said, "Fruit and vegetable intake was inversely related to oxidative stress" and " An increased intake of fruit and vegetables can, therefore, be beneficial for patients with type 2 diabetes since these patients are documented to have raised oxidative stress and inflammation".


The results clearly encouraged that people who suppress antioxidants produced by the body should add some portions of fruits and vegetables into their diet.

Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and is native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

With an aim to find natural ingredients with significant antioxidant effects against bacterial infection in the induction of oxidative stress, researchers examine the thyl acetate, containing 70% acetone, and 70% methanol extracts of the peel, pulp, and seed from two avocadi (Persea Americana Mill) against Gram-positive bacteria.

Peels and seeds were found to possess higher amounts of phenolics and had a more intense in vitro antioxidant potential, compared to the pulp.

The efficacy of the peels and seeds against Gram-positive bacteria was associated with the rich in catechins, procyanidins, and hydroxycinnamic acids, whereas the pulp was particularly rich in hydroxybenzoic and hydroxycinnamic acids and procyanidins.

The results indicated that avocado displays moderate antimicrobial effects against Gram-positive bacteria.

Furthermore, with the injection of the extracts (70% acetone) from avocado peels and seeds as inhibitors of oxidative reactions in meat patties, researchers also found that avocado extracts protected meat lipids and proteins against oxidation with the effect on lipids being dependent on the avocado variety.


Moreover, in the examine the antioxidant activity of other compounds such as monounsaturated fatty acids, tocopherols, carotenes, acetogenins and sterols found in avocado researchers once again confirmed the antioxidant property by comparing the lipophilic AOC of the pulp and the fruit hydrophilic AOC.

According to the chemical assay of oxygen radical absorbance capacity (ORAC), the highest antioxidant activity of lipophilic AOC was attributed to the presence of high levels of acetogenins, compared to other compounds.

The findings showed that the presence of emulsifying agents which are soluble in both fat and water could serve as novel lipophilic antioxidants in a food matrix.

Interestingly, the University of California in the study "the effect of harvest date on nutritional compounds and antioxidant activity (AOC) in avocado (Persea Americana Mill. cv Hass) fruit", suggested that AOC in early harvested fruit after storage for 35 days was much higher antioxidant contents than that in late-harvested fruit after storage for 21 days.

Taken together, there is no doubt that whole fruit avocado processed strong antioxidant properties may be considered a functional food for the prevention and treatment of oxidative stress-related diseases


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Avocado (Persea americana Mill.) phenolics, in vitro antioxidant and antimicrobial activities, and inhibition of lipid and protein oxidation in porcine patties by Rodríguez-Carpena JG1, Morcuende D, Andrade MJ, Kylli P, Estévez M.(PubMed)
(2) Activity-guided identification of acetogenins as novel lipophilic antioxidants present in avocado pulp (Persea americana) by Rodríguez-Sánchez D1, Silva-Platas C, Rojo RP, García N, Cisneros-Zevallos L, García-Rivas G, Hernández-Brenes C.(PubMed)
(3) Effect of harvest date on the nutritional quality and antioxidant capacity in 'Hass' avocado during storage by Wang M1, Zheng Y, Khuong T, Lovatt CJ.(PubMed)
(4) High intake of fruit and vegetables is related to low oxidative stress and inflammation in a group of patients with type 2 diabetes by Rikard Åsgård,1 Elisabet Rytter,2 Samar Basu,2 Lilianne Abramsson-Zetterberg,3Lennart Möller,1 and Bengt Vessby. (PMC)