#RapeseedOil Inhibits The Clusters of Metabolic Syndrome Associated with CardiovascularDisease and Non Fatty #LiverDiseases

Kyle J. Norton

Metabolic syndrome is a cluster of conditions associated with the increased risk of cardiovascular disease and diabetes.

The health problems found in the group include too much fat around the waist, elevated blood pressure, high triglycerides, elevated blood sugar, and low HDL cholesterol.

In other words, if you have 3 of the conditions in the group, your risk of CVD and diabetes are increased substantially compared to those who have less.

According to the statistics, approximately 30% of people in the US are living with metabolic syndrome.

Believe it or not, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 1988–1994 to 2007–2012, increasing from 25.3% to 34.2%.

Rapeseed, also known as rape, or oilseed rape, is a member of the family Brassicaceae (mustard or cabbage family), cultivated in suitable climate regions for its oil-rich seed for commercial profits.

To find a potential compound for the prevention of heart disease, researchers at the University of Applied Sciences investigated the effects of a hypo energetic diet with low energy density (ED) enriched in rapeseed oil-derived n-3 fatty acid α-linolenic acid (ALA), in patients with metabolic syndrome.

The human trial included eighty-one patients with metabolic syndrome randomly assigned to receive either rapeseed oil derived with high MUFA content and an ALA intake of 3.5 g/d on body weight or olive oil diet rich in MUFA but with a low ALA content.

According to the results, after a 6-month dietary intervention, the rapeseed oil and olive oil groups showed a significant in reduced body weight and metabolic factors associated with cardiovascular risk.

In other words, intervention groups with rapeseed oil not only significantly decrease the systolic blood pressure, but also reduce total cholesterol and LDL-cholesterol, and insulin levels in patients with metabolic syndrome.

More interestingly, serum triglycerides (TAG) associated with cardiovascular and nonfatty liver disease risk factors were significantly reduced only in the high ALA intake, compared to no effect on the low ALA group.

Based on the findings, researchers said, "Our dietary food pattern with a low ED and high intakes of MUFA and ALA may be a practical approach for long-term dietary treatment in patients with the metabolic syndrome".

Taken altogether, rapeseed oil may be considered a supplement for the prevention and treatment of metabolic syndrome, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of a rapeseed oil-enriched hypo energetic diet with a high content of α-linolenic acid on body weight and cardiovascular risk profile in patients with the metabolic syndrome by Baxheinrich A1, Stratmann B, Lee-Barkey YH, Tschoepe D, Wahrburg U. (PubMed)

#Strawberries Inhibit Parameter Inflammatory Expression Against the Onset of Type 2 #Diabetes, According to Studies

Kyle J. Norton

The rise of obesity associated with the increase in the incidence of Type 2 diabetes has been a significant burden on healthcare systems in many countries.

Strawberry processed abundant phytochemicals may be the next target for pharmaceutical companies to extract a single ingredient for the treatment of type 2 diabetes, some scientists suggested.

Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose as the result of either cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.

Researchers do not why people with similar health conditions, diet, and family history are susceptible to the development of insulin resistance, the early stage of diabetes while others do.

Some researchers suggested that genetic proposition and unhealthy lifestyle accompanied by physical activity are the most common risk factors associated with the onset of type 2 diabetes.

Dr. Karla C. Paz-Salinas, the lead author in the study "Do People with Type 2 Diabetes Think They are Unhealthy?" wrote, "A healthy lifestyle and understanding of diabetes management are important factors for delaying the onset of comorbidities associated with Type 2 diabetes".

In genetic preposition front, researchers at the Medical College of Wisconsin, said, "Very few T2D risk genes were identified using candidate gene and linkage-based studies, but the advent of genome-wide association studies has led to the identification of multiple genes, including several that were not previously known to play any role in T2D. Highly genes, for example, TCF7L2, KCNQ1, and KCNJ11 are discussed in greater detail".

We can not prevent the onset of type 2 diabetes caused by a genetic mutation, however, the risk of type 2 diabetes can be reduced substantially and type 2 diabetes can be easily managed if we are following the healthy lifestyle that processes the diet high in fruits and vegetable, less in saturated and trans fat, red meat and processed food with moderate exercise.

Strawberry is a genius of Fragaria × ananassa and belongs to the family Rosaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.

The major chemical compounds of strawberry include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.

In the finding of a natural ingredient for the treatment of diabetes with no side effects, researchers at the University of California launched a study to examine the anti-inflammatory and blood glucose (BG)-regulating the capacity of strawberries in a mouse model of diet-induced obesity.

In a total of thirty-six male C57BL/6J mice were included in the study randomly divided into four groups (nine mice per group), including mice fed a low-fat diet (LF, 13 % fat), the LF supplemented with 2·6 % freeze-dried strawberry powder (LFSB), a high-fat diet (HF, 44 % fat) or the HF supplemented with 2·6 % strawberry powder (HFSB).

The dietary intake of SB approximated one human serving of strawberries

Before the administration of strawberry powder, a blood sample of HF group showed an increased non-fasted BG, insulin, soluble intracellular adhesion molecule-1, the important biomarkers for inflammatory processes involving activation or damage to cells, E-selectin, leptin, resistin, and plasminogen activator protein-1, the indication of the inflammatory process.

High dietary fat decreased IL-4 production, an anti-inflammatory cytokine from activated splenocytes, the white blood cells.

The levels of BG concentrations were lower in the mice supplemented with SB (10·64 mmol/l) compared to the non-supplemented mice.

BG values were approximately 6·5 % lower in the supplemented mice.

These results firmly supported a promising role for dietary strawberries in reducing the risks associated with obesity and diabetes and regulating the levels of inflammatory markers in non-obese individuals.

The study was published Nov 28 in the US National Library of Medicine and National Institutes of Health. You can view the abstract by clicking the link in the resources box.

Please note that strawberry contains a measured amount of oxalates, if you have kidney disease, please check with your doctor before applying.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Dietary strawberry powder reduces blood glucose concentrations in obese and lean C57BL/6 mice and selectively lowers plasma C-reactive protein in lean mice by Parelman MA, Storms DH, Kirschke CP, Huang L, Zunino SJ. (PubMed)
(2) Do People with Type 2 Diabetes Think They are Unhealthy? by A Cross-Sectional Study in Celaya, Mexico by Karla C. Paz-Salinas,1 Nicolas Padilla-Raygoza,1,2 Silvia C. Delgado-Sandoval,1,2Georgina Olvera-Villanueva,1,2 and Ma Laura Ruiz-Paloalto. (PMC)

#Healthyfood #Onion Inhibits #Vascular #ndothelial Dysfunction Against the Risk of #CardiovascularDisease, Scientists Suggest

Kyle J. Norton

Vasoprotection is the process to improve the function of the blood vessels, including the use of herbal and natural remedies.

Blood vessels are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart.

There 3 main types of the blood vessel are arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body. Damage of arteries may induce coronary artery disease associated with the narrowing or blockage of the coronary arteries due to plaques accumulated on the arterial wall.

The veins that carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with a disease of the veins that affects up to 20 percent of adults.

The capillaries or the smallest blood vessels have been found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.

Endothelial dysfunction is a condition characterized by the damage of the vascular endothelium, the thin layer of cells that lines blood vessels, a leading cause of the cardiovascular disease (CVD).

In other words, vascular endothelium dysfunction reduced the function of targeting free radicals that lead to the onset of oxidative stress.

The most common risk factors associated with vascular endothelium dysfunction are impaired vasodilation, deficiency of nitric oxide, inflammation, and thrombosis.

Dr. Hirata Y. at The University of Tokyo.wrote, "Vascular endothelial dysfunction reflected by reduced nitric oxide (NO) availability is certainly the causative factor or promoting mechanism of arteriosclerosis. It is necessary to detect endothelial dysfunction at an early stage using appropriate methods, and to choose a treatment for the recovery of endothelial function".

And, "There are nonpharmacological and pharmacological therapies to attain endothelial repair. The former includes bodyweight reduction, aerobic exercise, and restriction of salt intake, while the latter includes the use of renin-angiotensin system inhibitors, calcium antagonists, some types of beta-blockers, statins, erythropoietin, tetrahydrobiopterin, and antioxidants".

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
On finding a potent ingredient which processes vasoprotective activity researchers examined quercetin, a dietary polyphenol found abundantly in onion on vascular endothelial dysfunction (VED).

Epidemiologically, quercetin showed significant activity against the VED complication in the induction of oxidative stress, impaired vasodilation, platelet aggregation, and monocyte adhesion leading to the early event of morbidity and mortality in patients with cardiovascular disease (CVD).

Quercetin efficacy which protects against VED and decreases CVD risk was attributed to its antioxidant, vasodilatory, anti-platelet, and anti-atherogenic activities.

Futhermore, in vitro, quercetin exerted multiple actions on the NO-guanylyl cyclase pathway associated with the smooth muscle tone in bronchi or vessels, endothelium-derived hyperpolarizing factor(s) and endothelin-1 involved in vasoconstriction and endothelial function.

Moreover, the phytochemical also protected endothelial cells against apoptosis.

In vivo, quercetin prevented endothelial dysfunction by reducing blood pressure, oxidative stress and end-organ damage in hypertensive animals.

In other words, regular intake of quercetin improves the endothelium functioning against the risk of VED inducing cardiovascular disease, particularly in patients with hypertension and ischemic heart disease.

Taken together, onion processed with a higher amount of quercetin may be considered a remedy for the prevention and treatment of vascular endothelial dysfunction, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Vasoprotective activities of quercetin by Richard S Bruno. (Research Gate)
(2) Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols by Perez-Vizcaino F1, Duarte J, Andriantsitohaina R. (PubMed)
(3) Diagnosis and treatment of endothelial dysfunction in cardiovascular disease by Hirata Y1, Nagata D, Suzuki E, Nishimatsu H, Suzuki J, Nagai R. (PubMed)

#Herbal #Cleaver inhibits Pathways Associated with #Melanoma Cell Metastasis in Vitro, Researchers Say

Kyle J. Norton

Skin melanoma is a skin cancer characterized by the alternation of the pigment-containing cells known as melanocytes. However, in rare cases, melanoma can also occur in the mouth, intestines, or eye.

Most cases of melanoma start in melanocytes on skin before spreading to the nearby tissue. In the advanced stage, the cancer cells can also travel a distance away from the originated site to infect other tissues and organs, leading to secondary metastasis, through the circulation of blood and fluids.

The most common sites of melanoma metastasis are the lung and breast.

The most common symptoms are visible by examing the change of skin, including the sores that can not heal itself, redness or swelling, persistent itching, tenderness and pain and particular, change of skin color and bleeding off of a mole compared to the normal moles.

The 4 most common types of skin melanoma include
* Superficial spreading melanoma, the type of cancer has a tendency to spread grow outward and spread across the surface of the skin, accounted for 70% of all melanoma skin cancer.

* Nodular melanoma normally grows down into the skin and has a tendency to spread more quickly than other types of melanoma skin cancer.

* Lentigo malignant melanoma, most common in the older population, makes up approximately 15% of all melanoma skin cancer.

* Acral lentiginous melanoma, most common in people with darker skin. Cancer first moves outward before spreading deeper into the skin.

According to the statistics provided by the American Cancer Society, in 2019, approximately, 96,480 new melanomas will be diagnosed (about 57,220 in men and 39,260 in women) in the US. The condition also causes the death of 4,740 men and 2,490 women.

Believe it or not. most cases of melanoma are found in older adults. The average age diagnosed with melanoma is 63.

Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.

In finding a potential compound for the treatment of skin diseases, researchers investigated the Gallic acid (GA) found in herbal Cleaver in the inhibition of the growth of human cancer cells in vitro and in vivo.

GA decreases the expression of MMPs MMPs mRNA levels in A375.S2 human melanoma cells in stimulating the cancer cell metastasis.

Furthermore, GA processed antimetastatic potential by decreasing the invasiveness of cancer cells.

Moreover, this action of GA was involved in the Ras, p-ERK signaling pathways with the function to communicate a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell to induce the inhibition of MMP-2 associated with cancer spreading in A375.S2 human melanoma cells.

Based on the findings, researchers said, " These data, therefore, provide evidence for the role of GA as a potential cancer chemotherapeutic agent, which can markedly inhibit the invasive capacity of melanoma cells".
o

Taken altogether, Comfrey may be considered a remedy to inhibit cancer call spreading, pending to the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Gallic acid inhibits the migration and invasion of A375.S2 human melanoma cells through the inhibition of matrix metalloproteinase-2 and Ras by Lo C1, Lai TY, Yang JS, Yang JH, Ma YS, Weng SW, Lin HY, Chen HY, Lin JG, Chung JG. (PubMed)

#Omega-3 Fatty Acid's #Omegaven Combined with Chemo-Drugs Exerts A Significant Effect on #AdvancedEsophagogastricCancer

Kyle J. Norton

Cancer is a class of diseases characterized by cell growth and multiplied disorderly and uncontrollably. In the advanced stage, cancerous cells from the originated site can travel a distance away to infect other healthy tissue via lymph or blood circulation.

Most cancers process a high survival rate if they are diagnosed early. According to the Mayo Clinic, over 56 percent of people diagnosed with early-stage lung cancer live for at least five years after diagnosis. However, the five-year survival rate for people diagnosed with late-stage of invasive lung cancer is 5 %.

According to the statistic on Canadian cancer provided by the government, in 2017, there were over 200,000 newly diagnosed cancer and 80,000 Canadians died from cancer. 1 in 2 Canadians will be diagnosed with cancer, and 1 in 4 will die from the disease, during their lifetime.

The exact cause of cancers is unknown. Researchers do not know why some people without gene mutation are susceptible to early onset of cancer while others do not

However, researchers do know that certain risk factors such as aging, tobacco, sun exposure, radiation exposure, chemicals, and other substances, some viruses and bacteria, certain hormones, family history of cancer, alcohol, poor diet, and physical inactivity are associated to gene change in the initiation of cancer development.

Most cancers share the common symptoms of tiredness, unexplained weight loss, loss of appetite, and fatigue. In the advanced stage, cancer patients may also experience additional common symptoms of dehydration, nausea and vomiting, constipation, and persistent pain.

Gastroesophageal adenocarcinoma is a rare type of cancer of the esophagus, the tube that connects your mouth and stomach.

The most common risk factors associated with the onset of esophagogastric adenocarcinoma are
* Having gastroesophageal reflux disease (GERD)
* Smoking.
* Having precancerous changes in the cells of the esophagus (Barrett's esophagus)
* Being obese.
* Excessive alcohol drinking
* Frequent bile reflux.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

In finding a potential phytochemical for the treatment of cancer, researchers investigated the effects of omega-3 fatty acids in patients with advanced esophagogastric adenocarcinoma.

The study included 20 participants with advanced esophagogastric adenocarcinoma enrolled in phase II single-arm clinical trial of palliative chemotherapy (epirubicin, oxaliplatin, and capecitabine; EOX) coupled with the weekly infusion of Omegaven®.
According to the results of radiological responses,
* Partial response (EOX plus omega-3 group 73% vs. EOX alone 39%, p=0.03).

*Stable disease (EOX plus omega-3 21% vs. EOX alone 39%, p=0.24), and

* Progressive disease (EOX plus omega-3 7% vs. EOX alone 18%, p=0.34).

Most importantly, grade 3 or 4 toxicity was less common (thromboembolism & gastrointestinal) and the concentrations of pro-inflammatory proteins such as IL-2 (p=0.009), TNF-α (p<0.0001), and VEGF (p=0.002) was reduced. in those who received EOX plus omega-3.

Based on the evidence, researchers said, "The treatment with supplementary omega-3 fatty acids reduced chemotherapy-related toxicity and resulted in better radiological responses".

Taken together, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered an adjunct therapy in the treatment of advanced esophagogastric adenocarcinoma, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Effect of Supplementary Omegaven® on the Clinical Outcome of Patients With Advanced Esophagogastric Adenocarcinoma Receiving Palliative Epirubicin, Oxaliplatin, and Capecitabine Chemotherapy: A Phase II clinical trial by Eltweri AM1, Thomas AL2, Chung WY3, Morgan B3, Thompson J4, Dennison AR3, Bowrey DJ. (PubMed)

#Proanthocyanidins (PA) Found in #CrampBark Exert Gastroduodenoprotective Property through Its Antioxidant Activities, Researchers Find

Kyle J. Norton

The digestive system included the gastrointestinal tract, the liver, pancreas, and gallbladder play a critical role to maintain the body normal function by providing nutrients and fluids to the body and remove waste through the secretary system.

The gastric mucosa is the mucous membrane layer of the stomach that plays a critical role in providing physical protection against ingested particles and preventing the contact between digestive enzymes such as pepsin and the underlying mucosa.

On the other hand, the gastric mucosal barrier protects the stomach against gastric acid that is required for digestion.

Dr, Lawson HH. in the classification of the different histologic types of the normal human duodenal mucosa suggested that there are antral type-duodenal mucosa, the transitional-type duodenal mucosa, and the jejunal-type duodenal mucosa.

The three different types of mucosa vary in their degree of susceptibility to the effect of acid hypersecretion, leading to duodenitis and gastritis and worsens the condition of ulcer.

The function of duodenum mucosa is to increase its surface area that contacts with chyme passing through the intestinal lumen and improves the absorption of nutrients.

Abnormal duodenal mucosa can lead to acute and chronic duodenal ulcers.

Cramp Bark is an ornamental plant, genus Viburnum, belonging to the family Adoxaceae, native to Europe and Asia. It has been used in traditional and herbal medicine as an anti-spasmodic, anti-inflammatory, and nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with menopause, etc.


In finding a potential herbal medicine for the protection of digestive function, researchers examined the gastrointestinal mucosal defense mechanisms of proanthocyanidins (PA), the polymers of flavan-3-ols, isolated from the Viburnum opulus (VOPA, Caprifoliaceae).

According to the tested assays of rats exposed to non-topical ulcerogens (stress) without and with capsaicin (125 mg/kg, sc) denervation, VOPA showed strong effects in the promotion of the gastroduodenal mucosal integrity and pattern, observed by the carbohydrate-binding proteins and nitric oxide (NO) content that protects the intact mucosa.

The levels of antioxidant enzymes produced by the tested rats such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were also significantly higher in the VOPA group at doses of 25, 50, or 75 mg/kg body weight.

In other words, VOPA inhibited lipid peroxidation by enhancing the production of antioxidant enzymes produced by the host.

Based on the findings, researchers said, "VOPA exerts a potent gastroduodenoprotective activity via an increase in endogenous NO generation, suppression of lipid peroxidation and mobilization of antioxidant activity and changes in glycoconjugate content of the gastroduodenal mucosa of rats".

Taken altogether, cramp bark(Viburnum opulus) may process the gastroduodenoprotective effects, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Influence of Viburnum opulus proanthocyanidins on stress-induced gastrointestinal mucosal damage by Zayachkivska OS1, Gzhegotsky MR, Terletska OI, Lutsyk DA, Yaschenko AM, Dzhura OR. (PubMed)
(2) The duodenal mucosa in health and disease. A clinical and experimental study by Lawson HH. (PubMed)

#Honey Inhibits Proteins Associated with the Cell Death Programming and Cancer Cell Apoptosis Against the Onset of Breast Cancer

Kyle J. Norton

Scientists may have found a sweet whole food which processes a strong effect in the prevention and treatment of breast cancer, according to some studies.

Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.

Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.

In the early stage, most patients with breast cancer may experience lumps on the breast or surrounding the breast.

However, breast skin irritation or dimpling, nipple pain, nipple retraction (turning inward), redness and scaliness that cannot be healed within 3 weeks are also the signs and symptoms of breast cancer.

At the later stage, after colonizing most parts of the breast, the breast cancer cells may travel a distance far the way to infect other healthy cells and tissue.

In Canada, according to the statistic, 11% of women will develop breast cancer by the time they reach 90 years of age.

Just about 20% of breast cancers in Canada are diagnosed in women under 50, while almost 30% are diagnosed in women over 70 years of age.


These results suggested that the most common risk factor to fuel the onset of breast cancer is the increase in age.

The concern of the increasing number of studies indicates that the strength and even direction of the association between breast cancer and established risk factors differ according to the woman's age when she develops the disease, Dr. Tryggvadóttir L, the lead scientist. according to the result of the study of a cohort of 80.219 women attending population-based cervical and breast cancer screening in Iceland, 1120 cases were identified, aged 26-90 years at diagnosis, and 10,537 controls, individually matched to the cases on birth year and age when attending wrote at the final report, "age at diagnosis should be taken into account when studying the effects of breast cancer risk factors".

Sadly to let you know that 60% of women who carry the genetic mutation of gene BRCA1 and 2 have breast cancer developed before the age of 70.

Other risk factors associated with the onset of breast cancer are reproductive history of having a dense breast, personal and family history, previous intake of the drug diethylstilbestrol (DES), and previous radiotherapy.

Regardless of all risk factors, women's breast self-examinations are still the most important methods to have breast cancer diagnosed early and increase the years of survival.

According to the worldwide statistic, the 5 survival rate of the early stage of breast cancer is 100%.


Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one healthy sweet food for replacing the use of white sugar and artificial sweetener.

In finding natural compounds in cancer therapy, researchers at the United Arab Emirates University conducted an experiment to test the underlying mechanism and molecular targets of manuka honey (MH) on proliferation, invasiveness, and angiogenic potential were investigated using two human breast cancer cell lines, the triple-negative MDA-MB-231 cells and estrogen receptor-positive MCF-7 cells, and the non-neoplastic breast epithelial MCF-10A cell line.


Infection of MH at concentrations of 0.3-1.25% (w/v) induced a dose-dependent inhibition of the proliferation of MDA-MB-231 and MCF-7, but not MCF-10A, cells.

At higher concentrations (>2.5%), MH was found to be generally deleterious to the growth of all three cell lines.

MH induced apoptosis of MDA-MB-231 cells through activation of proteins associated with the cell death programming and cancer cell apoptosis correlated with a loss of proteins associated with cancer cell proliferation.


Furthermore, low concentrations of MH (0.03-1.25% w/v) induced a rapid reduction in tyrosine-phosphorylated STAT3 (pY-STAT3) involved in cell growth and division in MDA-MB-231 and MCF-7 cells.

The maximum inhibition of pY-STAT3 was observed at 1 h with a loss of >80% and coincided with decreased interleukin-6 (IL-6) production.


These results suggested manuka honey (MH) inhibits breast cancer cell lines through many different mechanisms

A total of 50 nulliparous female Sprague-Dawley rats were grouped as follows: Group 0 (healthy normal rats control), Group 1 (negative control; untreated rats), Groups 2, 3, and 4 received daily doses of 0.2, 1.0, and 2.0 g/kg body weight of TH, respectively. The rats in groups 1, 2, 3, and 4 were induced with 80 mg/kg of 1-methyl-1-nitrosourea (MNU) to examine the effects of Tualang honey (TH) against breast cancer.

The TH-treated rats showed a reduction in tumor progression (mean 75.3 days versus 51.5 days) compared to the control.

The incidence (mean 76.6% versus 100%); the multiplicity (mean 2.5 versus 4 tumor masses per rat); the size of tumor mass (mean 0.41 cm versus 1.47 cm [p < 0.05]) and the weight of the tumor mass (mean 1.22 g versus 3.23 g; [p < 0.05]) also lower in the TH treated rats compared to control.

The grade of breast cancer is lower (I and II) compared to control (Grade III),

The efficacy of TH treatment in reducing the expression of breast cancer was attributed to the lower anti-apoptotic proteins (E2, ESR1, and Bcl-xL) expression and a higher pro-apoptotic proteins (Apaf-1 and Caspase-9) expression at serum and on the cancer tissue level.


The breast cancer size breast in the TH-treated groups was smaller mean tumor size (≤ 2 cm3) compared to Controls (≤ 8 cm3). The number of cancers developing in TH-treated groups was also significantly lower.

More importantly, an increasing trend of the apoptotic index (AI) was found in TH-treated groups with an increasing dosage of Tualang Honey compared to the control.

Taken together, adding a portion of honey into a women's diet may have a potential effect in reducing the risk of breast cancer.


And honey may be considered an adjunct therapy combined with the primary medicine for the treatment of breast cancer.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) The IL-6/STAT3 Signaling Pathway Is an Early Target of Manuka Honey-Induced Suppression of Human Breast Cancer Cells by Aryappalli P1, Al-Qubaisi SS1, Attoub S2, George JA1,3, Arafat K2, Ramadi KB1, Mohamed YA1, Al-Dhaheri MM1, Al-Sbiei A1, Fernandez-Cabezudo MJ3, Al-Ramadi BK. (PubMed)
(2) The anti-cancer effects of Tualang honey in modulating breast carcinogenesis: an experimental animal study by Ahmed S1,2, Othman NH. (PubMed)
(3) Inhibitory effects of Tualang Honey on experimental breast cancer in rats: a preliminary study by Kadir EA1, Sulaiman SA, Yahya NK, Othman NH. (PubMed)
(4) Breast cancer risk factors and age at diagnosis: an Icelandic cohort study by Tryggvadóttir L1, Tulinius H, Eyfjord JE, Sigurvinsson T. (PubMed)